* Aij.yj. eft ? . ENCYCLOPAEDIA LONDINENSIS V,' v OR, UNIVERSAL DICTIONARY OF ARTS, SCIENCES, AND LITERATURE: COMPREHENDING, UNDER ONE GENERAL ALPHABETICAL ARRANGEMENT , ALL THE WORDS AND SUBSTANCE OF EVERY KIND OF DICTIONARY EXTANT IN THE ENGLISH LANGUAGE. IN WHICH THE IMPROVED DEPARTMENTS OF THE MECHANICAL ARTS, THE LIBERAL SCIENCES, THE HIGHER MATHEMATICS, AND THE SEVERAL BRANCHES OF POLITE LITERATURE, ARE SELECTED FROM THE ACTS, MEMOIRS, AND TRANSACTIONS, OF THE MOST EMINENT LITERARY SOCIETIES IN EUROPE, ASIA, AND AMERICA. FORMING A COMPREHENSIVE VIEW OF THE RISE, PROGRESS, AND PRESENT STATE, OF HUMAN LEARNING IN EVERY PART OF THE WORLD. EMBELLISHED WITH A MOST MAGNIFICENT SET OF COPPER-PLATE ENGRAVINGS, ILLUSTRATING, AMONGST OTHER INTERESTING SUBJECTS, THE MOST CURIOUS, RARE, AND ELEGANT, PRODUCTIONS OF NATURE, IN EVERY PART OF THE UNIVERSE; AND ENRICHED WITH PORTRAITS OF EMINENT AND LEARNED PERSONAGES, IN ALL AGES OF THE WORLD, COMPILED, DIGESTED, AND ARRANGED, By JOHN WILKES, of MILLAND HOUSE, in the COUNTY of SUSSEX, Esquire; ASSISTED BY EMINENT SCHOLARS OF THE ENGLISH, SCOTCH, AND IRISH, UNIVERSITIES. VOLUME XIX. CONTAINING O-- A comprehenlive Treatife on PATHOLOGY ; And a Hiftory of PERSIA and PERU to the present Time. Eontfon : PRINTED FOR THE PROPRIETOR, AT THE ENCYCLOPEDIA OFFICE, 17, AVE-MARIA-LANE, ST. PAUL’S; AND SOLD BY ALL The BOOKSELLERS. J. and C. ADLARD, Printers 33, Bartholomew Close. 1823. • «\ DESCRIPTION OF THE FRONTISPIECE ILLUSTRATING PATHOLOGY. APOTHEOSIS OF HIPPOCRATES. SEATED IN AN ANTIQUE CAR, DRAWN TOWARDS THE TEMPLE OF IMMORTALITY BY CHIRON AND ANOTHER CENTAUR EQUALLY VERSED IN THE ART OF HEALING,— HIPPOCRATES HOLDS IN HIS RIGHT HAND THE PATERA OF HEALTH, AND IN HIS LEFT THE STAFF AND SERPENT OF jESCULAPIUS, WHOSE DAUGHTER HYGEIA IS REPRESENTED ABOVE,— STREWING MEDICINAL FLOWERS ON THE HEAD OF THE FIRST PATHOLOGIST IN THE WORLD ; WHILST APOLLO, SHOOTING FROM THE CLOUDS 4T THE SERPENT PYTHON, AN EMBLEM OF PESTILENCE, SETS FREE FROM THE CAVERN OF THE MONSTER THE VICTIMS OF DISEASE. DEATH AND THE DEMONS OF LINGERING ANGUISH AND EXCRUCIATING PAIN ARE SEEN FLYING OFF; AND NAUSEATING SICKNESS IS EXEMPLIFIED BY AN EMACIATED FIGURE ON THE FOREGROUND ENCYCLOPAEDIA LONDINENSIS OR, AN UNIVERSAL DICTIONARY OF ARTS, SCIENCES, and LITERATURE. PATHOLOGY. PATHOL'OGY, f [from the Gr. waOo?, fufFering, and Aoyos, a difcourfe.] The fcience or doitrine of difeafes. — 'This tree may naturally be conceived to have been under fome difeafe indifpofing it to fuch fruftifi- cation. And this, in the pathology of plants, may be the difeafe of fuperfoliation mentioned by Theophraftus. Sir T. Browne’s M if cell.- — That part of medicine which relates to diftempers, with their differences, caufes, and effects incident to the human body. As Physiology teaches the nature of the fundtions of the living body in a Hate of health; fo Pathology relates to the various derangements of thefe fundtions which conftitute difeafe. Its objedts, therefore, are to afcertain the various fymptoms which charadterife the different diforders of each organ of the body, and efpe- cially the diagnojlic and pathognomonic fymptoms, which afford the means of difcrimination between difeafes that referable each other; to determine the caufes, both pre- difpofing and exciting, by which difeafes are induced ; to point out the prognojis, or the tendency and probable event of each difeafe, from the changes and combination of the fymptoms ; and daftly, to teach the indications of cure, and the nature and operation of the remedies adapted to the various circumftances and periods of difeafe. The ftudy of pathology prefuppofes an intimate ac¬ quaintance with anatomy and phyf.ology ; or, in other words, with the ftruiture, laws, and operations, of the animal body in a ftate of health. An obfervance of the figns or fymptoms which denote a deviation from this ftate, conftitutes the firft branch of medicine, or J'ympto- matology : an acquaintance with the ufual concatenations obferved by thofe figns, diagnofis. Nqfology regards the arrangement of thefe figns or fymptoms; and atiology ap¬ plies to the cognizance of their caufes, whether external or internal. The application of the properties of inani¬ mate matter to the removal of thefe caufes, or figns, is denominated therapeutics. The fubftances ufed for this latter purpofe are termed materia medica. Before entering into any further examination of thefe fubjeits, it will be neceffary to give a fiiort Iketch of the hiftory of this art; in the courfe of which it will be feen, that its profeffors have been employed for the moft part in endeavouring to explain the phenomena of difeafe and the operation of remedies according to the principles of fome favourite or faftiionable ftudy. Thus mechanics, che- miftry, and metaphyfics, have each in their turn formed the bafis of celebrated medical theories : theories long fince exploded, but of which the recollection may ferve as beacons to warn us from the like errors. It is not, however, for this purpofe only that the writings of the ancients merit our regard. The perufal of them en¬ larges the field of our experience : we often find in them, Vol. XIX, No. 1283, remarks which ferve to explain anomalies in difeafe, and defcriptions which their beautiful and forcible language renders more interefting, and imprints more firmly on our minds. They likewife furnifti hints for the further profecution of inquiry, by fliowing the various lights in which the fame circumftances have been viewed by diffe¬ rent men ; and the long chain of fads they difplay to our view enables us in fome meafure to appreciate the effeds of climate, diet, and even manners, on theconfti- tution of our fpecies. It may be remarked moreover, that fcarcely any fyftem of medicine has been framed, however abfurd, which has not contributed, by the fpirit of inveftigation it excited, and by the new flock of fads its eftabliftiment neceffarily developed, to advance the pro- grefs of the art. RISE and PROGRESS of MEDICINE. The origin of the medical art is involved in great ob- fcurity : yet, its antiquity is undoubtedly great, fince, from its intimate relation with the life of man, the difco- very of it muft have been coeval with that of the moft fimple mechanical arts. The little we know of the earlieft hiftory of our race, leads to the fuppofition, thatfurgery was the firft branch of medicine cultivated. While mankind fubfifted prin¬ cipally by hunting or filhing, they muft, of neceffity, have been fubjeded to a variety of accidents ; fradures, luxations, &c. muft have been frequent among them, and to cure or alleviate thofe obvious maladies muft have been their firft care. It is impoflible to conjedure what means were purfued for the attainment of this end, yet, it is natural to fuppofe, they w'ere, fora long period, very in¬ efficient, and that the knowledge acquired in this ftate of fociety was very confined. It is probable, however, that anatomy was not wholly negleded in this barbarous age. The frequent daughter of wild beafts, and the various purpofes of food, raiment, &c. to which their different parts were appropriated, muft have led to a curfory ac¬ quaintance with the ftrudure of thofe animals ; and thus laid the foundation of comparative anatomy, an acquifi- tion by no means ufelefs in chirurgical operations. En¬ gaged, too, in perpetual hoftility, thefavage probably re¬ garded the examination of human bodies with little or none of that horror which has proved fo inimical to the ftudy of anatomy in more civilized times ; and indeed, (if we may judge from the accounts handed to us by the ancients,) he feems to have felt a brutal pleafure in man¬ gling and deforming the perfons of his deceafed enemies. Thus Homer relates of the Greeks over the body of Heitor, that, OvJ’ ago. oi ti; aiwrw ys tcciq soto. It was in times when more refined habits of life ob¬ tained, and in fituations where gentler purfuits occupied B the Vs a 2 PATHOLOGY. the attention of mankind, that the application of reme¬ dies to the cure of internal maladies took its rife. The tending of flocks and herds, which then became a very general employment, mull have induced habits of leifure and contemplation extremely favourable to theacquifition of experimental knowledge : we may fuppofe that the paf- tors obferved the effects of certain plants on their flocks ; and by a natural and eafy tranfition were induced to admi- nifter the fame fubftances in ailments of their own bodies : a fuppolition which the faffs related by Herodotus and others feem to confirm. The above-mentioned author obferves, that Melampus difcovered the melampodium, or black hellebore, to be poffeffed of a purgative property from having obferved its effect on goats which had broufed in paftures where this herb was indigenous and frequent. Again, we are informed, that the firft ufe of enemas was taught mankind by the Ibis, a bird which is reported to have the power of introducing its bill into the anus, and injefting thereby a quantity of water up the inteftines. Pliny likewife mentions a circumftance to which he attributed the introduflion of phlebotomy; viz. that the Hippopotamus has a cuftom, whenever it becomes large and unwieldy, of opening a vein in its leg by means of a (harp reed which grows on the banks of the Nile. The accuracy of the two latter relations may be queftioned ; yet probably they had their origin in fads, though tradition and the lapfe of time had altered or ex¬ aggerated them. However this may be, there can be little doubt, but that in this branch of medicine, as in anatomy, the phenomena difplayed in the brute creation furniflied man with ufeful hints, and contributed, in a few inftances, to introduce medical herbs to his notice. The confideration of the more or lefs falubrious qualities of his own food led to the introduction of certain regimen, or fyftem of diet, which in thefe times, with the occafional ufe of a few Ample cathartics, was probably fufficient for the cure of mod internal complaints ; and thefe obferva- tions, naturally communicated from father to fon, from one generation to another, and eftabliflied by long and multiplied experiments, at length laid the bafis of materia medica and therapeutics. This empirical pradice, how¬ ever, being often found to fail in affording the expeded relief, a minute attention was paid to the concomitant circutnftances under which previous cures had been ef- feded, and they were imitated accordingly. Thus one plant was direded to be gathered in the night, another when the moon was on the wane, See. accompanied with abfurd and fuperflitious incantations. With refped to the modus operandi of thefe remedies, their firft employers mud have been totally uninformed, in confequence of their ignorance of natural philofophy ; to divine agency therefore they referred the effeds of medicinal herbs, rather than to any innate virtue in the fubftances themfelves. To this agency likewife they af- cribed the occurrence of difeafe, or the reftoration of health ; an idea which appears in feme meafure conneded with that branch of heathen mythology which attributed to every member of the body its guardian genius. Up to this period every man was more or lefs a phy- fleian, and contributed his individual flock of experience to the general good ; but, when the increafing wants and number of the human race compelled them to adopt the forms of political government, and they eftabliflied the military ruler or chieftain on the one hand, and the prieft, druid, or brahmin, on the other, the pradice of medicine fell exclufively into the hands of thofe who executed the facerdotal fundion. They feized with avidity the exer- cile of an art, the unknown or uncertain origin of which favoured the illufion that it was derived immediately from the gods : an art which, clothed in fuperftition, and ve¬ nerable from its antiquity, lent them increafed influence over the vulgar, and was indeed hardly lefs ufeful for that purpofe than the facred or legiflatorial offices which they likewife affumed. They taught that peftilence or difeafe was inflided by the angel of the enraged gods, and eafily found means to perfuade the futferers that fuch dire vifitations were only to be removed through the me¬ dium of prieftly interceffion, joined with lacrifices and offerings. From that paffage in Genefis in which it is faid, that “ Jofeph commanded his fervunts the phyficians to em¬ balm his father,” (Gen. 1. 2.) the writer of the article Medicine in the Encyclopaedia Britannica concludes that the firft phyficians of the Egyptians were not priefts; becaufe, in that age, the Egyptian priefts were in fuch high favour, that they retained their liberty, when, through a public calamity, all the reft of the people were made flaves to the prince. This, however, we do not think a valid objedion; for we cannot doubt that every rank of perfons, priefts as well as others, might, under an abfolute monarchy, be very properly ftyled fervants of the prince, and alfo of his prime minifter. The fame writer feems more founded in his conjedure that the phyficians of the Jews were originally diftind from their priefts ; for we read that, when king Afa was difeafed in his feet, “ he fought not to the Lord, but to the phyficians.” (2Chron.xvi. 12.) Now, feekingtothe priefts, had they been the phyficians, would have been the fame thing as feeking to the Lord; and hence it is fuppofed, that among the Jews the medical art was looked upon as a mere human invention ; and it was thought that the Deity never cured difeafes by making people acquainted with the virtues of this or that herb, but only by his miraculous power. That the fame opi¬ nion prevailed among the nations who were neighbours to the Jews, is alfo probable from what we read of Aha- ziah king of Judah, who, having fent meffengers to in¬ quire of Baalzebub, god of Ekron, concerning his dif¬ eafe, did not defire any remedy from him or his priefts, but limply to know whether he ffiould recover or not. (2 Kings i. 2.) We ffiall now quote a few verfes from a book of Scrip¬ ture (Apocrypha), written “ in the latter times, after the people had been led away captive, and called home again, and almoft after all the prophets.” In this book phy¬ ficians are fpoken of with a much greater degree of re- fpeft, but not as if they were priefts. “My foil, in thy ficknefs be not negligent : but pray unto the Lord, and he will make thee whole. Leave oft" from fin, and order thine hands aright, and cleanfe thy heart from all wick- ednefs. Give a fweet favour, and a memorial of fine flour; and make a fat offering. Then give place to the phyfician, for the Lord hath created him : let him not go from thee, for thou haft need of him. There is a time when in their hands there is good fuccefs. For they fhall alfo pray unto the Lord, that he would profper that which they give for eafe and remedy to prolong life. He that finneth before his Maker, let him fall into the hand of the phyjician. Ecclefiafticus xxxviii. 15. “ What feems moft probable on this fubjeft therefore is, that religion and medicine came to be mixed together only in confequence of that degeneracy into ignorance and fuperftition which took place among all nations. The Egyptians, we know, came at laft to be funk in the moft ridiculous and abfurd fuperftition ; and then, indeed, it is not wonderful that we fliould find theirpriefts com¬ mencing phyficians, and mingling charms, incantations, &c. with their remedies. That this was the cafe, long after the days of Jofeph, we are very certain ; and in¬ deed it feems as natural for ignorance and barbarifm to combine religion with phyfic, as it is for a civilized and enlightened people to keep them feparate. Hence we fee, that among all modern barbarians their priefts or conju¬ rors are their only phyficians.” Ency. Brit. vol. xiii. However this may be, the union of medicineand religion continued for many centuries; but, whatever difeoveries may have been made, the myftery attendant on moft fa¬ cred inflitutions has prevented communication of them to pofterity. Neverthelefs this union was not perhaps fo prejudical to the interefts of fcience as many have fup¬ pofed. 3 PATHOL O G Y. pofed. Conftant facrifice and the frequent habit of in- fpeftingthe “ /pirantwexta” of tire victims, matt have ma¬ terially advanced the progrefs of comparative anatomy ; and the written records firlh adopted by the priefts at lead prevented eftablilhed faffs from falling into oblivion, even if further experience in the cure of difeafe was but (lowly attained. The Egyptians afcribed the invention of medicine to Thoth, ( the Hermes Trifmegiftus of the Greeks,) to whom divine honours were paid ; and they reported that he was the founder of all ufeful knowledge. But there is fome confufion in this account 5 for, on fome occafions, this difcovery was attributed to Ifis or Ofiris, while at other times Apis and Serapis laid claim to the merit of it. It Ihould be recollected, however, that thefe deities werenot like Thoth, mortals who had divine honours paid to them after their deceafe, but embodied or perfonified agents, by means of which the philofophers of the time en¬ deavoured to explain all the laws and operations of matter. They were not likely therefore to be commemorated as the inventors of medicine, although they were undoubt¬ edly invoked as prefiding over health. Athotis, one of the Egyptian kings, left writings on anatomy, a fcience in which the nation could hardly have been deficient, on account of the frequent opportunities they enjoyed of acquiring it while engaged in embalming the bodies of the dead. But the other branches of medicine remained a long time ftationary, fettered by abfurd regulations. In the firft place, the chief-priefts confined themfelves entirely to the exercife of magic rites and prophefies, which they confidered the higher branch of the art, and left the exhibition of remedies to th epajiophori, or image- bearers. Secondly, the priefts of every denomination ■were compelled to follow implicitly the medical precepts of the facred records contained in the fixhermetical books ; for, if they deviated from thefe eftablilhed rules, or intro¬ duced new modes of pra&ice, their temerity was punifhed with death, whether their meafures were fuccefsful or not; thus precluding all idea of improvement. We know very little of the details of their pradtice, as they concealed them with myftic ceremonies ; but that they did not interfere much with the operations of nature may be inferred from a circumftance mentioned by Ariftotle, viz. that they did not adopt adfive treatment till after the fourth day of the difeafe. They had, however, a com- prehenfive fyftem of diet ; for they excluded filh,pork, and fuch other aliments as they confidered injurious to health. They were alfo acquainted with a few valuable remedies, among which may be enumerated fquills, which they ad- miniftered to dropfical patients, and iron, which they ufed as a tonic in cachedlic difeafes ; but they were la¬ mentably deficient in furgery, fince they were unable to cure a common luxation of the foot, which Darius the foil of Hyftafpes met with in hunting. We pafs briefly over the hiftory of this fcience among the Jews, becaufe we find little recorded on the fubjedt except miraculous cures, which cannot properly be faid to apply to natural medicine. Indeed the Jews feem to have been wholly ignorant of the art of phyfic until their in¬ troduction into Egypt, when they found its principles eftablilhed. The alleviation of human infirmity, as recorded in Scrip¬ ture, forms a fubjedl rather to exercife the faith of the theologian than to engage the attention of the patho- logift. It is true, Mofes has arranged a code of medi¬ cinal and dietetic maxims, and has defcribed feveral va¬ rieties of leprofy with the minutenefs of a practical phy- fician ; but it does not appear that he attributed much to the virtue of medicines in thofe complaints. Indeed the adminiftration of remedies could hardly feem necef- fary to a people who were informed by a direCt revelation from the Lord, that, if they would diligently hearken unto his voice, and do that which was right in his fight, he would put none of thofe difeafes on them with which he had afflidfed the Egyptians. To the tribe of Levi was appropriated the adminiftration of the facred remedies. Solomon was celebrated for his knowledge of plants and animals ; and he compofed a treatife on the cure of dif¬ eafes which was deltroyed by Ezekias, left it fliould caufe the facred remedies, rendered more efficacious by the fa- crifices of the priefts, to fall into difufe. Ifaiah the pro¬ phet was likewife famed for medical knowledge : he re- itored Ezekias to life by applying to his wounds cata- plafms of figs. Soon after this period the Jews were dif- perfed in Media and Aflyria, and fubmitted to the yoke of Babylon. It is fuppofed that medicine was cultivated at a very early period among the Hindoos. Of this there can be little doubt. Whether this people were originally de¬ rived from the Egyptians, or the Egyptians from them, the fimilitude in arts, manners, and religion, clearly in¬ dicates that the one nation arofe from the other. Ac¬ cordingly we find the art (food in former times nearly on the fame footing in Hindooftan as it (food in Egypt. The brahmins held the two offices of priefts and phyficians; and, as among the Egyptians, allotted a few difeafes only to the notice of each individual among themfelves. In China, the progrefs of this art feems to have fol¬ lowed a retrograde courfe. For this we are at a lofs to account : certain it is, however, that the authority of the Chinefe'on medical fubjeCts was formerly held in much greater eftimation than it isatprefent. Thejefuits have informed us, that the kings of China paid particular at¬ tention to the encouragement of medicine ; and that Eu¬ ropeans were wont to put greater confidence in the phy¬ ficians of this country than in thofe of any other. More¬ over this fcience was taught in their public fchools, in conjunction with aftronomy. Thefe fchools no longer exift : the Chinefe phyficians implicitly follow the direc¬ tions of the medical code of Hoang-Ti, written, as they aflert, 4000 years ago; and their knowledge is fo fmall and inaccurate, that the emperor Cam-hi commanded Parenhi totranflate the anatomical treatife of Dionis in¬ to the Tartarian language. In Greece, medicine was profecuted with greater ar¬ dour, and its collateral fcience anatomy was inveftigated more fully, than had been the cafe in any country before. The Greeks, like the Egyptians, afcribed the introduc¬ tion of this art to divine revelation: their Apollo and Minerva anfwered to the Ifis and Ofiris of the latter nation ; and Orpheus, the prieft, poet, and phyfician, ufurped the place of Thoth ; and the fable of his bringing his wife Eurydice from Hell probably applies to his fkill in difeafes. But the priority has been given by fome to Me- lampus, who was a phyfician of great celebrity at Pylos. He cured the daughters of Praetos king of Argos, who were afflidfed with leprofy and madnefs ; and he removed like¬ wife the impotence of Iphiclus, by which cure he alfo faved his own life. The next on record i3 the centaur Chiron, who was preceptor to moll of the warriors and great men of his age, but with the greateft fuccefs to Aifculapius, or Afclepias, a king of Theffaly (and reputed fon of Apollo), who made fo great proficiency, that the fable fays Jupiter was obliged to remove him from the earth to preferve his brother Pluto’s kingdom from depopulation. His fons, Podalirius and Machaon, received from their father the art of healing, which they exereifed with fuccefs at the fiege of Troy, and tranfmitted to their defcendants the Afclepiades. At firft, the Afclepiades promulgated their doCtrines as priefts in the temples of the god of health; but, as fchifms arofe among the different fe&s, each tem¬ ple became in time a diftinCt medical fchool. Thus the fchool of Ceredos and Cos were founded, in which for fome time the defcendants of Asfculapius alone were per¬ mitted to pra&ife : but it was afterwards judged necef- fary to admit a limited number of pupils from other fa¬ milies, who bound themfelves by oath to obferve the rules 4 PATHOLOGY. rules of the Afclepiades. From the fchool of Cos arofe Hippocrates, the fourteenth in defcent from Aifculapius. But the ftudy of medicine was not confined to this fa¬ mily ; it formed part of the education of kings and heroes. Hercules received from Chiron, in earlier times, the ru¬ diments of medicine. Ariftasus, king of Arcadia, was likewife a fcholar of the centaurs : to him we owe the in¬ troduction of the herb Jylphium, fuppofed by fome to be aflafcetida. Jafon, Telamon, Thefeus and Peleus,Ulyfles, Diomed, Hippolytus, and Achilles, were proficients in this art. Achilles is faid indeed to have firft ufed verdi¬ gris for the purpofe of cleaning foul ulcers. But all of them were inferior to the accomplilhed, the injured, Pa- lamedes ; by the excellent rules of diet and exercife to which he fubmitted the foldiers, he prevented the plague from entering the Grecian camp after it had carried its ravages over raoft of the cities of the Hellefpont and even Troy itfelf. ./Efculapiusflouriftied about 50 years before the Trojan war 5 and we have feen that his two Tons diftinguilhed themfelves in that war both by their valour and by their ikill in curing wounds. This indeed is the whole of the medical Ikill attributed to them by Homer ; for, in the plague which broke out in the Grecian camp, l.edoes not mention their being at all confulted. Nay, what is (fill more ftrange, though he fometimes mentions his heroes having their bones broken, he never takes notice of their being reduced or cured by any other than fupernatural means; as in the cafe of ^Eneas, whofe thigh-bone was broken by a Hone call at him by Diomed. The methods which thefe two famous furgeons ufed in curing the wounds of their fellow-foldiers, feems to have been the extracting or cutting out the darts which inflicted them, and applying emollient fomentations orftyptics to them when neceflary : and to thefe they undoubtedly attributed much more virtue than they could poflibly poflefs ; as appears from the following lines, where Homer defcribes Eurypylus as wounded and under the hands of Patroclus, who would certainly praCtife according to the directions of the furgeons of that time : Patroclus cut the forky fteel away ; Then in his hand a bitter root he bruis’d, The wound he walh’d, the llyptic juice infus’d. The clofing flefli that injtant ceas’d to glow; The wound to torture, and the blood to flow. Iliad, xi. The philofophers of Greece, by adapting their fpecula- tions to the elucidation of this fcience, lent it material aid. Pythagoras vifited Egypt and India, collected the therapeutic and dietetic maxims of thofe nations, and in¬ troduced them into his own country: unfortunately, in fo doing, he forgot the difference of climate and habits, .and endeavoured to apply the vegetable regimen too ftriCtly. He attended diligently to the ltudy of the ani¬ mal economy ; and he founded the fchool of Crotona, whence arofe Alcmaeon, an anatomift of great repute. With refpeCt to the knowledge this latter perfonage pof- fefled of the human ftruCture, it admits of doubt ; but his /kill in comparative anatomy is well attefted by Ariftotle, Diogenes, and Plutarch: with him too originated the firft theory of fleep : he fuppofed, that, when the blood flows in the larger veflels only, fleep is induced; but, when it returns in the finaller ones, waking occurs. Empedocles, the diftinguiflied philofopher, was another ornament of the Pythagorean feCt. Befides thefe philofophers, and the Afclepiades, there were, at this period, other perfons who devoted them¬ felves to the profeflion of phyfic, and who occafionally were remunerated by a fixed falary. Thus Democetes of Crotona was retained at the court of the Samian tyrant Polycrates, with an allowance of two talents yearly : being afterwards taken prifoner, and carried as a flave in- do Perfia, he acquired great repute by curing Darius of a •fprained foot, after the Egyptian phyficians had failed ; iand alfo by his fuccefsful treatment of a tumour of the breaft, under which Atofia, the daughter of Cyrus, and wife of Darius, had laboured for a confiaerable time. (Herodot. iii. 133.) Such pradlitioners, from their wan¬ dering lives, were fometimes defignated by the name of s-Egio&vrat. Of this clafs, one of. the moll confpicuous was Acron of Agrigentum, the contemporary and rival of Empedocles, refpedting whom Pliny has fallen into a ftrange error, in defcribing him as the founder of the empiric fedt “under the fandtion of Empedocles.” Ac¬ cording to Diogenes, he was the author of fome books on medicine and dietetics, written in the Doric dialed! ; and he fignalized himfelf at Athens, in the time of the great plague, by introducing the pradtice of fumigations, and thus affording relief to many. (Plut. de Ifld. et Ofir.) The gymnafia of ancient Greece feem alfo to have con¬ tributed to the improvement of the art. It belonged to the gymnafiarch, or pulajlrophylux , to regulate the diet of the youths who were trained in thefe feminaries ;_the yt //Avaran were prefumed to be converfant with difeafes; and it was the bufinefs of the ctXtiiflai to perform venefec- tion, to drefs wounds, fradtures, &c. They were fome¬ times called phyficians. It was in thefe feminaries that the gymnaftic fyftem of medicine originated, under the au- fpices of Iccus of Tarentum, and Herodicus of Selymbria. About this time, and contemporary with Hippocrates, flourilhed Democritus of Abdera, who made the firft public difledtion on record: he applied himfelf to this talk for the purpofe of afcertaining the nature and courfe of the bile; and difledted with fo much afliduity, that the Abderites fufpedted him of infanity, and accordingly fent for Hippocrates (as it is reported) to cure him : but the latter, fo far from finding him mad, difcovered that he was extremely wife, as he exprefles himfelf in a letter to his friend Damagetus. As we are now arrived at an era in which the hiftory of pathology will afl’ume, as it were, a tangible fliape, we fliall divide our large field of information into three fec- tions ; the firft reaching to the decline of the art during the dark ages ; the fecond from that time to the end of the fixteenth century; and the third, to the prefent time. I. From the Time of Hippocrates to the dark Ages. Hippocrates has juftly been ftyled the Father of Me¬ dicine, fince his writings are the moft ancient exprefsly on this fubjedt which have been preferved. His tran- fcendent merit alone would, however, fecure to him that title. He has left behind him uleful hints on almoft every branch of medicine; and has inveftigated fome of them with an exadtnefs which has left us little to defire. On anatomy, though probably he did. not himfelf make dif- fedtions, he has compiled all the information extant in his time ; and his theory of medicine, though long fince exploded, merits, in comparifon with the hypothetical and extravagant notions that had preceded it, much en¬ comium. It was certainly more comprehenfible, and more explanatory of known fadts, than the dodtrine of Pythagoras, which accounted for every thing by the fcience of numbers ; or than that of Empedocles, which referred all phenomena to the agency of an ethereal fpi- rit. It is, however, the practical part of medicine that Hippocrates has fo much elucidated. We difcard his theory of Nature, his concodtions* and infpiflations ; but in his account of difeafes, in the accurate hiftories he has afforded us of figns or fymptoms, their relations and ef- fedts, he Hands unrivalled. His prognojlics, too, have comparatively been little improved in the prefent day : indeed he carried them to fo great a degree of perfedtion, that he and his pupils were regarded by the vulgar as prophets. It ftiould be likewife recorded of him, that he endeavoured to dived the art he profefled of all that myl- teryand fuperftition in which he found it enveloped, and that he gave the firft outline of a fubjedt of great impor¬ tance, medical ethics. His authority has been revered for ages, and his maxims have been received as dogmas, not only in the fchools, but in the courts of law. We need 1 not PATHOLOGY. not therefore be furprifed that many men of inferior ce¬ lebrity fhould have endeavoured to render their works popular by afcribing them to this famous phyfician. Ac¬ cordingly we find many writings extant bearing his name, which are evidently fpurious. It fhould be remarked however, that thefe writings are nearly of the fame date as his genuine cOmpofitions, and contain the prevalent doftrines of his time. The pathology of Hippocrates was founded on the af- fumption, that a principle exifis in the animal, tending to the prefervation of health, and the- removal of difeafe. To this principle, which he denominates Nature, heap- pears to have attributed fome degree of intelligence, and even in one place applies to it the epithet of juji. “ The manner in which Nature adts, or commands her fubfer- vient power to adt, is by attracting what is good and agreeable to each fpecies, and by retaining, preparing, and changing, it ; and on the other fide in rejedting what¬ ever is fuperfluous or hurtful, after fhe has feparated it from the good.” This is the foundation of the dodtrine of depuration, concoction, and criiis, in fevers, fo much infilled upon by Hippocrates and many other phyficians. He fuppofes alfo, that every thing has an inclination to be joined to what agrees with it, and to remove from every thing contrary to it ; and like wife that there is an affinity between the feveral parts of the body, by which they mutually fympathife with each other. Hippocrates referred the production of mod difeafes to diet and air ; to the former of which he attached fo much importance, that he compofed feveral books concerning it : yet in another part of his works he gives the judicious maxim, that while in health we fhould by no means at¬ tach ourfelves to nice and delicate habits of living, or live with too much regularity; becaufe thofe who have once begun to live by rule, become difordered if they depart in the lead from it. In the choice of fituation with regard to the purity of air, he was particularly care¬ ful ; and noted efpecially the winds, the times of the fol- dices and equinoxes, & c. He likewife took into con- lideration the effects produced by deep, watching, exer- cife, &c. and attached great importance to certain hu¬ mours, particularly blood and bile. His claffification of difeafes was arranged according to the circumdances of their danger, duration, or locality : thus fome difeafes were mortal, dangerous, or curable; others acute or chronic; and again others were divided into endemical, epidemical, and l'poradic. Hereditary difeafes he likewife noticed. We are obliged to Hippocrates for the remark, that there are certain ftages in every didemper; a point of great practical importance. He generally noticed four; the beginning, the augmentation, the height, and the decline. In mortal difeafes, death took place indead of the decline ; on which account this latter was reckoned by Hippocrates to be worthy of particular in vedigation. He conceived that during this dage a crifis took place ; i. e. that the mortified matter which. produced the difeafe was by fome means feparated from the body ; but this feparation never occurred until the humour was fuffi- ciently concoded ; that is to lay, brought into a fit date for expuifion from the body, by the efforts of Nature. Moreover, this author fuppofed, that, as every fruit has a limited time to ripen in, fo concottion could not be ac- complilbed unlefs within a certain period. He took much pains to edabiilh critical day*, or the times when thefe concoctions and crifes fnculd take place; and he deemed them moll favourable when they occurred on odd days. In noting the ligns and characters of difeafe, Hippo¬ crates was extremely minute, and that chiefly with a view to foretelling the event of the malady. He obferved the altered appearance of every feature of the face, the com¬ plexion ; the dim, fierce, fparkling, or other exprefiion, of the eyes. He paid attention to the poflure and atti¬ tude of the fufferer •. he remarked the debility which ge¬ nerally attends the continued fupine pofition ; and he noticed the picking of the bed-clothes, the uneafy and Vol. XIX. No. 1283. 5 tremulous motions, and likewife the fubfultus tendinum, which denote death in patients affected with fevers. Hippocrates paid particular attention to the refpiration, the different Hates of which affilled him in forming his prognofis. He examined the urine with great care ; but, as his remarks on it chiefly regarded his humoral hypo- thelis, they are now of little intereft. He noticed, how¬ ever, that the crifis of fever was often brought about when the urine became very abundant, and the thick ap¬ pearance of it denoted difeafe of the bladder ; he was in the habit of comparing the appearance of this evacuation with that of the tongue. The faeces too were invelligated, in re¬ lation to their odour, confluence, and colour, by this au¬ thor. But he has recorded more important fails concerning the expectoration which arifes in pulmonary complaints: he fays that, when it is mixed with blood (in chronic cafes), when it is entirely wanting, or when it is fo co¬ pious as to caufe rattling in the throat, it denotes ex¬ treme danger; but that, when it is mixed with puru¬ lent matter, it indicates confumption, and terminates in death. Concerning perfpiration, Hippocrates has re¬ corded the beneficial effects derived from its occurrence in fevers; when it is general, it often produces the crifis : but he has well remarked the danger of cold and partial fweats. It has been doubted whether this celebrated.phyfician underltood any thing about the pulfe. It has been fup¬ pofed that the paffages found in his works apply only to the pulfation which is feit in an inflamed part. But his knowledge mull have extended further than this on the fubjedt; becaufe he talks of flow and tremulous pulfes; and in his Coucce Pranotionrs he remarks, that the feniible pulfation of the artery in the elbow indicates delirium, or the prelenceof violent anger. Exercife was not neglected by Hippocrates; but he jullly blames his preceptor Herodicus for recommending it to thofe afflidled with fevers or inflammatory affedlions. Indeed the latter phyfician was fo fond of gymnaftics, that he made his patients walk from Athens to Megara, a diftance of twenty-five miles, and return as foon as they had touched the walls of the city. Yet Hippocrates juflly appreciated the advantage of exercife in chronic difeafes; and even tells 11s that “ we mull fometimes pufh the timorous out of bed, and roufe up the lazy.” Hippocrates gave many general rules of importance in regard to the ellablilhment of health, among which are the importantones of keeping up, in molt cafes, a regular difcharge; to deplete the plethoric by low living, and to avoid fudden expofure to increafed or diminiffied tempe¬ rature. The therapeutical maxims of Hippocrates were few and Ample, and all founded on his theory of Nature cu¬ ring difeafes ; infomuch that all that could be done was to remove fuch things as were injurious to the agency of that principle, or to affiil it in its operations when it was deficient. He alferted, in the firft place, “That con¬ traries, or oppofltes, are the remedies for each other;” and this maxim he explains by an aphorifm ; in which he fays, that evacuations cure thofe dillempers which come from repletion, and repletion thofe that are caufed by evacuation : fo heat is deflroyed by cold, and cold by heat, & c. In thelecond place, he alferted that phyfic is an ad¬ dition of what is wanting, and a fubtr.idlion or retrench¬ ment of what is fuperfluous : an axiom which is thus ex¬ plained, that there are fome juices or humours, which in particular cafes ought to be evacuated, or driven out of the body, or dried up ; and fome others which ought to be reftored to the body, or caufed to be produced there again. As to the method to be taken for this addition or retrenchment, he gives this general caution, “That you ought to be careful how you fill up, or evacuate, all at once, or too quickly, or too much ; and that it is equally dangerous to heat or cool again on a fudden ; or, rather, you ought not to do it : every thing that runs to an excels being an enemy to nature.” In the fourth place, he allowed that we ought fometimes to C dilate. G PATHOLOGY. dilate, and fometimes to lock up ; to dilate, or open the paftages by which the humours are voided naturally, when they are not fufficiently opened, or when they are clofed ; and, on the contrary, to lock up or ilraiten the paftages that are relaxed, when the juices that pafs there ought not to pafs, or when they pafs in too great quantity. He adds, that we ought fometimes to linooth, and fometimes to make rough ; fometimes to harden, and fometimes to fatten again; fometimes to make more fine or fupple; fometimes to thicken ; fome¬ times to roufe up, and at other times to ftupify or take away the fenfe ; all in relation to the folid parts of the body, or to the humours. He gives alfo this farther lef- fon, That we ought to have regard to thecourfe the hu¬ mours take, from whence they come and whither they go; and in confequence of that, when they go where they ought not, that we make them take a turn-about, or carry them another way, almoft like the turning the courfe of a river; or, upon other occafions, that we en¬ deavour, if poffibie, to recaj, or make the fame humours return back again ; drawing upward fuch as have a ten¬ dency downward, and drawing downward fuch as tend upward. We ought alfo to carry off, by con venient ways, that which is necelfary to be carried off; and not let the humours once evacuated, enter into the veffels again. Hippocrates giVes alfo the following inftruflion ; “ That, when we do any thing according to reafon, though the fuccefs be not anfwerable, we ought not eafily, or too haftily, to alter the manner of afliug, as long as the rea- fons for it are yet good.” But, as this maxim might fometimes prove deceitful, he gives the following as a cor¬ rector to it : “We ought (fays he) to mind with a great deal of attention what gives eafe, and what creates pain ; what is eafily fupported, and what cannot be endured. We ought not to do any thing raflily ; but ought often to paufe, or wait, without doing any thing: by this way, if you do the patient no good, you will at ieaft do him no hurt.” Thefe are the principal and moll general maxims of the pradtice of Hippocrates, and which proceed upon the iuppontion laid down at the beginning, viz. that Nature cures difeafes. We next proceed to confider particularly the remedies employed by him, which will ferve to give us further inftruflions concerning his practice. Diet was the firft, the principal, and often the only, re¬ medy made life of by this great phyfician to anfwer moll of the intentions above mentioned; by means of it he oppofed the moift to dry, hot to cold, See. and what he looked upon to be the mod confiderable point was, that thus he fupported Nature, and affifted her to overcome the malady. The dietetic part of medicine was fo much the invention of Hippocrates himfelf, that he was very de- firous to be accounted the author of it ; and, the better to make it appear that it was a new remedy in his days, lie fays exprefsly, that the ancients had written almoft no¬ thing concerning the diet of the fick, having omitted this point, though it was one of the mod ed'ential parts of the art. There were many difeafes for which he judged the bath was a proper remedy ; and lie takes notice of all the cir- cumdances that are necelfary in order to caufe t lie pa¬ tient to receive benefit from it, among which the follow¬ ing are the principal. The patient that bathes himfelf mud remain dill and quiet in his place, without fpeaking, while the adidants throw water over his head or are wiping him dry; for which lad purpofe he defired them to keep fponges, indead of that indrument called by the ancients Jtrigil, which ferved to rub od’ from the fkin the dirt and nadinefs left upon it by the unguents and oils with which they anointed themfelves. He mud alfo take care not to catch cold; and mud not bathe immediately after eating or drinking, nor eat or drink immediately after coming out of the bath. Regard mud alfo be had whether the patient has been accudomed to bathe while in health, and whether he has been benefited or hurt by it. Ladly, he mud abdain from the bath when the body is too open, or too codive, or when he is too weak ; or if he has an inclination to vomit, a great lofs of appetite, or bleeds at the nofe. When he found that diet, exercife, and bathing, were not fufficient to Vale nature of a burden of corrupted hu¬ mours, he was obliged to make ufe of other means ; of which vomiting, bleeding, and purging, were the chief. Vomits were a favourite remedy with Hippocrates. He preferibed them to people in health, by way of preventa- tives, direfling them to be taken once or twice a-month in the winter and the fpring. The mod fimple of thefe was a decoftion of hyfl'op, with the addition of a littie vinegar and fait. With regard to the fick, he fometimes advifed them to the fame, when his intentions were only to cleanfe the domach. But, when he had a mind to re- cal the humours, as lie termed it, from the in mod recedes of tiie body, he made ufe of brifker remedies. Among thefe was white hellebore; and this indeed he mod fre¬ quently ufed to excite vomiting. He gave this root par¬ ticularly to melancholy and mad people; and from the great ufe made of it in thefe cafes by Hippocrates and other ancient phyficians, the phrafe, to have need of helle¬ bore, became a proverbial exprefiion for being out of one’s fenfes. He gave it alfo in deduxions, which come, accor¬ ding to him, from the brain, and throw themfeives on the nodrils or ears, or fill the mouth with faliva, or that caufe dubborn pains in the head, and a wearinefs or an extra¬ ordinary lieavinefs, or a weaknefs of the knees, or a fwel- ling all over the body. He gave it to confumptive per- ions in broth of lentils, to fuch as were afflicted with the dropfy called leucnphlegmatia, and in other chronical dif- orders. But we do not find that he made ufe of it in acute didempers, except in the cholera morbus, where he fays he preferibed it with benefit. Some took this medi¬ cine fading; but mod took it after fupper, as was com¬ monly praftifed with regard to vomits taken by way of prevention. The reafon why he gave this medicine mod commonly after eating was, that by mixing with the ali¬ ment, its acrimony might be fomewhat abated, and it might operate with lefs violence on the membranes of the domach. In the didemper called empyema (ora colleftion of mat¬ ter in the bread), he made ufe of a very rough medicine. He commanded the patient to draw in his tongue as much as he was able; and, when that was done, he endea¬ voured to put into the hollow of the lungs a liquor that- irritated the part, which, railing a violent cough, forced the lungs to difeharge the purulent matter contained in them. The materials that he ufed for this purpofe were of different forts; fometimes he took the root of arum, which he ordered to be boiled with a little fait in a fuffi- cient quantity of water and oil ; difl'olving a little honey in it. At other times, when he intended to purge more drongly, he took the flowers of copper and hellebore; after that he (hook the patient violently by the fhoulders, the better to loofen the pus. This remedy, according to Galen, he received from the Cnidian phyficians ; and it has never been ufed by fucceeding ones, probably be- caufe the patients could not fuller it. Blood-letting was another method of evacuation pretty much ufed by Hippocrates; and in inflammatory affec¬ tions he praflifed it in a large and decided manner; for he fometimes opened the veins of both arms, and kept them running till the patient fainted. The principal maladies in which he had recourfe to bleeding were in¬ flammations of the liver, fpleen, lungs, or other vifeera ; quinfy, pleurify, and pain in the head; but in fome in- liances of chronic difeafe, as dropfy and jaundice, he likewife performed this operation. In fevers he difap- proved of venefeflion, becaufe he conceived thofe difeafes were produced by certain humours which could not be expelled by that means : it muff, however, be underftood, that he did not extend this rule to fymptomatic fevers, but rather to thofe which were not preceded by figns of local PATHOLOGY. local inflammation. Indeed, in his writings, the term fever is only applied to that clafs which we call idiopathic ; and there feems good reafon to fuppofe, that, in the com¬ mencement of a fever ariling out of vilceral inflammation, he bled very copioufly. He likewife performed cupping ■with fcarificators ; and occafionally ufed the femicupium, which he fuppofed would draw the humours from the affeCted part by means of aUrudiion. As molt of the purgatives in ufe in the time of Hip¬ pocrates were very violent in their operation, often pro¬ ducing ficknefs, he prefcribed them with great caution. He did not give them to pregnant women, old people, or children ; nor during the dog-days. He ufed them more frequently in chronic than acute difeafes, and chiefly with a view to the expulfion of fome particular humour; to each of thel'e humours he applied a leparate kind of pur¬ gative ; hence the diltinCtion of thofe fubftances into hy- d-ragogues, cholagogues, &c. now juflly exploded. Hip¬ pocrates likewife ufed errhines, which he laid relieved pain in the head by drawing the phlegm from the brain; i'udoriflcs and diuretics, which were likewife for the pur- pofe of evacuating fome peccant humour, and narcotics, or, as he called them, hypnotics, to produce fleep. But of thefe laft he was very lparing. To medicines which ex¬ perience had proved to be efficacious, but of which the operation was inexplicable by this humoral pathology, he applied the term Jpecifics. He ufed fomentations, in which different herbs were boiled, either by direCt application or in the form of vapour. Nor did he neglect cataplafms, ointments, cauftics, and collyria ; all of which he pre¬ pared himfelf, or caufed to be made by his fervants un¬ der his own immediate infpeCtion. The pharmaceutical diftinCtions of medicines into mixtures, powders, and pills, were obferved in this time, and likewife fomething analogous to our lozenge was ufed ; it was called a lum- lative, was of a foft confidence, and was retained in the patient’s mouth until flowly diffolved. The practice of Hippocrates was beneficial to himfelf; for it is generally underftood that he reached the age of a hundred years, and died about 360 years before the birth of Chrift. Soon after the death of Hippocrates, the profeffors of medicine became divided into two feCts ; the Dogmatifts and the Empirics. The feed of the Dogmatists was founded by Theffalus and Draco the fons, and Polybus the fon-in-law, of Hip¬ pocrates. Their leading tenets are recorded in the book “On the Nature of Man,” which has falfely been attri¬ buted to Hippocrates. Ariftotle conjedtures that it was written by Polybus. The Dogmatilts were fometimes coiled logici, or logicians, from their ufing the rules of logic and reafon in the fubjedts of their profeflion. They fet out with the rule, that, “when experience fails, rea¬ fon mayfuffice.” Unfortunately, however, they took lit¬ tle pains to confult experience, but were perpetually oc¬ cupied with endeavouring to trace difeafe to its fecret and remote caufes. The fyftem of the Empirics, as the term imports, was founded altogether upon experience-, and thofe who be¬ longed to this fedt have remarked, that there are three modes by which we learn, from experience, to diltinguith what is advantageous and what is prejudicial, in regard to our health. 1. The firlt of thefe, and the molt Ample, arifes from accident. A perfon, for example, having a violent pain in the head,' happens to fall, and divides a veffel in the forehead ; and it is obferved that, having loll blood, his pain is relieved, Under the fame mode, they include the experience which is acquired by obfer- ving the fpontaneous operations of the conftitution, where no remedy has been applied, as in the following cafe : a perfon labouring under a fever, finds his difeafe mitigated, after a hemorrhagy from the nofe, a profufe perfpiration, or a diarrhoea. 2. The fecond mode of gaining experience is, that in which fomething is done by deftgn , with a view to afeertain what will be the fuccels of it; as, for inftance, when a perfon, having been bitten ? by a ferpent, or other venomous creature, applies to the bite the firft herb that he finds ; or when a mart' attempts to alleviate the fymptoms of an acute and burning fever, by drinking as copioufly as he is able of cold water ; or when a perfon tries a remedy, fuggefted tohimby a dream, as was frequently done in heathenilh times. 3. The third mode of experimenting is, that which the empirics termed imitative; W'hicb is purfued in cafes, when, after having remarked the e fleets refulting from accident, or the fpontaneous aCtions of the fyftem, on the one hand, or from dejign on the other, we make an attempt to ac- complilh afimilar refult by imitating that which u!as done on thofe occafions. This laft fort of experience, they contend, is that which peculiarly conftitutes the art of medicine, when it lias been frequently repeated. They call that obj'ervation (r'/5p7j(7K,) or autopfia, (avr ottcicc,) which each individual fees himfelf ; and ufe the term hijlory or record, (i{Topi:t,) for fuch obfervation, when committed to writing; that is, the autopfia , or perfonal experience, confifts of the obfer- vations which each perfon has made, by his attention to the progrefs of a difeafe, whether in regard to its fymp¬ toms and changes, or to the remedies employed ; while the record is a fort of narration or regifter of all that was obferved by thofe individuals ; which regifter being com¬ pleted, (i. e. including all the difeafes incident to man¬ kind, and the remedies adminiftered for their alleviation, ) the art of medicine w'ould be eftabliflied with a confider- able degree of certainty. But, as new difeafes fometimes occur, in regard to which neither our perfonal experience, nor the obfervations of others, can furnilh us with any afliftance; and we meet with diforders in particular fitua- tions, where the means of relief, fanCtioned by experience elfewhere, are not within our reach ; we mull neceffariiy have recourfe to fome other expedient in order to allevi¬ ate the bufferings of the patient. The empirics were pro¬ vided againfl this particular difficulty, in what they termed a J'ubjiitution of fimilar means, ( tranjltus ad fimile , as the Latins have tranflated it.) This was a new experi¬ ment, which they inftituted, after having compared one difeafe with another ; or one part of the body with ano¬ ther, of fimilar ftruCture; or, lartly, one remedy, the na¬ ture of which was afeertained by experiment, with ano¬ ther which refembled it. “ They tried, for example, in herpetic eruptions the remedies which had relieved eryji- pelus ; and, in the difeafes of the arms, they employed the expedients which had been praCtifed in thofe of the /egs ; &c. & c.” Obfervation, then, record, and the j'ubjiitution of fimilar means, were the three fundamental refources of the art of medicine, according to the empirics: and thefe were denominated, by Glaucias and others, “ the tripod of medicine.” There is obvioufly a great deal of good fenfe and found philofophy in this doctrine of empincifm. It points out the true mode of invelfigating the phenomena of nature by unwearied experiment; the mode which Bacon la¬ boured to inculcate, which Newton fuccefsfully purfued, and which has led the philofophers of later times to the development of that fund of natural knowledge in the fciences of electricity, chemiltry, mechanical, and every branch of natural, philolophy, by which modern inquiry is diftinguifhed. Compared with this fpecies of invefti- gation, how futile are the lpeculations, mifnamed philo- lophy in the fchools, relative to elements and ellences, which had no exiftence except in the imagination of the difputants. At firft much rancour and animofity fubfifted between thefe two parties ; but, in procefs of time, their practice was found to coincide in many material points; for, though the dogmatifts were much addicted to hypothefis, they could not fail to make clinical obfervations when en¬ gaged in practice; and the empirics did not entirely con- tine tliemlelves to their profeffed mode of acquiring know¬ ledge, but occafionally indulged in that paflion for the¬ ory and generalization which is fo common in a philofa- phic. 8 PATHOLOGY. phic age. It is evident, then, that both the dogmatic and empiric phyficians appealed to experience, and that nei¬ ther excluded altogether the dictates of reafon and re¬ flexion. The principal difference in their tenets appears to have confided in this : that the empirics real'oned only from the facts afcertained by obfervation, without at¬ tempting to explain their effential and infcrutable nature by hypothefesj and that the latter fpeculated upon the mode and nature of every phenomenon in the animal body, and took thefe fpeculations as the bafis of their reafoning: an error in the inveftigation of nature, which, as we have before faid, was fo well expofed by lord Bacon in modern times; and which was practically illuf- trated in the triumph of Newton’s empirical doXrines, over the dogmatical hypothefes of Des Cartes. The empirical feX had not enjoyed great influence or diffemination till Serapion of Alexandria, in the year be¬ fore Chrift 280, took up and defended their doXrines with great fpirit : hence fome have called him the foun¬ der of the feX. His works are loft; hut what has been tranfmitted of his opinion by other authors, tends to prove that he followed the praXice of Hippocrates with great fidelity, though he feverely criticifed his reafon- ings. It is chiefly to the induftry of the ancient empirics that we are indebted for the introduction, or rather for the full knowledge, of fedative and n'arcotic remedies; on the liberal ufe of which probably depended the l'upe- rior reputation acquired by fome of them over their more cautious antagonifts. Of this fuperiority, a lingular in- ftance occurs in the many exifting teftimonies to the fame of Heraclides of Tarentum. Celfus Aurelianus calls him “Empiricorum Princeps;” and Galen fpeaks of him in very high terms. He fo far deviated from the praCiice of the flriCt empirics, that he fearched after the caufes of difeafe with almoft as much pertinacity as the dogmatifts; by no means however negleCting the practical obferva- tions which were taught in the empirical fchool. This union of theory and praCtice led him to many ufeful refults, more particularly in refpeCt to acute and dangerous difeafes, his treatment of which appears to have been extremely judicious. He feems to have made a more liberal ufe of aCtive medicaments, efpecially of the narcotic clafs, than his predeceflbrs, having been the firft to introduce opium into ufe as a medicine-; and was very induftrious in his inveftigation of animal, vegetable, and mineral, fubftances, with a view to enrich the catalogue of the materia medica. To the books Which he wrote upon this fubjeX, he gave the name of the individuals to whom he dedicated them, according to Galen; entitling one “Aftydamas,” and another “ Antiochis.” He likewife wrote on the fubjeX of diet, and the regimen to he obferved in difeafes, in which abftinence feems to have been pufhed to a great extent. It is eafy to fee, however, that the direXion of medical inquiry, given by the empirical phyficians, to the difeo- Very of the qualities of medicinal fubftances, or drugs, would in all probability lead to many abufes and evils. Experiment of this fort being much eafier, at lealt when careiefsly made, than that unremitting and accurate ob¬ fervation of the phenomena of difeafes which alone can conftitute the fcientific phyfician, the ignorant and idle would content themfelves with pharmaceutic experi¬ ments, and negleCf the talk of pathological inveftigation ; and fejfilh craft and dilhonefty would loon learn toimpofe on the credulity of the people, in the adminiftration of fe£ ret remedies, when the ufe of a particular drug, and not the general treatment of a difeafe, was fuppofed to be the efler.ee of medicine. Hence it actually happened, even in the early ages of phyfic, that thefe ignorant and illiberal pretenders to panaceas, and infallible remedies, who did not know one difeafe from another by its l'ymp- tonis, appeared in Egypt, Greece, and Arabia, and were much complained of by their more rational contempora¬ ries. In all fucceeding ages, the race of thefe illiterate pretenders has been multiplied, under the abufed name of empirics, by which we now underftand thofe perfons who fell or adminifter a particular drug, or compound, as a remedy for a given diforder, without any confidera- tion as to the variations of that diforder, in its different ftages, or degrees of violence, or as it occurs in different conllitutions, climates, or feafons, or in perfons of dif¬ ferent age, fex, ftrength, &c. Such a practice implies a total ignorance of the nature of the human conftitu- tion, both in health and difeafe ; and therefore is ge¬ nerally found to be the refort of the illiterate and felfifli, not to fay difhoneff, part of mankind. After the death of Heraclides, the ftudy of the materia medica took a new direXion, in confequence of the at¬ tention that was paid to the fubjeX of poifons and their antidotes, by the kings of Pergamus and Pontus. The antidote which was invented by the latter is well known, though its efficacy has never been proved. Even Sere- nus, who is in general fufnciently credulous, feems to have had no very high opinion of its virtues : Antidofus vero multis Mithridatica fertur Confociata modis, fed Magnus ferinia regis Cum caperet viXor, viiem deprehendit in illis Synthefin, et vulgata fatis medicamina rifit. Nicander of Colophon, who was the contemporary of Attalus king of Pergamus, acquired great fame as a grammarian, a poet, and a phyfician. He endeavoured with the vvorft fuccefs to clothe medicine in flowing num¬ bers? Kis only pieces extant are the Alexipharmica and Theriaca, which contain obfervations concerning poifon and their antidotes, which (as we have faid) became a very favourite purfuit about his time. See Nicander, vol. xvii. p. 45. ■ At the time that the fons of Hippocrates founded the dogmatic feX ; Eudoxus of Cnidos framed a lylleni of medicine founded on the philofophy of Pythagoras, and the praXice of the Egyptians. It was therefore princi¬ pally direXed to the dietetic part of medicine. He was followed by his pupil Chryfippus, of wliofe praifice we have nothing memorable to relate, but that he regarded cabbage as a very important remedy, and was very averfe to the operation of bleeding or the exhibition of purga¬ tives. He was the preceptor of the renowned Erafiftratus. Diocles of Caryflus was about this period a praXitioner of repute ; though placed by the Biographia Literaria as low as A. D. 500. an error of 800 years ! Pie applied himfelf to comparative anatomy with fome fuccefs, and invented an inftrument, which was called after him Dlo- cleus graphifeus, for the extraXion of arrow-heads. His contemporary Praxagoras rendered important fervices to medicine ; he firft difeovered the difference between arte¬ ries and veins, deferibed the cotyledons of the human uterus, and explained the phenomenon of the pulfe, a fubjeX which had been very imperfedfiy underftood by Elippocrates himfelf. It is remarked, however, by Galen, that his information was not fo correX, but that he in¬ volved himfelf in many difputes and contradiXionS. This phyfician was very fond of emetics : he adminiftered them in the iliac paflion, and in dofes fo large and fo fre¬ quently repeated, that the ftoois were ejeXed by the mouth. His furgical treatment of the fame difeafe ihows him to have been a bold and fkilful operator: Aurelian fays, that he direXs an incifion to be made through the belly and inteftines, the indurated feces to be removed, and the bowels then fowed up. The progrefs of this art now became advanced by the labours of men not exaXly interefted in its praXice. Ariftotle, who, from the unbounded liberality of his pa¬ tron Alexander, poffefled opportunities of difleXing ani¬ mals on a moft extended fcale, acquired a.mafs of infor¬ mation which we read with inftruXion and admiration even in the prefent age. Nor were his metaphyfical doc¬ trines without their influence on the philofophy of me¬ dicine ; they continued to influence it (fometimes un¬ favourably) 4 ■ 9 PATHOLOGY. favourably) for ages. The beautiful fyftem of ethics, likewife, to which Zeno and Epicurus gave birth, were not developed without a fubfequent change in this fci- ence. The tenets of Epicurus and Pyrrho were adopted by the empirical fedft, while the dogmatifts attached themfelves to the ftoical fyftem, particularly the dietetic method. For, we mull remark, that, foreign as thefe fubje&s may appear. to the pradlice of phyfic, yet its higher branches cannot be fuccefsfully ftudied without occafional reference to every branch of phiiofophy, whe¬ ther moral or phyfical. The eftabliftmient of the Alexandrian School forms an important epoch in the hiftory of medicine. But we have to regret that the deftru&ion of its fplendid library, by the hands of barbarous conquerors, has left us little to relate concerning its doftrines or its practice. We have little hefitation, however, in faying, that the advancement of medicine muft have been very great in a fituation where it derived aftiftance from long cultivation of its principles in Greece, Egypt, and India, a fituation too where fcience in general was patronifed with fo much earneftnefs by illuftrious kings. Moreover this city of Alexandria, on account of the connexion it held with all the world as a commercial emporium, muft have been frequently vilited by foreigners whole diet, clothing, ha¬ bits of life, not to mention a free communication of their own medical rules, muft have ill uftrated the fpeculations of the Alexandrian phyficians in a very luminous manner. The long feries of fafts collefted by the Egyptian priefts was here treafured up; the obfervations of the Hebrews, who, long difperfed over the plains of Aflyria and Media, had united their own medical doctrines with the tenets of Zoroafter and Ham, were examined; while the Greeks, uniting the ufeful part of this defullory and obfcure in¬ formation with the found practice of their anceftor Hip¬ pocrates, with the anatomical knowledge they were ra¬ pidly acquiring, and with their own profound phiiofophy, advanced the progrefs of the healing art in an unexampled manner. Erafiftratus and Herophilus were the firft phyficians of note in this fchool. The former flourifhed about the time of Seleucus, B. C. 270. His attention was directed for the inoft part to furgery and anatomy; but, that his medical tact was of no mean defcription, we have ample proof in the ftory told of his difcovering the love of Antiochus for Stratonice, whom Seleucus his father had then lately married. He made this dil'covery from ob- ferving, that the colour of the prince changed, and his pulfe quickened, when Stratonice entered the room, and that no fuch effects followed the prefence of any other woman. Erafiftratus was likewife confirmed in this opinion, becaufe he was unable to trace elfewhere the caufe of the prince’s extreme illnefs ; for it fhould be re¬ marked, that Erafiftratus held the lame opinion as the dogmatifts, that a difeafe could not be cured without a knowledge of its caufe. The fame incident likewife Ihows the high rank which the phyficians held in thofe days ; fince, by the influence of Erafiftratus, Seleucus was perfuaded not only to give up his wife, but alfo part of his kingdom, to Antiochus. Erafiftratus fuppofed that inflammation was produced by the coagulation of blood in the fmall arterial veflels. In his practice he was fond of Ample remedies, more efpe- cially of J'uccory ; and he even delcended to defcribe the beft mode of boiling it. He taught that medicines did not operate on the bowels by attraction, as had been fuppofed ; and that the humours which they difcharged were not the lame in the body as they appeared after their evacuation, but were altered by the adtion of thofe remedies. To purging, however, he had an objedlion, and fupplied the want of it by clyfters. Emetics were frequently prefcribed by him ; and he recommended abltinence in a great de¬ gree. Venefedtion he difapproved of for fome very fool- ilh reafons ; among which, it may be fuflicient to mention, ift. That we cannot fee the vein; 2dly. That we may Vol. XIX. No. 1283. cut the artery ; 3dly. That we do not knowhow much to take. His attachment to his theory of inflammation was the principal theory, however, why he objedted to bleed¬ ing, becaufe it did not appear to him, that the abftradtion of blood was likely to relieve the coagulation of that fluid in its veflels. Some very barbarous adds are related of this phyfician ; for inltance, that he fometimes cut open the bodies of pa¬ tients afflidted with complaints of the liver, and applied remedies immediately to the fubftance of that organ. Yet he objedted to the operation of parucentefis, or tap¬ ping, becaufe he conceived that, the water being evacu¬ ated, the furrounding vifcera would prefs upon the liver, and produce fatal confequences. He had a notion, that death changed the ftrudture of the body, as well as^the relation of its parts. In this opinion he was ftrongly fup- ported by Herophilus; and we turn with horror from the contemplation of 600 victims whom thefe barbarians are reported to have difiedted alive, and blulh that fuch a re¬ cord fhould be found in th.e annals of medicine. Yet the refined Celfus, after enumerating the advantages which accrued from this atrocious deed, excufes the cruelty of it by obferving, that “It cannot be juftly deemed cruel to put a few guilty individuals to torture, with a view to afcertain means of relief for all the innocent among man¬ kind in all fucceeding ages.” Herophilus added, to the anatomical refearches in which he aflifted his contemporary, an intimate acquain¬ tance with pharmacy. He made ufe of a great number of medicines, both Ample and compound. In his works, we find the firft mention of a difeafe which he calls palfy of the heart ; it produced fudden death, and it has been fup¬ pofed that this muft anfwer to what we now call angina pedoris. About this period, according to Celfus, the practition¬ ers of medicine w'ere formed into three divifions: 1. Thofe who attended to diet, regimen, and domeftic ma¬ nagement, who were particularly careful to diftinguifh the caufes and fymptoms of difeafes, and were of the firft rank. 2dly. Thofe who adminiftered remedies, in the preparation of which they affeCted to be particularly care¬ ful. And, laftly, thofe who performed the operations of furgery. Anterior to this time, the preparation of medi¬ cine among the Greek phyficians was entrufted to their or ftudents, as well as the chirurgical depart¬ ment, though the latter was often executed by the phy¬ ficians themfelves. The combination of the three branches continued, however, for ages, in a few inftances, among the Greeks, the Romans, and the Arabians. The Romans, as Pliny affures us, had continued without phyficians, if not without phyfic, during a period of 600 years. The few manual operations which W'ere found indifpenfably necefiary were performed by their Haves or freedmen ; and inftances are not wanting, in which their ficill was rewarded by the honour of citizen- fh ip. On the occafion of a deftruClive epidemic, in the year 463 A.U.C. however, they fent a deputation to the temple of ZEfculapius at Epidaurus. Inftead of an oracle, they received one of the facred ferpents ; and, following the indication of its fpringing from the fhip upon theifland of the Tiber, they there founded a temple to the god of medicine, and eftablifhed his worfhip on the fame footing as at Epidaurus. Shortly afterwards, a temple was dedi¬ cated to the Grecian Hygeia, and the worfhip-of Ifis and Serapis was borrowed from the Egyptians : but, befides thefe, the Romans afterwards ereCted fanes in honour of medical deities peculiar to themfelves. A prevalent dread of certain maladies caufed them to offer up prayers to the deities who were fuppofed to inflict them. Hence they worftiipped Febris on the Palatine Mount, and Mephitis at Cremona. They had likewife a goddefs Offipaga, who prefided over the growth of bones, and Carna, who took care of the vifcera, and to whom they offered bacon and bean-broth, as being nutritious articles of diet. The firft perfon who praftifed medicine at Rome in a regular man- D ner. 10 PATHOLOGY. ner, was one Archagathus, a Greek, B. C. 219. The Roman fenate at firft Teemed to give him much encou¬ ragement, and even bought a (hop Tor him, and prefented him with the freedom of the city. But his frequent ufe of the knife, and of the adtual cautery, Toon brought him into difrepute. The populace were loud in their clamours againlt his cruelty, attached to him the name of Carriifex, Butcher, and eventually baniflied him from Rome. Afclepiades, of Prufa in Byth.ynia, was the next phy.fi- cian of note who appeared at Rome after Archagathus, hut feparated from him “ longo intervallo.” He had ftudied at Alexandriaand Athens, and came toRome,in the 654th year A.U.C. or 100 years before the Chriltian era, as a teacher of rhetoric: but, not finding that profeflion fufficiently lucrative, he fuddenly turned phyfician ; and, by his confummate addrefs, in a fhort time brought him- Telf into great notice. The prototype of all fucceeding quacks, Afclepiades affefted to contemn every thing that had been done before him — “ omnia abdicavit ; totamque medicinam, ad caufam revocando, colijedturam fecit.” He ridiculed Hippocrates for his patient obfervation of nature, and called his fyftem “a meditation on death.” His fame, however, would have been incomplete, if he had not introduced a fyftem of his own. Accordingly, taking for the bafis of it the philofophy of Epicurus and Heraclides of Pontus, he attempted to explain all the functions of the human body, and all the operations of health and difeafe, by means of eorpvjcles and pores. He aflerted, that matter confidered in itfelf was of an un¬ changeable nature; and that all perceptible bodies were compofed of a number of final ler ones, between which there were interfperfed an infinity of final! fpaces totally void of all matter. He thought that the foul itfelf was compofed of thefe fmall bodies. He laughed at the prin¬ ciple called Nature by Hippocrates, and alfo at the ima¬ ginary faculties faid by him to be fubfervient to her ; and Hill more at what he called Attradion. This laft principle Afclepiades denied in every inftance, even in that of the loadftoneand fteel, imagining that this phenomenon pro¬ ceeded from a concourfe of corpufcles, and a particular difpofition or modification of their pores. He alfo main¬ tained, that nothing happened or was produced without fotne caufe ; and that what was called nature was in reality no more than matter and motion. From this laft principle he inferred that Hippocrates knew not what he faid when he fpoke of Nature as an intelligent being, and aferibed qualities of different kinds to her. For the fame reafon he ridiculed thedodlrine of Hippocrates with regard to crifes; and aflerted that the termination of difeafes might be as well accounted for from mere matter and motion. He maintained, that vve were deceived if we imagined that Nature always did good ; fince it was evident that (lie often did a great deal of harm. As for the days particularly fixed upon by Hippocrates for crifes, or thole on which we ufually obferve a change either for the better or the worfe, Afclepiades denied that fuch alterations happened on thole days rather than on others. Nay, he alferted that the crifis did not happen at any time of its own ac¬ cord, or by the particular determination of nature for the cure of the dilorder, but that it depended rather on the addrefs and dexterity of >lve phyfician ; that we ought never to wait till a diftemper terminates of its own accord, but that the phyfician by his care and medicines mull haften on and advance the cure. He accufed Hippocrates and other ancient phyficians of “attending their patients rather with a view to obferve in what manner they died than in order to cure them;” and this under pretence that Nature ought to do all herfelf, without any afiiftance. The practice of Afclepiades was principally geftation, fridtion, and the ufe of wine.' By various exercifes he propofed to render the pores more open, and to make the juices and fmall bodies, which caufe difeafes by their re¬ tention, pafs more freely ; and, while the former phyficians had not recourfe to geftation till towards the end of long- continued diforders, and when the patients, though en¬ tirely free from fever, were yet too weak to take fuffleient exercife by walking, Afclepiades ufed geftation from the very beginning of the moll burning fevers. He laid it down as a maxim, that one fever was to be cured by another; that the ftrength of the patient was to be ex- haufted by making him watch and endure thirft to fuch a degree, that, for the two firft days of the diforder, he would not allow them to cool their mouths with a drop of water. Celfus alfo obferves, that, though Afclepiades treated his patients like a butcher during the firft days of the diforder, he indulged them fo far afterwards as even to give directions for making their beds in the fofteft manner. On feveral occafions Afclepiades ufed fridlions to open the pores. The dropfy was one of the diftempers in which this remedy was ufed; but the moll fingular at¬ tempt was, by this means, to lull phrenetic patients afleep. Though he enjoined exercife fomiuch to the fick, he denied it to thofe in health ; a conduit not a little furprifing and extraordinary. He allowed wine freely to patients in fevers, provided the vioience of the diftemper was fomewhat abated. Nor did he forbid it to thofe who were afflicted with a phrenfy : nay, he ordered them to drink it till they were intoxicated, pretending by that means to make them deep; becaufe, he faid, wine had a narcotic quality and procured fleep, which he thought ab- folutely neceflary for thofe who laboured under that dif¬ order. To lethargic patients he ufed it on purpofe to excite them, and roufe their fenfes : he alfo forced them to fmell ftrong-feented fubftances, fuch as vinegar, caftor, and rue, in order to make them fneeze; and applied to their heads cataplafms of muftard made up with vinegar. Befides thefe remedies, Afclepiades enjoined his pa¬ tients abftinence to an extreme degree. For the firll three days, according to Celfus, he allowed them no ali¬ ment whatever; but on the fourth began to give them victuals. According to Caslius Aurelianus, however, he began to nourilh his patients as foon as the acceffion of the difeafe was diminilhed, not waiting till an entire re- mifflon ; giving to fome aliments on the firft, to fome on the fecond, to fome on the third, and fo on to the feventh, day. It Teems almoll incredible to us, that people Ihould be able to fall till this laft-mentioned term; but Celfus allures us, that abftinence till the feventh day was en¬ joined even by the predeceflors of Afclepiades. The divifion of difeafes into acute and chronic appears to have originated with him. The remedies which he employed (as we have feen) were chiefly dietetical ; but he was no enemy to phlebotomy, though he dilcouraged vomiting and purgation: inftead of the latter he recom¬ mended clyfters. He was a great advocate for the ufe of cold water externally as well as internally; though he probably ingratiated himfelf with the Romans more by his free adminillration of wine in diforders where it had not formerly been allowed. Sprengel fuppoles him to have been the inventor of the balnea penjilis, or Ihower-bath. That: Afclepiades, notwithllanding his arrogance, was a man of obfervation and difeernrnent, is evident from his defeription of difeafes ; and from the faCl, that he always continued to enjoy great reputation among the Roman people, and l^iat his leClures, which, according to Pliny, embraced the three branches of pathology, midwifery, and pharmacy, were very numeroully attended. Galen accufes him of humouring the caprices of his patients at the expence of his own better reafon and judgment. The principles of this author’s pathology gave the firft outline of the methodic pradlice of phyfic, which was more fully developed by Themifon and Theflalus, and afterwards by Soranus. The Methodics, or Methodists, endeavoured to fleer a courfe unconnedled with the Dogmatifts or the Empirics. They objedled to the former fedl, on account of their hypothetical principles; and to the latter, on ac¬ count of the tedious manner in which they acquired their knowledge. In confequence of this, they began to claffify and generalize ; and obferved, as they conceived, two PATH two dates or conditions of body which attended all forts of complaints. To one of tliefe dates they gave the name of fir icl urn, which implied a general conftridlion of the whole body; to the latter, the epithet of luxum, by which they meant a correfponding relaxation. Cafes, however arofe, that were not referrible to either of thefe claffes : confequently, the Methodifts were obliged to in¬ vent a third, which partook of the properties of both the others. Hence they admitted the contradiftion of a (late of relaxed contraction, an expreffion of which no conception can be formed. It has been fuppofed, however, by M. Cabanis, that this mixed (late of laxutn and JlriClum meant an irregular dif- tribution of vital power, or irregularity of tone. If his idea be corredl, this clafs would comprehend all difeafes, without the afliftance of the other two ; for we know of no difeafe that is not marked at times by an unequal dif- tribution of vital energies. As to the praSice of the me¬ thod ills, it may be obferved, that they wholly overlooked the healing powers of the fyltem, and, without regard to the peculiar circumftances of the cafe, or the nature of the part affedled, were l'olely intent on fulfilling thofe general indications that were conformable to their theo¬ ry. It is true, that they paid particular attention to days ; not, however, as connedled with the dodlrine of criles, for which the founders of this left entertained a marked contempt ; but only as affording them a meafure of the duration of the diforder, and a guide for the method of treatment. In the firft days, they followed the llarving fyftem ; afterwards they purfued the fuppofed general in¬ dications of conftri&ing, or of relaxing: during the ex¬ acerbation of the difeafe, they endeavoured to moderate the violence of it ; during its decline, they fupported the powers of the fyllem by nutritive diet. This was their mode of proceeding in all acute difeafes : but, in chronic complaints, to which it was lefs applicable, they had re- courfe to what they termed the ^T-oco-vyr.^ait, or re-in¬ corporation, of which the profeffed object was to reltore the proper relations between the atoms and pores, and for which they prepared the patient by the ocvx or re- fumplrtie circle. It was, in fadl, little elfe than their practice in acute difeafes reverfed : they firft fought to ftrengthen the patient by a generous diet, and then they adminiftered a fucceffion of violent remedies, to fubdue the original malady. Among the difciples of Themifon, one Theflalus of Trallis, a man of low birth and coarfe manners, made himfelf confpicuous by the fhamelefs audacity with which he fought to difparage the labours of others, arrogating to himfelf the title of I&t ^ony.ri;, or Conqueror of Phy- ficians, and that, it would appear, without the flighted: pretenfions to either learning or talents. (Plin. xxix. i.) He held forth, that he could qualify any one for a phy- fician in the fpace of fix months, and aftually fucceeded in obtaining a great number of pupiTs ; but they were from among the lowed order of artifans, fuch as rope-makers, weavers, cooks, butchers, fullers, and fuch like. Thefe he took with him to vilit his patients for the ftipulated time; and then he conferred upon them the privilege of pradlifing for themfelves. From his time it became the cuftom for the Roman phyficians to vifit their patients attended by all their pupils; in allufion to which, we have the epigram of Martial : Languebam ; fed tu eomitatus protinus ad me Venifii, centum , Symmache, dijcipulis. Centum me tetigere manus aquilone gelata : Non habuifebrem , Symmache : nunc habeo ! I’m ill. I fend for Symmachus ; he’s here. An hundred pupils following in his rear. All feel my pulfe with hands as cold as fnow : I had no fever then ; I have it now. The methodic fcliool acquired much greater repute from the labours of Soranus and Caelius Aurelianus. The former a native of Epliefus, who had ftudiedat Alex- O L O G Y. 11 andria, and came to Rome during the reign of Trajan ; the latter an African by birth. Free from the prejudices which had difgraced his predeceffors, Soranus cultivated the ftudy of anatomy, and wrote a book on the female organs of generation, which is dill extant, and difplays conftderable acquaintance with the fubjedt. Many of his obfervations (how that he was pofleffed of great fagacity and ftrength of judgment. To Cadius Aurelianus, on the other hand, we are indebted for an account of his doc¬ trines and pradlice, and for one of the bed works on me¬ dicine which have come to us from ancient times ; writ¬ ten it is true, in a barbarous ftyle, but highly deferving of perufal, on account of the accurate defcription of dif¬ eafes,. and the different methods of treatment, which it contains. Anatomy and the other auxiliary fciences, though they had been fo much negledled by the Methodifts, were now receiving important additions from other quarters. Rufus of Ephefus, who lived in the time of the emperor Trajan, applied himfelf zealoufly to the dilTe<5lion of ani¬ mals, particularly of apes, and defcribed from analogy the different organs of the human body. Fie traced the nerves from their origin in the brain, and divided them into- thofe of fenfation and thofe of voluntary motion. The heart he believed to be the feat of life, of animal beat, and the caufe of pulfation ; and he (bowed the difference of ftrudlure and capacity between the right and the left ventricle. The fpleen he held to be an ufelefs organ. Marinus, whom Galen calls the reftorer of anatomy, and to whofe labours he was himfelf probably indebted for much of his knowledge on the fubjedl, rendered dill greater fervices to the fcience. He inveftigated the ab¬ sorbent fyftem with great care, and difcovered the me- fenteric glands ; he diftributed the nerves into feven pairs: the N. palatinus (then called the fourth pair) was firft defcribed by him; and he is faid to have been the dif- coverer alfo of the par vagum, which he termed the fixth pair. Flis numerous writings have all perilhed. The ftudy of the materia rnedica, and of the other branches of natural hiftory, was profecuted with no lefs vigour ; and we owe to the firft century of the Chriftian era the invention of many remedies which are (till retained in our pharmaceutical fyltems. The elder Pliny, fecond only to Ariftotle in the univerfality of his genius, but furpafiing even that great man in his infatiable third for knowledge, had collected in his Hiftoria Mundi all that the ancients knew of natural fcience. Diofcorides of Anazarba, devoting himfelf to botany and materia rae- dica, produced a work which ferved for a guide in thefe fciences till a very late period. His defcriptions of fome of the more valuable drugs, fuch as myrrh, laudanum, af- fafoetida, ammoniac, opium, fquills, and their different preparations, are entitled to great praife. The efficacy of feveral remedies, which he recommends, has been ad¬ mirably confirmed by later experience, fuch as of the elm-bark in cutaneous difeafes, of potafti as a cauftic, of the male fern againft worms, &c. &c. Some of the con¬ temporaries of Diofcorides, as Scribonius Largus, Xeno- crates, and Andromachus, cultivated the materia rnedica, but with lefs fuccefs. To Menecrates, who lived in the reign of Tiberius, and who, according to an infcription in Montfaucon, appears to have been the author of 15s books, we are indebted for the invention of the diachy- lon-plafter; and Damocrates is well known as the author of feveral complicated remedies which bear his name. Herennius Philo, of Tarfus, is mentioned by Galen as the inventor of an anodyne compofition, called, after him, Philonium, and which confided of opium, euphor- bium, and different aromatics ; and Afclepiades Pharmacion was the introducer of numerous remedies from the animal kingdom, which, though long honoured with a place in our pharmacopoeias, have now defervedly fallen into difrepute. Before quitting this period of medical hiftory, it will be neceflary to fay a few words refpedting two other fedls, which 12 PATHOLOGY. which arofe foon after the eftablilhment of the Methodic fchool : we mean the Ecledic and Pneumatic feds. The founder of the latter, Ariftseus of Cilicia, flourilhed as a phyfician at Rome about the middle of the firft: century, and diftinguilhed himfelf by his oppofition to the-tenets of Afclepiades, and his attachment to the Stoical fyftem : he extended the theory of pre-exiftent germs ; treated the dodrine of the pulfe with dialedic fubtlety, referring its varieties to the exhalation of the nvBv^a. from the heart and arteries ; and cultivated feveral branches of patholo¬ gy ; but was more fuccefsful in his dietetic researches, particularly with refped to the influence of the atmof- phere. His pupil Agathinus, endeavouring to reconcile his principles with thofe of the Methodic and Empiric feds, acquired the name of Epifynthetic or Ecledic; and thus eftablilhed the Ecledic fyftem, on which, however, he does not appear to have conferred much repute by his own labours. That merit was referved for Archigenes and Aretasus, who, adopting the leading tenets of the Pneumatic theory, gave it a more fcientific form, and enriched it by many valuable obfervations. The former attempted to reform the language of medicine, but with¬ out much effed 5 for even Galen has occafion to complain of the obfeurity of his phrafeology ; he was, befides, too fond of fubtleties: but many of his practical obfervations, which Galen has recorded, are excellent. The merits of Aretasus, as a tkilful and attentive obferver, and as an elegant deferiber of difeafe, are familiar to every one. To Caflius the Iatrofophilt, another Eclectic, we are in¬ debted for many valuable pathological remarks concern¬ ing the difeafes of afi’oeiation, and the fympathies of the nervous fyftem. On the fubjed of Aretasus and Archigenes, Dr. Huxham has the following note. “ It is pretty furprifing that none fliould take notice of Aretasus Cappadox before Aetius Amidenus, in the fifth century; (he is indeed named in the Euporifta attributed to Diofcorid.es, but few think that piece to be the genuine work of that au¬ thor.) Neither Galen, Caslius Aurelianus, nor Oribafius, mention him; though fo particular in enumerating all the phyficians of note, antecedent to, or cotemporary with them. And yet Aretteus feems to have been a very confiderable practitioner, and a man of great learning and judgment : he aft'eds a very Angular ftyte, ufing many oblolete words, Homeric and Hippocratic phrafes, and the Ionic dialed ; which, at the time he wrote in, was almoft entirely difufed : for, notwithftanding the conceit of Voflius, he undoubtedly did not write till after the time of Nero. All this one would think fliould have made him remarkable ; efpecially if he praCtifed in or near Rome ; which is not improbable, as he advifes Roman wines to the lick ; particularly the Falernian, Surrentine, Signine, and thofe of Fundi. But Galen and Aetius quote from Archigenes feveral paffages, which are exadly the fame, as to fenfe, dodrine, method of cure, and manner of expreflion, with what we find in Aretasus ; only the latter gives them the Ionic turn. They both coincide in recommending fome particular medicines, which are fcarce to be met with in any others, particularly the external ufe of cantharides ; which I think is not to be found in any preceding author, except Celfus. Did Archigenes then borrow from Aretasus, or the latter from the former? It is certain, Archigenes pradifed at Rome with a very great reputation, was a very celebrated phyfician and author, and as fucli is re¬ ferred to by Juvenal, Galen, Caslius, Oribafius, Aetius, Sec. He is ftridly criticifed by Galen, fometintes cen- fured, fometimes commended, but never reckoned a mere compiler. Aretasus, on the contrary, is mentioned by none but Aetius and Paulus Avgineta; nay, which is not a little to be wondered at, he is not fo much as found in Photius’s Bibliotheca. This is really ftrange, and not eafily accounted for, and would incline one to think that Aretasus borrowed from Archigenes ; or ra¬ ther tranferibed and new-modelled him, giving him the Hippocratic didion and Ionic dialed. Poftibly Aretteus might do by Archigenes fomething like what Caslius Aureliar., not long after, did by Soranus: but, iffo, he hath vaftly much better grascifed Archigenes than Caslius hath latinized (as he calls it) Soranus. Upon this fuppo- fition, we need not wonder at finding the Roman wines recommended in Aretasus, though lie might pradife and write in Cappadocia, or any where elfe, at the greateft diftance from Rome. Be the matter as it will, in Aretasus we have a molt valuable work, a moft accurate defeription of difeafes, and in general a very proper and judicious method of cure ; and it is greatly to be lamented, that the work comes fo maimed to us.” Huxham on Fevers, Pref. During this period, furgery received confiderable im¬ provement; particularly from the labours of Heliodorus and of Antyllus. Of the former, who was an eminent furgeonat Rome in the time of Trajan, Nicetas has pre- ferved feveral pradical obfervations on injuries of the head and difeafes of the bones, which evince no mean profi¬ ciency in his art. The latter is perhaps (till more deferv- ing of notice, as being the firft who gives any account of the extradion of the catarad : he recommends this ope¬ ration to be performed while the catarad is final!, being of opinion, that, when enlarged, it cannot be extraded without bringing the humours of the eye along with if. His diredions concerning the preparation of plafters and ointments, and concerning the choice of veins in phle¬ botomy, are very minute. In dangerous cafes of cynunche, he advifes bronchotomy ; and in hernia humoralis he ope¬ rated by incifion. Philagrius, who lived about the time of Valens, appears to have been the firft who attempted to extrad a ftone from the bladder by the high operation. Aetius has alfo tranfmitted to us an account of the fur- gical pradice of one Leonides of Alexandria, whofe ob¬ fervations on hernia, fcrofula, and glandular fwellings, on hydrocele, and on inflammation of the ferotum, fhow confiderable difeernment. In canceroqs affedions of the bread, he reforted to amputation, and the adual cautery ; in fiftula, his method of operation differed but little from that recommended by Pott. Having difpatched feveral names of fmaller eminence, we now come to the illuftrious Celfus, who lived at Rome, as fome think, about the reign of Tiberius. His native place is unknown ; and many writers have fuppofed that lie was never in pradice. Yet his minute deferiptions of many pharmaceutical preparations could hardly have been acquired unlefs he had compounded them with his own hands; nor could his excellent diredtions in furgery have been penned without fome knowledge of the manual operations. In many parts of his works, he follows the Father of Medicine fo clofely, that he has been called the Latin Hippocrates ; though that name is equally appli¬ cable to him on account of the purity of his language. (See Celsus, vol. iv.) In his work on furgery, all the improvements from Hippocrates to his own days are colleded ; the moft mi¬ nute and trifling difeafes are not omitted. An eminent furgeon of the moderns emphatically exhorts every perfon in that profeflion “ to keep Celfus in his hands by day and by night.” He follows Hippocrates, but with much improvement in his chirurgical diredions ; efpe¬ cially in the mode of trepanning, in applying fplints, bandages, Sec. in the manner of extending and fixing fradured limbs and likewife in the medical treatment of the patient. In luxations of the fhoulder, he mentions feveral methods of giving force to the extenfion, and of replacing the diflocated bone. One method fimilar to that of Hippocrates was, to fufpend the patient by the arm ; the fore part of the fhoulder, at the fame time, refting upon the tep of a door, or any other fuch firm fulcrum. Another method was to lay the patient lupine, fome af- fiftants retaining the body in a fixed pofition, and others extending the arm in the contrary diredion ; the furgeon. PATHOLOGY. in the mean time, attempting, by his hands, forcibly to reduce the bone into its former place. He made the diltin&ion into fnnple and compound fractures, as it exifts in the prefent day ; and his direc¬ tions in the cure of fractured ribs are extremely judicious. The different fpecies of hernias are well defcribed by him ; and he feems to have pfed a bandage and comprefs after the reduction of the bowels, on the fame principle as we now ufea trufs. In fome cafes, after the return of in- teftitial ruptures, he diminiflied the quantity of loofe fkin, and formed a cicatrix, fo as to contract over the part, to render it more rigid and capable of relilting. He defcribes various dil'eafes of the genital parts, the hy¬ drocele or dropfy of the fcrotum, a difficulty of urine, and the manner of drawing off the water by a catheter ; the figns of ftone in the bladder, and the method of founding or feeling for that ftone. Lithotomy was at that time performed by introducing two fingers into the anus ; the done was then preffed forward to the perinteum, and a cut made into the bladder ; and by the finger or by a fcoop the ftone was extracted. He defcribes the manner of performing this operation on both the fexes, of treat¬ ing the patient, and the figns of recovery and of danger. Celfus gives excellent inltruftions with regard to in¬ flammation in general ; and mentions fome ufeful topical applications in ophthalmia. The operations for the cata¬ ract (which confifted in depreffing the cryftalline lens), and for fiftula, are likewife defcribed by him ; as alfo the mode of performing the operation of paracentefis. The external application of arfenic as a cure for cancer origi¬ nated with Celfus. In external gangrene, he cut into the found flefli ; and, when the difeafe, in fpite of every effort, fpread, he advifed amputation of the member. After cutting to the bone, the fleffi was then feparated from it, and drawn bach, in order to fave as much fleffi as poffible to cover the extremity of the bone. He de¬ fcribes the fymptoms of that dangerous inflammation the carbuncle, and direfls immediately to buril or corrode the gangrened part. To promote the fuppuration of abfceffes, he orders poultices of barley-meal, or of marffimal- lows, or the feeds of linfeed and fenugreek. He alfo mentions the compofitions of feveral repellent cataplafms. In the eryjipelas, he applies cerufe, mixed with the juice ofSolanum, or nightlhade. He is very diffufe in thofe parts of his works which relate to pharmacy, giving for¬ mula for a great many external and internal remedies now' defervedly aboliftied. Though Celfus followed the praClice of Hippocrates in many refpefts, yet he very much differed from him in others. He particularly ridiculed his dodtrine of critical days, which he attributed to anabfurd application of the Pythagorean dodlrine of numbers ; and he differed from that phyfician in regard alfo to bleeding; for he held it dangerous to take much blood from patients at once, and rather preferred the abllradlion of it at repeated intervals. In regard to abflinence, he feems to have followed Afclepiades, enjoining the fick to endure hunger and thirft during the firft days of their illnefs, and afterwards allowing them plenty of food. He entirely difregarded the indications of the pulfe, from having obferved that it was accelerated or depreffed by many adventitious cir- cumllances, as well as from having found it very different in complaints of a fimilar nature. The moft confiderable of the Roman pathologifts, and the laft of any great eminence, was Galen, who flourilhed about a hundred and thirty years after Celfus, and was phyfician to the emperor Marcus Aurelius. This great man was confidered for many centuries afterwards the moft infallible authority in all matters relating to patho¬ logy. Impreffed at an early age with the important truths contained in the writings of Hippocrates, he viewed with contempt and difguft the jargon and obfcurity which en¬ veloped them in the fchools of medicine. Accordingly he became lrimfelf the expofitor of Hippocrates. He re¬ peated and extended his obfervations, prefented his opi- Vol. XIX. No. 1283. 13 nions in new lights, and fupported his dodtrines with all the aids which w'ere derivable from fpeculative reafoning or the comparifon of fadls. Yet Galen in fome meafure fell into the fame error of which he accufed his predecef- fors and contemporaries. He obferved the naked faffs and fimple truths related almofl without comment by the coarle fage. He applied himfelf too much to explain, arrange, and fyftematize, a very fmall ftock of informa¬ tion ; and, by endeavouring to illullrate a very uncertain fcience by means of others not more exadl, he permitted his imagination to frame hypothefes in the higheft degree gratuitous and aflumptive. Thefe obfervations are fully exemplified by the following Iketch of his fyftem. He firft begins with eftablilhing four qualities in the ani¬ mal body; heat, cold, moifture, and drynefs. The pe¬ culiar combinations which thefe qualities undergo, or in other words the changes which may be rung on them, pro¬ duce eight conftitutions, or temperaments; i. e. hot, cold, moilt, and dry ; hot and moift, cold and moift, hot and dry, and cold and dry. (See Galen, vol. viii.) Idiofyncracy is that temperament which cannot be referred to any of thefe qualities, and is therefore fuppofed to arife from occult caules. With Hippocrates, Galen admitted the operation of Nature ; but to this agent he added three other faculties, or, as we thou Id call them, vital properties. The firft and molt important, he calls the animal faculty ; it has its feat in the brain, .performs the operations of mind, and by means of the nerves diftributes the proper¬ ties of motion and fenfation to all parts of the body. The fecond is called the natural faculty ; it has its feat in the liver, and is the principal agent in giow’th, generation, and nutrition. The third, denominated the vital facul¬ ty, is lodged in the heart, and from thence, by means of the arteries, dilleminates heat and vitality through the whole fyftem. Thefe three faculties were adled upon by Nature as a primum mobile. Their production was fuppo¬ fed to be owing to the agency of certain Jpirils, or faille vapours, which he likewife divided into three kinds, bear¬ ing the names of vital, natural, and animal. Galen ad¬ mits the exiftence of the four humours of blood, phlegm, yellow, and black bile, firft infilled on by Hippocrates. With that phyfician he likewife divides the body into three component parts ; fpirits, humours, and parts, or, as we call them ,folids. The laft-inentioned fubllances he divides into organical and fimilar. It were ufelels to enter into a detail of the minute diftinc- tions of difeafesand their caufes in which Galen has in¬ dulged. Suffice it to fay, that the increafe, deficiency , or ir¬ regular diftribution,of the different humours,qualities,&c. which we have enumerated, was regarded by him as the eflential caufe of difeafe ; confequently the abllradlion of redundant, the reproduction of deficient, or the correc¬ tion of peccant, humours, formed the principal indications in his pathology. In anatomy and phyfiology, Galen dil- covered or arranged many important fadls. His affiduous diffedlions of animals furnifhed him with many ufeful ob¬ fervations : he likewife preferved in his writings much of the anatomical knowledge of the Alexandrian fchool ; and has indeed corrected by experiment the errors into which that fchool had fallen, particularly in regard to the circulation of the blood. Hippocrates had afierted, that all the veffels communicated with each other, and that the blood underwent a kind of flux and reflux to and from the heart, like the ebbing and flowing of the lea; and he mentions the throbbing of the temporal arteries, as an evidence of this fail. The.anatomifls at Alexandria had adopted a different ©pinion ; as they found the ar¬ teries empty, and the veins containing blood, in their diffedlions, they imagined that the former were tubes for the diftribution of air, (and gave them that name which they have borne ever fince;) and that the veins were the only channels for the blood. The heart of man confid¬ ing of two lets of cavities not communicating with each other, and its connexion with the lungs, were to them delufive circumftances, and feemed to favour their opi- E nions. 34 PATHOLOGY. nions. If is true they fometimes found blood in the ar¬ teries, and in the left cavities of the heart ; but then they believed that the air or fpirit had efcaped, and that the blood had oozed through the fides of thefe air-veflels, and fupplied its place. Galen refuted this opinion by expe¬ riment. He laid bare one of thefe vetfels in a living ani¬ mal, and by tying it in two places, and opening it between the ligatures, he afcertained that it contained blood and nothing elfe. He therefore concluded, that both veins and arteries ferved the fame purpofe-, that of diftributing blood for the fupply of the body, but that the florid ar¬ terial blood contained more air than the purple blood of the veins. We need hardly remark, that Galen did not underhand the natural courfe of the blood, though he had thus made known its containing vefl'els. Galen did not apply himfelf much to the furgical de¬ partment of the art : however, he occafionally performed the operation of arteriotomy, and opened the jugular veins ; and he defcribed with accuracy the different kinds of hernia. In a hiftory of this kind it feems right to mention the effect of anatomical ftudies on the mind of Galen. After contemplating the ftrufture of the bones of a fkeleton, and their "adaptation to their different fundiions, he breaks out into an apoftrophe, which has been much ad¬ mired, and in which he isfaid to have exceeded any an¬ cient in pointing out the nature, attributes, and proper worfhip, of the Deity. “In explaining thefe things,” he fays, “I efteem myfelf as compoiing a folemn hymn to the author of our bodily frame ; and in this I think there is more true piety than in facrificing to him heca¬ tombs of oxen, or burnt-offerings of the moft coftly per¬ fumes : for I firffc endeavour to know him myfelf, and af¬ terwards to (how him to others, to inform them how great is his wifdom, his virtue, his goodnefs.” Medicine improved very flowly after the time of Galen ; his fucceflors were more employed in compiling and com¬ menting on the works of their predeceflors, than in en¬ deavouring to extend the bounds of fcience by original obfervation. Among the moft diftinguilhed of thefe we may record the names of Oribaftus, Aetius, Alexander Trallian, and PaulusAEgineta. Oribafius flourifhed about the year 360, and was phy- ffcian to the emperor Julian. Though commonly rec¬ koned a Sardian, he was born at Pergamus, and bred up, together with Magnus and Ionicus, in the ichool of Zeno the Cyprian, who taught then at Sardis, though after¬ wards he removed to Alexandria, where he became a famous profeflbr. Eunapius reprefents Oribafius as the greateft fcholar and phyfician of his time, and a very en¬ gaging and agreeable man in converfation. He defcribes him as no lefs confiderable in his intereft than in his learning : according to his account, he contributed very much to the advancement of Julian to the empire, who in return made him quasftor-of Conftantinople, and who, as appears by one of his letters, had an entire confidence in him. Ip. the fucceeding emperor’s time, through the envy of his enemies, he fell into difgrace, had all his ef- tates confifcated, was banifhed, and delivered into the hands of barbarians ; amongft whom, in a little time, by his courage and flcill, he gained fo much love and' reve¬ rence, that they, feeing what great cures he performed, adored him as a god. At laft he was recalled by the Ro¬ man emperor, and flourithed in reputation and riches at the very time when Eunapius wrote this account, which muft be near the year 400. Oribafius wrote feventy (according to Photius) or (ac¬ cording to Suidas) feventy- two books of colledtions, which he compiled not only from Galen, but from all the preceding phyficians, and his own experience, at the defire of Julian; the fifteen firft of which are only remain¬ ing, and two others treating of anatomy, Afterwards he made an epitome of this great work, and reduced it into nine books for the ufe of his fon, Eullathius. Paulus mentions this epitome ; but it is now loft, as are fome other tradfs which Suidas takes notice of. Thefe works, though chiefly compilations, are, by no means without their ufe to the medical ftudent ; for both Oribafius and Aetius have preferved fome fragments of antiquity, and thofe of fome value, which are no-where elfe to be met with ; that is, they compiled from the now-loft-vvorks of Galen and others, and added much original matter of their own. We will give only one inftance of what is either omitted by Galen, or is loft together with fome other of Galen’s works; namely, the firft defeription of the lalivary glands, which is this : “ On each fide of the tongue, iie the orifices of the vefl'els, which difehargethe fpittle, and into which you may put a probe. Thefe vef- fels take their rile from the root of the tongue, where the glands are fituated. They rife from thefe glands, in much fuch a manner as arteries ufually do, and convey the falivary liquor, which moiftens the tongue, and all the adjacent parts of the mouth.” Oribafius, lib. xxiv. c. 8. Oribafius, either from Apollonius or himfelf, fpeaks very fully of the good eftedts of bleeding by way of fca- rification, a thing little taken notice of by former writers : and allures us, from his own experience, how fuccefsful he had found it in a fupprelfion of the menfes, defluxions of the eyes, headache, lfraitnefs of breathing, even when theperfon was extremely old. He tells his own cafe par¬ ticularly, when the plague raged in Afia, and he himfelf was taken ill, that the fecond day he fcarified his leg, and took away two pounds of blood; by which method he en¬ tirely recovered, as did feveral others who ufed it. Here we may obferve, that this was a different method of fca- rifying from that performed by the help of cupping. The Arabian phyficians feem to have'had a notion only of the latter practice : but, from this place, as well as from fome pafiages of Galen, it is plain, that the ancients made deep incifions into the Ikin by the knife ; and therefore thought, by the large quantity of blood they could draw off, that this method was equivalent to opening. a vein. The Egyptians make ufe of it to this very day; and Profper Alpinus defcribes at large the apparatus : they make, firft a ftrait ligature under the ham, then rub the leg, and put it into warm water, and beat it with reeds to make it fwell, and fo fcarify. A procefs in every par¬ ticular differing from cupping ; and therefore, in the cure of giddinefs, Oribafius himfelf fpeaks of them as two diftindt operations. We find in this author the firft account of a ftrange and lurprifing diftemper Avy.a.vfya'rrix, a fpecies of melancholy and madnefs, which he defcribes thus : “The perfons af fedied go out of their houfes in the night-time, and in every thing imitate wolves, and wander among the fepul- chresofthe dead till day-break. You may know them by thefe fymptoms: their looks are pale; their eyes heavy, hollow, dry, without the leaft moifture of a tear : their tongue exceedingly parched and dry : no fpittle in the mouth, extreme thirft ; their leg', from the falls and bruifes they receive, full of incurable fores and ulcers.” Aetius gives the very fame defeription, with fome little variation ; only calls it K.v'jxvitjco'mx as well as Av/.xv^^ani and obferves it prevails moft in February. Aetius takes this paflage, as he fays, that is, makes a paraphrafe of it, from Marcellus Sidetes, an author who lived under Adrian and M. Antoninus; and who wrote forty-two books concerning diftempers, in heroic verfe. Paulus has tranforibed the fame account of this difeafe word for word. The Greek term ufed to denote this difeafe ex- prefles the nature of it veryjuftly; and yet Vanderlindenis fo carelefs a writer, that lie makes it a fynonymous term for the madnefs of the wolves themfelves. We conceive the difeafe to have been a fpecies of mania, in which the aflociation of the mind with deceafed relatives produced an inclination to wander among the tombs. Of the epilepfy, Oribafius defcribes the cure both in the acute and the chronical fort ; that is, in the fit as well as out of it. When the litis over, he orders bleeding; and. 15 PATHOLOGY. and, after four or five days, when the body is a little re- veterate afthma, after all other remedies have been tried cruited, purging ; three days after, cupping and fcarifying. in vain. One, he fays, fiiould be made on each fide, near He repeats thefe evacuations, and fometimes finapifms, at the middle of the joining of the clavicle, taking care convenient diftances, and in the intervals gives proper not to touch the wind-pipe: two other little ones are nourilhment, and ufes warm medicines, fuch as caftor, then to be made near the carotids under the chin, one on mint, rue, and the cyrenaic juice. Whether this be taken out of Pofidonius, as, by reading Aetius upon the fame head, there may be fome reafon to fufpeCt, we can¬ not tell ; but the method is certainly right, and agreeable to a rational practice. The epitome of what Galen had faid upon the fame argument, in the next chapter, is by no means fo full and circumflantial. Thefe few infiances will be fufficient to (how, that even this author, though he be chiefly a collector, may furnifii us with fome new and ufeful reflections in phyfic; and he who reads him with this view, may find fome other paflages of the fame kind, not to be met with in the more ancient writers. Aetius lived very near the end of the fifth or the be¬ ginning of the fixth century. He was a native of Amida in Me!opo.tamia, ftudied at Alexandria, and was probably a Chriftian, which perhaps may be the reafon why many have confounded him with another of that name, a fa¬ mous Arian of Antioch, who lived in the time ot Julian. In fome manufcripts he has the ftyle of Kopn; O-vJ/ixta, Comes ObJ'equii ; i.e. the chief officer of thole who ufed to go before the emperor, as his attendants and harbin¬ gers. We find in hint feveral particularities relating to the Egyptian pharmacy. He has collected a great multi¬ tude of receipts, particularly thofe which had been much celebrated, or ufed as noltrums by their inventors. Some of thefe he feems to mention with no other defign than to expofe them, and to let us fee the extravagant rate people were induced to pay for them : for inftance, the colly- riutn of Danaus, which was fold in Confiantinople for one hundred and twenty numifmata, and with great difficulty obtained from him ; the colical antidote of Nicofiratus, called very prefumptuoufly Ifotheos, bought for two ta¬ lents. He feems alfo to be the firft: Greek writer among the Chriftians who gives us any fnecimen of medicinal fpells and charms, fo much in vogue with the old Egyp¬ tians ; fuch as that of St. Blafius, in removing a bone which flicks in the throat ; and another in relation to two fiftulse. The followfing fample of a remedy for the gout is re¬ marked by Dr. Freind as being the firll ofits kind in the hiflory of phyfic. It is an external medicine : he calls it the grand dryer : the patient is to ufe it for a whole year, and obferve the following diet befides in each month. He calls the months by the Alexandrian or Egyptian names, but in Engliffi, the direction runs thus : “ In Sep¬ tember to eat and drink milk : in October to eat garlick : in November to abltain from bathing: in December not to eat cabbage: in January fo take a glafs of pure wine in the morning: in February to eat no bete : in March to mix fweet things both in eatables and drinkables: in April not to eat horfe-radifh : nor in May the filh called polypus : in June to drink cold water in a morning : in July to avoid venery : and laftly, in Augufi to eat no mallows.” This may give us fome idea of the quackery of thofe times. In the works of Aetius we find many obfervations omitted by Celfus and Galen, particularly on furgical operations and on difficult parturition. He firft took no¬ tice of the Dracunculus, or Guinea worm, not known to Galen. It is curious to remark the exceffive extent to which the aCtual and potential cauteries were carried in the time of this practitioner. In a palfy, he fays, that he fiiould not at all hefitate to make an elchar either way, and this in feveral places; one in the nape, where the fpinal marrow takes its rife, two on each fide of it; three or four on the top of the head, one juft in the middle, and three others round it : he adds, that, in this cafe, if the ulcers continue running a conliderable time, he fiiould not doubt'of a perfect recovery. He is ftill more parti¬ cular when he comes to order this application for an in- each fide, fo that the cauftic may penetrate no further than the fkin ; two others under the breafts, between the third and fourth ribs ; and again, two more backwards towards the fifth and fixth ribs. Befides thefe, there ought to be one in the middle of the thorax, near the be¬ ginning of the xiphoid cartilage, over the orifice of the rtomach ; one on each fide between the eighth andninth ribs; and three others in the back, one in the middle, and the two others juft below it, on each fide of the vertebra;. Thofe below the neck ought to be pretty large, not very fuperficial, not very deep : and all thefe ulcers fiiould be kept open for a very long time. » Alexander, who flouriffied in the reign of Jultinian, is a more original author than either of the two former. He was furnamed Trallianus, being born at Tralles, a famous city of Lydia, where the Greek language was fpo- ken in great perfection : he lived in the fixth century, fome time after Aetius. He was a man of very extend ve praftice and of great fame, whence he was emphatically called Alexander the phyfician. His therapeutical direc¬ tions are very full and explicit, aft d were chiefly the re- fults of experiments made by hirnfelf. His practice was remarkable for the judicious introduction of aperient me¬ dicines in cafes of fever, and the ufe of bleeding in fyn- cope, adifeafe which, according to his defeription, feems to apply to the epilepfy of our own times. But the molt valuable part of Alexander’s writings was his book on gout, for the cure of which he recommends purging, and particularly with the herb hermodadlylus, which is fiip- pofed to be the colchicum lately brought up again and ac¬ quiring great reputation in the. cure of the fame complaint. He is the firft author who recommended the life of- rhu¬ barb, which he had recourfe to in vveaknefs of the liver and in dyfentery. Alexander is recommended by Dr. Freind as one of the bell practical writers among the an¬ cients, and well worthy the perufal of any modern. Paulus, the fourth and laft of the old Greek writers, was born in the ifland Aigina, and lived in the feventh century, though placed by Mr. le Clerc as high as tlie fourth. He vras a great traveller, and had opportunities of feeing an extenfive practice in different countries. He tranferibes a great deal from Alexander and other phyficians. His deferiptions are fhort and accurate. He treats particularly of women’s diforders ; and feems to be the firft inftance upon record of a profeffed man-midzoije , for fo he was called by the Arabians : and accordingly he begins his work with the diforders incident to pregnant women. He treats alfo very fully of furgehy, and gives fome direClions, according to J>r. Freind, not to be found in the more ancient writers. He direCls the manner of extruding darts, and of operating for hernia ; he deferibes one fpecies of aneurifm ; treats of the mode of opening the jugular veins, and alfo the arteries behind the ear. He likewife deferibed the operation'of bronchotomy, and ftiowed the propriety of performing it in cafes of fuffoca- tion. This operation had been derided by Aurelianus, and fome fevere objections were Halted againftit by Are- taeus. It was firft; performed by Antyllus, from whom Paulus copied it. With Paulus clofes the period of the Greek clujjlcal phyficians: fo we venture to call them; becaufe, if we compare any of the Greek writers on pathology, from the very firfi of them, Hippocrates, to the time we are now fpeaking of, with the very bell of their contempora¬ ries in any art or profeffion whatever, they will be found not at all inferior to them either in the difpofition of their matter, the clearnefs of their reafoning, or the propriety of their language. Some of them have even written above the ftandard of the age they lived in ; an incon- teftible inftance ®f which is Aretseus. Galen, alfo, was not 1G PATHOLOGY. not the only bed phyfician, but the bed fcholar and cri¬ tic, of his time. So great an honour have thefe authors done to their profefiion, by being verfed in other arts and fciences as well as their own. And the great St. Bafil, whom his own continual illnefs made a phyfician, and who has a great many allufions and fimiles taken from that art, was (to ufe the words of Photius) for the neat- nefs, the propriety, the perfpicuity, and fluency, of his ityle, one of the bed writers among the fathers ; as St. Luke’s Greek comes nearer to the ancient Aandard than that of the other evangelifls. We cannot omit faying,fomething of one author more, whom we may reckon one of the ancients, though not properly a writer in phyfic ; Nemefius, bilhop of Emilia, w'ho wrote a treatife concerning the nature of man, near the end of the fourth century: becaufe his Oxford edi¬ tor afcribes two difcoveries to him, one of which was the mod conliderable that ever was made in phyfic. The firfl is concerning the bile, “ which is condituted (as Neme- iius fays) not only for itfelf, but for other purpofes; for it helps digeflion, and contributes to the expulfion of the excrements ; and therefore it is in a manner one of the nourifliing powers: befides, as a vital faculty, it imparts a fort of heat to the body. And for thefe reafons it feems to be made for itfelf ; but, becaufe it purges the blood, it feems to be formed for the fake of the blood.” Here, fays the editor, the fyflem of the bile is plainly and ac¬ curately delivered ; that very fydem which Sylvius de le Boe with fo much vanity boaded he had invented himfelf in 3658. And indeed fo far is true, that here is the intire foundation of Sylvius’s reafoning: and, if this theory be of any ufe in phyfic, Nemefius has a very' good title to the difcovery. But there follows a much more material point ; and the fame editor contends, that the circulation of the blood, an invention which tpe 17th century fo much boafts of, was known to Nemefius, and defcribed in very plain and iignificant terms, which are thefe : “ The motion of the pulfe takes its rife from the heart, and chiefly from the left ventricle of it : the artery is with great vehemence dilated and contrafled, by a fortiof condant harmony and order. While it is dilated, it draws the thinner part of the blood from the next veins, the exhalation or vapour of which blood is made the ali¬ ment for the vital fpirit. But, while it is contradled, it exhales whatever fumes it has through the whole body, and by fecret paflages. So that the heart throws out whatever is fuliginous through the mouth and the nofe by expiration.” Upon this Angle (lender proof does he attribute this great difcovery of the circulation to Neme¬ fius ; and thefe who have infided that it was known both to Hippocrates and Galen, have full as good arguments on their fide. But it is evident enough, from this very defeription, and from what the fame author fays of the liver in the fame chapter,- that it miniders nouriflnnent to the body by the veins, that Nemefius had no idea of the manner in which the circulation of the blood is really performed. To refume the thread of our hiflory, we mud come now to home other Greek writers of a lower rank and a later date: but, as the greated part of thefe contain little that is new, we lhall give a very (hort account of their works, and only be as particular as we can in adjuding their fe- veral ages ; concerning which all our authors have left us in great confufion ; though indeed this is the lefs to be wondered at, confidering that from the time of Agathias, that is, from the year 560, to the reign of Ifaac Comnenus in 1060, there is a chafm of five hundred years- in the Grecian hidory; fo that we know very little of all that interval, except what fome (lender account of the reigns of a few emperors, chiefly Mauritius and Heraciius, fur- nifhes us with. Palladius, called Sophifi or Iatrafophid, was bred, as he himfelf feems to hint, at Alexandria. We place him firfl among the more modern Greeks, but cannot agree with the Bibliotheca literaria, which computes that heflou- rifned about theyear 126. Albinus better places him after Galen, i. e. after the year 200. In fa ft, he quotes Galen very often, and it may be proved, that he lived not only after Galen, but after Afctius and Alexander too, whofe words he frequently makes ufe of. His Commentaries upon Fradlures are imperfect; however, what of them remains is enough to let us fee that we have no great lofs by it. In thofe upon the Epidemics, he with great per¬ spicuity and exadfnefs, illuflrates not only Hippocrates, but feveral paflages of Galen ; and obferves particularly, that the done increafed much in his time, and was lefs curable; and he imputes this to the luxury of the age, to much eating, and want of exercife. He is the firfl au¬ thor now extant who has treated profefledly of urine : and he has very well explained the caufes of its colour and confidence ; what didempers thefe refpedtively indi¬ cate, and what prognodics may be drawn from them. There are feveral paflages exprefled in the fame words, as we may read in a book upon the like fubjedl, falfely af- cribed to Galen. He has written in much the fame man¬ ner concerning the faeces. Stephen, the Athenian or Alexandrian, called fome- times the one and fometimes the other, from the place ei¬ ther of his birth or his refidence, wrote a commentary upon Galen’s Fird Book to Glauco; a book that does not feem to want any comment to make it more intelli¬ gible. But there is reafon to think, that the chief physi¬ cal learning of his time confided in reading upon Galen ; and Abi Olbeia, the Arabian biographer, tells us of feven Alexandrian phyficians, among which Stephanus is one, who digeded the works of Galen into lixteen books; which again, according to the different matter, they di¬ vided into feven clafles : that thefe were the only books they dudied, and that in their turn they made it their whole buiinefs to comment upon them and explain them to their auditors. And therefore it is not at all probable that he lived in the third century, as Mr. le Clerc, without any authority, fuppofes ; and, indeed, it is plain, from this very comment of Stephen, that he was much more modern, for he himfelf mentions very ancient expofitors of this particular book of Galen ; and, in flec¬ tion 140, concerning a quartan, he feems to allude to a wrong interpretation which Alexander had made of Galen’s fenfle in this place. If this writer be the fame with Stephen the chyrnid (as he is called), his age is ea- fily known, for that author dedicates his work, de Chry- fopceia, to Heraciius, and this will make his age confident with what has already been obferved. We read of a Ste¬ phen too, and an Alexandrian likewife, in this very em¬ peror’s reign, who was a famous aflrologer, and foretold the great power to which the Saracens fliould arrive, as they did in fome years after. Vanderlinden calls Stephen the lad of the old Greek authors, though, if this account of his age be true, it will appear that feveral others wrote in Greek after that time. Of thefe Nonus feems to be in order next, who com- pofed a fort of phyfic-manual, in which is contained fome (hort account of mod didempers and their cure. He in- feribes it to Condantine Porphyrogenitus ; who, accord- ingto Lambecius, was the feventh emperor of that name, the fon of Leo, and died in theyear 959, and who, as he had fome tindlure of learning himfelf, was a great patron of it. But Jer. Martius, who publiflied an edition of this author in Greek and Latin, thinks the Condantine here meant (a Porphyrogenitus as well as the other) was the fon of Condantine Ducas, who died in 1067 ; for this reafon, that Ducas, though unlearned enough him¬ felf, was an admirer and encourager of letters, and had this faying often in his mouth, “ That he had rather be en¬ nobled by learning than by fovereignty;” To which of thefe Conflantines Nonus inferibed his work, is not very material ; I (hall only take notice, that we may collect from Anna Comnena’s hidory, that in the interval be¬ tween thefe two emperors, learning was extremely de¬ clining, if not quite extindf. 4 This 17 PATHOLOGY. This epitome is little elfe than a tranfcript from Aetius, medicines, fuch as caflia, manna, fenna, myrobalans ; Alexander, and Paulus. And he is fo free with the la- the two laft he fays were brought from foreign parts to bours of his predeceflors, that he even affumes their ex- his country, i. e. from Syria and Egypt. Senna he de- perience to himfelf. He gives a particular defcription of fcribes as a .fruit, by which, no doubt, he means the fame melancholy, and, with the air of a great praftitipner, is thing as Serapion does by the vagina, and Mefue by the full of the good effects he had feen himielf from the Ar- folliculus, which contains the feed; for neither thefe au- menian lfone, and therefore prefers it to white hellebore : thors, nor Adluarius, mention any thing of the leaves; he talks very fenfibly about the bite of a mad dog, and remarks, that when once a hydrophobia comes on, he never, in all his experience, knew one recover; and yet every word in the firft cafe is tranfcribed from Alexander, and in the latter from Paulus. Michael Pfellus lived not long after Nonus, and in- fcribedthe book which he put together, Concerning the Qualities and Virtues of Aliments, to Conftantine the emperor. Lambecius thinks this Conftantine is he who is called Monomachus, and who reigned from 1043 to 1055; but if, according to his account, Pfellus died in 1078, it is at lead as probable it might be Conftantine Ducas: and what adds to the probability is, that it ap¬ pears from Zonaras, he was preceptor to Michael Ducas, that emperor’s fon. The fame Zonaras gives this writer the character of a perfon wholly unfit to have the tuition of a prince, as being not at all qualified in any fort of letters ; but Anna Comnena, who lived a few years after him, on the contrary, extols him as one who was a perfect mafter of philofophy, one of great natural parts, and of profound learning both in Greek and Chaldaic. The fame encomiums are bellowed upon him by Leo Allatius, who (by his diflertation de Pfellis) feems to be fond of this very name, and defcribes him as one of the firft rank of writers. However there is nothing to be found in his tfeatife which can do any author much credit ; for it is only a collection from the elder Greek phyficians, who themfelves collected this part of knowledge chiefly from Galen, as he had done before from Diofcorides. He was perfecuted and dripped of every thing by Nice- phorus Botoniates, turned monk, and foon after died, very old. There are many other trails writ by this au¬ thor, an account of which we may read at large in Leo Allatius. And yet, though Pfellus was fuch a compiler as has been mentioned, Simeon of Antioch, writing upon the fame fubjeCl, but indeed in a very impure ftyle, copied moftly from him, which is the more extraordinary, fince the book he tranfcribed from was then frelh in every one’s memory: for Simeon mull have been his contemporary, though no doubt younger, becaufe he dedicated this trea- tife to Michael Ducas called Paripanaceus, who religned the empire in 1078, the very year in which Pfellus, as we are informed, died. There are many other works of this Simeon, particularly we owe to him the tranflation (out of Arabic into'-Greek) of a very fantaftical book. Concerning the Wifdom of the Indians, which Perzoes, a phyfician, collected at the defire of Chofroes, king of Perfia. ACtuarius, the fon of Zachary, fo called without doubt from the employment he held as chief phyfician to the emperor, is an author of a better character than thofe we have juft mentioned. He wrote feveral treatifes, in which occur many things worth our reading. He prac- tifed at Conftantinople, and, as it appears, with fome de¬ gree of credit; his fix books concerning the method of cure being compiled for the ufe of one of the chief offi¬ cers at court, the lord chamberlain, who was fent upon an embafly into the North. Fabricius by miftake makes ACtuarius himfelf the ambaflador. Tn thefe books, though he chiefly follows Galen, and very often Aetius and Paulus, without naming them, yet he makes ufeof whatever he finds to his purpofe, both in the old and modern writers, as well barbarians as Greeks ; and, to do him juftice, we may find feveral things in him not to be met with any where elfe. Thus, for inftance, he is the firft Greek writer who has mentioned or defcribed the milder forts of purging Vol. XIX. No. 1284. and, though thefe are chiefly in ufe now, yet the pods are fometimes made ufe of too; and, by what we can learn from thefe writers were probably the only part of fenna which was then adminiftered in phyfic. Another thing which we meet with in no Greek writer before Ac- tuarius, is the mention of diftilled liquors, as diftilled rofe-water, See. See. There are not proofs clear enough to point out to us the time where we might fix the precife age of this wri¬ ter. He is commonly, but without any good authority, reckoned to have lived in the eleventh century by fome, and in the twelfth by others. Lambecius brings him down as low as the beginning of the fourteenth ; but from his ltyle we may conclude that he was more ancient ; for, if we compare him either with Pfellus or Simeon, he will appear to have a much greater purity in his diCtion ; and indeed after 1200, we lhall fcarce meet with any writer but who has fome mixture of modern Greek, or fome barbarifms taken from other languages. We have brought down this feCtion to a much later pe¬ riod than we intended, in order to complete the hillory, as far as we could ground it upon any good authorities, of the few Greek phyficians who appeared after the time of Galen. There has been a prevailing opinion that no¬ thing was done among the ancients towards advancing this art, but what is comprifed in the voluminous works of that great man. What gave the firft rife to fuch a no, tion probably might be this : that becaufe thofe who fuc- ceeded Galen did tranferibe a great deal from him, many were inclined to think, without giving themfelves the trouble of examining and comparing their writings, that they did nothing elfe but tranferibe. And no editor of thefe authors has yet taken the leaft pains to undeceive them in this point, what has been left us by way of comment, being chiefly employed in grammatical or critical remarks, without any view of explaining what relates either to the hillory or the practice of phyfic in the time of each re- fpedtive writer. But we have given fome inftances, and more might be given, where the phyficians we have been fpeaking of have defcribed diftempers which were omit¬ ted before ; where they have taught a new way of treat¬ ing old ones; where they have given an account of new medicines, both fimple and compound, and where they have made large additions in the practice of furgery. And, if thefe be any real improvements of the art, it cannot be denied but that phylic was ftill making a pro- grefs till the year 600. As to furgery in particular, we may, without derogation to the more ancient writers, affirm, that whoever carefully looks into Aetius and Paulus, will be convinced that a great many improve¬ ments have been made in that branch of pathology which are not recited in Galen or any where elfe. And in general it may be remarked, once for all, that the wri¬ ters mentioned in this period, till the beginning of the 7th century, and thofe whofe remains they have preferved, were not fuch collectors (which is commonly the cafe) as had little knowledge of the fubjedt they undertook to treat of, but were every one of them men of experience and pradtice. And, if the later Greek writers who fuc- ceeded, were perfons of a lower character, and made little advancement in the art they profelfed, it is the lefs to be wondered at, fince, for many centuries, univerfal ignorance prevailed over all the world; and it could not be expedited that phyfic fliould make any progrefs, when all other fciences and all forts of learning were almoft quite extindl, or that it fliould be exempt from the common calamities of thofe times. F II. From 18 PATHOLOGY. II. From the Dark Ages to the end of the Sixteenth Century. After the downfal of the Roman empire, and when the inundation of Goths and Vandals had almoft com¬ pletely exterminated literature of every kind in Europe, medicine, though a practical art, (hared the fame fate with more abftraft fciences. Learning in general, banifhed from the feat of arms, took refuge among the eailern nations, where the arts of peace ftili continued to be cul¬ tivated. The Arabians, from their vicinity to Alexandria, from their intercourfe with the fed! of Neltorians and with the Greek philofophers, who had been compelled by the perfecution of Jultinian to take refuge in the Ma¬ hometan dates, had acquired a tafte for literature and the fciences. The knowledge which they polTeffed of medi¬ cine is a fubjedt of curious inquiry. In the anatomical branch, they did little more than tranflate and paraphrale the Greek w riters. The errors which their originals had made in anatomy became facred ; and, if the Arabs have defcribed certain parts of the body with more exadtnefs than Galen, thefe defcriptions were only conjedlures, or the confequence of the ftudy of fome Greek authors who have not defcended to us. The Mahometan laws prohibit diffedtions, becaule, in the opinion of the Muffulmans, the foul does not depart from the body at the moment of death : it paffes from one member to another till it cen¬ ters in the bread, where it remains for a coniiderable time. The examination by the angels, of the deceafed per- fon in his tomb, could not be made on a mutilated corpfe. The phyficians of the Arabs dudied, therefore, only fkeletonsdn the cemeteries, and in mod furgical cafes im¬ plicitly followed the ancients. Chemidry, with the red of the fciences, being banilhed from the other parts of the world, alfo took refuge among the Arabs. Geber in the feventh or eighth, and others in the ninth, century of the Chridian asra, wrote feveral chemical, or rather alchymical, books, in Arabic. In thefe works of Geber are contained fuch ufeful directions concerning the manner of conducting didillation, calci¬ nation, fublimation, and other chemical preparations, and fuch pertinent obfervations refpedting various mine¬ rals, as judly feem to entitle him to the character which fome have given him of being the father of chemidry, the difcoverer of the key to the ricked treafures of nature, though he himfelf modedly confelTes that he has done little elfe than abridge the dodtrine of the ancients con¬ cerning the tranfmutation of metals. He mentions fe¬ veral mercurial preparations, fuch as the corrofive fubli- mate and red precipitate, nitric acid, muriatic acid, and many other chemical compofitions. The Herbal of Diol'corides was enriched by the Saracens with the addition of two thoufand plants, and their knowledge of the vegetable world enabled them to infert in their pharmacopoeia feveral remedies which had been unknown to the Greeks. One great difference between the Grecian and Saracen difpenlatories was, that the me¬ dicines in the latter were of a milder nature than thofe in the former: another difference was the common ufeof fugar in lieu of hopey. Diofcorides, fpeaking of the va¬ rious fpecies of honey, fays, that there is a kind of it in a concrete date, called, Jaccliaron, which is found in reeds in India and Arabia Felix : he alfo defcribes its medicinal virtues. Galen writes upon it nearly in the fame man¬ ner; but the hidory of the artificial preparation of fugar, by boiling or other means, was very imperfedtly known. The Saracens appear, however, to have underdood the art ; for, by a mixture of fugar with other ingredients, they made various medicines with which the ancients were unacquainted. The caliphs had done much to render the Arabians thus eminently learned. In the feventh century, Almanfor, and his famous fuccefior Harun A1 Rafchid, patronifed feveral medical fchools, founded hofpitals and academies, and afiiduoufly cultivated the introduction of Grecian learning. Unfortunately, the Arabian phyficians mixed abfurd and myderious fuperftitions with the knowledge they thus acquired. The popular tade for the marvellous induced them to refort to every means of impofing on the vulgar. Adrology was introduced, par¬ ticular pofitions and appearances of the liars were ftudied in dangerous cafes, and amulets were in the poffellion of every fuccefsful and popular pradtifer of medicine. As difcoverers and inventors, the Saracens have few claims to praife, but they formed the link which unites ancient and modern literature; and, fince their relative fituation with Europe fomewhat refembled the relative fituation between Egypt and Greece, they are entitled to a portion of our refpedt and gratitude. When the princes of the wed began to emerge from barbarifin, they cor¬ rectly acknowledged the Moors to be the great depofitaries of knowledge. Many ufeful treatifes, now loll in the original, for example the fifth, fixth, and’ feventh, books of the Conic Sections of Apollonius Pergamus, and fome of the commentaries of Galen and Hippocrates, were pre- ferved in the language of the Saracens, or Arabians, as they are indifferently called. Among the moll eminent of the Arabian phyficians, we may reckon Rhazes, Avicenna, Albucafis, and Avenzoar. Rhazes, one of the olded and mod didinguifhed, was born at Rei, in the province of Chorafan, about the year 852. There was a fchool in his native town, at which he received his early education ; but he is laid not to have commenced the dudy of medicine till fomewhat late in life, having given up his time much to the cultivation of nuific. After he was thirty years of age, he removed to Bagdad ; and then he turned his attention to philofophy, and afterwards to phyfic. He became, however, indefa¬ tigable in his application; and was continually occupied in obferving, reading, and writing, until he obtained the highed reputation ; and he was feledted out of a hundred eminent phyficians, who were then refident at Bagdad, to fuperintend the celebrated hofpital of that city. The hif- torians confidered him as the Galen of the Arabians ; and, from his long life and conftant practice, during which he paid the moll affiduous attention to the varieties of difeafe, he obtained the appellation of the Experimenter, or the experienced. He was faid alfo to be profoundly fkilled in all the fciences, efpecially in philofophy, aftronomy, and rnufic. Fie travelled much in purfuit of knowledge, and made frequent journeys into Periia, his native country, and was much confulted by feveral princes, particularly by Almanfor, the chief of Chorafan, with whom he fre¬ quently correfponded, and to whom he dedicated feveral of his writings. Abi Ofbaia enumerated 226 treatifes compofed by Rhazes, among which the ten books addrelfed to his patron Almanfor are mentioned, and therefore are doubtlefs genuine, although Haly Abbas, who has given an account of him and his works, has not noticed them. This work Rhazes defigned as a complete body of phyfic, and it may be deemed the great magazine of all the Ara¬ bian medicine : the ninth book, indeed, which treats of the cure of difeafes, was in fuch general ellimation for feveral centuries, that it was the text-book of the public fchools, and was commented upon by the moll learned profellbrs. Neverthelefs, like the rell of the Arabian writings, it contains very little more than the lubllance of the wmrks of the Greeks, from whom the Arabians borrowed almoft all their medical knowledge. They have, indeed, and Rhazes in particular, given the firlt diltindl account of the JinalL-pux, a pellilential malady which the Greeks have no¬ where accurately defcribed, and which is, therefore, gene¬ rally inferred to have been unknown among that people. This is quellionable ; but, at all events, the firlt lpecific account of the fmall-pox is to be found in the works of Rhazes. He was the author, alfo, of the firlt treadle ever compofed refpedting the difeafes of children. His book on. the affedtions of the joints is interelling, and contains an account of fome remarkable cures, effected chiefly by co¬ pious blood-letting. He defcribes the fymptoms of hy- 4 drophobia PATHOLOGY. 19 drophobia very well ; and alfo Tome difeafes peculiar to eaftern countries, as the ignis perilous, vena medinenfis, See. and he fil'd noticed the difeafe called fpina ventofa. Rhazes had the reputation of being a ikilful alchemift; the art of chemiftry, in fa£t, originated with the Arabians; and Rhazes is the firft, as Dr. Freind has fliown, who men¬ tions the ufe of chemical preparations in medicine. He has a chapter on the qualifications of a phyfician ; and a Angular trail on quacks and impoftors, in which he has pourtrayed that claft of pretenders to the life ; and his detail of their pretenfions (flows that they were at leaft as numerous, and ingenious in their contrivances of cheatery, as in more recent times. Rhazes lived to the age of eighty, and loft his fight : he died in the year 932. His works that have come down to us, through the me¬ dium of tranflations in Latin, are, 1. A fort of common¬ place book, entitled Continent, or Libri Continent es. a. A much more perfect work, the Libri Decern, ad ' Alnutnf or em, publifhed at Venice, 1510. 3. Six books of Aphorifms, publiflied under the title of Liber de Secretis, gui Aphorif- morum appellatur, Bononiae, 1489. 4. A trail on the fmall-pox and meafles, entitled, De Pejlilentia. This laft was tranflated by Dr. Mead in 1747, and by Mr. Chan- ning in 17 66. As it is a fubjeil fo much in difpute, we (flail give an extrail from the very firft chapter. “ As to thofe phyficians who affirm, that the mod excellent Galen lias made no mention of the fmall-pox, and therefore that lie did not know this diftemper ; furely they have either never read his works at all, or only very curforily; nay, ,moft of them do not know, whether what he plainly fays of it is to be underftood of that difeafe. For Galen, in a certain treatife, fays, this drug does good this and that way, and alfo againft the fmall-pox. And in the beginning of the fourteenth book, of pulfes, that the blood is putre¬ fied in an extraordinary degree, and that the inflammation runs fo high, that it burns the fkin ; fo that the fmall-pox and peftilent carbuncle are bred in it, and quiteconfume it. And in the ninth treatife of the book of the Ufe of the Parts, he obferves, that the fuperfluous parts of ali¬ ments, which are not turned into blood, and remain in the members, putrefy, and in time increafing do ferment; whence, at laft, are generated the peftilential carbuncle, the fmall-pox, and confluent inflammations. Laftly, in the fourth part of his Commentary upon the Timteus of Plato, he fays, that the ancients gave the name cp\iyp.otrt to every thing which produces rednefs,as the carbuncle and fmall- pox ; and that thefe difeafes are bred in thofe in whom bile abounds. But, as for thofe who allege; that he has propofed no remedy or cure, nor explained the nature of this diftemper, they indeed fay what is true : for he men¬ tions no more than what we have cited. But God knows whether he might not have done it in fome other books, which have not yet appeared in Arabic.” Avicenna’s Canon Medicines, or General Syftem of Me¬ dicine and Surgery, was for many ages celebrated through all the fchools of phyfic. It was principally compiled from the writings of Galen and Rhazes. The latter had, in difficult labours, recommended the fillet to aflift in the extrafilion of the foetus 5 and, for the fame purpofe, Avicenna recommends the forceps. He deferibes the compofition of feveral cofmetics to polifh the fkin, and make the hair growq or fall off. See the article Avi¬ cenna, vol. ii. Albucafis flourifhed about a hundred years after Avi¬ cenna : the date of his birth is not known, but he died in 1106. He is chiefly eminent as a furgeon ; and, al¬ though much of what he has left on the fubjedt of his art is copied from Rhazes, from Paulus -Eginasta, and other preceding writers; he has many original obferva- tions ; and by thofe who love to fee the firft dawnings of improvement in fcience, his works will be dill turned over with pleafure. He infilled on the neceflity of a fur- geon’s being fkilled in anatomy, to enable him to ope¬ rate with fuccefs; he alfo held it to be equally neceflary that he fhould be acquainted with the materia medica, or the properties of the medicines employed in curing dif¬ eafes ; and inveighs againft thofe who undertake for gain the cure of difeafes, of the nature and caufes of which they are unacquainted. It appears from his writings, that he extracted polypi from the noftrils, performed the operation of bronchotomy, and ufed a preparation fimilar to the lapis infernalis, as a cauftic. He enumerates a tremendous lift of operations, fufficient to fill us with horror. The hot iron and cauteries v.'ere favourite re¬ medies of the Arabians ; and, in inveterate pains, they repofed, like the F.gyptians and eaftern Aliatics, great confidence in burning the part. He deferibes accurately the manner of tapping in afeites; mentions feveral kinds of jnllrunients for drawing blood ; and has left a more ample and corredl delineation of lurgical inftruments than any of the ancients. He gives various obftetrical direc¬ tions for extrafling the feetus in cafes of difficult labour. He mentions the bronchocele, or prominent tumour on the neck, which, he tells us, was mofl frequent among the female fex. We are alfo informed by this writer, that the delicacy of the Arabian women did noUpermit male furgeons to perform lithotomy on females 5 but, when neceflary, it was executed by one of their own fex. Of Avenzoar nearly all that is known has been com¬ municated under his article. The date of his birth is uncertain ; he is faid to have lived to the great age of 135 years ; but, as he had a fon of the fame name and pro- feflion, it is very probable that the age of both is in¬ cluded in this term. He (or his fon) died at flforocco in 1166, or at Seville in 1162. Avenzoar prepared his own medicines, reduced luxated bones, and performed other chirurgical operations. The work by; which he is principally known is a compendium of the praflice of medicine; in which fome difeafes are deferibed not found in other writers. It includes a number of cafes, candidly, it fhould feem, related, as the author does not conceal thofe in which he was unfuccefsful. See Avenzoar, vol. ii. Thus we fee, that, in confequence of the general decay of learning in the weftern parts of the w'orld, the Greek writers were entirely neglefled, becaufe nobody could read the language ; and the Arabians, though principally copiers from them, enjoyed all the reputation that was due to the others. The Arabian phyfic was introduced into Europe very early, with the mofl extravagant ap- plaufe : and not only this, but other branches of their learning, came into repute in the weft ; infomuch that in the nth century, theftudies of natural philofophy and the liberal arts were called “ the fludies of the Saracens.” This was owing partly to the crufades undertaken againft them by the European princes ; and partly to the lettle- ment of the Moors in Spain, and the intercourfe they and other Arabians had with the Italians. For, long be¬ fore the time of the crufades, probably in the middle of the 7th century, there were Hebrew, Arabic, and Latin, profeffors of phyfic fettled in Italy and Spain. The uni- verfity of Cordova, which had been founded by Alhakem, became the molt celebrated in the world, and maintained its repute for a long courfe of years. As early as the tenth century, Cordova could boaft of the largeft library in the weft; a library of 250, ooo'books, and of which the catalogue is faid to have filled forty-four volumes. In the twelfth century, there were no lefs than feventy public libraries in Spain : Cordova had produced 1 50 authors, Almeria 52, and Murcia 62. At Seville, at Toledo, and at Murcia, academies were alfo eftablifhed, which continued to flourifh during the whole period of the dominion of the Arabians. In the tenth century, the rich and maritime city of Salerno, in the Neapolitan territory, arrefted the attention of the predatory Muflulmen. Frequently engaged either in war or in negociation, they became mixed with the Chriftians, and gradually communicated their literary attainments ; and, in the year 802, Charlemagne founded in Salerno a fchool, which in procefs of time^ became the moll 20 PATHOLOGY. mod celebrated in the world. About the latter end of the nth century, Conftantine the African introduced into the Salernian fchooi the Grecian authors, as well as the learning which he had obtained from a long refidence in Babylon and Bagdad. In the twelfth century, how¬ ever, this fchooi arrived at its higheft fame; and was much frequented by the crufaders in their paftage to and from the Holy Land. Among thefe, Robert, the ion of William the Conqueror, had the honour of having the well-known “ Regimen Sanitatis Salerni” dedicated to him. In the year 1140, the emperor Frederic II. con¬ ferred particular privileges on the fchooi of Salerno, and regulated the courfe of ltudies, and the probations which phyficians and furgeons ihculd undergo before they were permitted to praftife. Many of the ordinances iliow great judgment. The Salernian fchooi continued accordingly to flouriih till the middle of the fourteenth century, when it appears to have begun to decline. “Fuiffe Salerni,” fays Petrarch, “medicinas fontem fama eft ; fed nihil eft, quod non fenio exarefcat.” Gariopontus, Nicolaus, AEgidiu-s, Enos, and John of Milan, the author of the Regimen Sanitatis, are the chief writers whom this fchooi boafts. This fchooi was perhaps, the firft that eftabliftied the form of public examination and admiftion, and pof- fefled the power of conferring medical licenfes and de¬ grees. It recognifes molt obvioufiy the exiftence of apo¬ thecaries, and enforces the propriety of difcriminating the three branches of the medical profeflion from each other. The phyfician was under the neceftity of pro¬ ducing teftimonials that he had been a medical ftudent for feven full years ; the furgeon that he had attended to anatomy for at leaft one ; and the apothecary was pro¬ hibited from charging more than an eftabliftied ratio for the medicaments he compounded or employed. While the eaftern nations aftiduoufty cultivated the knowledge of the Greek writers, and while their caliphs and rulers encouraged fcience by a liberal patronage, a very different part was followed by the Chriftians. The clergy, actuated by avaricious motives, feized upon the province of the phyfician ; and the moft ignorant priefts and rn.onks ventured upon the practice of medicine, with¬ out any proper ftudy or preparation. At length the evil became too crying to be any longer endured ; and the firft Lateral! council, held in 1123, forbade the regular clergy to vifit any longer the lick. The prohibition was re¬ peated, in other terms, by the council of Rheims in 1131, and by the fecond general Lateran council in 1139 ; and thofe monks and canons who applied themfelves to phy¬ fic, “ordinis fui propofitum nullatenus attendentes, pro de- teftunda peeunia fmitalem pollicentes ,” were threatened with fevere penalties ; and all bifhops, abbots, and priors, who connived at their mifconduft, were ordered to be fuf- pended from their ecclefiaftical funftions. “ But the French priefts and monks,” fays Cabanis, “bade defiance to thefe thundering anathemas ; and it was not till three hundred years after, that common fenfe, and a regard to propriety and the public good, triumphed finally over their artifices. A fpecial bull, procured by the cardinal d’Eftonteville, in 145a, which permitted phyficians to marry, effected their complete feparation from the clergy ; and, l this means alone, put a flop to a variety of fliame- ful abufes. To the honour of our country, however, be it men¬ tioned, that thefe abufes do not appear to have prevailed to fuch an extent among us. The clergy did not indeed praftife phyfic, but they were armed with great autho¬ rity over thofe who did. In the days when benefit of clergy had a laving fignification in courts of law, the minifters of religion were regarded with great reverence; and their powers over the practice of medicine are not yet quite extinft. The firft control exercifed over the practice of phyfic in England appears to have been ecclefiaftical, though the end and purpofe of the interference of the church on this occafion, as in moft others in thofe times, .as not fo much the health of the body as the welfare of the foul, ecclefiaJUcaUy underflood. One of the confti- tutions of Richard Wetherfhed, archbilhop of Canterbury anno 1229, in the fourteenth year of the reign of Henry III. runs as follows : “Under pain of anathema, we for¬ bid any phyfician to give advice for the health of the body which may prove perilous to the foul, which is much more precious than the body. But, when it happens that he is called to a lick man, let him firft effeftually perfuade him to call for the phyfician of the foul ; that, when the fick man has taken fpiritual cure, he may, with better effeft, proceed to the bodily medicines. Let not the tranfgreftors of this conftitution efcape the punilhment appointed by the council.” The punilhment here de¬ nounced againft phyficians fo offending, was a prohibi¬ tion from entrance into the church till they had made fatisfaftion, according to chap. xxii. of the council of Lateran, under Pope Innocent III. from whence this conftitution is taken. It was nearly two centuries after this, namely, in the reign of Henry V. anno 9. that the firft ftatute was enafted relative to praftitioners in phyfic. The preamble to this aft, after reciting the mifchiefs arifing from illiterate praftifers, ftates, “ that if no man praftifed therein but all only conynge men, and approved, fufficiently ylearned in art, filofofye, and fifyk, as it is kept in other londes and roiaumes, therftiuld many man that dyeth for de- faute of help lyve, and no man perilh of unconnyng.” The petition then goes on to pray, that no perfon be allowed to praftice phyfic, “ but he have long time yufed the fcoles of fifyk within fome univerfitee, and be gra¬ duated in the fame.” The next aft reftraining the praftice of phyfic in London and its immediate vicinity, to perfons of approved competency, was palled in the third year of the reign of Henry VIII. feven years prior to the eftablilhment, by charter, of the prefent College of Phyficians. Its title was, “ An Aft for the appointing of Phyficians and Sur¬ geons.” It was enafted that no perfon within the city of London, nor within feven miles of the fame, take upon him to exercileand occupy as a phyfician or furgeon, except he be firft examined, approved, and admitted, by the bilhop of London, or by the dean of Paul’s, for the time being, calling to him or them four doftors of phyfic, and, for furgery, other expert perfons in that faculty. When the Charter of the College of Phyficians was granted by the king, it was on the petition of a prieft, the cardinal Wolfey, chancellor of England, in conjunftion with John Chambre, Thomas Linacre, Ferdinand de Victoria, foreign graduates, the king’s phyficians, and Nicholas Halfwell, John Francis, and Robert Yaxley, phyficians. And the archbilhop of Canterbury can, and does to this day, by his diploma, conftitutea phyfician. To return from this digrelfion. — After Salernum, the Univerfities of Montpellier, Paris, Boulogne, Pavia, Padua, and Ferrara, became the moft diftinguilhed femi- naries for medical education ; but the fervile attachment to ancient dogmas which obtained in their fchools ma¬ terially retarded their progrefs. In 1271, the College of Surgeons at Paris was eftabliftied by Pitard, a man who, according to Quefnay, was born for the advancement of his art ; and furgery was henceforth cultivated with much fuccefs in France, as a diftinft branch of the profeflion. Several writers on phyfic appeared in England ; among whom Gilbert has the merit of having furnilhed the belt defcription of the leprofy of the middle ages ; but he trod in the footfteps of the Arabians, and gave into the fcho- laftic ftyle. The fame remark applies to his fucceftors, John of St. Giles, Richard of Windermere, Nicolas of Farneham, John of Gaddefden, &c. It was in Italy that medical fcience was revived in the trueft fpirit. In the year 1315, Mondini de Luzzi, profeffor at Bologna, aftoniflied the whole world, to ufe vicq d’Azyr’s expref- fion, by the public difleftion of two human bodies. His example was followed in other univerfities ; but the utility of the praftice was in a great degree fruftrated by PATH the predilettion for ancient opinions, which made the anatomifts of the age lefs anxious to difcover new fatts, than to reconcile the appearances which they obferved with the dogmas of Galen and Avicenna. An abfurd bull of pope Boniface VIII. forbidding the maceration and preparation of Ikeletons, alfo concurred to impede the progrefs of anatomy; (Blumenbach, Hift. Med. Litterar. p. 99.) but from this time forward, the Italian profeffors maintained a high repute for anatomical fcience, and have ranked among the inoft zealous contributors to our knowledge of the human frame. Though the crufades had conferred no direct benefits on fcience, they had given a new impulfe to the human mind, by the fpirit of commerce which they excited. They were alfo the occafion of the rapid fpreading of leprofy and fome other difeafes in the Weft, and of the confequent increafe of inftitutions for the relief of the fick, after the example of the Oriental nations. Several orders of knighthood, as the Templars, the knights of St. John, of St. Lazarus, the Hofpitalarii Santti Spiritus, &c. were founded with this charitable view ; the mem¬ bers devoting themfeives to the cure of fuch pilgrims as were afflitted with difeafe. In the fifteenth century feveral new difeafes appear to have invaded mankind, or, at leaft, to have attacked them with a degree of violence that was before unknown. The whooping-cough was epidemic in France in the year 14.14: and, according to Mezeray, it attacked all defcrip- tions of perfons, even, the oldeft men. The fweating ficknefs, which broke out firft in the fame country, was brought to England by the foldiers of the duke of Rich¬ mond (afterwards king Henry VII.) upon his landing at Milford-haven in 1485; and fpread itfelf at London from the 21ft of September to the end of Ottober. It returned there five times, and always in fummer; firft in 14 95, then in 1506, afterwards in 1517, when it was fo violent that it killed many in the fpace of three hours, fo that numbers of the nobility died, and of the com¬ monalty in feveral towns often the one-half perilhed. It appeared the fourth time in 1528, and then proved mortal in fix hours ; many of the courtiers died of it, and Henry VIII, himfelf was in danger. In 1529, and only then, it infefted the Netherlands and Germany, in which laft country it did much mifchief. The laft return of it was in 1551 ; and in Weftrninfter it carried off 120 in a day. At this time alfo a new difeafe overran the world, and threatened greater deftruttion than almoft all the old ones put together, both by the violence of its fymptcms,and its baffling the moft powerful remedies at that time known. This was the venereal difeafe, which is fuppofed to have been imported from the Weft Indies by the companions of Chriftopher Columbus. Its firft remarkable appear¬ ance was at the fiege of Naples in 1494, from whence it was foon after propagated through Europe, Afia, and Africa. The fymptoms with which it made the attack at that time were exceedingly violent, much more fo than they are at prefent ; and confequently were utterly un¬ conquerable by the Galenifts. At this period, as fea- voyages of confiderable duration were more frequent, the fcurvy became a more common diftemper, and was of courfe more accurately defcribed. But probably, from 1'uppofed analogy to the contagions which at that time were new in Europe, very erroneous ideas were enter¬ tained with regard to its being of an infettious natures and it is not impoflible, that, from* its being attended alfo with ulcers, it was on fome occafions confounded with fyphilitic complaints. Dreadful as the inflittion of thefe maladies muft have been on the fuffering world, we have reafon to believe that they were not without their ufe in leading to the improvement of medicine. The phyficians of the time, finding the rules of their favourite authors quite inap¬ plicable to the cure of diftempers fo malignant, naturally began to obfefve and judge for themfeives. Manardi and Leoniceno (fee their refpedlive articles) laboured to Vol. XIX. No. 1284. O L O G Y. 21 expofe the errors of the Arabs, and bring back, their followers to the ftudy of Nature and Hippocrates. In this laudable undertaking they were feconded by the German, French, and Englilh, profeffors ; and particu¬ larly by the labours of Dodoneus, Schenkius, Foreftus, and Platerus. In the early part of the fixteenth century, Briffot of Poitou revived a fubjett which had before engaged phy¬ ficians in violent difputes. According to the Hippocratic mode of treating inflammation, which was to take* the blood from the inflamed part as clofely as poflible, the Greek phyficians were wont, in pleurify, to bleed in the arm of die fame fide as was affetted with pain. Avicenna had objetted to this, and recommended venefettion in the oppofite arm. This produced a great deal of alter¬ cation ; and in the end a decree of the univerfity of Palermo iffued forth which forbade any one to bleed ex¬ cept in the contrary arm ; and the profeffors endeavoured to perfuade the emperor Charles V. to fecond it by an edidt. Briffot met with almoft as much opposition in reviving the old method as the Salernitans had done in introducing the new one : but at length the difpute was fettled in favour of Briffot by the great anatomical dif- coverers of that century. The fcience of anatomy gradually became imnroved in the hands of Zerbi, Winter, Laguna, and Sylvius ; which laft taught anatomy at Paris in 1532. But it was referved for the great and comprehenfive mind of Vefalius to throw off the fhackles which had fo long fettered the progrefs of anatomy. So far from adopting as infallible dogmas the anatomical relations of Galen, he attached himfelf particularly to difclofing the errors of that author. He firft advifed anatomifts to injett co¬ loured fluids into the veffels of the body, in order to fa¬ cilitate the labour of minutely tracing them. Wliilft he was a young man at college, he purfued anatomical in¬ quiries with great ardour and afliduity, and publilhed fome of his difcoveries before he was twenty-five years of age, and feven books on the anatomy of the human body before he was twenty-nine, A. D. 1542. Thefe books contain great difcoveries, and, in many circumftances, correct the ancients. But, although they have entitled their author to the gratitude of pofterity, they procured to him fcarcely any thing but animofity from his con¬ temporaries. The authority of Galen was ftill held in high veneration ; and, when Vefalius expofed his errors, the hatred of all feemed turned againft him. People could not bear to be fet right by fo young a man; and even Sylvius denounced perpetual enmity againft him. But, confident in the certainty with which diffettion furninied him, he acquired a complete afcendancy over liis adver¬ saries : fo much fo, indeed, that his lettures were fome- tiines attended by 500 pupils. He preffed Sylvius, his mafter, fo hard, in. thefe controverfies, that the latter, rather than admit his favourite Galen was wrong, afferted* that “ the Jtrudiure of the human body hud become altered in fomeparticularsjin.ee the time of Galen, and. that man’s nature had degenerated !” Thus, for inftance, the number of the pettoral bones occafioneda difpute, which was carried on with great acrimony between them. Galen had adopted feven in the human ikeleton ; but Vefalius proved that there were only three, and that his opponent had again been milled by the Ikeleton of a monkey. But Sylvius objetted to this, “ that men had been larger and taller in the time of Galen, and had feven pettoral bones, but that, in this dwarfilh century, three only could be found.” Vefalius afferted, that the bones of the hand are not totally deftitute of medullary fubftance, as Galen had maintained ; and Sylvius again endeavoured to re¬ fute his affertion, by the abfurd argument, “that the bones in former times had been firmer and harder, and confequently required no fuch fubftance.” Vefalius re¬ jetted the large curvature which Galen aferibed to the os humeri, and the os ilium; while Sylvius defended Galen, by afferting, that the bones had become more G ftraight 22 PATHOLOGY. ftraight by the modern mode of drefs. He vindicated, in a fimilar manner, Galen’s neglect in defcribing the car¬ tilages of the extremities of the bones: ‘'In former times,” faid he, “ the bones were more folid, and confe- quently required no cartilages !” Thefe prejudices had not paffed away from among the French phyficians even in the following century; for we find Moliere, in his Medecin malgri lid (Mock DoCtor), alluding to the abfurdity we have juft mentioned, of fome parts of the vifcera having changed their places. “ Dodlor. Now thefe vapours of which I am fpeaking having palled from the left fide, which is the feat of the liver, to the right, where the heart is fituated, then the Jungs, which we call in Latin armyan, communicating with the brain, which in Greek we call nafrnus , by means of the vena cava, which is cubile in Hebrew, meets in its way with thefe vapours, which fill the ventricles of the omoplate ; and, fince thefe vapours pofiefs a certain ma¬ lignity caufed by the acridity of the humours engendered in the concavity of the diaphragm, it therefore happens that thefe vapours — in fiiort, this is precifely the reafon why your daughter is dumb. “ Father. Nothing in the world can be clearer than this reafoning. Only one difficulty occurs to me ; namely the feat of the liver and of the heart. I always thought the heart to have been on the left fide, and the liver on the right. e‘ Doflar. Yes ; it was fo formerly ; but we have altered all that, and medicine is now adminijiered in a manner to¬ tally new." Mock Doftor, aft ii. Vefalius had great advantages over his predeceffors in being able to perpetuate his labours by means of the beautiful reprefentations which Titian and others painted for him. In 1561, Fallopius, in Italy, publifhed his Ob- fervationes Anatomicte ; he was an indefatigable anato- mift, and made great difcoveries. About the fame time, Euftachius made himfelf confpicuoufly eminent by pro¬ moting anatomical knowledge. He feemed calculated for fubtle inveftigations ; he drew many figures of the human body, and engraved his own plates, the accuracy of which cannot fail of exciting furprife in an anatomift of the prefent day. When the labours of thefe eminent men had, as it were, fmoothed the path, anatomy was taught with a moderate degree of correCinefs and mi- mitenefs in the different fchools of Europe. But the moft important difcovery of this fcience was that of the circulation of the blood. Berengar, who had paid great attention to the ftruCfure of the heart, conjeffured the right ufe of the femilunar valves. In 1547, Cannani and Amatus obferved the valve at the ter¬ mination of the vena azygos; but they did not turn the difcovery to account; and it was referved for Fabricius of Aquapendente to prove the prefence of valves throughout the whole courfe of the veins. Five years afterwards, the circulation of the blood through the lungs was imperfeCHy defcribed by Servetus, who had availed himfelf of the refearches of Berengar and Vefalius. In the year 157-1, Csefalpinus had the merit of ftating it more clearly, and even of fuggefting the firft hint of the greater circulation ; but the full honour of the latter difcovery muft be afcribed to our countryman, Harvey. This improvement in anatomical knowledge was ne- ceffarily accompanied by a ccrrefponding one in forgery. The Italian furgeon, Maggi, corre&ed the abfurd no¬ tions that his predeceffors had inculcated, viz. that gun- fhot wounds were conneCled with combuftion, and that gunpowder poifoned the wound. He fhowed that, fince the balls did not fet the wadding on fire when they came firft from, the barrel of the gun, they could not be hot; nor could gunpowder poifon a wound, fince it was com- pofed of none but harmlefs materials. Maggi likewife left fome ufefnl directions concerning amputation. Am- brofe Pare introduced into France the treatment of gun- fliot wounds eftablifhed by Maggi. The fame praCfice v.as likewife adopted by John Baptift. Carcano Leone, profeffor at Pavia. Pare was, however, unqueftionably the moft celebrated furgeon of the 3 6th century. Be- fides the improved treatment of gun-fhot wounds, which he had the merit of introducing, together with many other peculiarmethods in operative furgery, he has ren¬ dered effential fervice to different branches of that fcience. He treated, for inftance, the hydrocele withafeton; as the dangerous confequences of incifion were in that age more frequently obferved than they are at prefent. He did not apply the aCtual cautery to wounded blood-vel- fels, according to the old practice, but fecured them by the ligature. The fraCture of the collum offis femoris, formerly confidered as a luxation of that bone, was firft afcertained by him wfith accuracy ; he alfo reprobated the frequent dreffmg of ulcers, and the application of the trepan to the futures of the cranium and the temporal bones. He made very judicious remarks on concuflions of the brain, of which Henry II. died, and on fuppura- tions of the liver arifing from injuries of the head. Wounds of the throat, in which one of the jugular veins, and even the trachea, was cut through, he did not confideras mortal. He fuccefsfully treated an injury of the nervus medianus from venefeCtion, and thereby ac¬ quired theconfidence of Charles IX. who had been fubjeCt to that dangerous accident. A perfon who, from lofing a great part of his tongue, had been fpeechlefs for a con- fiderable time, accidentally recovered the power of fpaech, by thruftiiig a table-fpoon into his mouth. Pare ingeni- oufiy imitated this method, by contriving an appropriate inftrument. Amatus, or, according to fome, his mafter Aldaretti, had invented the ufe of bougies; and thofe inftruments now catne into very general ufe, both flmple and caufti- cated. The doCirine of lithotomy was confiderably improved in this century, by the invention of two different me¬ thods of operating, namely, the great and the high opera¬ tion. Germain Colot had undertaken a fuccefsful opera¬ tion for the ftone, in the fifteenth century, and proba¬ bly by the high operation : but it does not appear that learned furgcons had imitated this method, till an obfcure praCiitioner at Cremona, John de Romani, in 1525, be¬ gan to adopt what is commonly called the high opera¬ tion : he taught it to Mariano Santo de Berletta, a lur- geon at Naples, who defcribed the particulars of it in a feparate treatife, publifhed at Venice in 3543, wherein he profefies to have been a pupil of Romani. It is probable that previous to this time no other method of operating was praCtifed than that known under the name of the J mailer apparatus, which can be employed only on children under fourteen years of age. In fome rare inftances which are related by Benivieni and Chrift. de Vega, par¬ ticularly in women, the ftone had been found in the ure¬ thra itlelf, in which cafes it could be more eafily ex¬ tracted. But, fince that period, the pafifage was cleared by the application of the gorget, by means of which the forceps could be introduced into the bladder. Mariano Santo made ufe of the following apparatus:' he firft em¬ ployed a curved found, which he introduced into the urethra fo as to direct the point to the left fide ; he ex- prefsly cautioned the operator againft the incifion into the perinaeum, and is therefore unjuftly cenfured for hav¬ ing attempted the incifion in the middle. His found was excavated, and he performed the incifion in the direction of the groove; then introduced the found, and along with it the conductors, and afterwards the gorget, which, ac¬ cording to its original conftruCtion, terminated in a blunt point; and laftly, he extracted the ftone with the forceps, and removed the remaining particles of it, as well as the gravel or fand, by means of the litbotomical fpoon. By the application of the blunt dilator, the parts were ne- ceffarily lacerated, and the wound occafioned by this la¬ ceration could not be healed without great difficulty. Hence Le Dran endeavoured to improve upon this me¬ thod, efpecially by making an incifion through the prof- tate 23 PATHOLOGY. fate gland and the bladder with his guarded knife ( cou- teuu en rondaclie); and the immortal Schmucker of Ber¬ lin was uncommonly fuccefsful in ufing the great appa¬ ratus for lithotomy in that improved ftate. The difcovery of the high operation was the work of necefiity and accident. Peter Franco, of Turrieres in Provence, furgeon at Berne, Laufanne, and Orange, was requefted in the year 1560 to perform this operation for lithotomy, at Laufanne, on a child two years of age. He had already begun to operate with the fmall apparatus, when he found that the Hone was of the fize of a hen’s egg, and confequently too large to be removed in that manner. The child’s parents infilled that the operation Ihould neverthelefs be finilhed; and, as the bladder very much projefted above the ofla pubis, he determined upon making the incifion above thefe bones. Although he eventually fucceeded in this bold attempt, yet he pru¬ dently diffuades his brethren from imitating that practice; and indeed the danger to be apprehended from the effu- fion of the urine into the abdomen is fo great, that even the improvements made by Douglas, on the high appa¬ ratus of Franco, have not much diminilhed it. In order to remove the lione from female patients, Franco rejefts both the large and fmaller apparatus, while he propofes merely the dilatation of the urethra, by means of an in- ilrument invented by himfelf; after which he extracts the Hone with the forceps, without difiefting the parts. He likewife invented a gorgeret, and a forceps, the arms of which expand in the bladder; but the ufe of thefe inftraments has been fuperfeded by others that are more convenient. A very painful but curious operation excited great at¬ tention during this century, although it had been pre- vioufly performed. The reader will perhaps fmile at an attempt to repair and reftore that prominent part of the human face, the nofe, when mutilated by accident. Barri, an Italian author, in his “ Italia illuftrata,” 1600, ccmfiders Vincent Vianeo as the inventor of this lingular pra&ice. However that may be, two Sicilian furgeons of the name of Branca, father and fon, had, fo early as the latter end of the fifteenth century, acquired celebrity by the fuccefsful renovation of nofes; an art which be¬ came hereditary in the family of the Bojani. But Caf- par Tagliacozzi, profefl'or at Bologna, railed this art to fuch high perfe&ion, as to render it one of the principal branches of furgery : he became fo celebrated by his ope¬ rations, that his contemporaries erefted a public monu¬ ment at Bologna, where he is reprefented with a nofe in his hand. This operation is defcribed in an interefting work, intitled, “ Tagliacot. de Curtor Chirurg.” fol. Venet. 1597 ; in which he compares it to the ingrafting of trees, expatiates on the dignity and ornament of the nofe, and endeavours to prove that there is not the leaf! danger in cutting out a piece from the biceps mufcle of the arm. With refpeft to the diet to be obferved during the ope¬ ration, he gives ample and rigid inftrudlions, while he maintains that the inoculated nofe is poflefled of a more acute fra ell, and that it generally grows much larger and ftrcmger than the organ which had been accidentally loft. We may fuppofe that this operation became lefs fuccefs¬ ful in the hands of other furgeons, and fo fell into difufe and contempt, as we find it ridiculed by Butler in the s 7th century : So learned Taliacotius from The brawny part of porter’s bum Cut fupplemental nofes, which Would laft as long as parent-breech; And, when the date of that vras out, Off dropt the fympathetic fnout. Hudibras, Canto i. It has, however, been revived in the prefent day ; and has been praftifed with great fuccefs by Mr. Carpue, Mr. Linn, and others. We might here mention the names of other practitioners who improved and illuftrated the ufeful art of furgery : as John de Vigo, Jacob Berenger de Carpi, and Mariano Santo de Berletta ; tile latter of whom abolifhed the aftual cau¬ tery in haemorrhages, and urged the fuperiority of a pro¬ per ligature. The anatomift Fallopius, likewife culti¬ vated furgery with fuccefs, as did moft of the anatomifts of his age; and among them we might enumerate many who have contributed important improvements, would our limits permit. The obftetric art, that important branch of furgery, began to emerge from its barbarity during the fixteenth century, and to excite the attention of furgeons more than it had hitherto done. There appeared feveral in¬ troductions to midwifery, the greater number of which, however, contained much ufelefs and abftrufe reafoning on the generation of man, and the vitality of the em¬ bryo in certain months, while they were extremely defi¬ cient in well founded and practical rules for facilitating delivery. See the article Parturition in the preceding volume. The military furgeons of ancient times are very little mentioned in hiftory. Perhaps they were not in very great eftimation 3 as feems probable from the perfons with whom they are claffed in the military code made at Mans by Henry V. where, under the head of the perfons fubjeCt to the conftable and marfiial, the mediei are intro¬ duced in the following company : “ Whether foldiers, flioemakers, taylors, barbers, phyficians, or ■wajher-wo- men.” See Upton de Re Militari. The low ftate of military furgery in France, even fo late as the time of Francis I. (contemporary with our Henry VIII.) may be gathered from the following extraft from an old and fcarce book called TreuJ'ure of Ancient and Modern Times : “In the year of our Lord 1536, the vic¬ torious king Fraunces fent a great army into Piedmont to vitaile Thurin, &c. I was at that time but a young chirurgion, and but little experienced in the art, becaufe I never had as yet feen the curation of wounds made by gun-fhot. True it is, I had read John de Vigo, his firfte booke of wounds in general!, chap. 8. where he faith, that thofe wounds made by fiery engines do participate of venenofity, becaufe of the powder 5 and for their cura¬ tion he commands to cauterize them with the oile of elders, mixed with a little treacle. Yet nevertheleffe, becaufe I would not be deceived, before I made ufe of the faid boyiing oile, knowing that it brought extreme paine to the patient, I obferved the method of other chi- rurgeons in the firft drefiinge of fuch wounds, which was by the application and infufion of the aforefaid oile, as hot as poflibly they could fuffer it, with tents and fetons ; wherefore I became emboldened to do as they did. But in the end ray oile failed me, fo that I was conftrained to ufe, inftead thereof, a digeftive made of the yolk of an egge, oil of rofes, and terebinth. The night following I could hardly deep at mine eafe, fearing left that, for want of cauterizing, I ftiould find my patients, on whom I had not ufed the aforefaid oile, dead and em- poyfoned; which made me rife early in the morning to vifit them, where, beyond my expectation, I found them on whom I had ufed the digeftive medicine, to feele but little paine, and their wounds without inflammation or tumour, having refted well all that night; the reft, on whom the aforefaid oile was applied, I found them incli¬ ning to feavers, with greate paine, tumour, and inflam¬ mation, about their wounds ; then I refolved with my- felfe, never to burne fo cruelly the wounded patients by gun-fliot any more. A famous chirurgion at Turin, propofed a balm for gun-lhot wounds as follows: Two young whelps, one pound of earth-worms, two pounds of the oil of lilies, fix ounces of the terebinth of Venice, and one ounce of aqua vitae. In my prefence he boiled the w'helps alive in the faid oile, untill the flelh deferted from the bones afterwards he took the worms, having before killed and purified them in white wine, to purge themfelves of the earth which they have always in their bodies ; being fo prepared, he boiled them alfo in the 3 24 PATHOLOGY, faid oil, till they became dry; this he ftrained thorow a napkin without any great expreffion ; that doone, hee added thereto the terebinth ; and laftly the aqua vita; ; and called God to witneffe that this was his balme, which he ufed in all wounds made by gun-lhoot, and in others which required fuppuration; withall praying me not to divulge his fecret.” How terrible muft have been the ftate of the military hofpitals, and what numbers of men muft have fallen a facrifice to ignorance, who under proper management might have been recovered to the fervice of their country! But, bad as the furgeons were, fome were neverthelefs necefiary in curarmies; and, although thegeneral modeof railing and paying them is not handed down, certainly fome regular form of doing it muft have exifted. In the wardrobe-account of the pay of the army raifed againft the Scots, byHenryll. in the 15th yearof his reign, many of the Wellh corps have an officer ftyled Medicus ; but whether by that term a phylician or furgeon is meant, feems doubtful, as the word medicus is foinetimes ufed for both a furgeon and an apothecary. None of thefe phyficians or furgeons are charged to the Englifii levies. And to the Welch they feem to bear no regular propor¬ tion to the number of private men; a corps of 1907 men having only one, and another of 968 having two ; the wages of all, except the two laft-named, was 6d. per diem each ; thofe which were raifed on the king’s land in Cardiganfhire had only 4d. each per diem. In the lift of the troops that attended Edward III. to the liege of Calais, only one furgeon is mentioned, who feems to have been part of the retinue of the prince of Wales; and, in the military eftablilhment of the 18th df. the faid reign, as given in the accounts of Walter Wentwayt, treafurer of the houfehold, there is one fur¬ geon for the king’s houfehold-troops ; four dodlors and one furgeon. for the army of North Wales; two doftors and one furgeon for that of South Wales ; a fupply by no means competent to the number of men to which they were appointed. Suppolingthe inferior furgeons to have been ftyled barbers, like the field-lhaver of the Germans, it feems reafonable to expefl they would fomewhere ap¬ pear on the mufter-roll. Henry V. A. D. 14.15, engaged Mailer Nicholas Colnet, a phylician, to ferve him for one whole year, in the voyage then to be made either to the duchy of Guyenne or France. Colnet was to bring wdth him three archers. If the expedition went to Guyenne, he was to have for his own wages forty marks, and twenty marks for each of his archers, for the whole year. If to France, for his own wages is. and to each of his archers 6d. a day, with regards. In the fame year the king engaged Thomas de Moreftede, a furgeon, who contradled to bring with him twelve other furgeons and three archers. Moreftede was to be paid as a man at arms, iad. by the day; and his- twelve alfiftants and three archers, each 6d. with the ufual regard. The fame con¬ ditions were covenanted, in cafe the campaign lay in Guyenne, that were made with Colnet. Upon a peti¬ tion, the king granted Moreftede one waggon and two fumpter-horfes, for the carriage cf the baggage and ne- ceffaries for himfelf and the twelve other furgeons. He likewife petitioned for money to buy necelfaries for his office, but it was not granted. The next year the king employed Moreftede, joining with him William Brede- wardyn, with the title of his furgeons, in a ccmmilfion to imprefs as many furgeons as they thought necefiary for the expedition, with a fulficient number of artificers for making their inftruments, to be taken wherever they could be found. Among the different perfons who indented in the 14th of Edward IV. to ferve that king in Normandy and France, for one year, are the following phyficians and fur- geor.s : Mailer jacobus Fryle, king’s phyfician, 2s. per diem, with twolervants at 6d. per diem; Mafter William Hobbis, phylician and furgeon of the king’s body, iSd. per diem; feven furgeons at i2d. and five other furgeons every one at 6d. per diem, for their attendance in the faid fervice beyond fea. It is remarkable, that here are juft twelve furgeons, the fame number that appears to have been employed on the expedition under Henry V, In the expedition to St. Quintin’s in the reign of Philip and Mary, 1557, an army confiding of five hun¬ dred heavy armed horfe, five hundred light horfe, four thoufand foot, and two hundred pioneers, with officers and a train of artillery proportionable, there were fifty- feven furgeons, tw’o of them belonging to the fuite of the general, one to the lieutenant-general, one to the high marifchal, one to the general of the horfeman, one to the general of the infantry, and one to the mafter of the ordnance ; all thefe at the daily pay of 1 s. each. The remainder belonged to the corps of horfe, light horfe, and infantry, in the proportion of one furgeon to an hundred men ; the daily pay of a furgeon of heavy horfe was 2s. of light horfe is. 6d. and of infantry is. No furgeon is charged for either the ordnance or pioneers. Befides the king’s pay, it feems as if the furgeons of former times, as well as thofe of late, received a weekly ftoppage from the private men. This may be gathered from the following defcription of the duties of a mili¬ tary furgeon, written in the reign of Queen Elizabeth, “Surgeons ffioulde be men of fobrietie, of good con- fcience, and fkillfull in that fcience, able to heal all foares and woundes, fpecially to take oute a pellett oute of the fame. All captaines muft have fuche furgeons, and ought to fee them to have all their oyles, balmes, falves, and inftruments, and necefiary ftuffe to them be- longinge, allowinge and fparinge carriadge for the fame. That every fouldier, at the paye daye, doe give unto the furgeon 2d. as in tymes paji hathe bcene accujlomed, to the augmentation of his wages ; in confideration whereof, the furgeon oughte readilieto employ his induftrie uppon the foare and wounded fouldiers, not intermedlinge with any other cures to them noyfome. Regarde that the furgeon bee truelye paid his wages, and all money due to hym for cures, that bye the fame hee maye bee able to provide all fuche ftuffe as to him is needfull. Such fur¬ geons mufte weare their baldricke, whereby they may be knowen in the tyme of daughter : it is their charter in the field.” From this paffage it Ihould feem that fur¬ geons formerly wore a diftinguilhing belt over their ftioulders, like that now ufed by the itinerant farriers, vulgarly ftyled fow-gelders, in order to prote6l their per¬ fons whilft adminiftering to the wounded in the field of battle ; a precaution now rendered unneceffary by the apparatus of bandages, &c. carried by furgeons attending a party where fervice is expeiled, or in a field of battle. In an eftimate made, anno 1620, for an army of twen¬ ty-five thoufand foot, five thoufand horfe, and twenty pieces of artillery, propofed by king James to be fent to the Palatinate, a number of furgeons is appointed, but no allowance or provifion whatever appears in the efti¬ mate for medicines or an hofpital, although there is a very minute detail of almclt every other necefiary (lore ; and this feems the more extraordinary, as many of the moft experienced officers of that time were called in to affift in forming the eftimate. The medicinal lift appointed for this expedition were : “ In the general’s trayne, two phyficians, at 6s. 8d. per diem each ; two apothecarys, at 3s. 4d. and two furgeons, each at 6s. 8d. Every regU mentof foot confifted of twelve companies of 150 men each, and had one chief furgeon, at 4s. per diem, and another furgeon to each company at is. per diem. Among the general officers of horfe is one chief furgeon at 4s. a- day, probably to fuperintend the furgeons of troops. To every troop, which was to confift of a hundred men, one furgeon was allotted ; his daily pay, 2S. 6d. To the ord¬ nance, pioneers, &c. there was allowed one barber-fur- geon, at 2s. per diem ; and two under barber- furgeons, at 6d a-day each.” Or.e realon may be affigned for our ancient armies being 25 PATHOLOGY. being able to do with fo fmall a number of furgeons ; which is, that, immediately after a battle, fuch of the meaner fort of foldiers, whofe wounds feemed to require a con- fiderable time for cure, were by the general difmifled, with a fmall pecuniary provifion to carry them home : this, according to Barnes’s Hillory of Edward III. was done immediately after the battle of PoiSliers. Perhaps likewife the inferior furgeons, ftyled barbers, were taken from the ranks, and therefore paid and multered as pri¬ vate men. The prafticeof medicine did not keep pace in improve¬ ment with anatomy and furgery. In the early part of the i6th century the moll conspicuous name we meet with is that of Paracelfus. This- bold and conceited che- mill, who had been' greatly neglefted in his education, endeavoured to combine the principles of alchemy, me¬ dicine, and altrology. He travelled much in fearch of remedies, which he did not difdain to accept from old women, gipfies, and conjurers. He acquired very great reputation ; and on his return to Germany he was ap¬ pointed profeffor of furgery to the univerfity of Bade. The pathological dodlrines of Paracelfus are very im¬ perfectly underltood. It appears, however, that he ad¬ mitted three component parts of the animal body, fait, mercury, and fulphur. We mull not fuppofe that he carried his notions fo far as to conceive that thefe che¬ mical fubllances were really exillent in our frame. On the contrary, he appears to have merely ufed the above- mentioned terms to ill ullrate his meaning by analogy. Thus, mercury is fuppofed to mean the principle of fluid¬ ity, fulphur that of inflammability, and fait folidity. The vital principle of Paracelfus he denominated Archaus$ it was feated in the Itomach, and was the principal agent in digeftion; it feparated the noxious, and prepared for aflimilation the nutritious, parts of our aliment, with a great deal of intelligence, and was the principal agent in the recovery and prefervation of health. Paracelfus like¬ wife mentioned a humour as producing difeafe, though he had abufed with fo much virulence the humoral pa¬ thology of Galen. This humour he called Turturus ; it produced rigidity of the folids, vifcidity of the fluids, See. but it fhould be remarked, that this author did not, like Galen, impute difeafe to the prefence of humour, but humour to difeafe; for the proximate caufe of this Tartarus he contended was the irregular aCtion of the Archsus, or prefiding fpirit. He moreover mentioned five remote caufes of difeafe, viz. ens ujlrule, ens veneni, ens naturale, ens fpirituule, and ens deale. Diverted of che¬ mical jargon and obfcurity, the theory of Paracelfus feems to be this. He remarked, with many others before him, the three principles of the animal frame ; folidity, fluidity, and contradlility or irritability ; and he endeavoured to trace their origin in fubllances which poflefl'ed properties bearing to them a remote analogy. In the fecond place, in tracing the phenomena of difeafe, he referred to the defective or inordinate energy of the vital power the alfi- snilation of noxious particles of food into the blood: hence a humour which, circulating in all parts, produced the varied phenomena of difeafe. Paracelfus in his prac¬ tice ufed the chemical remedies with fome luccefs : he has the merit of firft introducing mercury as a cure for the venereal difeafe, which had before his time been treated with inert quintefcences, diet-drinks, guaiacum, Sec. He was likewife the fit'll who prefcribed opium freely ; and he was no friend to that abfurd practice, which had come into vogue with the Arabian phyficians, of com¬ pounding 50 or 60 fimples together, under the miftaken notion that all the fubllances would retain and exert their feparate virtues, or that among fo great a number forne- thing would be found applicable to the cafe. Modern pharmacy may be faid to commence about the middle of the fifteenth century, at which time it appears to have been in a moll deplorable ftate of empirical bar¬ barity. Though it is probable that, among the earlier pradlitioners of medicine, remedies were employed in Vol.XIX. No. 1284. their moll Ample forms, the art of compounding a num¬ ber of fimples together into one medicine had, by the time of which we are now fpeaking, arrived at a pitch of extravagance which has never been exceeded. What carried this oftentation of compofition to thehigheft ex¬ cels, was the project of framing antidotes, which being previoufly adminiftered, might defend againft any poifon whatever that fliould afterwards be taken into the body. To this fcheme is owing the multitudinous compofition of the celebrated Mithridate and the Theriaca; for fuch medicines muft of courfe recommend themfelves by the number and variety of their ingredients, as they were to contain a proper antidote for every poflible fpecies of poifon, and more el'pecially as thefe compofitions were to be farther wrought up into little lefs than univerfal remedies forall difeafes to which the human body is fubjedt. The firft of thefe antidotes was faid to be compofed from the refult of experiments made feparately with all kinds of Ample antidotes by the famous king whofe name it bears 5 but, as no records are left us of any of thofe particular experiments, we may reafonably confider this tale as fabulous. As’ it is not likely that this medicine or the Theriaca will ever again appear in our Pharmaco¬ poeias, we Ihall, for the amufement of our readers, de- feribe the compofition of each, as given in the London Pharmacopoeia publifhed in 1746. The Mithridate is thus compofed. “ Take of cinnamon 14 drams, of myrrh n drams ; agaric, fpikenard, ginger, faffron, feeds of treacle muftard, or of mithridate muftard, frankincenfe, Chio turpentine of each 10 drams; camel’s hay, coftus, or in its Head ze- doary, Indian leaf, or in its Head mace, French lavender, long pepper, feeds of hartwort, juice of the rape of cif- tus, ftrained ftorax, opoponax, (trained galbanum, balfam of Gilead, or in its Head exprefled oil of nutmegs, Ruffian caftor, of each an ounce ; poley-mountain, water-ger¬ mander, the fruit of the ’balfam-tree, or in its Head cu- bebs, white pepper, feeds of the carrot of Crete, bdellium ftrained, of each feven drams; Celtic nard, gentian-root, leaves of dittany of Crete, red rofes, feeds of Macedonian parfley, the lefler cardamom-feeds freed from their hulks, fweet fennel-feeds, gum Arabic, opium ftrained, of each five drams ; root of the fweet flag, root of wild vale¬ rian, anile-feed, fagapenum ftrained, of each three drams ; fpignel, St. John’s wort, juice of acacia, or in its Head Japan earth, the bellies of feinks, of each two drams and a half; clarified honey, thrice the weight of all the reft. Difl'olve the opium firft in a little wine, and then mix it with the honey made hot; in the mean time melt toge¬ ther in another veffel the galbanum, ftorax, turpentine, and the balfam of Gilead, or the exprefled oil of nutmeg, continually ftirring them round, that they may not burn ; and, as loon as thefe are melted, add to them the hot honey, firft by fpoonfuls, and afterwards more freely: laftly, when this mixture is nearly cold, add by degrees the reft of the fpecies reduced to powder.” The preparation of the Theriaca Andromuchi, or Venice treacle, is thus directed. “Take of the trochesof fquills, half a pound; long pepper, opium ftrained, dried vipers, of each three ounces; cinnamon, balm of Gilead, or in its Head exprefled oil of nutmeg, of each two ounces ; agaric, the root of Florentine orris, water-germander, red rofes, feeds of navew, extradl of liquorice, of each an ounce and a half; fpikenard, faffron, ammomum, myrrh, coftus, or in its Head zedoary, camel’s hay, of each an ounce; the root of cinque-foil, rhubarb, ginger, Indian leaf, or in its Head mace, leaves of dittany of Crete, of horehound, and of calamint, French lavender, black pepper, feeds of Macedonian parfley, olibanum, Chio turpentine, root of wild valerian, of each fix drams ; gentian-root, Celtic nard, fpignel, leaves of poley- mountain, of St. John’s wort, of ground-pine, tops of creeping-germander with the feed, the fruit of the balfam-tree, or in its Head cubebs, anifefeed, fweet fen¬ nel-feed, the lefler cardamom-feeds freed from their H hulks, 20 PATHOLOGY. hulks, feed of bilhop’s-weed, of harttvort, of treacle- muitardor mithridate-muftard, juice of the rape of ciftus, acacia, or in its ftead Japan earth, gum Arabic, iforax drained, fagapenum ftrained, Lemnian earth, or in its Head bole-armenic or French bole, green vitriol calcined, of each half an ounce ; root of creeping birtluvort, or in its Head of the long birthwort, tops of the lefler centaury, feeds of the carrot of Crete, opoponax, galbanum ftrained, Rullia'caftor, Jews pitch, or in its Head white amber pre¬ pared, root of the fweet flag, of each two drams ; of cla¬ rified honey thrice the weight of all the reft. The ingre¬ dients are to be mixed in the fame manner as in the Mithridate.” The Theriaca may be confidered as a modification of the Mithridate by Andromachus, though we are not informed what were his reafons for the varia¬ tions, except that by the addition of the viper’s fielh the medicine was rendered more ufeful againft the bite of that animal. The Theriaca was in fo great repute before the decline of the Roman empire, that even the wife Marcus Aurelius was induced to make a daily ufe of it, to' the great prejudice of his health ; for we are told by Galen, that his head was fo much affedted, that he dofed in the midft of bufinefs ; and, when on this account he omitted the opium in the coinpofition, he could not lleep at all. When the alchemifts had extended the bounds of their art from the mere drudgery of manufacturing gold and filver to the more noble and phiiofophic employment of compoling an univerfal elixir that fhotild fecure its pof- fefior from difeafe, and prolong his life to an indefinite period, pharmacy derived from their labours confiderable and folid advantages. The experiments inftituted by thefe vifionaries with the metals, led to the accidental difcovery of fome of the molt efficacious remedies which we at prefent employ, efpecially the preparations of anti¬ mony and mercury, and molt of what are called the neu¬ tral or fecondary 1'alts. By calling in the aid of fire, they ’ enabled us to produce in bodies changes which, with¬ out the affiftance of this powerful agent, we fhould have been unable to efl'eCt. Now, every thing was fubmitted to digrjhon, calcination, fermentation, diftillation , and fitb- limution-, but, as generally happens in cafes of innovation or reform, thefe new methods of obtaining active reme¬ dies were carried to an abfurd and ridiculous extent. Finding that the healing powers of many fubftances were eliminated or increafed by the application of heat, they feemed to imagine that the fimple medicine could in no cafe poffefs any medical virtue till it had been placed upon the fire or kept for fome hours in a furnace. Hence the immenfe number of diftilled waters and fpirits, elfential and empyreumatic oils, with which the old pharmacopoeias are crowded, and which feem in many cales to poliefs no other powers than what they de¬ rive from the water or the fpirit that forms the bulk of the preparation. Not only plants and minerals, but ani¬ mals and animal matters of all kinds, were diftilled, di- gefted, or calcined. Thus, we find a water of Jhails, a fpirit of millepedes , an oil of earth-worms. See, See. The abfurd and pompous names by which the preparations were diftinguifned, are truly ridiculous. Magijierial balfqm, Hicra picra, Ethiops mineral, Ens Veneris, Flores Martis, Calmnclas, Aqui'tu alba, are a few which long re¬ tained their feat both in public and private difpenfatories. As’ thefe preparations were, from their contrivers, deno¬ minated chemical, the more ancient medicines which ■were drawn almcft entirely from the animal and vege¬ table kingdoms, were denominated Galenical, becaufe chiefly employed by the followers of Galen. Hence the divifion of medicines into Galenical and Chemical, a divi- fion which obtained for fome hundred years, and which only a few years ago was prelerved in the fale-caialogues of the London druggifts. The chief follower of Paracelfus was Van Helmont. He made many important chemical difcoveries ; ftrongly op- poled the Galenical dodlrir.e ; and, though often milled in his fpeculations by a ftrong bias to theofophifm, he ob- ierved Nature very attentively; he pointed out more fully than Paracelfus had done, the influence of the epi- gaftric organs on all the other parts of the lyftem ; and he gave fome account of the origin of urinary calculi. The nature of inflammation was likewife explained by him, and the pernicious confequences of exceffive bleeding welfpointed out. Van Helmont had not, however, many adherents at the time he lived. His theory was afterwards taken up by Defcartes, who attempted to explain all the phenomena of life according to chemical and mechanical principles. Thus, the circulation of the blood and animal heat were produced, according to him, by the ebullition or fermentation that took place in. the heart; digeltion was likewife performed by a fpecies of fermentation ; and the fenfation of hunger proceeded from the acid which was evolved during the procefs. To explain the nature' of fecretion, Defcartes had recourfe to> the corpufcular philofophy; comparing the fecreting organs to lieves, which allowed only the more minute and homogeneous particles to pafs through, while the coarfer and hetero¬ geneous bodies were rejected : the round particles were luppofed by him to enter into cylindrical tubes ; pyrami¬ dal particles penetrated by triangular pores, and cubical particles by fqtiare pores; and in this way each fecretion remained diftindt, at leaft in the healthy ftate. Thefe ideas were eagerly embraced by the Dutch phylicians of the time, and may be confidered as forming the ground¬ work of the chemical and mechanical fyftems, which di¬ vided the medical world at the end of the fevenreeuth cen¬ tury, notwithftanding the claims to originality which le- veral of their followers have put in. After the revival of genuine philofophy in the fixteenth century, it might naturally be expected that medical fci- ence would immediately avail itfelf of its light, and par¬ take of its benefit; but this was fo far from being the cafe, that, in the firft inftance, it proved a new fource of error, and threw f re fin impediments in the road which was fuppofed to be opened to the improvement of rational medicine. The difcovery of the circulation of the blood may, indeed, be confidered as one of the firft fruits of the inquiries into nature begun in that age. But, though this is a fundamental element in the economy of the living body, it throws little or no light on the principles' peculiar to life, being purely of a mechanical nature ; and, abftradtedly confidered, hardly admits of any application to the pradiice of medicine. On the contrary, this difco¬ very, by its perverted application, tended to corrupt and millead, by a loofe adoption of the principles of mechani¬ cal philofophy, fo well laid down in that age by Galileo and others. Boreili, in inveftigating the force of the heart by experiment, eftimated it at 180,000 pounds; Hales, at 51 pounds; Keil, at 1 pound. The mechanical powers of the ftomach were, about the fame time, fub- jedled to experimental refearch by Pitcairn, who gravely gave out that he found this vifeus, in the human lubjedt, exerted a force equal to 12,900 pounds, in compreifing food in the procefs of digeftion. Others, conceiving that chemical power had the chief lhare in this fundlion, en¬ deavoured to evince that the change in the foot! was brought about by means of heat and fermentation. Sounder principles have referred thefe changes to powers which have nothing in common with the mechanical and chemical powers which characterize inanimate nature. From the picture that has been exhibited of the innu¬ merable doubts and difficulties which clog the attainment of medical knowledge, and embarrafs the application of it to pradrical purpofes, the timid, fceptical, and indolent, may be difeouraged from ftudies apparently fo arduous in their prol'ecution, and fo queftionable as to the efficiency and utility of their refult. But it i§ not from charadlers of this defeription that much good can be expedled in any of the ufeful arts of life, If a like defpondency were to pervade mankind in general, there would be an end to all that enterprife and energy which alone can enable them to 27 PATHOLOGY. to aft up to their deftiny, and follow up thofe purfuits upon which the perfection of their nature depends. As the fenfes would have lain dormant for ever had there been no external objefts to dimulate them, fo the faculties and virtue which characterize rational nature and civilized life could never have been developed, but through the excitement of thofe pains, wants, difficulties, and dangers, infeparable from human life. By no other arrangement could our duties, our happinefs, our mental and bodily perfections, have been bound togetherin one harmonious and confillent fyltem. Let us compare the art of medi¬ cine, under this afpeCt, with thofe of navigation and agriculture. Had man been furniffied by the Creator with wings, by which he could have traverfed all feas and oceans, fo as to fuperfede the life of ffiips, where would have been that hardihood of character, and ail thofe inge¬ nious devices which have called forth the aCtive energies and deep refearches of the human mind ? If, contrary to the aCtual inltitutions of Providence, the life of man had been fuftained by the fpontaneous productions of nature, inftead of the products of indudry, neither the faculties of the mind nor the powers of the body could ever have been developed : man would have been little fuperior to the brutes; his aCtive and inventive energies would have lain alleep for ever ; there would have been no room for the talents exercifed in the procuring of food, raiment, and Ihelter, r.or in commercial intercourfe; all the mutual and endearing ties and dependences of facial and civilized life, all trades, profeffions, arts, and fciences, whether miniltering to accommodation or elegance, conilituting man's greatelt felicity, whether as objefts of purfuit or enjoyment, would have been unknown and untafted. It is obvious that this reafoning, being founded on a general law of nature, mud apply equally to medicine. In a pro¬ bationary exiftence, it was neceffary that man ffiould be tried, not only by pain and ficknefs, but by the difficul¬ ties of remedying them, as exercifes of virtue and inge¬ nuity. Why ffiould the road to medical relief lie through fewer and (lighter druggies and dangers, than thofe of navigation and agriculture ? But the fubjeCt is more concifely and emphatically illudrated by the philofophical poet, than by any amplitude of illudration, or farther multiplicity of words which we could employ : . - Pater ipfecolendi ( medendi), Haud facilem efle viam voluit, primuique per artem, Movitagros, (ggros,) curis acuens mortalia corda. We ffiall conclude our view of the general date of pa¬ thology in the lixteenth century, with fome account of the violent difputes which prevailed in France, on the prero¬ gatives of the medical art over thofe of furgery, but par¬ ticularly on theconteded privileges of the furgeons. Al¬ though the documents relative to this fubjeft have been partly printed, or have at lead not been withheld from the inlpeftion of hidorians, yet no part of medical hidory has been condufted with more partiality, and lei's regard to truth, by both parties. The author of the work entitled “Recherches furl’Origine et la Progres de la Chirurgie en France” is guilty of the grolfed mifrepreferitation, though this book has by fome been afcribed to Franc. Quefnay. Pafquier, in his “Recherches de la France,” fol. Paris, 1620, defervesmuch more credit; and, therefore, the mod important points relative to that extraordinary difpute are here briefly collefted from his more authentic Aatement. And this alfo will remind the reader of flmilar difputes in our own country, and about the fame time : for, it has been already hinted, that, during great part of the 16th century, furgery was praftifed indilcriminately by barbers, farriers, and fow-gelders. We know that barbers and furgeons continued for 200 years after to be incorporated in one company, both in London and Paris. d In Holland and fome parts of Germany, we are told, that, even to this day, barbers exercife the razor and lancet alternately. The furgeons of Paris had, fince the time of Lanfranc, (1295), formed a didinft body, called the College of St. C6me ; and they obtained additional and refpeftable pri¬ vileges from Philip the Fair, in 1311, which entitled them to equal rank with the members of the medical faculty; hence they could not bear the idea that barbers ffiould ul’urp the right of bleeding, applying pladers,and treating external injuries and ulcers. In confequence of this en¬ croachment, the furgeons, in 14.25, obtained an aft or arret of the parliament of Paris, by which the performance of chirurgical operations was prohibited to the barbers, while they were permitted to drel’s wounds, and extirpate corns by the knife. But the phyflcians embraced the caufe of the barbers, and indrufted them in the practice of furgery, with a view to take revenge on the furgeons, who, it was affirmed, had ufurped medical privileges. The complaint of grievances which the furgeons, on this occaflon, laid before the faculty, in the years 14.91 and 1494., were not attended with any efl'eft; and the members of the faculty were even permitted to deliver anatomical leftures to barbers in the French language. The furgeons again, though in vain, reprefented to the faculty, that they afted contrary to the laws made by themfelves, by permitting their members to indraft barbers' in the knowledge of anatomy, and this in their native language. However, no other redrefs could be obtained, but that of licenftng the furgeons to undertake public difleftions, and of granting them a certain rank above the barbers, for which they paid lixty folidos annually to the treafurer of the faculty. This event took place in the year 1 502 ; and in 1505 the furgeons renewed their application in the charafter of fcholars or pupils to the faculty, whom they intreated to confirm their privileges; but Helin, the fenior of that body, fent them the difcouraging anfwer, that their pretended rights or immunities had been ac¬ quired by furreptitious means. In the fame year, the phylicians of Paris, as Pafquier exprefles himfelf, “ palled the Rubicon,” and entered into a formal contraft with the barbers, who, on account of their implicit obedience, were patronized in preference to the furgeons. The barbers were confequently, in con¬ tempt of the furgeons, pronounced to be “ the true fcho¬ lars of the faculty:” they were matriculated under that name; but a promife was exafte'd from them, according to which they were not allowed to adminider internal medicines, without confulting, in every cafe, a member of the medical faculty; they farther agreed to undergo an examination, previous to their commencing bufinefs as maders. After that period, the barbers were no longer called Barbitovfores, the complaifmt faculty having con¬ ferred on them the more honourable title of Chiriirgici a. Tonjtrina, or TonJ'o'res Chirurgici. A few days after this change, the faculty proceeded to fuch extremities as to profecute the furgeons in a court of law, becaufe they had received information, that leveral furgeons had prefcribed internal remedies without the previous advice of a phyfician. At that time, probabty, no man of genius and aftivity prefded over the Coliege of St. Come ; for no fooner was Stephen Barat elefted prefident of that college, than the fituation of affairs was thoroughly changed. In the year 1515, he urged the faculty to exempt the fociety of fur¬ geons from the oppreffive tax they were obliged to pay an¬ nually, and not to compel them to attend the leftures given by members of the faculty. As Barat addrefl'ed himfelf to the whole univerfity, and as old Helin, the mod zealous antagonid of the furgeons, died in the fame year, this remondrance had the deiiredefleft. The univerfity ilfued a decree, by which the furgeons of Paris were no¬ minated Scholu/tici, or perpetual fcholars of the faculty. But diil greater immunities were granted to the furgeons in 1545, by the good offices of William Vavafleur, principal furgeon at the court of Francis I. He effefted a complete feparaticn of the barbers from the furgeons ; and at the fame timeobtained a decree, in conformity to which every mafler of the chirurgical art, if he wiffied to obtain the privilege PATHOLOGY. privilege of exercifing his profeflion, was obliged to ftudy the Latin language, logic, and other elementary fciences. By this favourable regulation, the College of Surgeons was at once raifed to the rank of a learned fchool, and obtained at length the right of creating Mailers, Bache¬ lors, Licentiates, and Doctors, of Surgery. In confequence of this arrangement, Henry II. granted to the members of the Chirurgical College of St. Louis, all the preroga¬ tives attached to a faculty ; and the patent ifl'ued on that occafion was regiftered in the parliamentary laws, under the name of Lettres d'Ociroi. In the j’ear 1551, the medical faculty, under the deanery of John du Hamel, re-commenced the difpute againll the furgeons. Although Rudolph le Fort, dean of the College of St. Louis, zealoufly defended the fur¬ geons, yet du Hamel found the means of procuring a re¬ peal of the decree enadled in 15155 and, contrary to the fpirit of that law, the furgeons were again obliged to fub- mit to an examination before the medical faculty. Under Henry III. however, the furgeons once more obtained a confirmation of their privileges, in 1577, by virtue of which they were entitled to confer academical dignities ; and, notwithftanding the newoppoiition of the faculty in 1579, the furgeons, as well as the univerfity of Paris, were in the fame year favoured with an indult of pope Gregory XIII. while de Thou vindicated the caufe of the former, in a fpirited and fuccefsful manner, againft the opprelfions of the faculty. The colleges fubfequently eitablilhed by fur¬ geons acquired fuch a degree of authority, that, in the year 1596, they were empowered to give poll tive orders to the barbers, in difficult chirurgical cafes always to con- fult a fworn furgeon, and upon no account to undertake the treatment of any other but the flighted: external inju¬ ries. Thefe privileges and prerogatives of the furgeons of Paris were further confirmed by Henry IV. in 1602, and by Louis XIII. in 1614. About this time was framed the following oath, which to this day is taken by every phyfician who takes a degree at the univerfity of Montpelier. “ I, ■ -, be¬ fore the image of Hippocrates, in prefence of the profef- fors of this fchool, and of my dear fellow-coilegians, do fwear, in the name of the Supreme Being, to be faithful to the laws of honour and probity in the exercife of medicine. I will give my care gratuitoufiy to the indigent, and will not exa6t a falary beyond my juft demands. Admitted into the interior of families, my eyes fhall not fee what they ought not to fee, nor fhall my tongue betray any fecrets confided to me 5 nor fhall my profeflion be made available to corrupt morals, or to favour guilt. Re- fpeFtful and grateful to my mailers, I will endeavour to return to their children the inltrmSlion which I have gathered from the fathers. May men grant me their efteem in proportion as I am faithful to this oath ; and may I be difgraced among my colleagues when I fwerve from it.” III. From the Seventeenth Century to the present Time. The moll brilliant difcovery of the 17th century was that of the circulation of the blood, by our countryman Harvey, who was born in the year 1578. He firft opened the difcovery in 1616, in his leisures in the Latin lan¬ guage, which are preferved in MS. in the Britiffi Mufeum ; but his work, containing the details, was not publifhed till the year 1628, when his “ Exercitatio anatomica de Motu Cordis et Sanguinis in Animalibus” appeared at Frankfort : and this is the only edition which bears the ftamp of Harvey’s own authority. This treatife, which Haller has moll appropriately flyled aurcum opufcuhm, is conftrucled entirely upon the refult of experiment, and contains an excellent arrangement of the fubjefit. The author was now created phyfician to king Charles I. and demonflrated the circulation before him in a living animal. The vail importance of this difcovery to the whole fcience of phyfiology; the influence which it neceftarily exerted on the doftrines of pathology ;■ and the general revolution which arofe from this fource throughout the whole circle of medical knowledge; will juftify us in giving a flight hillorical fxetch of the fubjecl, and in pointing out the opinions held by thofe anatomifts and phyiiologifts who preceded- our immortal countryman Harvey. To him, indeed, the glory of this greateft of all phyfiological difcoveries has been affigned by the almoft unanimous concurrence of his fucceffors. Some, however, have endeavoured to deprive him of his well-earned fame, by afcribing a knowledge of the circulation to various preceding writers. Mr. Dutens, in the fecond volume of his “ Recherches fur l’Origine des Decouvertes attributes aux Modernes,” has brought forward paflages from Hippocrates, Plato, Ariftotle, Julius Pollux, Apuleius, and others, in order to prove that they knew the courfe of the blood. After the pofitive dogmatical alfertions with which the author fets out, we are furprifed by the weaknefs and inadequacy of his proofs, and can only ac¬ count for the inconfiftency by fuppofing him to have been utterly ignorant of the fubjedl. He quotes a few inf¬ lated paflages which cannot, by the moll favourable inter¬ pretation, beconftrued into the femblance of a proof, that the writers in queftion knew the circulation of the blood. But the only fair and unexceptionable method of deter¬ mining whether any individual was acquainted with a particular fa 61, is to confider all that he has faid on the iubjedl, and to draw our inferences from the refult of this general examination. Such an inquiry will prove moll clearly, that a knowledge of the circulation, fuch as we pofiefs at prefent, can be afcribed to no one before Harvey ; although a part of the fubje£t,viz. the paflage of the blood through the lungs, had been defcribed by feve- ral perfons before the time of that illuftrious character. That the blood moves, has been univerfally known and admitted, fince the fcience of medicine has aflfumed a dif- tinfl form : how much of its courfe, and of the laws that regulate its motion, has been afcertained at any given pe¬ riod, is another queftion. The circulation is fo generally known in the prefent day, and the proofs on which it refts are fo obvious and familiar to every tyro in the profeflion, that we feel furprifed how they Ihould fo long have ef- caped the obfervation of the numerous ingenious and learned characters, whofe names adorn the annals of ana¬ tomy. We muft remember that the courfe of the blood, taken altogether, forms a fubjeft of confiderable intricacy; that the purfuit of anatomy was attended in the early periods of the fcience with confiderable difficulty and danger; and that the unlimited fway which the authority of Galen held over the minds of men for fome centuries, precluded all attempts at further inveftigation. Hippocrates Hates that the blood meets with obftacles in its courfe, which retard or entirely arreft its progrefs; that it goes from the internal parts towards the furface ; and vice-verfd, that the blood muft flow forwards from the heart, fince the valves hinder its return, and that the arteries are diftended when their blood is flopped. In fpeaking of the blood’s motion, he compares it to the courfe of rivers, to the ebbing and flowing of the fea, and even to the revolutions of the planets. He affigns the origin of the arteries to the heart, and that of the veins to the liver; and fuppofes that there are two oppofite mo¬ tions in the temporal arteries, by which their pulfations are produced. He fpeaks of four fluids in the body, the blood, water, mucus, and bile, which come from the heart, head, fpleen, and liver; all thofe parts are, how¬ ever, fuppiied from one principal fource, the ftomach. Can we difcover any traces of a knowledge of the circu¬ lation in this confulion of ideas; and may we not be jullly furprifed, to find that enlightened men Ihould be fo led away by their prejudices, as to allow to Hippocrates the knowledge of a difcovery, which no one had per¬ ceived in his writings for nearly three thoufand years ? The obfervations of the founder of medicine had led aftray x PATHOLOGY. a ft ray all who followed him to the time of Harvey; but, when the refearches of that great man had unfolded the myftery of the circulation, his enemies dared to affirm, that the writings of Hippocrates had furnilhed the lights which guided him in the path of difcovery. The philofophers who joined theftudyof medicine to that of the other fciences, feem to have been equally ig¬ norant of the laws which regulate the blood’s motion. Thus, Ariftotle exprefsly ftates that the blood never re¬ turns to the heart. The Alexandrian anatomifts main¬ tained that the arteries held no blood, but were filled with air; from which circumftance they gave them the name, which they have conftantly retained, from a»p, air, and T'/jfsw, to hold. To explain the occurrence of blood in thele veflels after death, they fuppofed the exiftence of fubtle communications with the veins. The genius of Galen difdained to follow blindly the iteps of his predeceffors ; and he endeavoured at leaft to difcover the truth by experiments and obfervations on the ftrmSture of the body. By thefe means he afcertained fome fafts, although he could not fucceed in piercing the veil which concealed the fecret of the circulation. He feems to have recognized the ufe of the valves at the two orifices of the ventricles. He proved, by tying an artery with two ligatures, that thefe veflels contain blood during life; and ftates that they are filled by the contraction of the heart, in confequence of which they pulfate. Thefe circumftances feem to indicate a confiderable advance¬ ment in the knowledge of the circulation ; but we mult mention, in the fame fpirit of impartiality, the contradic¬ tions and uncertainty which prevail in the works of Galen on this fubjeCt, and the limits which his labours could not exceed. He ftill referred, with Hippocrates, the origin of the veins to the liver, and fuppofed a paflage of the blood through thefeptum of the ventricles, while a fmall portion entered the pulmonary artery to nourilh the lungs : he imagined, lallly, that it might pafs recipro¬ cally between the pulmonary artery and veins. There could be little reafon to expeCt, that in the troubled and barbarous times which followed the age in which Galen fiourilhed, the fecret of the circulation fliould be difcovered ; ftill lefs that it Ihould be explained to phyficians by men whofe purfuits were foreign to the fcience of medicine. Yet it has been boldly afierted that Nemefius, bifhop of Emefa, knew' the courfe of the blood, as it has been afcertained by the fubfequent la¬ bours of Harvey. The editor of the Oxford edition of his works, has imbibed the true fpirit of a commentator ; who difcovers in the writings of the ancients, meanings which never were in the contemplation of the authors; and abufes the moderns as plagiarifts, for decorating themfelves with the difcoveries of antiquity. But on what grounds does Nemefius claim the honour of a difcovery, denied to fo many great geniufes ? Becaufe, according to Freind, the bifnop ftates, that the blood palfes from the arteries into the veins during fleep. This reftriftion im¬ mediately overturns the claim ; which would indeed be deftroyed by the kind of motion that he fuppofes to take place, viz. a reciprocal alternation of undulations, like that of the Euripus. In another paflage cited by Dutens, he fpeaks of the arteries in their dilatation attracting the blood from the veins; but this paflage, which we have already quoted at p. 16, fufficiently proves that he knew nothing of the matter; and exemplifies ftill further the abfurdity of a perfon’s attempting to dogmatize, as Dutens lias done, on fubjeCts of which, as being foreign to his profeflion, and difficult of inveftigation, he cannot reafonably be expected to be a competent judge. “Thus,” to ufe the words of Senac, “a theologian writes on the nature of man; a fubjedt which does not very properly belong to fuch a writer : on no other tefti- mony than fome vague and ridiculous expreflions, he gains the credit of knowing the circulation, of which the greateft phyficians and anatomifts had been hitherto com¬ pletely ignorant. Thus it is, that interpreters and com- Vol. XIX. No. 1285. 29 mentators are milled by a blind zeal for antiquity, and difcover hidden meanings in the moft Ample expreflions. How would their boldnefs and aflurance have been aug¬ mented, if Nemefius had exprefled himfelf as clearly as an ancient fcholiaft of Euripides has done, where he fays, “ that the blood flows through the veins, and that thefe veflels receive it from the arteries.” Should we, how'ever, on this infulated and cafual expreflion, be juftified in be¬ llowing on a weigher of words, and meafurer of phrafes, the honour of a difcovery, which had eluded the re¬ fearches of the greateft philofophers ? The date of darknefs and ignorance, in which the hu¬ man mind languifhed during the fucceeding ages, does not allow us to expeCt that any writer of that period can dif- pute with Harvey the honour of the great difcovery. About the fixteenth century the curiofity of mankind was again excited to the inveftigation of this interefting fubjeCl. Reafon, which had hitherto fubmitted to the yoke of authority, began to aflert her rights ; and feveral phyficians were bold enough to examine fubjeCts which Hippocrates and Galen had not been able to develope. Thefirft ray of light was thrown on the circulation, by a man, whofe name cannot be mentioned without ex¬ citing feelings of compaflion for his unmerited and barba¬ rous treatment, and of indignation at the unrelenting bigotry of. his cruel perfecutor. Gifted with an ardent and penetrating genius, Servetus made a rapid progrefs, at a very early age, in the fciences of natural philofophy and divinity. Compelled to leave Spain, his native country, he paffed into France, and ftudied medicine at Paris, under Winter d’Andernach, who was profeflor in the college lately fotinded by Francis I. He vifited dif¬ ferent parts of France and Germany, and, after various perfecutions on account of his religious opinions, fettled in Dauphiny. But Calvin, being too narrow-minded to grant to a rival that freedom of thought and liberty of confcience which he had fo 1'uccefsfully exerted in his ' own perfon, had him feized and condemned to the flames. Thus, fays Portal, “ one heretic deftroyed ano¬ ther ; but the difference was, that an ambitious and de- figning knave pronounced the condemnation, and one of the fineft and moft enlightened geniufes of Europe was the lamented vifitim of this iniquitous fentence.” The paflage, which proves Servetus to have been ac¬ quainted with the pulmonary circulation, occurs in his work de Rejiitutione Chrijlianifmi ; which, having been carefully deftroyed on account of the herefy which it contains, is now extremely fcarce ; fo that two or three copies only are fuppofed to exift, and the duke de la Valiere gave the fum of 1 32I. for one. It ftates, that the vital fpirit is compofed of the moft fubtile parts of the blood, and of the air, which infinuates itfelf into the lungs ; and that the fource of this blood is in the right ventricle. “But the communication, that is to fay, the paflage of the blood, from the right to the left ventricle, does not take place acrofs the middle feptum, as perfons have generally imagined ; it depends on a more Angular ftrufilure. In the long windings of the lung, this fubtile blood is agitated, and prepared by the aCtion of the vifcus, and gains a yellow colour. From the vena arteriofa (pulmonary artery) it palfes into the arteria venofce (pul¬ monary veins) where it becomes mingled with the air that has entered the lungs, and lofes its fuliginous excre¬ ments. Laftly, it enters the left ventricle, which attracts it in its dialtole. Such is the preparation of the blood, from which the vital fpirit is formed ; this prepa¬ ration, and this paflage from the arterial vein into the ve¬ nous artery, are evidently proved by the fize of the vef- fels; which would not be fo large,' nor poflefs fo many branches; nor carry to the lung fo great a volume of blood, if it were deftined to the nourifhment only of the vifcus.” He adds, that the vital fpirit is lent from the ieft ventricle into all the arteries of the body. This repre- fentation proves inconteftably that Servetus knew the minor circulation. He laid the foundation of a building, I which PATHOLOGY. 80 which had baffled all the efforts of the great geniufes of antiquity. In order to perfedt this defign, it was only ne- ceffary to extend the ideas of the firft architedt. He in¬ dicated the route, through which the blood paffes from the right to the left ventricle ; it remained to be proved that all the blood takes this paffage, and that it returns again to the heart from the arteries through the veins. The obfcure Iketch of the circulation, which was fur- niffled by Servetus, appears in a more finilhed and lu¬ minous form in the works of Realdus Columbus. He defcribes the entrance of the blood into the heart from the vena cava, and its fubfequent paffage through the lungs into the left ventricle and aorta. He advanced a ftep farther than Servetus ; for he dates that the whole blood paffes through the lungs, and not the vital fpirit only. But he falls into the fame error with preceding anatomifts on the fubjedt of the liver; fuppofing that gland to be the fource of the blood which nourilhes the ftomach, fpleen, & c. Arantius and Caefalpinus defcribed more perfedtly and clearly than Columbus the paffage of the blood through the lungs ; which they confirmed by feveral arguments drawn from the ftrudture of the parts, and particularly from the pofition and mechanifm of the valves. The latter indeed approached very nearly to the grand deiideratum, the paffage of the blood from the ar¬ teries through the veins to the heart. He obferves that a vein fwells below' the ligature; but he did not follow this up to prove the circulation. He fays that the blood returns to the heart through the veins during fieep; but he fuppofed it to move backwards and forwards in the fame veffels, like the Euripus. He was milled alfo in the labyrinth of the liver, where fo many phyfiologifts have loft themfelves. The arrangement of the arteries and veins in this organ prefents fuch an intricate combi¬ nation, that we need not wonder at its proving, for fo long a time, a fource of miftake and illufion. Paul Sarpi, the learned hiftorian of the council of Trent, is one of thofe to whom the circulation is faid to have been knowm; but the want of all arguments that bear the leaft convic¬ tion on the fubjedt, will juftify us in declining any par¬ ticular consideration of his claim, as well as thofe of Fabri a Jefuit, of Helvicus Dietericus, and others. Notwithftanding the labours and writings of the ana¬ tomifts whofe opinions we have thus curforily examined, the minds of men were ftill enflaved by thofe errors, which, having prevailed for fo many centuries, had ac¬ quired the fandtion which time and authority beftow on any opinions, however abfurd. The moft enlightened phyficians were fatisfied with the labours of their precie- ceffors ; and Harvey alone had fufficient courage and in¬ formation to canvafs thefe inveterate prejudices, which length of time had confecrated as infallible truths. He obferved and defcribed the true courfe of the blood with a wonderful fagacity and clearnefs. None of the argu¬ ments, which prove the circulation, efcaped the refearches of this acute obferver; fo that a modern phyfiologift, in recounting the proofs of this phyfiological fadl, could add little, if any thing, to what is accumulated in the ori¬ ginal work of Harvey. He was not contented with de- monftrating the circulation in fome parts only ; but fol¬ lowed up the fubjedt in all the vifcera of the body. He traced the courfe of the blood through the liver, where every preceding anatomift had difcovered nothing but perplexity and confufion. The work of Harvey is, in (hort, one of thofe rare and precious produdtions which embrace a fubjedt in its whole extent, and prefent it to the mind in fo perfedt and finilhed a form, as fcarcely to admit a tingle addition or improvement. The merits of our countryman, whofe fame can never perilh while medical fcience continues to be cultivated, will be exalted to a ftill higher pitch, when we confider the ftate of medical knowledge in England at that time. While anatomical fchools had been long eftablilhed in Italy, France, and Germany, and feveral teachers had rendered their names illuftrious by the fuccefsful purfuit of the fcience, anatomy was ftill unknown in England, where diffedfion had hitherto hardly begun. Yet, at this inaufpicious period, did Harvey make the difcovery, which may be considered as a fecond and more perfedt foundation of the fcience of medicine ; and which amply juftifies Haller in ranking him as fecond to Hippocrates only. The publication of this grand difcovery roufed the attention of all Europe. The old profeffors, accuftomed to pay a blind and implicit deference to the authority of Galen, which wras now utterly fubverted, and, aftiameci of confeffing that their whole life had been fpent in teach¬ ing the groffeft errors, took up their pens in oppofition to the author of thefe innovations. One party afferted that the difcovery was not a new one : that it had been known to feveral perfons, and, indeed, to all antiquity. Such were the aflertions of Nardi, Vander Linden, Hart- mahn, Almeloveen, Barra, Drelincourt, Patin, Falconet, Heifter, Regnault, &c. A fufficient refutation of thefe ftatements will be found in the hiftorical Iketch, which we have already exhibited. Other adverfaries of Harvey proceeded in a more rational manner; and attempted to difprove his ftatements by experiment and reafoning. Primerofeled the wayin this attack, and he was followed by Emilius Parifanus, John Riolan, Cafpar Hoffman, and others. If men of fuch acknowledged erudition as Riolan and Hoffman were fo utterly unacquainted with the circulation as to deny it altogether, may we not fafely conclude that the fubjedt is not defcribed in any of the writers who preceded Harvey ? Out of all his numerous opponents, this illuftrious man anfwered Riolan only, in his “Secunda et Tertia Exercitatio de Circulatione Sanguinis.” The reply was rather extorted by the rank and fame of Riolan, than by the ftrength of his argument. If we feek to define exactly the precife (hare of merit which Harvey may claim in the grand difcovery of the circulation, it will be necteffary to hold a middle courfe between the grofs and palpable ablurdity of thofe who difcover a knowledge of the circulation in the writings of Solomon, Hippocrates, Plato, Ariftotle, &c. and the too great partiality of fuch as would deny all knowledge of the fubjedt to every anatomift who preceded Harvey. It feldom happens, that fo extenfive and intricate a fub¬ jedt as that which we are now confidering, is furveyed and brought to light in all its branches by the labour of an individual ; nor has it happened in the prefent inftance. For Servetus, Columbus, Arantius, and Cae- falpinus, were acquainted with the courfe of the blood through the lungs ; and the latter writer has even an ob¬ fcure hint towards the greater circulation. But no one attempted to prove the latter point by arguments and experiment before the time of Harvey: the expreffions of Caefalpinus, which are by no means clear or fatisfadiory, had been before the public for half a century without exciting the leaft inveftigation, and without fuggefting to Fabricius the true office of the valves in the veins. The entire merit of the greater circulation may, there¬ fore, be afcribed to our illuftrious countryman ; and, if we compare the luminous method and irrefragable proofs which are found in his expoiition of the other part of the fubjedt, with the partial and confufed ftatements of pre¬ ceding authors, his merit will here be only fecond in de¬ gree to that of adtual difcovery. The dodtrine of the circulation met with fome fup- porters on its firft promulgation. Walaeus of Leyden ex¬ erted himfelf ftrenuoufly on this fide, and defended the propofitions of Harvey in two excellent letters addreffed to Bartholin. Des Cartes alfo, whofe authority at that time carried vaft weight with it, took a decided part in the controverfy in favour of Harvey, from its commence¬ ment. The dodlrine was pretty generally admitted throughout Europe before the deceafe of its propofer. The nature of the communication between the arte¬ ries and veins was left undetermined by Harvey, who decided no point which he could not make the fubjedt of experiment. 31 PATHOLOGY. •experiment. The art of injecting the veffels of the dead body, which has been difcovered and carried to great perfection fince his time, has Shown a continuation of canal joining the two fyftems of blood-veffels ; and the employment of the microfcope has completed the proof, by demonstrating the circulation in the tranfparent parts o ffrogs, See. during life. The transfufion of the blood o fone animal into the veifels of another, which has been performed with fuccefs in many inftances, has added another ftrong proof to the demonftration of the circu* iation. See the Hiftoire de l’Anatomie et de la Chi- rurgie of Portal, and the Bibliotheca Anatomica of Haller, in the articles concerning the writers whofe names are mentioned in this account. Francis de le Boe, otherwife Sylvius, was born at Hanau in 1614 ; and became profeflor of medicine at the univerfity of Leyden in 1658. He will be therefore readily distinguished from James du Bois, who is alfo called Sylvius, the mailer and violent adverfary of Vefalius, of whom we have fufficiently fpoken in the preceding Sedition. Francis Sylvius wasamuch morediltin- guiilied perfonage : he was alfo one of the earlieft advo¬ cates for Harvey’s doctrine of the circulation of the blood, and was the principal caufe of its reception into the medical ichool of Leyden. In other refpe'dts, how¬ ever, he was inilrumental in retarding the progrefs of medical fcience, by the invention of an hypothecs re- fpeCling the caufe of difeafes, which contributed much to excite the attention of the medical world, and to ex¬ tend his own fame. He aferibed all the morbid a<5tions of the vital fyftem to certain chemical operations, to fermentations, and ebullitions, which he believed gave origin to an excefs of acid or of alkali, to the neutraliza¬ tion of which all the efforts of the medical art were of courfe to be directed : whence he adminiltered volatile alkali, abforbent earths, and cordials, largely, paying little regard to the different llages of a diiorder, or the charafterof prevailing epidemics. The extent to which this doctrine was received and defended in molt parts of Europe, founded as it was upon a gratuitous hypothefis, and therefore produftive in many cafes of much mifehief, is furprifing, and the interruption which it occafioned to the improvement of medicine was confiderable. In faft, the chemical fyftem of Sylvius was admitted in almoll every country in which chemical fcience was cultivated : it was in Holland and in Germany however that it was carried to the moll extravagant pitch. While one phy- fician was earneftly employed in changing the acid Hate of the blood, another took great pains to counteract the alkaline properties of'the fame fluid. While Bontekoe, deducing all morbid phenomena from the vifeidity of fluids, eulogized the medical properties of tea, and drenched his patients with fifty cups in fucceflion of that liquor ; Van Ruftingh preferibed afliduoully large quan¬ tities of volatilefalts in the moll inflammatory complaints ; believing that the two elements of fire and water compofed the fubltance of all living bodies, and that to rellore their balance of power or equilibrium was the only pro- pofitum of the medical art. In our own country the more moderate of thefe tenets, with fome degree of modification, acquired celebrity. Willis, Flower, and others, adopted them, and, multi¬ plying on the acid and alkaline humours of Sylvius, af- ferted the exiftence of a great many different humours, viz, mucilaginous, vitriolic, corroiive, See. each of which they thought had the effeCt of producing a diforder J'ui generis : and hence they endeavoured to trace the various characters of difeafe. The phenomena of fever they like- wife attempted to explain according to the chemical laws of fermentation and ebullition. And, though Willis probably ufed thefe terms merely in an analogical fenfe, yet many phyficians of his time applied them to the human frame in their llriCl and chemical fignification. With refpeCt to the precife mode by which thefe aCiions were thought to bring about the phenomena of health or difeafe, the following is a brief fummary. Digellion was fuppofed to be carried on by fermentation. If this procefs was too aCtive, or, on the contrary, too weak, improper or tinfermented particles of aliment remained, which, when aflimilated and introduced into the blood, pro¬ duced the fame efteCt on that fluid as certain fubftances called ferments do upon vinous liquors; viz. they pro¬ duced fermentation. Now, viewing the matter in this light, thefe chemical pathologifts defined fever to be a fermentative procefs which nature instituted. for the pur- pofe of throwing off the aforefaid offending humours or cacochymias. If nature fucceeded in performing this talk, health was reflored ; if not, death enfued. Some difeafes were however produced by external caufes; for instance, infectious and contagious diftempers, &c. but then each of thofe diforders was brought about by means of humours, whether derived from the air by means of refpiration, or from aCtual contaCt. It is rather remarkable, that thefe phyficians admitted a third caufe of production of cacochymite, which went to overturn their whole fyltem. They exprefsly Hated, that organic difeafe of any of the vifeera engendered a peccant humour ; hence we naturally infer, that in this cafe the folid or fibrous (IruClure was the firft caufe of difeafe. In Italy, where mechanical fcience had made much progrefs, the chemical doCtrine obtained few fupporters. Indeed, anterior to the period we are treating of, Sanc- torius had, in his expofition of the cutaneous functions, taught phyfiologifts the illuilration which the vital de¬ rived from the confideration of the mechanical laws. He endeavoured to diltinguilh the different alimentary mat¬ ters according to their fpecific gravity, and referred difeafe to an obflruCled Hate of the exhalant fyftem : an opinion, however, which this author carried too far, and which was by no means conducive to his fuccefsful prac¬ tice. Neverthelefs it has been of great importance to his more enlightened fucceffors. Sydenham was born about the year 1624. One of the greateft benefits which he conferred upon the fcience of medicine was that of detaching phyficians from this and other hypothetical fyftems, and of leading them to the only true path, obfervation and experience. He intro¬ duced a great reform into medical pradice. Though not entirely free from the humoral hypothefes which were fo prevalent in his time, yet he took care to lludy na¬ ture with exa&nefs, and he reported her appearances with fidelity, even when oppofed to his own reafonings. Indeed in many parts of his writings he takes occafion to deprecate the practice of his predeceffors, becaufe they not only did not fufficiently remark the minute pheno¬ mena of difeafe, but becaufe they actually mifreprefented thofe phenomena for the purpofe of corroborating their fanciful theories. Nor did Sydenham admit the chemi¬ cal explanation of difeafe which was fo ilrongly infilled on by his contemporaries, and even fucceflors; for he exprefsly ftates, that, although he has no objection to the terms ebullition and fermentation, yet he rather ufes them as illustrating certain morbid proceffes by analogy than in their own commonly-received fenfe : and indeed he quotes fome very judicious arguments tending to dis¬ prove the identity of thofe chemical procefies with dif- eafed actions. This author followed very clofely the Heps of Hippocrates : like him, he was principally intent on obfervingthe minute features of difeafe, and of referring them to their obvious and immediate caufes; like hint, he admitted to a great extent the falutary operation of nature, and the deleterious agency of humours ; and like him too he paid particular attention to atmofphe- rical changes, and the effects of them on the human body. Indeed the chief merit of Sydenham confifted in writing clearly, fully, and from his own individual ob¬ fervation, the hiftory of difeafes. He inveftigated the minuteft changes which occurredin them, whether fpon- taneoufly or from the adtion of remedies, as well as thofe 1 arifing PATHOLOGY, arifing from temper, age, conftitution, or other adven¬ titious circumftances. A fyftem of therapeutics founded on fuch a bafis could fcarcely deviate from the right path; and accordingly the works of this author remain molt important ftudies, whether regarded as indications to the art of diagnofis, or to the cure of difeafe. His pradtice was in the molt eminent degree fuccefsful ; and among the remedies he had recourfe to we may remark many which are again firmly eltablifhed after having long fallen into difcredit under the inaufpicious influence of fpeculative theorifts. Among thefe, the ufe of bleeding, and other antiphlo- giftic methods, in the treatment of continued eruptive fevers, has conduced very materially to the prefervation of the lives of our fpecies. We may remark, that in this aflumption we are borne out by the fatality which oc¬ curred during the exhibition of alexipharmics and hot cordials by the chemifts, which the cooling fyftem has very much obviated. The dodlrines of Sydenham, not- withftanding the interefting ftyle in which they were written, the fame they acquired for their author, and their confonance with nature, were by no means gene¬ rally received ; and the chemical dodtrines continued to be advocated by many till the commencement of the fol¬ lowing century. In proportion as true chemical fcience advanced, the partiality for chemical explications of the functions of the living fyftem abated ; and phyficians feem to have difcovered, for the firft time, that the theory of the hu¬ mours, even with all the improvements which it derived from the corpufcular philolophy, threw no light whatever on the adtions of the folids. A new hypothefis, there¬ fore, was projedted; and, as men in avoiding one error are apt to run into the oppoiite extreme, phyfiologifts now attempted to explain all the phenomena of life ac¬ cording to the mere mechanical powers of the organs, and to reduce the laws of the animal economy to the rigid calculations of geometry. They imagined, that they could illuftrate every operation of the human body, by comparing it to a fyftem of ropes, levers, and pulleys, limited with a number of rigid tubes of different lengths and diameters, containing fluids, which, from variations in the impelling caufes, moved with different degrees of velocity. When the fibres of this machine were not fufficiently flexible ; when the pulleys and joints of the levers were not kept in fufficient repair ; or when the apertures of the pipes were not fufficiently free ; the movements were neceffarily fufpended, or lefs perfedlly performed ; and they were only to be brought into pro¬ per regulation, according to the pradtitioners who adopted this fanciful theory, by removing the above-defcribed impediments. The cotnpofition of the fluids was fup- poled to be the refult of their motion in the tubes ; and in thefe nothing was attended to but the forces of gra¬ vity and cohefion ; as in calculating the adtion of a pump, or other hydraulic engine. “ If the chemical fchool,” to ufe the words of Sprengel, “ had degraded the phyfician to the rank of a brewer or diftiller, the difciples of the iatro-mechanical fchool, on the other hand, were glad to be efteemed as hydraulic engineers; and feveral of them, in fadt, ferved in the double capa¬ city of engineers and profeffors of medicine.” One of them, Dionis, a profeuor of furgery at the Jardin du Roi, went fo far as to compare the circulatory fyftem to the water-works at Marly, by which the water of the Seine is raifed to confiderable height, and from thence made to fall again upon the great wheel. Among the caufes which conduced to the eftablifliment of this fedt, the difcovery of the circulation of the blood is the moft prominent. When it was found that the blood flowed in a regular manner, through certain con¬ duits, from the heart, and returned to that organ, by other veffels, from the extremities, phyficians fet about calculating the mechanical force which they luppofed ne- ceffary for enabling the heart and arteries to produce this effedl ; and, elated with their apparent fuccefs, were led by degrees to transfer their calculations to the other fundtions of the body. Geometry had become the pre¬ vailing ftudy of the learned ; and focieties for the pro¬ motion of experimental philofophy were eftablifhed in the different countries of Europe, among which the Florentine Academy del Cimento took, in fome meafure, the lead. It was in Italy that mathematics had been moft afliduoufly cultivated ; and it was there that the firft attempt was made to introduce them into medicine. In the year 1614, Sandtorius publifhed his Medicina Sta¬ tical in which heendeavoured to (how the great influence which the infenfible perfpiration has upon health, and to calculate with precifion all the variations in its quan¬ tity, in the different conditions of the body. According to Iris theory, difeafes originated from the noxious par¬ ticles of the food being retained in the fyftem, in con- fequence of the ftoppage of the tranfpiration ; and, till the latter fundtion was reftored to the proper ftandard, no cure could well take place. Sandtorius diftinguiffied the different alimentary matters according to their fpe- cific gravities, and according as they appeared more or lefs fitted to pafs off in the way of infenfible perfpiration. He even ventured to apply his maxims to the paflions of the mind ; fhowing how joy and equanimity favoured the . excretions, while forrow and fear impeded them ; how fevers and melancholy arofe from the obftrudted perfpi- rable matter, where grief was long continued ; and how they were to be removed by reftoring the fufpended ex¬ halation. Among the aphorifms of Sandtorius, there are many found obfervations ; and medical fcience is under confiderable obligations to him for having diredted the attention of phyfiologifts to the fundtions of the fkin, which, till then, had been in a great meafure overlooked ; but his views, like thofe of moft theorilts, were far too partial ; and there can be little doubt that, in one re- fpect, they had a moft injurious influence, viz. by en¬ couraging phyficians in the univerfal employment of fu- dorifics, to which they were already too prone ; and no one will now fubfcribe to the judgment of Boerhaave, who fays of Sandtorius and his work, “ Nullus medicorum, qui ante eum fcripferunt; cardinem rei ita adtigit ; nec ullus liber in re medica ad earn perfedtionem fcriptus eft.” The mechanical philofophers began by calculating the force of the contradtile power of the heart neceffaVy to produce the phenomenon of circulation : but in this cal¬ culation they proceeded on the erroneous datum, that the refiftance oppofed by cohefion and gravity was the fame in living veflels as in inanimate pipes. Even if this fuppofition had been true, yet they had no means of meafuring the numerous diameters of thefe veflels, their curves, angles, &c. circumftances indifpenfably necef- fary to be known before the above-mentioned calculation could have been made. A more ingenious mode of il- luftrating the procefs of circulation was that adopted by Borelli. This author affumed that the power of a mufcle was in diredl ratio to the fize of fibrous portion : - hence, taking the deltoid mufcle for an example, and having found the force that mufcle was capable of exerting, he next proceeded to calculate the force which the contrac¬ tion of the heart mult exert according to its proportion - ably larger fize. This aflumption, however, is unfounded; for exercife increafes the power of a mufcle, without, in every inftance, increafing its fize: nor does it appear by what means he could precifely infulate tire adtion of the deltoid mufcle, feeing that it is infeparably con¬ joined with feveral others which co-operate with its mo¬ tions. The experiments of Kiel and others, though founded on different aflumptions, were not more fatis- fadtory than thofe of Borelli. At this period, however, geometry was fuch a favourite purfuit among the learned, that its cultivation rendered the mind almoft diffatisfied with every theory which did not bear the teft of mathe¬ matical demonftration. Thefe calculations therefore, to 33 P A T II O L O G Y. to which we muil allow the merit of ingenuity, became generally received. Mechanical principles were applied to every function of the body: not only the motion of the blood, but the compofition of that fluid, and the va¬ rious and elaborate precedes of nutrition, fecretion, &c. were referred to the fame laws. Thisabfurd application of mathematical knowledge to vital phenomena, led thefe philofophers into a labyrinth of error aftonifhing to com¬ mon fenfe. For inftance, while one author calculated the contractile power of the femoral artery at upwards of 1000 pounds, he overlooked the very obvious circum- ftance, that the pulfation of that vedel may be immedi¬ ately fufpended by the ufe of a tourniquet which fcarcely exerts the predure of a few pounds. Indeed, the con¬ tradictory refults arrived at by thefe experimenters (howed the abfurdity of their experiments. Thus, Borelli af- ferted that the contraction of the heart was equal to a refiftance of 180,000 pounds ; Keil, that it was equal to five, or, at molt, eight ounces. Hecquet calculated the digeltive (or, ac, cording to him, triturative) powers- of the Itomach, in conjunction with the abdominal mufcles, to be equal to 261,000 pounds ; Altruc ftated the amount of that power at four pounds three ounces. Yet was this mode of inveftigating the fcience of life by no means ufelefs ; for, by teaching pathologifts to re¬ fort frequently to experiment in proof of their afi'ertions, it deftroyed the attachment to fanciful and gratuitous hypothefis which had fo long prevailed : it directed their attention to parts and aCtions of the animal economy which the humoral phyficians had paded over unnoticed and undeferibed ; and, what was of ftill more impor¬ tance, it induced correCt and analytical habits of reafon- ing. Accordingly, we find, during the 17th century, which may be confidered as the period at which the me¬ chanical philofophers principally flourilhed, difeoveries which have flood the teft of time, and theories, concern¬ ing the correCtnefs of which we are ftill earneftly em¬ ployed in difeuflion. Phyfiology and the minute parts of anatomy were inveftigated with the grandeft refults ; the circulatory fyftem was gradually and fuccefsfully il- luftrated by many diftinguifhed phyfiologifts. Excellent deferiptions of the ItruCture and relative pofition of the heart were given by Steno and Lower. The microfcopi- cai experiments of Leeuwenhoek and others ferved to eftablifh the important faCl of the continuation of arte¬ ries and veins with each other. Ruyfch likewife, by the great degree of nicety in the ufe of injections to w hich he attained, was enabled to throw much light on this fub- jeCl. Some important parts of the arterial fyftem were difeovered by VieulTens. The necefiity of the abforption .of oxygen gas through the lungs was firft inculcated by Mayow. Malpighi improved the knowledge of the ftruc- ture of thofe organs. The mechanical part of refpiration, the compound ac¬ tions of the mufcles, See. were beautifully demonftrated by Borelli; and Kepler applied mechanical principles to the explanation of the functions of the eye in a manner the moft clear and fatisfaCtory. He firft pointed out the true ufe of the cryftalline lens, and fhowed how the images of external objects are formed, in an inverted po¬ fition, on the retina. A public experiment with the eye of an ox, which was made at Rome, in 1625, by the Je- fuit Scheiner, fully confirmed Kepler’s theory: but af¬ terwards Mariotte, having found that the images of ob¬ jects difappeared when they fell on the fpot where the optic nerve enters the eye, called in queftion the fenfibi- lity of the retina, and maintained that the choroid coat was better calculated to receive and rranfmit the percep¬ tions of fight; and a controverfy arofe concerning the aCtual feat of vifion, which was carried on, with great eagernefs, by Pecquet, Perrault, and St. Yves, and which had the effeCt of eliciting many valuable obferva- tions. The Newtonian difeoveries, refpeCting the pro¬ perties of light, contributed ftill more to the accurate analyfis of the functions of the eye ; and the treatifes of Vol. XIX. No. 1285. Du Petit, Porterfield, and Zinn, which followed foon after, have left little for their fuccefiors to accomplifh. The lymphatic fyftem was likewife brought into notice during this century. To Cafpar Afellius is due the merit of having taken the firft ftep in the inveftigation of this important part of the animal frame. While diffeCl- ing a dog, for the purpofe of demonftrating the recur¬ rent nerves, the appearance of a milk-like fluid iffuing from fome fmall white veflels arrefted his attention. Examining them more minutely, he traced them to the villous coat of the inteftines; and repeated difleClions informed him, that thefe veflels -were only obfervable in the animal which had lately fed. Hence he concluded thefe to be the vafa chylifera. He confefled, however, that thefe veflels had been mentioned by ancient au¬ thors, though deferibed in a very imperfeCl manner; but he juftly claimed the honour of having firft pointed out their ufe. Afellius, however, entertained erroneous ideas as to the termination of the ladeals : he fup- pofed that they united together in the pancreas, and pafled from that gland into the liver. This error was corroded by the rel’earches of Pugent, who, obferving on one occafion a milky fluid in the vena cava of a dog, traced carefully the progrefs of that veflel, and difeovered the thoracic duCt. This difeovery was difputed however with much acrimony ; and the character of Harvey was tarniflied by the circumftance, that he flood forth among the moft illiberal of its opponents. The abforbents of the large inteftines were difeovered by Olaus Rudbeck in the year 1651 ; he likewife refuted the received opi¬ nion, that the liver poflefled laCteals, and, by their means, aflimilating powers : he fhowed that the only ab- forbent veflels exifting which could have led to this error, were the lymphatics of the hepatic glands. The glandular fyftem in general was afterwards more fully illuftrated by the writings of Gliifon and Wharton, the experiments of Lower, Drelincourt, Lifter, and Mufgrave; and the anatomical refearches of Nuck, Pacchioni, and Duverney. Nor were the more abftrufe and difficult queftions of phyfiology negleCted by the philofophers of this age. With much talent Willis fupported the hypothefis of a nervous fluid, the vehicle of animal fpirits ; and, when deficient or exceffive, the caufe of diforder ; and he feems in fome refpeCts to have anticipated the fpeculations of Spurzheim and Gall, in referring to particular parts of the brain peculiar mental faculties. The errors of this author on the former fubjeCl were pointed out by Mal¬ pighi, who moreover inveftigated the cerebral ftruClure with great minutenefs, particularly in reference to tire exiftenceof fibres in the cortical fubftance. Here too the injections of Ruyfch and the microfcopical experiments of Leeuwenhoek were ufefully employed to fliow the vaf- cularity of the brain. Many improved deferiptions were furniflied by Cafferius, Duverney, Riverius, Vieuflens, and others, of the ftruClure of the ear. The tunica arachnoides was deferibed by Swammerdam and Blaes. Many interefting experiments were made on the genera¬ tion of animals ; among which the moft famous, though certainly not the moft ufeful, was that of Leeuwenhoek on the animalculae of the feminal fluid. See our article Animalcule, vol. i. p. 727. To the “ triumviate,” as they have been called, Stahl, Hoffman, and Boerhaave, pathology and therapeutics are indebted for many important illuftrations. The firft of thefe phyficians has rendered himfelf famous by the in¬ troduction of an hypothefis, which, with various altera¬ tions, has maintained its ground until the prefent day. We allude to the exiltence of an immaterial principle, or effence, as producing the phenomena of life. The particu¬ lar tenets, however, on which this theory was founded, had been promulgated before the time of Stahl : Rene des Cartes had taught his followers to conlider matter as purely paflive, and to refer all the changes to which it is fubjeCted to a fpiritual caufe : the union of body and K fpirit 34 PATHOLOGY, fpirit was, in his eftimation, merely one of its modes, or accidental conditions. Malebranche, extending the Cartefian dodlrine, endeavoured to explain more fully the nature of this union, and to fliow that the foul had a more or lefs diftindl confcioufnefs of all the movements and affedlions of the body. From thefe tenets, the tran- fition to the fyftem developed by Stahl was very eafy ; and an attentive review of the progrefs of the opinions in queftion mud: convince every one that the Stahlian hypo¬ thecs, far from being entitled to the merit of originality which its author claimed, was nothing more than an off- fpring of the Cartefian philofophy. Educated under Wedel, who was a devoted adherent of Sylvius, and an affiduous teacher of his do£lrines, Stahl began very early to queftion the fufficiency of thofe chemical explanations which he heard applied to all the phenomena of life. It appeared very wonderful to him, that the humours of the body, which are, of themfelves, fo difpofed to putre¬ faction, fliould yet fo feldom fall into that ftate ; and that the daily prefence of fo many faline fubftances, as we are in the habit of receiving in our food, fhould produce fo few fymptoms of acrimony. The intervention of animal /pints he conceived to be a very unfatisfa&ory fuppofi- tion; and all the attempts which had been made to ex¬ plain the theory of life on pure chemical and mechanical principles he held very cheap. Taking the paffivenefs of matter for the balls of his fyftem, he maintained, “ that the body, as body, had no power to move itfelf, but was put in motion only by immaterial fubftances ; that all motion, therefore, was immaterial, and a fpiritual aCt.” It had been alw'ays obferved, that there is a certain power in the animal body of refilling injuries, and correcting fome of its diforders ; and Van Helmont had afcribed fome degree of intelligence to this power : but it w'as referved for Stahl to refer it entirely to the rational foul, which, he affirmed, not only originally formed the body, but is the foie caufe of all its motions, not excepting di- geftion, affimilation, and fecretion, in the conftant excite¬ ment of wdiich life confifts. While he referred to this principle the actions by which health is eftablilhed, he attributed to its irregularity the occurrence of difeafe; admitting however, to a very great extent, the operation of flighter caufes, among which plethora held a favoured rank. To this ftate Stahl fuppofed the human frame was perpetually difpofed, and that at particular periods of life this difpofition manifefted itfelf with great precilion in different parts of the body. Hence arofe, according to him, in infancy complaints of the head, during adolef- cence in the pulmonary ftruCtures, and in old age in the digeftive organs. Fever he defcribed as an autocratic ef¬ fort of nature to conquer the morbific caufe, and to expel it from the body ; and all the fymptoms, not excepting rigor, were only fo many proofs of the tonic aCtion which was thus excited. Congeftions were fuppofed, in con- tradiftindlion to obftrudlions, to refult from an afflux of the fluids occafioned by the fame tonic power; when ob- ftruftion followed, or when the objeCt of the congeftion, i. e. evacuation, w as not accompliffied, inflammation took place; and the tendency of the violent actions which ac¬ companied it, wras to difperfe the obltrufted humour. If this end was not attained, the obftrufted matter be¬ came vitiated, and pus was formed. Hypochondriafis, gout, melancholy, and almoft all cachectic diforders, were attributed to a diminution of the tonic power of the vena portae, and the confequent ftoppage of the blood in it ; while fpafmodic difeafes were thought to indicate an excefs of the general tonic power of the fyftem. Rejecting the aids derivable from anatomical refearches, of the ufe of which in medicine Stahl entertained a very mean opinion, he proceeded, in conformity to the general principles we have related, to the treatment of difeafe. It may very naturally be fuppofed that a theory which attributed (o much to the falutary operations of nature, was not likely to lead to very active practice : accord¬ ingly we find that Stahl adopted, to a very great extent. the Hippocratic mode of watching thefe healing opera¬ tions, without interfering with them farther than to affift their weaknefs or moderate their excefs: and, in fact, he and his followers, trailing principally to the operations of nature, zealoufiy oppofed the ufe of fome of the moil efficacious remedies, as opium, cinchona, and mercury ; and were extremely referved in the employment of bleed¬ ing, vomiting, See. Notwithftanding, however, the hy¬ pothetical notions of Stahl, his inert practice, and Iris con¬ tempt for anatomical refearch, yet much praife is due to him for having directed the attention of pathologifts to the phenomena of vitality, and firowing the fallacy of the chemical hypothefes, a talk for which he was pre-emi¬ nently qualified by his profound inveftigations in tire fcience of chemiftry. Hoffman was a phyfician who obtained great celebrity at this period, lefs however on account of his fuperior mental faculties than for his extenfive erudition, and the art he had of difplaying it to advantage. He was edu¬ cated under the mechanical fed of phyiicians ; and it is rather remarkable, that Stahl, who had been taught the chemical doctrines, fhould have difearded entirely chemi¬ cal illuftrations of difeafe, while Hoffman, who had been taught by the mechanifts, admitted the exiftence of acid cacochymite, and even attempted to fliow how the union of this acid with blood produced neutral files which were the caufe of gout, calculi, rheumatifm, and cutaneous difeafes. Though engaged at one period of his life in controverting the opinions of Stahl, on the fuppofed ground of their atheiftical tendency, yet the theory of Hoffman, as far as the vital or motive principle was con¬ cerned, fcarcely differed from that of his enlightened colleague: for, though he applied to it the appellation of nervous fluid, or ether, and fixed its feat in the nervous fyftem ; yet, in attributing to it the faculties of mind, fenfe, and intelligence, he cauled it to approach very nearly to the anima, or foul, of Stahl. Like Stahl, too, he allowed that morbid aCtions were frequently induced by a plethoric ftate of the fyftem; and, in conformity likewife with the views of that author, he referred much to the obftrudlions of the humours, efpecially in the vena portae. Fever and inflammation he fuppofed to arife from fpafm, or conftridlion of the capillary veffels, particularly of the fkin, an opinion which was illuflrated and im¬ proved in after-times, and more fully developed in the famous theories of Cullen. In the practical department of the art, however, Hoff¬ man left Stahl far behind him. We have to obferve in his treatment of inflammatory diforders great decifion and corredtnefs, and confequently a great degree of fuc- cefs. He aboliflied too, in a great meafure, the fudorific plan of treatment which the humoral pathologifts had pradtifed to a very dangerous extent, and to which Stahl was particularly attached. To him likewife we are in¬ debted for the ufe of the Liquor anodynus, an excellent and well-known article of the materia medica. • He like¬ wife fhowed the great ufe of bark in intermittent fevers, and of chalybeates in chronic diforders. Moreover he in- veftigated, with great care, the -compofition of mineral waters, and taught the a<5l of preparing them artificially. We ought not to forget to remark that, in the work of Hoffman, “ De Confenfu patium nervofarum,” many va¬ luable obfervations will be found, particularly thofe which regard the influence which various organs exert upon one another. But the phyfician who obtained at this period the higheft rank as a pathologill was Boerhaave. Educated by his father with a view to the miniftry, he imbibed at an early age a knowledge of the learned languages ; af¬ terwards applying himfelf with affiduity to the Itudy of mathematics, and then to the profound inveftigations of moral philofophy, he next proceeded to botany and na¬ tural hiftory, by which he laid the foundation for a very extenfive acquaintance with the fcience of medicine, which at length he adopted for his profeffion. See Boer- I HAAVE, •35 PATHOLOGY. haave, vol.iii. Anatomy (of which his works. betray great deficiency) was the only branch of his education which feems to have been negie&ed ; which is neverthelefs fur- prifing, becaufe he differed forfome time underNuck, an anatomift of much repute. Boerhaave conceived that that theory of medicine rauft be the belt which reconciled- the opinions of allfefts; and, accordingly, he laboured to unite the chemical doftrines of the day with the valuable obfervations derived from the other fchools and from Hippocrates. Of the father of medicine he profefi'ed to be a great admirer, and affe&ed to return to the good and ancient method of acquiring knowledge by obferva- tion and experiment; but unfortunately forgot his own rules, yielded to the influence of early ftudies and a love of theorifing, and in many inftances obfcured the fcience his abilities had otherwife enabled him to adorn in a moft eminent degree. However, the plaufibiliiy of Boerhaave’s dodtrines, the beauty of his ftyle, and the graces of his delivery, gained for him an afcendancy which is almoft unparalleled. We may form fonte idea of the importance attached to his labours when vve read, that, on his beginning a courfe of le&ures, the occur¬ rence was deemed of fo much confequence, that the whole city was illuminated. Boerhaave adopted a notion, of which his philofophical education (hould have taught Jiim the abfurdity ; viz. the exiftence of an intermediate Jubilance between matter and fpirit, a principle which regulated or produced all the vital functions. He had taken this idea from an ancient dogma found in one of the writings attributed to Hippocrates; and his nephew, Kaan Boerhaave, followed up and illuftrated this hypo¬ thecs with much fpirit, and, unfortunately, with the ad¬ miration of his contemporaries, who adopted it almoft: univerfally, until the fplendid dilcourfes of Haller began to wean them from opinions fo diflonant to the refults of found reafoning. Boerhaave died in the year 1738 ; fo that we have now fairly got into the eighteenth century, and have arrived at a period when phyliology, long obfcured by the mifap- plication of the natural fciences, at length began to be fludied according to the dictates of found reafoning and the refults of experiment. The name of Haller (who ftudied under Boerhaave) (lands in lofty pre-eminence among the cultivators of medical fcience during this cen¬ tury. Panegyric has been feldom more properly applied than to this diftinguiflied author. His biographers have (hown how afliduoufly, at the earlieit periods of his life, his mind was bent on the acquilition of knowledge ; and they have reported his varied, his extenfive, accompii(h- ments. His poem of the Alps (hows how eminently he poflefled fublimity of imagination and the harmony of numbers; and his refearches in our own fcience manifeft the profundity of his reafoning; while the admirable picture is clofed by the relation of his earned regard for the intereds of morality and^religion. In a word, Haller feems to have almod realized the account given of the gods, or inventors of medicine, who individually united the four grand fciences of- poetry, legiflature, phyfic, and divinity. See the article Haller, vol. ix. The irritability of the body was the point to the efta- blifhment of which a very large proportion of Haller’s refearches were diredted ; and in this principle he formed a ready folution of many phenomena which had puzzled his predeceffors and given rife to much idle and fanciful fpeculation. We may be excufed, however, from en¬ tering into the phyfiological difcoveries of Haller, as we (hall have cccaflon to treat of them fomewhat largely in our article Physiology. It (hould be mentioned, how'- ever, that the Elementa phyjiologice of Haller is a work of thegreated merit, and which, notwithftanding the won¬ derful progrefs of phyfiology in our own time, may dill be referred to, as containing an immenfe body of refearch arranged in a very beautiful manner. And this book would probably have dill remained the text-book of every phyfiological fchool, had not the profound re¬ fearches of our countryman Hunter led mankind to de¬ tect its errors and deficiencies, and (hown how much dill remained to be done ere the fabric of this fcience could be confidered as reding on a ftable foundation. It would appear that Haller was not an operating fur- geo n ; for, in- h Js Bibliotheca Chirurgica, vol. ii. he fays, as conliftent and rational in his treatment of difeafe, which cannot be accorded to either of the latter. He likewife made an arrangement of difeafes which had great merit, and which nothing but the increafe of phyliological know¬ ledge, and its fuccefsful application to pathology, that has taken place in our time, can warrant us in departing from, and which indeed we promifed to adopt. See vol. xvii. p. 245. Cullen’s pathological doctrines were a modification of the theory of Hoffman. From that author he took up the dodtrines of l'pafm and debility, and deduced from them all the phenomena of febrile diforders; and he en¬ deavoured to confirm his theory by proofs drawn from the laws of the nervous fyftem, and from the confidera¬ tion of the remote caufes of the difeafes in queftion. Rheumatifm was referred by him to a fpafm of the muf¬ cular fibres, arifing from an increafed afflux of blood; but gout he conceived to originate in atony, efpecialiy in atony of the digeftive organs. In thefe latter difeafes, he rejected the idea of a peculiar morbific matter; yet in his explanations of certain other complaints, as, for inftance, of fcrofula, he had recourfe to the fuppofitiou of an acrimony of the fluids. He laid much ftrefs on the efforts of the vis medlcatrix nature, advocated the hypo- thefisor a nervous fluid and vital principle, and aferibed to the brain a peculiar faculty, by which it was enabled to excite the mufcles to adlion, independently of the mind, and to which he gave the name of irritability of the fenj'orium. Cullen feems to have been much in the fame fituation with Boerhaave as to anatomical and phyliological 40 PATHOLOGY. phyfiological learning, of which many of his fpeculations betray a fad deficiency. In regard to fever, Dr. Cullen’s theory was that the firft change induced in the animal fyftem by the opera¬ tion of the exciting caufes of fever is, “ diminution of the energy of the brain.” The powers of the body and the mind, the functions of fenfation and motion, refpi- ration, circulation, and fecretion, all fail, or are dimi- niflied in the general debility ; but, after a certain time, a morbid increafe of fome of thefe funftions, efpecially of the circulation, takes place, with an augmentation of the heat. The three Hates of debility, of cold, and of heat, which regularly fucceed each other in fever, in the order juft mentioned, are prefumed to exift in the rela¬ tion of caufe and effedt ; the firft ftate being the refult of the fedative or debilitating influence of contagion, rnarfh- miafmata, and cold, which are the exciting caufes. Dr. Cullen acknowledges his inability to explain fatisfadlo- rily, how the debility produces all the phenomena of the cold ftage, efpecially the Jpafmodic conllridtion of the extreme arterial veflels, which is inferred from the luf- penfion of the fecretions, and the flirinking of parts, in the cold ftage, as well as from the continuance of this fufpenfion in the hot ftage, after the aftion of the heart and large arteries is increafed. Were the conftridHon of the cold ftage merely the refult of the weakened adfion of the heart, it is fuppofed, that, on the return of its ordinary or increafed adtion, the conftridfion would be removed, and the fecretions reftored. Here Dr. Cullen reforts to “ the vis medicatrix nature, fo famous in the fchools of phyfic i. e. the innate preferving power of the conftitution, which has been appealed to for the fo- Jution of difficulties by all medical theorifts, from Hip¬ pocrates downwards. This “ fpafm of the extreme vef- fels,” then, is confidered as “ a part of the operation of the vis medicatrix naturae j” at the fame time, Dr. Cullen is of opinion that, during the whole courfe of fever, there is an atony exifting in the extreme veflels, depend¬ ing on the diminifhed energy of the brain, and that the relaxation of the fpafm requires the reftoration of the tone and adtion of thefe. To this atony in the veflels of the fkin, he attributes the lofs of appetite, naufea, and vomiting, the ftomach being affedted by fympathy. The fpafm induced in the extreme veflels throws a load of blood upon the central parts of the circulating fyftem, which proves a fource of irritation to the heart and ar¬ teries, and excites them to a greater adtion, which con¬ tinues till the fpafm is relaxed or overcome. The hy- pothefis is thus briefly recapitulated : “ Upon the whole, our dodlrine of fever is explicitly this. The remote caufes are certain fedative powers applied to the nervous fyftem, which, diminiftiing the energy of the brain, thereby produce a debility in the whole of the fundlions, and particularly in the adtion of the extreme veflels. Such, however, is, at the fame time, the nature of the animal economy, that this debility proves an indiredt ftimulus to the fanguiferous fyftem ; whence, by the in¬ tervention of the cold ftage, and fpafm connedted with it, the adtion of the heart and large arteries is increafed, and continues fo till it has had the effedt of reftoring the energy of the brain, of extending this energy to the ex¬ treme veflels, of reftoring therefore their adtion, and thereby efpecially removing the fpafm affedting them ; upon the removing of which, the excretion of fweat, and other marks of the relaxation of excretories, take place.” Cullen’s Firft Lines, § 46. To this theory it has been objedted, firftly, that it is founded, as far as regards the vis medicatrix natures, on the gratuitous affumption that a principle exifts of which we have fenfible evidence ; fecondly, that, to take the cold ftage as the proximate caufe of the after-phenomena of fever, is difl'onant with evident fact ; for the hot ftage of fever often comes on apparently from external caufes, and unaccompanied by the cold ftage; and thirdly, that, with regard to fpafm of the external veflels, 1'uch an oc¬ currence affords no explanation of febrile phenomena ; and indeed it feems quite abfurd to fuppofe that the hot ftage and the cold ftage can by any means be confequences of the fame adfion ; and that, fo far from the capillaries being contradfed, we have pretty clear evidence tha"t they are extremely diftended with blood during all febrile difeafes in which the fkin is affedted. In a paflage of his “ Inftitutions of Phyfiology,” Cullen fpeaks of a ftate of excitement, or collapfe, of the brain and nervous fyftem, on which he fuppofes the ftrength or debility of the other parts of the body to depend ; and in his other writings, he is constantly labouring to prove ill what manner thefe conditions may be occafioned by the agency of various caufes. Brorcn, feizing upon this idea, let about the formation of a new theory, according to which all the adtions of life were to be referred to the excitement of the body by Jlimuli, and all difeafes reduced to the two general heads of diredl and indiredl debility, or debility ariling from a deficiency, or a previous exoefs, of excitement j or in other words into fthenic and afthe- nic diforders. The Brunonian fyftem might very well be compared with the Methodic, its diftinguilhing features being the referring of all difeafes to two oppofite conditions of the conftitution, Jlhenia and ajlhenia, or ftrength and debility, which might with almoft equal propriety have been called Jlridlum and laxum, (fee p. 11.) and the confequent ex- clufion of all particular inveftigation of the minute dif- tindtions in the phenomena of difeafes which it encou¬ raged. This fweeping arrangement was, however, much lauded in many parts of the continent, and gained a very large proportion of advocates in our country, among thofe who had not fufficient knowledge of nature to de- tedt its fallacy. The molt general of Brown’s principles are thus explained. 1. To every animated being is allotted a certain portion only of the quality or principle on which the phenomena of life depend. This principle is denominated excit- ability. 2. The excitability varies in different animals, and in the fame animal at different times. As it is more in- tenfe, the animal is more vivacious or more fufceptible of the adfion of exciting powers. 5. Exciting powers may be referred to two clafles. 1. External; as heat, food, wine, poifons, contagions, the blood, fecreted fluids, and air. 2. Internal; as the functions of the body itfelf, mufcular exertion, thinking, emotion, and paflion. 4. Life is a forced ftate ; if the exciting powers are withdrawn, death enfues as certainly as when the excit¬ ability is gone. 5. The excitement may be too great, too fmall, or in juft meafure. 6. By too great excitement, weaknefs is induced, becaufe the excitability becomes defective ; this is indi¬ rect debility : when the exciting powers of ftimulants are withheld, weaknefs is induced; and this is diredt debility. Here the excitability is in excefs. 7. Every power that adts on the living frame is ftimulant, or produces excitement by expendingexcitability. Thus, although a perfon accuftomed to animal food may grow weak if he lives upon vegetables, ftill the vegetable diet can only be confidered as producing an effedt the fame in kind with animal, though inferior in degree. Whatever powers, therefore, we imagine, and however they vary from fuch as are habitually applied to produce due excitement, they can only weaken the fyftem by urging it into too much motion, or fuffering it to fink into languor. 8. Excitability is feated in the medullary portion of the nerves, and in the mufcles. As foon as it is any¬ where affedted, it is immediately affedted every-where ; nor is the excitement ever increafed in a part, while it is generally diminifhed in the fyftem ; in other words, dif¬ ferent parts can never be in oppofite ftates of excitement. We 41 P A T H We will not detain our readers by detailing all the numerous controverfies in which this theory has engaged the medical world, nor by repeating the various argu¬ ments which oppofed its adoption among the more en¬ lightened of our own phyficians : for an hypothecs which fails to explain all the phenomena of difeafe cannot be confidered worthy of our notice ; and how could it be fuppofed that Brown, who paid little attention to the minute fymptoms of difeafe, was capable of generalizing fadts fo various and anomalous ? In no inftance does the application of thefe principles form fo much a fubjeCt for regret as in regard to the treatment of fever prac- tifed by the followers of Brown. It may be laid, without exaggeration, to have immolated millions of our fellow- creatures. It inculcated methods of treatment the moll oppofite to thofe indicated by nature and common fenfe. Let the ftatiftical reports of mortality in every climate teftify the truth of this painful affertion. To ftimulate in inflammatory diforders is a mean fo repugnant to the feelings of the patient, or the advice of every practical author, from the time of Hippocrates downwards, that we are aftonifhed at the extenfive prevalence of fo ablurd a practice. We fliould remark, however, that the more enlightened of Brown’s followers modified his doCtrines conliderably, and in their practice often departed ef- fentially from his dogmas. In attempting to explain the phenomena of fever according to the doCtrine of direCl and indirect debility, Brown has the following expref- lions : “ The diftinCtions that phyficians have made about the differences of fevers are all without foundation ; they are all the fame, with no other difference but in de¬ gree ; and, unlefs in that refpeCt, they do not differ from other difeafes of the fame form.” Elements of Medicine, § 662. note m. He does not, however, attempt to ex¬ plain the manner in which the various fucceffion of fymp¬ toms refults from the ftate of debility, or how the various modifications of the pyrexiae are to be accounted for upon this principle. The only approximation to fuch an explanation, is merely an enumeraiion of the leading changes in the fymptoms after the manner of Cullen, but lefs explicit than the one given by that author. We are told, that “ the debility during the cold ftage is the greateft ; that of the hot lefs ; and that of the fweating ftage, wdiich ends in health for the time, is the leaft of all. Hence, in a mild degree of the difeafe, as cold is the moft hurtful power, its effeCt is gradually taken oft'by the agreeable heat of the bed or of the fun, and the ftrength thereby gradually drawn forth. The heart and arteries, gradually excited by the heat, acquire vigour, and, at laft, having their perfpiratory terminations excited by the fame ftimulus, the moft hurtful lymptom is thereby re¬ moved, the hot fit produced, and afterwards the fame procefs carried on to the breaking out of fweat.” § 666. We are farther told, that “ the caufe of all thefe diieafes, (viz. fevers, from the Ample and intermittent to the gaol-fever and the plague,) is the fame with that of dif¬ eafes not febrile, to wit, debility ; differing only in this, that it is the greateff debility compatible with life, and not long compatible with it.” § 670. Such is the vague and inexplicit theory which divided the medical world, which excited fo much intereft in thofe who efpoufed or oppofed it, and infpired fuch a de¬ gree of enthufiafm in the debates and writings efpecially of the pupils of the feminary which gave it birth, that it not unfrequently burft forth with all the violence of re¬ ligious phrenzy. This indeed is little to be wondered at, when we confider that half-educated young men, as is the cafe with the great proportion of medical ftudents, unaccuftomed to patient inveftigation, and fond of no¬ velty, are the moft apt to embrace fuch fpeculations as could be fupportedand defended by ingenious and lubtle reafonings rather than by accurate and extenfiveofe, that the fimultaneous exhibition of agents fo oppo- fite, is a defirable objeCl ? It will, no doubt, be always a tEoft valuable acquifition to the quack, who, not know¬ ing what intention he fhould endeavour to fulfil, may reckon with tolerable certainty, that fome of the articles of this panacea are adapted to the wants of his patient. We cannot too ftrongty reprobate the retention of this compound, which has obvioufly arifen from timidity in the authors, who feared to rejeft a remedy of which fo high an opinion is entertained. B ut by whom? They themfelves anfwe? the queftion, and confefs they have aCted according to the willies of thofe who are totally unqualified to form an opinion. One of the reafons given for its introduction into the new Codex is, “ quia a vulgo fsepius requiritur.” A parity of reafoning would lead them to introduce into their Pharmacopoeia all the quack-medicines of the cornpofition of which they could attain a knowledge ; and, indeed, this inten¬ tion they have difplayed on one or two other occafions. It appears to us, that in afligningthe above caufe for the retention of certain remedies, they have miftaken their duty, which is no lefs to decide what medicines ought to be retained or rejected, than to give accurate inftructions for the compounding and preparing of fuch as are judged proper to compofe a part of their materia medics,. After all the ingredients of the theriaca have -been mixed to¬ gether, fecundum artem, they are fet afide for one year, in order to undergo a flow fermentation, as it is directed in the Codex. That they do not undergo this procefs, teems probable front the circumftance that anal-yfis dif- covei's no difference between parcels of theriaca differing much in age, the recent preparation perfectly re fern biin g that which has been of feveral years Handing; Diafcor- di u 1Y1 is another eleCtuary, tranfiated from the old edi¬ tion to the new Codex, in all its priftine complexity, with the fame fcrupulous regard to its cornpofition as that we have juft been confiderirrg. It is only to be wondered how the Theriaca cceleftrs, and the BenediCta laxativa, each of them confifling of at leaft twenty arti¬ cles, could have fo far degenerated as to have forfeited a place in this new edition. A new preparation of opium has been very recently propofed by Mr. Robiquet of Paris. It has been afeer- tained, that the moft aCtive properties of opium refide in two fubftances, which may be obtained in difcinCl forms, and which produce very different effeCts ; narcotine, and morphine , as they have been named. The former is a very powerful irritant to the nervous fyftem, as appears from the experiments of Dr. Majendie ; and it feems to be this fubftance which produces the effeCts which we fo much wifh to avoid in the adminiftration of this medi¬ cine, and which are obviated, to a certain extent, by giving it in the form of the black drop , or other analo¬ gous acid preparations. Morphine, according to the evi¬ dence of the fame experiments, and others made on hu¬ man beings, produces fedative effeCts without fymptoms of the flighteft irritation. To feparate the narcotine, then, from the other parts of opium, is a very defirable object of pharmacy 5 and Mr. Robiquet fays it maybe eafily effected in the following way : “ I macerate,” fays Mr. Robiquet, “common opium, divided into fmall pieces, in cold water, as if it were for the aqueous ex¬ tract of opium ; I filter the folution, evaporate it to the confiftence of a thick fyrup, and treat it, in convenient veffels, with rectified ether ; the whole is then fhaken a great many times, before the ethereous tinCture is poured off; this, being feparated, is then fubmitted to diftillation, that the ether may be drawn from it. This procefs is repeated as often as cryftals of narcotine are obtained as a refidue of the diftillation. When the ether is without aCtion, I evaporate the folution of opium to a confiftence proper for pills; and I obtain, by this means, an extraCl wholly free from narcotine.” In the Revue medicule, before quoted, there is an arti¬ cle continued from time to time, called “ Medical Let¬ ters.” Thefe contain the medical chit-chat of Paris. From the 2d M° of that work, we fnall make a few ex¬ tracts applicable to our prefent purpofe. Thefe letters contain much truth, but not without a mixture of what the French call malice, a term, however, not of fo harlh a meaning as the fame word in our language ; and will certainly give an idea of the ftate of medicine, and the opinions upon it, at this time. “ Paris has long given the ton to Europe ; and fo com¬ pletely dictates to the provinces, that whatever comes from the capital excites the greateft curiofity ; a feeling the more predominant in medical men, from its having been as yet, with regard to them, lefs gratified. The daily papers detail only events of general intereft ; and the fcientific journals exclude all anecdote. To fill fuch a gap will be a difficult enterprife, and the execution of it will offend many ; but the confideration that fcience and the public will gain by it, is a fufficient incitement to the attempt. “ Petitions have been prefented to both chambers, to proteft againft the fuppreifion of the concours (examina¬ tion and competition) in the election of profeffors ; and one of the petitioners has proved to demonftration, that the only objeCt in this fuppreffion is to ferve the interefts of M. Royer- Collard. If this gentleman had taken the trouble to ftudy chemiftry, anatomy, and medicine, by way of qualifying himfeif to deliver a courfe of medical jurifpruder.ee, there is no doubt but he would have faved government from all the blame which this election has thrown upon it. John Hunter, arriving at the age of twenty-two years from the mountains of Scotland, where he exercifed the trade of a carpenter, became ne- verthelefs one of the firft anatomifts of England. M. Royer- Collard, arriving at Paris at the age of forty from ChambCry, where he performed the duties of a commit- fary, might have found fome better method of teaching medical jurifprudence than by reading leCtures copied from a printed book which is known to the whole world. The 49 PATHOLOGY. The fource from which the profefi’or drew thefe waters of fcience was foon difcovered ; each ftudent, being able to tafte them at the fountain-head for the moderate fum of thirty francs, the price of M. Fodere’s excellent Treatife on Medical Jurifprudence, did not hefitaie be¬ tween this expenfe and the fatigue of lifteningto tedious lectures ; fo that the profefl'or found himfelf abandoned by his pupils, and left alone in the vaft amphitheatre of the fchools of the faculty. Such a milhap is certainly a fufficient apology for M. Royer- Collard’s having given fo few leftures in the firft year of his profefTorfhip, and for having, during the fucceeding years, renounced all public inftruftion. Still-we are indebted to the profelfor for the excellent courfe of leftures which his pupils heard in the fummer of 1819. As direftor of the Bibliotheque Medicale, he infured the fuccefs of the work by contri¬ buting the feweft articles to it; as profelfor of medical jurifprudence he felt it his duty to refort to limilar means to recall his truant pupils, and accomplilhed his objeft by employing M. Orfila to lefture for him ; and the fuc¬ cefs of the experiment did not detradl from the reputa¬ tion of the learned author of the Toxicologie. “ Several nominations followed that of this able che- mift. M. Beclard was called to the chair of anatomy, M. Marjolin to that of external pathology. MM. Fou- quier and Roux have alfo been lately appointed ; the firft to the chair of the Clinique de Perfeftionnement, vacant by the death of M. Bourdier; the latter to a chair of pa¬ thology, vacant by the refignation of M. Percy. A-pro- pos of this refignation ; it is faid in the medical world of Paris, that 60,000 francs was the price M. Percy received for this profelforlhip ; certainly a large fura for a place, the receipts and prefervation of which are not certain. The cafe is not without precedent; at Montpellier in 1786, M. de Barthez fold a profeffor’s chair to M. Gri- maud for 30,000 francs. This is great authority for the venality of profeflorfhips ; which, however, has one little inconvenience, i. e. that of excluding the poor man of talent, though it prefents the inappreciable advantage of narrowing the field of favour, a divinity more to be feared than riches. Still we cannot complain of fimilar bar¬ gains, when they bring fuch men as M. Roux into a more extended fphere of ufefulnefs. This excellent fur- geon and learned profelfor muft always have appeared to advantage in a concurrence with any rivals. “Since the fupprellion of the concours , the faculty of medicine prefents to the choice of the committee of pub¬ lic inftruftion four candidates. The three laft are, how¬ ever, only infcribed for form’s fake. This fort of eleftion is not at all approved by the faculty, who accordingly, in 1818, unanimoully demanded that the vacant profefl'or- ftiips fhould be given by the concours. The committee of public inftruftion refufed to accede to this requeft ; and, to avoid all difcufiion with the faculty, refolved to choofe the firft of the candidates named. It was there¬ fore without any chance of fuccefs, that MM. Hulfon, R6camier, and Parifet, were joined candidates with M. Fouquier. “ You have not forgotten that M. Parifet left Paris, by order of the minilter of the interior, to obferve the yellow fever which raged at Cadiz, with great violence, in the fummer of 1819. In Europe, as well as in the tropics, this difeafe always difappears on the firft ap¬ proach of winter; a little trifling fa ft, of which M. De¬ cazes ought to have been aware before he put the ftate to fuch an expenfe. As M. Parifet was ftill at Madrid on the 23d of November, it is clear that he could not make obfervations on a difeafe which had already difap- peared from Cadiz. The only fubjefts for examination would be convalefcents, who are perhaps as fit to give an idea of the charafter of a difeafe as a few ftragglers to convey an appropriate impreflion of the nature and ftrength of an army. If M. Parifet had departed three months earlier, he might have given us the refult of his Vop. XIX No. 1286. own obfervations ; as it is, we fhall only now have the opinions of the Spanifti phyficians, which could have as well been tranfmitted by the poll. As yet the fruits of fuch an expenfive journey are confined to four co¬ loured engravings, publifhed by M. Parifet, which, an¬ nounced at a moment when all eyes were direfted to Cadiz, excited great curiofity. We expefted at lead portraits of Quiroga, Riego, plans of the fortifications of La Ifla, and the redoubts of La Cortadura. It was a cruel difappointment for the curious to find three faces of men dying of the yellow fever, and fourteen tongues ; not tongues of eloquence and fire, but the dirty tongues of patients announcing to the eye and finger the ftate of the inteftinal canal ; and which are intended by M. Parifet to exprefs the different phafes of the yellow fever in fuccefflon. You will be furprifed at this. Why ? Since w'e clafs and defcribe difeafes by the fame method which botanifts employ to clafs and defcribe plants, it is natural that we fhould endeavour to determine the charafters of the former, by the aid of drawings. M. Parifet, indeed, muft view difeafes as enjoying great ad¬ vantages in this refpeft ; for Linnaeus affirms that the colour of the corolla is too variable a quality to deter¬ mine the diftinftion of vegetables; and our learned traveller confiders the colour of the face and tongue as cbarafteriftic of difeafes, in which the expreflion and co¬ lour of the face change from minute to minute. “ M. Gall has commenced his annual courfe of crn- niology in the amphitheatre in the Rue St. Viftor. This fcience is getting Angularly out of fafhion. Time w'as when M. Gall made us pay high enough for his leftures, and w'e had difficulty to fight our way to the door. Now we enter gratis, and there is plenty of room. When M. Decazes was minifter of police, he greatly encouraged the fcience of craniology, by giving its inventor a penlion of 3000 francs. M. Decazes undoubtedly found the fcience ufeful inchoofing his counfellors ; and, if this minifter’s reign had continued, the late preventive laws would have been founded on craniological principles. “A fubjeft which has more reality and praftical appli¬ cation, is the excellent courfe of human anatomy which M. Beclard gives to the faculty of medicine. M. Dumeril had already greatly advanced the ftudy of this department of anatomy, confidered in a philofophical point of view. Some indeed thought that he too frequently introduced the fubjeft of comparative anatomy. M. Beclard is more referved on this point ; but the compofition and analogies of textures, the forms and relations of parts, both in a ftate of health and difeafe, fuggeft to him at every ftep a variety of interefting general obfervations, w'hich en¬ liven the drynefs of anatomical difcufiion, and are almoft all of praftical application. M. Beclard, before he be¬ came profefl'or, underwent the probationary trials, as “ chef des travaux anatomiques.” MM. Dumeril and Dupuytren occupied this honourable poft before him. M. Brefchet now' fills it in a manner which will foon place him on the diftinguifhed level of his predeceffors. M. Chauffier ftill teaches phyfiology, and gives two leftures a-week. This learned teacher always difplays the fame profound views, and the fame originality of ideas. He ftill preferves his prejudices again ft the acceflary lciences, which he calls “ftrangers to medicine,” and againft che¬ mical explanations of phenomena, w'hich he ftyles chi¬ merical. “Since Profefl'or Cuvier has become a ftatefman, and fcience is only the amufement of his leifure hours, there are no other leftures on comparative anatomy at Paris, but thofe given by M. de Blainville, at the Faculte des Sciences. They are very well attended, and would he more fo if the theatre of the College de Pleffis were larger. M. de Blainville, as a favant and profelfor, promifes to be a worthy fuccefl'or of his mafter Cuvier, wffiom w'e truft he will follow in his Linnsean zeal for the fcience of nature 3 but we hope he will not imitate him in thofe O pretenfions 50 PATHOLOGY. pretenfions to nobility, which made Buflfon ridiculous though born noble; nor that in love of office, which was the misfortune of Pliny the elder, and of which M. Cuvier feems to have his fhare. “ You are acquainted with the work which M. Geoffroy de Saint Hilaire publiffied laft year on philofophical ana¬ tomy, in which he endeavoured to bring all the types of organization to a primitive and unique form. M. Geoffroy continues to illuffrate his dil'coveries at the College de Pleffis before a numerous audience, and de- monftrates that “ infefts ire provided with a fkeleton as complete as that of the large quadrupeds ; that the cruf- tacese do not walk upon their claws, but upon their ribs. It is a pity that man is not a lobffer, for then, like ourfirft father, Adam, we might lofe our ribs with¬ out being aware of it, which would have diminifhed the rifk which M. Richerand ran in removing thole of the unfortunate Michelleau, in his famous operation for cancer. For a long time M. Richerand has publiffied nothing but new editions of his old works : it is matter of regret; for this furgeon has great talents as a writer. The clearnefs of his ffyle is admirable, and his works have been univerfally popular as elementary books. But M. Richerand as author, and M. Richerand as profelfor, are tw'o very different perfons. It appears to be matter of regret that M. Richerand fhould have changed his former chair of external pathology for that of operative medicine. In the latter he had to fucceed M. Dupuytren. Who could ftand the comparifon ? M. Dupuytren is perhaps the only furgeon, who with C. Bell and M. Delpech, has made it his ftudy to teach the art of ope¬ rating by fliowing the relation of different methods with the ftrufture of parts, and by determining the advantage of each proceeding according to the alterations of form produced on organs by difeale. “The leftures on che- miftry are, of all the lectures delivered at the Faculty of Medicine during winter, the beft attended. He who wiffies to know chemiftry thoroughly, muff attend M. Vauquelin. He who wiffies to fee chemical fails philo- fophically arranged and illuftrated by experiments ffiil- fuliy performed, muff go to the College of France, and to the Faculty of Sciences, to hear M. Thenard ; but he muff make hade, for it is as difficult to get a place to hear Thenard as to fee Talma. “A new and rival fchool has rifen by the fide of the Faculty of Medicine. A generous oppofition is already the refult, and it will probably fave the medical fchools of France from the deftruftion which hovers over them. Indeed the fchool of Val-de-Grace can only yet boaft of one profefi’or of celebrity ; but this teacher is endowed with real talent. He has all theenthufiafm of a reformer, and the power of communicating it when necefiary. It is in vain to conceal the influence which M. Brouflais already ex- ercifes, not only on the ftudies of the pupils, but on the' praftice of the phyflcians of the capital. As this influence is the moft important faff I have to communicate at pre- fent refpefting our fcience at Paris, I fiiall take an early opportunity of detailing to you' the doftrines of M. Brouflais. It would not be judging properly of his doc¬ trines or practice to repeat with the public, that the an¬ nual confumption of leeches in the civil hofpitals of Paris, which conllituted only an expenfe of 2000 francs, is now 80,000. (See p. 4.6.) You will neverthelefs have heard that M. Brouflais is not fo much in vogue as laft year, when the minifter at war found it necefiary to clofe the doors of the hofpital to the crowd of ftudents who be- fleged them. As the doftrines of M. Brouflais are of a direft praftical application, the above-mentioned circum- ftance may have retarded their propagation. It does not much lignify. If thele doctrines are true, reflection and time will only ferveto eftablifn them ; if they arefalfe, it is perhaps better that the pupils fhould defer the exami¬ nation of them until they are qualified to judge and think for themfelves. “ There are fome people in the world, doubtlefs, who with to eftabliffi the amount of a falary upon any other confideration than the fervice rendered for it ; but we mult look to a madhoufe only to fee the falary increafein direct proportion to the diminution of attendance. In the hofpital of lunatics at Charenton, the following regula¬ tion appears: “The phyfician fhall refide in the efta- bliffiment ; he fhall receive a falary of 4000 francs, and pay five vifits a w'eek ; if he does not refide, he is to re¬ ceive 6000 francs, and pay only three vifits.” Talking of the Charenton, I rnuft give you an account of a new method of improving the falsifies of phyflcians in hofpi¬ tals where the patients pay for their board. This plan conflfts in affigning to the former a certain fhare, fay two- twelfths, of the favings which are made on the fum the patient pays, rendering it of courl’e the intereft of the phyflcians to make this faving as confiderable as pofiible. The firfary of the phyfician, therefore, it is evident, can only be limited by the bad intentions of a director too much attached to the welfare of the patients. This may be eafily obviated. By the affiftance of calumny, the di¬ rector is got rid of ; and, to prevent all future difputes, the direction of the hofpital is made the marriage-portion of the phyfician’s daughter. I need not tell you that the Lunatic Afylum of Charenton is out of the adminiftrative control of the hofpitals of Paris. “When a man profefles zeal for his profeffion and love for humanity, his ardour in difeharging his duties is above all remuneration. At the Hotel Dieu, M. Dupuytren receives a very moderate falary, which is neither direftly nor inverfely proportioned to the number of his vifits, and which does not prevent his going winter and fu miner to the hofpital from half-paft five in the morn¬ ing to ten, and again returning in the afternoon to fee the patients who have been recently operated upon. Here, a Ifo, M. Dupuytren, before performing an ope¬ ration, eftablifhes, in prefence of a numerous audience, the caufes which indicate it; he difeufles the methods of operating employed by furgeons, and deferibes the one at length which he is about to employ. At the Charite, MM. Boyer and Roux alternately take charge of the clinical department. M. Boyer ex¬ amines the houfe-pupils on the patients entrufted to their care. The profefl’or difeufles the moft important cafes, and difplays all that profound knowledge and practical abi¬ lity which have long ranked him amongft our firft furgeons. At the Hofpice de la Faculte, there are only forty beds, and the patients are feleCted with great care. M. Dubois can therefore devote to each patient a fufficient time to eftabliffi the diagnofis, and anfwer the queftions which each pupil has a right to addrefs to him. In the theatre, the profefl’or enters on the cafes which have been ope¬ rated on, or thofe which are about to take place. The operation is then performed, after which M. Dubois fees the out-patients. Here he applies public inftruftion to private praftice, and prefents us in part with the advan¬ tages of thofe private eftablifhments which in Germany are called clinica ambulatoria. M. Dubois is really inde¬ fatigable ; to the experience of age he joins the ardour of youth. Charged with the inftruftion of female midwives at the Hofpice de la Maternite, he has juft commenced a public courfe of leftures on midwifery for medical ftu¬ dents. Thefe leftures will be quite an epoch, and un¬ fortunately they will be the laft which M. Dubois will give on a lubjeft which requires more to be reduced than extended. Who will be better able than this learned fur¬ geon to reduce to their proper value the pretenfions of thofe furgeons, who haVe only become great accoucheurs becaufe they were not fit for any thing elfe ? “M. Roux has repeated wfith fuccefs the beautiful operation of the future of the velum palati, which he was the firft to praftife, upon an American, who had hqd a congenital divifion of this mufculo-membraneous part. Some months ago, at the Royal Academy of Sciences, the fubjeft of this operation, whofe voice before was hardly perceptible, read his own cafe very diftinftly.” The PATHOLOGY. 51 The following account of the funeral of the celebrated Corvifart, well known to the Englifli faculty by his wri¬ tings, which we extradt from the Journal des Debats of the 22(1 September, 1821, may be thought curious by the mere Englilh reader. “The obfequies of M. le Baron de Corvifart, phyfician, took place to-day. In purfuance of the directions contained in his will, his body was not taken to the church of St. Elizabeth, his parifli, but was conveyed to his eftate at Atys, where he defired that the religious ceremonies Ihould be performed. A deputation from the Faculty of Medicine, in their do&or’s robes, (en habit doSioral,) and nearly all the phyficians of Paris, repaired this morning to his late refidence, Rue de Ven- dome, for the purpofe of attending his funeral. Mr. Leroux, dean of the phyficians of Paris, pronounced a difcourfe over his body. The coffin, covered with the mantle of a dodtor, and with the different orders which had been conferred upon the deceafed, was afterw'ards placed in a hearfe, to be taken to its deftination, whither the deputation of the faculty, and a great number of other perfons, accompanied it.” As we have fpoken largely of the management of the hofpitals, we ftiall conclude with a few words upon the fubjedt of the lunatic afylums. The Salpetriere, under Dr. EfquiroPs management, af¬ fords as fair a fpecimen of the refult of benevolent confi- deration and exertion as any inftitution to be found in France, or on the continent. Here the claffilication of patients is attempted, and to a confiderable degree carried into eftedt ; though, without doubt, there is Hill much to be defired. The ufe of chains, and all that apparatus of feverity which formerly obtained, are entirely done away; and the refult has pretty clearly demonftrated that in an inftitution of this kind, properly condudted,they are ufelefs. Confinement and the ftrait-vvaiftcoat, we are told, are the only reftraints now had recourfe to at La Salpetriere. The latter of thefe, for very good reafons, is very much abandoned in this country : it is never ufed at Rethlem, and very feldom at St. Luke’s: its in¬ expediency is very apparent. The patient is quite in¬ capable of aflifting himfelf in a thoufand little neceffary offices; and, when locked up by himfelf, this becomes unufually irkfon-.e. When the wrifts are manacled to¬ gether, even the mod furious are helplefs : or a leathern girdle may be put round the waift, and the arms may be pinned down to this in a way to prevent any injury. The treatment purfued here is no longer the decided and adtive one, in the way of bleeding, purging, &c. which ufed to be pradtifed. M. Efquirol confiders men¬ tal alienation as an acute difeafe, having its fuccelfive pe¬ riods of intenfity, decline, and convalefcence, the order of which is not to be difturbed by officious interference, though the fymptoms are to be moderated by gentle means, viz. tepid baths, diluents, occafional foothing medicines, and very flight douches. Speaking to Dr. Clark of relapfes, he faid that he had known many cafes where aparoxyfm had occurred after bleeding; in fome cafes after a fmall, in others after a large, bleeding. The treatment is made as much moral as poffible. An effort is made to gain the confidence of the patient; and this is generally obtained by appearing to take an intereft in his affairs, and by fcrupuloufly preferving good faith. As much work is given them as can be procured. The convalefcents have a large room where they are em¬ ployed at their needle; and, by way of encouragement, they receive a trifling remuneration for their work. M. Pinel, as is well known, removed the regular fervants from the inftitution, and fet the convalefcents, with much profit to themfelves and their unhappy compa¬ nions, to attend upon the patients, and do the little me¬ nial offices. Dr. Efquirol, from 800 diffedtions which he has made, has come to the conclufion that “ he has never found any conftant alteration in the ftrudture of the brain, or of any other part. The hardnefs of the brain, infifted upon by many, he had not generally remarked.” The excellent regulations we have juft noticed belong to Paris, not to the provinces. But the Report of the Committee appointed by the Britifh parliament produced a fenfation on the public mind which was ftrong and per¬ manent ; and, we rejoice to fay, that its good effects have not been confined to England alone. The govern¬ ments on the continent have taken alarm, and invefti- gation has every-where commenced. The French go¬ vernment appointed Dr. Efquirol to vilit all the recepta¬ cles for lunatics in France; and the refult of a tour which he undertook for that purpofe, is ftated in a “ Memoire prefenteau Miniftre de lTnterieur.” It is but juftice to Dr. Efquirol to ftate, that this Memoir is drawn up with much ability and feeling; and, as far as we are able to judge, with ftridt juftice and candour. It, in fadt, does equal credit to the head and heart of the writer. “Thofe for whom I plead,” fays Dr. Efquirol, “ are the moft interefting members of fociety; for they are almoft always thevidtims of the prejudice, injuftice, and ingra¬ titude, of their fellow-creatures. Among them are to be found fathers of families, faithful wives, Ikilful artifans, brave warriors, and diftinguifhed literary characters, ardent, proud, and acutely fenfible minds ; and yet thefe individuals, who ought to attradl a peculiar degree of fympathy and intereft; thefe unfortunate beings, fuffer- ing under the moft fearful of human miferies, are treated worfe than criminals, and reduced to a condition below that of the inferior animals. I have feen them naked, or half covered with rags, with only ftraw to protect them from the cold, and wet pavement upon which they lay. I have feen them badly fed, without air to breathe, water to quench their thirft, without, in faff, the firft necefiaries of life. I have feen them in narrow, dirty, infedtious, cells, without air, without light, chained in dens, where we fliould hefitate to confine the wild animals which the luxury of our governments keeps up at fuch expenfe in our capitals. This is a faithful pidture of what I have feen all over France; and this is the manner in which the infane are treated in almoft every country of Europe.” The infane, in France, are almoft all placed in public eftablifinnents ; either in inftitutions fpecially devoted to them, in hofpitals, in the depdts de mendicitS, or in boufes of correction and prifons. They amount to 5153 in number, and occupy 59 houfes; out of this number, more than 2000 belong to the three great eftabliflimentsof Paris. It is rather Angular, that in the fouthern pro¬ vinces of France, the proportion of men confiderably ex¬ ceeds that of women; while, in the north, the reverfe is obferved. In Spain, the proportion of men is greater than that of women. There are only eight eftablifhments peculiarly dedi¬ cated to the reception of lunatics in France. Thefe are at Armentieres (for men only), Avignon, Bourdeaux, Charenton, Lille (for women only), Marfeilles, Marville, Rennes. There are feveral glaring defeats in thefe infti- • tutions. At Charenton, for inftance, part of the infti¬ tution is ufed as a workhoufe for the poor of the neigh¬ bourhood. Epileptic patients are mixed with the luna¬ tics, and prifoners are occafionally confined in the fame houfe. Incurable cafes are dlfo received, and are kept there for life. So it may be faid, that there is in France no inftitution fpecially devoted to the treatment of infi¬ nity. In thirty-three towns of France, which M. Efqui¬ rol fpecifies, the infane are received into the general hof¬ pitals, which are alfo appropriated to the old, the infirm, and the difeafed ; to venereal patients, and to thofe af¬ fected with cutaneous diforders, and which even admit women of diforderly lives, and criminals. In the cities where dep'ots de mendicity have been eftabliflied, a portion of the building is devoted to lunatics, but only to thofe who are furious ; thefe are kept conftantly chained in their 52 PATHOLOGY. their cells. The others, intermixed with paupers, are without any of the care which their ftate requires. Dr. Elquirol fpecifies twelve places where lunatics are received into the depots de mendicite. In feven towns, lunatics are even confined in prifons, and chained by the fide of the moft abandoned criminals. The latter can work, and the produce of their labour enables them to procure many comforts: the infane are deprived of this refource, and expofed to the jefts of the moft abandoned wretches. How humiliating muft their ftate be, if a lucid interval reveal to them their fituation; and if, in fpite of fo many obftacles, a cure ftiould be effected, how dreadful muft the recollection be of fuch fcenes ! Our author now proceeds to give, in a general way, the refult of his obfervations. The buildings devoted to the infane in France are bad: for they are always con¬ fined, damp, and generally in a ruinous ftate; and even in the depots de mendicite, and fome hofpitals where new buildings have been erefted for the infane, they have been conftrudted without reference to the objedt for which they are intended. The cells are dreadful : without air or light, narrow and damp. They are paved like the ftreets, are often under ground, and fometitnes in caves. They have feldom any other aperture than the door, and a finall fquare hole oppolite to it ; and very often, even this aperture is wanting. There is, confequently no cir¬ culation of air, and the fmell is almoft fuffocating. Al- moft all the inlane, not only the indigent, but thofe who pay, are naked, or only clothed in rags. They receive the tattered garments which have been thrown off by the poor, or the prifoners. Straw is all they have to protedt them from the humidity of the ground, and the coldnefs of the air; andftraw is fometimes wanting ! “J’ai vu un inalheureux imbecile, tout nu et fans pail le, couche fur le pave. Exprimant mon etonnement d’un pared abandon, le concierge me repondit que l’adminiftration ne lui paf- fait, pour chaque individu, qu’une botte de paille tous les quinze jours. Je fis remarquer a ce barbare que le chien qui veillait a la porte des alienes etait loge plus fainement, et qu’il avait de la paille fraiche et en abon- dance ; cette remarque me valut un fourire de pitie. Etj’etais dans une des grandes villes de France!” In no inftitution is there room enough for the patients to take air and exercife. The fpace allotted for that pur- pofe is promifcuoufly devoted to both fexes ; and, in fome houfes, the patients are brought out and “chained to the walls of the court, by way of taking the air.” The attendants are infufficient, and ignorant; and, indeed, in moft houfes the patients have no fervants. In prifons, the jailor, who has fifty or lixty criminals to look after, has alio to attend to beings who have not the power of expreffmg their wants. Chains are every-where employed: i. On account of the wretched ftate of the buildings : 2. From the infuf- ficiency of attendance : 3. From the ignorance of the keepers: 4. From the expenfe of waiftcoats. “J’ai envoye des gilets pour fervir de modele dans plufieurs villes; on ne s’en fert point par economie ; il eft certain que les chaines coutent moins d’entretien.” The chains employed confift of iron collars, girdles, and fetters. In one inftitution, the patients were confined by means of an iron collar attached to a chain, a foot and a half in length. A whip is in the hands of the fervants, and the bunch of keys is made a common inftrument of correc¬ tion. In all the eftablifhments of Paris, containing 2000 individuals, corporal punilhment has been long abolilhed. The medical men in the different towns have made many efforts to remedy thefe abufes ; but, difappointed in their attempts, they have become difgufted, and only vifit the infane who labour under illnefs, but never with a view to cure the infanity. The fervants of the hofpital order the means which they judge neceffary. At Tou- loufe, from time immemorial, it has been the cuftom for the medical men to vifit the indigent in the general hof¬ pital, but they never go into the quarter where the infane are confined. The magiftrates, deceived by falfe reports, and fright¬ ened at the tales with which interefted keepers awaken their fears, never vifit the lunatics; reconciling their confciences to this adt of negledl, by viewing the patients in the light of incurables, and thinking they have done enough when they have put them out of a ftate to do harm, and given them bread and water fufficient to keep them from ftarvation. Having detailed the abufes which exift, our author next proceeds to confider the belt method of remedying them. The outline of his plan is fomething like what has been propol’ed in England ; to build afylums in various parts of the kingdom, which fhould be appropriated to lunatics only. Dr. Efquirol is of opinion, that about twenty of thefe buildings would be required for the whole kingdom of France; and, as there are already three at Paris and eight in the provinces, he would retain thefe for the fake of economy; and, after radically reforming them, built nine others ; all which he would place un¬ der the direction of a managing committee, to confift of the prefects of different departments, fubfcribers, ma¬ nager, phyfician, &c. The diredtors and phyficians to be in conftant correfpondence with a central committee, im¬ mediately under the fuperintendance of the minifter of the interior. In conclufion, Dr. Efquirol announces his intention to publilh an extenfive work on infanity, which may perhaps afford us an opportunity of refuming this intereftingfubjedl. In Italy, the madhoufes are in a ftate equally lamen¬ table, or more fo. Dr. James Clark (Medical Notes on the Hofpitals of France, Italy, &c. 1820.) has given us fome fhocking inftances at Turin and Genoa; and the temper of the Sardinian government does not lead us to expedt any prompt amendment, as reformation is not the order'of the day in that unhappy country. Dr. Clark fays, “The part of the hofpital (Cafa de’Pazzi) we were firft taken to, confifted of fmall rooms fimilar to thofe gene¬ rally met with in fuch inftitutions ; but I was difappointed to find thefe were not for the poor patients, but for thofe who paid a certain fum for being kept. The firft of thefe that was opened prefented to us the wretched prifoner, perfectly naked, and chained down to his bed by both wrilfcs. He had raifed himfelf in his bed as far as his chains admitted, by which movement he had call off the fingle coverlet that had been thrown over him. He had no Hurt; his legs (apparently red and fwollen from cold) were drawn up under the corner of the bed-cover, which lay over a fmall part of his body ; he was pale and emaciated ; he uttered not a word. In Ihort, a human being in fo wretched a ftate I had never before feen ; but I was foon to witnefs others in a ftate ftill more horrible. We were next condudted into a ward where thirty beds were huddled together, on moft of which lay a poor wretch chained by one or more limbs to the bedftead ; for to each corner of thefe was attached a maffy iron chain, with a clafp of the fame materials and ftrength at the extremity, for admitting the wrift and ankle; and, according as the keeper judged neceffary, one or more of thefe were applied. Some were polilhed and bright as filver, from conftant ufe. I imagined that thefe were the moft unruly patients, but was told that this was by no means the cafe. To thefe we were next led ; and, on unbolting the door of a large cell, the fcene that prefented itfelf almoft exceeds belief. The fpedlacle of the poor wretches, naked, or covered only by fome ftraw, chained down hand and foot to their bedfteads ; the clanking of their chains ; the dreadful vociferation they fet up at the fight of him who had rivetted thefe chains; the ftill more horror excited by fuch a fpedlacle ; no terms are ftrong enough to depidt ! I had read and heard of chains and other means of torture for fubduing (irritat¬ ing) the unfortunate maniac; I had even feen fuch, 1 fngly PATHOLOGY. 53 fingly chained to the wall by the neck, like an infuriated and dangerous beaft ; but a den like this, crowded and crammed with human beings, chained down, without a rag of covering, ftruggling to raife their heads, and ex¬ hibiting their emaciated and galled limbs from the heap of ftraw that had been thrown over them, was a fcene I never expected to witnefs, and which I hope I may never witnefs again. In this cell there were twelve men, three of whom only were allowed any thing more than ftraw to cover them. Some I was told had been confined there for many months. On approaching them, they exhibited their chained limbs with the moft earneft entreaties for libe¬ ration. One man had two chains on one arm. In this cafe the fpace between the iron clafps was red, fwollen, and ulcerated ; and the mortification, which in all pro¬ bability was to follow, would foon render chains unne- ceffary for him. Others had their limbs galled, but not in fuch a degree as that defcribed. In one inftance only, in the whole hofpital, did I obferve any thing introduced between the iron ring and the limb. The reft of the men’s wards were fimilar to that I firft noticed. “From the men’s we were led into the women’s de¬ partment, which was in the higher part of the houfe, and which, in every refpeft, we found fimilar to that we had juft left, the beds huddled clofely together, chains always ready, many applied, and moft of the beds oc¬ cupied ; for, whether to fave trouble, or from the poor creatures having no clothes but the coverlet that was throw n over them, almoft every one wras in bed. Here, as below, was alfo a cell where ftraw afforded the only co¬ vering, where the chains were more heavily applied, and where the date of furious defperation to which the wret¬ ched viftims were driven, was exprelfed in terms equally violent, and ltill more affedfing. One of thefe tortured women held up her arm which w’as raw, and had been bleeding, from the iron clafp having worked its way into the fiefh i “ Such is the dreadful ftate of this houfe, wdiich con¬ tains 180 males and 97 females, of whom one third, the keeper told me, were kept conftantly chained. From the fame fource I learned, that the annual number of deaths (and this, I apprehend, is the principal way in which this houfe gets rid of its inhabitants) fometimes amounted to eighty (nearly one third of the whole); that it had b$en as few as thirty ; and that the average was fifty (nearly one fifth); a mortality, I believe, unequalled in any inftitution of the kind in any country.” But we now turn to a more pleafing topic, the general ftate of patho¬ logy in Italy. We have mentioned the celebrity the Italians acquired in the 17th century as profeffors of anatomy; and W'e may obferve of the prefent asra, that the labours of Volta, Scarpa, Fontana, Roffini, and Mafcagni, have much con¬ tributed to maintain that reputation. As far as the practice of medicine is particularly concerned, until of late, it appears to have been in a very lamentable condition yp to the year 1812.. The Italian phylicians were divided into Brownifts, humorifts, thofe who followed French t rpedunte fyftem, and a few who praclifed more correblly according to precepts originally derived from Sydenham. To thefe are now added others who adopt what is called the conlra-J'timvlant method, (fee p. 41.) and who boaft among their diftinguifhed advocates Tommafini andBorda. It was Rafori, however, who firft introduced this nuova dcctrinu medica Italianu. During the memorable blockade of Genoa, that phyfician obtained very great opportu¬ nities of ftudying the progrefs and charabfer of petechial difeafes ; and the calamitous refults which followed the application of the means recommended by Brown in al¬ moft all cafes foon led him to attempt a contrary plan of treatment, the l'uccefs of which amply proved that thefe fevers were of an inflammatory nature. Further invef- tigation convinced him that fcarcely any difeafes could be traced to diredl debility ; and he accordingly eftablifhed that theory of fever of which the leading features corre- Vol. XIX. No. 1286. fpond very clofely with the obfervations of the Englifh pathologifts. The medical fchool of Bologna, which is in a very flourifhing condition, may be confidered “at the head of the new doctrine;” and the profeffors, among whom we find the name of Tommafmi, its moft zealous and able advocates. A periodical journal, too, has been eftablifhed at this place, to give an account of the rife and progrefs of thefe opinions. In the mean time, thefe opinions are warmly oppofed by many of the Italian phy- ficians. Among the moft diftinguifhed of thefe oppo¬ nents areSpallanzani of Venice, (a nephew of the cele¬ brated Spallanzani,) and Federigo of Venice; but their ef¬ forts are not calculated to have much influence in the medical world. The dodtrine of this fchool in regard to the operation of drugs merits our moft earneft confideration. The grand axioms in Rafori’s theory, and that in which it is moft ftrenuoufly oppofed to the dodtrines of Browne, is that “ there exijis a clajs of fubjlances whoj'e uEtion reduces fever ; Jlackens the circulation ; and, if pvjhed too fur, induces diredl debility, without the intervention of any notuble dif- charge .” Inflead of prefuming to argue upon this An¬ gular and bold affertion, we fhall avail ourfelves of the “ State of Medicine,” appended to Lady Morgan’s Italy, by Sir Charles Morgan, M. D. for a full expofition of Rafori’s dodtrine, and alfo for fome very juft and per- fpicuous remarks on the general ftate of medicine through¬ out Italy at this time. Alluding to the axiom ftated above, Dr. Morgan pro¬ ceeds thus : “The notions formerly entertained of thefe drugs were, that they operated by diminifhing or dilut¬ ing the mafs of circulating fluids ; in which they were fuppofed to coincide with the operation of letting blood. The contru-Jlimulunt dodtrine attributes their utility to their diredt impreflion on the living folid ; to an adtion which, when exceflive, will extinguifh life by an inftan- taneous exhauftion. In this clafs of fubftances mull be placed aconite, digitalis, antimonials, and in general all mineral fubftances, cicuta, the venom of the viper, the laurel-water and pruflic acid, camboge, tea, coffee, &c. &c. The clafles of ftimulants and contra-ftimulants, according to this theory, Hand oppofed to each other in their relations to the living fibre, and ferve mutually as counter- poifons to each other. •-Hence, fay the advo¬ cates for this dodlrine, has arifen the abundant life of coffee among the Turks, as an antidote to the opium they employ fo largely. Hence alfo the utility of the vegetable acids as counter- poifons to the fame drug. The contra-ftimulant eft’edl of lemon-juice is much greater than is commonly luppofed. The author, when at Naples, having experienced a flight coup de foleii, in¬ ducing a bilious vomiting and febrile paroxyfm, adopted, under the advice of the natives, the free ufe of lemon¬ ade. Two or three quarts of this fluid, taken in the courfe of the morning, not only removed the difeafe, but induced a degree of debility fufficiently irkfome to re¬ quire vinous ftimulation. One of the moft important fails attached to this doftrine is, that the effeit of any given dofe of a contra-ftimulant drug upon the conftitution, is inverfely as the degree of ftimulation; and conlequently, that, in inflammatory difeafes, the patient not only requires quantities totally unufual in Englifh practice of thefe remedies, but bears them without any notable eft eft upon the excretions. In practice, therefore, the meafure of the dofe is found in the quantity of excitement; and no dofe is deemed exceflive which does not change the diathefis and induce dangerous debility. Thus in fthenic maladies, the Italians employ aconite, from a grain to a drachm ; the kermes mineral, from eight to twenty-eight grains ; eme¬ tic tartar, from eight to feventy-eight grains; the laurel- water, from ten to lixty drops ;.” The chair of the Surgical Clinic is filled by profeffor Vincent Kern, who gives daily leCtures upon the prac¬ tice of furgery in the operation-room adjoining to the wards. This clinic, indeed, owes its origin to profeffor Kern, and has exifted only fince 1806. The number of male patients admitted is eight, and of females fix. They S are • PATHOLOGY. 66 are ufually chofen from among the patients of the hof- pital who are admitted gratuitoufly ; but, when impor¬ tant operations are about to be undergone, it frequently happens that patients who pay prefer paifing into this clinic. This clinic is public to everyone who leaves his name with the profefl'or. The lludents of furgery of the fecond year are obliged to attend, and to undertake the care of patients, as the Undents of medicine do in the clinic for internal difeafes. From fixty to eighty lludents follow the clinical vifit, but the operations are much more numeroufly attended. The vifit is at ten o’clock every morning. With this clinic is connedled a particular inllitution, or J Jlamfclwle, as it is ftyled, for the education of fur¬ gical operators. Profefl’or- Kern has the liberty of feledl- ing fix individuals from among his pupils : thefe he in- ftrudls privately for two years, exerciling them efpecially in the various operations of furgery upon the dead fub- jedl ; after which they are permitted publicly to operate upon the living. Profefl'or Kern, indeeed, leaves almoft all- the operations upon the clinical patients, except li¬ thotomy, to be performed by his pupils, while he him- felf takes his place as their afliftant. The pupils who are feledred for this purpof'e are notin every cafe lludents of furgery, but are fometimes graduates in medicine, whofe peculiar talents and inclination lead them to the practice of furgery. They live in the hofpital, and receive from the emperor a yearly ftipend, in consideration of which they are afterwards obliged to ferve the Hate for a certain period. In general they are fpeedily promoted to be furgeons of hofpitals, regimental lurgeons, or profefiors of furgery in fome of the lyceums. Profefl'or Kern is diftinguiflied by his extreme attach¬ ment to flmplicity in his furgical inftruments, and me¬ thods of operating. His lithotome is a fliort and thick knife, of a very Ample and almofl uncouth form. The flmplicity of his external treatment of furgical difeafes is- Hill more remarkable. His fchool may well be called the School of Nature; for he trulls almofl as little to art as did Maiftre Doublet, the contemporary of Ambrofe Pare, of whom Brantome tells us ; “Et toutes fes cures faifoit le dit Doublet par du Ample linge blanc, et belle eau Ample, venant de la fontaine ou du puits.” - Pro¬ fefl'or Kern has baniflied from his practice almofl all the common applications, fuel) as ointments, plafters, lotions, lint, tow, and even bandages*; and has fubfti- tuted in their place the application of water, and a Am¬ ple covering of linen. This plan of treatment he fol¬ lows even with his private patients; and it certainly fliows no fmall firmnefs, to humour the prejudices of the public fo little, as never to prel'cribe a plafter or a fldve. In amputation, profefl'or Kern makes ufe of iced water, which hfe applies by means of a fponge to the l'urface of the flump, as foon as the large vefi'els are tied. This application, fo far from being painful, appears to give eai'e. The edges are then brought together by ad- liefive ftraps. The flump is covered with a large flat fponge, dipped in cold water, and wrung between the fingers; and this is continued for forty-eight hours. In fome cafes, this application is changed for a folded piece of linen moiftened with warm water, and applied over the adhefive ftraps. The fame mode of treatment is fol¬ lowed with all wounds after operation. The edges are brought together by adhefive ftraps, and then water is applied. No ointment, no charpie, no bandage is em¬ ployed. The fuccel's of profefl'or Kern in his operations is very great. The extreme flmplicity of profefl'or Kern’s practice is a fubjedt which never fails to excite the attention of thofe flrangers who vifit his clinic. The cafes under treat¬ ment are feen to be going on well ; and the l'uccefs is ac¬ knowledged by all to be extraordinary. Yet the ufe of water, as almofl the only external remedy , is a pradlice which by no means meets with a favourable reception. There are few, even of profefl'or Kern’s pupils, who advocate this practice'; many feem to think it unworthy of fe- rious examination, and to feel as if fuch a Amplification of furgery were a degradation of the art ; others blame the pradlice with much afperity, yet without^daring to deny the fuccefs with which they fee it attended. Thofe who addrefs the profefl'or upon the fubjedl, he refers to the patients before them ; or, if he enter into any de¬ fence of his opinions and practice, it is nearly in the fol¬ lowing manner : “ At the commencement of my furgical practice, I had a patient brought to me with a large ulcer on the leg, which had refilled all kinds of oint¬ ments and plafters. . I told the man to lie in bed, to re¬ main at reft, and to give up all applications except a poultice, fn three weeks the ulcer was ciofed. This, and many fimilar fadts, have convinced me of the bad effedts of the ufual treatment, and led me to the ufe of a more fimple plan of cure. I employ water as an indif¬ ferent matter, to cover a furface which is deprived of its natural infulator, the external Ik in, and to protect that furface from injurious influences. It adls favourably upon the circumference of the lore, as well as upon the lore itfelf. Ointments and plafters, on the other hand, are irritating and prejudicial fubftances, when brought into contadl with an uncovered furface, naturally unac- cultomed to any fuch foreign imprelflons. As wounds of bones, for inltance fradtures, are healed wfithout any external application, fo may all wounds of the foft parts be cured. The cure of wounds is the work of nature. Even gangrenous, venereal, and fcrofulous, ulcers, re¬ quire only a proper, internal treatment, and the ufe of external warmth applied by means of water. Cold, again, applied by means of a fponge to recent wounds, leflens in the moll effedlual manner the organic readtion, dimi- niflies pain, moderates luppuration, and prevents ner¬ vous affedlions. Bandages may be difpenfed with, except in a very few inftances. The journals of this clinic are open to your infpedtion.” A farther account of profef- for Kern’s opinions may be found in his “ Annalen der chirurgifchen Klinik,” 2 vols. 1809 ; and in his treatife “ Ueber die Abfetzung der Glieder. Wien, 1814. The Opthalmological Clinic. — It is neceflary accurately to diftinguilh thofe practitioners w>ho have of late years applied themfelves in Germany to the difeafes of the eye, from the clafs who are termed oculijis, whether of that or of any other country. The latter would wilh to divide furgery into a number of trades, of which they would monopolize one. The former have not confined them¬ felves to the eye, but all of them have come prepared to the ftudy of that organ by an intimate acquaintance with medical fcience in general, and many of them have dif- tinguilhed themfelves by their labours in anatomy, and their improvements in the pradtice of furgery; as for inftance, Richter, Schmidt, Barth, and Prochalka. Thefe men have not regarded eye-difeafes as local merely. They have rendered eye-operations lei’s frequent, by their rational and conllitutional treatment of thofe affedlions which give rife, under mere local and empirical manage¬ ment, to the morbid changes of the eye which afterwards call for the interference of the operator. Vienna is at prefent the moll celebrated fchool for the furgery of the eye in Germany. Profefl'or Barth, who is by birth a Maltefe, and (till lives in Vienna, as emeritus- profeil'or of anatomy, was the firft public teacher in this branch of furgery in Aullria. He is but little known by his writings on this fubjedl, not having publilhed any thing upon the difeafes of the eye, with which we are acquainted, excepting a fmall tract, in which he deferibes a manner of performing extradlion of the cataradl without an afliftant. He has many pupils, however, who Hill fpeak of his left’ons with refpecl ; and the prefent pro¬ fefl'or of pradlical opthalmology was, for a coniiderable number of years, his afliftant. By the late John Adam Schmidt, the fame of Vienna as a fchool for the difeafes of the eye, was much dnereafed. He did not belong to the general hofpital, nor to the univerllty, but to tire jofephine PATHOLOGY. Jofephine Academy. He is well known by bis opthal- mological as well as by his other writings, and efpecially by his treatifes upon the Difeafes of the Lachrymal Or¬ gans, and upon the Inflammation of the Iris. He wrote a confiderable part of the opthalmological Bibliothek of Himly ; and it were to be wilhed that fome of his coun¬ trymen would treat his memory with more refpeCt, and acknowledge what they have borrowed from his valuable communications to that journal. Dr. George Jofeph Beer has been for more than thirty years employed in the practice of this department of I'urgery. He was for many years extraordinary profeffor only ; but in the year 1815 a chair of practical ophthal¬ mology’' was founded in the univerfity, which has flnce been filled by this learned and enthufiaftic man. The name of profeifor Beer is already known in England. He is a voluminous author, but all his works are upon the fiubjeCt of his favourite lludy. The Clinic for the Difeafes of the Eye has undergone various improvements within the laft ten years. It has exifted in its prefent lituation in the General Hofpital, and with its prefent arrangements, fince November 1816. The clinic confifts of an auditorium, and of two wards, on the fecond floor of the hofpital. The auditorium is well lighted, and neatly covered in green. The windows are fofupplied with flutters and curtains, that the light can be in an inftant increafed or diminiflied. A large ealtern window fupplies the light admitted during ope¬ rations. Befides feats for one hundred and fifty ftudents, this room contains a cathedra of an oval form, raifed about a foot and a half from the floor, and furrounded by an iron baluftrade. From this the leflures are de¬ livered, and it is ufed alfo for the operations, being large enough to contain a patient, along with the profeffor, the alfiftant, and the ordinarius, or pupil to vrhofe care the patient is intruded. A collection of inftruments and bandages both for the ufe of the clinic, and for the il- luffration of the hiftory of ophthalmology ; a collection of anatomical and pathological preparations of the eye ; and a library of printed books, manufcripts, and drawings, illuftrative of the ftruCture and difeafes of that organ ; are contained in the auditorium. The duff of negleft is not allowed to gather on any of thefe collections. They are, on the contrary, yearly increafing. The library is open to the ftudents. The auditorium is adorned with a buft of the prefent emperor; and portraits of Baron Protomedicus Von Stilt, the director of medical ftudy in the Auftrian dominions ; and of the following diftin- guiflied furgeons ; Scarpa, Richter, Schmidt, Barth, and Prochalka. Each ward is about the fame fize as the auditorium, is alfo coloured green, and contains twelve beds. The wards are feparated from the auditorium by two fmall rooms appropriated to the ufe of the nurfes. In the middle of each ward is a long table, which ferves Jioth as a dining-table for the patients, and alfo for laying out the bandages, inftruments, and medicines, made tffe of at the vifit. The windows are fupplied with fhutters and curtains. Each bed has three fuch fubftitutes lor curtains as we have already defcribed at p. 64. The wards are furniftied with every thing neceflary both for the ftriCtnefs of clinical inftruCtion, and for the peculiar care of patients affeCted with dileales of the eye. A fa- laried alfiftant, refiding in the hofpital, is alfo attached to this clinic. The inftruCtions delivered in this inftitution, which, as in the other clinics, are continued uninterruptedly for ten months, are given in the following order. The lec¬ tures on Practical Ophthalmology are delivered every morning, Saturdays and Sundays excepted, from ten to eleven o’clock, in the German language. The ledtures commence with a very complete account of the anatomy and phyliology of the eye, in which conllant reference is made to the morbid changes to which the various tex¬ tures of that organ are liable. The difleCtions of the eye and of the neighbouring parts, which are made for this 67 part of thecourfe, are very numerous, and are executed with great care, chiefly by profeffor Beer himfelf. Stu¬ dents can readily procure admiflion when thefe diffec- tions are preparing; and thus have an opportunity of becoming more intimately acquainted with the practical anatomy of the eye, and with lome peculiarities in Pro- feffor Beer’s mannerof demonftrating that organ. Under the anatomy of the eye, Profeffor Beer includes the of- teology of the orbit, and the demonftration of the muf- cles, blood-veffels, nerves, and all other parts connected with the organ of vilion. H§ borrows frequent illuftra- tions from the comparative anatomy of the eye; and pof- feffes a finer collection of original drawings in this par¬ ticular department than is perhaps in the hand of any other anatomift. To this part of the courfe, which lafts .about two months, follows a few leftures upon the man¬ ner in which the difeafed eye ought to be examined. The next and principal part of the courfe continues for nearly fix months, and is occupied with the pathology of the eye, and the medical and furgical treatment of its difeafes. The whole concludes with a hiftory of opthal- mology from the mod ancient times to the prefent, and a critical review of the moft celebrated works in this fcience. Daily, from eleven to twelve, Saturdays and Sundays included, the ftriClly-praCtical inftruftions are given, partly at the bed-fides of the patients who have been ad¬ mitted into the clinic, and partly in the review of the ambulatory or out-patients. The plan followed by pro¬ feffor Beer is to bring every new and interefting patient, whether he be afterwards to remain in the clinic, or to be an out-patient only, into the auditorium, and to place him in the cathedra. Any one of the ftudents may now offer himfelf to be the ordinarius, or candidatus uj]ijlens , for this patient ; and, entering the cathedra, may exa¬ mine the fymptoms, pronounce a diagnofis and prognofis, and propofe a plan of treatment. Ail this is done under the correftion of profeffor Beer, whofe earned defire to communicate inftruCtion in thefe practical exercifes merits the moft unequivocal applaufe. It is here perhaps that profeffor Beer moft diftinguifties himfelf. We do not mean to leffen his fame as an eye-operator, already fo widely and fo well eftablifhed ; but we muff confefs thafi it was ever as a diagnoftician that he appeared to us to rife beyond all' rivalfhip. The number of ftudents who attended this clinic from 1814 to 1817 was as follows : 1814- 15, in. Of thefe 65 were not Auftrians. 1815- 16, 170. ... 92 . 1816- 17, 199- ... 104. . The number of patients and of operations was as fol¬ lows : In-Patients. Out-Patients. Operations. For Cataract. 1814-15, 96 1 14 92 60 1815-16, 106 158 78 57 1816-17, 115 1 80 96 59 We have already taken notice (p. 58,62) of the method of inftruClion by what are called privatijfima. Thole of profeffor Beer are extremely valuable. He gives a fiiort courfe of the operative furgery of the eye, repeats the different operations, and explains, as hegoes along, every ftep and minutiae in their performance ; and then direCfs the pupil in the repetition of each of them upon the dead fubjeCt. After attending one of thefe private courfes, the pupil is allowed to operate upon the living fubject. Upwards of thirty heads are employed in a courfe. Daily, at three o’clock in the afternoon, profeffor Beer gives advice to the poor in his own houfe; and to this houfe- clinic, as it is called, ftudents are admitted. Many of the lefs fevere difeafes of the eye may here be obferved, which are not fo frequently feen at the hofpital ; and the Undent finds in profeffor Beer a friend ever ready to ex¬ plain, and to aflift him in the examination of the cafes. The fee for the clinic is twenty-five paper guldens yearly. 68 P A T H O yearly, ( 19s.) for the houfe-clinic a ducat, (10s. 6d.) for a prixali jfimum eighty paper guldens, and for each operation upon the living fubjedt four ducats. For Dr. Rofa’s privatijfinmm, twenty-five paper guldens. For each head for operations, one paper gulden. The Gebaerhaus, or Lying-in Hofpital, was eftablifhed by the emperor Jofeph II. in the year 1784, partly with the view of preventing child-murder. In the courfe of the firlt year after it was opened, 748 children were born in this hofpital. It forms part of the General Hofpital, and is under the fame management; but is feparated in fonie meafure from the other buddings of the hofpital by a fmall court. This eftablifhment is divided into two fedtions. The one is for thofe women who pay; to the other admiflion is gratuitous. The former is committed to the fuper- intendance of Dr. Pelan, and is not open to ftudents ; the latter conftitutes the Clinical School of Midwifery, and is under the care of profeffor Boer. The Private Lying-in Hofpital confifts of two di'vifions. The one contains twelve rooms on the ground floor, which are fet apart for fecret deliveries, and the greater number of which are occupied each by a Angle patient. The other divifion contains fix rooms, each of from four to fix beds. In the firlt divifion, if the room is not oc¬ cupied for a complete day, fix paper guldens are paid. If the perfon continues longer, flie pays daily a gulden and a half ; for which flie has board, lodging, medical attendance, nurfing, and the baptifm of her child. If {he gives over her child to the foundling-houfe, fire pays forty guldens. Befides the accoucheur, midwife, and nurfe, no perfon is allowed to enter her room. In the fecond divifion, there are indeed feveral beds in each apartment, yet there is fuch an arrangement, that thofe who have been are feparated from thofe who are to be de¬ livered. A perfon who does not remain in this divifion during an entire day, pays four guldens and a half. If fire remains longer, (lie pays daily half a gulden. Alfo here, none but the neceflary attendants are admitted. If a woman of this divifion would give her child into the foundling-houfe, flie pays twenty guldens. This {'edition of the lying-in hofpital was intended by the imperial patriot as an afylum for thofe who might with to conceal their pregnancy; and here thofe indivi¬ duals find that they are fafe from difcovery. Even the tribunals are obliged, if it be brought as a corroborative ground of accufation againft a woman that (lie had refided in the lying-in hofpital, to rejedl the evidence to that eftett as not valid. On entering the hofpital, the woman is not required to tell her real name or condition, much lefs to declare who is the father of her child. She is re¬ quired merely to bring along with her a fealed letter containing her real name, that in cafe of her death infor¬ mation may be communicated to her relations. Asfoon a$ the number of her room and bed is written upon the letter, it is returned into her own keeping. She can enter the hofpital and leave it in difguife, or even nialked ; and indeed continue fo during her whole reli- xience, if flie choofe it. If (he bring a nurfe along with her, flie need not expofe herfelf even to the nurfes of the hofpital. She can leave the hofpital immediately after her child is born, or remain for fome time. She can leave her child, or remove it. Many make ufe of this inftitution only during labour, leave it fome hours after their delivery, and give up their child to the foundling- houfe. The rooms of this fedtion are neither fo fpacious nor fo clean as thofe belonging to the fedtion for the poor, but are more crowded. Notwithllanding, they contain fewer lick in proportion to the number they accommodate, and fewer die in thisfediion. This mult be attributed in fome meafure to the greater degree of warmth, and to the avoidance of draughts of air in fmall rooms ; in which particulars tliefe are much preferable to fpacious and airy wards, efpecially for lying-in women. The average number of births in this fedtion of the lying-in LOGY. hofpital, has been for fome years pall from 800 to ioocr annually, being about a third fewer than in the clinical fchool. We fufpedt that in a confiderable proportion of thefe births, the children are illegitimate. In the tw'enty-four hours, there are on an average from two to three births. Three midwives afiift at the labours, and the accoucheur is called in only in difficult .cafes. The Obftetrical Clinic.- — The chair of clinical midwifery is filled by profefior Lucas John Boer. The fedtion of the lying-in hofpital, containing all thofe women who are admitted gratuitoufly, along with almoft all thofe who enter on the loweft rate of twopence halfpenny daily, is committed to his care. Every woman admitted gratuitoufly muft afiift in the houfehold work of the hof¬ pital, and afterwards ferve for a certain time as nurfe in the foundling-hofpital. The number of births in this fedtion is 1200 annually. The proportion of unmarried women delivered, is to that of the whole number deli¬ vered, as 47 to 50. This fedlion of the lying-in hofpital is frequently ftyled the Sc/tola Objletricia ; and it is here alone that ftudents are admitted to the practical ftudy of midwifery. Indeed it is chiefly in this fchool that midwifery is at all ftudied, at leaft by foreigners, at Vienna; for profefior Boer’s ledtures in the univerfity are for mid wives rather than male ftudents ; and the ledtures of profefior Schmitt in the Jofephine Academy interfere with the clinical vifit of profeflor Boer. Profelfor Boer vifits his clinic morning and evening. The morning vifit is from nine to ten ; and is fo far public, that foreign ftudents, who apply to profeiTor Boer, are permitted to attend gratis, and to be prefent at the deliveries which happen between thefe hours. Thofe who follow this vifit meet in the delivery- ward, and then attend the profeflor through the wards con¬ taining the women who have been delivered. Two wards for this clafs of patients are conftantly in ufe, each of fourteen beds. A third was formerly kept for the pur- pofe of emptying either of the others at pleafure ; but fometimes all the three are occupied. Into one of thefe wards, thofe who are about to be delivered are brought as foon as their labour-pains com¬ mence, and there they remain until the os uteri has di¬ lated. They then pals into the delivery-ward, which is fituated between the two large wards for women who have been delivered. The floors of all thefe apartments are covered along the fides of the beds with broad pieces of dark-coloured cloth, which are continued alfo between the wards. This prevents thofe who have been deli¬ vered from ftepping out of bed upon a cold floor, and hides any blood which may fall from the woman in la¬ bour, as (he pafles into the delivery- ward. The delivery- ward contains four beds, which are furrounded by the kind of moveable curtains formerly defcribed. No de¬ livery-chair is employed by profeflor Boer; but the bed is arranged to anfwer the purpofe of a delivery-chair, by means of ten- bags of ftraw, each three feet long, and from a foot to a foot and a half thick. Thefe are laid above the ftraw-mattrefs of the bed, and ferve to raife the head and back of the patient. Over all are laid a woollen coverlet and a (h.eet, and a coverlet of the fame kind is laid over the woman. Theaffiftant and the midwife live in the hofpital, and are prefent at all deliveries. The profefior does not live in the hofpital, and is called only in difficult cafes. There are ten male ftudents, and as many female pupils, to whofe care the patients are particularly intruded be¬ fore and after delivery, as well as during the time of labour. Six of thefe ftudents are ftyled intra-pracikanls, and the remaining four extra-pratihants. All the ten fe¬ male pupils are intra-pralikants, and refide in the Ge¬ baerhaus itfelf. The fix ftudents who are intra-pratikants refide in other parts of the hofpital. The four extra- pratikants are not Auftrians. The appointment of pra- tikunt is given by the profeflor, and no money is taken for it openly. The prelikants are the only perfon* called 4 upon PATHOLOGY. upon to be prefent at operations. A male and female intra-pratikant daily take the office of journalifts, whole duty it is to examine all women applying for admiffion, to be prefent at all deliveries which take place within the courfe of the twenty-four hours, and to enter into a book the names of the patients who are admitted into the clinic, and of thofe who are delivered during that day, but without any hidoryof the cafes. The appoint¬ ment of pratilcants continues for two months. Children’s beds are fcarcely ever employed in the cli¬ nic : the children are laid by their mothers’ fide. Swad¬ dling, a barbarity almoft unknown in England, but which holds its ground in many parts of the continent of Europe, is not permitted. After a few hours the bread: is given, the mother continuing in the reclining pofture. Many of the mothers; indeed, refufe to give the bread: to their children, knowing that in not many hours they are to be fent to the foundling-houfe. Small as the rate of two-pence halfpenny a-day is, it is furprifing how early after delivery the patients leave the hofpital, in order to fave this expenfe. We have been allured that frequently on the fecond day, and fometimes even on the next day after delivery, they give up their child to the foundling-houfe, and return home.. The greater number leave the hofpital at the end of a week. Very few remain two weeks. For feveral years ' pad:, profedbr Boer has given no clinical ledhires. Neither is there any regular lyftem of indrubtion in the practice of midwifery followed in the clinical fchool, nor is there any demon ftration of the obftetrical inftruments, nor arty exercifing upon the phantom or machine, tinder the immediate direction of profed'or Boer. The principal part of the inftruclion to be gained at this clinic, mud: be gathered from his oc- cadonal remarks and converfational examinations. His affidant, indeed, gives privalijjima , both to male and fe¬ male pupils, at ten or dfteen paper-guldens. Profedor Boer is a pupil and a partifan of the Englidi fchool of midwifery. His forceps are nearly thofe of Dr. Hamilton; but he almoll feoffs at indruments, and, like Dr. William Hunter, fums up his advice for difdcult cafes, in the word Patience. He fays plainly, that midwifery is better underftood i g England than in any other country. Little, therefore, is to be learned in the clinic of profed'or Boer of the artificial part of midwifery ; while the bed opportunity is afforded of eftimating the value of the ars objietriciu per expert a tionem. To a treatife which profedbr Boer hasqmbliffied, he has given the title of “ Elementa Medicirtae Obftetriciae Naturalis.” This work is diftinguifhed for the claffic fade with which it is written. The medical treatment of the women who have been delivered in the clinic, is in general fo extremely dmple, that profedbr Boer is wont to fay, that they cure every thing there with beer-foup, and require neither great learning nor dear drugs. The number of puerperal dif- eafes which do occur is very fmall. This is probably owing in a confiderable meafure to a regulation, which is drirtly followed, that no woman diould be left twenty- fours after delivery, without having a clyder given her, if her bowels have not been opened. In puerperal fever, profedbr Boer is a friend neither to blood-letting nor to drong faline purgatives ; but truds, as in many other cafes, more to nature than to art, ordering little more than dome powders of ipecacuanha in the commence¬ ment, clyders, fome fpoonfuls of tindture of rhubarb, a little of Dover’s powder, and emollient cataplafms to tjie abdomen. In the pain of the inferior extremities atter delivery, with or without cedema, profedor Boer has derived great advantage from a blider applied like a garter under the knee. He maintains that abfeedes of the mamma are never to be opened with the knife, but are to be treated with poultices till they open of them- felves, after which neither lint nor ointment is to be ap¬ plied. The caufe of fuch abfeedes, he confiders to be Vol. XIX. No. 1287, * GO the want of timely putting the child to the bread, and of regular fucking. To fore nipples he applies cloths dipped in warm water, and orders the child to be con¬ tinued at the bread, its faliva being the bed remedy. As foon as profedbr Boer fees aphthae in a child, he concludes that it has had tea, fugar, or fyrup, or that it has ufed a fucking-cloth. Any fuch foreign irritation, adding upon the tender mouth of the child, caufes aphthae. In the clinic, as the children get nothing but their mo¬ thers’ milk, aphthae are exceedingly rare, whereas that difeafe is extremely common in the foundling-houfe. In the ophthalmia of new-born children, profeffor Boer re- jefls all collyria, as irritating and likely to increafe the inflammation. He rejefts alfo the wadiing of the eyes with milk, as it is apt to be four. He places by the bed of the mother two cups of cold fpring- wafer. In the one fhe dips a bit of linen, and in the other waffies out the bit which die has removed. ’Thefe are frequently applied over the eye-lids. Under this treatment the indamma- tion diminifhes, the eye-lids are prevented from adhering together, and the purulent difeharge is faid to be averted. The Foundling-houfe is alfo under the fame diree- tion as the General Hofpital ; but dands on the oppofite fide of the dreet, and has its own phydeian, furgeon, and overfeer. Of late years it has been much improved by .the care of government, and the exertions of a fociety of the ladies of the Audrian nobility. This is called the “ Society of Noble Women for the Promotion of the. Good and Ufeful.” In 1814, the following were among the applications of their funds : Guldens; Care of Foundlings, and Premiums to Nurfes 9871 Inditution for the Indruidion of the Der.fand Dumb 249a Inditution for the Indru6Iion of the Blind . . 3349 Care of Patients with Difeafes of the Eye . . , 380S Support of poor Lying-in Women . 1250 All attempts to rear the children in the hofpital itfelf had failed. In the mod favourable years, only 30 chil¬ dren out of the 100 lived to the age of twelve months ; in common years, 20 out of the 100 reached that age; and in bad years not even 10. I11 1810, 2583 out of 2789 died; in 1811, 2519 out of 2847 died. Like the cavern of Taygetus, this hofpital feemed to open its jaws for t'he dedrubtiori of the deferted and illegitimate progeny of Vienna. The emperor Jofeph II. frequently vidted this hofpital in perfon ; and upon oneoccaiion he ordered profedbr Boer to make a feries of experiments with all kinds of food, that it might be afeertained how far diet had its (hare in the mortality. Twenty children w'ere feledled, and fed with various kinds of paps and foups ; but in a few months mod of them were dead. In 1813, the government enabled that the foundling-houfe diould ferve merely as a depot for the children, till they could be delivered to the care of nurfes in different parts of the country. Already, this plan has in part anfwered the benevolent intentions of thofe who fupported it, and given credit to the opinion of the medical faculty, who, in their report upon this fubjeft, attributed the mortality in the foundling-houfe, not to the want of care, food, or cleanlinefs, but to the crowding together of fo many children, and the unavoidable deterioration of the at- mofphere which hence refulted ; to the noife, and to the contagious difeafes to which the children were expofed, and efpecially contagious diarrhoea. This hofpital dill continues to contain upwards of feventy nurfes, and more than twice that number of children. Every nurfe has her own bed, and befnle it two children’s beds. In general, each nurfe has her own child committed to her care, and another child. The Inditution for Sick Children. — This inftitution owes its origin to Dr. Madalier, a celebrated and bene¬ volent phydeian of Vienna. It is at prefent under the care of Dr. Goelis, at whofe-houfe in the Wollzeil-ftreet the vifit is daily held from three to five o’clock in the T afternoon. 70 PATHOLOGY afternoon. Students who previoufly intimate their withes to Dr. Goelis, are permitted to attend, and have thus an opportunity of feeing the difeafes of chil¬ dren treated with much tkill and attention. The average number of patients is 500 monthly. Dr. Goelis has undertaken the publication of a feries of monographies upon the different difeafes of children, to which difeafes his practice is nearly confined. The vaft opportunities of obfervation, the care in conducing this inifitution, and the numerous difl'eftions of thofe children who die, lead us to hope much valuable infor¬ mation from thefe works, the firlt volume of which is already publiflied. The Jofephine Academy, confidered as a building, is one of the molt fplendid edifices in Vienna. The empe¬ ror Jofeph II. was the founder of this inifitution, the objeft of which is to fupply the Aullrian army with able phyficians and furgeons. On the front of the academy is the following infcription : “Munificentia et Aufpiciis Imp. Ca:f. Jofephi II. P. F. Scliola Medico-chirurgica, militum morbis et vulneribus curandis fanandifque infti- tuta, sede et omni fupelleftile falutaris artis inftrufta, Anno R. S. 1785.” It was opened with much ceremony upon the 7th of November, 1785; and a gold medal of the weight of forty ducats was (truck upon the occafion. The firlt direftor of the academy was Brambilla, the au¬ thor of the Inlfrumentarium Chirurgicum, and other works. To him were intruded the making of the lla- tutes, and the arrangement of the w’hole inifitution. The Jofephine Academy is completely feparated from all other fchools. It is under the direftion of the mi- nilter of war, out of whole treafury the Hilaries of the profefl'ors and all other expenfes are defrayed. The number of pupils is 200, of whom fifty receive a monthly allowance from the academy. Having finilhed their at¬ tendance of two years, to which period of time the courfe of Ifudy extends, they unde’rgo a fevere examina¬ tion, are promoted to the degree of doftor in furgery, and appointed to a regiment ; but the academy pofl'efles no power to grant the degree of doctor in medicine. There are five profefl'ors and a profeftor in the acade¬ my. The profelTors belong to the army, being ltaff-phy- ficians ; and they bear the title of imperial counfellors. The greater number of them refide in the academy. Their leftures are delivered in German. The Field- phyfician-in-chief and Director is Beinel von Bienenburg. The pupils of the Jofephine Academy have abundant opportunities for the practical Ifudy of their profellion, there being three clinics attached to the inifitution. The patients are foldiers anil foldiers’ wives, chofen from the Great Military Hofpital, which is iituated clofe to the academy, and is fitted up for 1200 patients. The Me¬ dical Clinic is under the care of profelTor Calfellitz. The vifit is from fix to feven in the morning. The Sur¬ gical Clinic is in the hands of profelTor Zang, a furgeon cf very diltinguifhed merit. The vifit is from four to five in the evening. ProfelTor Schmitt has an Oblfetrical Clinic, in which from 70 to 80 foldiers’ wives are de¬ livered in the courfe of a year. To all the leftures and clinics (trangers are admitted, who previoully leave their names with the feveral pro¬ felTors, except to the oblfetrical clinic, which is par¬ ticularly deligned for the pupils of the academy. The clinic of profelTor Zang is much frequented by (trangers. Indeed that gentleman is looked upon as one of the firlt furgeons in Aultria : he is at prefent engaged in a work, two or three volumes of which have been publiflied, upon operative furgery, which promifes to become cialfical in medical literature. The library' of the academy is rich in books of me¬ dicine, furgery, anatomy, botany, and natural hiltory, and is adorned with a buff of Jofeph II. by Ceracchi. It is open only to the profefl'ors and pupils of the academy. The collection of natural hiltory contains fpecimens from the three kingdoms of nature; but chiefly of fuch ob¬ jects as are interelfing from their ufe in materia medica and practical chemiltry. The collections of all kinds of furgical inltruments, bandages, and machines, is ex¬ tremely magnificent. The anatomical mufeum is diltinguilhed for its col¬ lections of fkeletons and difeafed bones, and of patholo¬ gical preparations in wax ; but above all for its rich col¬ lection of wax preparations illultrative of deferiptive anatomy and midwifery. The preparations of this col¬ lection were executed in Florence, under the direction of Fontana and Mafcagni, and are indeed an exact copy of the collection of the fame kind in the Mufeo di Fifico at Florence. This collection occupies feven apartments. Two apartments upon the fecond floor contain the pre¬ parations illultrative of midwifery. This mufeum is open ' every Thurfday, and is vilited by alidades of the people. The Florentine collection is much admired by the crowd, whom it is well calculated to furprife. Every preparation lies under glafs, upon a white filk culhion fringed with gold. The artills have not fpared ornament even to the preparations themfelves, which are as gay as colours can make them. It is well known that they were executed from drawings ; but it may Itartle our readers a little to hear,, that a feries of engravings, taken from thefe pre¬ parations, is now publilhing at a great expenfe in Vienna. Privatilflmaare alfo given by theprofeftorof the academy, in which thefe preparations are demonitrated. We never could look at the collections of wax preparations in the Mufeo di Fifico at Florence, and in the Jolephine Acade¬ my of Vienna, without acknowledging them to be ex¬ cellently fuited for teaching anatomy to grand dukes and emperors, or for affording an hour’s amufement to any honeft citizen whatever, curious perhaps in fuch matters. That they are of any confiderable utility to profeflional ftudents of anatomy, is by no means fo evident. The Jofephine Academy is furnilhed with a botanical garden. It has a perpetual direCfor.and fecretary; per¬ petual members or profefl'ors; aftual members, or phy¬ ficians and furgeons; foreign honorary members ; and correl’ponding members. A work of very confiderable value on Hofpital Gan¬ grene has been recently publiflied by Dr. Werneck, phyfician in chief to a divifion of the Auftrian army, who has had very extenfive opportunities of obferving the difeafe during the late campaign in Italy, Hungary, Poland, and the greater part of Germany. It is only fuch points as are either of an original charafter, or fuch as ferve to fupport doubtful points of theory, that re¬ quire notice on this occafion.- Dr. Werneck confiders that the difeafe may appear either as affeCling primarily the fyftem, or developing itfelf originally in an open wound, without any fpecific aft'eCfion of the general fyf¬ tem. He thinks that it arifes from a contagious virus, which is a modification of that producing the common typhous fever: in fupport of which notion he cites nu¬ merous fafts, furnilhing direft and very forcible argu¬ ments in its favour. Hofpital gangrene, like typhous fever, he alfo remarks, may occur feveral times in the fame individual, and affeft perfons living in an infulated manner, as well as in hoi'pitals, tranfport-lhips, or gar- rifons, where numerous individuals are collected toge¬ ther; and it maybe cured, under either of thefe clr- cumffances, with the ufe of no other meafures than fuch as are proper to maintain cleanlinefs of the wound af- fefted. Dr. Werneck has fome hypothetical opinions about the nature of the contagious virus, that it would not, perhaps, be right to negieft to notice; though it fliould be utiderffood that they are not cited here becaufe their truth is acknowledged. He fuppofes that the ef- fence of the virus is of an alkaline nature, and is to be correfted by acids, the moll efficacious of which, for the implied purpofe, is the acetic acid; next to this, the muriatic and oxy-muriatic acids; and, lalt in the lift , the other ftrong vegetable acids. Similar in its general charafter to the foregoing trea- tife, 71 P A T II O L O G Y. fife, that of comprifing a good hiftory of its fubjeCt, with obfervations and arguments qualified to fupport thofe of former well-informed writers, rather than demonftrative of any thing of remarkable originality, is the work of Dr. Rufton the Egyptian Ophthalmy. His moft important and interefting observations relate to the appearance of ophthalmy in thegarrifon at Mainz in 1818. The difeafe had been prefent in the army during the campaigns of 1813, 1814, and 1815; but it was not till the time above mentioned that it manifefted itfelf in an alarming man¬ ner. Its prevalence occurred under the following cir- cumffances. It affeCled only the men of one regiment, and, for the moft part, only fome Pomeranian, Lower- Rhenifh, and Naffau, recruits. This regiment made a very harraffing march from the Rhine to Silefia, and back again, in the autumn of 1817 and the Spring of 1818. On its return, the men were crowded into a tranfport with Several French invalids, amongft whom were many' who had loft their fight from ophthalmy. On the arrival of the regiment at Mainz, about a third part of the re¬ giment were found to have the itch. After this was got rid of, Several other cutaneous difeafes appeared, as Scar¬ let fever, meafles, varioloid difeafes, and nettle- rafh ; and, on the decline of thefe, the affeCtion of the eyes firft appeared. It augmented in Severity from June to September 1818, when it continued nearly ftationary, in regard to prevalence and Severity, till March and April 1819, wdien its extent became more confined ; but its deftruCtive agency was far from being fuppreffed until after the moft Uriel meafures for preventing its infection had been reformed to. Whilft the Pruftian regiment at Mainz was Suffering from this difeafe, the Auftrian Soldiers were entirely ex¬ empt from it, though they both lived under the fame climate and performed Similar duty. But, whilft this argument in favour of the propagation of the difeafe by contagion is brought forward, we muft not negleCt to notice thofe which favour the opinion of its primary origin from cafual external circumitances. The whole of the faCts related by Dr. Ruft fupport the opinion of Dr. Vetch, that purulent ophthalmia originating from any common caufes may become contagious; or, in other words, that a puriform Secretion from the mucous mem¬ brane of the eye, from whatfoever caufe, is capable of inferring, by contaCt, the mucous membrane of the eye of another perfon, and of thus producing a difeafe Similar to that from which it originated. It Should beconfidered that the difeafe firft appeared in the recruits in the Pruf- lian army ; that the military discipline of the Pruftian army is much more Severe and harrafting than that of the Auftrian army ; and that this Severity was further in¬ creased as the number of the Sick augmented. One part of the military discipline to which thofe recruits were Submitted, was that of having the hair cut very clofe over the whole of the upper part of the head, on their entry into the ranks, whilft they adopted the practice of conftar.tly wetting the back part of the head with beer and Soap, for the purpofe of' making their hair grow cn queue-, and a very defective covering for the head was commonly worn. Thefe circumftances may be consi¬ dered quite Sufficient to produce a difpofition to ophthal¬ mia, juft in the way in which it was manifefted. Dr. Ruft arrived at the garrifon on the 5th of April, 1819. He immediately put in force the moft effectual means for preventing the progrefs of the difeafe, fuppofing it to be communicated from one individual to another by contagion. The numberof patients now decreafed from month to month, till October, wdien the garrifon was relieved, and the difeale was fuppofed-to be w holly de- ftroyed. From June 1818, to the end of April 1819, the numberof patients amounted to 1146; from this time to September 1819, only 65a new cafes occurred ; fo that the whole numberof patients was 1798, not including one regimental phyfician, two hofpital Surgeons, and twelve nurfes, who were affeCted with the difeafe. The method of applying Sulphur in a gazeous form to the Surface of the body, w’as firft introduced by Dr. Gales of Paris. The refult of the experiments and obfervations made on its employment, by a medical jury appointed for the purpofe, was fo Satisfactory, that by order of go¬ vernment it was fpeedily introduced into all thehofpitals of France, and was generally recommended in practice by the phyficians of that country. It confifts in applying the vapour ariiing from ignited fulphur to the naked body of the patient, feated for that purpofe in a fort of wooden cafe, in the upper part of wdiich thereisanaperture for the head. To the circumference of this aperture a leather bag is attached, which isfaftened round the neck, and thus prevents the fumes of the fulphur from reaching the eyes, nofe, or mouth. The effeCt of the fumigation is to produce, in the firft inftance, increafed adlion, and fubfequently moft profufe perfpiration; greater, indeed, than we have ever- Seen produced by any other means. Hence, it appears to be indicated, ift, where quick and Ridden perfpiration is of benefit ; and zdly, where fulphur appears to have a Specific adlion. The Sulphureous fumigating baths were introduced into Germany by Dr. De Carro, of Vienna, whole name is already ennobled in the annals of humanity by the in- trodudlion of vaccination to the continent of Afia. The apparatus confifts of a wooden cafe, Something like a pulpit, in which a grown perfon can fit with eafe up to the neck. This cafe is plaftered internally. Its floor, formed by a ftone of two or three inches in thicknefs, is raifed fo far above the ground as to require three Heps to get into the cafe. Underneath are the parts neceflary for producing the fumigation. The loweft ftory is the afh- pit, the uppertnoft the hearth for the fulphur, and the middle contains the fire. The uppermoft divifion com- municates'freely with the interior of the cafe, by means of holes bored in the ftone floor of the cafe. A pipe con¬ veys the fmoke from the divifion containing the fire into the chimney. Another pipe pafies from the cafe into the chimney. This may be opened or Unit by means of a valve ; and, after the operation is concluded, it con¬ veys what remains of the Sulphureous fumes into the chimney. From this Iketch of the apparatus, the me¬ thod of ufing it is evident. The patient, perfedlly na¬ ked, Heps into the cafe, and feats himfelf on a chair, which may be railed or lowered at pleafure. He places his feet upon a ftool. Both the chair and (too! are perforated with holes, to admit the free paftage of the fumes to all parts of the body. The uppermoft board, forming the head of the apparatus, is now let down, fo that the patient is completely enclofed in the cafe, with the exception of the head. Provilion is made for pre¬ venting the fumes aCting on the eyes, or entering the mouth or nofe, as already mentioned. There are various methods of applying the vapour to the face, when the difeafe has its feat there, the moft Simple of which is a. flexible pipe, which communicates with the fulphureous vapour. The patient remains in the bath half an hour, or at moft an hour. About five minutes before the conclufion of the fumigation, the valve in the fulphur-pipe is opened, and thus all unplea- fant fmell is avoided on opening the door of the cafe. The patient now goes to bed for an hour or two. The cafes in which the fulphureous fumigation is chiefly ufed, are cafes of chronic rheumatifm, pfora, le¬ pra, and other cutaneous affections, where fulphur is ufually found of advantage. In all of thefe the benefit derived is very ftriking, and the fhortnefs of the period neceflary for the cure really aftonifning. Some cafes of old chronic rheumatifm have yielded completely in a few weeks to this remedy. One reafon of the great fuccefs attending Dr. De Carro’s pradice, was the judicious Se¬ lection of cafes which he made, whereas many practition¬ ers have employed thefe fumigations far too indiscrimi¬ nately, and then u'ondered at the failures which took place. The practice of fulphureous fumigation has been made PATHOLOGY. 72 made known to the north of Germany in a work by Dr. Karlten of Hanover, under the title of “Ueber die Kraetze, und deren bequemfte, fchnell-wirkendefte und ficherfte Heilarr, durch Baden in fchwefelhaltigen Da- empfen, und deffen vortheilhafte Anwendung zur Behandlung chronifcher Krankeiten der Haut und anderer Gebilde, nebft Befchreibung eines hierzu dien- lichen Apparats, von Dr. Karlten, mit 2 Kupfern. Ha¬ nover, 1818.” The practice is now generally adopted in moft parts of the continent, and has extended to Rufiia and Poland. Dr. Afialini, of the Inftitute of Sciences at Naples, has publilhed “ Medical Refearches on Fumigations of Sul¬ phur, Mercury, &c. Naples, 1820;” one objedt of which is, todefcribe the improvements and additions which he has made in the ccnftrudtion of the (loves employed for thefe purpofes. Of thefe, the principal feems to be, the having rendered the machines more portable, and their ufe more economical, than thofe propofed by G.ales, Darcet, and De Carro. He has added to his work nu¬ merous examples of the beneficial erfedts which have re- fulted from their ufe in his own practice in private life, and in the great military hofpital Del Sagramento at Naples. Although fo recently introduced into that kingdom, it is at the prefent period very generally em¬ ployed and recommended by the principal profefl'ors in the capital and provinces. The author promifes fpeedily to produce a fecond volume, with additional obfervations and experiments on fumigations and vapour-baths, to¬ gether with two memoirs on the ufe of thermal vapour- baths, and on oily undtions. with artificial fumigation, as a preventive from, and cure for, the difeafes produced by the marlhy effluvia commonly known under the name of malaria" The remedies of which fignor Afialini treats, appear to have received but little attention in this country, although the extent of their employment in France, particularly the fulphureous fumigations in the treat¬ ment of cutaneous difeafes, have been long known, and their efficacy undifputed. We are not aware of the ex- iftence of any public inftitution for this purpofe in any part of the kingdom ; and the few private ones which have been eftabliffled are limited in their operation, and far from being fufficiently extended or perfedt. In addi¬ tion to this, where fuch eftablifflments exifi, the ex¬ penses neceffarily attendant upon their adminiftration are, indeed, fo great as almoft wholly to exclude the lower claffes of Society, for whom they are moft frequently necefiary, from the advantages to be derived from them. Our country has always been diftinguilhed far its cha¬ ritable inftitutions, and at no period more fo than the prefent. Without taking from the merits of thofe which already exift, we are convinced that few meafures would be more humane and beneficial to the community, than t‘he formation of fuch eftablifliments as we have fpoken of, for the prefervation of health, and more par¬ ticularly for the prevention and removal of cutaneous difeafes. We feel greatly allured, that fupport and af- fiftance from the public would be readily given, and that an effort, a commencement, only is wanting to fecure the execution of an objedt fo necefiary and lb advanta¬ geous. We omitted to notice, in its proper place, the Univer- fity and the Anatomical Mufeum of Stralburg. Of the Mufeum, an account, with a catalogue of the prepara¬ tions, was publilhed laft year (1820), by Profeffor J. F. Lobftein. This colledfion is divided into two principal fedtions, one of which contains thofe of the healthy, and the other thofe of the difeafed, ftrudture of the human fub- jebt, and of animals. In the firft, the organs are ar¬ ranged with a view to their phyfiology, by lyftems, and according to their different functions. The human or¬ gans, followed by the correfponding organs of animals, are contained and cla'fied in twenty compartments, which alfo include the preparations iifed for demonftration in the courfes of-anatomical and phyfiological ledtures. In the fecond, the organs, in a Hate of difeafe, occupy eigh¬ teen compartments, and are diftributed in an anatomical order, according to general fyftems, and according to the organs which belong to the fundlions of nutrition, rela¬ tion, and reprodudlion. The ofifeous fyltem may be ftudied with a view to com¬ parative anatomy, by the affiftance of the entire Ikeletons of fifty-three different animals, fifty-feven Ikulls, and a great number of bones, of every fpecies of animals. The colledfion of preparations which contributes to de- monftrate the ftrudture and formation of bones, is ex¬ tremely complete. Among many of thefe, the external and internal periofteum is beautifully injedted. The fine injedtions of foetal bones have alfo fucceeded equally well. The myological preparations are, at the tame time, connedted with the fubjedt of angiology, as they have been made from injedted fubjedts: by this means they have been rendered doubly inftrudtive. In addition to thefe, here are others of the foetus injedted for the pur¬ pofe of (bowing their ftrudture. Thefe preparations, when viewed by the affiftance of the microfcope, difplay a net-work of blood veffels fuperior perhaps to thofe in the colledfion of Prochafka. The preparations which relate to the fundtion of di- geftion are various and extenfive. The alimentary canal of the human fubjedt, from the commencement of the oefophagus to the anus, diltended with air and dried, is compared with that of fourteen kinds of animals, pre¬ pared in the fame way. The organs of digeftion of man in particular, commencing with the falivary glands, are contrafted with the correfponding organs of different animals. The minute anatomy of thefe parts has not been negledted. The inteltines are fo completely in¬ jedted, that the pupils can conceive a perfedt idea of their villous coat, as it has been diltended, and the papillae eredted by the refin of the injedtion. Portions of the inteftines of the foetus, the veffels of which have been injedted with ifinglafs, coloured white, are not inferior to the preparations of Lieberkulm. Twenty preparations of the lymphatic veffels elucidate the receptaculum chyii and the thoracic duel, the right lymphatic trunk, the ladteals of the mefentery well in¬ jedted, the lymphatics of the liver, the large plexufes of the pelvis and vertebral column; the lymphatic veffels of the lungs, thofe which pafs behind the fternum into the anterior part of the mediaftinum, and the fuperficia! and deep-feated lymphatics of the upper and lower ex¬ tremities. Though thefe preparations are fufficient to give pupils an idea of the lymphatic veffels in almoft all parts of the body, the abforbent fyftem is (fill every year injedted in the recent fubjedt, during the anatomi¬ cal ledtures. The fame is done with the other prepara¬ tions of minute anatomy, angiological and neurological, and thofe which relate to the organs of fenfe. The organs of refpiration, alter being examined in the human body, may be afterwards compared with the fimilar organs of quadrupeds, amphibious animals, and fifhes. The minute ftrudture of the lungs is rendered apparent, and efpecially the difpofition of the bronchial veficles, by preparations from the lungs of children. The larynx difplays the fuperior arid inferior laryngeal nerves on both (ides, traced to their moft minute branches. The thyroid gland is completely injedted ; and it is obferved, that this is one of thofe organs in which the injedtion, when urged into the arteries, returns moft readily by the veins. With refpedt to the nervous fyftem, here are perfedt injedtions of the pia mater, and, in fome inftances, even the cortical fubftance of the brain has been reddened. The injedtions of the nerves are not inferior to thole re- prefented by Reil, in his work, entitled Exercitationum Anatomicarum Fafciculus Primus, de Strudtura Nervo¬ rum. All the cerebral nerves, with their diftributions, 3 . are PATHOLOGY. are illuftrated by feveral preparations. Numerous re- fearches have been made upon the brain itfelf, the refults of which were publifhed in the tliird and fourth volumes of the Journal Complementaire du Diftionnaire des Sci¬ ences Medicales, The feftions of the brain, made ac¬ cording to the views and procefs of M. Lauth, are pre- ferved in acidulated water, which anfwers the purpofe better than any other liquid. The colleftion is equally rich in preparations of the organs of fenfe. With refpeft to that of touch, we may l'afely fay it is impoffible to carry the injeftion of the (kin farther than is done in thefe preparations: and that none can eafily be found lb inftruftive as thofe which relate to the ftrufture of the negro-fkin. The nerves of the tongue are traced to their minuted: branches. The pi- tuary membrane, fubjeftedto maceration after injeftion, fhows, in a very Superior manner, the net-work of rami¬ fications on this membrane. Among the preparations of the eye, we may notice the injeftions of the veffels of the choroid, of the retina, and of the canal of Fon¬ tana, by meVcury, &c. The organ of hearing is illuf¬ trated by a very large number of preparations, and its moft minute parts elucidated. As early as the year 1752, the old univerfity pofl’elTed a collection of fixteen prepa¬ rations of this organ, fo beautifully arranged by hinges, and other mechanical means, that the various partsof the organ may be ftudied both feparately and united, fo as .to fhow their relation to each other. Thefe, the refult of the great ingenuity of profeftor May, were prefented to the Royal Academy of Sciences at Paris ; and the Academy, in the hiftorical part of its Memoirs for the year 1734., has mentioned it in honourable terms. Thefe preparations, which they at prefent poffefs, have been iince augmented by the addition of eighty-feven others, worthy of the originals. The preparations which relate to the fexual fyftem of the male and female, to pregnancy, parturition, and the produfts of conception, amount to 182 in number. In the injections of the tefticle with mercury, the fluid in¬ troduced into the deferens has palled into the feminife- rous fubftance. In two fpecimens they' have fucceeded in the almolt entire development of the vas differens and epididymis. The injeCtion of the blood-veffeis of the tefticle with ilinglafs, coloured by cinnabar, has fuc¬ ceeded fo well, that not only the pulp of it has been reddened, but, by the help of a magnifying-glafs, a net¬ work of vefi’els can be diftinguilhed upon the veffels themfelves. A feries of fifty fcetufes (hows their gradual increafe, week by week, from the fecond month, up to the full term of pregnancy. Six preparations lhow the difpofition and development of the foetal organs at the different pe¬ riods of its life. The fecond feClion of this work, containing the pa¬ thological unatomy, forms a larger part of it than the preceding one 5 and we regret that our limits will not allow us to give fo complete an account of its contents as we could vvilh. We mull, therefore, confine ourfelves to noticing a few of its moft interefting objefts. Under the article of calculi, are mentioned fome of very unufual fize from the maxillary duCI. The col¬ lection of horfe-bezoar (inteftinal calculi) is alfo re¬ markable; the largeft weighs nine pounds and a half. The biliary calculi are arranged according to the claflification of Fourcroy : no clafs eftablillied by that chemift is wanting. The urinary calculi comprehend thirty-eight feries, a number of which, broken, or lawn, difplay their laminated ftrufture and the different co¬ lours of their ftrata correfponding to the three principal elements compofing them ; viz. uric acid, pholphate of lime, and oxalate of lime. Proftatic calculi, which are fomewhat rare, are to be feen difpofed in regular feries, or in a circular arrangement, in the excretory duCts of that gland. Calculi from veins, which the author calls phlebolithes, have been carefully collected and examined ; Vol. XIX No. 1288. 73 and a coloured reprefentation, which the author con- fiders unique, made of their laminated ftruflure. Under the article caries, a cranium is mentioned, which is perforated with apertures, in the form of a fieve, by a venereal afteftion. The patient from whom it was taken, was treated with mercury, and even now (as in 1758 when this preparation excited the attention of the curious) globules of mercury are feen in the little finus, and ulcers in the internal furface of the cranium. This faCt, obferved by Fallopius and others, had been denied in modern times, till fome experiments made at Tubin¬ gen in 1808, eftablilhed its truth. In a fpecimen of caries of the pelvis, the offa pubis et ifchii are entirely deftroyed, except the portion forming the fymphyfis of the former, and that which contributes to the formation of the acetabulum of the latter. M. Lobftein obferves, that it is not yet agreed what meaning is to be attached to the term J'pina venlofa. If fwelling of the bone in its whole thicknefs, and a fpon- ginefs of its texture, fuch as refults from cells of different dimenftons, may conftitute fpina ventofa; if the cells are filled with fluids of various kinds; if there are offeous excrefcences, either on the external furface, or within the above cells, the mufeurn contains fpecimens of this diforganization; particularly i:i the os humeri, tibia, and fibula. The laft form of the difeafe of bone noticed, is that in which large maffes of offeous matter entirely difappear, and no traces of them are found, except infulated frag-, roents floating in an abundance of mucilaginous matter. The author firft noticed this difeafe in the ribs, and de- fcribed it with other analogous examples in the “ Rap¬ ports fur les Travaux executes a l’Amphitheatre d’Ana- tomie.” Since the publication of that, he has obferved it a fecond time on the ribs and pelvis of the fame indi¬ vidual. The facrum and offa innominata were covered with a thick periofteum, more moift than ufual ; in de¬ taching it, the compaft external table of the bones could be at once removed : a reticular tiffue was then feen with larger interftices, which were filled with a fubftance in colour and confidence very like currant-jelly. This difeafe, in the opinion of M. Lobftein, confilts in a fpon- ginefs of the bone, accompanied by a fecretion of an albumino-mucous matter. In the fluid of the numerous cyfts, which fupplied the place of the offeous matter de¬ ftroyed, portions of bone, rendered thin and porous, were feen floating like half-diffolved fugar. The conti¬ guous portions of bone had the fame fpongy appearance. In fpeaking of the organic changes of mufcles, their conversion into fat, to which the term Myodemie is given, is faid to have been obferved in two inftances. In another the femi-membranofi alone had undergone this change. After fome remarks on the fympathetic coinci¬ dence in the deficiences and difeafes of the mufcles of the two fides and extremities of the body, the author relates a cafe in which the biceps of each arm, and no other part, was found in a date of gangrene, in a woman who died in child-bed. The morbid changes, &c. of the vafcular fyftem, are contained in the next chapter, from which we (hall only mention a rare diftribulion of the aorta: its arch divides into two branches, which, by their reunion, form a fpace, and through this pafs the trachea and thecefopha- gus.' The irregularity is defcribed by Hommel, in the Commerc. Lit. Noricum. 1777. The remaining chapters are devoted to the pathological anatomy of the thoracic organs, thofe of digeftion, of the urinary fyftem, nervous and generative fyftems. Like the reft of the book, they are made up of a mafs of va¬ luable and interefting fafts, ftated with the utmoft fim- plicity and clearnefs. Laft of all is placed a Catalogue of the Preparations of this deleft yet extenfive Mufeum. The whole number of them amounts at prefent to 3286, of which 1977 relate to phyfiological, and 1309 to pa¬ thological, anatomy. The Mufeum is open to the public U once 74 PATHOLOGY. once every week ; ftudents have accefs to it daily ; and, with a liberality ft ill more worthy of praife and of imi¬ tation, foreigners are admitted at all hours, and at the firft application. It is with aftonifhment we learn, that only fifteen years have been fpent in the accumulation of this admirable collection : for, in 1804, there were only 2u preparations. The very complete Mufeum of Berlin, colt: its founder, profeffor Walter, fifty-four years in its collection ; but it contains not more than 2268 preparations. Three hundred bodies are annually at the difpofal of the faculty of Stralbourg. Such noble encouragement and opportunities of obfervation ; the co-operation of the profeffors and the practitioners of the town, who tranfmit, as to a common centre, the refult of their par¬ ticular pathological examinations; the rare and curious objeCts which flock from the neighbouring country; the intelligence and zeal of the profeCtors and ftudents ; all thefe circumliances combined, lead us to expeCt from this quarter ftill greater contributions to medical fcience. Since we have travelled out of Germany; and got again into France, vve {hall detain the reader a few minutes while we defcribe the prefent ftate of the obftetrical art in that kingdom ; which we are enabled to do by the very recent publication (1821) of the “Pratique des Accouchemens,” by a real mi dzcife, Madame Lachapelle, chief operator at the Lying-in Hofpital at Paris. This volume is one to which we have nothing fimilar in this country. It is the production of a female prac¬ titioner, placed by public authority in a molt important official fituation ; and is no lefs defervingof notice from the rare occurrence of fuel) publications, than from the juft views and accurate criticifms on the ftate of the fcience on which it treats. But thefe are fubjeCts on which it is not at prefent our intention to dwell, as we are inclined rather to take the opportunity of pointing out the ftate of public inftruCtion in this fcience in France, and to contrail it with the deficiency in this point, which all mull admit and lament as exifting in this country. From time immemorial, the only afylum afforded by the city of Paris j:o puerperal women, was a miferable ward in the Hotel-Dieu ; a principal midwife, with five or fix pupils, whofe ftudies lafted but for three months, ill fufficed for the number of births which occurred. The place was ftill more inadequate; the women admit¬ ted were heaped together, and commonly feveral lay at the fame time in one bed. Thefe inconveniences were of fo ferious a nature as to attradl the attention of the govern¬ ment. In the year 4 of the Republic (1797), the National Convention decided on building a houfe for theparticular purpofe of receiving parturient women. Madame La¬ chapelle, in conjunction with her mother, the principal midwife of the Hotel-Dieu, was charged with the direc¬ tion of the fervice of the new inftitution. The difpo- iitions for the arrangement and order of the whole efta- blifhment were formed in concert; and it is thus that the plan originally laid down has been more extenfively applied. The number of pupils as midwives has fince pone on increafing, as well as the number of individuals admitted. The former at prefent amount to 130 an¬ nually. This increafe, as well as the organization of the fchool, was owing to M. Chaptal, then minifter. M. Baudelocque was then made profeffor, and affilted to render the work more perfedt. M. Dubois, who l'uc- ceeded him, has preferved the order adopted by his pre- deceffor, which we proceed to defcribe. The pupils admitted at the School of Midwifery are expedted to employ themfelves as well with the relief of the patients as with their own perfonal inftruCtion : fuch, in fadt, is the principal objedt in view. This neceffity forces them to a practical ftudy, to which, in particular, they are indebted for their acknowledged Juperiority over the pupils of every other fchool. All pafs a w hole year at the hofpital ; and about a fourth part of their number twice this period, ferving in the fecond year to direCt the new pupils. The newly-arrived pupils are fe- parated into as many divifions as there remain old pupils who double the period of their flay. Thefe laft direCt the divifion entrufted to them, affift at funple labours, and point out to their companions the particularities of examination, &c. . The patients admitted are firft examined by the prin¬ cipal midwife, wdio rejeCts or retains them according to circumliances. The period fixed is the end of the eighth month. Simple deliveries are all performed by the pupils, in the prefence of the divifion, and under the direction of the elder one, who ferves as chief. Each pupil has the fubfequent care of the woman whom fhe has deli¬ vered. On the occurrence of the leaft difficulty, the principal midwife is called in. If the ufe of inftruments fhould be required, it is fhe who operates ; if the deli¬ very .be difficult, although the hand alone fuffices, fire ftill has the charge of it; but eafy manual deli veries are terminated, under her infpeCtion, by one of the old pupils, fo that almoft all have, before the end of their fecond year, performed an artificial delivery. Very com¬ plicated cafes, fuch as require the ufe of a cutting inftrument, call for the prefence of the profeffor. Peritonitis too often prevails in the wards : a hoft of other difeafes may alfo attack parturient women. It is then that, after being carried to the infirmary, they are entrufted to the care of the experienced and learned pro¬ feffor Chauffier, principal pbyfician. Under his infpec- tion, feveral female pupils note daily, and with 1110ft fcrupulous exaClr.efs, the fymptoms, periods, termina¬ tion of the difeafes, and the effeCts of remedies; they thus become accuftomed to recognize danger, to prevent it, and, if not to remove it, at leaft to have recourfe early to the affiftance of medicine. Three times in thg week the profeffor explains the theory of the fcience of midwifery. A lecture is given every day by the principal midwife ; and a fimilar one by Mademoifelle Hucherard, for eight years acquainted with the principles of the art, and honoured with the title of “ principal pupil,” wdio alfo exercifes the others on the model, in the ufe and application of inftruments. Amongft the old pupils, thofe who have molt facility in expreffing themfelves, and capacity for inftrudtion, are charged with giving re¬ petitions to the new comers, of the lectures of the pro¬ feffor, the midwife, and principal pupil. Amidft all thefe attentions to the principal objedt, the acquifition of acceffory knowledge is not negledted. Under the di¬ rection of the principal phyfician, the apothecary lays down to the pupils the general principles of botany, and makes them acquainted with the molt important plants and drugs. In the fame manner the leudent in medicine attached to the inftitution makes fome demonftrations on general anatomy, on that of the vifeera, on the principal functions, on the mufcles of the abdomen, and, laftly, on vaccination and venaefeCtion. For thefe two opera¬ tions the inftrudtions are not folely theoretical ; the pu¬ pils bleed and vaccinate as often as there is an opportu¬ nity, but alw’ays in the prefence of the ftudent in medi¬ cine. Such are the means of inftrudtion prefented to the pupils in midwifery; the wifdom of the adminiftration lias added ufeful encouragements. At the end of each fcholaftic year, feveral prizes are given by competition, on fubjedts relating to the fcience of midwifery ; the principal is a golden medal: prizes are alfo given for clinical vigilance, the obfervation of patients, the ftudy of botany, and for vaccination. It is a circumftance perhaps only to be underftood by the confideration of the inconfiftency of human proceed¬ ings, that, while laws and regulations were early devifed for the protedtion of the public from the pretentions of the ignorant and unprincipled in the pradtice of medicine and lurgery, midwifery, a fcience connedted as it is with the tendereft feelings and belt interefts of fociety, fhould be left in the hands of the loweft and moft uninformed people, PATHOLOGY. people, at lead as far as it regards the great mafs of the public in every country. Nor has this delufion been confined merely to the carelefs and indifferent obferver ; even thofe whom their abilities might have been ex¬ pected to have exempted them from the errors of common minds, feem but too often to have thought, that infor¬ mation on difficult and complicated fubjeCts might be acquired, as it were, intuitively; and that mechanical unobferving experience might fupply the defeat of early and well-grounded inftruCtion. It needs but little either of intellect or inquiry, to fee at once the fallacy and ab- furdity of fuch an idea. We are aware that at the prefent period, in this country, a confiderable portion of the male practitioners in midwifery, are individuals whofe compulfory profeffional education may be fairly fuppofed to render them ade¬ quate to the performance of the duties they undertake; but it is notorious that fuch is not the cafe with the fe¬ males, on whofe care and (kill the lives or the future comfort of women in the lower claffes of life, and in re¬ mote parts of the country, are fo completely dependent. Nor can it be unknown, that in every part of the king¬ dom, even in the metropolis, no fecurity exifts againft the ignorance of thofe who may choofe to enter upon the praCtice of this molt important branch of the healing art ; that an acquaintance with, or courfe of inllruCiion in, its principles, forms no part of the qualifications required by the three corporate bodies, whofe members and li¬ centiates form the greater part of private practitioners in England. Nay, on the contrary, at leaft two of thefe are more difpofed to difcourage than to countenance the extenfion of this divifion of practice amongtheir members. After an attentive confideration of the difficulties and the inconveniences we have alluded to, it furely requires no argument to convince every uninterelted individual, whether profeffional or othervvife, of the neceffity for fame regulation of this branch of the profeffion, and of the important advantages which would accrue to the public from the organization of a clafs oi female practi¬ tioners, well qualified for the performance of the duties they are intended to difcharge. To the inftitution of fuch a clafs in this country, we can fee no well-founded or difinterefted objection ; and it mult be allowed that nothing feems better adapted to attain the objeft in view than the fyftem which has received fo ample a trial in France, and of which we have given an account. Of this at leaft we feel convinced, that a trial only is re¬ quired to exhibit its excellence, and enfure its adoption. Should fuch a plan be ever put in execution, it would doubtlefs be moil advantageous to combine its employ¬ ment, as has been done in France, with the internal ma¬ nagement of the lying-in inftitutions already in exiftence, efpecially in the metropolis. But here we mull check ourfelves, as it muft be confeffed, that it is much more eafy to proclaim the exiftence of defeCts than to apply appropriate remedies, and as it is far from being our in¬ tention to affume.a talk that we hope to fee in more com¬ petent hands. Greece and Turkey. — In turning to the confidera¬ tion of Greece, the land of heroifm and claffic recollec¬ tions, we find that 3000 years have glided over without any improvement in medicine beyond the practice of the Father of Medicine. Indeed in many inftances we might almoft wiffi that the practice of Hippocrates only was followed, without variation or improvement ; but the phy- iicians of Greece and of Turkey are much occupied in difcuffing the theories of Brown or of Boerhaave ; and, though occafionally a flaffi of ancient fire and of the true philofophy of the priftine Hellenian has animated the Greeks, yet the major part are contented with thefe vain and fruitlefs enquiries. This ftate will not probably laft long : the defpotic government of the Turks may be confidered as the caufe of the long fupinenefs of the Greeks ; and, whether the ftruggle for their indepen¬ dence be l'uccefsful or not, a fpirit of emulation and en¬ 75 quiry exifts at prefent in that nation, which cannot fail of producing much advantage to philofophy. Of the mode of vifiting and treating patients in Turkey, an amuling account is given by Dr. Neale, late phyfician to the Britifh embaffy at Conftantinople. After adverting to the belief of the Turks in predefti- nation, Dr. N. proceeds thus. “ Still, fatalifm and apathy have their limits; and the proud infidel, in the hour of ficknefs, does not difdain to invoke the affiftance of the Giaour to delay the approach of death. Of this I had a memorable inftance within a few days after my arrival at Terapia, when, very unexpectedly, I received a meffage from the emperor Selim the Third, to vifit his mother the fultana Valide. Mr. Pifani, the fenior dra¬ goman (interpreter), was the bearer of this requeft; and the following morning I fet off by water for the feraglio, accompanied by one of the junior dragomans. We were put affiore at a quay near Baktchi Capouffi, where we found a boftanji in waiting, to conduit us to the houfe of the principal court-phyfician, who lived in a narrow ftreet adjoining the wall of the feraglio. On arriving there, we were informed that he had already gone to fee his patient, having left inftruCtions that we ftiould follow him, which w'e did, entering the gardens by the little white gate near the chapel of St. Irene. We palled a guard-houfe of boftanjies on our left, and then proceeded under an avenue of lofty cyprefs-trees, towards a fecond guard-houfe, whence we were conduced to a detached pavilion, in which wefound theHekitn Balha, or Turkilh phyfician, Mahmoud Eft’endi ; a Greek phyfician, named Polychronon ; the Kiflar Agaffi, a hideous Ethiopian, the chief of the black eunuchs; the Hazni Vekili, alio a black eunuch, keeper of the privy purfe; and fome der- vifes and muftis. After being introduced, and going through the ufual routine of pipes, coffee, Iherbet, and fweetmeats, Polychronon, converfing in Latin, entered into a detailed ftatement of the malady with which the fultana was afflicted, namely, an inveterate quartan ague, of upwards of eighteen months’ ftanding. From this ffie had recovered more than once ; but had relapfed as often, owing, in part, to her own want of due caution, and to the officious interference of a fet of muftis who befet her, and forced upon her large draughts of iced water, in which they immerfed talifmans, alluring her that they would eftablilh her convalefcence ; but, on die contrary', thefe draughts invariably brought back the cold fits of her ague. Upon the laft relapfe, fome days before I faw her, Hie had, during the cold paroxyfm, been fuddenly bereft, in her lower extremities, of all power of motion and fenfe cf feeling; and it was upon this point, and fome others alfo, that my opinion was requefted. Indeed I w'as to decide, as I found, between three of her phy- ficians who called themfelves Boerhaavianx, and four others who profefled themfelves firiCt Brownonians, as to the expediency of preferibing a cathartic medicine; the former preffing the abfolute neceffity of fuch a remedy after five days’ conftipation, and the latter moft fooliftiiy declaring it to be perfectly inadmiffible, according to their interpretation of the doCtrine of Brown. This being premifed, we all accompanied the Kiflar Agaffi to an adjoining kiolk, in which was the fultana. After ex¬ changing my fhoes at the door fora pair of yellow flip¬ pers, we entered the royal apartments. On a mattreis, in the middle of the floor, was extended a figure covered with a filk quilting, richly embroidered. A female figure veiled was kneeling at the fide of her pillows, with her back towards the door of entrance ; and the Kiflar Agaffi beckoned to me to kneel down by her fide, and examine the pulfeof the fultana. Having complied with this requeft, I expreffed a wiflnto fee her tongue and countenance; but that I was given to underhand could not be permitted, as I muft obtain that information from the report of the chief phyfician. The moft profound filence was obferved in the apartment, the eunuchs and phyficians converfing only by figns. The Hazni Vekili then / 76 PATHOLOGY. then took me by the arm, and turned me gently round, with my face towards the door of the entrance, over which was a gilded lattice, concealing the emperor, who had placed himfelf there to witnefs the vifit. Our flay in the room did not exceed fifteen or tw enty minutes. The four large windows were fhaded externally by gilded lattices, and the intervening pannels were covered with mirrors and arabefque tapeltry. The divan, which en¬ circled the chamber, was veiled with crimfon cloth, richly embroidered with gold, furrounded with culhions of the fame defcription ; and the floor was covered with a fuperb Perfian carpet. On our return to the firft pavilion, I, of courfe, coincided with the Boerhaavians, and wrote a prefcription to that effeft. Indeed, had (he been a princefs of any other European court, it is probable that a large bleeding would have been decided upon ; but, from the ignorance and prejudice of her attendants, I found it impoflible to convince them of its neceflity ; and on confidering that the miftakes, real or imaginary, of the Turkifh court-phyficians, are frequently vifited by the bow-ftring, I had but little inclination to bring the lives of my colleagues into farther jeopardy. The He- kim-Bachi and Hazni Vekili therefore carried my pre¬ fcription, and interpreted it to the fultan, who, in re¬ turn, fent back a complimentary mefiage, and a purfe con¬ taining one hundred and fifty fequins.” In cafe our readers fltould feel interefted in the fate of the patient, w'e mult add, that the fultana funk under her illnefs in the courfe of a week: but her age was fe- venty-two ; and her Ion, far from giving way to the bar¬ barous practice of punilhing the court-phyfician, figni- fied to him that the event; was evidently in the courfe of nature, and fltould make no alteration in the confidence which he enjoyed. This prince, deferving of a better fate, was the unfortunate Selim who loft his life by an infurreftion of the Janiflaries in 1807. GENERAL PATHOLOGY. In the prefent philofophic age, it appears needlefs to difcufs the propriety and neceflity of being guided by reafon in our pathological inveftigations. Very few pro- feflional gentlemen will now be found ftri&ly empirical ; and thofe few are among the leaft honoured and lead de¬ ferving in our profeflion. There is fomething in the human mind fo prone to enquire into the caufe why, and the reafon wherefore, that the verieft empiric in the prac¬ tice of phyfic will never be contented with attaching himfelf to fafts, as he profefles, without regard to infe¬ rential reafoning. There is fomething fo gratifying to one’s love of fcience, fomething which fo evidently leads to better information, even in the vagueft explanation of natural phenomena, that we cannot be furprifed that it has been attempted in all ages. Yet, in the courfe of our hiftory of medicine, we have had frequent occalion to fhow how fatal has been the refult of too much theory. Independently, however, of the circumftance that what is injurious to the progrefs of fcience in its infant ftate, may ceafe to become fo when it is more advanced, we have found hitherto no fyftem of medicine which has fufflciently accounted for all morbid phenomena, or in which many huge gaps and deficiences have not been filled up by gratuitous afler- tions. In the infant ftate of medicine there can be no doubt that theory often exerted a moft decided influence on that fcience. But the paucity of fafts, the data whence the theories of the ancients were framed, were the caufe ©f their frequent errors. They were like labourers at¬ tempting to build a lofty palace with a few ftones. In our own time, however, we have fo far advanced in the ac¬ cumulation of fafts, that, though much remains to be done, we are' compelled in fome meafure to generalize and fyftematize our knowledge, which elfe would become too burthenfome for memory. To follow up our fimile, we may be faid in our own time to be in pofleflion of materials fufflcient forbuilding a liable edifice ; and hence we may now look forward to the eftablilhment of a fyftem which, to ule the arrogant expreflions of Darwin “may not moulder, like the ftruffures already erected, into the fand of which they w'ere compofed, but which may (land unimpaired like the Newtonian Philofophy, a rock arnid the wafte of ages.” We (hall not paufe here to enquire into the utility of fyftems of medicine. Our periodical medical publications have lately raifed much uproar againft fyftems. It mull be obvious to every one, however, that a feries of dry in- fulated fadils, or of reafonings applicable only to a limited number of phenomena, can never be fufflciently remem¬ bered, or indeed perfectly known. Provided, therefore, we wander not into the mazes of hypothefis, provided our analogies are not forced, or our claflifications likely to lead to erroneous methods of praftice, it mull be al¬ lowed that we are advancing our knowledge, clearing away many erroneous notions, and reconciling many contradiilory opinions, by. taking general and extended views of difeafe. See vol. xvii. p. 24.5. We have faid that the knowledge of the ftru£lure and funftions of man ftiould precede the ftudy of pathology. Of the animal ftrufture we have given an ample account in the firft volume of our work, under the article Ana¬ tomy; of the fecond w'e propofe to treat under the ar¬ ticle Physiology. In the mean time, the more clearly to develope the opinions we have adopted, it will be ne- ceflary to give a fliort flcetch of the economy of man, and of the moll prominent fyftems and moft important ftruc- tures which belong to his organization, the better to un- derftand in what difeafe a deviation from this ftate con- fifts. In the organization of man, then, the firft fyftem to be conlidered is the nervous. It confifts of the cranial brain, the fpinal marrow, nerves, and ganglia. By means of this fyftem, all mental emotions are communicated to the other parts of the animal frame, and, through its medium, all external impreflions are communicated to the mind. We obferve likewife a fibrous ftrufture of different kinds in various parts; as mufcular, offeous, See. the molt ge¬ neral and important of which are the mufcular ones. To thefe is added a fundamental cellular ftrudture, which ap¬ pears to tonneft all parts of the other fyftems together; and which has various appearances in regard todiverfity of fubftance, and indeed in regard to the lecretions derived from it. The union of thele three fyftems takes place in various modes : in fome cafes in tubes, or on membranes, &c. &c. and the more remarkable of thefe unifons may be aptly divided into the digeftive, refpiratory, fanguife- rous, fecernent, and abforbent, fyftems; and this phyfiolo- gical divifion we have taken as the bafis of our arrange¬ ment, which agrees with the excellent one lately made by Dr. Good, in his Phyfiological Syltem of Nolology. Many objeftions have been made however to all the prefent arrangements; the moft important of which is, that, by allowing the attention of the medical praftitioner to be exclufively direfled to one fyftem or to one organ, it prevents that due attention being paid to morbid cate¬ nations, which the practice of phyfic imperioufly de¬ mands. There is nothing, however, in the nature of nofology which renders this error a'venial one. It mull be allowed that morbid impreflions are generally primarily made on one particular tilfue or organ; and it mull be allowed too, that a fyftem which is lecondarily affected, often fuflers the moft feverely ; or that the fyftem fecon- darily affedled may be the moft important to life, and hence our attention ftiould be chiefly directed towards it. We will venture to affert, that whoever has afliduoufly ftudied the ftrudfureof parts and their phyfiology, cannot fall into the error of confining his attention to one part of the animal economy to the exclufion of the reft. To render this more plain, we (hall proceed with fome further account of the adlion of the different fyftems above mentioned upon each other. If the animal frame 3 were PATH people, at lead as far as it regards the great mafs of the public in every country. Nor has this delufion been confined merely to the carelefs and indifferent obferver ; even thofe whom their abilities might have been ex¬ pected to have exempted them from the errors of common minds, feem but too often to have thought, that infor¬ mation on difficult and complicated fubjeCts might be acquired, as it were, intuitively; and that mechanical miobferving experience might fupply the defeCt of early and well-grounded inftrudtion. It needs but little either of intellect or inquiry, to fee at once the fallacy and ab- furdity of fuch an idea. We are aware that at the prefent period, in this country, a confiderable portion of the male pradtitioners in midwifery, are individuals whole compulfory profeffional education may be fairly fuppofed to render them ade¬ quate to the performance of the duties they undertake ; but it is notorious that fuch is not the cafe with the fe¬ males, on whofe care" and fkill the lives or the future comfort of women in the lower claffes of life, and in re¬ mote parts of the country, are fo completely dependent. Nor can it be unknown, that in every part of the king¬ dom, even in the metropolis, no fecurity exifts againft the ignorance of thofe who may choofe to enter upon the practice of this molt important branch of the healing art ; that an acquaintance with, or courfe of inftrudtion in, its principles, forms no part of the qualifications required by the three corporate bodies, whofe members and li¬ centiates form the greater part of private pradtitioners in England. Nay, on the contrary, at leaft two of thefe are more difpofed to difcourage than to countenance the extenfion of this divifion of pradtice amongtheir members. After an attentive confideration of the difficulties and the inconveniences we have alluded to, it furely requires no argument to convince every uninterefted individual, whether profeffional or otherwife, of the neceffity for fome regulation of this branch of the profeffion, and of the important advantages which would accrue to the public from the organization of a clafs of female prufti- tioners, well qualified for the performance of the duties they are intended to discharge. To the inftitution of fuch a clafs- in this country, we can fee no well-founded or difinterefted objedtion ; and it mult be allowed that nothing feems better adapted to attain the objedt in view than the fyftem which has received fo ample a trial in France, and of which we have given an account. Of this at leaft we feel convinced, that a trial only is re¬ quired to exhibit its excellence, and enfure its adoption. Should fuch a plan be ever put in execution, it would doubtlefs be molt advantageous to combine its employ¬ ment, as has been done in France, with the internal ma¬ nagement of the lying-in inftitutions already in exiftence, efpecially in the metropolis. But here we muft check ourfelves, as it muft be confefi'ed, that it is much more eafy to proclaim the exiftence of defedts than to apply appropriate remedies, and as it is far from being our in¬ tention to afi'ume a talk that we hope to lee in more com¬ petent hands. Greece and Turkey. — In turning to the confidera¬ tion of Greece, the land of heroifin and claffic recollec¬ tions, we find that 3000 years have glided over without any improvement in medicine beyond the pradtice of the Father of Medicine. Indeed in many inltances we might almoft wiffi that the pradtice of Hippocrates only was followed, without variation or improvement ; but the phy- ficians of Greece and of Turkey are much occupied in difcuffing the theories of Brown or of Boerhaave ; and, though occafionally a flalh of ancient fire and of the true philofophy of the priltine Hellenian has animated the Greeks, yet the major part are contented with thefe vain and fruitlefs enquiries. This ftate will not probably laft long: the defpotic government of the Turks may be confidered as the caufe of the long fupinenefs of the Greeks ; and, whether the ftruggle for their indepen¬ dence be fuccefsful or not, a fpirit of emulation and en¬ voi.. XIX. No. 1288. O L O G Y. 75 quiry exifts at prefent in that nation, which cannot fail of producing much advantage to philofophy. Of the mode of vifitingand treating patients in Turkey, an amuling account is given by Dr. Neale, late phylician to the Britilh embaffy at Conftantinople. After adverting to the belief of the Turks in predefti- nation. Dr. N. proceeds thus. “ Still, fatalifm and apathy have their limits; and the proud infidel, in the hour of ficknefs, does not difdain to invoke the affiftance of the Giaour to delay the approach of death. Of this I had a memorable inftance within a few days after my arrival at Terapia, when, very unexpectedly, I received a meffage from the emperor Selim the Third, to vifit his mother the fultana Valide. Mr. Pifani, the fenior dra¬ goman (interpreter), was the bearer of this requeft ; and the following morning I let off by water for the feraglio, accompanied by one of the junior dragomans. We were put affiore at a quay near Baktchi Capouffi, where we found a boftanji in waiting, to conduCt us to the houfe of the principal court-phyfician, who lived in a narrow ftreet adjoining the wall of the feraglio. On arriving there, we were informed that he had already gone to fee his patient, having left inltruCtions that we ffiould follow him, which we did, entering the gardens by the little white gate near the chapel of St. Irene. We paffe.d a guard-houfe of boftanjies on our left, and then proceeded under an avenue of lofty cyprefs-trees, towards a fecond guard-houfe, whence we were conducted to a detached pavilion, in which we found theHekim Baffia, or Turk.ifti phyfician, Mahmoud Eftendi ; a Greek phyfician, named Polychronon; the Kiflar Agaffi, a hideous Ethiopian, the chief of the black eunuchs; the Haz.ni Vekili, alfo a black eunuch, keeper of the privy purfe; and fome der- vifes and muftis. After being introduced, and going through the ufual routine of pipes, coffee, fherbet, and fweetmeats, Polychronon, converfing in Latin, entered into a detailed ftatement of the malady with which the fultana was afflicted, namely, an inveterate quartan ague, of upwards of eighteen months’ Handing. From this (he had recovered more than once ; but had relapfed as often, owing, in part, to her own want of due caution, and to the officious interference of a fet of muftis who belet her, and forced upon her large draughts of iced water, in which they immerfed talifmans, alluring her that they would eftablilh her convalefcence ; but, on the contrary, thefe draughts invariably brought back the cold fits of her ague. Upon the laft relapfe, fome days before I faw her, (he had, during the cold paroxyfm, been fuddenly bereft, in her lower extremities, of all power of motion and fenfe of feeling; and it was upon this point, and fome others alfo, that my opinion was requefted. Indeed I was to decide, as I found, between three of her phy- ficians who called themfelves Boerhaavians, and four others who profeffed themfelves drift Brownonians, as to the expediency of prefcribing a cathartic medicine; the former preffing the abfolute neceffity of fuch a remedy after five days’ conftipation, and the latter moft foolifhly declaring it to be perfectly inadmiffible, according to their interpretation of the doCtrine of Brown. This being premifed, we all accompanied the Kiflar Agaffi to an adjoining kiolk, in which was the fultana. After ex¬ changing my (hoes at the door fora pair of yellow flip¬ pers, we entered the royal apartments. On a mattrefs, in the middle of the floor, was extended a figure covered with a filk quilting, richly embroidered. A female figure veiled was kneeling at the fide of her pillows, with her back towards the door of entrance; and the Kiflar Agaffi beckoned to me to kneel down by her fide, and examine the pulfeof the fultana. Having complied with this requeft, I exprefled a wifli to fee her tongue and countenance; but that I was given to underlie nd could not be permitted, as I muft obtain that information from the report of the chief phyfician. The moft profound filence was obferved in the apartment, the eunuchs and phyficians converfing only by figns. The Hazni Vekili X then 76 PATHOLOGY. then took me by the arm, and turned me gently round, with my face towards the door of the entrance, over which was a gilded lattice, concealing the emperor, who had placed himfelf there to witnefs the vifit. Our ftay in the room did not exceed fifteen or twenty minutes. The four large windows were ffiaded externally by gilded lattices, and the intervening pannels were covered with mirrors and arabefque tapeftry. The divan, which en¬ circled the chamber, was veiled with crimfon cloth, richly embroidered with gold, furrounded with cufhions of the fame defcription ; and the floor was covered with a fuperb Perfian carpet. On our return to the firft pavilion, I, of courfe, coincided with the Boerhaavians, and wrote a prefcription to that effect. Indeed, had ffie been a princefs of any other European court, it is probable that a large bleeding would have been decided upon ; but, from the ignorance and prejudice of her attendants, I found it impoflible to convince them of its neceflity ; and on confulering that the miftakes, real or imaginary, of the Turkifli court-phyficians, are frequently vifited by the bow-Aring, I had but little inclination to bring the lives of my colleagues into farther jeopardy. The He- kim-Bachi and Hazni Vekili therefore carried my pre¬ fcription, and interpreted it to the fultan, who, in re¬ turn, fent back a complimentary meffage, and a purfe con¬ taining one hundred and fifty fequins.” In cafe our readers ftiouid feel interefled in the fate of the patient, we mull add, that the fultana funk under her illnefs in the courfe of a week: but her age was fe- venty-two ; and her 1'on, far from giving way to the bar¬ barous practice of punifliing the court-phyfician, figni- fied to him that the event was evidently in the courfe of nature, and (hould make no alteration in the confidence which he enjoyed. This prince, dei'erving of a better fate, was the unfortunate Selim who lofl his life by an infurreftion of the Janiflaries in 1807. But at length we have better news to communicate, and fiuch as will be highly gratifying to our readers. For we think that all who intereft themfelves in the progrefs of fcience, and more particularly in that of medicine, cannot but feel pleafure in learning that in Turkey, a part of the world where knowledge has hitherto made the molt inconfiderable advancement, where every thing is under the dominion of prejudice, and the moft: bene¬ ficial fuggeftions are oppofed with the moft obftinate ani- mofity, the government has lately caufed to be compofed and printed in the vernacular language, the firft work on anatomy and medicine which has been produced by the prefs at Conftantinople. Whether we confider the aver- fion entertained by the Turks for the moft ufeful know¬ ledge which does not accord with the fpirit of the Koran, or which is derived from Chriftians ; or their implicit obedience to the oulemas, or priefts, whofe intereft and policy have uniformly prompted them as much as poflible to enflave and paralyze the national mind 5 this revolu¬ tion in the opinions of Muffulmen appears in an equal degree extraordinary. The only ftep which the Turks have taken in civiliza¬ tion for the laft century has been the adoption of print¬ ing, (firft introduced at Conftantinople fo lately as 1726.) but this improvement was fall lofing its beneficial effefts till the reign of the unfortunate Selim III. juft mentioned, who fomewhat revived the declining ftate of dawning literature. But the prejudices and religious fcruples againft every kind of reprefentation of human figures; the religion which forbids the contafl of blood, as a pollution; the law* againft the opening of bodies ; and, laftly, the belief in predeltination, which ranks im¬ providence and indifference to the accidents of life among religious virtues ; all thefe, by their combined operation, afforded, till the prefent time, infurmountable barriers to the progrefs of anatomy and furgery. From all thefe ob- ftacles then, the work of which we are about to give an account, cannot fail to excite general attention, and to conftitute an epoch in the hiftory of the Ottoman Empire. This volume, printed at Conftantinople in the Turkifli language, contains about 300 folio pages; and, what is more particularly worthy of notice, it is accompanied by fifty-fix indifferently-engraved plates, in which the hu¬ man figure, and the various objefrs of anatomy, are de¬ picted. The greater part of it has been copied by the author, Chani-Zadeh Mehemmed-Ata-Oullah, from fo¬ reign productions of a fimilar nature. According to fome communications made to M. Bianchi by a perfon lately arrived at Paris from Conftantinople, this Muffulman muft be the foil of an old and principal phyfician of the government, whom his father fent to Italy for the pur- pofe of profecuting his ltudies, and who at his return immediately engaged himfelf in writing on anatomy and furgery. The principal phyfician of government, called in the Turkifli language Hekirn Bajha, arrives at his dignity after having filled the office of cadi, or judge; and is chofen from the religious or judicial officers. It is only when he has arrived at the end of his career, and at the rank to which all his colleagues may afpire, that he is nominated as the chief phyfician of the empire, without having undergone any medical education which could entitle him to the office. He has, therefore, at the fame time to fulfil the duties of his other employment, and to direCt his attention to the ltudy of medicine and fur¬ gery, a circumftance which will enable us to judge of his neceflarily-limited acquaintance with the knowledge re¬ quired for the exercife of his new profeffion ; though he is ex-officio at the head of the medical department in the empire; as the phyficians, furgeons, and druggifts, fub- jeCt to the Grand Signior, are nominated by the principal phyfician of government, a fource from which he derives a confiderable revenue. M. Bianchi obferves that, notwithftanding the preju¬ dices, or rather the fuperftitious refpeCt, of the nation for ancient cuftoms, many individuals are to be found among the public officers, who have a fufficient degree of intelligence to induce them to countenanceimprovements calculated for the general good. He was more particularly led to make this remark, at the time of the plague in the year 1811-12, when he was commiflioned by the French conful to tranfiate into Turkilh the inftruCtions con¬ tained in the work of Guyton-Morveau, on the means of deftroying the infeClious properties of air by the aid of chlorine. The tranflation was put into the hands of the governor of Smyrna, and was received with equal pleafure and gratitude. The method was not only at once adop¬ ted by him, both as an antidote againft infection, and a means of purifying contaminated apartments and goods, but he alfo ordered its adoption by all the members of his family, at that time engaged in the principal adminiftra- tions of Smyrna, as well as by the Greek and Armenian communities of the fame city. However latisfaftory and beneficial the plan may be, it is at prefent highly probable, that the tragical death of the governor, which took place in 1817, by order of the Grand Signior, and the difgrace of all his family, will plunge into oblivion not only the plan itfelf, but alfo the falutary effedls by which it was followed; a refult which is inevitable in a nation, among whom inftruflion and information are not general, and men, difpofed to protect the interefts of fcience, have only an ephemeral exiltence. It is very much to be wiffied, that this firft appearance of a tafte for medicine and furgery, by becoming more general in the Eaft, may produce phyficians in that part of the world, who would be better calculated than the prefent race, to affume the guardianfhip of the public health ; for, with the exception of fome foreigners at Conftantinople, and the other towns of the Levant, who acquit themfelves with reputation in their profeffion, the whole empire is infefted with a mob of charlatans and ad¬ venturers, who are conftantly committing devaftations on mankind by the exercife of a profeffion, of the firft ele¬ ments even of which they know nothing. 3 The PATHOLOGY. The work of Chani-Zadeh,in the opinion ofM.Bianchi, is written in a ftyle which is clear, concife, and elevated : mod of the technical expredions have been borrowed from the Arabic, though fometimes, and efpecially in the anatomical defcription, the author has retained the Greek or Latin word employed in the original fource from whence he derived his information. The following extraCts, which M.Bianchi has tranflated from the text of the author’s firft preface, contain fome interefting details on the arrangement of the book, the nature of its contents, and the motives which induced the fultan Mahmoud to permit its publication by an ex- prefs ediCt. The author of this notice believes that the work of which he has given the outline may be of utility to thofe who have an idea of praCtifing medicine or lur- gery in any part of the Levant. The Angularity of the Oriental expreflion, and the rhodomontade ftyle of the following extradr, will perhaps render its perufal not uninterefting, more particularly as the produdtion is of very recent date ; we are, therefore, induced to give it in its entire ftate, as a curioiity in medical literature. “ Medicine and anatomy are elementary fciences, and the objeCts of general ftudy. They fall within the cog¬ nizance of philofophers, literati, and the minifters of re¬ ligion. Not only learned men and people of found judgment acknowledge that the aim of thefe fciences is the difcovery of truth, but from the remoteft antiquity they have always been confidered, by the higheft autho¬ rities, as conftituting a branch of valuable and honour¬ able knowledge. The advantages which refult from their cultivation are not confined to the human race, but, from the united tellimony of the learned, their beneficent influence embraces all animated nature. The benefits of modern medicine are molt obvious ; and anatomy, found¬ ed on accuracy and attention, has arrived at fuch a de¬ gree of perfection, that every thing which now concerns the treatment of internal maladies, the drefling of wounds and ulcers, and the cure of infirmities, is, by an admira¬ ble difpofition derived from the rules of art, diverted of doubt and exempt from danger. “ In conformity to thefe confiderations, Khamfei Chani-Zadeh has depofed at the foot of the fupreme throne the three following books, bound into one vo¬ lume. “ The excellent Judge, he who is the regulator of the -laws of the ftate, the Plato of the Empire and of the Khalifat, the fovereign to whom fate has revealed fci- ence and wifdom, the Sultan of Sultans, endowed with the wifdom of Solomon, the monarch whole glory recals the time of Cofroes, the King of Kings, inverted with the power of the age of Djemchid, the Sultan, the Son of a Sultan, the intrepid Sultan Mahmoud ; Khan, the fon of the glorious Sultan Abdul-Hamid-Khan, (may the fun of his power never ceafe to illuminate the courfe of his victories and glorious enlerprifes !) his Majefty our Lord, having at length condefcended, during many days, to examine and to make profound obfervations, with jurtice and difcernment, on all the truths of the above-men¬ tioned book, acknowledged that, independently of the great benefit which would be derived from it to the Ot¬ toman empire (the duration of which is eternal), and alfo to Mufl’ulmen, it had never yet been preceded by any work, the advantage of which could be at all com¬ pared with it ; and that, as fuch, it was worthy of being confidered among the precious and innumerable produc¬ tions which have rendered his fortunate reign illuftrious. His majefty, from all thefe confiderations of general good, attached the greateft importance to the circumftance of the printing and publication of the work under his fu¬ preme aufpices. This determination came opportunely to j.uftify the precept, ‘That Kings are infpired.’ “ The figures neceflary for the work having been ar¬ ranged and correfted by the author, who procured an ediit marked with the figns of wifdom and happinefs, from the execution of which the work w'as to be printed 77 at the imperial prefs ; from this inftant, the old and well- attached iervant of the fultan, he who was brought up in purity and lincerity, and under the fhadow of the phoenix proteCtor of his highnefs, one of the guards of the archives, and prefeCt of the imperial prefs, Efiexd Abdul Rahim, after having recited the Bifmillah, (‘ Bif- millah errahman errah'an; In the name of the merciful and compaflionate God,’) immediately commenced the work. But what was purely the refult of the miraculous power of his majefty is, that, without the neceflity of having recourfe to foreign means, by the afliftance of Allah, and by uniting the numerous artifans to be found in Conftantinople, the neceflary figures were engraved on fifty-fix plates of copper. On the other hand, the daily corrections of the author caufed the printing of the work to be foon terminated. At length, thanks to God, who knows all things, in the month of April, 1820, the book was entirely completed and delivered to the binder. It muft be acknowledged that, from the ufeful faCts it contains, the other productions which have rendered the reign of his majefty illuftrious cannot be compared to it. Doubtlefs it has procured for his majefty’s Have, the au¬ thor, under the ftiadow of his majefty’s power, the nume¬ rous rewards with which his highnefs has condefcended to honour him. “ May the Deity, whole power is infinite, be, till the day of the laft judgment, the fupport of our lord and mailer the Emperor of Mufl’ulmen ; and may he, for their benefit, perpetuate our fovereign’s power, and prolong his precious life. Such are the wilhes which I form irt honour of the Prince of Prophets.” Immediately after this unique preface, a table of the contents of the three volumes is given. This table is fol¬ lowed by a fecond preface, confining of little elfe than a repetition of what had already been faid by the author. We are there informed that the production had been be¬ fore prefented to the fultan Mahmoud in the year 1815- 16, under the title of the “Mirror of the ObjeCts in Human Anatomy.” The author concludes by obferving, that, among the caufes which have contributed to the publication of the work, may be enumerated the re¬ proach, made by many perfons, of ignorance in the phy- ficians of the empire with regard to the new doctrines in anatomy and medicine. As to the works of the ancients on medicine, and par¬ ticularly of the Arabians, they are perfectly known to the Turks, fince they are to be found in all the public li¬ braries. Toderini, in his time, reckoned more than a hundred volumes in the library of St. Sophia, indepen¬ dently of the works of Avicenna and Averoes. They have tranflated the works of Hippocrates, Andromachus, Rufus, Galen, Diofcorides, and the moll celebrated matters of Greece. The works of European phyficians are alfo not unknown to them; for, in the library of Raguib, pacha at Conftantinople, there is a tranflation of the works of Sydenham ; and it is well known that, under Muftapha III. the friend and proteClorof Ottoman literature, a tranflation of the Aphorifms of Boerhaave was produced; but, till the prefent time, no work on medicine or furger.y had been printed. The firft volume of Chani-Zadeh’s book contains all that relates to anatomy, and the explanation of the fifty- fix plates, which, as well as all that he has written, appear to have been taken, in part, from the Italian tranflations of the works of Bertin and Palfin. The fecond volume is on the corporeal and intellectual faculties of man, or p/iyjiulogy. The third is on the nature of difeafes and the employment of remedies, conftituting nofology and thera¬ peutics. This is preceded by two prefaces and an intro¬ duction : the firft preface contains only a feries of quota¬ tions from the Koran on the utility of medicine, eulo- giums on the fovereign, and apologies of the author for the errors which may have infimuated themfelves into his production. It is principally with the view of afiifting thofe who are ltudying 78 PATHOLOGY. ftudying medicine, that the author, Chani-Zadeh, re- folved to compofe his work on the rules of fcience, the benefit of which he confiders infinite. He therefore par¬ ticularly recommends the repeated perufal of it, in the order in which the articles occur, as the belt means of avoiding error and forgetfulnefs. As the dofes of medi¬ cines have been determined from the period of infancy to that of manhood, he notices the neceflity, in their adminiftration, of confidering the age, fex, and ftrength, of the patient, as well as the nature of the climate. It is ufelefs, he thinks, to collect a great variety of remedies for the fame difeafe, in order to indulge the caprices of patients; for moll of the complicated preparations are to be found in “ The Provincial” and other treatifes on Materia Medica. At the end of the work there is a lift of various applications, with a reference to all thofe com¬ plaints for which they are necefiary. Independently of medical men, the author folicits the attention of thofe perfons who may perufe his work, to dedicate the fame proportional attention to the feveral articles as he de¬ voted to their competition. As the work is intended equally for thofe out of the medical profeftion, its techni¬ cal abbreviations may be palled over when they are not intelligible ; but, in general, only limple phrafes have been employed in fubjedts relating to general utility. The author difclaims the prefumptuous thought, that the advantages of his book will extend to the whole world; though he, at the fame time, flatters himfelf that it will be ufeful to feme individuals. For admitting, fays he, that a phylician in pofl'eflion of the work had no other merit than that of underftanding it, he would not be ca¬ pable of doing fo much good as an accomplilhed medical man. The latter would always be fuperior to him, from I'.is practical knowledge; but, on the other hand, prac¬ tice alone is inadequate to conftitute a learned profelfional character; whatever may have been his difpofition or op¬ portunities, a profound lludy of books will be equally necefiary. Of thefe afl'ertions, he confiders that the pre- fent work furniflies numerous fatisfadlory proofs. In all inftauces he defires, as the recompenfe of his labour, not only the glory of having ferved his country, but alfo the fatisfaftory convi&ion of his having contributed, by his unremitted efforts, to the benefit of mankind. After the fecond preface cotnes the author’s Introduc¬ tion to Therapeutics, the arrangement of which partakes of that of other works on the fame fubjedl: the third and laft book concludes with a Pharmacopoeia in Arabic and Turkifh, containing 319 formula, applicable to all forts of difeafes. Abridgment of the General Table of Contents. — Book I. Anatomy. Part 1. Ofteology ; Part 2. Myology; Part 3. Splanchnology; Part 4. Angeology and Neurology. Book II. Phyfiology ; comprehending Natural Facul¬ ties, divided into 22 articles. — Corporeal Faculties, in 21 articles.— Of InftinCl, or the Animal Faculty, 1 3 articles. — Of Difeafes in general. — Of the Nature of Difeafes. — The Analogy of Difeafes, divided into 8 articles. — Oil Averfions produced by different Caufes. — On the Signs or Characters of Difeafes. Book III. Nofology and Therapeutics ; comprehend¬ ing 208 foiio pages, and 55 articles, on feparate Difeafes. Vaccination is treated of, as M. Biar.chi fays, in an in- terefting manner, confidering that the author is a Mufl'ul- man. He dwells particularly on the importance of the difeovery, and infills on its advantages over inoculation, which had been long known among the Arabians! He fays, on this occafion, that fmall-pox, though before un¬ known, penetrated into Turkey at the conqueft of Egypt by Selim I. The hiftory of vaccination is given from the work of Dr. Caran (De Caro), a German phy- fician, who, according to M. Bianchi, firft introduced vaccination into the Eall. The author notices alfo the experiments made in vaccination, in the year 1800, at the palace of lord Elgin, at that time the Britilh ambalfador at Conftantinople, as’1 well as thofe inftituted at Vienna, in the prefence of the emperor of Auftria, and the encou¬ ragements afforded by this fovereign, who caufed his own children to be vaccinated. He quotes entire paflfages from the different treatifes on vaccination by Drs. Ranque, Laurens, Maudine, and Guillotin : he more particularly recommends the work of the latter to thofe who are willing to be convinced of the benefits of vacci¬ nation. The fubjedl is terminated with a conclufion, which is entirely original, on the mode of performing vaccination, and what is necefiary in the operation, of which the principal periods and complications are de- feribed. The vaccine lymph is obferved not to be always peculiar to cows, and to be portable. He alfo informs us, that which was firft obtained at Conftantinople came from America, England, and other countries ; but that it is alfo to be procured in the village of Ai'az Aga, in the neighbourhood of Kiadkhaneh, in the environs of Con¬ ftantinople; and that from the laft fource many thoufand perfons have been vaccinated. M. Bianchi informs us, that there have long exifted, at Conftantinople, hofpitals for fick Muflulmen, which are called by the Turks Tab' -y-Khaneh. The greater number of the imperial mofques have fuch eftablifhments annexed to them, but the moll confiderable are thofe of thefultan Bayezid Selim and fultan Suleyman. The following temples have alfo inftitutions of the fame nature; viz. Khafleki Djamy, Tfchinili Djamy, Mihrmahfultane, Djamifi, and Kilidj-Aly-Pacha Djamifi ; as well as the Selimie, at Scutari. There are alfoafylums where patients, reclining on fof3s, are dieted in a careful manner, as in hofpitals properly fo called ; but the afllftance of medicine is entirely negledted. From the word Nev Idjad, or New Creation, M. Bianchi was led to fuppofe that the author, Chani-Zadeh, alluded to eftablifhments founded by the late fultan : but, as Bianchi himfelf had witnefled the di¬ lapidated condition of all the hofpitals, after the death of the above fovereign, and as he quitted the Levant in the year 1815, he thought proper to procure the moft recent information as to theftateof them. He was accordingly favoured with a communication from Dr. Maugin, phyfi- cian of the French hofpital at Pera, in the luburbs of Conftantinople, which is chiefly devoted to the habita¬ tions of Europeans. As it contains many fatisfadtory details of the adlual ftate of the charitable inftitutions of Conftantinople, we fhall infert the greater part of it. “ Sir; I fend you the information which you requefted on the ftate of the hofpitals and druggifts’ ihops of Con¬ ftantinople, at the time of my departure; as well as of every thing which concerns the progrels of medical fci¬ ence among Muflulmen. “ In the reign of the fultan Selim, two fchools were inftituted at the Arfenal, one for the inftrudtion of pupils in mathematics and nautical fcience, another for the teaching of medicine and furgery. The firft of them was under the direction of M. Brun, a French engineer; the fecond under that of M. Gripili, who is of Greek delcenr. Both thefe inftitutions flourilhed as long as the fultan reigned, and while his meritorious favourite, the pacha Hufiein, lived; but the death of this admiral, and the dethronement of the fultan, have involved in oblivion both the noble ellablilhments. “ Barracks were alfo conftrudled at the fame time at Scutari, in the faubourg of Pera; thofe of the arfenal and of Topkhana were reftored, and another was eredted at Levent-Tchiftlik ; fo that each was provided with its hofpital. They were all well furnifhed, but particularly thofe of Scutari and Levanc-Tchittlik ; there being an European phyfician, and a (hop for medicines, at each of them. At prefent no traces of fuch places are to be leen : the barracks and hofpitals have been burnt, from the fpirit of iniubordination on the part of the Janiflaries, at the time of the revolution of Muftapha Barai'ktar, in November 1808. “ The hofpitals of the Arfenal, of Topkhana, and the faubourg of Pera, are now nothing more than chambers of PATHOLOGY. of barracks, where the foldier who Is ill expires of the plague, or any other complaint, unlefs nature is fuc- cefsful in the conteft. There are two or three quackifh practitioners, almoft dying of hunger, to whom the Miri, or public treafury, allows forty or fifty piaftres per month, (25 or 30s.) in order that it may be faid that there are titled phyficians at the places. They go much lefs with the view of treating their patients’ difeafes, than with that of treating themfelves with wine and brandy, which they invariably prefcribe for every diforder. “When the Turkilh fleet is put into commiffion, the diforderis fomewhat lefs; but there is a confiderable in- creafe of expen fe, particularly for the medicine-chefts, which the phyfician caufes to be prepared at fome drug- gift’s (hop in Conftantinople. On this occafion, it is a matter of fpeculation between the two parties, who have a perfeCt underftanding with each other, and charge a great price for an inconfiderable number of medicines. But cultom demands that each veflel ftiould be provided with its medicine-cheft, and much economy could not with propriety be inftituted in fuch inftances. But to what utility can all this tend, either on land, or at fea, when well-qualified medical men are adequately recom- penfed for their attendance on the fick on-board the ad¬ miral’s Ihip alone ? “ At Conftantinople there are at prefent only hofpitals for the reception of tliofe affeCted with the plague, and for patients luffering either under external or internal difeafes which are not of a contagious nature. The French government has two; one at Galata, for complaints of an ordinary kind 5 the other in the faubourg of Pera, for fuch of their unfortunate countrymen as are attacked by peftilential difeafes. The Greeks have three great hofpi¬ tals, of which two are devoted to the plague. The Latins have, in the faubourg of Pera, but a Angle hofpital, which is defined equally for the relief of tliofe fluttering with the plague and with other difeafes. Thefe are all the hofpi¬ tals which now exift at Conftantinople : it rauft be ac¬ knowledged that, while fuch eftablifliments do honour to humanity, the individuals entrufted with the direction of tnofe for the plague are accuftomed to engage in fpecu- lations, no lefs barbarous than infolent, on what each patient is likely to leave them : for it is a well-known faCl, that they regard themfelves as the univerfal legatees of all the unfortunate objeCts that are brought there, and that the death of the patients is the more certain if they are fo unlucky as to poflefs any money or jewels. In addition to fuch villainy, they have the audacity to fend for fale, at the bazars of Galata and Conftantinople, the fpoils of their ill-fated victims. “No druggift’s ftiop in Conftantinople is directed by a Turk : molt of them belong to Greeks, a few to Arme¬ nians, and fome to Europeans. As this profelflon re¬ quires previous ftudy, the Turks, who have no acade¬ mies nor faculties of medicine, and who never travel to gain information, feel their incompetency to undertake the fuperintendance of fuch eftablilhments. “It was in the month of June 1820, that I quitted Conftantinople; and fince faw with much pleafure, and a lively intereft, the work which you (bowed me. The great progrefs juft made by the Turks, in the publication of this production, by order of the fultan Mahmoud himfelf, at once proves that the fovereign prefers difcoun- tenancing the prevailing prejudices, and that he is in poflefilon of fufficient power to filence fanaticifm, which would not have failed to advance loud remonftrances againft the impiety of reprefenting human figures : but fuch complaints might have been anfwered by the alfur- ance that the plates were not executed with trifling or futile views. “If reafon ftiould ever gain the afcendancy among thefe people, the fultan will eftablilh hofpitals, and cauie laza¬ rettos to be conftruCted at Proti, an ifland oppofite the capital, in order to arreft, at the port of Conftantinople, the fcourge which annually decimates the Ottoman em- Vol. XIX. No. 1288. 79 pire. I have the honour to be, &c. Maugin. — Paris, April 1821.” GENERAL PATHOLOGY. In the prefent philofophic age, it appears needlefs to difcufs the propriety and neceftity of being guided by reafon in our pathological inveftigations. Very few pro- feffiona) gentlemen will now be found ftriCtly empirical ; and thofe few are among the lead honoured and lead de- ferving in our profeflion. There is fomething in the human mind fo prone to enquire into the caufe why, and the reafon wherefore, that the verieft empiric in the prac¬ tice of phyfic will never be contented with attaching himfelf to faCts, as he profefles, without regard to infe¬ rential reafoning. There is- fomething fo gratifying to one’s love of fcience, fomething which fo evidently leads to better information, even in the vagueft explanation of natural phenomena, that we cannot be furprifed that it has been attempted in all ages. Yet, in the courfe of our hiftory of medicine, we have had frequent occafion to (how how fatal has been the refult of too much theory. Independently, however, of the circumftance that what is injurious to the progrefs of fcience in its infant (late, may ceafe to become fo when it is more advanced, we have found hitherto no fyftem of medicine which has fufficiently accounted for all morbid phenomena, or in which many huge gaps and deficiencies have not been filled up by gratuitous afler- tions. In the infant ftate of medicine there can be no doubt that theory often exerted a moft decided influence on that fcience. But the paucity of faCts, the data whence the theories of the ancients were framed, were the caufe of their frequent errors. They were like labourers at¬ tempting to build a lofty palace with a few (tones. In our own time, however, we have fo far advanced in the ac¬ cumulation of faCts, that, though much remains to be done, we are compelled in fome meafure to generalize and l'yftematize our knowledge, which elfe would become too burthenfome for memory. To follow up our fimile, we may be faid in our own time to be in pofleflion of materials fufficient for building a liable edifice ; and hence we may now look forward to the eftabliftiment of a fyftem which, to ufe the arrogant exprefiions of Darwin “ may not moulder, like the (truCtures already ereCted, into the fand of which they were compofed, but which may (land unimpaired like the Newtonian Philofophy, a rock amid the wafte of ages.” We (hall not paufe here to enquire into the utility of fyftems of medicine. Our periodical medical publications have lately railed much uproar againft fyftems. It muft be obvious to every one, how'ever, thataferies of dry in- fulated faCts, or of reafonings applicable only to a limited number of phenomena, can never be fufficiently remem¬ bered, or indeed perfectly known. Provided, therefore, we wander not into the mazes of hypothefis, provided our analogies are not forced, or our claflifications likely to lead to erroneous methods of practice, it muft be al¬ lowed that we are advancing our knowledge, clearing away many erroneous notions, and reconciling many contradictory opinions, by taking general and extended views of difeafe. See vol. xvii. p. 245. We have faid that the knowledge of the ftruCture and functions of man ftiould precede the ltudy of pathology. Of the animal ftruCture we have given an ample account in the firft volume of our work, under the article Ana¬ tomy ; of the fecond we propofe to treat under the ar¬ ticle Physiology. In the mean time, the more clearly to develope the opinions we have adopted, it will be ne- ceflary to give a ftiort (ketch of the economy of man, and of the moft prominent fyftems and moft important Itruc- tures which belong to his organization, the better to un- derftand in what difeafe a deviation from this ftate con- fifts. In the organization of man, then, the firft fyftem to be Y confidered 80 PATHOLOGY. confidered is the nervous. It confifts of the cranial brain, the fpinal marrow, nerves, and ganglia. By means of this fyftem, all mental emotions are communicated to the other parts of the animal frame, and, through its medium, all external impreflions are communicated to the mind. We obferve likewife a fibrous ftruCture of different kinds in various parts; as mufcular, offeous, &c. the moil ge¬ neral and important of which are the mufcular ones. To thefe is added a fundamental cellular ftruCture, which ap¬ pears to conneCt all parts of the other fyftems together; and which has various appearances in regard to diverfity of fubftance, and indeed in regard to the fecretions derived from it. The union of thefe three fyftems takes place in various modes : in fome cafes in tubes, or on membranes, See. Sec. and the more remarkable of thefe unifons may be aptly divided into the digeftive, refpiratory, fanguife- rous, fecernent, and abforbent, fyltems; and this phyliolo- gical division we have taken as the bafis of our arrange¬ ment, which agrees with the excellent one lately made by Dr. Good, in his Phyfiological Syltem of Nofology. Many objections have been made however to all the prefent arrangements ; the mod important of which is, that, by allowing the attention of the medical practitioner to be exclulively directed to one fyftem or to one organ, it prevents that due attention being paid to morbid cate¬ nations, which the practice of phytic imperioufly de¬ mands. There is nothing, however, in the nature of - nofology which renders this error a venial one. It mull be allowed that morbid impreflions are generally' primarily made on one particular tilTue or organ; and it mull be allowed too, that a fyftem which is fecondarily affeCted, often fuffers the moft feverely ; or that the fyftem fecon¬ darily affeCted may- be the moft important to life, and hence our attention fhould be chiefly direCted towards it. We will however venture to affert, that whoever has affidu- oufly ftudied the ftruCture of parts and their phyfiology, cannot fall into the error of confining his attention to one part of the animal economy to the exclufion of the reft. To render this more plain, we (hall proceed with fome further account of the aCtion of the different fyftems above mentioned upon each other. If the animal frame were fo conftruCted that no inteftinal motion was necef- fary for the continuance of its external aCtions, we could readily fuppofe it poflible that the nerves would be unaf- feCted by any change in the mufcular fyftem, and the latter might produce its functions without any impreilion from the former. But, when we fee, that the cerebral functions can only be continued while blood, pofleffing certain properties and component parts, circulates accor¬ ding to given- laws through its fubftance; and when we coniider that the mufcular fyftem can be called into ac¬ tion only by the nervous fyftem, either direCtly by means of nerves, or indirectly by fluids, deriving fome of their properties from the nerves; then we cannot fail to have the moft certain conviction of the aCtion of the one on the other. It is extremely difficult to know at what part to begin fil'd, when fpeaking of aCtions which are thus always de¬ pendent one on the other, and which are always in a circle. We take, however, the heart ; and, fuppofing it of a fibrous fundamental ftruCture, and fupplied with blood and nerves, we proceed to confider its aCtion. A cavity of the heart called the left ventricle, having received a certain fupply of blood, propels it by contraction into the aorta, and from it into the fmaller arterial branches. Thefe branches further aflift the motion of the blood by contracting their circumference, the power of contrac¬ tion being in an inverfe ratio to the diameter of the tubes. The terminations of arteries are further affifted in pro¬ pelling the blood by' the property of capillary attraction ; reins reftore the fluid to the heart in a direCt ftream, al¬ tered however in its properties; for veflels called Jeccr- nents have, by means of an affinity exifting between* their coats and certain parts of blood, removed fome parts of that fluid ; and other veflels, called abforbents, have re- ftored a portion of other component parts previoufly fe- creted from the blood, or received from without. The moft obvious change undergone during this circulation is a-change in the colour of the blood ; this however is reftored by fecond circulation produced by the other ca¬ vities of the heart, and is called the pulmonary procefs. In this circulation the blood appears to be indireCtly ap¬ plied to atmofpheric air, and hence to acquire a principle which reftores its colour. But this procefs is under the immediate influence of the nervous fyftem, and is difeon- tinued when the aCtion of that fyftem is fufpended. After this procefs has taken place, the blood is reftored in its priftine ftate to the heart. The changes which fe- cretion and abforption effeCt in the blood are of courfe depravation of its elements on the one hand, and repro¬ duction on the other. Secretion has been defined “ a pro¬ cefs which feparates from the blood fubftances which are not found in that fluid.” This propofition, as it Hands, is fo abfurd, that we ihall take no pains to confute it. Secretion is better explained by fuppofing that it deprives the blood of certain of its elements, and combines them in a manner different from that in which they previoufly exifted in that fluid; and further, that our chemical ana- lyfis is not fufficiently accurate to deteCt the elements (ftriCtly fpeaking) of this re-compofition. The number of the various fecretions is too great to be here detailed. Some of them are re-abforbed, and fome pafs from the body by various outlets. Previous to thefe circumftances, however, their progrefs is retarded, and their nature changed, by fubftances called glands. The abforbents receive thefe fecretions from the whole funda¬ mental or cellular ftruCture ; they receive the fluid previ¬ oufly fecreted from the blood; they further receive from certain expanfions of the fundamental or cellular ftruC¬ ture extraneous bodies. Thefe are, the (kin, the lining of the pulmonary air-cavities, and the alimentary canal. The abiorption from the (kin is in general probably final! ; though, when internal abforption is deficient, cutaneous abforption is no doubt increafed. Of the pulmonary cavi¬ ties the foreign matter abforbed is derived from the air. The nature of this abforbed matter is not precifely known : It is indifpenfably neceffary, however, to the performance of life. But, the greateft portion of extraneous matter is abforbed from the alimentary canal. The whole of this canal is perhaps an abforbing as well as fecreting furface ; a peculiar portion of it is however much more aClive than the reft ; and this portion is placed fo far down, that the fo¬ reign bodies received have had time to fuffer the changes induced by the fecretions poured into the canal, and thereby to have its nutritive part feparated from that ex- crementitious mafs. The great extent of this expanfion, its numerous fecretions, the clofe relation it holds with the nervous, its intimate relation with the vafcular, fyf¬ tem, and by their means indireCtly with every part of the body, render it perhaps the moft frequent medium of general difturbance in the human frame; and hence it may with great propriety be confidered in the firft part of our pathological difq uifitions. The view' we have taken of the human frame clearly indicates the iinpoffibility of ever forming a nofology in the old and reltriCted ufe of the term ; that is, an arrange¬ ment of difeafes founded on the affumptioh that an indi¬ vidual part or a feparate, ftruCture can be difordered without involving the reciprocal aCtion of various other parts. When the phyfician, therefore, finds fever ar¬ ranged under the clafs Hasinatica, he is not to fuppofe that we are difinclined to admit the important part which the nervous fyftem has in this difeafefand foon of many other orders, genera, and fpecies. In this place we mult recur to our article Nosology, in order to offer fome apology to our readers for neglect¬ ing to redeem our promile of tiling Cullen’s fyftem. We trult this promife will be deemed better “honoured in the breach than in the obfervance,” when it is confidered, that many errors had been complained of in Cullen’s 3 arrangement. 81 PATHOLOGY. arrangement, even from its firft publication ; and that, fince that period, phyfiology and pathology have made fo much progrefs, that they may literally be faid to be revolutionized. Nor is the fyftem we have adopted to be confidered as a crude fpeculation, un matured by experi¬ ence, or unfanftioned by general affent. .It is founded on the cleared and mod comprehensive views of the ani¬ mal economy; and its projector was entirely free from that fatal error of mod new fydem- makers, that of defpi- fing the labours of his predeceffors in the fame path. On the contrary, he has availed himfelf of all that had been done before him by Sauvages, Pinel, Linnaeus, Cul¬ len, Vogel, and many others; and has added the infor¬ mation which long dudy and experience had furnilhed him with. A dronger reafon than all thefe, which has induced us to employ Dr. Good’s nofology, is its claffical and correct nomenclature. Our medical technicology abounds in the mod barbarous and abfurd appellations; which, fo far from having any meaning, or affording any account of the nature or appearance of difeafe, often ferves only to perpetuate fome ancient and ridiculous notion. Often derived from the oriental languages, half latinifed, they have been long cenfured by claffical phy- ffcians ; and fome alterations have accordingly been made from time to time. But it was referved for Dr. Good entirely to alter the medical nomenclature, and at once to fimplify and adorn a very dry and uninviting fub- je£t. We may further remark, that Dr. Good’s work is patronifed by the heads of the medical profeflion in Eng- We (hall now' give an outline of the different fydem s, or claffifications, of difeafes, which have fucceffively pre¬ vailed ; and the few remarks we fliall make as we go on, will, we think, furniffi additional reafon s for the courfe we mean to adopt, of forming the great body of our ar¬ ticle upon the fyftem of Dr. Good. Dr. Good himfelf very judicioufly obferves, that no art or Science can be acquired, for none can be clearly treated of or communicated, without arrangement. All nofo- logical works, therefore, poflefling any value, have an ar¬ rangement, or method as itis called, of fome kind or other. The Simplest arrangement, if it be in any -way worthy of the name, is the alphabetic, of which, in the prefent day, we have many copious examples, highly valuable as works of eafy reference, though fcarcely entitled to rank under the character of fydematic arrangement. To this daffification belongs the very excellent and important work of Dr. Heberden. — Another modification which has been had re courfe to, is that of the duration of dij- enfes, .as divided into acute and chronic ; it is a modifica¬ tion of confiderable antiquity, and has defcended to us in the works of Aretasus, and of Cadi us Aurelianus.- — A third modification has confifted in taking the anatomy of the animal frame as a ground-work for divifions ; and confequently in afiforting difeafes, as has been done by Jonfton, Sennertus, and Morgagni, (and fince recom¬ mended by Dr. Mead in his Medical Precepts and Cau¬ tions,) info thofe of the head, cheft, belly, limbs, and aim oft every other part. — A fourth invention has fixed upon the fuppofed cauj'es of difeafes as a bafis of diftribu- tion ; and to this has been applied the epithet etiological , from the Greek term aina., a caufe; it has acquired more popularity than any of the preceding, and was es¬ pecially embraced by the fch ools of Boerhaave, Riverius, and Hoffman. — Sometimes a mixed modification has been attempted, as in the nofology of Dr. Macbride, who takes extent for his firft two general divifions of difeafes, as being univerfal or local -,J'ex for his third ; and the age of infancy for his fourth and laft. — And fometimes, and far more generally of late years, the nofological fyftem has been built upon the diftinblive J'ymploms of difeafes; the peculiar marks by which they identify themfelves, and, fo to fpeak, become individualized: and fuch is the princi¬ ple adopted by Sauvages, Linnaeus, Cullen, and all the Hi oft celebrated nofologifts of recent times. This laft is, in effeft, the only method in any degree worthy of attention ; for it is the only one that will ge¬ nerally hold true to itfelf, or on which we can place any dependance. Of the feat of difeafes we often know but very little $ of their caufes far oftener (till lefs ; but there are certain marks or characters in the ufual progrefs of moll difeafes which uniformly accompany and diftinguilh them, and to which, therefore, the epithet pathognomic has been correftly applied. It is not, indeed, to be con¬ tended that thefe distinctive Signs are as constant and de¬ terminate as many of the distinctive figns that occur in zoology or botany. So complicated is the animal machi¬ nery, fo perpetually alterable and altered by habit, cli¬ mate, idiofyncrafy, and the many accidental circum- ftances by which life is diverfified, that the general rule mull admit of a variety of exceptions ; and is here, per¬ haps, rather than any-where elfe, bell established by fuch exceptions. Yet, after all, every diftinCt difeafe, occur where it may, and under what peculiarity of constitu¬ tion it may, proves fo generally true to its own courfe, and is fo generally attended by its own train of fymp- toms, or “ co-incidents,” (which is the literal rendering of fymptoms,) that he who fteadily attends to thefe will not often be greatly deceived; “ and if he ftiould be, (fays Dr. Good,) he can find no other guide to fet him right.” Plater may be regarded as the morning-ftar that firft: glimmered in the hemifphere of fymptomatology, as Ser- vetus was in that of the circulation of the blood. The light of both was feeble and tremulous ; but it twinkled in the midft of darknefs, and led on to the brightnefs of day. His work, entitled Praxis Medica, in which he gives an imperfect Sketch of a fymptomatic plan of nofo¬ logy, was published in 1602. Sydenham, if he did not avail himfelf of it, was actuated by the fame quickening fpirit; for his various treatifes and epiftles, published for the moll part mifcellaneoufly, are a practical comment upon Plater’s principle, and feem chiefly to have Stirred up the well-ftored and comprehenfive mind of Sauvages, who was peculiarly attached to Sydenham’s opinions and practice, whom he is continually praifing, and whom he distinguishes by the name of “ Anglus Hippocrates,” to that full illuftration of the fymptomatic method which has given form and being to almoft every attempt that has fince appeared upon the fubjedl. Sauvages firft published the outlines of his plan in 1731, in a duodecimo volume, under the title of “ Nouvelles Clafles de Maladies,” after having fubmitted his intention to the judgment of Boerhaave. This precurfory Sketch defcended no lower than to the divifion of genera ; but, having been encouraged to perfevere, he laboured on the fpecies, and introduced them in their proper fuccef- fion into a new and more extenfive edition of his work, published in 1763, in five volumes oCtavo; and, conti¬ nuing his exertions yet further in the fame vineyard, he put his finishing hand to the great talk he had under¬ taken by preparing a Still more complete and final edi¬ tion, which he did not live to publish, but which was given to the world Shortly after his death, in 1768, in two large volumes quarto. The “ Nofologia Methodica,” for fuch is the title of M. de Sauvages’s work, is, indeed, an Herculean la¬ bour. It confifts, in its lateft and mod perfect form, of three diftinCt arrangements, a fymptomatical, an etiological, and an anatomical, fo as to accommodate itfelf to the tafte of the old fchool as well as of the new. The fymptomatical, to which the others are profefledly fubordinate, is by far the mod extenfively elucidated; and comprifes ten clalfes, (each introduced by an elaborate pathological fynopfis,) upwards of forty orders, more than three hundred genera, and an almoft innumerable holt of fpecies. “ Quel no mb re prodigieux d’ennemis !” exclaims M. de Ratte, alluding to this valt. mu Iter, in his eulogy on the author, delivered before the Royal Society of Sciences in Montpellier; or rather allu¬ ding 82 PATHOLOGY. ding to the fomewhat fmaller mufter of the preceding edition, for the laft was not then publifhed. We have yet, however, to add the varieties, which under feveral fpecies are not few ; and to bear in mind, that to every variety, fpecies, and genus, as far as their relative cha¬ racters will allow, is allotted a definition, lift of fyno- nyms, liiftory, diagnofis, prognofis, and mode of cure; with, frequently, an exemplification of cafes, and a brief ftatement; of the peculiar opinions of other writers, be¬ fore we can fairly appreciate the entire mafs of matter with which the volumes of M. de Sauvages abound. He feems, indeed, to have been defirous of collecting mate¬ rials of every kind and quality from every quarter to which a market was open; and of following up every deviation from health into all its poflible as well as its aCtual fliades and ramifications, fo that no man mighj have to add a lyllable to his work after him. It is not very furprifing, therefore, that a work thus conftituted and conducted fhould be confiderably too dilfufe. This is its leadingerror; yet it is not a.venial one, and was by no means deftitute of advantage at the time of its commif- fion ; for the very amplitude the work evinces rendered it, when firlt completed, a fort of nofological bazar, to which every one might have recourfe who was in purfuit of this new branch of ftudy; and where he might ac¬ commodate himfelf with whatever articles he ftood in need of. To the time of Cullen the general outline or claftific arrangement of Sauvages was left without much difturb- ance; for, although the order of fucceflion was changed, and changed differently in every new attempt, the names, in a few inftances diverfified, and occafionally fome addi¬ tion made to the number, ftill the ten Sauvagefian claffes were fubftantially retained and adhered to. Thefe claffes are as follow : VI. Debilitates, Debilities. VII. Dolores, Local Pains. VIII. Vefania, DefeCts of Judgment. IX. Fluxus, Fluxes. X. Cachexia, General De¬ bility. I. Vitia, Cutaneous Difeafes. II. Febres, Fevers. III. Phlegmufice, Inflamma¬ tory Fevers. IV. SpaJ'mi, Convulfive Dif¬ eafes. V. Anhelationes, Difficult Ref- piration. The ten claffes comprife forty-four orders, three hun¬ dred and fifteen genera, and about two thoufand five hun¬ dred fpecies; being rather more than an average of eight to each genus. In Linnaus, while the above claffes remain fubftantially the fame, their order of fucceflion is varied, the names confiderably altered, apparently from a preference of Latin to Greek terms, (as in the ufe of MeAtales for Vefaniae, Motorii for Spafmi, and Deformes for Ca¬ chexias;) and the lift of claffes is increafed to eleven, by advancing the Exanthematicas of Sauvages, which in him occurs as an order of Phlegmasia, to the rank of a diftinfl: clafs ; while the clafs Vitia, with which Sau¬ vages opens, is by Linnaeus thruft to the end of the feries; which at length will appear as follows : Exanthcmatici, Eruptions, j Motorii, Involuntary Mo- Critiei, Common Fevers. Phlogiftici, Inflammatory Fevers. Dolores, Painful Difeafes. Mentales, Lofs of Judgment. Quietules, Lofs of Motion. tions. Supprefforii, Obftru&ions. Evacuatorii, Evacuations. Deformes, Changes in the Solids. Vitia, Changes in the Sur¬ face. Some degree of abbreviation is unqueftionably hereby produced, which is always defirable when accompanied with perfpicuity. But there are few cafes in which the author has not preferred the definitions of Sauvages, though frequently too diffufe; for the perpetual aim at brevity in Linnaeus leaves him too general where he has not occafion to refer to other difeafes, and too perplexed and intricate where he has. The great objefl of Vogel was to fupply what he con¬ ceived to be omiffions on the part of Sauvages : and hence he gives a mufter of not lefs than 560 genera, being nearly double the number of his great prototype. But, to accomplifh this, he has been compelled to elevate to the rank of genera a great multitude of affections which ought only’ to be contemplated as fpecies, many of which are merely fymptomatic of other difeafes, and not a few, as Rifus* Fletus, Sufpirium, Clamor, (fome of them, indeed, derived from Linnaeus,) which have no claim to be regarded as difeafes at all. In hisclaflific arrangement, while he takes Sauvages for his guide, he changes the line of fucceflion as confiderably as, though in a'different manner from-, Linnaeus. He degrades the Exanthema- tici of the latter from aclaflific poll, and introduces them, as well as the Phlegmafiae of Sauvages, as mere orders under his clafs Feeres. He unites into one clafs the Anhelationes and Debilitates of Sauvages under the name of Adynamia; and, having thus reduced the number of the Sauvagefian claffes to nine, he raifes them to eleven by the creation of two new claffes, which he calls HYPERCASTHESES,and Deformitates; the former, properly enough, feparating Sauvages’s “ moralities of the llomach” from genuine “ mental d Borders, ” and the latter including external deformities of a prominent cha- ra6ter. We ftiall enumerate his claffes according to his own arrangement in the year 1764, as follows: Febres, Fevers. Cachexia, General Debility. Profiunia, Evacuations. Paranoia, Aberrations of EpiJ'chefes, Suppreflions. Mind. Dolores, Pains. Vitia, Superficial Deformi- 1 Spafmi, Spafms.- ties. Adynamia, Debilities. Deformitates , Solid Defor- HyperaJlheJ'es, Depraved Sen- mities. fations. His definitions are peculiarly concife, but convey too frequently nothing more than general and indiftimfl ideas : while his new-created terms are peculiarly long and cacophonous, as in the words Hypofpadiaeos, Diony- fifeus, and Hyperartertifcus. For his fpecies and varie¬ ties, or rather thofe he has not elevated to a higher rank, he feems, like Linnaeus, to have depended, for the moft part, upon Sauvages. The fyftem of Sugar makes lefs deviation from that of Sauvages than either of the preceding; and may be regarded rather as an enlargement than a re-modification of it. In various refpefls, indeed, it alters the feries of fucceflion, but it retains the name of every clafs ; though it increafes the number from ten to thirteen, by advan¬ cing the Sauvagefian orders of Plagje and Exanthe- matica to the rank of claffes, and by introducing a new clafs denominated Suppressiones, defigned to correfpond with a confiderable part, though not the whole, of the Supprefforii of Linnaeus, as Linnaeus in¬ tended this laft to correfpond with a confiderable part, though not the whole, of the Anhelationes of Sauvages. Sagar’s Nolology was publifhed in 1 776. His claffes are — The Sauvagefian genera are not much interfered with in refpefl to number. Upon the whole they are rather ex¬ tended, and amount to 326. The generic names, how¬ ever, are occafionally altered, and the definitions, which are formed by an almoft conftant reference from one ge¬ nus to another, are neceffarily drawn up in very differ¬ ent terms, in order to quadrate with fuch a change. Vitia, Cutaneous Difeafes. Flags, Wounds. Cachexia, General Difeafe. Dolores, Pains. Fluxus, Fluxes. Supprejfiones, Suppreflions. SpaJ'mi, Spafms. Anhelationes, Defecti ve Ref- piration. Debilitates, Debilities. Exanthemata, Eruptions. Phlegmajia, Inflammations. Febres, Fevers. Vejania, Madnefs. PATH Sagar’s definitions are moflly taken with little variation from Sauvages; but are rendered intolerably long by- confounding Sauvages’s generic characters with his ge¬ neric descriptions, and running the two together: fo that, in (lead of eighteen or twenty- words, which is, perhaps, the utmoft that ought to be allowed, and more than the Linnaean canons permit in botany, we have Sometimes up¬ wards of a hundred, filling an entire page, as in rubeola, whofe definition, if fo it may be called, extends to a hundred and ten lines ; and in aphtha, which employs a hundred and thirteen. He is lefs redundant in the num¬ ber of his genera than Vogel, though he makes a boall of having extended them to 351. It would have been better for him, as Cullen obferves, to have boafted of hav¬ ing exercifed, in an equal degree, his power of compref- fion. The fyftem of Sagar is rendered more complete than either Vogel’s or Linnaeus’s by being filled up with his Species. Thefe, however, are deduced, with occa- fional alterations, from Sauvages, and exhibit the Same verbofity as his genera. The main objeCt which- Cullen propofed to hiinfelf, and a more important he could not laydown, was that of brevity and Simplicity ; and the Sauvagefian claffification (for Sagar’s was not then before the public) offended in both refpeCls. He determined, therefore, upon changing it, and re-calling the fyftem from its commencement. Inftead of ten claffes, he conceived that four might Suf¬ fice, formed, as he propofed to form them, of a caliber capacious enough to Swallow up all the reft. He moulded his four claffes accordingly, and diftinguiftied them by the names of Pyrexia, Febrile Disorders. Cachexia, General Diforder. Neurofes, Disorders of the Locales, Local Difeafes. Nerves. Influenced throughout the whole of his reform by the Same Spirit of fimplicity and concentration, he reduced the forty-four orders of Sauvages to twenty, and his three hundred and fifteen genera to one hundred and fifty-one. He next carried his pruning hook into the field of Spe¬ cies ; Some he found to be repetitions of the Same difeafe occurring under different genera, and others mere Symp¬ toms of other disorders, inftead of diftin<5t or idiopathic affections ; all which were fteadily lopped off; and, in this manner, the reduction in the Species bore an equal proportion to that in the genera. The genera and Spe¬ cies that remained were next enlifted into his own Ser¬ vice, moftly with the refpeCtive names affigned them by Sauvages, though the definitions were generally re-com- pofed, and apparently modelled in confonance with the reformer’s own practical observations. Thus completed and fit for ufe, the new fyftem was firft darted in the larged medical School of Europe, its author prefiding at the head of it. It is not, therefore, furprifing, that it fliould inftantly have ruftied into popu¬ larity, and become a fubjeCt of general approbation. Yet it did not (land in need of this adventitious Support to introduce it to public favour. Its aim at fimplicity, as wdl in extent as in arrangement, was noble, and befpoke correCt views and a comprehenfive mind ; it promifed a definable facility to the (Indent, and a chafte finifti to the architecture of the nofological temple. The author ftiowed evidently that he had laboured his attempt in no ordinary degree ; and many of his definitions discovered a maftery that had never before been exemplified : pic¬ tures painted to the life, and of proper dimenfions. To this extent of praife Dr. Cullen is fairly entitled. That his fyftem, nevertheless, has faults, and insurmount¬ able ones, it would be abfurd to deny; for they meet us at the very outfet, and run through the whole of its tex¬ ture and conftitution. Dr. Good notices the errors and inconveniences of the fyftem under the three following heads: 1. DefeClive arrangement. 2. Want of discrimi¬ nation between genera and Species. 3. LooSeneSs of dis¬ tinctive character in the laft general divifion, or clafs. Vol. XIX No. 1289. O L O G Y. 83 We (hall have occafion to notice only the firft and laffof thefe heads. Of the four claffes adopted by Dr. Cullen, the firft two, PYREXi-ffi and Neuroses, have considerable merit, and this merit is exclusively his own. Each term fuggefts to the mind at once a peculiar group of difeafes, of Sufficient range for a leading divifion, and occupies a province pof- feffing a Sort of natural outline, or urrondiffement , as the French chorographers denominate it; in” which, if the boundary occasionally fail or lofe itfelf in the adjoining provinces, it is eafily Supplied by the hand of art. At times, indeed, it Seems difficult, under Such a fyftem, not to overftep the natural boundary imported by thefe terms in their common life, and, like the late ruler of France, to give in many parts a broader and an altogether arti- iicial outline by the invafion of adjoining diftriCls ; and, from the paucity of his claffes, Dr. Cullen has frequently found himfelf compelled to Such a tranfgreffion, and has afforded us a palpable inftanceof it in the very clafs with which he commences ; for the tribe of Hemorrhages, which forms one of its orders, have no direCt catenation with any idea fuggefted by pyrexy in the common ufe of the term ; they require coercion to bring them into a date of union; and, what is (till worfe, Dr. Cullen, with all the force he could employ, has found himfelf incapa¬ ble of coercing more than one half of them ; and, conse¬ quently, has been obliged to leave the other half behind, or rather to banifti them for contumacy to the extreme region of his fourth clafs. So that in his fyftem they ex¬ hibit a wide and lamentable divorce, and afford a ftriking and perpetual memorial of the tyranny which pervades it in Spite of its attractive exterior. Still, however, the firft two claffes are fubftantially good; and have in Some fliape or other been copied by almoff every Succeeding nofologift. The third clafs has all'o a claim to attention, though the term Cachexije, by which it is denominated, has been ufed, and (till con¬ tinues to beufed, in Senfes fo extremely different by dif¬ ferent writers, that it by no means fuggefts to the mind a conneffed group of difeafes, with the Same readinefs as Pyrexiae or Neurofes. As a clafs, indeed, the divifion of Cachexias occurs in all the preceding writers, with the exception of Linnaeus; and fo far Dr. Cullen can plead -authority'; in Linnseus it is reduced to a genus; and in Vogel it is given, with lingular itnprecifion, both as a clals and a genus, diftinguiftied by a mere difference of number. Under every w'riter, however, the term is em¬ ployed in a various fenfe ; Sometimes importing depraved external colour alone; Sometimes depraved colour and form ; Sometimes depraved colour, form, and fize ; and Sometimes, as in Cullen’s definition, deprived habit of the whole or a great part of the body, withoutany notice whatever of the preceding qualities. But by far the moll faulty and incorrigible part of Dr. Cullen’s arrangement confifts in his laft divifion, or clafs, Locales. It has no Scientific relation to the preceding claffes, no parallel or appofition with them. To have brought it into any Such kind of bearing, the w hole of the former ffiouki have been denominated conjunctively Universales, as has been done by Dr. Macbride. But this would have deftroyed the general calling of the ar¬ rangement, and have produced a divifion which was not wanted, and perhaps does not exill. It mult be obvious to the flighted obferver, that the Sole objeCt of this clafs is to form an appendix to the three preceding, for the pur- pofe of receiving, like the Cryptogamia ot the botanical fyftem, Such genera as the foregoing claffes could not be brought to include. From its name and capacity, how¬ ever, it is altogether inadequate to its intention ; and, while the term (lands inlulated and without relation to its fellow-terms, its intrinfic and effential idea (that of articular “part or place”) creates an insurmountable ar to the reception of a great proportion of the genera which it is direClly intended to comprife. Of thefe difeafes, therefore, Cullen has been obliged Z to 84 PATHOLOGY. to give a lift at the end of his Synopfis, under the title of “ Catalogus Morborum a nobis omifforum, quos omiffiffe fortafiis non oportebat 5” and has thought himfelf called upon to offer an apology in his Prolegomena. “ Thefe ©millions,” fays he, “I confefs and regret; but various reafons operated to the omiffion of fome difeafes. 1. In the firft place it mnft be acknowledged that feveral utterly efcaped our attention. 2. Next, there are others, Suffi¬ ciently known, for which a fit place cannot he found in our fyftem. 3. And, laftly, there are others whofe hiftory -among medical w'riters is fo imperfedf, that no fit place or character can bealfigned to them.” It is the fecond of thefe apologies, which we have printed in Italics, that has determined us in the courfe we have adopted, of rejedling the fyftem altogether. Time and ftridter attention may overcome the evils t8 which both the others relate. But the utter want of fit places for well-known difeafes in a nofological fyftem, and this too, in the opinion of the author of the fyftem, is a defedf from which no time or labour can ever relieve it. , Since, therefore, the diftinguiflied reputation of Dr. Cullen was incapable of fecuring to his nofological fyftem the popularity with which it was at firft greeted ; we need not wonder if a hoft of learned rivals, few of whom how¬ ever have humiliated him by their competitions, fnould, in different parts of Europe, have endeavoured to offer fchemes big with the fair promife of realifing the noble objedf he had in view, and free from the defeats he has exhibited. Thefe rival attempts may be fummed up in a few words : for fuch is the difficulty of the fubjedl, that none of them have been eminently fuccefsful ; while the greater part have dropped from the cradle into the grave. The chief foreign competitors are Selle, Plouquet, and pinel. — Selle is rather a monogrammift, to borrow a term from the vocabulary of natural hiftory, than a writer on general nofology. His firft attempt was confined to the province of fevers alone, and appeared at Halle in 1770, under the title of “Methodi Febrium naturalis RudL- menta:” and it was only to an enlarged edition of this, publifhed at Berlin in 1786, that he fubjoined a fpecimen of his general claffes. They are altogether theoretical; and, as he has not accompanied them with their refpedtive genera, it would be fuperfluous to copy the claffification. The cloudinefs that hangs over his divifion of fevers leaves us. without regret that he did not complete his entire fciieme. It may be fufficient, perhaps, to obferve, that in his “ Methodical Pyretology,” rheumatifm, ca¬ tarrh, and exanthems, are included under a fingle genus. The “ Outlines” of Plouquet furnifh a fyftem that wan¬ ders lefs into theory ; but which is far too complicated, and certainly not without its nebulofity. It was pub- lifned at Tubingen in 1791, in four volumes odlavo, under the following title : “ Delineatio Syftematis Nofoio- cise naturte accommodati.” It is fingularly diftinguiflied by the author’s fondnefs for long crabbed words. He made a far better prefent to the public a few years after¬ wards in his “ Initia Bibliotheca il ledico- praftica, et Chi’ rurgia realis ; or Hints towards a Medicaland Chirurgical Library,” extending to feven volumes quarto, in the order of an alphabetical arrangement. To Pinel, as to Selle, we are indebted for both a mo¬ nographic and a general attempt. The firft is his well- known “Traite Medico-Philofophique fur P Alienation Mentale ;” the diviiions of which are clear, and the re¬ marks of high practical importance. The prefent writer will be found to have availed himfelf, as far as poflible, of the advantages which this excellent treatiie affords, under the article Insanity, voi. xi. He has not, how¬ ever, been able to make the fame ufe of M. Pinel’s “ Phi- lolophical Nofography.” It is too refined for popular ufe, and too indiftindl for pradlical benefit. The claffes are as follow : 1. Fevers. 2. Inflammations. 3. Adtive Hemorrhages. 4. Neurofes. 5. Lymphatic Difeafes. 6. An indeterminate clafs for the reception of diforders which cannot be received into the preceding claffes, or whofe charadters yet remain to be afcertained. This laft divifion evinces a woeful want of fkill, and is perhaps more reprehenfible than the Locales of Dr. Cullen. M. Pinel has, moreover, betrayed a Angular itch for changing eftablilhed terms which, in many cafes, require no change whatever; and fuperfeding them by others which are neither more true to corredt theory, nor more euphonous to a corredt ear. As examples we may notice, that in¬ flammatory fever is here denominated angi-fienic ; bilious fever, meningo-gafiric ; putrid, adynamic ; malignant, ataxic. In turning our attention to our own country, w-e fhall perceive that the firft attempt to improve on Cullen’s fyftem was hazarded by Dr. Macbride. It was publifhed as early .as 1772, and confifts of nothing more than a nofological table, embracing indeed the divifions of ge¬ nera and fpecies (except in the order of Vefaniae, which is left imperfedt, from an indetermination in the author’s mind upon this fubjedl), but totally void of definitions. It is the opinion of Dr. Good, that this unfinifhed Iketch is well worthy of attention, and has not had fufficient juftice rendered to it. Its chief failure confifts in the nature of its claffes or primary divifions. Thefe confift of four; Universal Diseases, Local, Sexual, and Infantile. The fecond, or local clafs, is evidently de¬ rived from Dr. Cullen, though the term is employed in a ftridler fenfe : and the formation of a clafs of Univerfal Difeafes follows naturally, and indeed neceffarily, from the inftitution of a clafs of Local. A precife line of dif- tindlion, however, can never be drawn by the moft de¬ licate hand ; and it is obvious to every one, that the em¬ ployment of other -claffes after thefe, whatever be their names, ranges, or attributes, muft be abfurd ; for the terms Univerfal and Local neceffarily include every dif- eafe in nature, and leave no other diftindtive clafs to be added. Yet Dr. Macbride appears to have exhibited as nice a fkill in the arrangement of his genera and fpecies, as he has want of fkill in his primary outline. There is a clearnefs, a neatnefs, and fimplicity, which, fays Dr. Good, “ J have endeavoured to avail myfelf of, wherever the ftrudture of my own fyftem w'ould allow, and which I have often left with regret where it would not.” No¬ thing can moreeffedlually fhow the good tafte and liberality of Dr. Cullen, than his Latin tranflation and introduc¬ tion of the firft and moft extenfive clafs of Macbride’s Table into the laft edition of his Synopfis, for the purpofe of comparifon with his own arrangement, as well as with the fyftems of thofe to whom he was moft indebted. Another Table of Difeafes, diftributed under a diffe¬ rent fyftematic arrangement, was publifhed not many years after, by Dr. Crichton ; and, like the preceding, unaccompanied with definitions of any kind. Its claffes are eight, confifting of Cullen’s four, with the addition of four others, for the purpofe of accommodating thofe genera which are chiefly under a ftate of reftraint in the Cullenian method ; and to which he has given the names of H/t.morrhagijE, Fluxus, Intumescentije, and Epischeses. This affuredly offers fome improvement ; but the retained clafs Locales is fubjedt to the common objedfions againlt it; and in the fubdivifions of this clafs Dr. Crichton has no reafon to boaft of being more fuccefs¬ ful than his predeceffors. He feems fenfible, indeed, of the difficulty, and appears to ftirink from it; for in the fourth, fifth, and fixth, orders of the local clafs, entitled Prolapfus, Luxatio, and Tumores, he has withheld his fpecies; and in the three enfuing orders, entitled Vul- nus, Ulcus, and Fradtura, he has equally withheld his genera. For the moft part his generic and fpecific diftindtions exhibit far lefs precifion than thofe of Dr. Macbride, whilft he has moft unaccountably reftored the fymptomatic fpecies of difeafes which Cullen laboured fo meritorioufly to fupprefs. It is fomew'hat Angular, therefore, that Dr. Crichton fliould have belt fucceeded where Dr. Macbride principally failed, and chiefly failed where Macbride has been moft fuccefsful. Dr. PATHOLOGY. Dr. Darnin' s fyftem of nofology, publifhed indeed fome years before Dr. Crichton’s, is founded, not on fymptoms, but on theory. The author of Zoonomia was a man of great genius, daring imagination, and extenfive reading. Seep. 43. Unfortunately for him, he was per¬ petually ftung with a defire of diftinguifhing himfelf by feeing things, weighing things, and combining them, in a manner different from every one elfe. All his works give proof of this; and fliow evidently that he would at any time rather think wrong with himfelf than think right with other people. His nofological fyftem is founded upon his phyiiological principles ; which, ftripped of extraneous matter, may be told in few mords, fo far as they are applicable to the prefent fubjeCf. The brain, as a collective organ, is the fountain of life and fenfation, and fends forth fibres of different kinds and for different purpofes; which are excited, and communicate percep¬ tions to the organ whence they originate, by four diffe¬ rent claffes of ftimuli, thofe of Ample irritation, of fen¬ fation, of volition, and of aflociation ; every part of the animal frame having a greater or lefs degree of influence upon every other part, and operating this influence by the medium offympathy ; in confequence of which, Dr. Darwin was defirous that his own theory fttould take the name of the fympathetic. “ Every idea," fays he, “is a contraction, or motion, or configuration of the fibres which conftitute the immediate organ of fenfe;” and hence it feems difficult for the friends of Dr. Darwin to repel the charge, that ideas, under this explanation, mult be ma¬ terial fubftances. Health he contemplated as confifting in the natural correfpondence, and degree of correfpon- dence, of the various organs of the body to their respec¬ tive ftimuli, and difeafe as an effed produced by any, even the flighted, deviation from fuch correfpondence in any part. Hence every fuch effed, in his opinion, conftituted a difeafe; and what is commonly fo denominated, and which confifts of a combination of fymptoms, as a fever or a colic, he regarded as a group or bundle of dileafes ; a fort of Pandora’s box, where they mufter their fecret or collective ftrength, and whence they iffue fimulta- neoufly. In forming his nofological arrangement, he made thefe effects, and the parts or organs in which they manifeft themfelves, conftitute his genera and fpecies ; while he derived his claffes and orders from their proxi¬ mate (or rather what upon his theory are fuppofed to be their proximate) caufes, and the peculiar characters which thefe caufes exhibit; the number of the clafles being four, derived as may be eafily conjeCtured from the four fpurces of ftimulation juft referred to. “ I have taken,” fays Dr. Darwin, “ the proximate caufe for the claffic cha¬ racter. The characters of the orders are taken from the excefs, or deficiency, or retrograde aCtion, or other pro¬ perties, of the proximate caufe. The genus is generally derived from the proximate effed. And the fpecies gene¬ rally from the locality of the difeafe in the fyftem.” By proximate caufe, however, Dr. Darwin does not mean what is generally underltood by this phrafe, namely, the molt ltriking or charaCteriftic fymptom of a difeafe ; but what Ihould feem to be the proximate caufe upon his own theory, and which in every inftance mufi be a differ¬ ent and often a direCtly oppofite thing. Thus in nicti¬ tation, the proximate caufe, in the common fenfe of the term, is a “ rapid and vibrating motion of the eye-lid,” which ought, therefore, to conftitute the character of the diforder. In the vocabulary of Dr. Darwin, however, this, inftead of being the proximate caufe, is the proximate effed ; while his proximate caufe is “increafed irritation,” which is the remote caufe, as the phrafe is commonly ex¬ plained. We are not now inquiring which is the more correCt ufe of the terms caufe and effeCt, but only pointing out the variance and the confufion that hence neceffarily enfue. The perplexity hereby produced rnuft have been an effectual bar, had there been no other, to Dr. Darwin’s fyftem ever becoming popular. Unfortunately there are many others, and of as formidable an afpeCt. The en¬ tire bafis is theoretical ; in feveral parts vifionary : the whole may, therefore, prove hereafter to be unfounded ; a confiderable portion of it evidently is unfounded at prefent. But the direCt death-warrant of the fyftem con¬ fifts in his making every Angle proximate effed (in com¬ mon language proximate caufe, or fymptom) a diftinCl difeafe ; for, as the fame proximate effeCt, or fymptfc>m, may be produced by feveral, or by each, of what Darwin calls proximate caufes, and which conftitute his claffes, it follows that the very fame fpecies or fpecific difeafe mu ft in fuch cafes belong equally to fome order or other of feveral or of all the clafles of his fyftem. And fuch, to the ftudent’s embarraffment and furprife, lie- will find upon examination to be the real faCf. Thus while Va- liola (fmall-pox) is arranged under cl. ii. ord. 1. gen iii. Eruptio Variolas (fmall-pox eruption) occurs under cl. iv. ord. 1. gen. ii. So Hydrophobia appears firft in i. 3. i. and afterwards in iii. 1. 1. Diabetes in i. 3. ii. and again in iv. 3, 1. Palpitation of the heart in i. a. i. and again in i. 3. iii. being twice in the lame clafs : and fo of many others. Such perplexity fets all the ordinary laws of method at defiance ; yet it is eafily accounted for from the nature of the primary divifions. While, to make the fyftem ftill more defective ‘and incapable of practical ufe, its author has given us neither his fpecific nor his generic definitions, excepting, indeed, occafionally ; confining himfelf en¬ tirely to his Latin and Engliffi names ; and fending us for their deferiptions to “ the Nofologia Methodica of Sauvages, and the Synopfis Nofologise of Dr. Cullen, and the authors to which they refer.” But fuch an appeal can be of no poffible fervice : the difeafes in Darwin’s fyftem do not run parallel with thofe referred to, and the deferiptions will icarcely in any inftance apply. In the very excellent Medical Dictionary of Dr. "Parr, which has now been about twelve years before the public, the reader will find, under the article Nosology, a fyl- tematic arrangement of difeafes which ought by no means to pafs without notice. In laying down the outline of his fyftem, Dr. Parr had his eye chiefly directed to the nofological method of Selle, and the botanical method of Juffieu. It follows, there¬ fore, that his primary divifion would confift not of claffes, but of what he intended to be natural orders, or families. Thefe orders are twelve, whofe names are taken from the clafles or orders of Sauvages or Cullen, with the excep¬ tion of one, Suppressor.ii, which is borrowed from Lin¬ naeus. Here again, therefore, we have a great and noble aim, whatever be the fuccefs of its accomplifhment. But, as a natural fyftem, even in botany, is to the prefent hour, and perhaps always will be, a theoretical rather than a practical idea, there feems very little expectation that it can ever be realifed in medicine. On the part, therefore, of Dr. Parr, the attempt was a bold one ; and his arrange¬ ment will ffiow that, if he has not been altogether fuc- cefsful, he has exhibited a very confiderable degree of ingenuity. This arrangement is as follows : Pyrexia, Fevers. Phlegmafia, Inflammations Eruptiones, Eruptions. Profluvia, Fluxes. Supprejj'orii, Suppreffions. Spajmi, Spafms. Adynamia, Debilities. Paranoia, Alienations. Cachexia, General Diforder. Intumefcentia, Tumours. Edopia, Protrufions. Pluga, Wounds. Between moftof thefe we can trace, in the feries of their defeent, a verbal connexion ; and between feveral of them a connexion of a more fubftantial kind. It holds nomi¬ nally in the firft three orders, but feems to flip from us in the three that follow ; and is occafionally recovered in the remaining. Yet, when we examine the genera and fpecies of the refpeCtive orders, we fliall find the con¬ nexion is too commonly nothing more than verbal. Phlegmasia has a manifeft relation to Pyrexia ; but in Caeliaca, Leucorrhcea, Leucorrhois, (difeharge of white mucus 86 PATHOLOGY. mucus from the anus,) which are difeafes of the former order, the connexion is entirely loft: nor will it, per¬ haps, meet with general approbation that thefe, together with Gonorrhoea (ufed in the vulgar fenfe of the term), Cyftirrhcea, and Phthifis, (hould be united with Coryza and Dyfentery, under one common genus, to which is given the name of Catarrhus. This, however, is a genus upon which Dr. Parr peculiarly prided himfelf, and upon which he unqueftionably bellowed very great pains. In like manner the order Eruptiones feems at firft to claim a near affinity with Phlegmasia ; and in the genus Ex¬ anthema it does fo fubftantially, -for here we can trace diftinCtly fomething of that febrile, or, to fpeak more cor¬ rectly, pyreCtic diathelis, which unites thefe two orders with the order Pyrexia. But in the mere cutaneous eruptions, here collected into one genus, named Efflo -. rf/ceniia, the line of union becomes fo fine and filmy as to be altogether invifible. Were we to purfue this prying indagation, we fliould foon arrive at breaks far wider and more obvious. It would perhaps be difficult to find four difeafes more difcrepant from each other than Dyfpepfia, Amentia, Amaurofis, and Agenefia. They feem to have no one common property with each other. Dr. Parr, however, has contrived to make them all fpecies of a fingle genus, to which he has given the name of Anepi- thi/mia, and which he has defined, “a diminution of power in the different functions a character fufficiently (weep¬ ing to cover at leaft half the difeafes that man inherits ; for excefs and diminution of power may eafily he made to embrace the whole; and are made to do fo under the Brunonian theory. Yet, notwithftanding this licentious generalization, and aim at a natural arrangement, the difeafes of the external fenfes, which feem to have a pretty clofe proximity with each other, are partly fcattered at conliderable diftances over the entire fyftem, and partly, as in the inftances of Caligo, Dyfopia, Paracufis, Anof- mia, Ageuftia, and Antefthefia, are in the unfortunate fituation of Dr. Cullen’s “ Catalogus morborum a nobis omifforum and, from forgetfulnefs orfome other caufe, have no place allotted them in any feCtion of the fyftem. There is, neverthelefs, much in Dr. Parr’s fyftem that is highly meritorious. The diftinCtions of the different divifions are fcientifically laid down ; and, except that the genera are occafioually too extenfive, accurately maintained. Dr. Parr gives the following fhort explana¬ tion of his own fyftem : “ In this arrangement there is a concealed methodus, which, as it is notan objeCt of importance, we need not explain farther than by adding, that feverilh complaints, increafed and diminillied eva¬ cuations — increafed, diminifhed, and irregular, nervous excitement — difeafed fluids, appearing either in increafed or diminifhed bulk— the difplacements and folutions of continuity — follow in order.” Dr. Young's “ Introduction to Medical Literature, in¬ cluding a Syftem of Practical Nofology,” though limited to a fingle oCtavo, ranges through an entire courfe of medical education, anatomical, pathological, therapeuti¬ cal, and chemical, as well as nofological; whilft in the laft department it is drawn up with a fomewhat different view, and is more ft riCt ly limited to the pale of the me¬ dical profeifion. The arrangement of Dr. Young, while effentially diftinCt from that of Dr. Good, will be found perhaps to make the neareft approach to it of any that lias hitherto appeared. In wanting the divifion of orders to two of its clafles, it is fcientifically defective ; but its fyftemntic boundaries are as clearly feen, and as precifely maintained, as thofe of Dr. Parr. Yet its chief merit, perhaps, confifts in offering to the ftudenta mafterly gui¬ dance, through the whole of his profefiional tuition, to the heft authorities and fources of information ; in this refpeCt anfweringthe purpofe of Plouquet’s feven quarto volumes, with a great faving of expenfe, a prodigious laving of time, and by a far nearer and pleafanter path¬ way. A glance has already been given atafevv limited nofo¬ logical arrangements, by writers who have confined their attention to a fingle family or group of difeafes, detached for this purpofe from the reft; and to this defcription of works Dr. Good has applied the name of monograms. To the names of Selle, Pinel, and Crichton, it is neceffary to add, under this view of the fubjeCt, thofe of Plenck, Willan, Bateman, Abernethy, and Granville. Dr. Plenck, of Baden, is the author of two diftinCt treatifes of this kind; the one a methodical arrangement of the “ Difeafes of the Eyes and the other of “ Cuta¬ neous Difeafes.” In the former he follows the order of anatomy in the diftribution of his primary divifions, be¬ ginning with the eye-brows, and defcending from with¬ out inwards till he clofes with the retina. In the latter, which confifts of clafles, genera, and fpecies, without the interpofition of orders, he employs a loofer line of fuccef- fion; though the general idea feems to be that of advanc¬ ing from the (lighter to the more prominent elevations of the (kin, commencing with Macula, and proceeding to Excrescentia ; the remaining clafles confiding of Cu¬ taneous Ulcers, Wounds and Insects, Diseases of the Nails and of the Hair. He is a more induftrious than difcriminative writer, as the reader will perhaps readily concede, when informed that he has arranged, defined, and followed, through their progrefs and mode of treatment, a hundred and nineteen genera, comprifing very nearly fix hundred fpecies, or diftinCt difeafes of the eyes, the genus amaurofis alone extending to twenty fpecies; and one hundred and fifteen genera, including nearly fix hundred fpecies, or diftinCt difeafes of the (kin. Yet compreffion, and a more fcientific arrangement, would make either of Dr. Plenck’s attempts a valuable work ; and Dr. Willan has the merit of having performed this friendly office to the latter of the two, in his book on “ Cutaneous Difeafes;” and at the fame time of hav¬ ing added fo much valuable matter of his own, as to entitle it to the claim of being ftriCtly an original per¬ formance. The diftinftive characters of papula, puftule, veficle, bleb (bulla), fcale, and cruft, are well given and maintained by the former; but the latter has exprefled them more neatly, and has added many diftinCtions which the former does not afford ; whilft he has drawn his literary and practical hiftory, and treatment of the dif¬ eafes difcuffed, from very different fources ; and, as far as might be, from his own perfonal obfervations. That Dr. Willan did not live to finiffi this valuable work muft be regretted by every one who has the welfare of medi¬ cine at heart ; but the able and judicious manner in which it has been brought to a clofe by Dr. Bateman has ferved in no fmall degree to abate the general difappointment. Had Dr. Willan lived to complete the direCt objeCt of his purfuit, and then extended his views to the whole circle of difeafes, he muft have greatly modified his firft and more reftriited fyftem before he could have incorporated it in the larger plan. As it is, indeed, it (lands in need of no fmall degree of modification to clothe it with all the perfeftion it deferves ; for feveral of his orders would make better genera almoft all his genera are decided fpecies, while his fpecies are feldom more than varieties, and are in many cafes fo denominated by himfelf. In this refpeCt he might have taken a good leffon from Dr. Young, Dr. Parr, or Dr. Macbride ; as he might alfo from the two former in giving the eflential character of each dif- eafe antecedently to the admirable defcription with which it is followed up. The name of Mr. Abernethy is here mentioned in refe¬ rence to his methodical “ Claflification of Tumours.” This claflification is ltriCtly fymptomatic, the characters being derived, as they ought ever to be, as much as poffi- ble, from fenfible phenomena. The laft monogram we have to notice is a “ Claflification of the Difeafes of Children,” by Dr. Granville, principal phyfician to the Royal Infirmary for Sick Children ; and detailed by him in the London Medical Journal for De- 3 cember 87 PATHOLOGY. cember laft (1820), of winch work he is at prefent the editor. Dr. G. in his addrefs to the then editor, obferves, “ You mud have been ftruck, in common with every other practitioner of this or any other country, with the fingular circumftance of no regular claffification of infan¬ tile difeafes having ever been propofed by the feveral eminent authors who have written on that particular branch of medicine ; and you will probably agree with me, that no-where is the neceility of fuch a claffification ' likely to be more felt than in an extenfive inftitution di¬ rected folely to the alleviation of thofe difeafes, where daily and numerous occafions mutt occur for its ufe. In the Infirmary to which I have had the honour of being appointed principal medical officer, it would fcarcely have been poffible for the phyficians and furgeons belonging to it to have preferved any degree of uniformity in the medical records of that inllitution, had we relied on the ufual routine only, of entering the names of patients without any very precife and uniform defignation of their complaints. It became, therefore, necefl'ary to efta- blifh fomething like a Synopfis, by the help of which, as if with the ufe of a common language, we might become intelligible, not only to each other but alfo to the profel- fion in general; the members of which may hereafter wifh to refer, for many ufeful fubjefts of information, to the regifters of the Royal Infirmary. “ How far the prefent attempt to form fuch a Synopfis may fucceed in removing the difficulties which, like thofe experienced in general pradtice before any nofolo- gical arrangement of difeafes had been eftablifhed, muff be felt in the confideration of infantile complaints, I leave my colleagues and the public to decide. I have no pre- tenfions on the fubjeCt, and I give my prefent fpeculation as a mere attempt; happy if it ferve to ftimulate more competent perfons to fill upthechafm which has hitherto exifted in nofological fcience. The names of Heberden, Rofen, Capuron, Burns, and Underwood, not to mention feveral others, muff be familiar to thofe who have paid particular attention to the difeafes of children. The de- fcriptive obfervations and pradtical remarks of thefe emi¬ nent men leave fcarcely any thing to be wiflied for; yet it muft be admitted that, had thofe defcriptions and re¬ marks followed fome fpecific arrangement, the facilities for their ltudy and their retention would have been greater than they now are. “ The plan of the prefent claffification is as follows : I have, in the firft place, confidered all deviations front healthy adlion or healthy ftrudturein children, as having either begun with their fetal life and formation, or deve¬ loped themfelves at the moment, and in confequence, of parturition. Thefe, therefore, form a firft great divifion, very diftindl from that of any other complaint w-hich may afflidt a child fubfequently to its birth and up to the adult age. To this firft great divifion, I have'applied the deno¬ mination of Morbi Congenili, and I have necefi'arily been obliged to make two -clafles of it; in the former of which I have placed all difeafes or deviations from healthy ftrudlure previous to, and confequently independent or, parturition ; wdiile in thefecond thofe congenital difeafes have been arranged which are connected with, cr depen¬ dent on, parturition. The difeafes embraced by the firft of thefe two clafles of the firft great divifion are by far more numerous than thofe of the fecond clafs ; and, in order to facilitate their recollection, they have been fub- divided into ten orders, each order containing an unequal number of genera, in all forty-five. Two orders only are contained in the fecond clafs : i, topical ; 2, univer- fal ; each being fubdivided into five genera. “ Having thus difpofed of all the difeafes which, from their being coeval with the patient, form a well-defined and diftindl divifion, it remained for me to arrange all thofe deviations from health which are known to "occur fubfequently to birth and as late as the adult age, whether peculiar to the period of time that lies between thefe two Vol. XIX. No, 1289. epochs, or likely to affedl children in common with per¬ fons more advanced in years. Thefe two confiderations gave rife to a fecond great divifion, which I have defig- nated by the name of Morbi SubJ'eqtienles,a.% quite diftindl from thofe which formed the fubjedl of the preceding remarks.” This fecond great fedlion is divided into four clafles, and each clafs into two orders ; the genera are 96, which added to 55 in the firft grand divifion, make a fum of 1 51 genera of difeafes with which children are afflidted. How numerous the particular fpecies may be we are left to conjedlure, as the author fays, “ I have not extended my confideration to either fpecies or varieties, as this would have carried me too far.” This Synopfis has been printed on a card, for the con¬ venience of lludents. Omitting the names of the genera, the claffification will appear as follows : I. Morbi congeniti. Clafs I. Atocica. Congenital Difeafes independent of Parturition. Order 1. Atrefis. Natural openings imperforate. 2. Collifis. Unnatural adhefions. 3. Hiazeuxis. Unnatural feparations. 4. Elatojls. Defective organization. 5. Perifleuzis. Superfluous organization. 6. Hydrops. Unnatural accumulation of fluids. 7. Edopiee. Difplacements. 8. Affymetria. Anti-fymmetrical conformation. 9. Purcejlhefis. Defedlive adlion of fenfes. 10. Metrocehs. Marks. Clafs II. Tocica. Congenital Difeafes dependent on Parturition. Order 1. Topici. Partial. 2. UniverJ'ales. General. II. Morbi subseouentes. Clafs I. Zotica. Morbid Alterations of the preferva- tive Fundtions. Order 1. Pneumalici. Affedling refpiration. 2. Hcematici. Affedting circulation. Clafs II. Auxitica. Morbid Alterations of the augmer.- tive Futidlions. Order 1. Cccliaci. Affedting digeftion. 2. Lymphatici. Affedling abforption. Clafs III. Apocritica. Morbid alterations in the fegre- gating Fundtions. Order 1. Eccritici. Alfedting fecretion and excretion. 2. Hermatici. Affedting exhalation. Clafs IV. AUsthetica. Morbid Alterations of the fen- fiti.ve F undtions. Order 1. Ncurotici. Affedting fenfation. 2. Myolici. Affedting voluntary motion. We hail the eftablifhment of an Infirmary for Sick Children, as likely to form a new era in favour of the rifing generation ; for we cannot doubt that it will havb its effedl in improving a branch of medical pradtice, of which it is not too much to fay, that it has hitherto been unaccountably negledted. “ In no department of our profeffion (fays Dr. Reid) does the pradtice of it appear fo cruelly abfurd as in the mifmanagement of infants. I once ventured to obferve, that, of the cafes of mortality in the earlier months of our exiftence,nofmall proportion confifts of thofe who have funk under the oppreifion of pharmaceutical filth. More infantile l'ubjedts in this me¬ tropolis are perhaps diurnally deftroyed by the mortar and peftle, than, in the ancient Bethlehem, fell vidtims in one day to the Herodian mafiacre. I plead guilty to the charge of rafhnefs and hyperbole, which were brought againft this remark when firft publiffied ; but I wifh that the years of experience, which have fince intervened, had convinced me that the remark was altogether deftitute of foundation. When we contemplate a church-yard, the earth of which is compofed in great meafure of the bodies of infants, it is natural for us to fancy, but furely it is A a not 88 PATHOLOGY. not reafonable for ns to believe, that t-hofe beings were born for no other purpofe than to die; or that it is within, the defign of nature that the pangs of production on the part of the mother fltould, on that of her offspring, be almoft immediately fpcceedbd by the ltruggle of diffblu- lution. Fault mud exilt fomevvhere : it cannot be in the providence of God; it mu ft therefore -attach to the im¬ providence and indifcretion of man. Confequences as fatal originate from ignorance as from .crime. Infanticide, when perpetrated under the impulfe'of maternal defpera- tion, or in the agony of anticipated difgrace, is a fubjeft of aftonifhment and horror ; but, if a helplefs viftim be drugged to death, or poifoned by the forced ingurgitation of nauleous and effentially-noxious potions, we lament the refult merely, without thinking about the means which inevitably led to its occurrence. Confcience feels little concern in cafes of medicinal murder. The too- ordinary habit of jelling upon thefe fubjefts in convivial or familiar converfation, has an unhappy tendency to harden the heart, and inclines us to regard, with an inhu¬ man and indecorous levity, thofe dark and horrible cataf- trophes which too frequently arife from profeffional igno¬ rance or miftakeT Efiays on Hypochondrialis ; 2d edit. 1821. Some other fyftems of inferior importance have appeared in different countries, efpecially in Germany. We pafs over them, however ; and, difmifting this uninterefting branch of our fcience, retrace our Heps to conlider the moll important of the modes in which difeafe, or a change from the phenomena of healthy action, may arife. An inquiry into the abllraft principles of difeafe is a fubjeft of acknowledged difficulty. The very definition of the word difeafe involves more trouble than might at firft feem apparent, and is indeed a matter about which there exifts much difference of opinion. We content ourfelves, therefore, with the life of the laconic definition, that difeafe is the abfence of health, acknowledging, how¬ ever, that this defcription involves the definition of what health is. But the latter queftion is anfwered by Phyfiology, a fcience with which the . pathologift is fup- pofed to be previoully acquainted. We do not propofe to enter into a confideration of the minute and remote caufes of difeafe. It would not per¬ haps be difficult to lhow, that the firft changes which take place in the various ftruftures mull operate by their relation with the vital properties. This, of courfe, ap¬ plies principally to thole caufes which produce what is called the predifpojition to difeafe. A predij'pofing cuvj'e is that which renders the body liable to be attacked by dif¬ eafe, or to be afted upon by an exciting caufe ; for the operation of an exciting caufe alone is generally not fuf- ficient to produce difeaie. Thus feveral perfons may be expofed at thefame time to the fame external agents, e. g.* to cold and moifture : in forne, thefe agents will excite difeafe ; on others they will aft with impunity. In the former perfons, fome circumftances mull have exifted which rendered them liable to receive thofe morbid im- preffions; in the latter, no fuch predifpofition was pre- fent. Again, fome of thofe, whom the exciting caufes affefted, may fuffer one kind of difeafe, and others a dif¬ ferent one; thus, one individual may be afflifted with rheumatifm, another with catarrh, a third with dyfentery, and fo on ; fafts implying the exiftence of fome peculiar condition of the body, or of the organs refpeftively at¬ tacked, w hich is juftly deemed a predifpofing caufe of the particular malady which may have occurred. In fome inftances, the predifpojition is obvious and well under- ftood : thus one attack of rheumatifm, pleurify, or any inflammatory diforder, generally renders the body more liable to fuffer a fecond : a peculiar formation of thecheft, combined with a fair and delicate fkin, with dark eyes, lively fpirits, &c. implies a tendency to be affefted with pulmonary confumption : and a plethoric habit, large head, Ihort neck, very florid complexion, &c. threatens the acceffion of apoplexy. In fuch circumftances the kinds of exciting caufes, which ought to be peculiarly avoided, are manifeft ; and by a careful attention to this fuggeftion, the difeafes, with which the individuals are menaced, may be often avoided. The exciting is the next mode of remote caufation, and is of courfe an agent which operates for the moll part by the relation it holds with the predifpofing caufe. The ex¬ citing caufes of difeafe have given rile to many and va¬ rious hypothefes. Hippocrates fuppofed that diet and air were the externals whence difeafe w\as principally de¬ rived ; and certainly, as thefe are the pabula vita:, as they conllitute the repair necefiary to our exiftence, an unufual Hate of them mull produce a correfponding change in the fenfations and funftions of our bodies. We can only therefore add to thefe exciting caufes, mental impre.ff.ons and exceffive aftion, or the reverfe, of certain organs. But there are fome exciting caufes fo very generally af- fefting mankind as to lead us to fuppofe that they operate independently of any ftate of predifpofition ; as the poifon of fyphilis, fmall-pox, rabies, &c. Though even thefe difeafes do not feem uninfluenced by the Hate of confti- tution, as they exilt in various degrees of intenfity in different individuals. As thefe exciting caufes of difeafe can come only from without, they mult operate in the firft inltance through the medium of thofe parts by which man is related with the external world. Thefe are the organs of fenfe, and thofe unions of the three fundamental ftruftures which have been denominated the alimentary canal , the pulmonary cavity, and the cutaneous expavjion. As thefe three ftruc- tures are all affimilation or abforption, and at the fame time abundantly fupplied with nerves, they mult commu¬ nicate morbid impreffions, either, ill, by ailimilating fub- llances of an improper nature ; of which we have frequent inftances in the reception of poifons, &c. into the blood, in thetranfmiffion of the marlh miafmata, or the contagion of fevers, &c. or 2dly, by tranfmitting nervous impreffions to the brain, and inducing diforder of that organ, and the nervous fyllem generally. Each of thefe modes may, ac¬ cording as predifpofing caufes are in exiftence,' produce local difeafe, or dilturbance of general funftions. But it is very obvious, that, however firmly thefe no¬ tions may be eftablilhed, we advance but a very little way in attaining a knowledge of exciting caufes. Bor, fo various are the modes by which externals may operate, fo many infcrutable and various properties belong to food, and Hill more to air, and fo numerous mull be the derangements produced by nervous excitation, that the attempt to trace the law's of thefe caufes will for ever re¬ main inefficient. The operation of the fenfes can of courfe only induce diforder of the brain and nervous fyllem by exhaulling its energies ; whether that exiiaullion be produced by excitement of the brain generally, or of its particular parts ; or, on the other hand, by the depreffion of them. To illuftrate thefe principles, we will fuppofe a patient afflifted with a ftate of the liver predijpojc.d to difeafe. Is mental emotion by exceffive grief, that is to fay, is the produftion and tranfmiffion of nervous energy, dillurbed by the inordinate aftion of the brain? the procefls of fecretion in the liver will be obftrufted ; and thus induce firnple local plethora, perhaps the fimpleit form of difeafe. On the other hand, difeafe may occur in the predij'pofed liver by the immediate application of an improper mate¬ rial received into the blood, and afting as an unufu'al Itimulus to the contraftile power of the capillary velfels of the liver; hence, in the fame way, impeding fecretion, &c. Of the application, however, of thefe doftrines, we fhall have occafion to give very frequent illuftration in the pathology of particular difeafes. We have now to conlider the nature of what is called the proximate caufe of difeafe. The precife meaning attached to this term is, that it delignates an adtion of the body, in contra-dil- tinftion to Hates of impreffions which conllitute remote caufes. PATHOLOGY. 89 caufes. The proximate caufes, therefore, of difeafes, muft be alinoft as numerous as the difeafes themfelves ; and hence they will form part of the pathological dif- cuflion we (hall enter into with regard- .to each different malady. In this place, however, it will be proper to of¬ fer fome remarks concerning the local origin of difeafe. That difeafe may, and indeed generally does, arife from lofs of the balance of abfion between one part and the fyf- tem at large, feems indifputably proved. How far, how¬ ever, this part may proceed in difeafed action without influencing the general health, is another and an impor¬ tant confideration. Having lately met with fome re¬ marks on this head by Mr. Pring, we have tranfcribed them from his “ Indications,” on account of the clofe reafoning with which he has illuftrated the fubjedf. “There are but few (perhaps not any) examples of difeafe which is confined wholly to one part. There are many inftances of difeafe of one part, in which the or¬ ganic fyftem elfewhere does not perceptibly fuffer : but thefe are attended with pain or difordered motion, which is fufficient to prove an extenflon of the difeafed (fate. In the organic fyftem, however, a perfon may have an ulcer in the leg, or a tumour upon the (boulder, or an herpe¬ tic difeafe upon fome fpot of the (kin, or a ftricfure of the urethra, & c. without any fenfible derangement of the fame fyftem elfewhere. But even in thefe inftances we cannot prove that the change is entirely local, unlefs it may be fliown, ift, that the natural condition of the feat is not a dependent one, by which diforder might origi¬ nate in another fphere ; and, ad, fuppoflng the difeafe fo originate in its apparent feat, that no other is fo con- nedled with it as to participate in its modifications. But, if it is poflible that any part (hould poflefs only an affimi- lating life, that no other part is dependent upon it, and that the condition of difeafe does not open any new or preternatural relation, then it is poflible that the affimi- iating life of fuch part may become exclufively difeafed. “ It happens however in moft inftances of difeafe, that this ftate prevails in more than one feat. In fuch in¬ ftances thefe two alternatives are to be difcriminated : ift, Whether the difeafes occupying different feats are not independent of each other? ad, Whether the pri¬ mary produces the fecondary difeafe ? “Jf in the courfe of a fever an abfcefs fliould form in one axilla, and a week afterwards an abfcefs (hould form in one groin ; if the eruption of the fmall-pox (hould ap¬ pear firft in the face, and then be extended over the whole body ; if a tubercle fliould form in the liver, and a month afterwards a vomica fliould burft in the lungs ; if a vene¬ real ulcer (hould form in the throat, and fix weeks after¬ wards a node on the tibia; we fliould fcarcely in thefe (and there are many fuch) cafes affert that the difeafe occupying the firft feat was the caufe of the difeafe occu¬ pying the fecond. “But, if one half of the body fliould be paralyzed by the rupture of a blood-veflei ot the brain ; if vomiting (hould fucceed to a blow on the head ; if difordered ref¬ piration fliould fucceed to the operation of a caufe of prefi'ure on the brain ; if atrophy fliould fucceed to difeafe of the mefenteric glands; if the fecretion of a gland fliould be fufpended during an inflammation of it ; if convulfions fliould fucceed the irritation of a nerve ; if paralyfis of the fphi abler of the bladder fliould fucceed to an injury of the (pine. See. — vve have no hefitationin thele cafes in affirming that the primary is the caufe of the fe¬ condary affeblion, becaufe we know that the healthy ftate of the properties engaged in the fecondary, acknowledge the regular dependent relation with thole engaged in the primary feat of affeblion. “ Again, if vomiting fliould fucceed the formation (or introdublion) of a calculus in the gall-duff, or to the pafling of a calculus along the ureter ; or if a pain in the fhoulder (hould fucceed an inflammation fet up in the liver; or if hernia humoralis fnould fucceed to an affec¬ tion of the urethra, perhaps produced by an injeblion ; or if tetanus fliould follow a punblured or lacerated wound ; or if pain in the breads (hould fucceed concep¬ tion, &c. — we have in thefe cafes no hefitation in faying, that the fecondary is produced by the primary change. “ Thefe are examples of the claffes of related difeafe. Difeafe of one part, or one ftate of difeafe, might produce another ; ift, by difturbing an habitual dependence ; and, 2d, by the influence of an occafional caufe. The firft: is illuftrated above; as if an injury of the brain fliould pa¬ ralyze nerves whofe functions are dependent upon the brain, or as if refpiration fliould become laborious, or perhaps ceafe, by the operation of any caufe of prefl'ure upon the brain, &c. The fecond is illuftrated in thofe other examples, in which a relation is exhibited under circumftances of difeafe, which was not manifefted as one of dependence for a natural office, during health. “ The affeblion of a dependent feat in confequence of a difordered ftate of the feat from whence its functional properties are derived, is by no means a regular occur¬ rence. We know that there might be a violent pain in the head, a throbbing of all its vefl'els, as if the whole brain was violently difordered, and yet the funblion of refpiration, which depends upon the brain, may be but little or not at all interrupted ; at the fame time, a flight prefl'ure upon the brain (hall impair or prevent thefe de¬ pendent functions. The reafon is, that properties are not indifferently related with any caufe of diforder ; but their relations are precil'e ; as, properties of the brain animate the organs of refpiration, thefe properties related with the agency of prefl'ure, not related with caufes merely produc¬ ing pain or even inflammation ; the dependent function, impaired by the former, becaufe the former is related with the properties engaged in the dependence; not re¬ lated with the latter, becaufe, although they produce a certain affeblion of the feat of the properties which ani¬ mate the refpiratory organs, they do hoi; produce a change in the nature and relation of thefe properties, to expebl which would be like expebling that paralyfis of nerves fliould not occur from prefl'ure upon a part of the brain, becaufe it ftill retains fome properties of life. “ It has been dated that related difeafe happens in two ways, which may here be repeated : ift, by difturbing an habitual relation of the regular dependent kind ; 2d, by a new relation which is opened between parts not before connebled by intercourfe of funblion, in confequence of a new condition which one of them has affumed: it has been (fated (and examples given) that difeafe might oc¬ cupy a fucceffion of feats without the exiftence of any caufative relation between them.. It is neceffary, before we proceed any further, to inquire after the method of diftinguiffiing between difeafes which, though occurring in a (eries, are independent of each other, and thole in which the fubfequent is produced by the preceding difeafe. , “ In making this diftinblion we are liable to frequent error: the only grounds of the diftinblion, however, are as follow. Mere fucceffion, as has before been infilled, can never prove caufation : but it indicates caufation, from the analogy of fuccelfion to thofe palpable in¬ ftances of caufation in which the dependence of the effedl upon the afiigned caufe may be proved by the re- fult of analyfis and of fynthefis; of taking away (or withholding), and of combining, the caufes. Succeffion then, upon this ground of analogy, which has been more fully explained, may indicate caufation ; and yet we do not fuffer every inftance of fuccelfion to fugged ever fo faintly an inference of caufation. “The fucceffion of an eft'ebt to its true caufe is invari¬ able : from analogy in this refpebt, we infer pofitively the operation of a caufe in all inftances of invariable fucceffion; thus, day and night invariably fucceed the prefence or abfence of the fun. But we prefume ftill further upon this analogy; we infer the operation of a caufe, when the fucceffion of the fame confequence to the fame antecedent is frequent, but not invariable; thus, an ounce and a half 00 P A T H O half of laudanum taken into the ftomach will commonly, but not always, produce death ; we have no hefitation in afiigning the laudanum as the caufe of death, in thofe inftances in which death takes place, notwithftanding there are other inftances where the obvious circumftances are alike, in which it is not followed by death. Inva¬ riable fuccejfion bears fo ftrong an analogy to caufation, that we fcarcely fufpedt the pofiibility of our being de¬ ceived in an inference grounded upon it ; and yet we do fometimes make a falfe inference founded upon paft inva¬ riable fucceftlon, as is proved by additional, or fubfe- quent, experience. Frequent fucceftlon of like to like, bears an analogy to the invariable, and upon this analogy we found an inference of caufation : the point of ana¬ logy is between the frequent and the invariable , confe- quently the analogy mult be eftabliftied or prefumed upon, in proportion to our experience of the frequency of the fucceftlon of like confequences to like antecedents. Thefe grounds of the inference of a caufe, as is juft ftated, are imperfedt, and rnuft admit frequent error; for we cannot define what number of fuccelftons of like confequences to like antecedents, are an adequate num¬ ber to prove caufation. Hence then, although we in¬ fer caufation from fucceftlon, we are obliged to confefs that we can do this only in certain cafes; before we can admit the truth of an inference of caufation, we muft have iiad an experience of a fufficient frequency of a like fucceftlon. Different men will hold different opi¬ nions with regard to what conftitutes a fufficient fre¬ quency, and the want of a poftible definition in this matter admits a great diverfity of opinion upon impor¬ tant points, and gives room for the diftindtion of clofe and loofe reafoners. But, when once we have had expe¬ rience of what is confidered a fufficient frequency of like fucceftlon, wejhen infer fome difference (where it is not perceptible) in cafes in which the fame confequences do not fucceed the fame antecedents. In fuch inftances, we balance an account between like and diflimilar fuc- cefilon ; and we affign a caufe only where the frequency of the fame fucceftlon (approaching to the invariable ) exceeds that of the exceptions. Thus, (not to quit our fubjedt,) if the exhibition of a particular medicine fliould be followed by recovery from phthifis pulmonalis in one inftance, this fucceftlon would, where men are difpofed to catch at ftraws, indicate a poftible caufation ; if the fame event fucceeded to its exhibition in ten in¬ ftances, its credit would be better fupported ; if in a hundred, better Hill. If it fliould fucceed in five and fail in five, we fliould hefitate perhaps tc aftign it as the caufe of recovery in the firft five; if afterwards it fliould fail in fifty cafes, we fliould fay that in the five in which it W’as followed by recovery the cure was owing to oilier caufes. If it fliould fucceed in a hundred and fail in fifty, we fliould then perhaps judge the hundred to amount to an adequate number to eftablifli the relation of the medi¬ cine, as a caufe of recovery ; while we fliould explain its failure in the other fifty, by fuppofing fome diverfity of circumftances, by which its relation as a caufe was modi¬ fied, to have prevailed. The conclufion amounts to this : We infer that a fecondary is produced by a primary dif- eafe, upon an experience of a frequent fucceftlon of the one to the other, provided at the fame time that our ex¬ perience furnifhes us with no ftronger analogies to fenfi- ble caufation, by which we are rather juftified in confi- dering them diftinft.” Pring, ch. iv. This fucceflion of difeafed actions in many difeafes pro¬ duces acurative effedl; and the contemplation of this fadtis what has caufed fo many errors to be committed in practice in regard to the operation of nature. Seeing that thecon- ftitutional difturbance produced a reftoration of health in local difeafes, Hippocrates, and thoufands fince his time, liftve been led to the adoption of that inert practice em¬ phatically termed the “ Medicine expcdlante." It has always been a popular dodtrine, and it is one that carries a great deal of plauflbility in the face of it, that the LOGY. main objedt and the fum total of the powers of medi¬ cine, confift in aiding the natural efforts of the conftitu- tion for the removal of difeafes. But this propofltion requires confiderable qualification. If it be merely meant, that medicine can only operate through the medium of the powers or energies of the living body, and that, in¬ dependently of thefe vital energies, medicine has no operation, the pofition is a truifrn which cannot be quef- tioned. But, if it be meant that the foie power and ob¬ ject of the medical art are limited to the furthering of all morbid excitement, and to the removal of obftacles to the completion of the purpofes of that excitement ; i. e. to aflifting the efforts of nature, or guarding them from interruptions ; the affertion appears to be altoge¬ ther gratuitous, and nothing lefs than an abufe of lan¬ guage. In the firft place, it is founded on the affumption, that all difeafed adtion is falutary; which the effedts of numerous difeafes diredtly contradidt, and which has no better foundation than two other gratuitous affumptions, namely, the exiftence of a morbid ferment in the blood, and of an archeus, or rational foul, governing all the operations of the animal economy. But, fecondly, ad¬ mitting the falutary tendency of difeafed adtions, confi¬ dered as the efforts of nature, by what figns are we to interpret her intentions, or to difcover when (lie requires affiftance , and when reftraint ? On this point the greateft practical errors are likely to be committed, and have, in fart, been conftantly and extenfively committed, by thofe humoral pathologifts, who have prefumed upon their knowledge of the intentions of Nature. Another popular and general opinion arifing from the obfervance of this fucceftlon of difeafed adtions, and connedted likewife with the humoral pathology, is the dodtrine of metaftafis, or tranfpofition. It is found, that, on the difappearance of an eruption of the fkin, inflam¬ mation of fome of the vifcera often takes place; and again, that the cure of gout in the extremities fometimes produces very formidable eft'edts on the brain. Hence it was fuppofed, that there was an abfolute tranflation of fluid to the part fecondarily affedted. On this fubjedt, however, as we again find fome matter of an important nature in Mr. Pring, wefliall make another extradt. “ That certain difeafes are related with 'each other in the way of caufe and effedt, is a remark which is contem¬ porary with the earlieft records of medical obfervation. It is alfo a piece of information popular with all claffes, that the cure of one difeafe, whether fpontaneous or by art, is fometimes followed by the occurrence of another. Thus, it is common to expedl a favourable change of fome internal difeafe upon the occurrence of a cuta¬ neous eruption ; thus, alfo, it has fallen under the ob¬ fervation of the ignorant and unprofeflional, that a cuta¬ neous difeafe, cured by external applications, often pro¬ duces vifceral difeafe. The language of the vulgar in the firft of thefe cafes is, that the internal difeafe is coming out ; in the fecond, that the difeafe of the fkin is thrown in, or fettled upon the lungs for inftance. To all phyflcians the clafs of fadts here adverted to is well known ; they have been made the fubjedt of exprefs treatifes, and have been remarked upon in every age, and explained according to the prevailing pathology of the times. But the profeffors of medicine have of late been rather fceptical with refpedt to the affigned agency of the phenomena in queftion, though it is not improbable that their exception was taken rather againft the dodirine of humours, See. by which the phenomena were , explained, than againft the more modeft inferences which they might be allowed to furnifli. To all phyficians of the prefent day the clafs of fadts, defignated as thofe of re¬ lated difeafe, is well known : by fome, thefe facts are not fuffered to furnifli an inference of a relation, that is, they are confidered independent of each other; others admit the relation, and explain it in the language of the vul¬ gar ; others fay that one difeafe, inftead of falling or be¬ ing thrown upon another part, is converted into a difeafe 3 of PATHOLOGY. 91 of another part : fome phyficians admitting the clafs of fadts, and -admitting alfo the inference of a relation, be¬ lieve that the examples are very rare ; others are inclined to think them univerful ; aye, and to allow them only one tendency, although they might tend to fifty, or five hundred, different eft'e&s. It will appear from this ac¬ count that the exiftence of related difeafe has been long known, that the knowledge of it has become popular, and confequently there is no novelty in the ftatement of the fadt. If we would improve our knowledge with ret pedt to fuch difeafes, it muff be, not by ignorantly gene¬ ralizing a fingle limited clafs, but by a juft analyfis of its laws, by an inquiry into its nature, its frequency, and by an accurate difcrimination of its inftances. The firft fubdivifion which we have propofed of this clafs is that of related fecondary difeafe, tending to cure the pri¬ mary. “ Perhaps the moft unequivocal examples of related fecondary difeafe, tending to cure that which occurs in a primary feat, are thole of metaftafis. A perfon might have pneumonia clearly characterized by its fym'ptoms : the fymptoms of this local difeafe on a fudden lhall ceafe, and the fubjedt become immediately a fie fled with phre- nitis, which lhall be followed by death within eight-and- forty hours. Thefe occurrences may be confirmed after death by difleftion (quod vidimus teftamur). If we in¬ quire into the caufation in this example, there are thofe to whom the whole procefs is perfectly clear, who will reply, the inflammation left the lungs and went to the brain; was it then the fame inflammation? and, if fo, what was the objeft of its journey, or why did the inflamma¬ tion take it into its head to travel ? To analyze a little more curioufly: “ Inflammation exifts in the lungs: why does it ceafe in the lungs ? either from that progreffive caufation (which has been defcribed) taking place in the lungs, or from a progreffive caufation taking place elfewhere, by which a relation is opened between the feat of fuch pro- grefiive change and the properties engaged in the difeafe of the lungs, the end of which relation is, that difeafe is eftabliflied in a feco.ndary, and ceafes in the primary feat. The evidence in this cafe, derived from the order of fucceflion, is, that the difeafe in the lungs, being the antecedent, is alfo the caufe of the difeafe in the brain which fucceeds to it; in other words, the properties con- ftituting inflammation of the lungs leave this feat, and are transferred to the brain. But, if the pneumonia is the antecedent to the phrenitis, what is the antecedent to the metaftafis ? or why does a difeafe leave a feat in which it is eftabliflied ? The alternatives which muff form the anfwer to this queftion are fuggefted above: either a change takes place in the properties of the lungs, by which they no longer admit the ftate of inflammation, which is then affirmed by fome other vifcus, already in a predifpofed ftate to take up inflammation upon the cefla- tion of it in another feat; or elfe the brain (continuing our example) afl'umes a ftate which is fo related with the properties engaged in the inflammation of the lungs, as to produce a ceflation of the inflammatory condition in this feat. From this view it is obvious, that the fenfible fucceflion is inadequate to determine the caufation; for the brain may be the firft to afi'ume a change, by which it cures the difeafe in the lungs; or the difeafe may ceafe in the lungs, from caufation proceeding in this feat, and be aflumed by the brain, or any other feat which is predifpofed to this refult, under the relations which obtain upon the ceflation of a difeafe in a feat which it had hitherto occupied. “The alternatives here fuggefted muft obtain in every cafe in which the primary ceafes upon the occurrence of the fecondary difeafe, but they do net neceflarily obtain in all cafes of related difeafe : thus we fay dentition dif- orders the bowels ; this is a cafe of Ample fucceflion, which, by analogies before explained, we infer to be alfo one of caufation. If, upon the occurrence of dil- Vol. XIX. No. 1289. order of the bowels, the procefs of dentition w-ere fuf- pended, we fliould then have to determine whether the change preparatory to the metaftafis took place in the bowels or in the maxillary nerves. The progrefs of con- fumption might be fufpended upon the occurrence of pregnancy ; here confumption, as a related ftate, preceded pregnancy, yet we know, as the caule in this inftance is palpable, that the feat of that change which produced the mataftafis was the uterus, or fecondary related feat. Thus alfo the catamenia may be checked by an expofure to cold, which will produce rheumatifm; the change preparatory to, or caufative of, the metaftafis, is here alfo in the fecondary feat. From thefe and many fimilar examples, we may perhaps conclude very generally, that the primary difeafe in metaftafis does not produce the fecondary, but that the metaftafis itfelf is determined by a change which takes place in the fecondary feat. “ Related difeafe, according to our reduced divifiori, is of two kinds : ift, as when a primary difeafe ceafes upon the occurrence of a fecondary ; and, 2d, as wdien a fecondary merely fucceeds to a primary dileafe. The former inftances have been exprefled by the word metafld- fis, which implies that the difeafe leaves one feat and goes to another : this, however, is a conjefture without proof, for an inflammation of the eye may be cured by a fponta- neous diarrhoea ; if the identical properties of the pri¬ mary difeafe went to the leat of the fecondary, thefe properties, being thofe of inflammation, fliould produce inflammation of the bowels rather than a diarrhoea, which rarely occurs in inflammation of the bowels. If the identical difeafe of a primary is in metaftafis tranf- ferred to a fecondary feat, as the charaEter of the fecondary is commonly very different from that of the primary difeafe , it is necelfary to infer that the identical nature of the primary difeafe is liable to be modified by peculiarities which belong to the fecondary feat. “ This firft clafs of related difeafe, then, viz. that in which a primary ceafes upon theoccurrence of a fecondary difeafe, may be called JubJlitution of difeafe ; which merely exprefles the fadt that one difeafe has taken place, while another has ceafed : the word ‘ vicarious,’ which is familiar in medicine, exprefles the fame thing. The fe- cond clafs of related dileafe, viz. that in which the pri¬ mary does not ceafe upon the occurrence of the fecondary, may be called related extenfion of difeafe (the caufative relation being in both cafes aflumed upon the grounds before ftated). “ The examples of fubftituted difeafe are very nume¬ rous; and it is upon this experience of their frequency that the relation of caufe and eft'edt in fome or other of its modes comes to be inferred to fubfift very generally between them. We cannot, however, upon this point compel belief. Although the examples of fubftituted difeafe are very numerous, they are not fufficiently regu¬ lar to admit a claffification of thofe primary difeafes which are likely to be cured (to beg an expreffion) by the occurrence of fecondary ones. We can rarely, (owing to this irregularity) perhaps we can in no cafe, an¬ ticipate. the cure of a primary difeafe by a fecondary one; that is, we cannot pronounce that a certain fecondary difeafe will fucceed to the primary, and that the latter will then ceafe. We more frequently expedl the cef- Jation of a primary difeafe, when the fymptoms of a fe¬ condary one, of the tendency of which we have had ex¬ perience, do actually appear, than we anticipate a fubfti- tution of difeafe, while the exifting fymptoms occupy exclufively the primary feat. There is, however, an ex¬ ception to this remark, when the fame fecondary has been fubftituted for the fame primary dileafe, in one or more inftances.” Pring, ch. v. Difrnifling the confideration of thefe abftrufe and ob- feure fubjedts, we next proceed to confider the fymptoms of difeafes ; a fubjedl of the firft moment, and one w hich deferves the moft unremitting obfervation; for, though the caufe of the difeafe may be obfeure, and though its B b laws 92 PATHOLOGY. laws may beinfcrutable, painful fenfations and difordered fan&ions are. but too apparent. The great difficulty, therefore, which attends the ftudy of fymptomatology, is not to perceive fymptoms, but their congeries or catena¬ tions j and to obferve what are really the primary fymp¬ toms, and what are fympathelic, or fecondary: for it is on thefe obfervations that the diftinguiffiing of one dif- eafe from another depends. It was in this branch of pathology, in the (liagnojis, that Hippocrates and Syden¬ ham arrived at lo great a degree of perfection. Indeed, i-n the writings of the former phylician, we find fo excel¬ lent a fyftem of diagnofis, that we may even now turn to the ftudy of it with great advantage. We have enu¬ merated fome of the leading rules of Hippocrates’s fymptomatology; rules which enabled him to difcrimi- nate difeafes with great exaftnefs, ignorant as he was of the knowledge of phyfiology, ignorant even of all that regarded the pulfe except its molt violent actions. Of late, a return to thefe rules has been inculcated by one of the firll practical phyficians of the age we live in, Dr. Marlhall Hall : he has ffiown, that, though we had fo far deviated from the rules of Hippocrates as no longer to mention them, yet that all fcientific phyficians had made theminuteft obfervations on the phenomena of difeafe in their own minds, and had even fixed the identity of many complaints from the conviction thefe minute circum- ftances produced, without -however attempting to ana¬ lyze the appearances on which this conviction refted. To fupply this analyfis has been the objeCt of Dr. Hall ; and it mult be confeffed he has done it in the completed manner. To explain his meaning more clearly, wre ffiall quote a few lines from him. He obferves that there is in practical medicine a circumftance of the firft importance, the recognition of a difeafe. The general appearance of a patient, the peculiar modification, the particular com¬ bination, and mutual influence, of the fymptoms, give a general character to-the wliole difeafe, which is recog¬ nized and felt by the phyfician of experience and obfer- vation. “ Every praCtitioner of medicine is continually engaged in the bufinefs of diagnofis as the very ground¬ work of his profeffional duties ; and I fear the founded and mod enlightened are in the daily habit of aCting upon views that they would be at a lofs to defcribe, and have not time to analyze.” This paffage is quoted from the letter of a phyfician at once learned and experienced. It alludes diftinCtly to that general fource of diagnofis conftituted by the combination of all the circumdances of a difeafe. Dr. Hall adds, that he has had repeated opportunity of oblerving an eminent phyfician, on ap¬ proaching a patient, and that even during deep, exprefs his fentiment refpeCting the nature of the affection and condition of the patient ; the juftice of which time and the event have verified. This circumftance firft con¬ vinced him that there was fomething in the general af- peCt and appearance of difeafes, on which the experi¬ enced phyfician founds a diagnofis, and which it wmuld be of the greateft utility to analyze and defcribe. Diagnofis, or the ftudy of fymptoms, is founded on the obfervance of various phenomena ; the external appear¬ ance, the fenfa'tions, and the impaired funllions, of the pa¬ tient; not to fpeak of the more remote circumftances, which ftiould never be forgotten as the probable caufe of the difeafe ; the liability to certain difeafes from age, fex, temperament, &c. the effeft of medicines, &c. With regard, then, to the appearances of the patient, the firft and moll: obvious is the countenance ; the countenance is principally compofed and derives its expreffion from the aftion of the mulcles ; as the mufcles are capable of rapid contractions, are numeroufly fupplied with nerves, are the agents wdiich particularly manifeft the ftate of the mind, it is evidently a part in which morbid changes, either in the circulatory, mufcular, or nervous, fyftem, will become apparent : hence it indicates many impor¬ tant circumftances to the eye of the praCtitioner. Dr. Hall obferves that the following particulars are to be noticed with regard to the face. i. The colour, general or partial, z. Tumidity or ffirinking; general or par¬ tial. 3. Fulnefs or emaciation. 4.. ACtion or inaCtion of the mufcles; general or partial, continued or oc- cafional, irregular or fpafmodic. 5. The circulation. 6. Drynefs or moilture; general or partial. 7. The temperature. 8. Particular features. 9. General ex¬ preffion. The acute author juftly direCts our attention, how¬ ever, to the previous ftudy of the natural ftate of the countenance under various circumftances. He has di¬ rected us to confider the delicate and tumid ftate of complexion in the infant, the fmallnefs of its features, the abundance of cellular tiffue, the fmall development of the facial mufcles, their unmarked degree of expreffion, the larger and fuller llze of the eyes, the fmallnefs of the features generally. In youth, he ffiows that their ftates become gradually changed, and approach more nearly to the appearance of the adult countenance. He fays, however, that it is the nature and force of the cir¬ culation, and the condition of the cellular membrane, which impart the character to the countenance of youth. The circulation is ftrong and arterial ; the cel¬ lular membrane injeCted, firm, and elaftic. It is at this period and under thefe circumftances, that the ti¬ midity and ffirinking, obferved in the different forms and ftages of fever, and the changes from fulnefs to ema¬ ciation, in certain organic difeafes, are moft remarkable. The adult countenance is remarked to have a greater development of the mufcular fyftem, and the various expreffions of pain, anxiety, & c. are extremely well de¬ fined. The diforder of the circulatory fyftem, as indica¬ ted by rednefs, lividitv, or pallor, is likewife well defined. In old age, on the contrary, the leannefs, the flaccidity of the face, the want of colour, &c. are to be noticed. Sex further influences the countenance. In the female, the mufcular fyftem is lefs developed, the cellular more fo. In the ftates of conception, of the firft month of pregnancy, during the flow of the catamenia, a peculiar tumidity and enlargement of the features is obfervable. In advanced pregnancy, on the other hand, we often fee thinnefs, anxiety, and uneafinefs, vifible in different de¬ grees in the female vifage. The temperament falls next under confideration, as its principal charafteriftics are -manifefted in the face. Mental emotion, too, ffiould not be forgotten. Its in¬ fluence is fometimes exerted on the mufcular fyf¬ tem, fometimes on the circulation, and fometimes on particular features. Serioufnefs, gaiety, morofenefs, are characterized by their particular effeCts on the countenance, produced principally by means of the mufcular fyftem. Continued and deep thought caufes this fyftem to be afteiSted with an unufual degree of con- tradtion. Expectation and furprife induce a relaxation of the mufcles. Anger, fliame, fear, affeCt the circula¬ tion principally ; the firft moves the blood upwards, and fuffufes the forehead ; (haine dift'ufes a bluffi over the cheeks; fear renders the countenance pale and flirunk, and induces drynefs of the tongue. Joy and grief equal¬ ly occafion a flow of tears. Enthuiiafm animates the countenance as it does the bread ; defpondency depreffes the expreffion, as it makes the heart beat more feebly. External caufes often influence the countenance in a manner that it is neceflary to be apprifed of, in order to prevent an erroneous diagnofis. The immediate effeCt of bodily exertion and of external heat is to fuft'ufe the countenance; expofure to cold contrafts the features, and frequently induces an appearance of lividity. Repletion of the ftomach occafions an appearance of heavinefs and of propenfity to fleep, with a degree of ftift'ufion over the face. Want induces an oppofite eft’edt, an appear- ence of mental and bodily depreffion. Wine fuffufes the eyes and face, and, according to its quantity, en¬ livens or obliterates the expreffion. The next part which falls under our contemplation in diagnofis 93 PATHOLOGY. diagnofis is the general surface, in which the follow¬ ing circumftances are to be attended to; viz. i. The fur- face in general; as to colour, tumidity, or (hrinking of the integuments; oedema or anafarca, corpulency or emaciation, roughnefs or fmoothnefs of the Ikin, drynefs or moifture of the Ikin, and temperature, 2. The hands and feet in particular. 3. The elementary cutaneous aftedtions. And here again the circumftances of age, fex, and temperament, are to be noticed with the fame minute- nefs as in regard to the face. That part of the cutane¬ ous expanfion which envelopes the tongue has always been noticed as an important indication of the exiftence of dif- eafe. It Ihould be viewed with regard to, 1. Its moifture or drynefs, whether general or partial. 2. Its being with or without fur, clean or loaded, fwollen or indented. 3. The enlargement or difappearance of its papillae. 4. Itscolour. 5. How protruded. 6. The internal mouth in general, and the tafte and breath, fliould likewife be ex¬ amined. The attitude in difeafe is next to be confidered. This fubjedt comprifes a vie w of, 1. The pofition. 2. Changes of pofition. 3. The caution obferved in moving; or the oppofite ftate of writhing, or of jadtitation. 4. The ftate or eft'edts of mufcular adtion ; and the ftate of muf- cular power or debility. The healthy pofture of infants during fleep is various. The young infant ufually lies on its back, often with its hands and arms raifed above its head, or laid upon its cheft, or fpread open, and with its lower extremities drawn upwards. When it is laid on its fide, the upper and lower limbs are ftill placed in a ftate of complete flexion and relaxation. The pofture ufually remains un¬ changed, unlefs the infant be difturbed by external ob- jedts of fenfe, internal emotions, or difeafe. In the healthy and undifturbed fleep of adult perfons, the ufual pofture is that on one fide, the body being fre¬ quently inclined rather to the prone than to the fupine pofition. The head and Ihoulders are generally forne- what raifed, and, together with the thorax, bent gently forwards. The thighs and legs are in a ftate of eafy flex¬ ion. The pofition is apt to be changed from time to time, the perfon lying on one or other fide alternately. The attitude, motions, and manner, are confiderably influenced by the temperament, the degree of bodily ftrength, by the ftate of the mental operations, and by the paflions. In a ftate of great debility, whether from age or difeafe, the body uniformly falls into the fupine pofition ; and the recovery of the ufual pofition of the fide is always a fign of returning ftrength. Thefe, then, are the morbid appearances which are to be regarded in fymptomatology. As to the fecond head of morbid fymptoms, uneafy or painful fenfations, they are the moft frequent concomitants and figns of all dif- eafes. Few difeafes are free at leaft from uneafinefs : for, as there is a degree of pleafurable feeling belonging to the healthful adiion of all the organs of the body; fo, when thefe are interrupted and difturbed, the fick man fuffers pain, anxiety, and various difagreeable fenfations. Befides the various modifications of pain which we de- feribe by comparing them with the fenfations produced by different caufes, i'uch as a burning, (tinging, (tabbing, gnawing, pain ; a (hooting, throbbing, binding, pain, and fo forth ; itching, tingling, a fenfe of laflitude, of torpor, or numbnefs, of ltupor, of heat, of cold, of weight, naufea, giddinefs, faintnefs, ringing in the ears, and a multitude of uneafy feelings, indicate the varieties of difeafe. Sometimes the feverity of thefe feelings conftitutes the principal part of the difeafe ; and they agitate and diftrefs or terrify the patient fo much, that they become more dreadful than even the apprehenfion of death ; indeed, in many cafes, thefe painful fenfations are by no means deftitute of danger, from whatever eaufe they originate, as they may wear out the powers of life by their inceffant irritation. The third means of diagnofis is the confideration of impeded or deranged functions. This is a fubjedt of the greateft ufe in pradtical medicine ; for, as the knowledge of healthy function is the grand defideratum in all our inveftigations of the animal frame, fo a knowledge of their derangements may be confidered the principal part of the ftudy of difeafe. Thefe derangements often con- ftitute individual difeafe ; often, on the other hand, they are indicative of general or remote difeafe. It is for the latter purpofe that we now confider them; and it need hardly be remarked that the two previous methods of diagnofis which we have confidered, are, in a great mea- fure, fubfervient to this. In regard to derangement of the digejlive fundtion , independently of the examination of the tongue, breath, &c. before enumerated, we have to confider, firftly, the function of the pharynx and cefophagus, as it affedts deglutition. Secondly, Of the ftomach ; and herein of the appetite, third, hiccup, erudtation, naufea, vomiting, and the matters rejected. Thirdly, Of the bowels; as conftipation, diarrhoea, te- nefmus, involuntary (tools, flatulency, borborigma, dif- tention ; the ftate of the faeces; difeharges of mucus, blood, or pus. The fundlion of refpiration is next in order; and this fubjedl comprifes a view of, 1. The mode of refpiration. 2. The effedl of a full infpiration. 3. The kinds of cough and of expedtoration. 4. Sneezing, gaping, &c. 5. The ftate of the voice. 6. The phenomena mani- fefted by the ftethofeope, and the pulfation of the heart. In the circulatory J'yJlem, the moft important diagnoftic appearances are to be noticed with peculiar care. That alternate dilatation and contradtion of the arteries, which is called the pulfe, is the chief mean by which we are guided in afeertaining the nature of acute difeafes. The following divifions of this phenomena have been made. The flow pulfe, the quick pulfe, the Joft pulfe, the hard pulfe, the intermitting pulfe, and th e full pulfe. Many other varieties have been enumerated by different authors, by Galen, Bordeu, Nihel, Bellini, and Maflaria ; but they are entirely fanciful. Before we proceed to deferibe the varieties of the pulfe, it will be neceffary to fpeak of the many difcrepancies it exhibits in health. Thefe anomalies had not efcaped the penetrating eye of Celfus. He aptly obferves, “ Ve- nis enim maxime credimus, fallaciffimae rei ; quia ftepe iftae leniores celeriorefve funt, et astate, etfexu, et cor- poruin natura : faepe eas concitat et refolvit fol, et bal¬ neum, et exercitatio, et metus, et ira, et quilibet alius animi affedhis : adeo ut, cum primum medicus venit, folicitudo, asgri dubitantis, quomodo illi fe habere vide- atur, eas moveat. Ob quam caufam, periti medici eft, non protinus ut venit, apprebendere manu brachium ; fed primum refidere hilari vultu, percontarique, que- madmodum fe habeat : et ft quis ejus metus eft, eum probabili fermone lenire; turn deinde ejus corpori raa- num admovere. Quas venas autem confpedtus medici movet, quam facile mille res turbant !” Lib. iii. cap. 6. I11 our own time, Dr. Falconer has paid much attention to thefe circumftances ; and has fliown that, before we can derive any information from the pulfe, it will be ne¬ ceffary to obferve the varieties which exift in its natural ftandard, and alio the changes to which it is fubjedted by common caufes. The ftandard natural pulfe has been varioufly eftimated : perhaps theexadleft computation is that which reckons 73 beats in the fpace of a minute. The pulfe is generally, however, quicker than this in women, in perfons of fanguineous temperament, and in young children. The increafe of pulfe in women ap¬ peared to be in the ratio of one feventh more than in man. As to children, according to Dr. Heberden, “the pulfe of a healthy infant afleep on the day of its birth is be¬ tween 130 and 140 in one minute: and the mean rate for the firft month is 120 ; for during this time the artery often beats as frequently as it does the firft day, and I have never found it beat flower than 108. During the firft 94 .. P A T H O firft year, the limits may be fixed at 108 and iao. ' For the fecond year at 90 and 100. For the third year at 80 and 108. The fame will very nearly ferve for the fourth, fifth, and fixth, years. In the feventh year, the pulfatiohs will be fometimes fo few as y^, though generally more.” From the twelfth year, then, except that the pulfatioris are much more eafily quickened by illnefs or any other caufe, they differ but little from thofe of a healthy adult, the range of which Dr. Heberden ffates to be from a little below 60 to a little above 80 in a minute. From an ave¬ rage of five-and-twenty boys, obferved by Floyer, be¬ tween the ages of twelve and fixteen, thepulfe was about 83; in all of them above 80. With regard to the dimi¬ nution of pulfe which has been faid to be obfervable in the decline of life, Dr. Falconer is difpofed to believe, though not very confident in his opinion, “ that the pulfe in a healthy perfon becomes gradually flower from about forty-five years of age to about fixty, after which period it begins again to grow quicker, and to become, as fe- veral other circumftances in the fyftem do alfo, more refembling that of children. But to this,” he adds, there are undoubtedly many exceptions.” It has been generally fuppofed that ftature had a great influence on the pulfe; and Senac, from obfervations made on a hundred men in the royal guards, deduced the following eftimate of pulfes in proportion to ftature : namely, at two feet, pulfe 90; at four feet, pulfe 80; at five feet, pulfe 70 ; and at lix feet, pulfe 60. Dr. Bryan Robinfon has likewife made a computation, but it differs from Senac’s ; and, upon the whole, this point does not feem to be fatisfadlorily afcertained. Haller efpecially mentions, in oppofition to this opinion, that the Swifs people, who are generally tall, have quick pulfes ; and further inftances the fafr, that he was himfelf fix feet high, and that his own pulfe beat 78 in a minute. The pulfe is moreover influenced by the time of day. In the morning the pulfe is generally floweft, and be¬ comes accelerated towards evening. This is raoft re¬ markable in perfons in whom a high degree of nervous fenfibility is apparent. The principal caufes which ac¬ celerate the pulfe are food, exertion of every kind, (even fpeaking or Handing,) warmth, the paftions of hope, joy, and anger ; and fometimes, the reaction which fupervenes to fudden fhocks and impreffions on the nervous fyftem. On the other hand, the pulfe is depreffed by abftinence, fleep, fear, anxiety, and grief ; and by certain degrees of cold. But the operation of all thefe caufes is fubjedt to great variation, and is often countera&ed by the influence of oppofite agents. In feeling the pulfe, the degree of quicknefs is of courfe eafily determined by a ftop-watch ; the degree of force is eftimated by the refiftance which the artery op’pofes when compreffed by the finger. In order to afcertain this refiftance, the pulfe fliould be ftrongly comprefied by three of the fingers until no pulfation is experienced; after which, by gradually relaxing the fingers, we dial 1 afcertain its proportion with a tolerable accuracy. It is to be remarked, however, that the obefity of certain per¬ fons alters this circumftance; for not only is it more difficult to feel the degree of refiftance of the veffel when covered with a thick layer of fat, but fat perfons have likewife flower pulfes than lean ones. Another diftinc- tion of the pulfe is taken from its hardnefs : this term is ufed to imply a peculiar fudden vibration, like the fen- fation communicated by the fenfe cord or wire of a mu- iical inftrument. “ Some books,” Dr. Heberden remarks, “ fpeak of intermitting pulfes as dangerous figns, but I think without reafon ; for fuch trivial caufes will occa- fion them, that they are not worth regarding in any iilnefs, unlefs joined with other bad figns of more mo¬ ment. They are not uncommon in health, and are per¬ ceived by a peculiar feel at the heart by the perfons themfelves every time the pulfe intermits.” We have generally ■ onfidered thefe intermitting pulfes as of dyf- peptic origin, and havefeen theni removed, in fevers, by LOGY. a purge. Where the pulfe intermits, and is very unequal in its beats, and there is at the fame time palpitation of the heart, oppreflion of the breathing, lividity of coun¬ tenance, or other ferious fymptoms, then the intermiffion is probably one among the figns of fome affedion of the heart ; but in ordinary cafes, occurring with fymptoms of indigeftion, or flight feveriffinefs, it is perfedly void of danger. It is curious, indeed, that irregularities of the pulfe are fometimes habitual, and difappear only with good health. Dr. Heberden fays, “ many perfons will likewife have unequal pulfes without any other fign of ill health. I have met with two, who, in their bell health, always had pulfes very unequal, both in their ftrength and the lpaces between them; and, upon their growing ill, their pulfes conftantiy became regular; and it was a never-failing fign of their recovery, when their arteries began again to beat in their ufual ir¬ regular manner.” The writer of this article can add to thefe, an inftan.ee of an old lady of his acquaintance in whom the fame appearances as recorded by Dr. Heberden are very ftrikingly marked. The propriety of thefe divifions was formerly much queftioned, as implying an unneceflary and frivolous de¬ gree of minutenefs ; but it feems fcarcely worth while to make any remark on this fubjeft, as their neceffity is now generally admitted, and is eafily proved by the grand criterion of medical theory — its practice. It muft be ad¬ mitted, however, after all, that the pulfe, as Celfus fays, is “ fallaciffima res and it is only by regarding it in conjunction with the other modes of diagnofis that we are enabled to make practical ufe ofits various phenomena. The circulating fyftem prefents further points of con- fideration in regard to morbid changes in the blood. Thefe alterations are little underftood. It is probable that many exift of great importance, which are neverthe- lefs not cognizable to our fenfes. The moft obvious change in the blood is that which conftitutes what is called Jizy or inflammatory blood. It takes the former name from a tough buff-coloured coat which forms on its furface after coagulation, and which, according to Hewfon, confifts of albumen and a portion of fibrine ; and the latter, from its being peculiar for the moft part to inflammatory difeafes. Changes of lefs magnitude have been obferved in various other difeafes; as a peculiar blacknefs in the blood of fcorbutic patients, the want of red colour in, and the dilute quality of, the blood in fome ftages of dropfical and chlorotic aifeCtion, &c. But we forbear to enter into any further notice of this fubjeft at prefent. The reader may confult, for more particular information on this head, the works of Hewfon, Four- croy, and Thackrah. The ftate of the ezeernent fyjlem is principally examined by analyfis of the excreted lubftances ; as of the urine, fweat, uterine difeharge, &c. but in many inftances the inveftigation of thefe lubftances is very obfeure. The laft fyftem which remains to be noticed as afford¬ ing certain information in refpeft to diagnofis, is the nervous. The operation of the five fenfes, the elevated or depreffed ftate of the Ipirits, the ratiocinative and ima¬ ginative functions, afford notice of the degree of danger of fome maladies in. a moft certain manner; and hence deferve to be ftudied with diligence and attention. We now proceed to fpeak of Therapeutics, that branch of medicine to which all the other branches Hand in relation only as auxiliaries; auxiliaries, it muft be confeffed however, the attainment of which is ablolutely neceffary ere we can prafitife this branch in a philofophic manner. Unfortunately this truth has till lately been unknown. The long, the tedious, and (to untutored minds) the uninterefting, path of anatomical relearch, of obfer- vation, of experiment, and of cautious deduftion, fuits not the tafte of mankind in general. Hence they have attempted to cure their infirmities by fhorter and pleal'anter methods ; and hence, even now, the wonder¬ working fpecific claims unmerited attention; and the therapeutical 05 PATHOLOGY. therapeutical branch of medicine is purged of fewer of its ancient errors than any other of the pathological (ciences. The removal of difeafe may be eftefted by various agents. The firft, the mod obvious, and indeed the only ones of which the modus operandi is clearly underftood, are thofe which aft according to the common laws of matter. Thefe agents are few in number: they confift of the furgical operations ; of thofe fubftances which ope¬ rate chemically, as folvent^s of (tones in the bladder, clyfters diffolving fcybala, &c. The fecond are thofe which aft on the various parts of the animal fyftem by means of relation with the vital properties. But, as thefe properties are little underftood, it is very evident that we cannot trace with any accuracy their relation with medicinal fubftances. Hence much of the therapeutical branch of medicine refts on inferences of a very loofe and uncertain charafter. The aftion of moft of the articles of the materia may be fuppofed to affeft principally the contraftility of fibres or of veffels. Thofe which increafe the aftion of that power are called Jiimulants ; thofe which diminilh it ,/edatives; and medicines producing vifible effefts on the fenlibility of the nervous fyftem are called narcotics. The difficulty now to be overcome is to clafs the nu¬ merous fubftances of the materia mcdica under each of thefe heads ; a difficulty at prefent infurmountable ; for not only we do not know but the impaired ftate of fen¬ libility may arife from altered aftion of the contraftile forces, or that thofe forces may not be influenced origi¬ nally by the altered fenfibility ; but, further, we require a long feries of experiments to be inftituted ere we can admit into our claffification one half of the drugs con¬ tained in our Pharmacopoeia. For this reafon, deeming it more confonant with true philofophy to confefs our ig¬ norance than to perpetuate erroneous doftrines, it is our intention, when we come to that part of our article which more particularly relates to medicines and their dofes, to adopt the Ample order of the alphabet. And indeed, the pompous arrangements of the materia medica into dalles and orders, with other fubdivifions, are now de¬ rided by the faculty. Some medicines pofl’efs very diffe¬ rent powers, fo that their proper places are not eafily afeertained. They muft therefore be repeated under dif¬ ferent heads ; and it is evident how many repetitions fuch arrangements muft occafion; fince, when an article is properly placed, an increafed dofe of the fame would often carry it into another divifion, and the fame drug will have a different effeft in different cafes or ftates of difeafe. At p. 44, we have given the outline of Darwin’s arrangement, which is the moft concife ; but it does not fatisfy our minds. Kirby’s Tables contain 18 claffes, each, of courfe, divided into at lead three feftions, to in¬ clude animal, vegetable, and foffile, fubftances; and Dr. Cullen has 23 claffes, which are theie : Aftringents. Tonics. Emollients. Corrofives. Stimulants. Narcotics. Refrigerants. Antifpafmodics. Diluents. Attenuants. Infpiflants. Demulcents. Antacids. Antalkalines. Antifeptics. Errhines. Sialogogues. Expeftorants. Emetics. Cathartics. Diuretics. Diaphoretics. Menagogues. Of thofe who have copied Dr. Cullen’s arrangement with fome modification, there is perhaps none that de¬ fer ves more attention than the anonymous author of the “ Thefaurus Medicaminum,” and a “ Prafticai Synopfis of the Materia Alimentaria and Materia Medica.” This author diftributes the articles^of the materia medica into 12 claffes. 1. Evacuants, comprifing errhines, fiala- gogues, expeftorants, emetics, cathartics, diuretics, dia¬ phoretics, emmenagogues. 2. Emollients, comprifing diluents and emulcents. 3. Abforbents. 4. Refrige¬ rants. 5. Antifeptics. 6. Aftringents. 7. Tonics. 8. Vol. XIX. No. 1289. Stimulants. 9. Antifpafmodics. 10. Narcotics, n. Anthelmintics; and 12. Heteroclites ; this laft being formed to include thofe articles that could not properly be reduced under the former heads. Mr. Murray’s arrangement, which is very ingenious, is founded principally on the doftrine of univerful Jiimulus , and he thus explains the principles on which it is efta- blifhed. “Thofe ftimulants, which exert a general ac¬ tion on the fyftem, may firft be confidered. Of thefe there are two well-marked fubdivifions, thediffufible and the permanent ; the former correfponding to the ufual claffes of narcotics and antifpafmodics ; the latter, in¬ cluding likewife two claffes, tonics and aftringents. In thefe there is a gradual tranfition paffing into the one from the other, from the moft diffufible and lead durable lli- mulus, to the moft flow and permanent in its aftion. The next general divifion is that comprifing local ftimu¬ lants ; fuch are the claffes of emetics, cathartics, expec¬ torants, fialagogues, errhines, and epifpaftics. Thefe all occafion evacuation of one kind or other; and their effefts are in general to be aferibed, not to any operation exerted on the whole fyftem, but to changes of aftion induced in particular parts. After thefe, thofe few me¬ dicines may be confidered whole aftion is merely mecha¬ nical or chemical. To the former belong diluents, de¬ mulcents, and emollients. Anthelmintics may perhaps be referred with propriety to the fame divifion. To the latter, or thofe which aft chemically, belong antacids or abforbents, lithontriptics, efcharotics, and perhaps re¬ frigerants. Under thefe clafl’es may be comprehended all thofe fubftances capable of producing falutary changes in the human fyftem. Several claffes are indeed excluded which have fometimes been admitted ; but thefe have been rejefted, either as not being fufficiently precife or comprehenfive, or as being eftablilhed only on erroneous theory.” Murray’s Elements. Mr. Murray’s arrangement will beft be underftood from his own Table. A. General Stimulants. «. Diffufible. 5 Narcotics. ( Antilpalmodics. l>. Permanent. \ Tonics. ( Aftringents. B. Local Stimulants. C. Chemical Remedies. Emetics. Cathartics. Emmenagogues. Diuretics. Diaphoretics. Expeftorants. Sialagogues. Errhines. Epifpaftics. Refrigerants. Antacids. Lithontriptics. Efcharotics. D. Mechanical Remedies. Anthelmintics. Demulcents. Diluents. Emollients. Dr. Parr alters the arrangement of Dr. Cullen’s claffes, and increafes them to 26, as below: Emetics. Cathartics. Diaphoretics. Diuretics. Expeftorants. Errhines. Sialagogues. Emmenagogues. Stimulants. Refrigerants. Antifpafmodics. Tonics. Sedatives. Attenuants. Infpiflants. Alterants. Demulcents. Antacids. C c Antalkalines. Antifeptics. Emollients. Corrofives. Aftringents. Antidotes. Lithontriptics. Anthelmintics. Whilft 1 A I 96 PATHOLOGY. Whilft Dr. Cullen’s claffification has been thought too diffufe, and Dr. Darwin’s much too contraftedj and adapted merely to his own exceptionable fyftem of nofo- logy, Dr. Kirby, in his fmall traft, entitled “ Tables of the Materia Medica,” has inferted feventeen clafles, which are, upon the whole, judicioufly felefted ; and his ar¬ rangement has been adopted by moft of thofe modern ■writers who are of opinion that the materia medica are fo numerous as to require a methodus. The claflification is as follows ; and, as hinted before, every clafs is fub- divided, as far as poflible, into an animal, a vegetable, and a mineral, feftion. Clafs I. Emetics. — Emetics are fuch medicines as are calculated to excite vomiting, and thus difcharge the contents of the ftomach. II. Expectorants. — Thofe medicines are called ex¬ pectorants, that are employed to promote the excretion of pus or mucus from the windpipe and lungs. In ge¬ neral they are emetics given in fmaller doles, though there are feveral medicines, efpecially fome of the gum- refins, that are confidered to aft in this way, without any tendency to excite vomiting. III. Diaphoretics. — Diaphoretics are thofe remedies that are intended to promote, keep up, or reftore, the ex¬ cretion of perfpirable matter from the (kin ; and of thefe fome act but feebly, and only increafe the infenfibie per- fpiration, while others aft more powerfully, and, under favourable circumftances, excite fweating. IV. Diuretics. — Thefe are fuch medicines as promote or increafe the excretion of urine. V. Cathartics. — Cathartics are thofe medicines which promote or increafe the evacuation of excremen- titious matter, or of ferous fluids, from the bowels. VI. Emmenagogues. — Medicines which are fuppofed to aft on the womb, and to promote the difcharge of the menltrual flux ; but it is more than doubted if any drugs whatever have that peculiar aftion. VII. Errhines. — Thofe medicines are termed errhines that are employed to promote an increafed difcharge of mucus from the noftrils. VIII. Sialagogues. — Thefe are employed either to promote an increafed flow of faliva, or to produce fuch an aftion on the gums as (hail indicate their having been re¬ ceived in fufficient quantity into the circulation. Under the former diviiion are ranked feveral vegetable fubftan- ces 5 under the latter are included only mercury and its preparations. IX. Emollients. — The medicines commonly called emollients confift either of diluting liquors, formed of Ample water; or certain vegetable infufions ; or mucila¬ ginous and oily matters that have the mechanical pro¬ perty of defending the parts to which they are applied, from the aftion of acrimonious fubftances that pafs over them, or of foftening and relaxing the fkin and other external parts. The firft of thefe are commonly called diluents, the fecond demulcents, and the third limply emol¬ lients. X. Refrigerants. — Under this term are compre¬ hended thofe remedies which are employed with a view to diminifh the preternaturally increafed heat that takes place in the body during fevers and feveral inflammatory affeftions. XI. Astringents. — Aftringents are defined by Dr. Cullen to be fuch fubftances as when applied to the hu¬ man body produce a condenfation and contraftion of the foft folids, and thereby increafe their denlity and force of cohefion. If they are applied to longitudinal fibres, the contraftion is made in the length of thefe; but, if applied to circular fibres, the diameters of the veflels, or the cavi¬ ties which thefe furround, are diminilhed. XII. Tonics. — Tonics are thofe medicines w'hich are fuited to counteraft debility, or to give ftrength and ener¬ gy to the moving fibres. XIII. Stimulants. — Moll of the articles of the Ma¬ teria Medica might, in an extended fertfe, be called Jliniu- lants ; but this term is, by the general confent of phyfi- cians, reftriftively applied to thofe medicines which pof- fefs the power of fuftaining or increafing the vital ener¬ gies ; of raifing and invigorating the aftion of the heart and arteries ; and of reftoring to the mufcular fibre, when affefted with torpor, its loft: fenfibility and power of motion. XIV. Antispasmodics. — Thofe medicines which have been found by experience to put a flop to convulfive mo¬ tions, or fpafmodic contraftions of the mufcular fibres, are called antifpafmodics. Moft of them are ftimulants, fome narcotics, and fome are confidered as fpecific anti¬ fpafmodics. XV. Narcotics. — This term has been ufually applied to thofe remedies which are calculated to relieve pain and procure lleep. They have alfo been termed anodynes and hypnotics ; and moft of them were formerly ranked in the clafs of fedatives. XVI. Anthelmintics. — Thofe medicines which are employed with a view to expel worms from the bowels, are called anthelmintics. XVII. Absorbents. — Medicines which are taken in¬ wardly for drying-up or abforbing any acid or redundant humours in the ftomach or inteftines. They are likewife applied outwardly to ulcers or fores, with the fame in¬ tention. That each of thefe fyftems was framed by their authors in confonance with their peculiar and erroneous theo¬ ries is a fufficient reafon for their prefent difmiflal. Granting, however, that the effefts of the fubftances thus claflified were correftly detailed, it is very evident that moft of the clafles are eafily refolvable into the clafs of Jlimulants ; for fuppofing that any medicines can pro¬ duce expeftoration, that procefs can only be accompliftted by ftimulating the exhalent veflels of the bronchial ex- panfion ; and the fame remark is applicable to molt of the other clafles above mentioned. With refpeft to Simu¬ lants, the moft proper pathological divifion appears to be according to the particular ftruftures on which they exert their effefts. Of thefe the moft general are purga¬ tives, emetics, diuretics, and diaphoretics ; not to men¬ tion emmenagogues and a holt of others, the feparate and independent aftion of which does not appear to be well known. Purgatives. — Many errors have been committed in the adminiftration of this ufeful clafs of fubftances. The heterogeneous mixtures which have been made of them, and their indifcriminate application, fufficiently prove that the phyficians of the laft century did not properly underftand the ufe of them. To Dr. Hamilton and Mr. Abernethy we are indebted for pointing out the general and falutary effefts produced by the exhibition of purga¬ tives. Thofe a. thors have clearly fliown, that many nervous affeftions, and even chronic dileafes of the fe- creting and vafcular funftions, may be cured by thefe re¬ medies. Dr. Hamilton’s fuccefs in treating febrile and hyfteric difeafes has been truly great; and Mr. Aberne¬ thy has demonftrated their Angular utility in local dif¬ eafes, as obftinate ulcers, See. Accordingly the benefit of cathartics is now very generally eftirnated ; and we are perhaps in danger of falling into an error quite oppofite to our predeceffors, that of placing too much reliance on their ufe. Sufficient attention however has not been paid to the particular aftion of different cathartics. Praftitioners have been too much in the habit of preferibing them in- difcriminately, without fufficiently alluding to the effefts which each drug is capable of producing on the different parts and ftruftures of the alimentary canal. Mr. A. Carlifle firft diredted the attention of his profellional brethren to this point. “ Cathartics,” he obferves, “ ap¬ pear to operate in the following ways ; viz. either by ex¬ citing the periftaltic motion of the inteftines to an unu- fual degree, and thereby caufing them to protrude their contents more quickly through the alimentary paffage ; i or PATHOLOGY. or by increasing the fluidity of the alimentary mafs by fubftances which are obnoxious ; or to induce thefe two effe<5ts. The firft kind of cathartics probably aft upon the mufcular fibres of the inteftines, and the fecond kind feem to aft upon the vafcular parts of the inteftines. Some cathartics induce an unufual flow of bile into the inteftines 5 and in this refpeft they refemble, in their modus operandi, the natural ftimulus of the bowels, which is the bile. Other cathartics Simulate the exhUlent veflels of the inteftinal membranes, and thereby give an excefs of fluidity to the volume of their contents : or all thefe feveral modes of operation may be united by a fuit- able mixture of cathartic medicines. Again, fome ca¬ thartics aft efpecially upon the ftomach, and upon the upper portions of the inteftinal tube ; and others feem to ftimulate particularly the lower and larger inteftines. Some operate by emptying the bowels only, without di- minilhing the animal vigour ; whilft others fink the ftrength of the patient by emptying the Sanguineous fyf- tem at the time they hurry away the nutritious aliment.” With refpeftto the fubftances capable of producing the above-mentioned eftefts; the ingenious authoris inclined to think that rhubarb afts almoft exclufively on the fto¬ mach and on the large inteftines ; on the former organ efpecially when combined with ipecacuanha. Mercurial falts (of which thofe in moft common ufe are the blue pill and calomel) operate in two ways : by inducing Se¬ cretion of bile from the liver, and hence furnilhing the bowels with their natural ftimulus to action, or by their direft effeft on the coats of the larger inteftines induc¬ ing Secretion from the Surfaces of thofe organs. Mr. Carlifle fuppofes that the neutral falts aft by exciting watery discharges; but the aftion oft thefe fubftances is modified by the quantity of fluid in which they are taken, and by the previous condition of the alimentary canal; for they may be decompofed by the morbid Secretions. On this latter account Epfom falts are particularly re¬ commended by this author, becaufe, even if decompofed, their operation is ftill enfured by the purgative quality of their bafe. In regard to the modification produced on the aftion of thefe falts by their dilution, it is a cu¬ rious remark, that Small quantities of falts diflolved in large quantities of water aft with as much force, greater certainty, and lefs fubfequent exhauftion, than much larger quantities in Smaller menftrua. Caftor oil may be confidered as one of thofe rare purgatives which aft ge¬ nerally on the inteftinal canal ; perhaps by its vifcid ole¬ aginous part on the Superior portion of that canal, and by its acrimonious refin on the lower bowels. Its refinous portion is fuppofed by this author to be particularly ob¬ noxious to abforption ; and hence we may infer arifes the certainty of its operation. Jalap is one of thofe ca¬ thartics which Seems to ftimulate exclufively the peris¬ taltic aftion of the bowels, and is therefore of much ufe in evacuating them in acute difeafes. Scammony, gam¬ boge, and elaterium, aft moftly on the mufcular parts of the bowels, and perhaps the nervous; but thefe effefts, except in combination with other medicines, are very precarious. Aloes of Colocynth are generally fuppofed to aft on the lower parts of the inteftines ; but that effeft probably arifes rather from the infolution of thofe fub¬ ftances until they arrive So far, than from their Specific aftion on thofe parts. It Seems Scarcely neceffary to remark on the advanta¬ geous mode of ufing various forts of purgatives in con¬ junction, as that praftice has very generally obtained, and is very Successfully applied to all kinds of medici¬ nal fubftances. Cathartics may be adminiftered in the form of cJyJler ; and in many inftances this method has great advantage over the ordinary method. The French employ “ lave¬ ments" on almoft all occafions. They are chiefly ufeful in cafes in which the ftomach is unable to retain, or would be injured by, irritating medicines ; as in ga/irids, or inflammation of the ftomach, and in febrile complaints 97 attended with extreme debility, efpecially in the latter ftages ; fince by this mode the contents of the lower parts of the inteftines are Simply evacuated, without any fti¬ mulus to the Secreting veflels, and with little or no irri¬ tation of the fyftem at large. It is alfo to be obferved, that confiderably larger doles may be Safely employed in this way. It is of advantage to employ fome emollient fubftance, combined with the purgative, to defend the inteftine in fome meafure againft the acrimony of the me¬ dicine. Thus, if the eleftuary of Senna is ufed, it may be conveniently rubbed up with a little oil; and the whole will then mix uniformly with milk or any other liquid. When clyfters are employed as purgatives, it muft be remembered that they cannot pafs higher up than the valve of the colon, and consequently that they can only aft direftly upon the large inteftines. Therefore, they can Seldom entirely fupply the place of purgatives by the mouth, which pafs through and excite the whole inteftinal canal ; but they prove moft ufeful auxiliaries, particularly in thofe cafes of inteftinal diforder that are attended with much vomiting and irritability, where, befides emptying the lower bowels, they aft as topical fomentations, and very often induce eafe and deep when other methods fail. In Such cafes, therefore, they ftiould be in pretty large quantity, not very ftimulating, and as warm as the patient can bear them. As vermifuges, alfo, clyfters have a peculiar and local ufe, where the worms are lodged in the lower inteftines ; particularly as very highly ftimulating medicines are often required to dif- lodge -thefe troublefome animals, which, if given by the mouth, might produce a good deal of inconvenience and irritation. The reader will clearly perceive how insufficient thefe observations are, and how much the inveftigation of the remote modus operandi of various purges ftill remains a defideratum. The fubjeft, however, is confefledly fur- rounded with much difficulty ; yet a Series of experiments might probably be devifed to throw further light on this interefting fubjeft, which ftiould likewife extend to a much larger number of cathartics than thofe we have hi¬ therto confidered. Emetics, or thofe fubftances which operate a rejeftion of the contents of the ftomach, are of various kinds. Moft of the common poifons are emetics ; and many other fub¬ ftances, not deleterious in themfelves, do, when admi¬ niftered in exceffive quantities, produce ficknefs. Some difputes have been made public concerning the ac¬ tion of thefe fubftances ; fome phyfiologifts l'uppofing that they produced their effeft by ftimulating the fto¬ mach to contraftion, others that the abdominal and coftal mufcles were the agents concerned, and which produced vomiting, the ftomach performing no contrac¬ tion. Many experiments have been made on this point ; and the reiult renders it probable that both the above- mentioned powers are concerned in the aft of vomiting, and that the cefophageal part of the ftomach is firft afted on. The ufe of emetics in what may be termed a reftrained or limited degree is frequently attended with the moft powerful eftefts. The fenfation of naufea, that l'enfation which occurs previous to the aft of vomiting, is in the higheft degree debilitating: it reduces the aftion of the heart, and is attended with very general fecretion from the mucous expanfion of the nofe, eyes, fauces, air-cells, and ftomach. Hence dofes of emetics capable of produc¬ ing this effeft and no more are ufed in acute difeafes : for it is worthy of notice, that beyond the above-mentioned point (that of naufea), when vomiting Succeeds, the fyf¬ tem appears JlimutatecL, and the cerebral circulation in- creafed. So that to produce naufea, and to produce vo¬ miting, is a very different matter, and worthy of parti¬ cular attention. The aftion of the urinary fyftem is increafed by increaf- ing the natural quantity of fluids Swallowed, or by the ufe of Diuretics. The number of fubftances which have been praifed by different writers, as poffefl'edof diu¬ retic PATHOLOGY. i $8 retie powers, or capable of ftisnulating t lie aftion of the kidneys, is very great, efpecially from the vegetable world. Many of them, however, are very inefficacious ; and it is the common imperfection of the whole of this clafs to be very uncertain in their operation : fometimes the more feeble diuretics will fucceed, when the ftronger have failed ; and often, after every variety of kind and combination has been tried, the fecretion of urine remains unaltered. Digitalis, fquill, mercury, and cryftals of tartar, feparately or combined, are the mod efficacious of the clafs ; but the alkalies both fixed and volatile, fome of the neutral falts, the nitrous ether, the^terebinthates, See. are by no means ufelefs as auxiliaries. There is per¬ haps no clafs of medicines, in which a combination of two or more fubftances, poffeffing fimilar powers, is fo frequently important, as in that of the diuretics. Thus the ufe of potafs, joined with bitter vegetables, is recom¬ mended by fir John Pringle, as an efficacious medicine : and, as the alkaline fubftances may be often prevented, by purging, from reaching the kidneys, fo their diuretic effeft may be often more certainly fecured by giving an opiate at the fame time, according to the practice of Dr. Mead. A combination of the fquill, with digitalis, and fome of the lefs purgative preparations of mercury, as the common blue pill, is occafionally very aflive in its diuretic operation ; and, in children, or in old and feeble people, the union of the fpirit of nitrous ether, or of other diuretic fubftances, with the bark, or other vegetable to¬ nics, appears to be often very ferviceable. Diuretics, moreover, receive great additional power from perfeft fol'ution ; and it was remarked by Cullen, that the union of diluents with thefe fubftances was pro- duftive of the beft effefts. Diuretics are moll generally had recourfe to for the purpofe of determining fluids to the kidneys which were liable to be effufed ; and indeed they have been fuppofed to aft an important part in re¬ moving them when that procefs had occurred. If the latter luppofition be admitted, we muft fuppofe that a diuretic pofl'efies immediately the power of promoting abforption ; and of that we have no direft evidence. On the other hand, that diuretics can prevent the further accumulation of effufions is a faft of which we have llrong inference, and which is accordant with the inex¬ plicable law of derivation fo generally obferved. Diaphoretics are thofe fubftances which promote in- fenfible perfpiration, or fweat. Their modus operandi may be inferred to arife, either by direft application, or by nervous confent. If diaphoretics are affimilated, pafs into the round of the circulation, and are applied direftly to the cutaneous veflels, they may produce increaled contraftion, or the reverfe : or otherwife, the powerful fympathy obferved between moft parts of the mucous expanfions, and efpecially between the ftomach and (kin, authorife us to believe, that the contraftion or dilatation of the veflels of the flein may be produced by nervous excitement, firlt im prefled on the ftomach, thence propagated to the nervous general communication, and iaftly to their veflels; or, in other words, the effeft may be produced by fympathy. The older praflitioners took great pains with thefe medicines: the fudorific plan of treatment was the fruitful fource of miliary eruptions, and a variety of troublefoine complaints. The ufe of diaphoretics is at prefent much reftrifted, particularly thofe which increafe the general circulation. There are two means, by which perfpiration may be induced, and the aftion of fudorific medicines promoted ; namely, by application to the (kin, and ingefta. When the flein is not in a ftate unfavourable to perfpiration, the application of heat to the furface of the body, with¬ out any affiftance from powers internally applied, is fuffi- cient to produce fweating ; and the application of cold, i. e. the abftraftion of the heat, canalmoft certainly pre¬ vent the fame, though confiderable powers are employed within. Thus fweating may be obtained by the heat of the air, applied as in what is called the dry bath, or by increafing the heat of the furface by previous warm bathing, or by accumulating the warm effluvia of the body itfelf upon its furface. This laft may be done by covering up the body very clofely with fuch coverings as may both prevent the efcape of the warm effluvia ariling from them, and at the fame time prevent the accefs of external cold. But, farther to favour the diaphoretic aftion, a quantity of warm liquid may be taken into the ftomach, which not only excites the general circulation, but particularly, by confent of the veflels on the furface of the body with the ftomach, excites the aftion of thofe veflels which pour out fweat. The ufe of warm liquids alone, efpecially in the morning, while in bed, where there is a general difpofition to perfpiration, is in flight febrile cafes an ample fudorific. Thefe two means, of covering up the body clofely, and taking warm liquids into the ftomach, are what we call the fudorific regimen; which will often anfwer alone the purpofe of exciting diaphorefis ; is often neceflary to the operation of fudo¬ rific medicines ; and will always render their operation more complete and permanent. Cullen's Mat. Med. vol. ii. The combination of opium with fudorific medicines is valuable in two ways : the opium aids the operation of the fudorific, on the one hand ; and, on the other, the fudorific, by determining to the fkin, renders the ano¬ dyne effeft of the opium more certain and complete, and prevents fome of its unpleafant influence on the head : for opium, given when the flein is dry, or not accompa¬ nied by perfpiration in the courfe of its operation, is very apt to occafion reftleflnefs rather than fleep, and to pro¬ duce a flight approach to delirium, by its influence on the brain : hence the acknowledged value of the combi¬ nation which is univerfally known by the name of Dover's powder, as a fafe and aftive diaphoretic and anodyne ; it confifts of opium combined with the diaphoretics, ipe¬ cacuanha, and fulphate of potafs. Guaiacum too has been much praifed for its fudorific properties : Dr. Cullen confidered it to be one of the moft valuable of the ftimulant diaphoretics, becaufe it affords a matter which paffes more entirely to the ex¬ treme veflels, and feems to ftimulate the exhalents more in proportion than it does the heart and great arteries. By this means it is both a more fafe and more effeftual fudorific than thofe which ftimulate the latter almoft only : but acute rheumatilin, or rheumatic fever, as it is called, is almoft the only acute difeafe in which it can be recommended ; and it is a difeafe in which the fweat¬ ing is fpontaneoufly profufe, and bears ftimulants better than phlegmonous inflammations. Emmenagogues. — It has not been thought neceflary to treat particularly of emmenagogues, as they are moil of them general ftimulants, and are fo uncertain in their aftion that they can fcarcely be viewed as ftimulators of the uterus in particular. A few other minor divifions, are alfo commonly made; as Errhines, which aft on the mucous membrane of the nofe, &c. but thefe coniift of fo very fmall a num¬ ber of the pharmacopceal articles, that the mention of the fubftances themfelves would be lefs tedious than their claffification. There are fome articles in the materia medica which have been denominated general Jlimulants , from their effeft on the fyftem at large. They are little ufed at prefent in the praftice of phyfic, but were ftrongly re¬ commended by Brown, and confequently came into very general approbation during the time that author’s theories were triumphant. They obtained this diftinc- tion partly becaufe Brown was praftically and individu¬ ally acquainted with the healthy feelings they excited, but moftly becaufe their ufe naturally grew out of his theory of debility and excitement before noticed. Moft of thefe fubftances appear to influence the body by means of the nervous fyftem ; for the rapidity with which their aftion is elicited cannot allow us to fuppofe their PATH their abforption, and local application to the circulating powers. This remark will likewife apply to many of the Sedatives ; for, though thefe latter fubftances are for the moll part abforbed and carried into the circulation, and thus operate immediately on the contradfile powers of veffels, others exift of which the inftantaneous adtion allows of no explanation except the fuppofition that they adt on the nervous fyftem through the medium of the ftomach. It is obvious however, that, ftridtly fpeaking, all medicines adting on the nervous fyftem fliould be comprehended in another divifion ; but, as we before obferved, the modus operandi of the refpedlive articles in the materia medica is not fufficiently eftablifned to allow us to arrange them thus clofely according to their effedfs. We muft obferve, in this place, that many ftimulants attended with difcharges mayindiredlly produce fedative effedts by removing plethora ; as purgatives, diuretics, &c. The eftablifliment of the oppofite fadf, viz. that fome fubftances produce diredly fedative effedts, is a grand feature in the new Italian dodtrine, and in which that dodtrine is oppofed to the Brtinonian theory, which, as we have before fhown, fuppofed that all medicines were ftimulants, and only produced debility by promoting difcharges. This opinion is not to be difmifl'ed with quite fo little ceremony as many parts of Brown’s doc¬ trines ; for, though not admiftible to its full extent, it is rational to conjecture that many fubftances do produce inadlion of particular parts or organs by exceflive ftimulus on others, and thus that the clafs of diredt fedatives is very limited indeed. The moft powerful fedative agent that we ufe in me¬ dicine is Bleeding. This operation is however fcarcely capable of being arranged under any divifion ; for, in the firft place, if the fyftem is gorged with blood, there can be no doubt that fuch a ftate may arife as will preclude the rapid adtion of the heart; and in this cafe, by dimi- niftiing the quantity of blood to be moved, the motive power remaining the fame, the velocity will neceflarily be increafed. Thus, bleeding is a Jlimulant, on the other hand the rapidity of the heart’s adlion is in certain ftates reduced, or rendered flower, by bleeding. Thus, it is a fedative. Again, fyncopemay be induced by bleeding; and, as this is dependent on diminiftied circulation through the brain, the operation here holds relation with the nervous fenfibility. And further, the emptinefs of the fanguineous fyftem produces increafed adtion in the ubforptive powers. According, then, to the various ftates of difeafe, this operation produces different effedls, which are ftill further varied by the time and manner of its performance. With regard to the time, this has great influence on the cura¬ tive refults. Thus in inflammations of all kinds, it i3 necefl’ary to bleed in the early ftages, left the continuance of that difeafe fhould terminate in change of ftrudlure, or at lead in permanent dilatation of veffels. The manner of bleeding refpedts the abftradtion of blood from fmall or large orifices, by frequently-repeated and fmall, or by large and fudden, evacuations. Topical bleeding is ano¬ ther mode of abftradling blood which is ufefully employed in a great number of inflamed or excited parts, when previous exhauftion or other caufes preclude general bleeding. With regard to the mode of performing ve- nefeCtion, arteriotomy, acupunCture, & c. fee the article Surgery. The a£tion of the abforptive fyftem is increafed with a view to the removal of many folid depofitions, fluid fe- cretions, and extraneous bodies, &c. Like the circula¬ tory fyftem, it may have its contradlile phenomena in¬ creafed or diminiflied. The firft indication is attempted by mechanical preflure, and by certain medicines called ftimulants ; and it feems further increafed in direft pro¬ portion to the exhaufted ftate of the heart and arteries. The fecond change, or the diminution of the aCHvity of s^fpEbents, is not found to attend with certainty the ex hibition of particular drugs ; but it is produced by various Vol. XIX. No. 1290. O L O G Y. v 09 morbid alterations, by heat, by the defeft of mechanical preflure, and by the reduction of nervous fenfibility. To return however to the ufe of ftimulants ; mechanical prejfure is an agent which exerts great and general in¬ fluence over the abforbent fyftem. In their courfe through the extremities of the body, the abforbents are compreffed by the diftenfion of the arteries, and during the contraction of mufcles ; within the cavities of the abdomen and thorax, they are fubjeCted to the preflure of the ingefta, of the diftended air-cells of the lungs, the movements of the diaphragm, and of the refpiratory and abdominal mufcles. Atmofpherical preflure, as well as the weight of clothes, &c. is likewife to be taken into eftimation. It is obvious that, as abforbents are furnifhed with valves which prevent the return of fluids towards their open mouths, prejfure muft accelerate the flow of their contents towards their venous terminations, It muft here be remarked, that the effeCt of long-con¬ tinued preflure is probably two-fold; operating on the one hand to increafe abforption, on the other to prevent depofition. Medicines which increafe abforption operate for the moft part by increafing contraction. But they may further, in fome ipftances, render folid depofi¬ tions lefs difficult of abforption, by producing folu- tion of their conftituent parts. That an empty ftate of the fanguineous fyftem generally renders abforption more aCtive, is a faCt which we fliould be inclined to ad¬ mit a priori ; and it has received full confirmation from the well-known experiments of Majendie. It explains how purgatives, diuretics, &c. to which the older phyfi- cians attributed abforptive powers, may really bring on abforption, by caufing depletion ; and it further renders plain the circumftance, that a great number of medicines do not manifeft their falutary operation except in ex¬ haufted depleted patients. In our therapeutical indications, one of the moft im¬ portant is the imitation of' nature in the production of oppofite difeafes. That difeafe in one part or ftruCture of the body often ceafes on its production in another, is, as we have before ftiown, a general law in pathology, fub- jeCt however to many exceptions. It is in expectation of producing this falutary change that we ufe many of the moft powerful ftimulants. Thus blifters, muftard-cata- plafms, embrocations, moxa, &c. are employed with the intention of converting difeafes, i. e. of inducing aCtion in a part not effential to life, for the purpofeof removing it from one in which its direefteCts are known and appa¬ rent. It is to be obferved, however, that contra-irrita¬ tion is a mean which can only be reforted to with ad¬ vantage in certain degrees of inflammation ; for it is known that, in inflammations of the higheft magnitude, blifters, when applied before bleeding and evacuants have been premifed, increafe general irritation without alle¬ viating topical difturbance ; and this holds good in re¬ gard to moft other fubftances of the fame clals. As appendices to the ufual and common remedies, we have to mention medical eleCfricity, and the inhalation of gazeous fluids. Each of them has received an ephe¬ meral and exceflive degree of praife ; and hence, like many of the furprifing remedies perpetually arifing, have fallen into undeferved contempt. The cure of the moft violent and inveterate difeafes has been afcribed to eledricity, All that now remains certain with regard to it is, that it is a powerful ftimu- lant, and one which is the more ftrongly recommended, becaufe it can be applied to a variety of parts, when the common methods of ftimulation cannot be employed. The mildeft modes of ufing electricity are thofe rnoli in vogue at prefent, as its violent application is reprobated by the belt practical writers. Its ufe in fufpended ani¬ mation, in chronic glandular enlargements, in atony of the organs of generation, are well known. Animal electricity, or Gaivanifm, is in fome refpeCts fimilar to common eleCtricitt n its effects, and in others different ; but, in a medical view, it has not anfwered the D d expectations 100 PATHOLOGY. expectations which at firft were formed of its aCtion. All thofe animals which polfefs excitability are affeCted by Galvanifm as they would he affeCted by any other violent ftimulus; and, if the excitable part be at all mufcular, the fibres are vigoroufly contracted. This caufes, in a living and confcious animal, a fenfation not unlike an eleCtric fhock. The (hock is more like that of common electri¬ city, as the plates of the battery are fmaller and more numerous. When the plates are of very large furface, a fort of vibratory motion is felt through1 the part, at¬ tended with a fenfation of heat ; and this, in a powerful battery, is felt fo longas the connection is kept up. The bell mode of taking the fliock is firft to moiften the hands, or the part where the effeCt is to be applied ; grafp in each hand a 'piece of metal, fuch as two fpoons, and touch each end of the battery with the other ends of the fpoons at the fame time. If it is intended to be applied to any other part, let two plates, of about two inches in diame¬ ter, be each attached to the wires coming from the bat¬ tery, and let the plates be applied to fome two parts : if the effeCt be too fevere, let fome inferior conductor be placed between the plate and the fkin. Sir H. Davy found, that, when an animal fubftance was placed in the circuit of a galvanic battery, the different compounds contained in it were decompofed. This was more Spe¬ cially the cafe with the faline bodies contained in the animal fluids; the acids of the falts were found on the pofitive fide of the battery, and the bafes of the falts on the negative. Should it be afcertained that any redun¬ dancy of faline matter is the caufe of difeafe, Galvanifm might be employed with great fuccefs in feparating thofe bodies from the fyftem. See the article Electricity, vol. vi. p. 409, 445, & feq. Pneumatic medicine, or the ufe of gafes in the cure of various internal complaints, was very falhionable at the time chemiftry formed one of the moll ardent purfuits of the French nation, and when they attempted to explain the vital properties according to the laws of oxygen, &c. And in this country, Beddoes, Rollo, Cruikfhank, and others, made many interefting experiments and trials on this fubjeCt. Of late its ufe has declined. See Oxygen, vol. xviii. p. 1 67. The diverfified experiments of Sir H. Davy on the refpiration of nitrous oxyde and fome other gafes, fo in- tereftingly defcribed in his fcientific refearches in 1800, in a great meafure diflipated the general apprehenfions of fatality refulting from the inhalation of compound gafes, and fatisfaClorily demonftrated that many of the aerial fluids, before confidered as deftruCtive to vitality, might be breathed with perfeCt fafety. The following cafe, (howing the beneficial effeCts of oxygen gas in reftoring fufpended animation, occurred in the year 1814, in the laboratory of the Dublin So¬ ciety, and excited confiderable intereft. It was commu¬ nicated by Samuel Whitter, efq. who made the experi¬ ment on himfelf. He introduces the account by obferv- ing that, when a mixture of carbonate of lime and zinc, or iron-filings, is expofed to an intenfe heat, the peculiar gafeous fubftance named carbonic oxyde is difengaged, which has been ftated to bear the fame relation to car¬ bonic acid that nitrous gas does to nitric acid. But agreeably to the ftriking obfervations of Mr. Higgins, profeflor of chemiftry to the Dublin Society, in his work recently puhliflied, (wherein his claim to the difcovery of the atomic fyftem is unequivocally eftablilhed,) it would appear that, in the combination of oxygen with different gafes, it is the atom of oxygen only that is found multiplied, as is beautifully exemplified in all the metal¬ lic oxydes, acids, and gafes. An apparent anomaly has been noticed with relpeCt to nitrous oxyde, which the experiments of Mr. Higgins on the compofition of nitrous gas tend to obviate, and fanCtion a comparifon of the proportions of carbon and oxygen in carbonic oxyde with thofe of azote and oxygen in nitrous oxyde, rather than the atomic coincidence of carbonic oxyde and nitrous gas. Carbonic oxyde was difcovered and defcribed by Mr. Cruikfhank in 1801 ; it is highly combuftible, burn¬ ing with a fine blue flame, but it is utterly incapable of fupporting animal life. “ Defirous of witnefling the progreflive effeCts of car¬ bonic oxyde when freely refpired, with a view to compa¬ rative analogy in reference to nitrous oxyde, I was tempted a few days ago to inhale a portion of it as copi- oufly as poflible. The confequence had very nearly proved fatal to me. A confiderable quantity of the gas having been carefully prepared by Mr. S. Wharmby, the very ingenious and able afliftant to Mr. Profeflor Higgins, a feries of experiments on its refpiration were propofed. Mr. Wharmby firft noticed fome points of refetnblance it bore to the nitrous oxyde, particularly the Angularly fweetifh tafte ; and, having made two or three infpira- tions, was feized with a degree of convulfive tremor and giddinefs that nearly overpowered fenfibility. Thefe violent effeCts were but tranfient, though confiderable languor, head-ache, and debility, remained for many hours afterwards. Anxious to purfue the experiment ftill further, I next made three or four hearty infpirations of the gas, having firft exhaufted my lungs of common air as completely as poflible. The effects were an incon¬ ceivably f'udden deprivation of fenfe and volition. I fell fupine and motionlefs on the floor, and continued in a ftate of total infenfibility for nearly half an hour, appa¬ rently lifelefs, pulfstion being nearly extinCt. Several medical gentlemen being prelent, various means were employed for my reftoration, without fuccefs ; when the introduction of oxygen gas by compreflion into the lungs was, fuggefted, the effects of which may be fairly con- trafted with thofe of the carbonic oxyde. A very rapid return of animation enfued, though accompanied by convulfive agitations, exceflive headache, and quick ir¬ regular pulfation, and, for fome time after mental reco¬ very, total blindnefs, extreme licknefs, and vertigo, with alternations of heat and (hivering cold, were painfully experienced. Thefe unfavourable fpafms were fucceeded by an unconquerable propenfity to fleep, which, as might be expefted, was broken and feverilh. An emetic of tartarized antimony finally removed thefe alarming fymp- toms, and the only unpleafant effeCts felt on the en- fuing day were thofe occafioned by the fall. “I very much regret that the confufion arifing from the idea of my death, fo dilturbed the arrangement, that no accurate determination could afterwards be made, either of the quantity of gas refpired, or the change it underwent in the procefs ; and the experiment is rather too hazardous for repetition. Neverthelefs, the extra¬ ordinary efficacy of oxygen gas in cafes of fufpended ani¬ mation produced by carbonic acid, choke-damps, and other fuffocating gafes, is fairly deducible, and I conceive cannot be too forcibly recommended to the faculty, in fuch inftances. I therefore fincerely hope that the refults of this experiment may be of practical utility in thofe cafes, which are fo frequently occurring, and are often fo awfully fatal ; it being the decided opinion of the pro- feflional gentlemen prefent on this occafion, that the free ufe of the oxygen gas was folely inftrumental in reftoring me to life. “ Mr. Higgins himfelf had nearly once fallen a viCtim to a fimilar experiment with fulphuretted hydrogen, the effeCts of which, after recovering from a death-like infen¬ fibility, were painful and oppreflive for many days.” This very ihort (ketch may appear fcarcely a fufficienc account of General Pathology and Therapeutics. The pathological reader will be immediately ftruck with the omiflion of all notice of Spafm, of Inflammation and its confequences, &c. But we have rather deemed it prudent to invelligate thefe fubjeCts under their feparate heads, and have merely inferted thefe obfervations as being of too general a character to be reduced under any of our divifions. We therefore at once proceed to the CLASSIFY 101 PATHOLOGY. CLASSIFICATION of DISEASES, According to the fyftem of Dr. Mason Good. Clafs I. C celiac a, Difeafes of the Digeftive Funftion. Order r. Entericu. Affecting the alimentary canal. 2. Splanchnica. Affefting the collatitious vifcera. Clafs II. Pneumatica. Difeafes of the Refpiratory Funftion. Order i. Phonica. Affefting the vocal avenues. 2. Pneumonica. Affe&ng the lungs, their mem¬ branes, or motive power. Clafs III. H/ematica. Difeafes of the Sanguineous Funftion. Order t. Pyrettica. Fevers. a. Phlogotica. Inflammations. 3. Exanthematica. Eruptive fevers. 4. Dyjlhetica, Cachexies. Clafs IV. Neurotica. Difeafes of the Nervous Function. Order 1. Phrenica. Affefting the intelleft. 2. JEJihetica. Affefting the fenfation. 3. Cinetica. Affefting the mufcles. 4. Syjlatica. Affefting feveral or all the fenfo- rial powers fimultaneoufly. Clafs V. Genetica. Difeafes of the Sexual Funftion. Order 1. Cenotica. Affecting the fluids. 2. Orgujlica. Affecting the orgafm. 3. Curpotica. Affefting the impregnation. Clafs VI. Eccritica. Difeafes of the Excernent Func¬ tion. Order 1. Mefotica. Affedting the parenchyma. 2. Cutotica. Affedting internal furfaces. 3. Acrotica. Affedting the external furface. Clafs VII. Tychica. Fortuitous Lefions or Deformities. Order 1. Apalotica. Affedting the foft parts. 2. Stereotica. Affedting the hard parts. 3. Morphica. Monftroflties of birth. Class I. C CELIAC A, [from the Gr. Koihict, the belly.] Diseases of the Digestive Organs. There is no clafs of difeafes which more imperioufly demands the earned and attentive conlideration of the patliologift than this ; and certainly there is no clafs of difeafes which has of late received more attention from the medical world. We have before remarked on the connexion which the alimentary canal holds with the reft of the fyftem ; and on the media through which this connexion is fupported. We have fliown, that, if the fenforial powers be difturbed, the nervous productions which expand on the mucous membrane of the alimen¬ tary canal will have their office altered orfufpended, and deficient fecretion will be the refult 1 that, on the other hand, every part of the mufcular and nervous fyftems may be. affefted by the difordered ftate of the alimentary canal, fince the impreffions of the latter, conveyed to the brain, may affeft, through it, all other parts. This reciprocal dependence and relation, then, we are quite willing to admit ; but we have here to pauie, and to con- fider a doftrine which is founded on this relation, but which we are unwilling to admit. It is the doftrine, that the primary caufe of difeafe refts immediately in the ftomach and bowels. Now it is very obvious, that, in tracing the origin of difeafes, the order of fucceffion obferved by its fymptoms is the only guide which we can adopt ; and it requires little experience to prove that the fucceffion of /ymptoms affords in many difeafes direct contradiction to the doftrine above mentioned. For inftance, the effect of ftudious and fedentary habits on the human frame, by inducing long and exceffive ac¬ tion of the brain, is to exhauft fenfibility ; hence the due tranfmiflion of nervous power will be interrupted, and the fecernent fyltem will be deranged in various ways. It is true, the ftomach and bowels are generally the parts in which this derangement is principally made manifeft ; but this does not occur invariably. The fecretion from many glands is fometimes difturbed, while the gaftric and enteric fluids prefent no fenfible change. Again ; a blow on the head, though it frequently produces vomit¬ ing, yet that effeft is not uniform. And again ; in the efteCt of temperature, whether diminiffied or increafed, we are able to trace the order of fucceffion through the circulating to the nervous fyftem, without meeting with any implication of the digeftive function in dilorder ; and fo on. That the alimentary canal is a medium through which morbid materia and impreffions are con¬ veyed to the reft of the fyftem, we have before ftated ; yet fuch conveyance may not derange thefe organs, but may produce fecondary effects on other ftruftures ; effects which' may require remedies of a nature quite different from thofe calculated to relieve ftomachic or inteftinal derangements. Strong objections too are in force again ft another part of the lame doftrine, viz. that of conli- dering the ftomach as a centre of fympathy ; that is to fay, when thofe terms are ufed to exprefs a peculiar property of the ftomach, a property different from what is obfer- vable in all mucous expanfions. For aflu redly the lize or intenfity of power in the nerves, will fufficiently ac¬ count for the ready and general fympathy obferved with regard to that organ, and other parts of the body, with¬ out reforting to this gratuitous hypothefis. An argument is advanced in fupport of the origin of difeafe in. the ftomach, which we are inclined to regard with greater refpeft than any of the reft 5 namely, that the cure of many local and conftitutional complaints is effeCled by means which procure copious fecretion from the alimentary canal. We may obferve, however, that, while we allow the faft, the hypothefis which is founded on it need not be admitted. The alimentary canal may be confidered (in a greater or left degree in its various parts) as the emunStory of the fanguineous fyftem. Thus even the bile, befides its ufe in the reparation of chyle, is carried downwards in large quantities with the feces. The bowels, too, pour large quantities of fluids, which vary in their fmell, colour, and confiftence; and, to a certain degree, without the health being affeCted. Hence fecretion from thefe parts may aft in various ways 5 either by removing certain Hates of plethora, or by eliciting from the blood noxious particles. In this way, emetics thrown into the blood, are feparated from that fluid by the digefting fecretions, and produce vomiting. We are aware that this feems to approach, in fome degree, to the humoral pathology ; but it is now become admitted, that our pathological theorifts have perhaps too clofely dis¬ carded the explanation of difeafe which this doftrine af¬ forded. The proximate caufe mull, indeed, be looked for in the aftion of the folids ; but the medium through which difeafe is propagated is, undoubtedly, very often the blood. The violent effeft produced by the injeftion of a fmall quantity of air, or of other kinds of fluids, feems very direft confirmation of this opinion. We muft further remark, that the promulgators of thefe doftrines have overlooked the manner in which the derangements of the collatitious vifcera alter the ftate of the ftomach and bowels ; an effeft which takes place ei¬ ther by means of the application of morbid fecretion, or by continuity of difeafed aftion. With regard to the remote caufes of difeafe in the digeftive organs, the fol¬ lowing are ftated by Dr. Nicholls in his Elements of Pa¬ thology. “ The procefs of digeftion may be imperfeftly performed, owing to a variety of caufes; among which we may reckon, — Food of an improper quality, or in improper quantities ; imperfeft performance of the pro¬ cefs of maftication, in which cafe the food will not be fufficiently mingled with faliva, nor will it be fufficiently broken down and divided ; diminilhed fecretion of faliva, ordifcharge of that fluid from the mouth; increafed fe¬ cretion of faliva; difeafed ftates of the fluids which flow into PATHOLOGY. 102 into the fauces ; an altered ftate of the gaftric or of the pancreatic juices ; the prefence of an increafed or dimi- niftied quantity of thefe fluids ; an altered ftate of the bile; an infuflicient quantity of that fluid, whether ari- fing from diminifhed fecretion, or from fome obftrudtion to its influx into the duodenum ; the prefence of too great a quantity of bile ; the flow of too great a quantity of that fluid into the ftomach ; dileafed condition of the ftomach, whether confiding of Ample plethora, of inflam¬ mation, diminifhed capacity, inordinate diftenfion, thick¬ ening of its coats, partial rupture, ulceration, or dif- placement; difordered conditions of the cardiac or py¬ loric orifices ; obftrudied ftates of the inteftines ; hurried adlion of the bowels ; increafed fecretion of enteric juice ; diminifhed or depraved fecretion of that fluid ; col¬ lections of fteces; worms ; diminifhed fenfibility of the nerves of the ftomach, whence may enfue diminifhed fe¬ cretion of gaftric juice, and diminifhed adlion of the mufcular fibres of that cavity; an interruption of the communication between the cerebral and the anti-cere¬ bral extremities of thofe nerves; increafed fenfibility of the nerves of the ftomach, whence may enfue, increafed fecretion of gaftric fluid, pain referred to the ftomach, and the production of vomiting; altered ftates of the cranial and fpinal brain; deficiency of nervous power ; longabfence offleep; an increafe ora diminution of tem¬ perature, generally or locally ; powerful fenfations ; paf- fions, efpecially thofe of the deprefling kind; powerful exertion of the faculties, &c. &c. The firft caufe of difeafe, then, which we have to treat of, is the food. On this fubjeCt we propofe to fpeak fomewhat fully, becaufe it regards one of the princi¬ pal agents in therapeutics. The difeafed aCtions of the alimentary canal, of the collatitious vifcera, and laltly of the ftate of the nervous, power, will conllitute the next fubjedls of difcuflion. That the natural food of man is equally theprodudl of the animal and vegetable kingdom; that his digeftive powers accommodate themfelves, in a certain degree, to various kinds of fuftenance; that, ceteris paribus, vege¬ tables and water are capable of nouriftiing men of the rnoft powerful mufcular and ienforial developments ; and that the oppofite practice is attended with equally good effedls ; are truths fo generally admitted and firmly founded on the hiftorical records of every country, that they need form no part ofourprefent difcuflion. On the other hand, that the partially-refined and half-civilized ftate in which we now live, our frequent meals, their quantity difproportioned to our exercife, and the various combinations which the culinary art affords us, may be faid fully to counteract the ufeful and accommodating conftitution with which we are endowed, are remarks fo trite and familiar, that nothing but their importance, ancl the want of attention paid to them, excufes our re¬ petition of them. The diet of man requires a certain adaptation to the varieties of climate ; and here injlind , (or, as fome call it, nature,) untutored by education and refinement, feems the bell guide ; for we find moft fa- vages preferring in hot climates the vegetable fufte¬ nance, in colder regions animal food: and this me¬ thod of life experience proves to be moft conducive to longevity and ftrength. Not that we are very favourable to the mode of life called natural, being fully perfuaded that man’s natural ftate is that of the higheft civilization, fince to that he is continually tending; and hence we ftiould not have ufed this faft as an argument unlefs it had been fupported by our own experience. The fubjeCt of diet, in reference to our own climate, and in cafes of difeafe, has occupied very general atten¬ tion ; but the difficulty with which this fubjedt is at¬ tended, precludes us from prefenting our readers with any •philofophical view of it ; for moft writers have been occu¬ pied withdetailingthegoodorbad effedlsof particular fub- ftances, founded, it is to be feared, in too many inftances, on partial views or individual feelings. Thus we are continually hearing, even from medical men, that fuch a thing is eafy of digeftion, and another difficult, and fo on; while our indiferiminate application of thefe rules foon teaches their fallacy : it foon fhows that what agrees with one perfon produces violent effedls on another, and that different ftates of diforder in the ftomach require regimen of very oppofite powers. In the natural and healthy ftate of the body, we mull regard in fome meafure the Hippocratic advice; not to carry our dietetic arrangements to a too great degree of refinement, becaufe any occafional irregularity will produce the more unpleafant effedls ; but at any rate the ftate of health is bell confulted by partaking of few articles at a meal. The proportion of exercife, too, be¬ comes a matter of conlideration ; but inftindl points out the true path ; for, as lefs exercife is taken, lefs appetite is experienced. The habit of meeting our friends at meals, the variety of provifions which kindnefs and hof- pitality prefent to and urge on us, are perhaps the moll frequent caufes why thele inftindlive calls are fo feldom attended to. But, though to thofe who take frequent exercife, this relaxation and enjoyment is productive of fcarcely any inconvenience, yet it is feverely felt by the fedentary and the ftudious ; and hence to the latter are rules and regulations more generally addreffed. It has been held of late years that drinking at meals is an unneceffary, and indeed improper, cuftom. This opi¬ nion receives fupport from obferving the habits of ani¬ mals, few of which drink while digeftion is going on in the ftomach. In Greece, this cuftom of dry feeding is faid to prevail ; and Xenophon fays, that the ancients did not drink till the repaft was finilhed. We have not fuffi- cient proofs to enable us to engage in proving or difpro- ving this dogma; but we may obferve, that its applica¬ tion fhould of courfe be fomewhat regulated by habit and inclination, and by the nature of the food and the ftate of the atmofphere. In the Didlionnaire des Sciences Medicales, the fentiments of Halle and Nyften on this fubjedl are thus expreffed : “ La quantite de boiffon k prendre pendant le repas doit etre en proportion d’autant plus grande ou moindre, que les alimens eux-memes font plus fees ou plus humides ; qu’ils fe laiffent plus ou moins aifement penetrer par les liquides falivaires et gaf- triques ; qu’ils forment, par leur vifeofite, une maffe plus ou moins tenace ; qu’ils ont plus ou moins la pro- priete de diftendre l’eftomac et d’y fejourner uncertain temps. Les boiffons doivent aufli etre prifes en quantite plus ou moins grande, fuivant les conftitutions indivi- duelles qui, en raifon de leur degre de fechereffe ou d’hu- midite, prefentent des differences tres-grandes relative- ment a la quantite et au degre de liquidite des fucs fali¬ vaires et gallriques. Les perfonnes feches et bilieufes, dont les organes font tres-irritables et dont la chaleur propre eft plus ardente, dont les evacuations inteftinales font plus habituellement d u res et feches, qui font ordi- nairement conftipees, ont befoin d’une plus grande quan¬ tite de liquides aqueux et frais. La proportion des boif¬ fons aux alimens doit enfin varier felon 1’influence des faifons et de l’etat de l’atmofphere. On peut cependant pofer en principe, i°, qu’une quantite de boiffon qui excede trop la mefure des befoins naturels, cnerve les \ digeftions, et favorife les alterations fpontanees des ali¬ mens qui fejournent dans l’eftomac, furtout quand ce wifeere a peu adlivite ; 20, qu’une quantite de boiffon infuffifante prolonge le fejour des alimens dans la cavitc galtrique, et entretient le fentiment de plenitude qui en eft la fuite. Mais il faut furtout, a cet egard, fe mettre en garde contre l’habitude qui outrepaffe plus fouvent la mefure qu’elle ne refte en-de$a; connaitre, par fon experience, quelle quantite de liquide eft ia plus favora¬ ble ; favoir que la foif que donne l’ufage des fubilances feches, en epuifant fur-le-champ les organes falivaires, n’eft fouvent que momentanee, et fe difiipe en peu d’in- ftans par le renouvellement de la falive. Ces oblervr.tions font importantes pour ceux dont les digeftions font lentes, 1 imparfaites; 103 PATHOLOGY, imparfaites 5 pour ceux qui font fujets aux aigreurs, et cliez qui les fonftions de l’eftomac font aifrfment trou¬ bles par la fuperfluite des liquides.” (Tom. iii. p. m.) It is fuppofed too, that the rapid drinking of fluid is lefs falubrious than gradually fwallowing it, as the for¬ mer practice tends to produce dijlenlion of the (lomach ; but of this dillention we have no very unequivocal proof. Of the bad effects of too great a quantity of food we have frequent inftances, both in fudden and chronic af¬ fections ; and we have every reafon to believe that man¬ kind offend in general by taking too much food rather than by taking that of an improper quality. A negleft of attention to the quantity of the food, proportioned to the neceflity of each individual, is fooner or later fol¬ lowed by the molt ferious confequences. To the ftrong and robuft inflammatory difeafes happen, and all fuch as proceed from plenitude, as the gout, apoplexy, See. To the more tender and delicate, it is the parent of a nume¬ rous progeny of diftempers, affefting both body and mind ; there is fcarcely a malady that can be named which is not increafed by excefs of food, till the difeafe at length bids defiance even to temperance itfelf, and all prefeription. The hozv much , indeed, mull be deter¬ mined by every individual ; but thofe who are happy enough to abftain at the firli fenfation of fatiety, have made great progrefs in the art of maintaining fuch a command of appetite, as, under molt chronic indifpofi- tions, is one of the great aids of recovery ; and, in health, is one of thefureft prefervatives againft them. To the delicate and valetudinary the confideration of the quantity of the food is of frill more importance. They do not rife from rich and varied repafls with the fame freedom from uneafy fenfations as the robuft ; they are affefted with uneafinefs, fome in one way, fome in another, by the unnatural load. And we often hear them complaining of the ill effefts of this or of that par¬ ticular kind of diet, when, perhaps, their fufferings arife from the quantity of all, rather than from the difagree- ment of any. What renders an attention to the quan¬ tity of food in invalids (till more necefiary, is, that they are often fubjeft to a falfe appetite ; to a craving that does not arife from the demands of health, but from the mor¬ bid condition of the juices in the ftomach, which prompts them to eat more, and more frequently, than nature requires. Hence it happens that fuch people are often difpofed to take in much more than can be digefted, to devour their food rather than eat it ; by which means their fufferings are increafed, difeafe gains ground, de¬ feats every purpofe of the phyfician, and leads them into fome permanent and incurable malady. The time of eating is another grand confideration. It is well afeertained that a periodical aftion exiftsin the different fecreting parts of the body ; and that the fto¬ mach afts with different degrees of energy at different times, and according to fixed laws, can admit of no dif- pute; for not only does its being only required to aft at certain times indicate this, but the hunger we feel at the hour of repaft, and its abfence after a fliort time if not fatisfied, afford further corroboration of it. The cuf- toms of various countries changes too in refpeft to time ; and, provided the fame periods are obferved each day, this does not feem to influence our health in a great de¬ gree. Mr. Abernethy ftates the proper interval between each meal at fix hours, which reduces the meals to three in a day; and this feems to be the moft judicious arrangement which can be made, and which has indeed been generally adopted among the affluent clafles in this country, fupper being for the moft part difearded ; or perhaps we fhould rather fay, that the meal of dinner has been difearded, and an early fupper fubftituted. But two very moderate meals, at a fuitable diftance of time, would doubtlefs be digefted with much more eafe than one full meal, when the ftomach has been debili¬ tated by long falling, and has fuffered fatigue, together Vol. XIX. No. 1290. with the body at large, from the exertions of a long day. So that, as Dr. Fothergill has obferved, “ when people affure us they eat no fuppers, from obfervation I am led to fufpeft, that it would be better for them if they did, than to opprefs nature with a cumbrous load that may be much more detrimental.” This, indeed, feems to be pretty well underftood with refpeft to invalids and convalefcents, who are generally fupplied with fmall light meals at proper intervals, rather than have all their diet crowded into one late dinner. We fhall juft infert a general view of the more com¬ mon fubftances ufed at meals, for the purpofe of confult- ing the health of thole perfons who, though not ill, find the gaflric funftions eafily difturbed. The general breakfaft of people, from the higheft to the lowed, is tea, coffee, or chocolate. There are, of courfe, many exceptions ; fome for one reafon, fome for others, making choice of other fubftitutes, as their experience or opi¬ nions guide them. To thefe articles, bread of fome kind, with more or lefs butter and fugar, is commonly joined to make up the meal. From many inconteftible proofs that butter in confiderable quantities is injurious to con- ftitutions not ftrong, it is fparingly ufed in many families. It is found by many to be very difficult of digeltion, ef- pecially when toafted before the fire, or fried, as well as in fauces. Many people, apparently robuft, and whole organs of digeftion are ftrong, often find themfeives much difordered by large quantities of butter. Nothing more fpeedily and effeftually gives the fick head-ache, and fometimes within a very few hours. After breakfaft, if much toaft and butter has been ufed, it begins with a Angular kind of glimmering in the fight, objefts fwiftly changing their apparent pofition; giddinefs then comes on, head-ache, and ficknefs. An emetic, and warm water, foon walh off the offending matter, and remove thefe diforders. Thefe are circitmllances Which very of¬ ten happen to people who are inattentive to the quantity of butter they eat at breakfaft. A moderate quantity of frelh butter, with bread expofed as little to the fire as poflible, or not at all, appears to be wholefome, and is capable of becoming, with the other aliments, as loft and inoffenfive chyle, perhaps, as any part of our diet. The fame thing may perhaps be faid of coffee as of tea; the heat, the ftrength, and the quantity, make it un- wholefome or otherwife. There are nations who alrnoft live upon coffee, as others do on tea; and among neither are any difeafes prevalent that can juftly be aferibeu to thefe ingredients in the common courfe of living. There are, however, individuals of peculiar conftitution, in whom the Indian tea excites various unpleafant fymp- toms, as head-ache, rellleffnefs, &c. and feveral Britilh plants have been recommended as fubftitutes, and ufed with advantage. But Dr. Reid, in his Effuy on Hypo- chondriafis, fays, “ I am inclined to think that there are many cafes in which a tafte for tea ought to be encou¬ raged rather than condemned. This tafte has a tendency to preclude the more prevalent, and after all more mif- chievous, propenfity for vinous ftimulation. Many per¬ fons, diftinguilhed lor their longevity, have been known to indulge habitually in the ule of tea; which we may account for, not from its being in itfelf a wholefome beve¬ rage, but from afondnefs for it generally implying a dif- talte for potations of a much more decidedly pernicious nature. Tea will produce, in fome very irritable frames, an artificial (late refembling intoxication ; but it is a cloudlefs inebrity. Tea removes the film from an eye that has been obl'cured by a grofs and ftupifying intem¬ perance, and tends to improve a fufeeptibiiity to the true relifh of focial and intelleftual enjoyment.” It (hould be recollefted, however, that every vegetable infufion of this fort, is but warm water, rendered more palatable by the aroma of the herbs fo infufed ; and that there is little or no nutriment conveyed by them to the body, except what is contained in the fmall portion of milk and fugar added to them. Thefe liquors, then, (hould be conii- E e dered 104 PATHOLOGY. dered as the mere beverage, by which the folid portion of the breakfaft, the bread, See. is to be diluted, and its digeftion aflifted ; and it would be advifable for the deli¬ cate and valetudinary to curtail the liquid and augment the folid part of a tneal, which is to fupport them during the exertions of the day, rather than to fill the ftomach with a diluent and narcotic liquid, at once failing to nourifh the body, and deprefiing the aftion of the ftomach, where little is taken befides. But the effefts of improper conduft in refpeft to thofe things which now conftitute our breakfafts are of little confequence, compared to thofe which arife from the well-covered table at dinner. The indulgences of break¬ faft fupply but very few materials for deftruftion ; but the repeated exceffes at dinner are ferious affairs. And although, as we have before ftated, the quantity of food is the point to be principally regarded ; yet the quality is by no means a matter of indifference to the valetudi¬ nary. The principal admonition which the late Dr. He- berden deemed it neceffary to imprefs on the minds of delicate perfons and invalids, was to avoid all thofe ar¬ tificial ftimulants of the appetite, which excite the de- fire for food beyond the fimplecall of nature, and there¬ fore beyond the natural powers of the ftomach to digeft. Such are all made difhes, and condiments of the more poignant qualities ; nor is variety of difhes lefs perni¬ cious, upon the fame principle. It is probable that, in their nature, aromatic vegetable condiments, or fpices, are lefs pernicious to the organs of digeftion, than the various modifications of alcohol, or fpirits ; but the mif- chief which they occafion indireftly, by leading to excefs, is unbounded. This excefs is ftill more pernicious, now that the hour of dinner is poftponed to the evening; for the ftomach is enfeebled by the longabfence of ftimulus, and by fympathizing in the fatigue of the body, fo that its power of digefting a copious and heterogeneous mafs is greatly diminifhed. It is loaded, and diftended, and oppreffed ; and the body, in its turn, fuffers with the fto¬ mach. Hence, we fee the flufh of the countenance fuc- ceeding to a late and copious dinner ; the indifpofition to any exertion, mental and corporeal ; the general op- preflion of the animal powers; the general fenfation of heat; the hurried pulfe ; dry or clammy tongue; and other fymptoms of feverifhnefs. It is moft obvious, that the daily, or even frequent, repetition of fuch a diforder, (for it is, in faft, a morbid condition which is thus produced,) cannot be fuffered, without injury to the conftitution. Some of the common articles of diet require a little attention. Bread, the ftaff of life, is not the ipoft eafy of digeftion ; if taken in confiderable quantity, very ftrong organs are requifite to convert it into nutriment, and more efpecially when it is new, for then it is of a glutinous and heavy nature, and extremely difficult of folution. Cafes have been recorded, indeed, in which an immoderate quantity of frefh-baked bread proved the caufe of death. (See London Med. Journal, vol. i. p. 333.) In weak ftomachs a large proportion of ftale bread is indigeftible 5 it turns four, produces the heart-burn, flatulencies, and interrupts the perfect concoftion of every thing elfe. On this principle, the neceftity of pay¬ ing much attention to this capital article of diet ought to be inculcated on valetudinarians in general ; never to abftain from it wholly, but to ufe it with moderation; to confider it as one of thofe things which, fparingly ufed, is extremely neceffary and beneficial ; if otherwife, the fruitful fource of many complaints, which are little fuf- pefted from this caufe. In this country, animal food, of one kind or another, conftitutes the chief part of our nourifhment. That there are forne kinds of more eafy, fome of harder, di¬ geftion, is well known to every one; fo that it is unne- ceflary here to particularize them. The young of animals is generally confidered as more eafily foluble than the old; but in ftomachs difpofed to acidity, this does'not appear to be the cafe. Animal food is rendered more digeftible, by approaching to a ftate of beginning putrefaftion ; hence, the flefli of animals recently killed is lefs eafy of digeftion than that which has been kept for fome time; and hence, alfo, the flefh of an animal which has been hunted, or has ufed any violent exertions before death, is more tender and wholefome than one which has been in confinement ; for, after fuch exertions, the mufcular or fieftiy parts are difpofed to go fpeedily into a ftate of putrefaction. It muft not be forgotten, however, that this remark is applicable only to cafes where the ftomach is quite healthy; there being every reafon to believe, that, if any degree of gaftritis is excited, putrifying meat would prove violently ftimuldting. In refpeft to vegetables, the beft rule is to ufe thofe which beft agree with each particular conftitution. All the vegetables brought to table, which have been ren¬ dered foft by boiling, are readily digeftible. The raw ve¬ getables, ufed in falad, &c. are fomewhat lefs fo ; but, unlefs where the ftomach is much difpofed to acefcency, they are generally wholefome. “ On this head,” fays Dr. Fothergill, “ I have only one ftiort caution to give. Thofe who think it neceffary to pay any attention to their health at table, fliould take care that the quantity of bread, and of meat, and of puddings, and of greens, fliould not compofe each of them a meal, as if fome were only thrown in to make weight; but carefully to ob- ferve, that the fum of all together do not exceed due bounds, orincroach upon the firft feelings of fatiety.” With refpeft to fruit, it is doubtlefs wholefome in its ripe ftate; efpecially if taken in the forenoon, orin- ftead of a meal. But, like other agreeable and nutri¬ tious fubftances, it muft prove injurious, when added to the load of the ftomach, after a plentiful meal. Much might be faid about the comparative advantages of the different kinds of liquor ufed at table. The great objeft of drink at our meals is to dilute the aliment ta¬ ken into the ftomach, and thus render it more capable of digeftion. It is too often, however, ufed for a very different purpofe; namely, to ftimulate an imperfeft ap¬ petite, and to enable the ftomach to receive with relifti what, in its unftimulated ftate, it would loathe and re- jeft. Inafmuch, then, as drink is conducive to excefs in eating, it is pernicious to take large and frequent draughts of any liquid during a meal. Dr. Fothergill has laid down a few limple rules in refpeft to drink. “ The lefs quantity of fermented liquors we accuftom ourfelves to the better. Abftain from fpirits of every kind, however diluted, as much as may be. Where mild well-brewed beer agrees, to keep to it as a beverage. Where water does not difagree, to value the privilege, and continue it.” By thofe who recommended drinking not at, but after , meals, the interval ufually fixed upon is about two or three hours ; and we are moreover recommended by Mr. Abernethy to reft for a confiderable time after a meal, fome experiments made on dogs having proved that the digeftion of food in the ftomach takes place moft readily when the mufcular fyftem is in a ftate of inaftion. This liasjbeen objefted to, however, by a Mr. Hare ; but, as that gentleman has not tried the experiment over again, his objeftions are not valid. It feems to us, that the natural difinclination to move which we all feel after partaking of food, and the frequent eruftations, &c. which exercife produces when ufed during the fame pe¬ riod, fufficiently prove the correftnefs of Mr. Aberne- thy’s opinions on this fubjeft, without any appeal to ex¬ periment. The day, then, according to the view taken by the diftinguifhed gentleman juft mentioned, will be thus divided 1 The early part of the morning is to be devoted to exercife. Half an hour’s reft being premifed, breakfaft is to be procured. Reft again becomes necef¬ fary for two or three hours. Exercife again Ihould then be had recourfe to, until within half an hour before din¬ ner, the latter period being as before devoted to quief- eence» PATHOLOGY. cence. The fame round of employments to be continued until the third meal of the day, which is fuppofed toconfti- tutethelaft. According to this arrangement, the intervals between breakfaft and dinner, and between dinner and Aipper, (or tea,) will be each lix hours. See Abernethy on the Conftitutional Origin of Local Difeafes. We have to give our fmall tribute of encomium to this plan of life, being well allured by experience of its i'alutary and beneficial operation. It is very remarkable, but no lefs fatisfaddory, to find, that the habits which ex¬ perience has proved to be molt conducive to health, coincide completely with the practice founded on reafon- ing ; the trainers of our pugilifts having long fubmitted their pupils to rules very fimilar to the dietetic ones juft mentioned, and truly we can fcarcely find any-where elfe fuch ftrong proofs of their propriety. A bloated drun¬ ken fellow, whofe hours are perpetually occupied with debauch, and whofe frame evidently betrays the baneful effects of intemperance, fubjefted to three months training, that is, to the influence of regular and power¬ ful exercife, falubrious air, wholefome and fparing fup- plies of food, reftrifted in drink to water, and perhaps a few glaffes of wine, becomes developed in his mufcular ftrutture to an aftonifliing fize : he affords a ftudy for the painter which almoft equals the boafted ftatues of Italy; his Ikin acquires a fairnefs which might add beauty to our falhionable females ; and indeed the whofe appear¬ ance of the man is changed “ quanto ab illo Hettore.” In recommending, however, the above, we are aware, that they require much modification in their application to morbid ftates, becaufe the digeftive functions are in¬ fluenced in various and in oppofite modes, according to fex, age, habits of body, and habits of life. Though the refults of chemical analyfis, in regard to the nutritious parts of our diet, do not furnilh much practical information, it may be proper to advert to them with a view to future generalization. The food of man conlifts of feveral unchangeable principles, foreign to the bufinels of nutrition, combined with others in which the nutritive power refides. The latter varies in its characters and proportions. Mucilage, gelatine, gluten, albumen, fecula, fibrine, fugar, and the bafe of oxalic acid, are the general modifications under which the nutritive fubftance prefents itfelf. Each of thefe varies according to the nature of the heterogeneous prin¬ ciples with which it is aflociated. In the numerous plants which do actually, or which might, lerve for food, mucilage fometimes exifts alone, or mingled with extractive, colouring, acrid, bitter, or odorous, matters; or diluted with various proportions of water. It is often united with oxalic acid and fugar ; fometimes with a very aCtive volatile principle of a very acrid tafte and penetrating odour. Laftly, it furnilhes the matter of gums and vegetable jellies ; in one of which the nutritive principle is imperfeClly formed, while in the other it is brought into a very fmall volume. Gum tragacanth, feneca, cherry-gum, &c. are examples of this matter. It is no-where cultivated, nor even collected, for food ; fo that we might be apt to confider it as inca¬ pable of affording any nourifliment, if it were not known- that the caravans eroding the fandy deferts of Africa, over which they have brought gum feneca, have in many inftances loft their way, exhaufted their provifions, and been obliged to live on this gum for many weeks, having nothing elfe but water alone, and a very fparing fupply of that. Mucilage is aljo contained in moft vegetable juices, and in the Items and other parts of plants. In the flelh of animals which we ufe for food, the ge¬ latine is united with fibrous, extractive, faline, and earthy, particles. It is mingled with fat, and with ferous or lymphatic fluids. It is found in various degrees of te¬ nacity and confidence; in which it determines all the fenfible differences of the white organs, which contain an abundance of gelatine. In a word, it forms the animal i 105 jellies, which conftitute a mild, light, and wholefome, food. Vegetable gluten is always found combined with other fubftances folublein water, without which it could not be diffolved in, and blended with, our juices. It abounds in the gramina, where it is united with fecula, extractive principle, colouring matter, mucilage, and an earthy fubftance. The albumen of animal matters refembles, in many points, the vegetable gluten. The whole white, and a great part of the yolk, of an egg, are a compofition of albumen, and colouring and oily principles. The cafeous matter of milk is a modification of albumen : which, together with the principles of butter and fugar, compofes that foft etnulfive liquor, fo favourable to the conftitution of infancy. The moft nutritive plants are thofe whofe bafe and prevailing principle is the amyla¬ ceous fecula. It exifts fometimes completely pure, and free from extraneous admixture ; fometimes united with mucilage, oils, or gluten ; fometimes with fugar, extrac¬ tive or colouring matters; fometimes with earthy, acid, or faline, principles ; and very rarely with noxious or poifonous matters. Wheat is compofed of gelatinous matter and fecula. Thefe two principles, aCted on by the fermentative procefs, form bread, the nutritive qualities of which are not furpaffed by any vegetable fubftance. It is fo much the more proper for animalization, inafmuch as the fermentation has already brought it into a ftate fit for decompofition. The principle now alluded to, which conftitutes the farinaceous matter of vegetables, is contained, perhaps, in the largeft proportion, in rice ; and wheat is the next to this. Other grains are only fubftitutes for thefe ; ex¬ cept maize, which is eafily cultivated, and contains much farinaceous matter. The legumina contain much of the fame principle ; as alfo nuts, and the feeds of the cucur- bitaceae and poppy, although not ufed for food. It exifts, probably, in the Items of fome plants, as thepalmse, from the expreffed juice of which fago is formed ; in the roots of many claffes, as the potatoe, yam, and pignut, in which it is very abundant. The fibrine of the mufcles and blood partakes of the properties of gluten and fecula : it admits of a very fpeedy aflimilation, and exerts a more marked, rapid, and exten- five, influence on the ftrength in general, than any other food; yet it refifts the digeftive powers, when, deprived of gelatine or dried, it is reduced to a hard coriaceous fubftance. It forms a clofe and firm, but delicate and divifible, texture, in the mufcles of healthy animals, which form a light and fucculent kind of food. An extractive colouring matter generally adheres to the fibrous fub¬ ftance ; and the differences in its quantity or quality pro¬ bably influence the appearance and nutritive powers of our various animal foods. Sugar, and the oxalic bafe, which can hardly be fepa- rated from it, are produced by both kingdoms. The ve¬ getable acids are convertible into a fugary fubftance, which bellows on them whatever nutritive powers they may poffefs. Other acids, befide the oxalic, are unfit for nou- rilhment ; and they only acquire that property by an ad¬ mixture of the latter or of fugar or mucilage. The fame principles exift in various proportions in the fruits em¬ ployed for food. The refpeCtive quantities of mucilage, fugar, acid, and water, indicate how far they are fufeep- tible of digeftion, and, confequently, nourilhing. Sugar exifts in moft vegetables ; but is moft abundant in the fugar-cane, from which alone it is furniflied to any great amount, in the fugar-maple, and the beet-root. Except¬ ing whatisfupplied from the vegetables above mentioned, and which hardly forms the food of any perfon, its fources for the purpofes of food are not very general, being confined principally to dates, grapes, figs, and fome other fr.uits. Fruits indeed, in general, contain fugar; many of them in fufficient quantity to afford confiderable nourifliment. But the three fpecies juft enumerated are thofe 106 PATHOLOGY. thofe on which many individuals live almoft entirely ; the fugar being nearly their only nourifhment ; this obferva- tion holds with regard to dates in 1'ome of the African tribes, grapes in fome parts of Portugal and Spain, and figs in Greece and the Grecian iflands. Exprefl'ed oils, found in vegetables, are alfo capable of being digefted ; the feeds containing them, and especially nuts, are in many inftances the principal food of the in¬ habitants of a country, as cocoa-nuts in America and the Eaft. Thefe feeds indeed contain farinaceous matter, but in too ftnall proportion to afford nourifhment of it- felf. The oily animal fluids alfo afford nourifhment ; the molt common fource of thefe is the fat of meat and butter, but fome of the Ruffians and the Greenlanders drink with avidity fpermaceti and train oil. As rules for diet and exercife are attended to chiefly by valetudinarians and the aged, we fhall notice a publi¬ cation which appeared in the year 1758, called “The Old Man’s Guide to Health and longer Life.” The au¬ thor very properly divides his old men into two regi¬ ments, the thin and the grofs, to each of which he pre- lcribes a different regimen; the following rule, however, being common to both ; “Ufe no butter at breakfaft, if you wifli to preferve an appetite for dinner ; and, in pro¬ portion as you ufe more or lefs (butter), fo will your feelings be.” The author goes on ; “ The grofs old man fhould take his exercife chiefly in the forenoon, with as little nourifhment as poflible ; the thin old man fhould have a light breakfaft, but take his exercife after dinner. The thin old man cannot fleep in the morning ; the grofs man cannot rife early, unlefs he fleeps in the day-time.” The frequent notices in newfpapers of individual in¬ ftances of extreme old age, as well living as dead, have led us fo think that much ufeful information might be elicited from a narration of the molt elfential circumftan- ces ami habits of life of thofe who have thus fo greatly exceeded the ordinary limits of human exiftence ; fuch particulars, for inftance, as quantity and quality of food ; degrees of abftinence and indulgence in animal or intel¬ lectual enjoyments ; of exercife and labour, or of feden- tary inactivity ; and laftly, the proportions of health and ficknefs. Now, although great uncertainty may arife in afcertaining the accurate truth of many faCts, through the traditionary nature of the fources from whence they muft be collected, yet, among thofe who furnifh editors of newfpapers or other publications with cafes of long life, enough might be obtained, by any one interefted in the fubjeCt, to throw' great light on the at-prefent dif- puted queftion of relative caufes, and might tend to efta- blifli, at leaft with greater probability than yet exifts, the quantum of influence which the moral and habitual ope¬ rations and regulations of the animal economy poffefs over the peculiar idiofyncracy of that economy itfelf. We are not, certainly, fo fanguine as to expeCt from any combination of faCts, however numerous and well at- tefted, that mankind will ever regain the art of living to Methufelah’s age ; no, certainly not; thofe were the days of miracle, long lince found ufelefs : but if, from a com¬ panion of a multiplicity of various and oppoling truths, fome certain general principles could be difcovered, on which the prefervation of human life, and, what is Hill infinitely of more importance than mere length of life, its healthful fecurity from the afflictions of bodily difeafe and moral fuffering, could be proved to depend ; then, inftead of merely exciting a momentary feeling of wonder, like the prelent barren ftatement of the years an individual has held his being, fuch a concentration of prominent circumftances attendant on lengthened exiftence would become the precurfor of a new era, both in the fcience of medicine and in that of the happinefsand well-being of univerfal man. We are aware that the relater of any inftance of longevity could do little more than colleCt the circumftances connected with it : to combine and de¬ duce muft be the work of a mind in full pofleffion of the aggregate mafs of particulars, and qualified to draw in¬ ferences from them. After diet and exercife, the remaining numerous caufes of difeafe in the digeftive organs refolve themfelves for the moft part into the effeCts of fympathy w'ith or dependance on the aCtion of various other parts. The cerebral ftruc- ture forms one of the leading and moft important. It were of little importance to fpeak here of the numerous complaints incidental to men of ftudious habits. It muft be expefted that, feeing that mufcular contraction acts a very important part in the human frame, and that the force of that action is increafed (within certain limits) in proportion to its exercife, therefore indolence muft be productive of hindrance to the due performance of vaf- cularand abforbent functions of the body. It is further to be confidered that nervous influence is neceflary to fecretion ; and on fecretion the hunger, digeftion, &c. may be faid to depend. No w, it is well known that the intenfe aCtion of the brain in performing mental pheno¬ mena do effentially and fometimes completely difturb the tranfmiflion of nervous influence. Of this we have the moft frequent examples. Every one knows how often enthufiafts in fcien-ce are led to forget the precife hours of refrefliment, and how much the man of literature in this refpeCt differs from the bon vivant. It would feem (to ufe a figurative expreflion) that the brain was fo ab- lorbed in the fubliinity of thought, that it had no time to perform its corporeal and coarfer funftions. But of courfe thefe functions are requifite in the higheft degree, and the non-performance of them fubjeCts the ftudious man to difficult and uneafy digeftion; and fhould there¬ fore be encouraged by regular habits and by mufcular aCtion. On the other hand, the want of due aCtion in the ra- tiocinative powers feems to allow increafed nervous fup- ply to the fecreting organs. Thus many mentally-indo- lent perfons have voracious appetites ; and indeed we cannot help thinking that the amazing digefting powers manifefted by our peafantry (in the generality of whom we fee correfponding inactivity of mind) depends in a great meafure on the unexercifed ftate of the intellect. This propofition it would be perhaps difficult to demon- ftrate, becaufe the faCts under confideraticn may be ex¬ plained on other grounds. It is worthy of remark, how¬ ever, that we fee none of this exceftive defire for food ma¬ nifefted by men who, engaged in occupations equally la¬ borious and healthy as the ploughman’s, are called upon moreover by neceffity or ftimulated by education to the exertion of their minds. It has been aflerted more than once, that abftinence fits the mind for increafed exertion. This notion can only be admitted with fome reftriCtion. To a great de¬ gree it is undoubtedly true, becaufe, according to our prefent methods of life, it may be reckoned that the ge¬ nerality of perfons are inclined to a plethoric ftate of the vefiels of the head, and hence a low kind of living may, to a certain point, tend to revivify the exhaufted brain. This beneficial refult may arife too from tranquillity being reftored to the extenfive nervous expanfions of an irritated ftomach, which propagated their morbid con¬ dition to the brain ; or, again, it may prevent for a time the fupply of noxious materia to the vafcular fyftem of the brain. In the latter mode efpecially it is probable its effeCt is very frequent; for there is ftrong ground to conjecture that many mental diforders arife from the laft caufe. The effeCt which the deranged liver produces on the brain can only be accounted for on the fame fuppo- fition ; i. e. that of abforption and local application. This agency of the liver on the head is corroborated by the refpeCted teftimony of Dr. James Johnfon. See his work “ On the Dileales of Tropical Climates,” p. 189. He fays, fpeaking of hepatic derangements, “ The whole of the literary world, from the poet in his garret to the learned prefident in his hail, feel more or lefs of its ef¬ fects. PATHOLOGY. feds. This deficiency in the fecretion of bile, the con- Sequence of mental exertion and corporeal inadivity, is evidently the morbus eruditorum, * which ficklies o’er, with the pale caft of thought,’ 'the countenances of the ftu- dious, who wafle their hours and their health by the midnight lamp ! To them I need not defcribe the ma¬ lady ; they are too familiar with its various, fymptoms. But few of them are aware how far material caufes can influence intelledual ideas. If I wi(h to exert, on any particular occafion, the whole force of my memory, ima¬ gination, perception, and judgment, I know, from re¬ peated experience, that by previoufly emulging the liver and its duds, and carrying off all bilious colluvies from the alimentary canal, by mercurial purgatives, which alfo excite a brifker fecretion in the chylo-poi'etic vifcera, I am thereby enabled to avail myfelf of thofe faculties above mentioned, to an infinitely greater extent than I otherwife could. This is no theoretical fpeculation -5 it is a p radical fad. It may help to explain the great ine¬ quality which we often obferve in the brighteft effufions of fancy 5 and fhew us why even the immortal -Homer fometimes nods.” The ftomach is influenced by fympathy with other parts to a very great degree: iftly, by the (late of the Ikin ; sdly, and mod materially, by the ftate of the lungs; and, laftly, by the ftate of all the coliatitious vifcera. Among thefe the moft ftriking is the liver. It is fcarcely fair to infer, however, that affedions of the alimentary canal are produced by the coliatitious vifcera through the medium of the nervous fyftem ; fince the unnatural fecretions poured into it by them may produce all the difturbances we have occafion to witnels. From the na¬ ture of this ftrudure it is verjt evident, that each of its fecondary procefles is dependant on the due performance of the primary ones. Thus the faliva cannot mix with the food in a proper manner until the teeth have performed their office; the ftomach cannot ad if any impediment exifts in the pharynx ; nutrition cannot take place if the adion of the ftomach fufpended or materially depraved ; and fo on. Hence, then, the belt mode of considering thefe difeafes is according to their anatomical relation to each other; fo that difeafes of the teeth, faliva, pharynx, and fo on, will form the order of our arrangement. Before enteringon them, however, we have a few remarks to make on fome grand divifions in regard to the patho¬ logy of the mucous membrane of the ftomach and bowels. To thefe derangements the fweeping term indigeftion has by moft writers been applied, with a view of compre¬ hending the whole of this varying and numerous clafs. We are indebted to the continental writers for fome very material elucidations of the nature of gaftric affedions. We find, in the work of Brouffais efpecially, a moft able expofition of the chronic inflammation of the ftomach ; a difeafe which had been greatly overlooked, and perhaps confounded with thofe inexplicable modes of adion which have been accounted for on the unfatisfadory af* fumptions of want of tone, laxity , weuknejs, or delicacy , of ftomach, &c. It is to be doubted if the ufe of thefe vague expreffions has not induced many to adopt thefti- mulating, the purgative, or the ftomachic, plan, to the manifeft injury of their patients, when cooling and un¬ irritating meafures were more appropriate. Gaftritis, in the common fignification, is certainly a difeafe of rare occurrence, and is as dangerous as rare; but this applies only to its moft acute and. violent form. Brouffais has eftablifhed the fad, by repeated diffedion and obferva- tion, that this inflammation exifts in various forms ; that it is capable of going on to produce diforganization of the mucous expanlion of the alimentary canal ; that, on the other hand, it may produce iymptoms and effeds re- fembling acute fevers. He has traced the gradual (hades and gradations, from the violent and acute form of inflam-: mation to which old nofologifts have applied the word gu frit is, down to thole troublefome though flight a»- Vol. XIX. No. 1291. 107 pearances which we have been accuftoined to call indigef- tion. The notion of a flight modification of gaftritis had indeed been entertained by Cullen ; for he fpeaks of ery- thematic inflammation of the ftomach ; but it does not appear that this idea was ever followed up by him, or applied with any advantage to practice. With refped to the exiftence of this affedion, we fhould, a priori, conclude that inflammation of the. ftomach would be a difeafe of frequent occurrence, becaufe that organ is of¬ ten oppofed to fubftances of a highly-irritating nature, becaufe its vafcular fyftem is much developed, and be¬ caufe it poffeffes a high degree of fenfibility. Indeed we are inclined to think that many difturbances in the ali¬ mentary canal may be traced to inflammation in the firft in fiance, and that the ftate of atony of the digeftive appa¬ ratus is often the refult of that previous over-adion . To generalife thus would, however, in the prefent ftate of our knowledge, be premature; for we fhould know precifely in what proportions the abforbent, the vafcular, or the nervous, fyftem, of this digeftive tube, are im¬ plicated in difeafe, ere we could ftate the fweeping cou- clufion, that inflammation is the general forerunner of gaftric difturbance. Moreover many cafes will occuh' to the pradical phyfician in which no inflammatory adion was in the leaft degree apparent. Perhaps then the moft appropriate arrangement will be into, 1. Chronic inflammation of the alimentary canal ; 2. into difturbed fundion of that canal arifing from un¬ known modes of adion ; and, laftly, into fympathetic propagated difeafe arifing from, or communicated to* other parts. It is with the fecond only that we have now to do. The firft, as being conneded with general in¬ flammation will be treated of under gafritis; and the third will receive frequent iiluftration in almoft every difeafe in our catalogue. It is however of the utmoft import¬ ance that the two dates of atony and excitement fhould be well difcriminated ; and on that account we cannot avoid giving in this place a fhort diagnofis of the two kinds of difeafe. Chronic gaftritis differs from the Ample fundional difturbance of the ftomach, in that a fenfe of pain (of various kinds however) is almoft continually prefent, and. that the fenforial fundions and the pulmonary fyftem- are more powerfully affeded : the (kin exhibits more of heat ; in the early flages, the circulation is fomewhat af¬ feded ; third and evening exacerbations are frequently prefent ; and vomiting is feldom abfent. Moreover the fympatheticf irritations that arife from the irritation of the ftomach, prefent more of an inflammatory charader. It will eafily be feen, that every one of thefe fymptoms is equally prefent in various kinds of Ample indigeftion ; but the connexion of the whole mull be taken into con- fideration. The excellent effeds of cool drinks, &c. in allaying the difeafe, feems to prefent another difcrimina- ting point, fince that effed is feldom experienced in Am¬ ple indigeftion. The fame cautions are pradically neceffary in treating the mere fundional difturbances of the lower parts of the alimentary canal, and chronic enteritis, colonitis, &c. but, as this is not the place to enter into difcuffions on inflammation, we merely point out the fad that dif- crimination is neceffary in thofe difeafes. The fundional difturbances of the alimentary canal are fo numerous, and fo anomalous in their charader, that they almoft baffle defcription, and we (hall meet with no order of difeafes .in which our nofological arrangement is more itnperfe.d than in this; for not only do many of the in¬ dividual difeafes run into eacli other, but fome of the fpecies, we ace inclined to think, are merely fymptoma- tous. Cullen arranged thefe complaints in a very gene¬ ral way. Mr. Abernethy too, though he has written fome of the heft hiftories of them which we have, did not at¬ tempt to claffify or arrange the different kinds, though he expreffed a hope that fuch difcrimination might after¬ wards be made. More recently, in the interfiling work Ff of 108 P A T H O of Dr. Wilfon Philip on Indigeftion, we meet with want of due arrangement. The genus Limojis of the prefent fyftem will be made to comprehend molt of thefe difeafes, though perhaps the fubdivilions are imperfedt. We have not introduced any account of thofe various diforders which arife from, and are traceable to, derangement of thefe parts; fora dileafe cannot be much altered in its character by remote caufes ; and hence the terms Dyf- peptic-FhthiJis, cum multis aliis, feems mifapplied ; not that we forget that complaints ariling from indigeftion are mod frequently curable, but becaufe we hold it in- difpenlible to pay particular attention to the ftate of the laboratory of the fyftem in every clafs of complaint. The clafs Cceliaca is divided into two orders and feven- teen genera. Order I. Enterica, [from the Gr. eyripov, an entrail.] Diforders aft'edting the Alimentary Canal. This Order contains twelve Genera. Genus I. Odontia, [from o^ou;, a tooth.] Pain or De¬ rangement of the Teeth in their Sockets. This genus embraces feven fpecies. i . Odontia dentitionis, difficult or painful teething, is further divided into four varieties: a, la&antium ; /•?, puerilis; y, adultorum ; fenum. a. O. dentitionis ladlantium is a difeafe well known, and of frequent occurrence. It is caufed by the tenfe ftate of gum covering the tooth ; or, on the other hand, by the too-rebxed ftate, which allows the tooth to pulh it up and prefs on the nerves, without producing abforp- tion. It feems, too, that conftitutional dilturbance has a great (hare, by rendering the nervous fyftem particu¬ larly fenfible, in encrealing the bad effeCts of dentition. Children of plethoric and irritable habits are pe¬ culiarly obnoxious to this complaint, as alfo thofe in whom coftivenefs is prefent. It is remarked alfo, that rickety children cut their teeth at advanced periods, and with much difficulty; and it is popularly known that favourable dentition is indicative of future health. The following are a few of the morbid fymptoms of difficult teething; viz. Inflammatory fwelling of the gums, tonfils, and parotid glands; rednefs of the eyes and cheeks ; vomiting, griping pains, tenefmus, profufe diarrhcea with green evacuations, and fometimes oblti- nate coftivenefs and retention of urine. Fever, accom¬ panied with cough and other catarrhal affeCtions, hic¬ cough, univerfal or partial tetanus, convulfions, &c. are the fymptoms by which, according to the eftimate of fe- veral writers, nearly a third of children are deftroyed in difficult dentition. Thefe are the common fymptoms of difficult dentition ; but occafionally peculiar ones arife, which not unfre- quently fnblide as foon as the tooth is cut; as, for in- ftance, gutta rofacea, (Lorry, Trait, de Morb. Cutaneis, 1777. p. 41 1.) deafnefs ; amaurotic blindnefs ; enlarge¬ ment of the knees ; paralyfis ; and lamenefs of one or both legs. (Pafch, Abhandlung aus der. Wundarzney von. den Zahnen, S. 25, 36.) Aphthae of the mouth ; an inflamed tubercle over the tooth which is about to be cut; fuppuration, ulceration, and even floughing of the gums. Rachitis is alfo alleged to have its origin fome- times from difficult dentition. But we ffiould rather fuppofe that in the laft inftance the caufe had been tnif- faken for the effeif. The firft fymptoms are local, and appear to be accompanied with pain, as the child is reft- lefs, uneafy, and rubs his gums, and carries every thing to his mouth. There are alfo generally inflammation, heat, and fwelling of the gums, and an increafed flow of faliva. A general ftate of fever follows, which is fome¬ times flight and fometimes violent, and is very remark¬ able both for its fudden rife and declenfion ; fo that in the firft hour of his illnefs the child ftiall be perfectly cool, in the Tecond fluffied and burning hot, and in the third temperate again. The local fymptoms which enfue in diftant parts, are various and complicated ; for LOGY. the appearance they put on is in fome degree determined by the nature of the parts which they affeCh It is to be recollected, that the lymptoms of irritation from teething have often very clofely refembled inflam¬ matory difeafe, efpecially of the brain, fo that practition¬ ers ffiould in ail cafes take particular notice of the ftate of the teeth. The treatment of the difeafe is of courfe Ample ; namely, to keep the bowels open ; in plethoric children to apply a few' leeches behind the ears ; when much irritability prevails, a narcotic of the leaft ftimu- lating kind, as hyofeiamus, may be given. But the moll advifable ftep, in addition to the above, is to divide the gum over the tooth. The incifton is to be made with the common inftrument, well known by the name of the gum-lancet, which is far better for the purpofe than an ordinary lancet, as that is apt to cut the tongue and lips, efpecially when the child moves about much. The grinding teeth require a crucial incifion : all the others a Ample tranfverfe cut completely through the gum. The wound is then to be examined with the finger, in order to afeertain that no tenfe fibre over the tooth continues undivided. In this country practitioners feldom apply any thing to the incifion ; but abroad, it is not uncom¬ mon to put to it a mixture of lemon-juice and honey. A premature incifion of the gum foon clofes again, and therefore does little fervice ; but it is improbable that the cicatrix, thus produced, can be any impediment afterw’ards to dentition, as many have imagined ; for it is an eftabliflied faCt, that cicatrices in general are more dif- pofed to ulcerate and be abforbed, than the original parts of the body. Mr. Hunter, indeed, informs us, that he performed the operation above ten times upon the fame teeth, where the difeafe had recurred as often, and every' time with the abfolute removal of the fymptoms. No idle apprehenfions ffiould therefore deter us from divi¬ ding the gum, where there is any chance of benefit from the proceeding. At the fame time this is not recom¬ mended as a prophylactic meafure, but as being proper only when illnefs, fufpedfed to arife from dentition, ac¬ tually exifts. The life of hard applications, as biting the root of marfli-mallow's, fmooth corals, boars’ tulks, See. render the gums callous ; but more good might, perhaps, be de¬ rived, if fubftances with roughifti furfaces were employed. The anomalies which w>e remark in regard to the back- wardnefs, or on the contrary unufual forwardnefs, of den¬ tition, do not feem worthy of notice in this place, be¬ caufe they are fcarcely within the reach of medical affift- ance : it is ufually remarked that healthy children cut their teeth early ; while thofe who are rickety, or other- wife affefted with chronic complaints, are equally late in performing the fame procefs. The molt common or¬ der of the firft teething is as follows : In the fixth or fe- venth month after birth, the firft or milk teeth make their appearance through the gums. The two middle in- cifores of the lower jaw are thofe which moll frequently firft come out ; and, in the courfe of a few weeks, they are generally followed by the two middle incifor teeth of the upper jaw. At length, after fome months more, the lateral incifors and the canine teeth (how themfelves. The anterior molares, or front grinders, do not com¬ monly pafs through the gums until the child is a twelve- month old. (3. O. puerilis ; and y. O. adultorum. Thefe two va¬ rieties may be confidered together. It feldom happens that much irritation is produced in thefe advanced terms of dentition. Occafionally, indeed, the protrufion of the dentes fupientia, or “ teeth of wifdom,” in adults,, is fo long delayed, that, the jaw having ceafed to enlarge, and being completely filled with the other teeth, the preflure of the wife teeth on the coronoid procefs when they arife from the upper, and on the fuperior teeth when from the lower, produces a trifling inconvenience; but this is eafily remedied by freely opening the gum, or by extract¬ ing thefe ufelefs teeth. The PATHOLOGY. The fame variety, in regard to time of appearance, exifts in the fecond dentition as in the firft. The common pe¬ riod is from eight or nine to thirteen years of age. Many cafes of three or more dentitions have been record¬ ed on undoubted authority. O. fenum. The reproduction of teeth in advanced age is another curious but well-authenticated fadt. In general the teeth which appear at this period are irregu¬ lar and ufelefs. John Hunter, however, faw one cafe in which a complete fet arofe in both jaws. Dr. Good men¬ tions two cafes in which a few draggling teeth were cut at a very late period of life; and which were further re¬ markable on account of the patients recovering, the one her hearing, the other her fight; fenfes of which they had been for years partially deprived. For further cafes in which teeth were produced very late indeed, the reader may confult Yfabern, Journ. de Med. tom. xxv. p. 316. Nitzfeh, Ephem. Erudit. Ann. 1666, p. 175. Ephem. Nat. Cur. Dec. 11. Ann.iii. Obf. 15. and the Phil. Tranf. vol. xxvii. 1713. 2. Odontia dolorofa, acute pain in the teeth or their fockets. Dr. Good makes four varieties of this difeafe 5 viz. a, cariofa ; /?, catarrhaiis ; y, nervorum ; fym- pathetica. a. It appears agreed by the mod: enlightened phyfiologifts, that the internal part and fang of the teeth are vafcular, while the enamel is an inorganic fecretion. Caries there¬ fore may arife from inflammation of the tooth giving rife to abforption of the fubltance and enamel; or the fame procefs may take place from chemical folvents applied externally. We (hould be inclined to think that the former caufe is the moft common. The more remote caufes of the inflammation of the teeth are various, and many of them infcrutable. Heatand cold, which are tranfmitted readily through the enamel, are perhaps the moft frequent. Dif- ordered fecretion from thefalivary glands are perhaps the moft ufual caufe of decompofition of the enamel ; for we cannot fuppofe that the fubftances we fwallow, hetero¬ geneous as they are, can produce much effeCt in palling fo rapidly as they do through the mouth. It is fcarcely neceflary to remark that inflammation of the gums will generally communicate their morbid ftate to the teeth. By whatever means, however, as Dr. Good fays, a decay or caries of the teeth may be produced, it appears to ope¬ rate in three different ways : fometimes commencing in the internal cavity, and working its path outward ; fome¬ times out ward, and working its path within; and fometimes by a wafting of the enamel, and confequent denudation of the bony part. The firft is the leaft common affedtion, and is difcoverable by the appearance of the internal blacknefs through the external Ihell ; the third is more common than the firft, and the fecond the moft frequent of the whole 5 evincing, at its commencement, the ap¬ pearance of an opake white fpot through the enamel, which gradually crumbles away about the fpot, and thus difcloles that part of the body of the tooth which forms the original feat of the difeafe, and which, by its conti¬ nuance, converts the early fpot into a hole, and at length deftroys it altogether, or at leaft down to its neck, unlefs the pain produced by its progrefs compel the patient to have it extrafted before the difeafe advances thus far. It is of no practical ufe to infert the various remedies by which the pain arifing from denudation of the nerves of the teeth has been attempted to be alleviated. They are for the moft part of that nature which, by exceflively ftimulating the nerve, entirely deftroys its fenlibility. Hence, perhaps, the moft efficacious are the ftrong mine¬ ral acids, carefully applied by means of a pin or probe to the carious furface 5 but this requires that the gum, &c. (hould not exhibit any marks of inflammation. Small degrees of caries, or (light fiffures, may be relieved by filing, filling up with gold, See. Of courfe, however, the only radical cure, where much caries is prefent, is to extradt the tooth ; for the mode of performing which fee the article Surgery. 109 If inflammation have not produced caries (and there is often violent and excruciating pain irreferrible to de¬ cayed teeth), lancing the gums freely, and attending to the fympathetic adlion whence they derived their difeafes, e. g. difordered gaftric or uterine fundtion, will often effedt the cure. The inflammation often extends over the whole face, and is particularly diftinguilhed by the exafperation of the pain which warm liquids give rife to when applied internally. This is moft effedlually com¬ bated by cooling lotions and by purges. The ill effedls of the ufe of the ftimulating remedies in this kind of tooth¬ ache is exemplified (tronglyby the following cafe, extradled from the London Medical Journal, vol.iii. communicated by Mr. Fowler, of Princes-ftreet, Hanover Square. “ A gentleman whom I attended, wasafflidfed wuth the tooth¬ ache in the firft dens ltiolaris. Being much alarmed at the idea of extradtion, he applied to an old woman, who at that time was efteemed famous for the cure of the tooth-ache without drawing. She had applied her nof- trum to the tooth twice within the fpace of three days; and, on the fourth, he came to me, complaining of a lore mouth, telling me where he had been to get relief, and that the liquid which had been ufed was very cauftic. From the appearance of the violent inflammation, which had taken place from the difeafed tooth to the epiglottis, I advifed him to confult fome medical gentleman of emi-' nence immediately ; with which advice, I am forry to fay, he did not comply. Not hearing from him on the third day, I called (en paflant), but he w'.as too ill to be feen ; a derangement of intellects had taken place. I called again four days afterwards, and was informed, that he had died raving on the preceding day. I had every rea- fon to believe, that the fluid which had been inferred into the tooth with a view of deftroying the nerve, had pro¬ duced this tragical end.” y. Difeafe of the nerves of the teeth is perhaps the moft troublefome fpecies of tooth-ache. The appearances it exhibits are anomalous ; and the complaint is fo fre¬ quently aflbeiated with caries of the teeth, that its pre- cife nature is often unknown until fome of the teeth have been extradled without the leaft alleviation. This affec¬ tion arifes from the fame caufe as other morbid affedtions of nerves; often from gaftric, inteftinal, or biliary, derange¬ ment ; pregnancy, plethora, worms, &c. and is to be com¬ bated only by removing the caufe, anti by the ufe of re¬ medies having the effedl of allaying nervous irritation. As this affedtion feems, then, to arife from various caufes, it is capable of comprehending the other varieties men¬ tioned by Dr. Good. We (hall have occafion to fpeak more at large on this fubjedt when treatingof Neurotica. 3. Odontia lluporis, or tooth-edge, has two varieties : a,, a ftridore ; /3, a acritutide. The former, which is af- fociated in a remarkable manner with peculiar imagina¬ tions, is the fenfation we feel when the edges of two knives are rubbed acrofs, when we cut a cork, or rub our coat-fleeves together. Dr. Good mentions the cu¬ rious circumllance, that a friend of his experienced this fenfation in a remarkable degree from hearing a woman cry bullaces for fale. It is perhaps difficult to explain this phenomenon. It is moft probably fomehow connec¬ ted with fympathetic adlion between the nerves of teeth and ear; unlefs we could admit the notion of Hagerup, that the nerves of the teeth are auditory, in which cafe this operation of harffi founds might readily be accounted for As connedled with this point, we beg the reader to notice the conclufion of our article Dumbness, vol. vi. p. 117. j3. The latter variety is produced by moft chemical fubftances that can denude or diflolve the enamel. It is felt at the edge of the teeth, perhaps on account of the tbinnefs of the enamel at that parr. Morbid fecretions ejedled from theftomach into the mouth frequently caufe this unpleafant fenfation. Mechanical injuries, as gnaffi- ing the teeth, attrite the enamel likewife ; and it is laid to be a fymptom in rachitis, bilious diforders, See. The removal 3 110 PATHOLOGY. removal of the remote caufe is of courfe the only plan of treatment. Warm liquors, and the chewing of almonds, have however been recommended. 4. Odontia deformis, deformity of theteeth, from error, ftiape, pofition, or number. The teeth fometimes grow in a very irregular manner; as from the palate, underneath the tongue, or not upright in the gums. The latter circumftance is a very general confequence of neglecting to draw the firft teeth of children on the ap¬ pearance of the fecond. It may be remedied, when in a trifling degree, by pulhing the tooth from time to time towards its proper fltuation ; or, more permanently, by means of fome mechanical contrivance, as lilk thread or Bruner’s machine. A metallic plate anfwers the purpofe very well ; its width fliould be lefs than the height of the teeth ; its breadth equal' to three teeth; it is to be applied to the infide of fuch teeth as incline inwards, and to the outfldes of thofe which incline outwards; at the ends of the plate are two holes, through which the filk- t breads, fmeared with wax, are to be palled, and, after eroding each other, are to be tied over the oblique tooth. ^hen the teeth are fo far removed from the gums as to render thefe methods ineffectual, extraction is of courfe the only refource. Albinusrecords.au example, in which a tooth grew out of the maxillary procefs below the orbit. It was concealed until it made its way out in this extraor¬ dinary fltuation. Annot. Acad. t. i. p. 54. The teeth have fometimes been oblerved inverted, their bodies being fltuated towards the jaw. Pollich, Increm. Gjjium, p. 25. Albin. c. 9. PaIJin, c. 9. Sometimes the teeth are placed too diftant apart, fo that between their crowns large interfpaces are left. Thus, in children three years of age, the crowns of the milk-teeth are fo clofe to each other, that they are late¬ rally as it were in contact ; but, in children feven years old, there are wide interfpaces between them. The reafon of this is owing to the jaw increafing in fize, while the dimeniions of the teeth undergo no alteration. The fe¬ cond or permanent teeth, on the other hand, (at lead the firft twenty of them,) have larger bodies than the milk-fet. Frequently the tartar infinuates itfelf between the crowns of the teeth, and occafions a confiderable repara¬ tion of them. We need l'carcely obferve, that the cure requires that the tartar fliould be taken off, and the teeth reduced into their natural pofition. The deformity of which we are now treating, is occa- lionally afcribable in adult fubjefts to the preternatural breadth of the jaw, in which circumftance it is abfolutely incurable. Theteeth may be too crowded together, fo that their crowns are laterally in contaCf. This defeCt may extend to fome or all the teeth. The frequent confequence is, that the lateral margins of thefe parts become carious. This deformity arifes from the great width of the crowns of the teeth, and it may be afeertained by ocular examina¬ tion. In fome inftances, all the bodies of the teeth are preternaturally wide, in others only a certain number of them. It is caufed likewife by the uncommon fhortnefs of the jaw. It may be known by obferving that the crow ns of the teeth are not too large, and that the alveo- lary arches are ftrikingly diminutive. The mode of cure confifts in filing off a little of the lateral edges of the teeth affedled. Sometimes the number of the teeth exceeds what is the ufual fliare of the human fpecies in general; and this particularly occurs whenever the number amounts to more than thirty-two. Columbus has feen thirty-three; Fauchart, thirty-three and thirty-four; Bourdet, thir¬ ty-fix; and Ingraflias thirty-fix, including twenty-four grinders. In fome inftances, the exeeflive number is ow'ing to there being a double row of teeth. This malformation may happen to both jaws, or be confined to one. It has been noticed in both jaws by Munick, p. 144. Plinius, c. xi. p. 623. C. Bartholinus, p. 464, See. Arnold met with a boy, fourteen years old, who had all together fe- venty-two teeth in his mouth. There was a double fet of the incifores, canine teeth, and three pofterior grind¬ ers ; but the anterior grinders were triple : confequently there were counted in each jaw eight incifores, two ca¬ nine on each fide, and twelve molares. The incifores were not arranged in an even double row' ; but each row feemed irregular, and its order as it were promifeuous. The arrangement of the canine and grinding teeth was more regular. None of thefe teeth were affefted with caries. (Jbf. Phyf. Med. p. 69. See alfo Hunter, p. 115, 199, for examples of a double row of teeth. Bloch, Medicinifche Bemurkungen, p. 19. Triple row, Nean- der, Phyfic, Part II. Numerous and confufed rows, Eph. Nat. Cur. ann. iii. vii. viii. 5. Odontia edentula, or toothleflnefs. This fpecias confifts of four varieties, ct, Peculiaris ; from conftitu- tional defedt. S, A vi extrinfeca; from external vio¬ lence. y, A carie ; from decay. Senilium, from old age. In all thefe varieties, the affection feldom extends to the whole teeth, except in the cafe of old age. In the firft, or that from conftitutional defeft, a few only in one or both jaws, are left unprovided for ; while fome¬ times an effort to this purpofe is commenced, but not carried to perfeiflion. “ In the head of a young fubjeft which I examined,” fays Mr. J. Hunter, “ I found that the two firft incifor teeth in the upper jaw had not cut the gum; nor had they any root or fang, excepting fo much as was neceflary to fallen them to the gum on their upper furface ; and, on examining the jaw, I found there was no alveolar procefs nor fockets in that part.” Nat. Hift. of the Human Teeth, p. 8. It is obvious that the only method of remedying this defeft is by inferting fupplemental teeth ; as to which fee the article Surgery. 6. -Odontia incruftans, tartar of the teeth. Tartar is an earthy cruft, which adheres to the teeth. As it fills up the interfpaces of feveral of the teeth, and occu¬ pies their external furfaces, it is feldom obferved upon their infides. By the Greeks it was called odontolithos, from o^oi-s, a tooth, and Aiflo;, a ftone. By others it has been termed tophus ve 1 calculus dentium. With regard to the eftefts of the tartar, it difplaces the teeth, and renders them loofe and painful ; it alfo feparates the gums from the fangs, producing caries in the latter, and a bad fmell in the breath. In refpeft to colour, the tartar of the teeth is of three kinds, namely, dark-brown, yellow, and black. Since many perfons who never clean their teeth at all are not disfigured with thefe depofitions of tartar, it ap¬ pears that a peculiar difpofing caufe is neceflary for the occurrence of the complaint. It is moft likely that morbid ftates of the faliva are the moft frequent; for there are certain perfons, whofe teeth are conftantly in- crufted with tartar, notwithftanding they are in the con¬ tinual habit of waffling their teeth and mouths. Berd- more relates a furpriling example of this fort. A man, thirty-two years of age, had the teeth of each jaw coated with folid tartar, half an inch in thicknefs, both on the outfide and infide of the teeth, and on the furface of the gums, fo that the interllices of the teeth were altogether invifible. The gums were every-where pufhed off the teeth, and painful. The incruftations upon the incifor teeth were fo thick, that the lower lip was rendered more prominent. During a fortnight, Berdmore removed every day fome of the tartar from the teeth with an in- ftrument, and at length employed a dentifrice and brufh. The retraced gums were fcarified, and thus made to ad¬ here to the necks of the teeth. The patient was obliged to bruftt his gums and teeth three times a-day, partly with a view of preventing the new formation of tartar, and partly in order that the regeneration of the gums might be ftill more promoted. But, although the patient ftri&ly followed this plan, his teeth and gums, in the courfe of half a year, became again covered with an ex- tremely-thick coat of tartar. Berdmore was therefore under PATHOLOGY. Ill under the necefiity of recommending- the ufe of a ftiffier brufii, and a dentifrice made of (hells, for the purpofe of removing the tartar. With refpefit to the treatment of tartareous incruftations of the teeth in general, it is effential to remove the tartar, and clean the teeth well every day. It is alfo needful to correft the ftate of the falivary l'ecretion. Perfons who are in the habit of ufing acrid tin&ures or powders which diffolve the enamel, and make it porous, are frequently troubled with tartareous incruftations. The caufe being avoided, the mode of treatment is the fame as in the preceding cafes. This afte&ion fometimes arrives at fuch a pitch, that feveral of the teeth become concreted together. See Eultachius de Dent. cap. 2. 7. Odontia excrefcens. Varieties: a, fpongiofa; 0, extuberans. a.. O. fpongiofa is taken to apply to the difeafe which has been i'o well defcribed by Hunter as fcurvy in the gums, from its identity with one of the fymptoms of fea- Icurvy. It is not to be concluded however that the term is exactly correft, or that this fymptom is always con¬ nected with a general fcorbutic diathefis; on the con¬ trary, the above-mentioned author has often feen fcurvy of the gums in perfons quite healthy, in patients af¬ flicted with fcrofula, and other complaints equally re¬ mote in their nature from fcurvy. The primary fymp¬ toms of this complaint are thole of inflammation ; viz. pain, rednefs, and turgefcence. The gums bleed on the flighted: injury ; the tendernefs is firll obfervable on the edges ; the fmooth fkin appears denuded on the latter parts; and often, particularly in the interftices be¬ tween the teeth, there (hoot up irritable granulations. To this ftate ulceration and abforption fupervene : the former procefs is often fo extenfively prefent as to denude all the teeth of each jaw ; more commonly, how'ever, it is confined to one part, at moft to one jaw. It frequent¬ ly happens in this cafe that the alveolar procefs difap- pears by abforption, in which event there is always a very confiderable difcharge of matter from the infide of the gum and alveolar procefs, flowing out in the direc¬ tion of the tooth. In many of thefe cafes, we find that, while the gums are ulcerating in one part, they are fwelling and becoming fpongy in another, and hanging loofe upon the teeth ; and this often takes place when there is no-where any ulceration. At length the teeth become loofe, and in a few years drop out, one after the other, at Ihort intervals, until the perfon is rendered toothlefs. It is from this complaint that many perfons lofe their teeth at a very early period of life. Indeed moft individuals are more or lei's fubjeCt to it ; as the gums, in fome part or another, although there be no iymptoms of the difeafe, are likely to become preterna- turally red, enlarged, and tender. Therefore, whenever a tendency to this difeafe is obferved, great care fhould be taken to apply fuch means as will arreft its pro- grefs. The treatment of fcurvy of the gums confifts in freely lancing them when in the inflamed or fpongy ftate. The ufe of aftringent lotions too is after this of effential fervice. Thefe ftimuli to be varied according to the feelings of the patient. The moft common are infufion of roles with the tinfture of myrrh, decodiion of bark, folutions of alum, arquebufade-water, &c. In fome cafes great benefit is derived from the ufe of fea-water, and Mr. Fox obferves, that he always recommends it to be ufed warm if the gums be tender. When the gums are exceedingly tender, and have any ten¬ dency to ulceration, Mr. Fox recommends wafhing the mouth very frequently with barley- water fweetened with honey. In two or three days, if the forenefs is diminilhed, the lancet is to be cautioufly ufed with the diluted tinfture of myrrh as a walh. When this treatment fails in mak¬ ing the edges of the gums heal, and they hang loofely about the necks of the teeth, Mr. Fox obferves, that Vox,. XIX. No. 1291. much good will be derived from the ufe of a folution of the argentum nitratum. He fays, that, if the difeafe be only partial, the cauftic Ihould be applied with a camel’s- hair pencil dipped in the folution. This remedy is de¬ fcribed as communicating a new action to the gums, and they generally get well in a Ihort time. Indeed, when¬ ever the gums are very full, and difcharge a good deal of offenfive matter, wafhing the mouth with a folution of lunar cauftic is, according to Mr. Fox, a very excellent means of rendering the mouth fweet and comfortable. This remedy, when applied to the fore edges of the gums with a hair-pencil, may be ufed as ftrong as in the pro¬ portion of a dram of the argentum tf> an ounce of diftilled water ; but, if the mouth is to be rinfed with it, not more than one grain of the cauftic fhould be put to two ounces of water, left, by being too ftrong and getting into the throat, it fhould occafion an unpleafant naufea. Perfons, who are often troubled with inflammation of the gums, ought to have them fcarified whenever they become painful, or are more turgid than ufual. By the lofs of a fmall quantity of blood, the affedtion is imme¬ diately relieved, and kept from committing the ravages which have been related. In fcarifying the gums, the lancet fhould be applied longitudinally to thofe parts which are fituated between the teeth, becaufe, if the gums are cut where they cover the fangs, they will flirink in healing, and leave the hecks of the teeth ex- pofed. On the other hand, if the gums are lanced in the angles between the teeth, they will be drawn tighter in healing, and the teeth be eventually ftrengthened. Fox on the Difeafes of the Teeth. In addition to thefe meafures, it will often be neceffary to correct the ftate of the conftitution, when fcorbutic or fcrofulous appearances are prefent. Frequently, too, fecretions from the alimentary canal fhould be procured, for the purpofe of removing irritation extending to the gums, as part of that ftrudture. It is to be remarked alfo, that the free fcarification we have urged above fhould be difpenfed with in fcrofulous cafes, fince, according to the teftimony of Hunter, they do harm in thefe cafes. This author fpeaks favourably of fea-bathing, and rinfing the mouth with fea-water. The next variety, |3, O. extuberans, feems clofely allied with the firll, as a confequence ; unlefs indeed we admit the belief that in this the inflammation is attached to the bony ftrudture. However this be, the tooth affedted in gum-bile is generally found fw’elled, or in advanced cafes abforbed at its fang, while the fubftance of it re¬ mains found. Sometimes, on the other hand, it is fuppofed to originate from a difeafe in the focket, or jaw, which has no connexion with the tooth, and only affedts it fecondarily. Upon drawing fuch teeth, fays Mr. Hunter, they are generally found difeafed at or near the point, being there very rough and irregular, like ul¬ cerating bones. The laft kind of gum-biles may arife altogether from fuch a caufe, the appearance on the fang of the tooth being only an effedl. The fame furgeon has explained, that thefe abfceffes, whether arifing from the teeth or the fockets, always deftroy the alveolar proceffes on that fide where the matter is difcharged, on which account the tooth is ren¬ dered more or lefs loofe. This event may be feen in many Ikulls, and alfo frequently in the living fubjedf ; for, when the alveolar procefs is deftroyed on the outfide of the tooth, if the latter part be moved, the motion may be obferved under the gum all along the fang. When thefe abfceffes have burft through the gums, they often clofe up, and put on the appearance of being healed ; but fuch as difcharge themfelves between the gums and teeth can never heal up, becaufe the gum cannot unite to the tooth. At certain periods, however, the difcharge from them diminiflies, owing to a fubfidence of the fuppura- tion ; but, either expofure to cold, or fome other acci¬ dental caufe, occafioning a frelh inflammation, an in- creafe of the fuppuration is the confequence; and either G g the 112 PATHOLOGY. the old orifice in the gum becomes opened again, or the difcharge by the fide of the tooth is augmented. In the latter cafe, Mr. Hunter believes, that the affeCtion is lefs fevere than in the former, in which frefh ulceration is required for the paflage of the matter. Thus a gum-bile goes on for years, healing and opening alternately ; the effeCt of which is, that the alveolar procefi'es are at length abforbed, and the tooth gets loofer and loofer, till it either drops out, or is extracted. Mod probably, in all fuch cafes, fays Mr. Hunter, the communication between the cavity of the tooth and the jaw is cut off ; yet it keeps in part its lateral attachments, efpecially when the gum grafps the tooth ; but thefe attachments are lefs when the matter paffes between the gum and the tooth ; though fome of them are ftill retained, particularly on the fide oppofite to the paflage for the matter. With regard to the fymptoms of gum-biles, thofe which open through the gum may be diftinguiihed by a fmall riling between the arch of the gum and the attachment of the lip. Upon prelfing the gum at the fide of this point, fome matter will commonly be obferved oozing out at the eminence. This eminence feldom fubfides entirely ; for even when there is no difcharge, and the opening is healed over, a fmall rifing may itill be per¬ ceived, which Ihows that the gum-bile has been there. Such gum-biles as difcharge themfelves between the gum and the tooth are always difcovered by prefling the gum, whereby the matter is forced out, and is feen lying in the angle between the gum and the tooth. A fungus will fometimes Ihoot out of the orifice of a gum-bile, in confequence of a luxuriant difpofition to form granulations on the infide of the abfcefs, and the opening being backward to heal. In this cafe, the tooth aCls as an extraneous body ; and, by the fecretion of matter, the abfcefs is prevented from healing. There is no difference in the treatment of gum-biles, whether they arife from a difeafed tooth, or a difeafe in the locket. When an abfcefs forms round the root of a tooth, the tooth, by lofing its connexion with the other parts, lofes every power of union, as it is not endowed with the power of granulating. Hence it becomes an extraneous body, or at leaft aCts here as one, and that of the worft kind, which, fays Mr. Hunter, it is not in the power of any operation in the machine to get rid of. In this cafe, therefore, the only cure is by the extraction of the tooth ; and, as this is the laft refource, Mr. Hunter obferves, that every thing fliould be done to make the parts as eafy under the difeafe as polfible, fo that this operation may be poftponed. When the abfcefs has burft through the gum, Mr. Hunter advifes us to keep the opening from doling, with a view of preventing future gatherings. He recommends enlarging the opening, and keeping it enlarged till all the infide of the abfcels is Ikinned over, or the aperture in the gum lofes the difpofition to dlofe up. This will in a great meafure prevent any future formation of mat¬ ter, or at lead whatever is formed will find a ready out¬ let, fo that no accumulation can happen. The end of the fang, indeed, will be expofed ; but, under fuch cir- cumftances, it will not be in a worfe fituation than when foaked in matter. Mr. Hunter next remarks, that one method of doing this is to open the gum-biles by a cru¬ cial incifion the full width of the abfcefs, and fill it with lint, which fliould be dipped in lime-water, or a diluted folution of lunar cauftic, made by diflolving one drachm of the cauftic in two ounces of diftilled water; and the wound fliould be dreffed very frequently, as it is with difficulty that the drefling can be kept in. If this is not fufficient to keep the wound open, it may be touched with the lunar cauftic, fo as to produce a flougli ; and the application may be repeated, if found necefl'ary. Some difficulty is experienced in keeping on the dreflings ; but conftant attention will make up for the inconvenience of fituation. Mr. Hunter alfo fpeaks in favour of touch¬ ing the furface of the abfcefs with the lapis fepticus, and keeping the lip from coming into contaCf with the part for one minute, within which fpace of time the cauftic will penetrate to the bottom. The furface of the bile fliould be wiped as dry as poflible, that the cauftic may not do mifchief by fpreading. It has been a practice to extract the tooth, then file off' any difeafed part of it, and immediately replace it. This method has often failed, in confequence of the tooth being introduced into a difeafed jaw ; but occafionally it has fucceeded. When a gum-bile is formed on a back-tooth, the treatment, according to Mr. Hunter, need not be fo nice as when the abfcefs is fituated upon any of the fore¬ teeth, becaufe appearances are then of lefs confequence. Therefore the gum may be flit down upon the fang through its whole length, from the opening of the gum- bile to its edge; which proceeding will preventany future union, while the healing of all the cavity of the abfcefs will prevent any future collection of matter. The wound afterwards refembles the liare-lip. Hence this practice is not advifable when the place of the cut would be much in view, as when the abfcefs is fituated upon any of the fore-teeth. In thefe cafes, when the granulations pro¬ trude from the fmall opening, a cure may be effected in the manner above mentioned, or the granulations may be cut off with a knife or lancet. However, in general, a permanent cure cannot be thus effected, and the gra¬ nulations rife up again. In confequence of bad teeth, excrefcences alfo arife from the gum, near or in contaCt with the teeth which are difeafed. In general, fuch growths may be eafily re¬ moved with a knife, or any other cutting inftrument which may be found moft convenient. They will often rife, in a day or two after the operation, as high as ever; but this newly-generated matter generally foon dies, and the difeafe terminates well. They frequently have fo much of a cancerous appearance as to deter furgeons from meddling with them ; but Mr. Hunter believed, that, when they arife at once from the gum, and appear to be the'only difeafed part, they have no malignant dif¬ pofition. However, this great furgeon had feen them with very broad bafes when the whole could not be re¬ moved, and yet no bad confequences refulted from the partial removal of them. In a few years they often rife again, by which means a great deal of trouble is occa- fioned. The writer of this article has feen a cafe of this nature, in which the extent and rapid growth of the fungus rendered excifion impracticable, very fuccefsfully removed by tearing out, and the life of cauftic. The few remarks we have made on the fubjeCt of dif- eafes of the teeth and gums, clearly indicate the regula¬ tions which fliould be adopted for the prefervation of thefe beautiful ltruCtures; viz. by abolifhing the ufe of all dentifrice capable either of mechanically detriting, or chemically diflolving, the enamel, qs well as of all ali¬ mentary fubftances which have the fame effeCts; but at the fame time of diligently removing, at leaft once a-day, all fordes from the mouth. Perhaps nothing conduces to the fame purpofe more than healthy action of the fto- mach ; for the vifcid ftate of the falivary fecretions are well known when that organ is deranged ; and we may further remark, that fine teeth are moft ufually obferv- able in thofe who are free from gaftric difturbance; and that few animals are fubjeCt to decayed teeth in an equal proportion to our own race. As a popular notion is pre-, valent, that the ufe of fugar is prejudicial to the teeth, it is proper in this place to contradict it as far as regards the circumftance of its diflolving the enamel ; for general de Beaufort ate every day for forty years a pound of fu¬ gar, and lived to the age of feventy. After death, his vifcera were found free from difeafe, and his teeth found. (Anecdotes de Medecine, tom. ii. p. 35.) Plenck put a healthy tooth into fome fyrup diluted with water, and kept it there two months, at the end of which time it was taken out, and found to have undergone no change. (DoCtrina 113 PATHOLOGY. (Doftrina de Morb. Pentium, p. 52.) How far, however, this fubltance may indireftly hurt the teeth, by derang¬ ing the gaftric funftions, may admit of fome difcuffion. Genus II. Ptyalifmus , [from wlow, to fpit.] Diforders affecting the Salivary Glands. This genus contains three fpecies. 1. Ptyalifmus acutus, or Salivation, has three varieties : et, hydrargyratus; (3, fympatheticus ; 7, mellitus. a. Ptyalifmus hydrargyratus. This confifts in an in¬ creased Secretion of faliva from an extreme action of the Salivary glands. As an idiopathic diSeaSe, it is Seldom Seen, and even then not until it hasaffumed the chronic 'form. It more ufually makes its appearance in confe- quence of irritation from mercury. Other fubftances, however, will produce it ; but this is the molt common, and the only one we are acquainted with which increafes this Secretion with certainty and precifion. Formerly the uSe of mercury for the purpofes of Salivation was carried to So great an extent, that frequent floughings and ul¬ cerations of the mouth were the confequence. But, llnce it has been known that the degree of violence with which mercury is puflied is far from increaling its curative effefts, we have not to record So many of thofe frightful appearances. The production of this difeafe is generally the work of the phyfician. With refpeft to the quantity of mercury neceflary to produce it, the greateft variation is obferv- able. While, on the one hand, it is carried into the conftitution without vifible effeft for very long periods, or is carried off by Sweat, purging, & c. on the other, the moll trifling doSes in different conftitutions produce vio¬ lent and alarming effefts in a few days. The inftances in which the patients have been infenflble for long periods to large and frequently-repeated dofes of this medicine, will be familiar to mod of our readers. The oppofite ftate of conftitution is not perhaps So frequently met with ; but even that is Sufficiently common. The uSual quan¬ tity of mercury required is about five grains of the blue pill, which contain a grain of mercury, to be repeated three times a-day ; or, if calomel is employed, a grain night and morning at firft, or two grains at night, guarded with a grain of opium, left it Ihould irritate the bowels, will be a proper dofe. If the ointment is preferred, half a dram of the ftrong mercurial ointment may be rubbed in night and morning. In about a week or ten days, by either plan, the mouth will be Slightly fore in the majo¬ rity of cafes; while, on the contrary, as we have before mentioned, cafes are not uncommon in which two or three Small dofes of mercury have produced copious fa¬ livation. In debilitated habits, three grains of calomel given in the dofe, or one grain on three Succeeding nights, has been found to induce the discharge. It has been brought on by Sprinkling precipitate on a wound ( Hil¬ da n u s ) ; by a mercurial injeftion in a fiftula ; by a mer¬ curial girdle; or by the mercurial ointment employed to kill lice. In thefe cafes, the idiofyncracy of the patient Seems to influence the effeft ; and, therefore, this ftiouid be, if poffible, ascertained before mercury is exhibited in any considerable quantity. It is uSual at prefent to produce this discharge in a very moderate degree; but Some aftion on the gums is neceflary, to (how that the medicine has been introduced into the fyftem. This is particularly the cafe in lues and chronic inflammations of the liver. In other complaints it is lefs effential if the Symptoms disappear. The effec¬ tual relief of thefe is the only certain criterion by which we are taught to leave off’ the medicine; and it will be prudent to continue it for fome time after thefe have dis¬ appeared. Of courfe this is not the proper place to difcufs the ef¬ fefts of mercury, or, generally Speaking, its adminiftra- tion ; but, as far as regards the bringing on of ptyalifm, we cannot help remarking, that, as its continuance is al¬ ways unpleafant, and Sometimes difficult of cure, a greater degree of care is required in its inftitution than the generality of praftitioners think proper to adopt. Under this impreffion, we cannot do better than urge the rules of Dr. Hamilton on this fubjeft ; wliofe advice, however it may be thought by Some to favour of unne- ceffary minutenefs, is nevertheless highly ufeful in many cafes, and has the advantage of erring on the right fide in all. “ The firft precaution to be adopted in this climate du¬ ring a courfe of mercury, is confinement within doors, with a regulated temperature of the apartment. The utility and the neceflity of this precaution muft be So ob¬ vious, that it is unneceffary to expatiate upon the fub¬ jeft. Not that it is meant that the patient fliould be con¬ fined to an ill-ventilated room 5 for, on the contrary, a plentiful Supply of freflr air is of effential utility. While the boldnels with which Mr. Pearfon expoles Such pa¬ tients to cool dry open air may be well Suited to perfons who have been immured in a crowded hofpital with a mercurial atmofphere, it certainly would be moft preju¬ dicial to the better ranks of Society in private practice. “ zdly. The diet ought to confilt of the mildeft poffi¬ ble food, Such as preparations of milk and farinaceous matter, with weak animal mucilages. In ffiort, all (Simu¬ lant food or drink of every description, ought to be molt fcrupuloufly refrained from. “ 3dly. IS the individual be robuft. Sixteen or twenty ounces of blood Should be drawn from the arm before any preparation of mercury be exhibited. Where, from the delicacy of the patient, blood-letting cannot be ad- vifed, confinement within doors a week previous to be¬ ginning the mercury, and during that time one or more dofes of cooling phyfic ought to be taken. “ 4thiy. The mercury mult not be given in Such quan¬ tity, or with Such aftivity, as to produce a Sudden effeft upon the fyftem. This is certainly one of the moft im¬ portant practical improvements, fuggefted by Mr. Aber- nethy and others, and confirmed by the late experiments; for irreparable mifchief was often committed by the hurry with which the fyftem was loaded with mercury. If the other precautions be implicitly adopted, the more (lowly the mercury is adminiltered, the more certainly, and perhaps Speedily, will the primary Sores heal. “ 5thly. Although, in particular cafes, (ome of the more aftive mercurial oxydes may be ufeful, the blue pill or the blue ointment furnilh in general tliefafeft and mildeft preparations of mercury. “ 6thly. Salivation is to be guarded againft by leffening the dole, or fulpending the medicine, whenever the brally tafte in the mouth is perceived. The Same meafures are to be purfued if any irritation of the bowels threatens. “ 7thly. Some vegetable diluent ought to be drunk in large quantities, for thepurpofe principally of preventing the peculiar ftate of the blood, which mercury is So apt to produce. The decoftions of farfaparilla, guaiacum, faffafras, &c. 'anlwer this purpofe; and perhaps they are all equally efficacious, if drank tepid, and in Sufficient quantity. “ Stilly. It is extremely difficult to eftablifli any gene¬ ral rule tor the duration of a mercurial courfe, as that muft be regulated very much by the circumftances of each particular cale. From two to three months may perhaps be Sufficient in the majority of cafes. “ 9thly. The daily ufe of the warm bath, where that can be conveniently commanded, is found particularly beneficial. “ xothly. If any irritable feelings occur wdiile under the influence of mercury, the ufe of the medicine fliould be inftantly fufpended, and the moft aftive mealures for checking the progrefs of Such complaints ought to be carefully adopted. Preparations of camphor, of the fpi- ritus ammonite aromaticus, of opium, of cicuta, &c. are Se¬ verally ufeful, accprding to the circumftances of each cafe. “ uthly. After the mercurial courfe is finilhed, the patient ought to remain within doors for at lealt a fort¬ night, improving the diet, (though ftill abftaining from wine 114 P A T II O wine and ftimulating liquors,) and taking gentle exercife, progrelTively increafing it according to the return of itrengrh. “ Laftly. The flannel and woollen drefs, in which thofe under a courfe of mercury Ihould be, literally fpeaking, encafed, is to be changed daily ; and, befides the ordinary precautions of having thofe articles of drefs well waffied, it is neceffary that they be expofed for at lead twenty- four hours to the open air, and afterwards to the influence of a large fire, before being again ufed.” Salivation is ufed as a curative means in lues, liver- complaints, in fome fevers, &c. in our account of which we (hall take further notice of it. It has been recom¬ mended, moreover, as a cure for pbthifis by Dr. Ruth ; and a cafe was publifted in the 3d volume of the London Medical and Phyfical Journal, ftrongly corroborative of this treatment, by Dr. Peiffer. We may here remark that there is every reafon to fuppofe that cafe, as well as feveral others recorded in fupport of the fame opinion, were not genuine phthifis, but rather that form of pul¬ monary difeafe which fupervenes on difordered (fates of the hepatic fyftem, and in which mercury undoubtedly exerts a falutary influence. With reganl to the treatment of mercurial ptyalifm, it is generally remarked, that, as foon as the mercury ceafes to be adminiftered, the fpitting ceafes of itfelf. At all times, however, this does not fake place ; and accordingly we have many methods recommended by various authors for its removal. Thofe molt in repute are purgative me¬ dicines, opium, and fulphur. If any mercury remains in the fyftem, thefe will fometimes relieve ; but thele medi¬ cines are not all of equal efficacy. Mr. Hunter thinks purgatives ufelefs, and Dr. Parr lias not found them highly beneficial, though he thinks they fometimes lefl'en the difcharge. Opium is highly ufeful, particularly in the form of Dover’s powder. Sulphur is known to lefl'en the activity of mercury out of the body ; and, as it en¬ ters the circulation with little change, it may have the fame effect on the circulating fyftem. But this, like other finely-fpun theories, deceives us in praClice. Sul- phuris by no means highly ufeful in thefe circumftances. Diuretics, which feem to excite what appears to be a vi¬ carious difcharge, have been employed but with little ef¬ fect. We believe every praftitioner, by the means men¬ tioned, has been able to mitigate falivation ; but by no remedies, in every inftance, to conquer it wholly. See Hunter, Swediaur, Bell, and Howard, on the Venereal Difeafe ; Stahl de Salivatione Mercuriali ; Alberti de Hy- drargyrofi ; and Hamilton on the Ufe and Abufe of Mer¬ curial Medicines. As a critical difcharge, falivation is for the moft part falutary, and often terminates the difeafe that excites it. This is frequently the cafe in fevers; and the following inftance is perhaps worth relating. A lady, aged twenty- four, and of a delicate conftitution, was attacked with the typhus in the fpring of 1788, under which (lie gra¬ dually drooped for nearly three weeks. Dr. Good thought her in great danger; but on the twentieth day a fudden and copious ptyalifm fupervened that evidently afforded her confiderable relief. “This continued for upwards of .1 week, the daily fecretion being never lefs than a pint, and twice not lefs than a pint and a quarter. Yet, inftead of adding to her debility, it appeared to give freflt vigour to the fyftem : the digeftive funftion re¬ fumed its office; (he daily improved in (L ength, and, on its ceffation at the above period, was in a (late of conva- lefcence.” We have numerous hiftories in which it has proved equally ferviceable about the acme of ftnall-pox; and the fluid of dropfies is faid to have been frequently d i re¬ charged by this channel. An extraordinary inftance of this is related by Dr. Huxham, in Phil. Tranf. for i7a4~ vol. xxxiii. The patient was a man aged forty, of a (pare bilious habit, who had an attack of jaundice, followed by a paroxyfm of colic, this laft being produced by 3 LOGY. drinking too freely of cider. Among other medicines was given a bolus, containing a fcruple of jalap, eight grains of calomel, and a grain of opium. Copious de¬ jections followed, and a few hours afterwards the pa¬ tient complained of pain and fwelling in the fauces, fpat up a little thick brown faliva, which was foon confider- ably increafed in quantity, of a deep colour, refembling greeniffi bile, though fomewhat thinner. This flux of green and bilious faliva continued for about forty hours, during which time the quantity difcharged amounted to four pints. The colour of the faliva then changed to yellow, like a folution of gamboge, wit., an increafe ra¬ ther than a diminution of the quantity. It continued of this colour for the fpace of forty hours more, after which it gradually became pellucid, and the falivation ceafed as fuddenly as it came on. During the flow of the faliva, the teeth and fauces were as green as if they had been ftained with verdigris, and the teeth retained the fame colour for a fortnight after the ptyalifm had ceafed. The patient had a few years before been fuddenly attacked by a fpontaneous falivation, fo exceffive as to endanger his life. In the prefent inftance, therefore, it is probable that the dofe of calomel co-operated with the peculiarity of the conftitution in exciting the difcharge : but, what¬ ever was its caufe, it proved critical both of the jaun¬ dice and the colic; for, from the moment it took place, the pain of the bowels ceafed, and the greeniffi colour of the (kin began to fubfide, the urine being at the fame time fecreted more abundantly, and of a blackiffi hue. A very remarkable cafe is related in the London Med. and Phyf. Journal, vol. xxx. p. 37, by Dr. Yeats. The fubjeft: was a female, in whom a ptyalifm was excited for the purpofe of improving the date of the menftrual dif¬ charge. This attempt, however, brought on very great derangement of the digeftive organs, manifefted by im¬ mediate rejeftion of every kind of medicine or aliment, by acid galtric fecretion, &c. The cure of this ftate re¬ filled every means fuggefted by the experience of Dr. Yeats, until he again induced ptyalifm, when every un- pleafant fymptom abated, and the patient gradually and perfeftly recovered. Remarkable as this cafe appears, and difficult as it is to trace the mode of curation eftabliffied by the refufcitation of ptyalifm, we perfeftly coincide with Dr. Yeats in attributing the recovery of his patient to that procefs. The reader will meet with fome impor¬ tant remarks on this fubjeft in the Med, Obferv. and En¬ quiries, vol. iii. by Sylvefter and Dobfon, and by Bardfley in the Med. Reports. £. Pt. fympatheticus, or mouth-watering. A watering of the mouth experienced by fome at the fight or fmell of food is an inftance of its production by nervous influence. Its occurrence in fever and other complaints, where it feems to produce very falutary effeCts, (hows that it fome¬ times becomes fpontaneoufly the feat of tranflated or fubftituted difeafe. Mechanical preffure, as is well known, excites very much the aftion of the falivary glands ; as in chewing, fucking, &c. It is on this prin¬ ciple that it has been recommended to roll a marble, or fmall bullet, in the mouth, for the purpofe of afl'uaging third; the mufcular motion neceffarily involved in this aft, eliciting copious falivary fecretion, and confequent moiftening of the fauces. Tobacco likewife, and all other local irritants, are capable of inducing this en- creafed fecretion. y. Pt. mellitus, or fweet fpittle. This is generally connefted with diforder of the ftomach : its remote caufes are probably identical with thofe of Diabetes mel¬ litus. Dr. Good obferves of it, that the fecretion of fw'eet or mawkiffi faliva is not only for the moft part free, but accompanied with naufea, and other fymptoms of indi- geftion : and is probably what Sauvages intends by his firft fpecies, P. naufeofus, or a (aburra nidorofa. It is relieved by magnefiaand other abforbents ; but will often only yield to an emetic, followed by warm ftomachics. It may be neceffary, no doubt, to vary the treatment ac¬ cording 115 PATHOLOGY. cording to the nature of the gaftric difturbance. This affeClion is alfo occafionally fympathetic, as in dentition fometimes occurs, and as a f'equel or crifis to various other afteCtions. 2. Ptyalifraus c'nronicus. When, from the caufes we have detailed, an excited ftate of the falivary glands has continued long, a chronic inflammation is fet up, and al¬ tered and vitiated Hates of the fecretion take place. This naturally induces much derangement of the procefs of digeftion, and hence demands more particular atten¬ tion. In addition to the conftitutional remedies required in the acute ftage of ptyalifm, we are now called upon to adopt the application of topical remedies, for the purpofe of altering the aCtion of the fecernents. Of thefe, acid and aftringent gargles are the moft ufeful. Blifters be¬ hind the ears have alfo been found efficacious. Dr. Robertfon has detailed, in the LondonMedical andPhyflcal Journal, vol. xxxiii. fome cafes fuccefsfully treated by the oxyde of bifmuth. In the London Medical Tran- faCtions, vol. ii. a curious cafe is mentioned, in which a very long-continued and troublefome ptyalifm was cured by chewing dry bread and fwallovving it. 3. Ptyalifmus iners, drivelling or Havering. This confifts in an involuntary and diftreffing flow of faliva from fiuggiffinefs of deglutition or other caufes, without increafed Jecretion. It has three varieties : cc, infantilis ; £, fenilis; 7, moriae. This affection is diftinguiffied from the other fpecies of ptyalifm by the circumftance, that, while in the former increafed fecretion (arifing either from an excitement or dilated Hate of the fecreting veflels) is prefent, in this the redundancy of fluid owes its exiftence to diminijhed ahjbrption, and to the want of that almoft continual deglu¬ tition by which this fecretion is removed from the mouth. The lecond variety is particularly attendant on para¬ lytic patients. This circumftance is probably connected with the ftate of the brain ; an idea which obtains con¬ firmation from the contemplation of the third variety, with which debility of underftanding is thus curioufly connected. To trace the relation which exifts between thefe ftates would form a fubjeCl of much intereft and difficulty. As it does not appear however, that, in the prefent ftate of our knowledge, this affeCtion is under the control of the medical art, we (hall wave all further difcuffion of the lubjeCt. Genus III. jfivfphagia, [from bad or imperfeCt, and Qccy u, to eat orlw’allow.] Pain or obftruCtion in fwallow- ing. This genus includes five fpecies. 1. Dyfphagia conltriCta, or difficulty of fwallowing from permanent diminution of the calibre of the cefophagus. This affeCtion arifes from a thickened ftate of the mucous membrane, from induration of the fame, from its acqui¬ ring a cartilaginous ftrudlure, from offiflcations, excref- cences, fcirrhous or calculous concretions, See. It may be produced likewife by tumors prefling on the canal, when thefe arife from neighbouring parts. Ulcers like¬ wife, or other folutions of continuity, by deftroying the play of the circular fibres, prevent or impede deglutition. Among other caufes, Dr. Parr, in his Medical DiCiion- ary, mentions the concretion of mucus, and fupports it by the teftimony of Hoffman. We need fcarcely obferve, that, from the nature of the cefophageal ftrudlure, this circumftance cannot occur, unlefs indeed the natural le- cretions are very much altered ; an alteration which would impiy previous difeafed action for a long period, and hence is unlikely to be removed by diluents and ni¬ trous powders, as the above-mentioned author has re¬ commended. The cafe in queftion was probably one of the kind deferibed by Dr. Baillie in his work on Morbid Anatomy, in which coagulated lymph was found in great quantity. The obftruCtion of fwallowing is moft fre¬ quently caufed by mechanical injury, as pins ,or other iubftances accidentally introduced. From whichever of thefe numerous caufes impeded Vol. XIX. No. 1291. deglutition may arife, the removal of the caufe itfelf will be the firft indication of cure. Hence, in all cafes where tumors in or around the pharynx exift, the removal or diminution of thofe morbid accumulations rnuft be at¬ tempted. This is, however, no very eafy talk, becaufe, in the firft place, the kind of tumor or excrefcence is feldom to be diferiminated when in the canal ; and thofe which arife externally, as bronchocele, & c. are often dif¬ ficult of cure. In thefe cafes, while we ufe every en¬ deavour to remove the difeafe according to particular in¬ dication, the patient mult be fupported with nourifhing clyfters or with liquid aliment palled into the ftomach by means of a flexible tube. By this contrivance, according to the teftimony of Dr. Good, a lady was fupported for twenty years. Difficult as tumors of the cefophagus are to remove, w’e ffiould not negleCt every probable means of relief ; for fometimes the breaking of an abfeefs and the difeharge of its contents has been of great fervice. In the Hiftory of the Royal Medical Society in Paris for the year 1776, we are told, that a young lady, aged fixteen years, after being troubled for about three months with a fpafmodic cough, began to have a difficulty of fwallowing, which increafed fo fall, that after a very fliort time ffie was in¬ capable of taking any nourifhment by the mouth, fo that, for the fpace of three months, life was fupported folely by clyfters. Mercurial and other frictions were employed without effeCt. At length M. Macquart, reflecting on the cafe, and conjecturing that an eneyfted tumourexifted in the cefophagus, and that it might probably be now in a ftate of fuppuration, he refolved to adminifter fome fubftance, which, by its weight, might occafion a rup¬ ture of the fac. For this purpofe he preferibed an ounce of crude mercury, mixed with the yolk of eggs, to be fwallowed every three hours. This remedy was taken, and the patient, foon after flie had fwallowed the fecond dofe, brought up a confiderable quantity of pus. From this moment ffie was able to fwallow broth, and by pro¬ per care recovered. An emetic, in cafes when complete itoppage does not happen, might be preferibed with equal advantage. According to Dr. Parr, when fcrofulous in¬ durations happen about the cefophagus, the ungt. hy- drargyri, rubbed on the neck over the induration, or fmall dofes of calomel, have often been of Angular effi¬ cacy, efpecially if ufed early after the attack of the dif- order. If the cafe is of more confiderable duration, he thinks the mercurials ffiould be given, fo as to excite and fupport a moderate ptyalifm for fome time. Many are the contrivances for removing foreign bodies flicking in the paflage to the ftomach ; but it would often be better to leave the cafe to nature, than to irritate fo tender a part, which muft be the effeCt of fuch attempts. If the fubftance'can be reached with the fingers, or with the forceps, the extraction is eafy. When pins, fiffi- bones, or fimilar bodies, flick acrofs the gullet, fome re¬ commend a wire with its end turned up like a hook, to be pafled below thefe bodies, and then turned fo as to bring them up. Pins, and other (harp bodies, when they have ftuck. in the throat, have been returned by fwallowinga piece of tough meat tied to a ftrong thread, and then pulled up again. If the detained body may more fafely be pulhed down, the probang is a ufeful in- ftrument. It hath frequently happened, that, though indigeftible bodies have been fwallowed, no inconveni¬ ence hath arifen from them. (See Lond. Med. Tranf. vol. iii. and Med. Mufeum, vol. ii.) If the bodies cannot be eafily moved up or down, endeavours Ihould not be con¬ tinued long, left inflammation come on. If the patient can fwallow, a large draught of water may be taken, a pradfice the more neceflary if the fubftance wedged in poflefs any great degree of folubility; or, if he cannot fwallow, an affiftant may injeCt fome fluid into the gullet, W'hich will fometimes loofen the impacted body. When thefe endeavours fail, the patient muft be treated as if labouring under an inflammatory difeafe; and the fame H h treatment 116 PATHOLOGY. treatment will be required if an inflammation take place 5n the part, after the obftruCting body is removed. A proper degree of agitation has fometimes fucceeded in removing the obftruCting body better than inftruments. Thus a blow on the back hath often forced up a fubftance that ftuck in the gullet or windpipe. Pins, which have lluck in the gullet, have been difcharged by riding on a liorfe or in a carriage. In the London Medical Obfervations and Inquiries, vol. iii. is an account of a finall fibre of a feather being fwallowed, and extradited by means of a probang with a thread or two palling from one end to the other, and faftened to the fponges which w'ere connected with each end of this inftrument. For fome more complicated methods of extracting thefe fubltances, fee the article Surgery. Independently of the caufes juft mentioned, Dr. Baillie has obferved, that the cefophagus is liable to ftric- ture, produced by the contraction of its mufcular fibres at fome particular part. This difeafe is mod common in women whofe conftitutions are delicate, and much fub- jeCt to nervous influence. When fuch a difeafe is exa¬ mined in the dead body, the cefophagus is found to be’ more or lefs contracted in fome part of it, and it feels harder than ufual, as all mufcles do in a contracted ftate. There is no appearance of difeafed ftruCture ufually com¬ bined with it ; yet this contraction might lay the founda¬ tion of a permanent and even a fatal difeafe. The muf- cularfibres of the cefophagus might fo piefs on the inner membrane, as to excite inflammation in it, which might advance to fuppuration, and would molt probably termi¬ nate fatally. A very unufual ftriCture of the cefophagus has been noticed by the fame author. It confilted in its inner mem¬ brane being puckered together, foas to form a narrownefs of the canal at a particular part. The canal at that part was fo narrow, as hardly to allow a common garden-pea to pafs. There w'as no appearance, however, of difeafed ftruCture in the inner membrane which was fo contracted, and the mufcular part of the cefophagus furrounding it was perfectly found. This difeafe was very flow in its progrefs; for the perfon in whom it took place had been for many years affeCted with a difficulty of fwallowing, and could only fwallow fubftances of extremely finall fize. Thefe cafes have been much relieved by an attention to the ftate of the ftomach and inteftines, though not fo much fo as in the fpafmodic affeCtions we flrall have oc- cafion prefently to notice. But we (hall fubjoin a cafe wherein a cure was very happily performed by mechani¬ cal means. It was communicated by Dr. Stevenfon, of Kegworth, to the Medical and Phyfical Journal, vol. viii. “ Mrs. Wagdin, Trent Lock, Derbyfliire, the fubjeCt of the fubfequent communication, is forty years of age, of a thin fpare habit, and irritable temperament. She dates the origin of her complaints from a violent attack of cynanche maligna near twelve years ago, to the contagion of w'hich (lie was expofed alrnoft immediately after her recovery from a fevere parturition. The moll prominent features of her diforderfrom that period till the expiration of more than three years, were a flight though progreffive- ly-increafed difficulty of fwallowing, accompanied with fome degree of forenefs, and an augmentation of the lalival excretion. With a view' to the palliation of thefe fymptoms, (lie was directed to have occafional recourfe to aperients, leeches, blifters, and gargles. By this time, however, the difficulty of deglutition had become fo alarmingly exafperated, that (he was no longer capable of fwallowing folids, even of the magnitude of a pea. In this fituation (lie put herfelf under the direction of Dr. Smith, late of Nottingham, who prefcribed mercurials. A moft fevere falivation was the confequence, under which ihe laboured for the protrafted (pace of three months. By this method the fymptoms were fo ccnfider- ably alleviated, that (lie was capable once more of fwal¬ lowing foft and well-comminuted folids. But, though thus refcued from her impending fate, the remedy was productive of effeCts no lefs formidable. I allude to ex- ceffive debility, frequent fyncope on the leaft motion, colliquative fweats, her fyftem being greatly emaciated, and a prey to hyfterical paroxyfms. By the aid of proper dietetical management, as the complaint it was vainly hoped was fubdued, her attendants flattered themfelves (lie might (till furvive even this fevere conteft. Alas! no fooner were her drooping fpirits reanimated by the fenfible acquifition of renovated vigour, than the fond expectations (he had cheriflied became deprefled by a vilible return of her former impediment to fwallowing. “ During the laft (even years, (he found herfelf reduced to the fad neceftity of fupporting a miferable exiftence by means of liquid aliment, fuch as foups, milk, &c. I faw her for the firft time in the beginning of OCtober, 1801. She had then a dejeCted emaciated appearance, a quick pulfe and other heCtic fymptoms, and was harraffed by an alrnoft inceflant ptyalifm, more particularly urgent during the earlier part of the day, at which time (he was always hoarfe. The breathing was much incom¬ moded when (lie reclined on a fofa or bed, which con¬ curred with the other fymptoms in rendering her nights very reftiefs. Her bowels were habitually inactive. There was not any external tumefaCtion of the thyroid gland, nor could the obftruCted part be obferved by in- lpeCting the fauces. “ Dyfphagia, in this inveterate ftage, has I believe hi¬ therto alrnoft invariably bidden defiance to the beft-direCted medical expedients ; and the Angularity of the cafe will, I truft, be deemed a fulficient apology for; the minutenefs of its defcription. I propofed to her, as a dernier refort, to have recourfe to mechanical dilatation, a practice none of the faculty had before even fuggefted. Senfible that, if not fpeedily relieved, (lie muft fall a victim to this relent- lefs difeafe, (lie agreed to fubmit implicitly to any plan from the adoption of which the fmalleft profpeCt offuccefs might rationally be anticipated. “ I firft cautioufly introduced a common bougie into the lower part of the pharynx. In this place, a powerful refiftance that occurred, and which occafioned my inftru¬ ment, on the application of fomewhat forcible preflure, to bend in various directions, feemed to confij-m my< theory of the nature of the difeafe. Thus foiled, I ven¬ tured to fubftitute a finall probang copioully charged with oil. It was not without fteady and continued efforts that this operation was made to dilate the ftriCture. After having overcome this obftacle, the inftrument defcended without much difficulty till it reached, I fuppofed, the lower portion of the celophagus near the cardia, when a fecond impediment announced the exiftence of another ftriCture. The fame meafures however at length availed in enabling the probang alfo to force a paflage through this contracted part, when it fuddeniy pafi’ed into the ftomach. The inftrument having been deliberately with¬ drawn, as foon as Mrs. W. had fomewhat recovered from the irritation and fatigue produced by this, I gave her fome gruel which ftood ready, in order that (he might af- certain, by fipping leifurely a fmall quantity, whether any benefit had accrued from the operation. Upon at¬ tempting to fwallow, (lie found the former impediment re¬ moved, and continued drinking till (lie had confumed at leaft half a pint of the liquid with the greateft facility as to the power of deglutition, though of courfe fome fore¬ nefs muft have exilted. Apprehending that the paflage would not, by the fmall inftrument employed, be fufficiently dilated to admit of the ready ingurgitation of Folids, the operation was repeated with a larger inftrument three fucceflive times, a few days being fuffered to intervene between each, in order that the topical pain might be al¬ layed by the exhibition of oily linCtufes and aperients, and by fomentations. The fourth operation enabled her to fwallow folids without experiencing the fmalleft in¬ convenience, a faculty (lie (till continues to exercife in its fulleft extents “As 4 117 PATHOLOGY. tc As a further teftimony of the efficacy of mechanical means in the radical cure of this tremendous difeaie, permit me (hortly to add, that the only daughter of the above-mentioned lady, aged twelve years, had from her earlieft infancy, indeed from her birth, laboured under Dyfphagia conftriCta. Her conftitution partakes much of the nervous irritability of her mother. The want of fubftantial food (for her exiftence had been fupported by the fuCtion of liquid aliment alone) tended obvioufiy to retard the phyfical evolution of her fyftem. The complete fuccefs which had crowned my efforts in the cafe of Mrs. W. naturally created an anxious wilh in the pa¬ rents to have the fame means reforted to in the prefent inftance ; of the abi'olute neceffity of which my intelli¬ gent little patient was fully fatisfied, and readily con¬ tented to undergo the operation, from the. fanguine ex¬ pectation of deriving equal benefit. It is with fentiments of the greateft fatisfaClion I am authorifed to (late, that the expedient has proved altogether falutary and effica¬ cious. The texture of her body, which previous to the operation had ever been extremely delicate, has acquired a wonderful degree of renovated vigour ; and her fpirits, formerly fubjeCl to great depreffion, have obtained fuch a healthy flow, that ihe can now engage in juvenile amufe- ments with the greateft cheerfulnefs and vivacity.” 2. Dyfphagia atonica, or the difficulty of fwallowing from debility of the mufcles concerned in that aCf, is perhaps chiefly diftinguifhed from the other fpecies of this genus by the circumftances, that the obftruCtion f'eems continual, thus different from the fpafmodic ; and that folids are more eafily fwallowed than liquids, which does not obtain in the firlt fpecies noticed. It is often fympathetic of a morbidly-diftended ftate of the mufcu- lar coat of the llomach, dependent on the interrup¬ tion of nervous influence. If even idiopathic, it ftiould be combated by gentle ftimulants, among which bitters perhaps hold the inoft favoured rank. The moft inte- refting cafe in illuftration of this difeafe with which u'e are acquainted, was publifhed in the 3d volume of the Medical Obfervations. The part was preferved in Dr. Hunter’s collection. The pharynx was, in the cafe in queftion, dilated at its lower extremity, into a pouch of confiderable fize, which palled behind the cefophagus. This pouch began to be formed in confequence of a cherry-ftone having relied there forfome time, which had made a kind of bed for itfelf. It remained in that fitu- ation for three days, and then was brought up by a vio¬ lent fit of coughing. A part of the food always refted afterwards in the cavity made by the cherry-ftone, by which it was gradually enlarged. At length, in the courfe of about five years, the cavity was enlarged into a bag of a confiderable fize, fufficient to contain feveral ounces of fluid. This bag paffed down a good way be¬ hind the cefophagus, and the cefophagus neceffarily ac¬ quired a valvular communication with it. In proportion as the bag enlarged, this valvular communication would become more and more complete, till at length every kind of food muft have refted in the bag, and could not , pafs into the cefophagus. In this way the perfon was de- llroyed. The lower end of the pharynx is, perhaps, the only part of the canal where fuch an accident could hap¬ pen. The pharynx is not contracted gradually, fo as to lofe itfelf infenfibly in the cefophagus, but contrails itfelf rather fuddenly at the lower end. Hence a little recefs is formed, in which an extraneous body may occafionally reft. This is neceffarily at the pofterior part, fo that, if the recefs lhould be enlarged into a cavity, it muft pafs behind the cefophagus. Blifters have been found of ufe in the paralytic ftate of the mufcular fibres of the cefophagus; and electricity has been found fuccefsful, with the occaflonal ftimulus of the probang. The latter means we ffiould ftrongly recom¬ mend. 3. Dyfphagia globofa, the globus hyftericus of Darwin, and the nervous quinfey of Heberden, is a difficulty of fwallowing from wind in the ftomach, fpafmodically com- preffed into the feeling of a ball afcending into the cefo¬ phagus, and producing a fenfe of ftrangulation. Irrita¬ tion of the nerves appears to be always conceded with it. This may be produced, in its firft origin, by the many and various caufes acting on the nervous extremi¬ ties. In the womb and the alimentary canal, the rnajo- rity of thefe caufes are applied ; while in many inftances the brain itfelf is primarily and immediately aCted on by mental emotion, and propagates through the nervous fyftem its difturbed ftate. According, then, to the ftruc- ture from the difeafed aCtion of which this phenomenon is derived, it is accompanied by the fymptoms peculiar to diforders of that ftruCture. Hence the variety of appear¬ ances conneCted with this difeafe bid defiance to arrange¬ ment, and finuilate, in their proteiform and varying cha¬ racter, many of the moft ferious maladies ; and hence our plan of cure muft vary according as the ftomach, the brain, or the uterine fyftem, is primarily affeCted. As far, however, as regards the globus hyftericus itfelf, we cannot confider it as any thing but a fymptom of the irritation before delcribed. We give oumolologift’s own reafon for inferting it, which it will be feen does not at all impugn our opinion. He fays; “This (Dyfphagia globofa) is by no means a mere fymptom of hyfteria, as is often fuppofed ; for it as frequently occurs under the influence of various paffions, as grief, fear, and anger; and is a frequent attendant upon the hypochondriacal diathefis. It is, however, for the moft part, a fympathetic affeCtion, concatenating with the ftate of the ftomach.” In fpeaking of Dyfpepfia and Hylteria, we (hall detail this fubjeft in full : for the prefent we may remark, that, for the removal of the mere fymptom, ftimulants of the fto¬ mach are the moft appropriate palliatives. 4. Dyfphagia uvulofa, or fwallowing impeded by elon¬ gation of the uvula. This may arife from Ample relax¬ ation, from inflammation, or ulceration. It is attended with uneafinefs and difficulty in fwallowing, cough, ,nau- fea, commonly a continual fpitting, (ometimes a difficulty of breathing, and a Hammering or faulty articulation. There are two varieties, differing as they arife from in¬ flammation or from relaxation. In the firft, the uvula is fwelled, hot, acutely painful, of a red or livid colour, and falls down in an altered form. Sometimes fuppuration comes on, and the difficulty both of fwallowing and breathing is more confiderable than in the fubfequent va¬ riety. When this complaint is very violent, there is ap¬ parent danger of ftrangulation. It is cured by bleeding and purging ; gargling with fubaftringent liquids, and fometimes lcarification. In the feconcl variety, the uvula, preferving its natural colour, is relaxed, elongated, pale, or cedematous. It is remarkable that, on fome occafions, the irritation arifing from this elongation of the uvula is only felt when the mucous membrane of the ftomach and fauces is in an irritable ftate. A medical man applied to an eminent leCturer on furgery for the purpofe of having a portion of the uvula taken off. The leCturer, who had on (ome former cafe remarked the faCt juft noticed, eluded the performance of the operation for fome days, and during that time directed opening medicines, & c. to be taken ; the confequence of which was, that the patient felt in a little while no inconvenience from his elongated uvula, al¬ though on examination no diminution of its fize was ap¬ parent. The treatment of the relaxed uvula confifts in the ufe of (limulating and aftringent gargles, and trie correction of morbid Hates of the mucous membrane of the alimentary canal. When thefe meafures are unfuc- cefsful, the extirpation of a portion of the uvula is advif- able ; for which, fee Surgery. - 5. Dyfphagia linguofa, fwallowing obftruCted or trou- blefome from magnitude or protrulion of the tongue. This fpecies has two varieties : a, exertoria ; (3, ranula. In a. exertoria, the tongue is protruded, often with enlargement of its fubftance. As an idiopathic and du¬ rable PATHOLOGY. 118 rableaffeftion, it is manifefted moil frequently in children. It happens fometimes immediately after birth ; at others in the firft years of infancy . In both cafes this deformity, be it from birth or accidental, degenerates gradually, when it is not remedied in its beginning, into an habi¬ tual difeafe, which increafes with age; and many have been afflifted with this deformity for life. An author of the fixth century, Gafpar Peucer, is the firft who has laid he had feen children come into the world with the tongue out of the mouth, and “hanging on the chin, like that of a calf recently (lain.” Such is his exprefiion. He confidered this vicious conformation as a phenome¬ non, in fome meafure foreign to the art ; as an incurable monfirofity. The fame cafe has been obferved, with a little more exaftnefs, by Zacchias; this phyfician fpeaks of having feen, in 1628, at Rome, a new-born child, very Jtrong and well formed, who had the tongue out of the mouth, the length at lead of three fingers breadth ; it was a little wider and a little thicker than it ufually is at that age; when the child moved it, and drew it in, one could judge how much it exceeded the opening of the mouth. Neverthelefs, it fucked pretty well, provided the nurfe’s nipple was large and elongated ; for it could not execute the fame fundtion with another nurfe, whofe nipple was (hort and thin. Arrived at the age of about fourteen months, it ate and drank pretty freely, although it had, night and day, a portion of the tongue out of the mouth ; it began even to pronounce fome words, when it died, without Zacchias having known the caufeofits death. The firft appearance of the difeafe is generally loon after birth, though inftances (fee the Memoir of Citizen Laflus in the firft volume of the National Inftitute of Science and Arts in France) are not wanting to fhow that the difeafe has exifted before birth. In either cafe, however, the point of the tongue tumefies, is prolonged by little and little out of the mouth, till it is found ex¬ tending even upon the chin. Suffering the child to fuck much increafes this elongation ; and, in proportion as the tongue extends and tumefies, it draws with it, by its weight, the os hyoides and the fuperior part of the la¬ rynx, which contributes to render deglutition ftill more difficult. The continual and very-abundant effufion of faliva, which is no longer retained in the mouth, induces third and drynefs of the throat; the incifive and canine teeth of the lower jaw are thrown forward, and partly quit their alveoli ; the tongue, rubbing againft thefe dif- placed and worn teeth, excoriates and bleeds ; the lower jaw always hangs down, and projefts a little forward ; the under lip reverfes, and projefts ; the fuperior edge of the lower jaw is hollowed by degrees in its middle, de¬ prived at length of teeth by the preflure and motion of the tongue, which forms there a kind of furrow to lodge itfelf ; in fine, this organ, at times more, at others lefs, tumefied, hangs conftantly out of the mouth. Such are the fymptoms which charafterife this difeafe when it is inveterate ; at the fame time, it does not abfolutely pre¬ vent f'peech and deglutition ; but the found of the voice is harlli, and deglutition is always more or lefs reftrifted. The firft attempts which were made to cure this difeafe were by amputating the protruded part of the tongue; and the fear of haemorrhage alone reftrained the hands of the furgeons of the fifteenth century. It feems that we have no occafion for this violent praftice ; for it has been Ibown by Laflus, in the Memoir above mentioned, on the deareft grounds, that, in nine cafes out of ten, the pro¬ truded tongue is reduceable by gradual prelfure, and that a bandage fo placed as to keep the mouth fliut will gene¬ rally be fufficient to cure the difeafe. This, however, •can only apply to thole cafes in which fimple congeftion or inflammation is prefent, in confequence of the return of blood beiiig prevented by the unnatural pofition of .the organ. Of courfe, when degenerations of ftrufture have occurred, the morbid enlargements will require the application of ligatures or extirpation with the knife. See ■Surgery. |3. D. ranula, is an intumefcence under the tongue, named from its fituation in the vense raninas, or perhaps from its altering the voice of the patient. This tumour is feated on either fide of the fraenutn. It is round, of a greyifh colour like an hydatid, foft, compref- fible, indolent, and, in the early ftage, almoft tranfparent. At firft it is of about the fame fize as a nut or a cherry ; but by degrees its volume becomes much more confider- able. This alfo is very frequently met with in young children : its occurrence in adults is more uncommon. It confifts of a fucceffive dilatation of the excretory tube of the fubmaxillary or elfe of the fublingual gland, the orifice of which duft is by fome caufe or another flopped up, or obliterated ; fo that the confined faliva accumu¬ lates, becomes vifcid, and ceafes to flow in the ufual manner. In proportion as the ranula increafes, the inci¬ pient ftate of it having been neglefted, its enlarged fize raifes up the tongue, and forces it backward ; the confe¬ quence of which is, that maftication, deglutition, and refpiration, are obftrufted. The voice becomes indif- tinft and hoarfe ; the motion of the tongue is reftrained : it cannot be put out of the mouth. By degrees, the in- cifor and canine teeth of the lower jaw are loofened; the layer of mufcles, compofing the lower parietes of the mouth, is deprefled; and the dwelling, having attained a confiderable fize, makes a very manifeft prominence be¬ neath the chin. In this advanced ftage, that is to fay, when it has exifted ten or twelve years, as praftitioners occafionally fee inftances of, the appearance of the fwell- ing is quite altered from wdiat it originally was. The tumour is now hard, elaltic, painful, and ulcerated : it is as large as a turkey’s egg, and not fituated at the fide of thefrumum, but anteriorly under the tongue, to which it is clofely adherent. The mouth emits a very fetid fmell ; and the breathing is fo much obftrufted, that the patient, through fear of fuffocating, is obliged to lie with his mouth wide open, when he goes to fleep. While a ranula is recent, the fluid which it contains is a vifcid faliva, refembling the white of egg, but fome- times of rather a yellow colour. In time it is gradually changed, becoming turbid and puriform ; and, in certain inftances, foft, friable, greyifh, concretions, from the fize of a pea to that of an almond, commonly called falivary calculi, are found in the kind of cylt, which is produced by the dilatation of the falivary duft. Thefe calculi ef- fentially conlift of a large proportion of the phofphate of lime, united with a mucilaginous fubftance. The tumour is often of a fcrofulous kind, and con¬ tains a thick purulent matter. It has been ftyled a hyda¬ tid, and is laid by Siebold to be an expanlion of Whar¬ ton’s duft. When it grows fuddenly, both the fpeech and fwallowing are impeded, with much pain ; but it ge¬ nerally increafes gradually, and its effefts are not violent. Inftances, it is laid, have occurred of thefe tumours de¬ generating into cancers; but this is highly improbable. They are with great difficulty difperfed or brought to fuppuration, and generally require the knife for their removal. And indeed it has been afferted on refpeftable authority, that a ranula, whether recent or inveterate, can¬ not be cured except by a furgical operation. SeeSuRGERY. The fpecies is found occafionally as a fymptom in bron- chccele and other caufes of external preflure. Genus IV. DipJ'afis, [from to be thirfty.] Mor¬ bid thirft ; the defire for drinking exceflive or impaired. This genus contains two fpecies. 1. Dipfofis avens, conftant thirft with acidity of the fauces. This fpecies is generally found in fevers, fluxes, dropfy, &c. Many cafes are on record in which this af- feftion has reached an aftonifhing height. There are fome authentic records which feem to fhow that it is an idiopathic difeafe. See the London Medical Journal, vol. iii. a cafe by Dr. Dyce; and vol. iv. of the fame work, the cafes of Dr. Domeier and Tuaam Peaal. In thefe, aridity of the fauces and pharynx, the probable 4. caufe 119 PATHOLOG Y. caufe of thirft, was prefent, excepting the Jail, almoft with¬ out conftitutional difturbance. The heft treatment appears to be to evacuate the bowels, and the ufeof mineral acids. Of courfe, when the difeale is traceable, and we have little doubt that it is fo in all, to exceflive depletion by fweat, urine, &c. to nervous de¬ rangement, inflammation of the ftomach, or any other difeafed flate, the correflion of that ftate demands our firft confideration. For an allonifhing cafe, in which two hundred pints of wine, and the fame of water, were drunk daily, fee the Eph. Nat. Cur. cent. vii. and for another, in which eighty tnealures of liquid were taken-in daily, fee Binninger in the Adi. Helvet. vii. p. 16. z. Dipfolis expers, or conftant want of thirft. Cullen was of opinion, that this always indicated an aftedlion of the fenforium commune. Sauvages, however, relates two cafes of patients in whom it formed an original difeafe: the one a learned and excellent member of the academy of Touloufe, who never thirfted, and pafi'ed whole months without drinking inlhehotteft part of the furnmer ; the other a woman, who for forty days abftained altogether from drinking, not having had the fmalleft defire, and who was neverthelefs of a warm and irafcible tempera¬ ment. See another cafe that continued for fome years, in theEphem. Nat. Cur. cent. v. and vi. Genus V. Limofis, [from hunger.] Morbid Ap¬ petite; 5. e. exceflive or depraved. The following are the feven fpecies, with their varieties. i. Limofis avens, infatiable craving for food. We have three varieties of this fpecies. a. L. fyncoptica, from a feeling of faintnefs and inani¬ tion. This diforder, we believe, is feldom idiopathic: it more frequently depends on very general gaftric difturb¬ ance, and is certainly connected with deficient adlion of the abforbents. In the Phil. Tranf. vol. xliii. 1745, >s a Angular cafe related by Dr. Mortimer, of a boy twelve years old, who, from a feeling of inanition, had fo ftrong a craving, that he would gnaw his own flefh when not fupplied with food. When awake, he wasconftantly de¬ vouring, though whatever he fwallowed was foon after¬ wards reje&ed. The food given him confided of bread, meat, beer, milk, water, butter, cheefe, fugar, treacle, puddings, pies, fruits, broth, potatoes; and of thefe he fwallowed in fix fucceflive days 384^. 2 oz. avoirdupois, being 64lbs. a-day on an average. The difeafe conti¬ nued for a-year. It is occafionally produced by worms. See a curious cafe of Dr. Burroughs, Phil. Tranf. xxii. 1700 ; in which the patient from this aftedlion was rendered capable of devouring an ordinary leg of mutton at a meal for feve- ral days .together, and fed greedily alfo on fow-thiftles and other coarfe plants. Voracity is, however, by no means an unfrequent fymptom in worms. |3. L. lielluonum, from habitual indulgence in large and frequent meals. Habit, induced by idlenefs, is undoubt¬ edly the moft frequent caufe of gluttony. The unoccu¬ pied perfon perpetually eats, unlefs difeafe impedes this fenfual gratification. Sometimes, however, it feems that an idiolyncracy of a peculiar nature difpofes to exceflive appetite. In a cafe we (hall prefently quote, not only the father, but nine fons, were remarkable for the vora- cioufnefs of their appetite. This aftedlion can fcarcely be called a difeafe; for, without entering into any dif- cuflion on the caufe of hunger, we may remark that that fenfation evidently depends on fome adlionof the ftomach. Whatever that may be, if it is increafed without pain or derangement of the digeftive or any other function, it is evident that we have no more reafon for calling this a difeafe than the great ftrength which we remark in fome men, and which evidently depends on exceflive power of the mufcles. Hence it appears how abfurd thofe attempts muft be which have been made to remove this idiofyn- cracy by acids, opium, &c. in a word by any treatment Vo L. XIX. No. 1291. but the moral. The unfortunate individuals afflicted with this propenfity arefeldom fo robuftas thofe of more moderate appetite ; and they feldom, according to the tefi- timony of M. Perc}-, live beyond the age of forty years. In moft of the cafes on record, the flcin appears to be the part whence the furplus of provifion is thrown off; the itools and urine being commonly in the ordinary propor¬ tion. It would be improper, in a work of this fort, to pafs over the moft remarkable cafe we are acquainted with ; although, from its frequent quotation, it is probably known to. moft of our medical readers. The cafe is that of , the famous Turare, who was known to all Paris, and who died at Verfailles about the year 1800, at the age of twenty-fix years. M. le Baron Percy, who favv Tarare, and who made fome inveftigations re- fpedling this Angular perfonage, has given us the hiftory of him, in a very curious Memoir on Polyphagy. At feventeen years of age, Tarare weighed only one hundred pounds ; and was already able to eat, in twenty-four hours, a quarter of a bullock of that weight. Having left his parents when very young, (he was of the environs of Lyons,) fometimes begging, fometimes Healing, to obtain fubfiftence, he attached himfelf to one of the mountebank (hows on the boulevards. One time, on the ftage, he defied the public to fatiate him; and ate in a few minutes a pannier-full of apples, furniftied by one of the fpeftators ; he fwallowed flints, corks, and all that was prelented to him. At the commencement of the war Tarare entered into the army ; he ferved all the young men in eafy circumftances in the company, did all their jobs for them, and ate up the rations they left for him. Famine neverthelefs gained upon him ; he fell fick, and was taken to the military hofpital at Soultz. On the day of his entry he received a quadruple allowance : he de¬ voured the food refufed by the other patients, and the fcraps about the kitchen ; but his hunger could not thus be appeafed. He got into the apothecary’s room, and there ate the poultices, and every thing he could feize. “ Let a perfon imagine,” fays M. Percy, “all that domeftic and wild animals, the moft filthy and ravenous, are capa¬ ble of devouring; and they may form fome idea of the appetite, as well as the wants, of Tarare.” He would eat dogs and cats. One day, in the prefence of the chief phyfician of the army, Dr. Lorence, he feized by the neck and paws a large living car, tore open its belly with his teeth, fucked its blood, and devoured it, leaving no part of it but the bare fkeleton ; half an hour afterwards he threw up the hairs of the cat, juft as birds of prey and other carnivorous animals do. Tarare liked the fleflt of ferpents ; he managed them familiarly, and ate alive the largeft fnakes, without leaving any part of them. He fwallowed a large eel alive, without chewing it ; but we thought we perceived him crulh its head between his teeth. He ate, in a few inftants, the dinner prepared for fifteen German labourers: this repaft was ccmpofed of four bowls of curdled milk, and two enormous hard pud¬ dings. After this, the belly of Tarare, commonly lank and wrinkled, was diftended like a- balloon : he went away, and flept until the next day, and was not incom¬ moded by it. M. Comville, the furgeon-major of the hofpital where Tarare then was, made him fwallow a wmoden cafe, enclofing a ftieet of white paper : he voided it the following day by the anus, and the paper was un¬ injured. The general-in-chief had him brought before him ; and, after having devoured in his prefence nearly thirty pounds of raw liver and lights, Tarare again fwallowed the wooden cafe, in which was placed a letter to a French officer, who was a prifoner to the enemy. Tarare fet out, was taken, flogged, imprifoned ; voided the wooden cafe, which he had retained thirty hours, and had the addrefs to fwallow it again, to conceal the know¬ ledge of its contents from the enemy. They tried to cure him of this infatiable hunger, by the I i ufe 120 PATHO uie of acids, preparations of opium, and pills of tobacco; but nothing diminifhed his appetite and his gluttony. He went about the flaughter-houfes and bye-places, to difpute with dogs and wolves the mod difgufting ali¬ ments. The fervants of the hofpital furprifed him drink¬ ing the blood of patients who had been bled, and in the dead-room devouring the bodies. A child fourteen months old difappeared fuddenly; fearful fufpicion.s fell on Tarare ; they drove him from the hofpital. M. Percy loll fight of him for four years : at the end of this time he faw Tarare at the civil hofpital at Verfailles, where he was perifhing in a tabid Hate. This difeafe had put a If op to his gluttonous appetite. He at length died in a Hale of confumption, and worn out by a purulent and fetid diarrhoea, which announced a general fuppurntion of the vifcera of the abdominal cavity. His body, as foon as he was dead, became a prey to an horrible corruption. The entrails were putrefied, confounded together, and immerfed in pus : the liver was excefiively large, void of confidence, and in a putrefcent Hate; the gall-bladder was of confiderable magnitude; the ilomach, in a lax ftate, and having ulcerated patches difperfed about it, covered almoft the whole of the abdominal region. The flerlch of the body was fo infupportable, that M. Telfier, chief furgeon of the hofpital, could not carry his invelti- gation to any further extent. Tarare was of a middle-fized ftature ; his habit of body was weak and flender ; he was not of a ferocious l'pirit; his look was timid; the little hair he had preferved, al¬ though very young, was very fair, and extremely fine. His cheeks were fallow, and furrowed by long and deep wrinkles : on diftending them, lie could hold in them as many as a dozen eggs or apples. His mouth was very large ; he had hardly any lips ; he had all his teeth ; the molares were much worn, and the colour of their enamel ftreaked like marble ; the fpace between the jaws, when they were fully feparated, meafured about four inches : in this ftate, with the head inclined backwards, the mouth and cefophagus formed a reCtilinear canal, into which a cylinder of a foot in circumference could be in¬ troduced without touching the palate. Tarare, fays M. Percy, was conftantly covered with fweat ; and from his body, always burning hot, a vapour arofe, fenfible to the fight, and (till more fo to the fmell. He often ftank to fuch a degree, that he could not be endured within the diftance of twenty paces. He was fubjeCt to a flux from the bowels ; and his dejections were fetid beyond all con¬ ception. When he had not eaten copioufly within a fhort time, the (kin of his belly would wrap almoft round his bod}^. When he was well fatiated with food, the vapour from his body increafed, his cheeks and his eyes became of a vivid red ; a brutal fomnolence, and a fort of hebi- tude, came over him while he digefted. He was in this ftate troubled with noify belchings ; and made, in moving his jaw, fome motions like thole of deglutition. M. Percy never faw in him any figns of rumination. Tarare was almoft devoid of force and of ideas. When he had eaten to a moderate extent, and his hunger only ap- peafed, he was quick and aCtive ; he was heavy and lleepy only when he had eaten to excefs. Another cafe, very fimilar to the above, was brought into view about the fame time at Liverpool that the firft was at Paris; and the lubjeCt of it was alfo a foldier in the French fervice. This cafe is recorded in the article Hunger, vol. ix. I hele are our modern inftances. A few' ancient ones, to which fome of our readers may perhaps not give full credit, are related under the word Gluttony, vol. viii. The writer of the article Medicine in the Ency. Brit, has obferved, that the pylorus being too large has l'ome- times caufed this difeafe. We need not remark on the abfurdity of this fuppofition ; becaufe every thing we know of thefe cafes evidently fhows that the digeftion of food is properly performed, a fad quite incompatible with She idea that the pylorus lets the food pafs too quickly. LOGY. In that cafe, indeed, the food would pafs almoft un¬ changed, and the ftools would of courfe be unnatural, and in large quantity; appearances actually the reverfe of thofe we have derailed. It is but juftice, however, to ftate, that in lientery, a difeafe in which much food is taken, this conformation has been difcovered. 7. L. exhauftorum, or voracity from exhauftion, as in the event of long abftinence, fevers, or exceftive dif- charge. This can only be coniidered as a natural phe¬ nomenon rendered more manifelt by its exciting caufes being longer or more intenfely applied. It affords us an opportunity of remarking on the danger of gratifying the appetite to its full extent after long abftinence, from whatever caufe it may.be produced. After long fading, indeed, fo many have been the fatal inftances that have occurred from a full meal, that it is now popularly known and guarded againft. After recovery from fevers and other exhaufting affeCtions, in which for a long pe¬ riod little or no fuftenance has been taken, the fame rule fhould in a minor degree be retained; but this regulation is not praCtifed even by our profeffional brethren, who are often found to prefcribe tonics and flimulants on the recovery of patients from febrile affections. The fame regard to quality is perhaps equally eftential; but, as the dietetic arrangements of convalefceuts, will be fully treated of, and as no very great errors are commonly committed on this bead, we ftiall pafs it over, leaving as a general direction, the precept of Horace — Nil nifi lene decet Vacuis committere venis. a. Limofis expers ; lofs or want of appetite, without any other apparent affeCtion of the ftomach. This is the ge¬ nus Anorexia of Sauvages, Linnaeus, Vogel, Sagar, and Cullen. Sauvages has thirteen 1'pecies, which would here rank as varieties, but which, as Cullen juftly ob- ferves, belong rather to the genus (in the prefent fyftem, fpecies) of dyfpepfy. The following have perhaps a fair claim to be noticed. a. L. defefforum; from too great fatigue, or the ex¬ pectation being w'orn out by delay. (3. L. pathematica ; from violent paflion or other ab- forption of the mind. This is chiefly produced by fevere grief, terror, ardent defire of obtaining an objeCt of pur- fuit, or religious enthufiafm. Of the firft we have an in- terefting cale by Dr. Eccles, in the Edinburgh Medical Effays for 1720, of a young lady about fixteen years of age, who, in confequence of the ludden death of an in¬ dulgent father, was thrown into a ftate of tetanus, or ri¬ gidity of all the mufcles of the body, and efpecially of thofe of deglutition, accompanied with a total lofs of defire for food, as well as incapacity of fwallowing it, for two long and diftinCl periods of time : in the firft in- ftance for thirty-four, and in the fecond, which occurred fliortly afterwards, for fifty-four, days ; “all which time (obferves the writer) of her firft and fecond fallings, (he declared (he had no fenfe of hunger or thirft ; and, when they were over, (lie had not loft much of her flelh.” Sau¬ vages alludes to a fimilar effeCt produced by religious ma¬ nia, and nymphomania. Nofol. ii. p. 805. 7. L. protraCla ; enabling the fyftem to fuftain almoft total abftinence for a long and indefinite time without faintnefs. As gluttony, or a defire to be perpetually eating, may be acquired by habit, fo may falling. The appetite of hunger feems, from various cafes, almoft as capable of being triumphed over as other appetites, and the body of being nourilhed by a very trifling quantity of food, and for many weeks, perhaps months, even by water alone. See Marcardier in Journal de Medecine, tom. xxxiii. Schenck, lib. iii. obf. 39. Waldfchmid, Diff. de his qui diu vivunt fine alimento. One of the beft-known and belt-marked examples in our own day, is that of Anne Moore of Tutbury. She was fufficiently afcertained to be a grofs impoftor, in pretending to be able to live without any food whatever : but 121 PATHOLOGY. but fhe feems, from long habit, to have loft all pleafura- ble defire for food, and to have been capable of fubfifting upon very fimple liquids alone. She was at firft induced to this habit by an extreme difficulty of deglution ; and ffie at length carried the habit fo far as, by deception, eafily to excite a general belief that flie never fwallowed any thing either liquid or folid. The intelligent committee, who fo laudably formed themfelves into a watch to deter¬ mine the ftate of the faCt, by a conftant attendance upon her perlon for a month, fufticiently proved that flie could notlive for ten days without fwallowing fome portion of liquid. In their report they tell us, that “ on the eighth day (he was exceedingly diftreffed,” her pulfe had in- creafed till it had amounted to 145 ilrokes in a minute ; and “ fo far was (lie reduced on the ninth day, that (lie became in danger of expiring;” while a few hours after¬ wards, when flie was compelled to confefs the iinpofture (lie had praCtifed, “ the pulfe at one wrift had entirely •ceafed, and the other feemed drawn to a thread.” Yet “ on the whole,” fay the committee, “ though this wo¬ man is a bafe impollor with refpeCt to her pretence of total abftinence from all food whatever, liquid or folid, yet fhe cun , perhaps, endure the privation of Jolidfood longer than any other perj'on. It is thought by thole bejl ac¬ quainted with her, that (lie exifted on a mere trifle, and that from hence came the temptation to fay that (he did r.ot take any thing. If, therefore, any of her friends could have conveyed a bottle of water to her, unfeen by the watch, and (he could have occafionally drunk of it, little doubt is entertained that flie would have gone through the month’s trial with credit. The daughter fays, that her mother’s principal food is tea ; and there is reafon to believe this to be true.” Full Expofure of Anne Moore, the pretended faffing woman of Tutbury. The cafe of Mary Thomas, a poor Welchwoman of Merionethffiire, refembles in fome points that of Anne Moore, but is (till more extraordinary, becaufe her mor¬ bid ftate was much feverer; and had been of longer dura¬ tion, comprehending the greater portion of a century. And it occurred about the fame time ; as Mr. James Ward, a royal academician, publiftied “ Some Account” of both thefe extraordinary women, “accompanied with Portraits and illuftrative Etchings,” (1813.) for he vi- fited them as an artift. From his narrative it appears, “that Mary Thomas has exifted between feventy and eighty years almoft without food ; and certainly, accor¬ ding to evidence that does not appear in any way objec¬ tionable, for ten whole years, without the lead particle of nutriment of any kind or form palling her lips, and without Ihowing any fenfibility or knowledge of external events; and has had, in that time, no excrementitious difcharges from the inteftines or urinary bladder. In 1812 this woman was Hill living ; and, from the extraor¬ dinary tenacity to life which fhe evidently poflefies, un¬ der circumftances that would have abridged the days of any other human creature, though now 80 years old, (he may, perhaps, long enough furvive to have her hiftory more explicitly detailed, and the faCls connected with her peculiar ftate decidedly unfolded.” This expectation was, however, defeated by the death of Mary Thomas during the year in which this account was written. On enquiring into the hiftory of this cafe, a fad has arifen of fome importance. Mr. Pennant, whofe reputa¬ tion for every thing excellent is ftill freih in our minds, faw Mary Thomas in the year 1770; and his relation agrees fo much with Mr. Ward’s, that they mutually fup- port each other, and give a degree of credibility to an otherwife incredible cafe. The great attention which was bellowed by the philo- fophica) world on the above cafes, together with the fpirit of inquiry which ftill exilts as to the poflibility of iu butting- without food, has induced us to make the fol¬ lowing extrads from a paper in the Harleian Mifcellany as being perhaps not without fome degree of intereft. The title of the paper is, “ A Difcourfe upon prodigious Abftinence; occafioned by the Twelvemonth’s Fading of Martha Taylor, the famed Derbylhire Damfel : proving that, without any Miracle, the Texture of Human Bo¬ dies may be fo altered, that Life may be long continued without the fupplies of Meat and Drink. By John Rey¬ nolds. Humbly offered to the Royal Society. London: Printed for Nevil Summons, at the fign of the Three Crowns, near Holbourn Conduit ; and for Dorman New¬ man, at the Surgeons Arms in Little Britain. 1669.” Quarto, containing 37 pages, befides the Title and Dedi¬ cation. Hurl. Mijcell. vol. iv. p. 43. The exordium, confining of a collection of fimilar in- ftances, bears ftrong teftimony of fuch occafiona! devia¬ tions from the courfe of nature; and we muft confefs, although at a lofs to account for it, we are by no means to difregard fuch a mafs of evidence, fince many other fads lefs palpable to the community at large, and much lefs fufceptible of proof, are believed, although equally inexplicable. Credulity and incredulity are alike the offspring of unreflecting habits. Too great a pliability on the one fide, and too much inflexibility on the other, are obftacles that will always interrupt the way to truth. That pen, however, as our author fays, “ certainly drops biafphemy, that dares to raze the facred records; and that uncharitablenefs which prefuines to write falfehood upon all human teftimonies : they that affent to nothing not confirmed by authority, are unfit to converfe in hu¬ man focieties ; for how can I expeCt that anybody fhould believe me, whillt I myfelf will believe nobody ? It is an. argument of an empty brain, to prefume to comprehend all things, and thereupon to rejeCt thofe things from ail exiftence in their world that have not their fcience in its intellectuals. “ Molt certain it is, that Mofes faded forty days and as many nights, whilft he abode in the burning mount ; Elijah went as long in the ftrength of a meal ; and no lefs was the fall of the holy Jelus. St. Auftin reports, that, in his time, one furvived forty days falling. The learned Fernelius faith, he faw a pregnant women that lived two months without meat or drink. Zacutus Lufl- tanus reports, that at Venice there lived a man that failed forty days ; another there forty-fix days ; and from Lon- gius and Fontius (two confiderable writers,) another full three years ; and that with juft ftature, good habit, free countenance, and youthful wit. The famous Sennertus is copious in fuch ltories : he relates from Sigifmundus and Citefius, a perfon he faith worthy of credit, that the people of Leucomoria, inhabiting fome mountains in Mufcovy, do every year die, in a fort, (or rather fleep or freeze,) like frogs or fwallows, on November 27, and fo continue in that rigid ftate ; the humour, diftilling from their noftrils, is prefently condenfed by the ambient cold, much like to icicles, by which thofe potent pores are pre¬ cluded, and the molt endangered brain fortified againft the fatal aflaults of brumal extremities. The fame Sen¬ nertus rehearfes a ftory of a virgin at Padua, from Vigun- tia, profeflbr there, who, anno 1598, was afflicted with a fever, then a tumor, then arthritic pains, and pains in the ventricle and whole abdomen; then with vomiting and naufeating of food, till at laft file could take no food for two months; then, after another fit of vomiting, purging, and bleeding, fhefafted eight months; and, after a little ufe of food, Ihe failed two months more. And, to be fhort, he (lories it of three perfons that failed each two years, one three years, another four, one feven, another fifteen, another eighteen, and one twenty ; yea, one twenty-nine, another thirty, another thirty- fix, and one forty years. Famous is the ftory, perhaps fiClion, being poetical, of Epimenides, (whole words St. Paul is thought to cite in his Epiflle to Titus,) whom fome report to have flept fe- venteen years, fome feventy-feven years, together. But enough of ftory : thofe that are defirous to read more, are referred to Marcellus Donat, lib. iv. de Med. Hift. Mi- rab. c. 12. Schenk, lib. iv. Obferv. Guaguinus, lib. iii. Hift. Franc. Petrarch, lib. iii. de Mirabel, c. 22. Portius de 322 PATHOLOGY. deHill. Puellse German. Ufpergenfis in Chron. Lentulus in Hill. Admir. Apol. Berius, lib. de Vini Nutritione. Bozius, lib. xi. c. 4.. de (ignis Eccl. Fulgorius, lib. i. c.6. Lepaeus, lib. ix. Hid. Scot. Fovorinus apud Gellium, lib. xvi. c. 3. and efpecially Licetus, who wrote a particu¬ lar tra£l to folve the phenomena of this prodigy. “ But, further to fatisty thefe incredulous perfons, it is affirmed that fome of thefe abftineuts have been watched By the mod wakeful eyes and jealous ears, to detedl their fraud, if guilty of any; as was that maid that refufed all food, except only water, for three years, by Bucoldianus, with whom (he abode for twelve days, at the command of Ferdinand the emperor; fo that Apollo.nia Schreje- rana was taken by the fenate of Bern, and put into the hofpitai of that town, and there watched till they were fatisfied of the truth of her total abllinence.” Mod of thefe cafes are certainly too unnatural to at¬ tempt to refute, however gravely they may have been af- ferted. Ufelefs, therefore, as the talk would be to dis¬ prove what nobody would believe, as well as to combat with arguments the exidence of what has been faid to be feen, believed, and fworn to, it would be equally unjud to doubt the authenticity of the whole. The cafe which the author himfelf has related, bears drong tedimony of the poffibility of the human body fubfiding under priva¬ tions of food for a number of days, if we do not give credit for the full time he has reprelented. This ab- ftinent, he fays, “is one Martha Taylor, a young damfel born of mean parentage, inhabiting not far from Bake- well in Derbylhire ; who, receiving a blow on the back from a miller, became a prifoner to her bed for feverai days; which being expired, (he obtained fome enlarge¬ ment for a time, but by increafing didempers was quickly remanded to her bed-prifon again ; where continuing fome time, (lie found, at lad, a defeat in her gula, and quickly after a dejeftion of appetite ; fo that, about the zzd of December, anno 1667, die began to abdain from all folid food, and fo hath continued, (except fomething fo fmall, at the feldom ebbings of her didemper, as is altogether inconfiderable,) till within a fortnight before the date hereof, which amounts to thirteen months and upwards ; as alfo from all other forts, both of meats and drinks, except now and then a few drops of the fyrup of dewed prunes, water, and fugar, or the juice of a roaded raifin, &c. but thefe repads are ufed fo feldom and in fuch very fmall quantities, as are prodigioufly infuf- hcient for fudenation : die evacuates nothing by urine or dool ; die fpits not, that I can hear of, but her lips are often dry, for which caufe (he takes water and fugar with a feather, or fome other liquids ; but the palms of her hands are often moid, her countenance frefh and lively, her voice clear and audible; in difcourfe die is free ; her belly dapped to her back-bone, fo that it may be felt through her intedines, whence a great cavity is ad¬ mitted from the cartilago enfiformis to the navel; and, though her upper parts be lefs emaciated, (though much too,) yet her lower parts are very languid, and unapt for motion, and the (kin thereof defiled with a dry pruriginous fcurf, for which, of late, they have wadied them with milk ; die deeps fo fparingly, that once die continued five W'eeks waking. Led lhe diould prove a cheat, (he hath been diligently watched by phyficians, furgeons, and other perfons, (for at lead a fortnight together,) by the appointment of the noble earl of Devonfhire, as is al- ' ready publidied by Mr. Robins, B. of D. that is, ballad maker of Derby; whofe ballad, they fay, doth much excel his book. Likewife feverai other perfons, at other times, have been pleafed to vyatch fortheirown fatisfaftion, who, detefting no fraud, have given the account above mentioned.” It was obferved by Dr. Henderfon, from Magn. Gabr. Block, that all examples of extraordinary fading have been confined to the female fex. This is another confirm¬ ation of the remark. Men, however, under circumdances ,of neceffity, have been enabled to endure fevere privations, even under confiderable bodily exertions. The crew ■of Bligh, and thehidory of many other navigators, give full tedimony of the powers that exid in mankind when their natural fupport has been materially reduced, and alfo totally taken away. The following particulars are col¬ lected from a note in Dr. Good’s Nofology, to which we have been already fo much indebted. Four men were preferved in a mine, from which, in eon- fequence of an accident, they were incapable of being ex¬ tricated for twenty-four days, without other food than water. Phil. Trunf. 1684. — A boy, fifteen years of age, faid to have lived three years without eating or drinking, with fever occafionally ; after this period he recovered tolerable health, excepting the ufe of one of his limbs, but even then took very little food. Id. 1720. by Patrick Blair. — A man, faid to have lived eighteen years on water, with occafionally a little clarified u'hey ; and locked up for twenty days in clofe confinement, with wateralone, to prove whether there were any impofition; meagre, and flip- pofed to have no evacuations; but in good health, and pur- fued hulbandry. Id. 1742. — A woman, from epileptic fits when a girl of fifteen, took to her bed, loll her appetite, and was attacked with lock-jaw, which, with a few (liort intervals, continued for four years : was on two or three occafions induced to take a little water, and her mouth was at times moillened with wetted linen through a cavity in her teeth, from two of them having been broken in an at¬ tempt to force the mouth open; but fwallowed nothing elfe. After this period, began gradually to recover front the tetanus, but had no defire for food ; and twelve years from the attack, when able to walk upright, took no more food than fufficie.nt for an infant of two years of age. Had no egefta, but when ingella, which were propor¬ tioned to each other, but fometimes a dewy foftnefs on her (kin. Dr. ^Mackenzie in Phil. TranJ'. vol. lxvii. 1777. This cafe is authenticated by numerous witnelfes of high refpeftability, and is entitled to peculiar attention. — Cafe of a woman, who loll all defire of taking food by a fall from her horfe into water during her firll menltrua- tion at the age of eighteen : for fifty years fcarcely ever took folids, her chief food being whey in the fummer, and milk, milk and water, or pure water, in the winter : had frequent retchings, which were cured by fmoaking to¬ bacco : for the fpace of fixteen years had only one (lool annually, in the month of March, refembling a globulet of (heep-dung: menfhuation never recurred, but occafional vomitings of blood. Edin. Med. EJf. vol. vi. 3. Limofis pica, appetite for improper and indigeftible fubltances. We have two varieties of this fpecies. a. L. infulfa, which arifes from want of talle or difcri- mination, as in infants and idiots. /3. L. perverfa. This arifes from corrupted fade or in¬ dulgence. It is often founded on the ablurd notion that eating chalk, acids, See. will produce a fair (kin. This variety anfwers to the malacia, fiaAaxia, of the Greek authors. When ariling from thefe caufes, chaftifement or advice can only be had recourfe to, and medical treat¬ ment is out of the queltion. It is to be doubted, how¬ ever, whether mere mental impreffion ever induces this complaint. It is more reafonable to fuppofe that the morbid (late of the (lomach is the caufe ; and, in fail, we fcarcely ever meet with a cafe of pica in which the galtric fecretion is not much altered. Looking to more remote caufes, uterine diforder appears often to influence the nervous fyftem in the firll inliance, and the (lomach fecon- darily. In the early ltages of pregnancy, and in chloro¬ tic lubjeits, the difeafe is moll generally found; and hence fome writers have fuppofed uterine irritation to be the foie caufe of pica. But this is certainly not the cafe j for we fometimes meet with the complaint in boys; and in the Well-India illands the negroes are often (ubjeft to it. It is rendered remarkable in the latter inltance by dirt being the (ubftance taken. It feems that regular ha¬ bits of diet have frequently cured the negroes of this dirt-eating, without the aid of medicine. (Sec Bryan 4 Edwards’s PATHOLOGY. Edwards’s Hiftory of the Weft India Iflands.) It has been fuppofed that the prevalence of an acid in the fto- iriach occaftoned the demand for earthy and abforbent fubftances in pica : but many of the fubftances, taken in different inftances, are not poffeffed of any antacid quali¬ ties. The diforder is very frequently beyond the power of medicine to relieve in a direct way. In the cafe of pregnancy, it commonly ceafes altogether about the fourth month, and has been relieved by blood-letting in ftrong and plethoric women : but in chlorotic girls it is only removed by the courfe of medicine which removes the morbid ftate of the habit in general, and reftores the na¬ tural difcharge where that was fufpended. In inftances where it attacks men, or women in whom the uterine functions are healthy, it ftiould be treated on the common principles of Dyfpepfia. It is aftoniftiing to note the various difgufting and in- digeftible articles fwallowed by the patients of this dif- eaie: chalk, allies, coals, foot, pitch, cinders, &c. have each been taken in fome cafes. But among the moft un¬ natural talles evinced under this affeCtion, though we do not agree with Dr. Good in calling it “ one of the moft common,” is that for fwallowing knives. In our own country it has occafionally occurred; (fee Knife- eater, vol. xi. p. 784.) but Plouquet, Init. Bibl. art. Pantophagus, has collected examples from almoft all the different ftates of Germany and the neighbouring prin¬ cipalities, Balle, Pruftia, Prague, and different parts of Ruffia. Another curious propeniity is that of fwallow¬ ing glafs, of which alfo the inftances are numerous. But thefe, as well as eating hair (Brefl. Sammlung, 1719.) and ordure (Borell. Obf. cent, iv.) mu-ft rather be confi- dered as inftances of folly and bravado, than of tafte. Not fo, however, the y. L. pica nali, a name given by Cohaufen to the im¬ moderate and habitual taking of fnuff, a filthy depravity common to both fexes ; and which, after being confined for fifty years, in this country, to the old women of the old French fchool, has been revived by the dandies of the prefent day. It has not yet reached the ladies; and fo we hope it may end where it has begun, with the moft contemptible part of the creation. Pica nafi feems a whimfical term; but Cohaufen has chofen to treat this habit as adifeafe, and has written an exprefs treatife con¬ cerning it. The word pica, in general, denotes an abfurd and unnatural appetite; and the define of taking the powder of tobacco in this manner is called a diftempered appetite of the part into which it is taken, that is, the nofe. The confequences of the taking fnuff immode¬ rately, are, that the fenfe of fmelling is either entirely deftroyed, or at lead greatly impaired : for the nervous tubercles of the noftrils, being continually' vellicated by this powder, are by degrees clogged up, or wholly defi- troyed ; and the fenfible membrane, which lines the nof- trils, is rendered callous, and wholly unfit for the dif¬ charge of its office in fmelling. The voice is next af- f'eCted by this powder; for it caufes a fort of aftriCiion at the bottom of the nofe, which affeCts the palate, and confequently the fpeech; this gives the perfon who takes it a continual defire of taking more and more, to rid him- felf of that ftoppage. As we are treating of morbid longing, it may not be improper to mention, that many perlons recovering from febrile affeCtions experience a particular defire for articles of food which we ftiould, a priori, be inclined to think highly prejudicial, and confequently to deny them the enjoyment of. But experience has fliovvn, that in this cafe the inftinCt may be often fafely indulged : a rule to be admitted, however, with much caution and reftriOion. 4. Limofis cardialgia. This and the two following fpecies we find it impoffible to confider in any other light than as fymptoms of indigeftion. We (hall therefore give but a brief account of them. Cardialgia has three varieties : a, mordens ; £, fyncopalis ; y, fputatoria. a. L. mordens is that painful fenfation of heat and Vol. XIX. No. ii9a. 123 acrimony about the fuperior orifice of the ftomach, which, from the vicinity of its feat to the heart, is popu¬ larly called heart-burn. It is produced by the irritation of acid matter in the ftomach, which rifes to the upper orifice, fometimes by eruCtation into the cefophagus and throat, and is fometimes completely ejected by vomiting. That this irritating matter is of an acid nature, is evinced by the tafte ; and it has even been feen to produce an effervefcence on falling on a marble hearth, according to Dr. Darwin. When vomited, or raifed by eruCtation, it is fometimes fo intenfely four as to abrade the mouth and throat; and, in general, it produces a fenfation in thefe parts fimilar to that which exifts in the ftomach. The production of this acid may arife from two fources. If the gaftric powers are fo deficient that they cannot within a certain time digeft the food, and propel it from the ftomach, fermentation will take place, and acid will be generated. Abetter explanation feems to be, that the acid is lecreted, that it is gaftric juice changed from its natural ftate. That this is the cafe feems probable, be- caufe acid eruCtation is often felt fo foon after a meal, that it is impoffible acid could be generated by fermenta¬ tion ; and moreover we have known eruCtations poffeffing the higheft degrees of acidity to pafs from a patient whom we had confined for many cfays to an animal diet. The palliative remedies are alkalies. Dr. Darwin remarks, that, as the faliva fwallowed along with our food prevents its fermentation, according to the experiments of Pringle and Macbride, confiderable relief is fometimes found by chewing parched wheat or rnaftic, or a lock of wool, fre¬ quently in a day, when the pain occurs, and by fwallow¬ ing the faliva thuseffufed. £. L. fyncopalis. This appears to differ from the laft only in this, that the production of the acid is attended with fo peculiar an effeCl on the nerves of the ftomach, that feelings of extreme weaknefs and fyncope are expe¬ rienced. The pain, too, which in the firft variety is felt in the upper extremity of the ftomach chiefly, is extended in this to the lower part of the fame organ. 7. L. fputatoria, or water-brafh ; the pyrofis of Cul¬ len. It is a burning pain extending over the epigaftrium, with an eruCtation of watery fluid, ufually infipid, fome¬ times acid. This difeafe comes on in paroxyfms, which ufually happen in the morning and forenoon when the ftomach is empty. The firft fymptom is a pain at the pit of the ftomach, with a fenfe of conftriCtion, as if the ftomach were drawn towards the back: the pain is increafed by railing the body into an ereCt pofture, and therefore the patient bends himfelf forward. This pain is often extremely fevere, with a fenfe of burning ; and, the fluid continues to be brought up for fome time, and does not immediately give relief to the pain which pre¬ ceded it ; but at length it terminates the pain, and the fit ceafes. Thefe paroxyfms come on without any evident caufe, nor is the origin of the difeafe always to be im¬ puted to any particular fort of diet. It feldom, if ever, attacks thofe people who ufe frefti animal food daily ; but appears to be moft common among thofe who live almoft entirely upon tea, milk, potatoes, and farinaceous fub¬ ftances. It is much more common in women than in men; fometimes it attacks pregnant women, and often thofe who labour under leucorrhcea. It feldom occurs in any one before the age of puberty, or in thofe who are confiderably advanced in life : when it has once taken place, it is very prone to recur occafionally for a long time afterwards. It is more common in Scotland than in this country, and chiefly affects the lower claffes of the people. The paroxyfm is moft effectually relieved by anodynes, efpecially opium, hyofeiamus, and coniurn ; and with lefs certainty by other ftimulants and antifpaf- modics, as fulphuric ether, ammonia, and the tinCture of guaiacum, Thefe remedies, however, do not materially contribute to prevent the recurrence of the difeafe. 5. Limofis flatus, or flatulence, is the generation of air in the inteftinal canal, which, like the production of K k acid, PATHOLOGY. 124 acid, C3n have only two fources ; viz. either from the chemical changes which the food undergoes in confe- quence of deficient fecretion, or from the altered ftate of the fecretions themfelves ; for there is little doubt that air may be fecreted, as Mr. Hunter firft fuggefted. There are three varieties of this complaint : a, borborygmus; (2, eruftatio ; y, crepitus. a. The firft Variety of flatus is indicated by a fenfe of uneafinefs, with a rumbling or gurgling noife in the belly. It isfometimes very diftrefling, fince it draws the at¬ tention of by-ftanders; and is not uncommon in young women, about the age of puberty. “ I attended a young lady about fixteen,” fays Dr. Darwin, “ who was in other refpefts feeble, whofe bowels almoft incefiantly made a gurgling noife fo loud as to be heard at a conliderable dif- tance, and to at t raft the notice of all who were near her. As this noife never ceafed a minute together for many hours in a day, it could not be produced by the uniform defcent of water, and afcent of air through it ; but there muft have been alternately a retrograde movement of a part of the bowel, which muft again have puthed up the water above the air ; or which might raife a part of the bowel, in which the fluid was lodged, alternately above and below another portion of it, as might happen in fome of the curvatures of the fmaller inteftines, the air in which might be moved backward and forward like the air-bubble in a glafs level.” Dr. Darwin recommends “ ten corns of black pepper fwallowed whole after dinner, that its effefts may be flower and more permanent,” in the borborygmi of young women. We have feen them fuf- pended by any fubftance, taken into the ftomach, as a piece of dry bifcuit, which, by the way, the late Dr. Buchan confidered “as one of the beft carminative medicines,” and recommends it in all complaints of the ftomach, ari- fing from flatulence and indigeftion. Thefe diforders are often particularly troublefome when the ftomach is nearly empty ; and perhaps the operation of a bifcuit taken at fuch times is merely that of relieving this tem¬ porary vacuity, which any other light aliment would equally efteft. 0. The fecond variety, eruftatio, is of courfe pro¬ duced by the aftion of the mufcular fibres of the ftomach on thecontained food. When this fymptom does not take place, and wind is pent up in the ftomach, it produces all the diftrefling confequences which are attendant on great diftention of that organ. In fome inftances great pain of the ftomach is excited, either by the Ample extenfion of the fibres, or by partial fpafmodic contraftions ; great anxiety and oppreflion are felt in the cheft; the refpiration becomes laborious and difficult, with a fenfe of fuffocation ; and the heart intermits in its aftion, giving rife to intermiflion of the pulfe, or is excited to violent palpitations. Thefe fymptoms are generally alleviated by the difcharge of wind by eruftation : this alleviation, however, is only temporary; for the flatus again accumu¬ lates, and re-produces the fame effefts. The generation of air in the ftomach, in lefs degrees, is an ordinary con¬ comitant of indigeftion ; but it generally pafles off readily. Some people, indeed, acquire a habit of voluntary eruftation, which, Dr. Darwin fays, augments the malady. He obferves,“ that, when people voluntarily ejeft the fixed air from their ftomachs, the fermentation of the aliment goes on the fafter; for flopping the veflels which contain new wines retards their fermentation, and opening them again accelerates it ; hence, where the digeftion is impaired, and the ftomach fomewhat diftended with air, it is better to reftrain than to encourage eruftations, except the quantity makes it neceflary.” (Zoonomia, Clafs i. 3. 1.) It has been fuggefted, but, we think, incorreftly, that, in the repeated voluntary attempts to difpel wind from the ftomach, which are often continued for fome length of time, the atmofpheric air is often aftually fwalloued, and the difagreeable fenfation of diftention thus augmented. For the relief of flatulence, (the radical cure, as we have already obferved, can only be effefted by curing the dyfpepfia,) a number of medicines have been devifed, from a very early period of time, efpecially fuch as are comprehended under the appellation of carminatives. Thefe are generally fubftances pofl'efling ftrong fenfible qualities, which render them inftantaneoufly ftimulant to the nervous fyftem ; and, by fuddenly exciting the muf¬ cular coat of the ftomach to aftion, enable it to overcome the diftenfion, and difpel the diftending gas. The aro¬ matic vegetables, containing much eflential oil, fuch as juniper-berries, the feeds of anife, carraway, and cori¬ ander, fhe roots of ginger and zedoary, and the waters diftilled from thefe, are among the mod efteemed car¬ minatives. To thefe may be added other ftimulant and antifpafmodic medicines; fuch as aflafcetida, and other ftrong-fmelling gums ; volatile alkali ; opium, ether, &c. Warm fomentation externally to the region of the ftomach has been recommended by Dr. Darwin, and other ex¬ ternal remedies were employed by Dr. Whytt; efpecially friftions on the region of the ftomach, with liniments compofed of the warm oils ; fuch as the exprefled oil of mace, oil of mint, See. and alfo the application of large plafters to the belly, made with the ftimulating gums and gum-refins. y. L. crepitus, is a term ufed to exprefs the expulfion of wund ab ano. We confefs ourfelves totally at a lofs to con¬ ceive why this expreffion was introduced into a fyftem of nofology. 6. Limofis emefis, rejection of the contents of the ftomach, or tendency to rejeft. This afteftion feems the fimpleft form of gaftric difturbance. It is generally the immediate confequence of diminilhed nervous influence. Thus, blows on the head, injury of the nerves, or fym- pathy with difenfed vifeera, readily excite it. It has three varieties, which are only different degrees of the fame aftion ; and that aftion is, as we have faid before, only a fymptom of other difeafes. The firft variety, a. L. nauftea, or loathing, is the mere fenfation of ficknefs without vomiting. The caufes of naufea are numerous. We (hall mention the moft frequent one, viz. dilordered digeftion, under that head. The brain is feldom materially aftefted by any feriotis irritation or derangement, without deranging the ftomach by fympathy : thus, ficknefs at the ftomach is a common fymptom of every degree of local injury of the head, in which preflure or concuflion of the brain is occafioned; it accompanies inflammation of the brain and its mem¬ branes, the preflure of water in the ventricles, or ofother morbid effufion or growth within the cranium ; as well as the oppofite ftate or inanition of the veflels of the brain, as in fyncope, or after great Ioffes of blood. The other or¬ gans, with which the ftomach is often fympathetically de¬ ranged, and fickened, are chiefly the kidneys and the uterus. Thus naufea is a common concomitant of inflammation in the kidneys, or of the irritation of gravel or of a ftone lodged in thefe organs, and becomes one of the diagnoftic marks by which difeafe in the kidneys is diftinguifhed from other painful affeftions of the loins. Sympathetic naufea is alfo a frequent concomitant of uterine irritation or diforder ; thus it is one of the moft frequent fymptoms of the beginning diftention of the uterus in pregnancy, and accompanies inflammation and other painful con¬ ditions of that organ. The influence of the mind alone is likewife capable of exciting naufea, and even its ul¬ timate degree, vomiting. The fight, or even the de- feription or imagination, of loathfome and offenfive objefts and aftions, will produce this effeft on the ftomach of many individuals of refined habits, or who are unac- cuftomed to fuch objefts. It is not eafy to account for that variety of ficknefs, which is produced by certain kinds of motion of the body, fuch as fwinging, whirling, and the undulating motion of a fhip at fea. It feems, however, to be referrible prin¬ cipally to the fympatlietic connexion between the ftomach and brain ; i. e. to the vertigo ordizzinefs produced in the latter, through the medium of the organs of vifion, by thefe 4. unufuai PATHOLOGY. unufual motions. Sicknefs and vertigo are mutually pro- duftiveof each other, like fomeotheraffeftions of the head and ftomach. When the ftomach is rendered Tick by wine or naufeous drugs, a giddinefs is perceived, even with clofed eyes, and vice verfti. Dr. Darwin mentions a ftriking fait illuftrative of the effeft of this dizzinefs, produced through the organs of light, in bringing on and preventing fea- ficknefs. “ In an open boat palling from Leith to King- horn in Scotland, a fudden change of wind fliook the undiftended fail, and ftopt our boat ; from this unufual movement the pafl'engers all vomited except myfelf. I obferved, that the undulation of thelhip, and the inftabi- lity of all vifible objects, inclined me firongly to be fick ; and this continued or increafed when I clofed my eyes, but, as often as I bent my attention with energy on the management and mechanifm of the ropes and fails, the licknefs ceafed; and recurred again as often as I relaxed this attention.” (Zoonomia, feft. xx.) Similar naufea, though lefs in degree, is commonly an attendant on the vertigo produced by looking from a high tower, or at¬ tempting to crofs a narrow path, unfupported, over a deep chafm. As this is fo evidently a mere fymptom of difeafe, the treatment of it embraces a large field of difcufiion, vary¬ ing according to its aetiology. As a palliative, effervef- cing draughts, or, when acid only is prefent, alkalies are ferviceable. It is to be obferved, that the prafticeof refort- ing to emetics on all occafions of naufea, is injudicious ; and probably aggravates the evil tenfold, by augmenting the irritability and feeblenefs of the ftomach, and thus laying the foundation for permanent imbecility in that important organ. £. L. vomituria, retching, or an ineffeftual effort to vomit. In this fymptom the patient, by a voluntary aft, endeavours to rejeft the load which opprefles him ; but, the fympathetic aftion between the ftomach and the invo¬ luntary mufcles concerned in this aft not being fufficiently in force, its performance is reftrained. y. Vomitus, vomiting, or rejeftion from the ftomach. The aft of vomiting is produced by the fame caufes as naufea, though they exift in greater degree. The fame palliatives are in ufe. Among other affeftions analogous to this, muft be no¬ ticed rumination. Itis known to bea natural and voluntary aft in animals which have a plurality of ftomachs, as the ox, fheep, deer, goat, and camel ; (fee vol. xiv. p. 236.) but unnatural and very rare in the human fubjeft. Yet it is by no means a difeafe, but rather a peculiar con- ftitution of the cefophagus ; and thofe who have this faculty “ have declared,” fays Blumenbach, “ that they had a real enjoyment in it; and that with them, as with the clafs pecora, it was a voluntary aft.” In exhibiting the hiftory of our knowledge upon this fubjeft, it is a matter of difficulty to determine whether it was known to the ancients, and, if known, in what light they viewed the affeftion ; for it is evident, that we cannot, with juftice, call it a difeafe, feeing that its pof- felfors do not confider it fuch, from its being, on the con¬ trary, rather attended with confiderable enjoyment. If we confider the habits and boundlefs luxury of the civilized among the ancients, the manner in which the ftomach was unloaded of a previous meal, in order to re-enter upon a fecond gratification of the palate, among the Grecian and Roman gourmands, in their refpeftive eras of luxury, it may be eafily inferred that fuch an affeftion as that we are now employed to defcribe, would have been confidered a moil delightful fource of animal grati¬ fication ; and^certainly would not have been the lefs indulged, nor would the enjoyment have been diminifhed, had a fimilar opinion been entertained by their phyficians as was propagated by honeft Fabricius ab Aquapendente, that the pofleflor was endowed with a double ftomach, and that the other beftial concomitants might, in procefs of time, be expefted, either in themfeves or their more beftial defcendants. 12-5 Galen, who had ample opportunities of obfervation among the many inftances of indigertion he muft have met with in the luxurious court of the Antonines, does not give the hiftory of a fingle cafe ; and, amid the various ftomach-aches and affeftions of Marcus Aurelius, which, it would appear, both puzzled the brain and excited the anx¬ iety of this prince of phyficians, fo as to make him afraid that a glafs of fpiced wine might be too hazardous a re¬ medy for the good emperor, the faculty of regurgitating his meals for a fecond maftication, appears not to have en¬ tered into the number. Fabricius ab Aquapendente furnilhes two of the earlieft inftances of human rumination. The firft is of a noble¬ man, in whom it generally took place an hour after his meals; which, whether folid or fluid, were always returned, in order to undergo a fecond maftication. Fabricius thought it proper to mention that the father of this indi¬ vidual had a horn growing from his forehead ; and, with great good faith, adds, “ ex quo forte datur nobis intel- ligi, parentis femen aliquam habuiffe cum cornugeris ani- malibus, neque mirum fuifle genitutn filium fimile, quid a parente contraxiffe :” that, although the fon did not inhe¬ rit his father’s horns, yet he poflefled the accompanying faculty of rumination. The fecond inftance with which Fabricius has fa¬ voured us, was in a monk, who, although poflefled of a moft ravenous appetite, died of marafmus. This monk was poflefled of ft ill higher beftial attributes ; for Fabricius defcribes him as having his forehead loaded with two horns; and Johannes Burgovverrus, who vifited this monk in the company of Joh. Prevotiusand Thos. Minadous, wrote a DiflTertation on this interefting individual, and afforded Fabricius with the particulars which are inferted in hi.s works. Burgower alfo adds, that the brother of this monk was alfo adorned with two budding horns, “ Duorum cornum veftigia geftafle,” as a Jlriking feature of family-likenefs ; or, as this author will have it, “ Quod enim fratris erat, id monacho ruminanti fimul gratis im- petiunt.” But this illuftrious individual did not rumi¬ nate, unhappily for the argument of Thos. Bartholinus, who, from thele two individual inftances, haftens to the conclufion, (in his TreatiJ'e ds Unicornu, cap. 2.) from the obvious analogy of the cornugera pecudes, that all hu¬ man ruminants are poflefled of horns; and alfo avers, that a double ftomach will always be found on diffeftion. Sennertus furniihes another hiftory of a man of forty , who poflefled this faculty from a child. He finds no difficulty in accounting for its occurrence, when he learnt that, when a child, this individual had loft his mo¬ therland had been fed during his non-age with the milk warm from the cow. He accordingly foberly concludes, that he fucked it in with his nurfe’s milk ! Philip Salnuith furnifhes us with another inftance of human rumination. It always took place in this indivi¬ dual about a quarter of an hour after having left table. He always ate ravenoufly, and fwallowed his food almoft without any previous maftication. John Faber Lynceus (in Expofitione Hiftor. Nardi An- thonii Recchi, p. 630.) gives an inftance of moft obftinate rumination in a highly-rel'pefta'ole German, who, even when feated over his cups with his friends, was always obliged to retire about half an hour after the meal into a remote corner of the apartment, and then ruminate the ingefta, undifturbedly and as quickly as poffible; which having done, he enjoyed uninterruptedly the fociety of his friends. Having been afked how he became obliged to indulge this propenfity, he anfwered that from a boy he had been fubjeft to acid eruftations ; that, after having reached his thirtieth year, he found it impof- fible to refill admitting into his mouth the food that conftantly regurgitated from his ftomach. And, being farther interrogated whether the fecond maftication of his food could polfibly afford him any gratification, “ Indeed,” he replied, “ it is fweeter than honey, and accompanied by a more delightful relilh.” This PATHOLOGY. 126 This affeftion might be faid to be in the family of this lioneft German; for he was blefl'ed with two grown fons : the older, of twenty-four years, alfo poffefled this delightful faculty, but had it more under control than the father, as he could prevent it altogether when in company. The younger could not. G. H. Velchius adduces another example, in an inhabi¬ tant of London ; who, in the fortieth year of his age, and of found health, always returned his food, in order to undergo a (lower and more deliberate maftication. Rumination moftly took place in this individual from an hour to two hours after a meal ; but even at the remoter period it ftill preferved a pleafant tafte, and was without any degree of acidity. In an inftance adduced by Daniel Ludovicus (in the Ephemerides Nat. Cur. anno ix. and x.) that occurred in a young woman, this aft was not performed with the ufual pleafure, and the returned food pofleifed a more difa- greeable tafte than that which accompanies the more perfeft cafes of this affeftion. Bitters and ftomachic pur¬ gatives did not prevent its occurrence, which however was not always regular in its appearance ; and, although carthartics and emetics prevented it for a (hort period, it foon returned. John Conrad Pyer (Merycologia, cap. vi. ) mentions a cafe in a fatuitous young man ; alfo its occurrence in a ruftic in Swifferland ; and in a woman in the neighbour¬ ing town. He fagely endeavours to prove, from the cir- cumltance of thofe individuals being rullics and cowherds, that the frequent fight of the ruminating procefs had imprefied their brains with a fimilar propenfity, which, although imperceptible in its progrels, had neverthelefs ripened into maturity. Slare (in an early volume of the Phil. Tranf.) mentions the cafe of a Briftol man, who appears to have pofleifed this faculty in its perfeftion. This individual not only ruminated the folid ingefta, but alfo fluids, as milk and foups. There was, however, one imperfeftion con- nefted with this cafe, as it relates to the (late of this man’s Itomach during his meals ; that the viftuais feemed fcarcely to defcend into tiie Itomach, but to lie in the low'er part of the throat. However, the portion of the meals firft taken was firlt ruminated. In a cafe related in the 286th Number of the Journal general de Medicine by Mr. Tarbes, as quoted by the Editor of the London Medical and Phylical Journal, the prominent phenomena were nearly the fame 3s the one juft related. Rumination was firft manifefted by the patient after his recovery from confluent fmall-pox, in the fixth year of his age ; and it was conllantly performed after every meal, until the period of its total ceflation. About half an hour after having eaten, he fuffered a flight uneafinefs in the epigaftric region ; this fenfation was followed by the tranfmiffion of a ball of food from the ftomach to the mouth. The aliments thus brought up had neither a difagreeable odour nor an acid tafte, and did not appear to have undergone any alteration in the ftomach. The patient chewed them with as much plea¬ fure as he did on firft taking them. After this portion was again fwallowed, another mafs, which did not appear to have been mingled with that chewed the fecond time, was brought into the mouth ; and fo, in fucceflion, all the food he had taken at his laft meal was returned. On fit¬ ting down to eat his food, the patient, inftead of mafti- cating well what he took, only divided it in a very im- perfeft manner, as might be feen by the fpecimens re¬ turned into the mouth during rumination. If he, by chance, happened to (leep foon after a meal, he, after about two hours, awoke to vomit up all the food which had not been ruminated. He went on in this way until the time of his marriage, when his rumination ceafed, almoft fuddenly. It was leflened on the day enfuing from it, and was entirely difcontinued at the end of eight days. A great thirft, which he had fuffered whilft he ru- /ninated, difappeared at the fame time. He fuffered no inconveniences in confequence of the change ; and, during the fix years which have fince elapfed, he has become more robuft and healthy than before. Dr. Copeland has related a curious cafe of this kind in the London Med. and Phyf. Journal, No. 267, for May laft (1821.) The fubjeft of it was a gentleman in the meridian of his age, of a ftrong but fpare habit, and of the fanguineo-melancholic temperament. Owing to caufes to which he was fubjefted through the very early period of life, he had been obliged to take his meals in a very hafty manner. The very few minutes allowed to his ordinary meals led to a hafty and imperfeft maftication of the food ; and, although his time was at his own dif- pofal as he reached manhood, ftill the habit had been re¬ tained through the reft of the already pafled portion of his life. The greater part of its early period was fpent in an aftive, varied, and pleafant, employment, generally in the open air, and in the vicinity of the fea; and this alter¬ nation of aftive exercife, in fo healthy a fituation, pre¬ ferved the due equilibrium of the organic aftions ; the former neutralizing the effefts produced upon the digef- tive funftions by the co-operation of an hafty and imper¬ feft maftication of the ingefta, and by fedulous ftudy. So long as this diverfified mode of living was enjoyed, the regular operation of the digeftive tube was conti¬ nued, and no fymptoms of dyfpcpfia appeared, until he took up his conftant refidence in the metropolis. For a confiderable time, the chief and almoft only complaint was fputatoria, or water-qualm : for two or three hours after every confiderable meal, part of the more liquid contents was ejefted from the ftomach, in large mouth¬ fuls, at intervals of from two to five or ten minutes, at¬ tended with a flight acidity ; fometimes with a flight fla¬ tulence and fenfe of fullnefs at the ftomach, but never with any cardialgia, nor with the flighted fenfation of naufea. This affeftion was generally augmented by any of the ufual articles of defert, or by port- wine ; while it was relieved, or entirely prevented, by a moderate quan¬ tity of white wine, and by avoiding every fpecies of ex¬ ertion that could tend to difturb the funftion of digef- tion. This affeftion, after continuing feveral years, with occafional interruptions, according to the care and means taken to prevent it, pafled at laft into complete rumination, which has been prefent after every confide¬ rable meal for fome time. But, as it was attended with lefs inconvenience than the preceding fputatoria, and being unaccompanied with any difagreeable fenfation, no great importance was attached to it, until it became complicated with a cutaneous eruption. For that I was confulted; and, upon making inquiry into the ftate of the digeftive organs, was readily informed of the rumi¬ nating affeftion. The profefiional intercourfe that now took place furniflied me with the particulars already re¬ lated, which may ferve as an introduftion to a know¬ ledge of the nature of this difeafe. The following is a ftatement of the particulars of this cafe, when fubmitted to my care. The ruminating af¬ feftion was at that time generally prefent after all his meals, and conftantly after breakfaft and dinner. The appetite was always good, and the food, conftantly taken in large mouthfuls, was mafticated haftily and imperfeftly, and fwallowed eagerly. There was no thirft ; the bowels were habitually coftive. Sleep was found. His meals were taken more with a defire to fatisfy an unpleafant fenfation or a requifite defire, than to indulge the plea- fures of the palate, and was performed haftily, in order that the ftudies and purfuits, to which he confidered eating an interruption, might be immediately refumed. Under the ufual circumftances, rumination commenced from a quarter of an hour to an hour and a half after a meal. Immediately upon the commencement of this aft, a flight fenfation of fullnefs might be felt at the cardia, when the attention was particularly direfted to it, that led to a deeper infpiration than ulual. So foon as the 127 P A T H O n£t of infpiration was completed, and while the mufcles of the glottis remained fixed, a bolus of the unchanged aliment rofe rapidly from the ftomach, with the firft effort at refpiration, at the moment when the diaphragm had juft relaxed, and the re-aCtion of the abdominal mufcles commenced. But expiration did not take place until the alimentary ball had pafled completely into the mouth, as the glottis remained clofed until then : upon this having taken place, expiration was immediately effected ; and fo rapidly did expiration fucceed to the regurgitation of the alimentary bolus, that the latter (unlefs when the attention was clofely applied to the fubjeCt) appeared as part of the expiratory aCt. The ruminating procefs was never accompanied, at any time, with the fmalleft degree of naufea, nor any pain or difagreeable fenfation. The returned alimentary bolus was attended with no unpleafant flavour, was in no degree acidulous, and was equally agreeable, and was mafticated with additional pleafure, and with much greater deliberation than when firft taken. The whole of the aliments received at any one meal was not re¬ turned in order to undergo this procefs, only the part that had undergone an infufticient maftication ; but which indeed conftituted the greater portion of folid aliment. That taken at the commencement of a meal was the firft difgorged ; this was afcertained by eating from a variety of lolid difhes, or from partaking of different portions of the fame. The more fluid portions were not always re¬ turned, unlefs along with the more folid or imperfectly mafticated parts. When, however, the ft’omach was diftended by a large meal, the fluid contents were fre¬ quently returned, and fubjeCted to this procefs. This affeCtion may be confidered as having been paflive- ly under the control of the will j and, although it fome- times took place when nearly unconfcious of the pro¬ cefs, yet it never occurred when the mind was incapable of being aCted on by external impreflions received by the fenfes. Thus, if at any time, from previous fatigue, and the concentration of the organic nervous energy towards the digeftive organs, fleep was induced immediately after a full meal, this affeCtion did not take place; but flatu¬ lence, acrid eruftations, &c. afterwards fupervened, and continued for fome time, in confequence of the gaftric j uices being inefficient to the production of the requifite changes on the ingefta retained in a ftate of imperfeCt divifion. Very frequently, when the ruminating procefs was thus prevented, or voluntarily fuppreffed when cir- cumftances required it, the ingefta, both fluid and folid, were returned at the end of feveral hours ; but w:ere then generally acid, frequently acrid and bitter, and fometimes in fo large a quantity as to fill the mouth beyond its ca¬ pacity of retention. But even then no cardialgia nor gaftrodynia was experienced, nor the fmalleft degree of naufea ; and even thefe difgorged matters were attempted to be mafticated, although generally thrown out on ac¬ count of the difagreeable tafte. “ In fpeculating upon the nature of this cafe,” fays Dr. C. “ it appears evident that the energy of the digeftive and affimilating organs was greatly diminifhed: confe- quently the ftomach, deriving its influence, whether that prefiding over the mufcular aCtion or vafcular fecretion, from the fame fource, namely, the organic fyftem of nerves, experienced a proportionate diminution in its fe- creted juices. This was rendered apparent by the changes which took place in the aliments, when taken even in very moderate quantity, and when retained without being fubmitted to re-maftication. Connected with de¬ bility of this organ, an increafe of its animal fenfibility, which it derives from the diftribution of the eighth pair of nerves, appears to have been prefent. Under thefe circumftances, the gaftric juices (being, as inferred, in dim in idled quantity) could be fufficient only for a fmall portion of aliment, which neverthelefs had been taken in an abundant quantity; and, having combined with that part whofe ftate is moft favourable to fuch an ad- VOL.XIX. No. 1292. LOGY. mixture, and being, by the ufual aCtion of this organ, conveyed to the pylorus, the imperfeClly-mafticated portions, and that part which remains impenetrated by the gaftric juices, tnuft either continue at the cardiac ex¬ tremity, or be propelled there by the aClion of the fto¬ mach. That the undigefted portions of the food do not only remain in that fituation, but may, by a peculiar and complicated aCtion of this organ, be conveyed there, may be proved not only by reafoning upon the nature of its organic aClion, but has even been demonftrated by large fiftulae of this organ, fituated at its anterior con¬ vexity, and opening externally at the epigaftric region. In a cafe in the Hopital de la Charite, under the care of Corvilart, the complicated aClion of this organ was wit- nefled, conveying the digefted portions of the ingefta towards the pylorus, which pafled only in very fmall quantity, while the bulk of the unchanged aliment was propelled, by a contrary aCtion, to the oppofite extremity of the organ. It cannot be fuppofed improbable that the irritation produced in this part of the ftomach by the un¬ changed aliments in ruminating individuals, fliould ex¬ cite the animal fenfibility of this organ ; and, if the hrain be in a ftate capable of receiving the fenfation, it is pro¬ pagated to the organs of refpiration, and their aCtion induced through the medium of the fame let of nerves, namely, the par vagum, that forms not only the refpira- tory clafs, but alfo the connecting chain between the or¬ ganic and animal orders of the grand nervous fyftem ; and, while it bellows an exquifite fenfibility on the pul¬ monary fyftem, it likewife gives a requifite, but fparing, (hare of its influence to this important organ. “In effecting the procefs of rumination, the organic contractility of the ftomach can do no more than, by an elective procefs (foon to be explained) , place the aliments about to be returned in a fituation, in refpeCt to thecar- dia, favourable to the excitation of the animal fenfibility of this organ, and to its ready regurgitation and propul- fion along the cefophagus. So loon as the demand is made upon the fenfibility by the fituation of the alimen¬ tary bolus, the par vagal clafs of nerves is excited to aCtion, and a full infpiration is effected, as has been de- fcribed. The introduction of the bolus into the cardiac extremity of the cefophagus, may be confidered as ef¬ fected by the ordinary contractility of the ftomach ; per¬ haps fympathetically heightened at the moment by the re-aCtion of the abdominal mufcles ; while, at the fame time, the diaphragm has juft undergone relaxation, in which the cardia may, from intimate nervous commu¬ nication, fuffer a fimilar participation, and thus give fa¬ cility to the afcent of the alimentary ball in the cefopha¬ gus, which immediately contracts behind it from the ir¬ ritation produced by its pafl'age, and the bolus is thus conveyed to the mouth. “The influence of the will appears to be requifite, fince the procefs is interrupted during fleep. But this influence is only puffively engaged in the production of the ruminating aCt, by bringing about the co-operation of the refpiratory organs. The elective procefs exer- cifed by the ftomach in this affeCtion, is fimilar to that which it employs in periods of health, and may be con¬ fidered as relative to the degree of digeftive energy, and to the comparative dates in which the various ingefta may enter the ftomach. “In the debilitated ftate of the ftomach, and confequent deficiency of the fecretions, digeftion can be perfectly performed only when the aliments are prefented in fmall quantity, and in a favourable ftate, from complete com¬ minution and from intermixture with the falivary juices. If, however, in this ftate of the organ, the food is con¬ veyed rapidly into it, poflefled of neither of thefe requi- fites, fo as to produce fudden diftention, a re-aCtion of this vifcUs upon its contents takes place; and, as the im- perfeCtly-mafticated food conftitutes the greater portion of the ingefta, there is abundance prefent to be returned into the cardia, while there is a deficiency of aliment in LI a fit i 128 P ATHOLOGY. a fit ftate to combine with, or to be operated upon, by the gallric juices ; which, when effe&ed, is rapidly con¬ veyed to the other extremity of this organ, by the re- aftion of the mufcular coat, from the undue diftention and the ftimulus of folid contents. Thus a double eft'efil is produced by the healthy organic contractility of this organ, when in a weakened ftate, and yielding a dimi- n 5 filed quantity of the ufual fluids ; which ftate indeed may be confidered as conftituting this peculiar affection, namely, that part of the aliment which is diflolved by the gaftric juices is conveyed towards the pylorus, while, at the fame time, the tonic adtion tending to diminifh the capacity of the organ pufh'es the lefs comminuted and indigeftible portions of food into the unrefifting cardia ; which is returned, as I have attempted to describe, in order to undergo a fecond comminution and intermixture with the falivary juices ; after which it is in a fit ftate to be conveyed to its deftination along the mucous furfaces, with the juices of which it combines, and thus permits a central portion of the rnafs to return and undergo a fimi- larprocefs. “In the curative plan purfued during the time this gentleman was under my care, the cutaneous eruption was viewed as originating in the long and progrefiive de¬ rangements of thedigeftive canal; and the ruminating affedlion, from the highly intelligent hiftory of its origin afforded me by the patient, as well as of the fenfations and connexions of the phenomena fo kindly accorded me during my attendance, was confidered as the moft ad¬ vanced and peculiarly modified ftate of dyfpepfia, or gaf¬ tric debility. “ Under the ufe of infufions made from a combination of vegetable tonics, aperients, and aromatics, with the addition of an alkaline carbonate ora carminative tinc¬ ture, and the frequent ufe of the warm bath, with fub- fequent friflion ; while, at the fame time, a deliberate maftication of the aliments, and a moderate indulgence in light and digeftible food, was enjoined ; amendment foon became apparent. After a fortnight’s continuance of this plan of treatment, the cutaneous difeafe had made conliderable progrefs towards removal, and the ruminat¬ ing affedlion, which till then had been prefent after every conliderable meal, was now very feluom experienced ; nor did any fymptoms of dyfpepfia take its place, unlefs when the injunctions regarding the mode of living and maftication of the food were not attended to, or when fubjedted to caufes operating a diminution of the digef- tive energy; then, dyfpeptic fymptoms, or even flight rumination, occafionally prefented themfelves. “ Within a few weeks, the eruption was entirely re¬ moved ; but the ruminating affedlion returned whenever the proper precautions were not obferved. Having im- prefled the mind of my patient with the neceflity of purT filing corredtly the plan I had prefcribed to him, upon the grounds that fuch an affedlion, if indulged, would gradually undermine the energy of his fyftem, he became more attentive to the ftate of his digeftive organs, and to his mode of living; and now, (March 1821.) for feveral months, he has enjoyed perfedl health, and had no re¬ turn of the ruminating adt. Having transferred, as he fays, the gratification formerly enjoyed in the fecond maftication to the firft, this procefs is now performed more deliberately ; a more complete admixture of the aliments with the falivary fluids and with the air, takes place ; while the ftomach is lefs fuddenly, and much more mo¬ derately, diftended.” Diflections have not been able to throw any light upon this affedlion ; nor can it be expedted, in the prefent ftate of our medical knowledge, that, even in the event of a violent death taking place in a ruminating fubjedl, any vifible alteration in ftrudlure could be detedled. Fa- bricus ab Aquapendente and Thos. Bartholinus were confident of finding two ftomachs, at leaft, in ruminating individuals, from the analogy of the cornuted tribes. Pyer and Morgagni ridiculed the idea, and fupported a contrary opinion, upon the ground that there were ani¬ mals that ruminated without a double ftomach. The only inftance Dr. Copland had met with in which in- fpedtion after death took place, was in the inftance of this affedlion occurring in a monk. This defection is recorded both by Jo. Rhodius (Cent. ii. obf. 59.) and alfo by Bonetus, (Sepulchretum, 1. iii.) It was made by FancifcusPlazzonus, and is thus related by Jo. Rhodius : “Monachus cum voluptate cibus ruminavir. Medici brutorum more gemino ventriculo praeditum putabant. Ipfo defundto, F. Plazzunos cefophagum reperit undi- quaque carnofum inftar mufculi, reliquis univerfi cor¬ poris partibus fe redte habentibus.” The phyficians of the feventeenth century were not much enlightened by the opening of this monk, but their dreams refpedting the exiftence of two ftomachs were henceforth diflipated. Enthufiaftsin their arduous profeflion (which all young medical men ought to be) are greatly indebted to fuch learned phyficians as Dr. Copland, Dr. Cooke, &c. for their indefatigable refearches into the early hiftories and records of the more ambiguous difeafes ; and the utility of fuch condenfed communications is greatly enhanced by the practical remarks accompanying them. Mr, G. Nefle Hill has added a cafe, and diffettion, of fimilar dif¬ eafe in a feverely-afflidted infane patient, who fell under his care in the year 1791 : he appeared to fall a victim to epileptic infanity, the refult of early indifcretion. That part of the hiftory of this young man which related to his rumination of his food, bore an exact refemblance to the onefo ably detailed by Dr. Copland. “ I examined the body, (fays Mr. Hill,) in the prefence of the venerable Haygarth, who, as well as myfelf, was much ftruck with the extreme tenuity and fmooth internal furface of the ftomach. In order the more corretly to obferve the ru¬ minating procefs, I invited my patient to dinner feveral times ; he ate with a ravenous appetite and wonderful quicknefs, but never finithed a meal withoutcommencing the ruminating procefs.” A further hiftory of this cafe will be found in the Appendix to Hill’s Effay on the Prevention and Cure of Infanity. 7. Limofis dyfpepfia, or indigeftion. The funtion of digeftion in the ftomach being performed by means of fecreting agents, which are veflels and nerves, and by mufcular fibres which propel the food downwards, ail caufes of indigeftion mud operate, 1. by difturbing the tranfmiftion of nervous influence ; 2. by difturbing the ation of fecreting veflels; or, 3. by paralyfing the play of the mufcular fibres. Now it would require little la¬ bour to fhow, that nothing can influence the one mate¬ rially without influencing the others, both on account of their reciprocal ation, and on account of the agency which foreign fubftances will produce on the other ftruc- tural elements in confequence of the deficient ation of one. Thus, if nervous influence be difturbed, fecretion will be wanting ; confequently the food will undergo chemical decompofition, will fwell and evolve gales; thus it will diftend the circular fibres of the ftomach be¬ yond their ufual fphere of relaxation, and by that means prevent the further digeftion of food. In the fame way the mufcular coat will be liable to diftention in the cafe of diminilhed fecretion, when that diminution arifes from torpor of thefecernent veflels ; and, if the circular fibres are diftended by mere quantity, that diftention will hurt the nervous power; for it is known that when muf- cles are ftretched beyond a certain natural compafs, their nerves communicate to the fenforium pain or irritation. In this way, therefore, reafoning from our knowledge of the quick communication of nervous power to and from the brain, we infer, that increafed tranfmiflion of ner¬ vous influence to the affeted organ will arife. Here fecretion will be increafed, though in early inftances probably unaltered. By this increafed fecretion, the food will be prevented from enlarging by chemical changes, and cannot therefore further diftend the cir¬ cular fibres ; while thofe forces will, in confequence of 129 PATHO the folution of the fubftance, more eafily expel it : fo that, in early accidents of this fort, the increafe of one power feems to relieve in fome meafure the deficiency of the other. This, however, can obtain but fora fhort time ; for the undue excitement of the fecreting veflels muft foon induce altered ftates of the gaftric juices ; Hates in which of courfe the latter will be deficient in fopie of the diflolving qualities. It is impoflible to Hate exactly which of, or in what proportion, tliefe powers firft under¬ go derangement. It is probable that, while in gluttons diftention of mufcular fibres is the firft ftep to diforder, in the drunkard the nervous expanfions may be firft injured, while the fecreting veflels are difordered by caufes which arife from the conftitution at large. Having ftiown, however, that thefe powers are all eflentially deranged in a manner almoft fimultaneoully, it is of little importance to attempt to trace the fubjeCl further : for it does not feem that, generally fpeaking, in the earlieft ftage of in- digeftion, the vafcular fyftem is materially implicated. We except of courfe the affeftion of the ftomach which we have noticed in our introduction, chronic gaftritis. - We have already endeavoured, on general principles, to trace the morbid affeCtions arifing from diforders of the alimentary canal : it remains to do fo in detail. We have faid that this diforder injures the other parts by nervous influence, or by the abforption and local appli¬ cation of difeafed blood. There feems every reafon to believe, that in indigeftion, when the complaint is not very violent or of long Handing, though nervous irri¬ tation may arife, the aflimilation of food into healthy blood is not materially altered : fo that difeafe traceable to indigeftion will in the firft ftages be the mere confe- quence of nervous diforder. It is important, as a prac¬ tical diftinCtion, thus to know when derangement is propagated to remote organs by nervous communication, without involving the vafcular fyftem importantly, or whether the vafcular fyftem has become deranged in con- fequence of the local application of difeafed blood, or a continuance of nervous irritation fo long kept up as to alter the contractile power of the veflels. The tracing of difeafes in this manner appears to us a matter of the ut- moft importance ; for it is notorious that many affeCtions arife from difturbance in the ftomach and bowels, which mimic or refemble idiopathic difeafes of the firft magni¬ tude and danger. Idiopathic difeafe may after a time be induced by the long continuance of the caufe juft mentioned ; but it is a practical faCt of the utmoft confequence, that, while in¬ flammation, (and that is the moft frequent form of difeafe that occurs,) arifing idiopathically, is difficult of fubduc- tion, and only to be removed by emptying the blood-vef- fels ; the fame aCtion arifing from nervous excitement thus propagated, foon fubfides when that excitement is withdrawn; and this takes place, though more rarely, even in cafes of long Handing ; in cafes where the aflimi- lative function is deranged, and morbid ftates of the fluids are exifting, the removal of thefe ftates being at¬ tended with the gradual fubduCtion of the propagated difeafe; Having detailed the caufes of indigeftion in full in our introductory obfervations on this clafs, we (hall now proceed to confider the fymptoms of indigeftion, dividing it into two ftages. The firft, in which mere difturbance of function, the digeftive, and that in flight degree, is apparent, and in which the fympathetic difeafes are vary¬ ing and unmarked; the fecond, in which that difturbance is manifeited in a marked and ferious form, in which the vafcular ftruCture feems continually affeCted, and which is generally connected with difeafed ftates of the collati- tious vifcera. The dependant ailments attached to each of thefe ftates will be difcufled under the fame heads. This divifion is however merely chofen on account of its practical utility, becaufe fome difference of treatment both of the local and conftitutional difeafe is neceflary, according as the digeftive difturbance is recent or of long LOGY. Handing ; but, in enumerating the fymptoms of this dif¬ order, it muft be confefled that no peculiar fign indi¬ cates with certainty or precifion the pafling of diforder, or the firft ftage, into that of difeafe, or the fecond; and that much careful and in fome meafure original obferva- tion is required even after the fulleft defcription on the part of the practitioner. The fymptoms of the early ftage of indigeftion are fuch as arife from chemical changes in the food, and the fimpleftchangesin the gaftric fluid : thefe are the evolution and eruCtation of various gafeous, oily, acid, or acrid, pro¬ ductions. They exift in various degrees ; butare only pre¬ fen t, however, during or after a meal ; and, when thedi- geftion is not in aCtion, littleinconvenience is experienced. It appears, however, that the trifling difturbance in the function of the ftomach may, for a certain time, produce a feeble or otherwife vitiated fecretion, without in any other way very fenfibly affeCting the functions of the fyftem. People frequently complain of a fenfe of diften¬ tion after eating, and flatulent and acid eruCtations, who, notwithftanding, enjoy good general health ; and find that even thefe fymptoms may be prevented by taking lefs food, and that of a more digeftible quality; and, if they are prudent in this refpeCt, and the conftitution is otherwife found, and not expofed to the effeCts of indo¬ lence, and other caufes weakening the nervous fyftem, the ftomach will often recover its powers without far¬ ther means. The irritating caufes are often, however, daily and hourly applied, and leave the ftomach perma¬ nently difordered by their frequency. The gaftric juice becomes probably fo altered or increafed, or fecreted at improper times, as to produce unpleafant fulnefs in the ftomach, even during its empty ftate. The bowels, whe¬ ther in confequence of the unnatural or undigefted ftate of the materia applied to them, whether fympathetically affeCted by continuity of ftruCture, or from want of a natural ftimulant exifting in the fecretion of the ftomach, become deficient or irregular in performing their office. Their fecretions likewife fuffer deviations from the healthy ftate, and are fcantily produced. The quantity, colour, or confiftence, of the faeces, are changed ; they are occafionally diftended and tenfe, efpecially lome time after eating. Difordered fecretions are manifefted in the mouth : a clammy tafte is experienced ; and the tongue is more or lefs furred, efpecially in the morning. But thefe fymptoms, the patient finds, yield to fome mild aperient, which, at the fame time, promotes the aCtion of the ftomach; and his feelings on the whole differ but little from thofe of health. He is raore apt to be thirfty ; his appetite is generally more or lefs impaired and variable ; he complains of his feet being cold ; butftill his ftrength and general appearance are but little affeCted ; and he feldom thinks it neceflary to pay particular attention to fymptoms which appear fo flight, and for the time yield fo readily. By degrees, however, they recur more fre¬ quently, and begin to be attended with fome depreffion of ftrength, which at firft is only occafional. This, in general, is the firft thing which ferioufly calls his atten¬ tion to the difeafe. The mind, if the difeafe proceed, partakes of thefe returns of languor, and the patient at length finds it difficult at all times to command his at¬ tention, and, upon the whole, that he is not capable of his ufual mental efforts. His fleep is difturbed by per¬ plexing dreams, and fometimes by fits of night- mare. In a large proportion of cafes, however, he enjoys good nights, and even thofe who are troubled with dreaming and reftleffnefs, often feel more drowfy than ufual. He now becomes alarmed, and occafionally feels a degree of defpondency. Inftead of thinking too lightly of his complaint, he often regards it in the moft ferious point of view, and cannot be perfuaded that any thing lei's than fome important derangement can produce the anxiety and depreffion by which his attention gradually becomes wholly engrofled. The derangement of the alimentary canal now pro- 4 duces 130 PATHOLOGY duces difordered funftion of the collatitious vifcera; and a change takes place which marks an important Hep in the progrefs of the malady. The alvine difcharge begins to deviate from the healthy appearance: it fometimes con¬ tains uncombined bile, fometimes it chiefly confifts of bile; its colour at other times is too light, more fre¬ quently too dark ; and occafionally, at length, almolfc black. At different times it afl'umes various hues, fome- times inclining to green, fometimes to blue; and fome¬ times it is mixed with, and now-and-then almoft wholly confifts of, undigefted bits of food. When there is much draining, it often contain^ mucus in diftinft maffes, and not unfrequently fubftances refembling bits of membrane. It frequently (eparates from the canal with more diffi¬ culty than ufual, and leaves a feeling of the bowels not having been completely emptied. We have reafon to believe that the above change and variety of colour arife chiefly from the ftateof the bile, to which the alvine dif¬ charge owes its natural tinge, being quite white when no bile flows into the bowels. It would appear that the properties of the bile are fometimes changed without change of colour; but this is comparatively l'o rare, that, if the colour of the alvine difcharge be natural, we may generally infer that the function of the liver is duly per¬ formed. Many conceive that the changes of colour in the al¬ vine difcharge are often to be alcribed more to circum- ftances in diet, and changes which the contents of the bowels undergo in their paflage through this canal, than to the ftate of toe bile ; and we have no doubt thefe caufes operate to a greater or lefs extent. The long de¬ lay of their contents in the bowels generally darkens the colour; a milk-diet produces a difcharge of a lighter co¬ lour than one conflfting chiefly of animal food, and fome vegetables and medicines communicate a certain tinge to the difcharge. With a little attention on the part of the pradlirioner, this circumftance will feldom miflead him. It mull always be kept in view, that the appear¬ ance of the difcharge often changes when it has remained for fome time out of the body. The difeafe has hitherto been what is called ftomach- complaint. It is now, from the various appearances of the vitiated bile, and the various fymptoms which arife from the irritation it occafions in the alimentary canal, what is called bilious and nervous complaint. The former of the two laft appellations has alfo arifen from the bile, of which there is fometimes a fuperabundant fe- cretion, being occafionally, in confequence of the in¬ verted a£tion of the duodenum, thrown into the fto- inach ; and there exciting naufea, headache, and bilious vomiting. The urine alfo deviates from the healthy ftate. In its tnoft healthy ftate, it is perfeffly tranfparent when palled, and remains fo after it is cool, its colour being more or lefs deep in proportion to the degree in which its con- tentsarediluted. But it is fometimes covered withavery thin oily film, which appears to arife from an imperfeit ftate of the affimilating procefs. Sometimes alfo it is lim¬ pid, and parted in unufually large quantities, more fre¬ quently fcanty and too highly coloured. It is then moll apt, as we ftiould ft priori expert, to depofit fediment, unlefs fome degree of fever prevail, when it often either depofits nothing, or a little of the red fediment. A remarkable fympathy between the ftate of the kid¬ neys and inteftines is often obferved in indigeftion ; the urine remaining fcanty and high-coloured, when the bowels are conftipated ; and flowing freely, and of a paler colour, as loon as a free difcharge from them has been obtained. Even in thofe dropfical affections which fupervene on this difeafe, it is common for all diuretics to fail, when the bowels are conftipated, and for the ope¬ ration of cathartics alone to be followed by a free dif¬ charge from the kidneys. The copious flow of urine which fometimes attends indigeftion, feems frequently to arife from a failure in the aCtion of the Ikin, as appears from fome of the experi¬ ments juft referred to. The kidneys and Ikin feparate the fame fluid from the blood, and a failure of fecretion from the latter is often compenfated by an increafe of that from the former, if they have not by fympathy par¬ taken too much of the ftate of the Ikin. Thus, in dyf- peptics, an unufual application of cold to the furface, when the powers of the lyftem are not able fo to re-aCt as to fupport the due aCtion of the Ikin under it, frequently occafions an increafed flow of urine. The fame caufe often occafions a greater difcharge from the bowels. It particularly demands attention in this difeafe, that, al¬ though the increafed difcharge from the bowels in the inllance before us is of a watery nature, when the Ikin has, from the ftate of that difeafe, become uniformly languid, the increafe is often in the folid, as well as liquid, con¬ tents of the bowels. On the fame principle, the quantity which paffes from the bowels of delicate children when the Ikin has become dry and Ihrivelled, is often aftoniffi- ing, and that even when little nourilhment is received; as if not only what ought to have parted by the Ikin, but a great deal of what had been inhaled by this organ, were depofited in a folid form in the alimentary canal. What is here faid is well illuftrated by the cafes which we detailed of very great eaters, in whom the alvine dif¬ charge was no greater than in other people, but the fe¬ cretion by the (kin was found much more copious. The fenfible change in the appearance of the alvine fe- cretions in indigeftion, is generally attended with fome change in the other fymptoms. The ftomach is more apt to be oppreffed after eating, the patient often obferving that he feels as if there were not room for what he had taken. The bowels are more frequently variable, diar¬ rhoea often fupervening without any evident caufe, almoft uniformly followed by fits of conftipation. Thefe, the patient finds, cannot now be removed by the Ample me¬ dicines which at firft reftored due action to the bowels ; larger dofes or more active medicines are necertary, and their effeft correfponds with the previous ftate of the bowels. The difcharge is generally unfatisfa&ory, fomething feeming to be retained. It is very often wa¬ tery or iemi-fluid, mixed with mucus, and fometimes ftreaked with blood ; and, after it has been repeated, often chiefly confifts of mucus and a little blood, the paf- fing of which is attended with much gripingand bearing- down, and followed by a conftant defire of further eva¬ cuation. The patient takes more medicine with the hopes of a freer eft'eft ; but he thus often increafes the {training more than the difcharge. After this ftate of irritation has continued to recur for a great length of time, a degree of permanent fpafmodic ftridfure fometimes appears, which gives a tape-like ap¬ pearance to the alvine difcharge. In the mean time the patient is haraffed with a variety of other fymptoms, arif- ing from the irritation occafioned by the morbid con¬ tents of the alimentary canal ; increafing languor, pains of the ftomach, more frequently of the bowels, and parti¬ cularly of the lower part of the bowels, fometimes conti¬ nued, generally of the griping kind ; a fenfe of heat, or, as the patient often calls it, burning, referred to the ftomach, and now-and-then extending to the bowels, (which fometimes proves the molt obftinate and diftreff- ing fymptom of the difeafe;) or of weight in the right hy- pochondrium or lower part of the abdomen, with unufual diftenfion of the former, fometimes difappearing in a day or two, particularly after freer evacuations, and return¬ ing again, at other times more ftationary ; a more foul and clammy tongue, naufea, more rarely vomiting, a de- preffion of llrength, which fometimes, particularly after the unfatisfa&ory operation of cathartics, almoft amounts to fyncope, and a defpondency that is hardly equalled in any other difeafe. As thefe fymptoms proceed, others, the confequence of the fympathy which exifts between the ftomach and other parts of the fyftem, gradually ftiow themfelves. Thefe are 131 PATHOLOGY. are different in different cafes ; pain of different parts, and other complaints, of the head, affections of the fight, the hearing, fmell, or tafte. The voice and articulation are fometimes varioufly affeCled. The patient is diftreffed with' fpafms of the trunk or limbs, numbnefs, and even temporary lofs of power in the latter; and feelings of endlefs variety are defcribed, as fometimes in one part of the body, and fometimes in another. By a conftant recurrence of fuch attacks without being uniformly ill, for the rapidity with which the patient rallies is often as great as that with which he is fubdued, he is gradually rendered unfit for the aCtive duties of life. This preys on his mind, increasing the defpondency which makes a part of his difeafe, and which in its turn, by further debilitating the digeftive organs, aggravates all the fymptoms. Thefe organs being no longer in a proper ftate to fupply due nourishment, the body becomes ema¬ ciated, and more permanently feeble, the ftrength by de¬ grees rallying lefs readily and lefs perfectly after the fre¬ quent returns; and what was at firft only a temporary depreffion from a debilitating caufe affeCling the nerves of the alimentary canal, is gradually changed into real debility, the countenance, which is almoft always a fure index of what is palling internally, becoming pale and haggard. The patient, often from an early period of indigeftion, feels fome uneafinefs on lying on the left fide; more rarely this is the cafe with refpeCt to the right fide. In the progrefs of the difeafe, lying on either fide becomes un¬ comfortable, and, in its advanced ftages, the only eafy pofition is on the back, with the (boulders a little raifed, and generally inclined to the right fide. The tongue and other parts of the mouth are varioufly affeCted from the commencement. Their Secretions be¬ come more and more thick and clammy, the former being covered with a white or brownifli mucus, which alio more or lefs adheres to, and irritates, the fauces. Some¬ times all thefe parts are more or lefs parched and ftiff ; at other times the faliva is morbidly thin and copious, the tongue being cleaner, but often of a whitilh and fouden appearance. In protra&ed cafes, when the fymptoms have been rather obftinate than fevere, and confiderable debility has come on, this fymptom is often very trouble- fome, the faliva frequently running from the mouth. In the advanced ftages of the more fevere cafes, there is often a vifcid frothy fecretion from the fauces, while the mouth in general is drier than ufual, which forms a very promi¬ nent feature of the difeafe. The patient isconftantly hawk¬ ing up this matter, particularly after eating, and will tell you that all his food turns to phlegm. This difcharge is fometimes fo great and haraffing as to prove the moft diftrefling fymptom, and feems not a little to add to the debility. In fome cafes the tongue, in the more ad¬ vanced ftages, becomes clean, ihining, and morbidly frnooth, and at length affeCted with aphthae. This ftate of it is feldom oblerved except when a confiderable de¬ gree of fever has fupervened, which is not uncommon at thefe periods. The Ikin, in protraCted cafes, often becomes dry, lhri- velled, and fometimes, at length, almoft fcaly, and the hair is parched and inclined to ftand on end; the whble furface is cold, the patient is conftantly hanging over the lire, and even experiences frequent fits of chillinefs approaching to Ihivering. He bears all extremes of tem¬ perature ill, being as much oppreffed by a very high tem¬ perature as he is chilled by a low one. Wounds heal lefs readily than ufual ; and the Ikin is not unfrequently affeCted with a troublefome itching, which often fliifts its leat ; or with nettle-ralh, herpes, and other fpecies of eruptions ; and even ulceration fometimes fupervenes without any evident caufe. Befides the more tranfitory fymptoms in the head, which have been mentioned, there are often marks of an habitual undue determination of blood to the brain, pro- yoi. XIX. No. 129s. ducing languid inflammation of the eyelids, tinnitus au- rium, and occafionally throbbing of the temples. Some are oppreffed with drowfinefs, almoft approaching to ftu- por ; others with almoft conftant pain more or lefs fevere, fometimes in the back of the head, more frequently in the fore part ; others are fubjeCt to giddinefs, and fome even to fudden fits of infenfibility. The thoracic vifeera are often particularly affeCted; not unfrequently dyfp- ncea fupervenes, and the patient is fometimes haraffed by a dry and irritating cough, or with fits of palpitation. When expectoration attends the cough, it is generally difficult, but brings confiderable temporary relief. It deferves notice, that, in this ftage of the difeafe, he more frequently complains of pain in the left than in the right fide; but the feat of the pain is very various; not un- ffequently it is -chiefly in the back, about the Ihoulders, fometimes attended with itching, and in the limbs, more frequently in the legs than the arms. Irregularity of pulfe and fyncope are not unufual fymptoms; and are much to be feared when combined with other charaCter- iftics of angina pedoris, as they fometimes produce, in the fecond ftage of indigeftion, organic difeafe of the heart. Pain and tendernefs of the mufcles of the cheft is alfo frequent; and, when this occurs, the patient feems worfe at night, and turns in bed with difficulty and pain. The above hiftory of the firft fymptoms of indigeftion we have borrowed from the accurate work of Dr. Wilfon Philip. It remains to trace the fympathetic derange¬ ments which grow out of this ftage. It is to be premifed, that, when nerves are irritated, and fympatheticaliy affeCt diftant parts, the latter, how¬ ever influenced, return to their natural ftate when the nervous excitement is removed. Of cqurfe, as the altered ftate of the nervous influence will accelerate or impede the contraftile powers of veffels, the phenomena of in¬ flammation may occur, and the fame excitement conti¬ nued may produce the confequence of inflammation. It follows therefore, that, if the nervous expanfion of the ftomach be irritated, and caufe diftant diforders, we may cure thofe by removing that irritation : but if, from its long continuance, or from the nature of the affeCled ftruChire, irritation degenerates into inflammation, we have further indications to fulfil. Of this fact experience convinces us every day. We have to correct the morbid ftate of the fecondarily- affeCled part, as well to remove the firft caufe. The firft derangements are what we have to confider at prefent. The fubjeCt has been ably treated of by Dr. Marlhall Hall, in his Effay on the Mimoses ; a name which, as its origin implies, defignates a ftate which mi¬ mics, or refembles, other difeafes. The above-mentioned author has however ufed this term in a very extended fenfe; he has included in it many difeafes where idiopathic diforder had become efta- blifhed. For our own part, we (hall reft riCt the term to thofe affeClions which are propagated by nervous in¬ fluence, which do not implicate permanently the vafeu- lar ftruCture, and which fubfide on the removal of indi¬ geftion. Ufed in this fenfe, it charaCterifes the affeCtion in queftion with great force and faithfulnefs ; and con¬ veys a clear idea of the difference which we find in the mere fympathetic diforder, and thofe more ferious af¬ fections which, arifing from longer-continued or feverer forms of dyfpepfia, or from thefe and the morbid predif- pofitions of their own feats, require mixed methods of treatment : i. e. fuch as immediately influence the circu¬ lating as well as the digeftive funCtion. But, ere we enter on this branch, we mull again remind our readers, that we confider Difpr.pfia, in all its immediate as well as remote fymptoms, as a difeafe incapable of regular ar¬ rangement. In proportion as one or other of its nume¬ rous caufes are applied, in proportion as the remedial in¬ dications are wrong or mifplaced, will it appear in the marked and fevere characters of the fecond ftage, without Mm exhibiting 132 P A T H O exhibiting any traces of what we have called its firft. And, belides this, if morbid predifpofitions are exiftent in the remote ftruStures, idiopathic difeafes will occur in them, as foon as the nervous excitements we have juft fpoken of are applied to them ; and thus (how the fallacy that will attach to the unreftriSled notion, that the fym- pathetic diforders of the firft ftage of indigeftion are fo purely nervous as not to produce real topical inflamma¬ tion in fome cafes. We are convinced however, that, as the divifion we have made will be found good in the ge¬ nerality of cafes, it is better to adopt it than run the various remote and local fymptoms of indigeftion into one another without order. The anomalies we (hall notice will eafily be remembered ; and, though their confufion (if we may ufe the expreflion) muft undoubt¬ edly take from the uniformity of arrangement, we confider that far better than that we (hould fail to repre- fent with fidelity, and to the beft of our knowledge, the true phenomena of nature. To return, however, to the mimofes. The common and diftinguiftiing fymptoms of thefe affections are, that, while in idiopathic difeafe a peculiar and perpetual ftate of diforder is found, or at lead a ftate which exhibits re¬ gular intermiflions and paroxyfms, thefe complaints ex¬ hibit no regularity whatever; that, while in idiopathics one great and predominant fymptom arrefts the atten¬ tion of the patient, and often of the practitioner, in this the difeafe is complicated, afteCts for a time one ftruCture, then another; and indeed manifefts all thofe appearances which we (hould expeCt in merely excited dates of the nerves, without inflammatory aftion. As it is impoflible, on account of the multiplied groups of fymptoms which may occur in thefe affections, to detail all their forms, we (hall confine ourfelves to a general review of their nature as they occupy the nerves of the grand fyftems, or parts. The firft we (hall confider is the brain. Here we find many dates arifing from this caufe, very clofely refem- bling difeafe of the vafcular fyftem ; and it muft be re¬ marked indeed, that the latter ftate is more frequently induced by nervous excitement in the brain than in any other part. The moft common fymptom is faintnefs. This is the moft ordinary nervous excitement, fince it occurs in the (impleft derangements of the nervous power. The circle of fympathies in this cafe, fudden and fimultaneous as it undoubtedly is, is complex. The ftomach afteCts the head, the head the function of refpi- ration, the latter the heart ; and, this laft failing duly to impel the blood into the cerebral ftru&ure, /amring takes place. A further confequence of this ftate is languor of themufcular fyftem from torpid circulation in the brain ; and the fame torpidity will likewife influence thefecret- ing powers. The irritant of the ftomach being however removed, all thefe effeCts ceafe. But, where acontinued dyfpeptic ftate exifts, thefe effeCts become more perma¬ nent, which readily explains the fainting, languor, tre¬ mor, &c. which are attendants on the firft ftage of indi¬ geftion, and which are eafily removed with that com¬ plaint. With regard to the languor, it is to be remarked that between languor arifing (imply from the caufe we are fpeaking of, and between that which fupervenes in the more advanced ftate of indigeftion, a great difference exifts : for, while the firft merely depends on the inter¬ ruption of nervous influence, the latter probably owes its prefence to fome alteration in the contractile power of the mufcular fibre. However this may be, the diffe¬ rence between real and apparent debility is allowed by the beft practical writers. We have no knowledge why ftomachic irritation ap¬ plied to the brain caufes fometimes one, fometimes ano¬ ther, kind of diforder of that organ ; why one man feels temporary blindnefs, another debility, anotherdelirium, and fo on. We have certainly no means of knowing whether this takes place becaufe the applied irritants aCl only on particular parts of the cranial ftruCture, or whe- L O G Y. ther the nature of the irritants alters the nature of the fympathetic difeafe. We have good reafon to infer both of thefe circumftances. The firft, however, is a fpecula- tion of no ufe in practice : the latter may be fo in a (light degree, becaufe we (hall find that, in the inflamed ftate of the ftomach, the inflammation will more readily arife in the brain ; while, in the cafe of mere nervous irrita¬ tion, that ftate will be lefs frequently found. The moft formidable appearances which are complicated with irri¬ tation of the gaftric nerves are thofe of epilepfy and apo¬ plexy. Slight degrees of hypochondriafis, too, likewife occur ; but thefe are unfrequent in the firft ftage of dif- pepfia. A threatened attack of apoplexy of this kind is often obviated by the exhibition of a ftrong purge. Where it once takes place, or where the pulfe is the fame as we commonly find aflociated with that ftate, bleeding, &c. will of courle be had recourfe to likewife.' We mention this here, to remind the reader of the great neceflity of procuring evacuations by emetics and purga¬ tives when this form of apoplexy exifts. It is this kind of apoplexy which fo often and fo fatally attacks perfons retiring to bed after a hearty /upper ; an occurrence la¬ mentably frequent in the daily records of our times. A fudden attack of epilepfy has often been induced by the fame caufes. The purgative treatment is extremely be¬ neficial, as well as in dates of infenfibility and delirium, lofs of memory, blindnefs, &c. fuddenly fupervening to thefe digeftive derangements. A peculiar ftate of the brain is often induced by irri¬ tation in the alimentary canal, which has been called by Dr. Nicholl, the firft author who has given a clear view of it, “ Erethifm of the brain.” According to the ex¬ perience of that author, it feems that it chiefly occurs in children. Such a (lute, however, is often met with in patients afflicted with indigeftion at more advanced ages. Dr. Nicholl thus deferibes it : “ There is a ftate or condi¬ tion of the cranial brain in infants, which may be called a ftate of irritation, an irritated ftate, or, in one word, erethifm. What this peculiar condition of the cerebral ftructure is, I cannot explain. It is a ftate diftinCt from that which is called inflammation of that ftruCture, for it may exift without any perceptible increafe of the quan¬ tity of blood that flows through the cerebral blood-vel- fels ; it is a ftate under which inordinate effeCts arife from ordinary impreflions upon different parts of the nervous fyftem. In its perfect form, and under a high degree of it, it is a highly fenfitive condition of the cranial brain, a condition the very reverfe of that under which fleep occurs. Under fuch a condition of the cranial brain, the child is wakeful, fcarcely ever (leeping ; it is attentive to every found, and to every object of fight; its temper is irritable; the retina is highly fenfible to light, fo that the child winks if its face be turned towards the window, or towards a candle ; the pupil is, in many inftances, more or lefs contra£led ; but this is not always the cafe. The limbs are much in aCtion ; the head is often moved about, or is (haken from fide to fide; the child cries without any apparent caufe, and it is foothed only by tofling it, by carrying it about, by putting it to the breaft, or by letting it fuck the cheek of the nurfe, or its own fingers ; the fecretion of tears is, in many inftances, increafed, caufing fuffufion of the eyes, and rednefs of the edges of the tarfi; the fecretion of the fchneiderian membrane may be increafed, caufing a fluffed ftate of the nafal paffages, producing fneezing, and exhibiting the appearance of that ftate which is popularly called a cold. The bowels are, in many cafes, relaxed; yet no difordered ftate of the ftools may appear. During fuch a ftate as I have de- feribed, there may be a degree of animation, and a quick- nefs of obfervation, much beyond what are commonly met with in children of the fame age : fo that, although a morbid condition of the cranial brain be prefent, the child may be confidered as particularly healthy, on ac¬ count of its being wakeful and lively, and fenfible to the moft; PATHOLOGY. molt trifling impreflions. But it frequently happens, that an attentive obferver may detect other fymptoms : the child may ftart in its deep ; it may be very readily awak¬ ened ; when awake, it may Hart at the flighted noife, as at the ihutting of a door, moving a chair, palling the finger over the wicker-work of its cradle, or on being flightly moved, or touched gently; a fudden frown may pals over the forehead, and may quickly difappear; the eyes may be clofed irregularly, or alternately, or a winking of one eye, or frequent winking of both eyes, or a firm clofing of both eyes, may be from time to time de¬ tected ; the hand may be raided frequently to the head ; the child may cry, without any evident caufe, as if it were pricked with a pin ; at other times, it may Ihriek ; the fills may be clenched, the thumb being bent in, and laid flat acrofs the palm of the hand, the fore¬ arms being bent upwards on the arms. Should a iimilar condition of the fpinal brain be prefent, the child may be bent backwards, prefenting a Hate of opijlhotonus ; its legs may be drawn up, while the head is thrown backwards.” There is another form of infantile erithifm characterized by want of animation, fretfulnefs when roufed, want of fleep, and yet “ a ftate that can hardly be called waking ;” indifference to furrounding objeCls, pallor and chillinefs of the body, rolling of the eyes, plaintive moaning or Ihrieking, jactitation of the hands, and other minor fy tnp- toms ; which our author denominates torpid erelliifm. Scrofulous children have generally the greateft ten¬ dency to cerebral erithifm ; and, where this tendency exilts, the flighteft irritation of the nervous fyftem will call it into aCtion. In the milder forms and earlier ftages of this affeCtion, the fymptoms which it produces may be great wakefulnefs, great fenfibility to flight impreflions, with reltlelfnefs and high animation. It is to be remarked, that irritants applied to any of the nervous expanfions may produce eretliifm, fo that it is juft poflible that it may arife independent of gaftric or intellinal diforder. It is to be noticed likewife, that this ftate is extremely liable to run into inflammation of the brain and hydrencephalus, wdiich it fometimes refembles in the clofeft manner, particularly where worms are the irri¬ tants applied. The refpiratory function is often much difordered by dyfpepfia. Paroxyfins of oppreflive dyfpnoea come on, which very clofely refemble afthma ; fo clofely indeed, that it is only by attending to the increafe of the fymp¬ toms after eating, to its hiftory, and the ftate of the ali¬ mentary canal, that we can eftablifli a diagnofis. And it is not improbable that afthma properly fo called, fre¬ quently, if not generally, originates in a complication of this nature; but is afterwards continued, or repeated, either from a degree of diforganization induced in the heart or lungs, from the influence of the external caufes of afthma, or from the caufes of indigeftion. The affeStions of the heart which occur in confequence of the Mimofis acuta, are fluttering, palpitation, and irre¬ gular aCtion. Fluttering and palpitation of the heart are amongft the tnoft frequent fymptoms. To eftablilh a correCt diagnofis in the feverer cafes it will be neceffary to watch the effeCt of the remedies in removing this diforder. The palpitation of the heart, if a confequence and effeCt merely, will be mitigated or removed with the original affeCtion. In the lefs fevere form of this.complaint, the difcrimination mull be principally founded on a cautious obfervation of the effeCt of bodily exercife on the aCtion of the heart, when the fymptom of palpitation is other- wife abfent, and when the patient is leaft indifpofed, and on the continued hiftory of the complaint. In difeafe of the heart, it is bodily exertion and mental agitation which renew. and recall this dreadful difeafe; but, in the com¬ plication of dyfpepfia with palpitation, the patient, if not prevented by weaknefs, can, at the time when the hur¬ ried movement of the heart is abfent, run pretty rapidly, or walk up flairs, without fuftering more than is ufual ; 133 and periods occur when he has puffed feveral days, weeks, or months perhaps, without experiencing the palpitation. In a difeafe of the heart, thefe circumftances are by no means obferved ; the uneafy fenfations which accompany this difeafe, if abfent at times, are always excited on any corporeal exertion; and, moreover, difeafe of this organ is in general highly characterized, and diftinguifhed from certain fymptomatic diforders of its functions, by the permanency of the affeCtion ; by its invariable aggrava¬ tion on mufcular exertion, as well as mental emotion and by the particular relief obtained at firft from blood¬ letting. Difeafe of the heart, although its fymptoms may be mitigated at one period and aggravated at another, is however permanent ; the fymptoms are never entirely abfent ; and they may at any time be renewed, in an ag¬ gravated form, by mufcular exertion. In dubious cafes, the patient may be made to run up fairs ; the fymptoms of an organic difeafe of the heart are invariably aggra¬ vated by this mufcular exertion, the pulfation of the heart becoming violent, the pulfe perhaps irregular, the refpiration exceedingly difficult, &c. circumftances not equally obferved in iymptomatic derangements of the functions of this organ, unlefs when they are attended with great debility. There is almolt always, too, great but tranfitory relief from blood-letting, in a degree not obferved in the fymptomatic affeCtions. The affeCtions of the mufcular fruBurc , independent of the debility, &c. juft noticed, are partial paralyfes, fuch as are termed fpafmodic, among which tetanus often ap¬ pears. The belt illuftration of this ftate is afforded by the hiftory of hyfteria, when it arifes from gaftric irrita¬ tion. The abfurdity, however, of applying the term hyf- tcria to a difeafe which does not at all implicate the ute¬ rine fyftem, and which even affeCts men, is obvious enough : we (hall therefore ufe the term of Dr. Hall, viz. Mimofis urgens, and referve the term hyfteria to defignate fymptoms of uterine irritation. The Mimofis urgens, then, is generally denoted by combining fome coniider- able emotion of the mind, denoted by fighing, fobbing, tears, or laughter, with a fenfe and exprellion of fuffoca- tion, and with fome urgent affeCtion of the head, heart, refpiration, ftomach, or mufcular fyftem, and a peculiar and high degree of hurry, and apparently imminent danger. Of the Mimofis urgens there are three forms, the mild, the fevere, and the inveterate ; and there are molt nume¬ rous modifications. i. The mild form of the Mimofis urgens fubfifts as a ten¬ dency to alternate high, and low fpirits, to fits of laugh¬ ter, to frequent deep fighing, and to tears. A fit of laughter, or of crying, fometimes takes on an aggravated character; the laughing, or the fobbing, becomes immo¬ derate, convulfive, and involuntary, and there is fre¬ quently a peculiar fpafmodic chucking in the throat. The countenance changes, being alternately flulhed and pale, and denoting great anxiety. There is frequently an urgent difficulty in breathing, with much rapid hea¬ ving of the chelt. Sometimes a dry, fpafmodic, and vio¬ lent, fit of coughing occurs. There is generally a fenfe, an appearance, and an urgent fear, of impending fuffb- cation. In different inftances there is palpitation, hic¬ cough, retching, or borborygmus. The patient is de- fpondent, and aggravates all her fufferings. a. The fevere form of the Mimofis urgens confifts in a various attack, catenation or combination of the follow¬ ing fymptoms : The commencement, courfe, or termina¬ tion, of this and indeed of every form of the Mimofis urgens, is generally marked, and the cafe diftinguiflied, by the figns of fome inordinate mental emotion, (joy, grief, or other affeCtion,) which conftitute the moft cha- raCteriftic fymptoms of this diforder. The attack is fre¬ quently ulhered in by an unufual appearance of the countenance; a rapid change of colour, rolling of the eyes, diftortion or fpafmodic affeCtion of the face. The extremities are apt to become very cold. A ftate of gene- PATHOLOGY. 134 ral or partial, of violent or of continued, convulfion, or of fixed fpafmodic contra&ion, takes place, and difplays every poflible variety in mode and form. The fevere form fometimes confifts chiefly in a general or partial pain and throbbing of the head. Occafionally this pain is confined to one particular fpot, and is fo acute as to have ob¬ tained the appellation of clavus hyflericus. Sometimes there is intolerance of light and noife ; fometimes a ftate of ftupor; fometimes delirium. The refpiration is fre¬ quently much affe&ed : an oppreflive and fuft’ocative dyfpncea takes place ; or the breathing is rapid, anxious, and irregular; or varioufly attended with fobbing, figh- ing, much rapid heaving of the cheft, and fometimes with a fpafmodic a6tion of the diaphragm, inducing a pe¬ culiar elevation of the abdomen, or an equally-peculiar fuccuflory movement of the trunk in general ; fome¬ times the refpiration appears to befufpended altogether for fome time, the pulfe continuing to beat as before. A crowing noife, or fcreaming, is apt to occur in this affeftiorx. There is, occafionally, hoarfenefs, or even an entire lofs of the voice, continued for fome time. There is fometimes a painful, violent, dry, hoarfe cough, conti¬ nued, or recurrent in paroxyfms. There is occafionally acute pain of the cheft or abdomen. Palpitation of the heart, and fyncope, are alfo ufual affeftions. The pulfe is otherwife little aft'efted. There is frequently an ur¬ gent fenfe of fuffocation, accompanied with the feeling of a ball afcending into the throat; this fymptom is fo peculiar as to have obtained the denomination of globus hyjlericus, and is confidered as diagnoftic of this affe&ion. Hiccough, and violent fingultus ; retching and vomiting ; the fenfe of a ball rolling within the abdomen ; borbo- rygmus ; a peculiar great and fudden tumidity of the ab¬ domen, apparently from flatus ; conftipation, & c. 3. The inveterate form of the Mimofis urgens (id enim vitium quibufdam feminis crebro revertens perpetuum evadit) confifts fometimes in an almoft-perpetual agita¬ tion of fome part of the body, the limbs, the refpiration, the throat, or the ftomach ; and fometimes in a ftate of continued contraction of the hand or foot, or of fome other part. In different inftances too, there is a conti¬ nued ftate of nervous agitation from the flighted noife or other caufe ; of paralytic, epileptic, or fpafmodic, dif- eafe ; or of imbecility of the mind. In fhort, this affec¬ tion is characterized, by affeCting in the fame or in dif¬ ferent inftances, fingly or conjointly, all the feveral fyf- tems which conftitute the human frame; the organs of animal and of organic life ; the different fets of mufcles, voluntary, involuntary, mixed, and fphinCter; the fa¬ culties of the mind, and the emotions of the heart; the functions of the head, the heart, the ftomach, &c. “It is in thus viewing the Mimofis urgens, that the diagnofis is often formed between its different and very-various attacks, and other affeCtions having a different origin, but of which it is the imitator, nam nullos fere non amu- latur ex iis affeCtibus quibus atteruntur miferi mortales.” Hall, p. 162. The diagnofis in Mimofis urgens is founded partly on the peculiar and different appearance of the particular cafes, and partly on the precurfory, concomitant, or fuc- eefiive, occurrence of fome unequivocal fymptom, and efpecially of the appearances of mental emotion, &c. be¬ fore noticed ; and of hurry and apparent urgency of complaint in general. It is, in particular, in this manner that the paroxyfm of convulfion in the Mimofis urgens is to be diftinguiflied from epileptic or puerperal convul- fions ; for, though the appearances are very fimilar, there is probably fome fymptom of mental emotion, or fome appearance peculiar to the Mimofis urgens, efpecially the hurried and heaving refpiration, or fome circumftance in the hiftory of the attack, which may lead to the diag¬ nofis. Otherwife the phyfician mult wait awhile, and watch the courfe of the affection, and the fucceflion of fymptoms; in this manner fome fymptoms decidedly pe¬ culiar to the Mimofis urgens will occur to prompt the diferimination. In the epileptic or puerperal convulfion, there is an abfence of thefe fymptoms of mental emotion, as joy, grief, &c. and the patient feems to be rather a prey to fome power which exerts a violent empire over the fource of fenfe and mufcular motion. The Mimofis urgens may excite alarm ; but the epileptic or puerperal convulfion prefents a far more dreadful afpeCt; the fa<;e perhaps becoming deeply flufhed and livid, with foaming at the mouth, more fhocking diftortions of the counte¬ nance and of the body, and a very different and a more ferious affeCtion of the refpiration. By iuch means thefe affections will generally be diftinguiflied. The occurrence of delirium is not very frequent ; but Dr. Hall has witnefled it repeatedly. The cafe is identi¬ fied by the occurrence of fome fymptoms peculiar to the Mimofis urgens. The occurrence of ftupor as a form of the Mimofis urgens is by no means unfrequent. Dr. Hall relates the following x;afes : “Some time ago I received an urgent call to vifit a poor woman faid to be in an alarming ftate of infenfibility. She was without fenfe or motion, but, in other refpeCts, unafteCted with any particular fymp¬ tom. The medical attendant had prepared his lancet to open a vein in the arm. In a Ihort time, however, tire patient recovered herfelf, and manifefted fymptoms which are peculiar to the Mimofis urgens. — In another cafe which occurred in an aged woman, a vein had been opened, under the idea that fhe was afteCted with apo¬ plexy. Some fymptoms of an anomalous kind occurred, and file became affeCted with an unequivocal attack of the Mimofis urgens. — In fimilar or dubious cafes it is proper to wait, and obferve the change of fymptoms; and parti¬ cular inquiry mull be made into the hiftory, mode of at¬ tack, &c. of the affeftion. Perhaps the patient foon opens the eyes, fighs, is aft'eCted with dyfpncea, or burfts into tears. In general fome unexpected and anomalous fymptom occurs, to denote the nature of the aft'eCtion.” In pain of the cheft in Mimofis urgens, the countenance is expreflive of great anxiety, hurry, and agitation ; and the noftrils are moved with rapidity. The patient com¬ plains much, manifefts great impatience, is urgent for relief, and calls out from the pain. The pain of the cheft is extremely acute, and the part affeCted is de- feribed as excruciatingly tender on being touched, and the hand applied to it is ufually puftied rudely away. With or without the pain of cheft, there is often an ur¬ gent dyfpncea; the refpiration is rapid, hurried, with much oharaCteriftic heaving of the cheft, fometimes with great and rapid movements both of the cheft and abdo¬ men, and often with a peculiar hifling noife. Cough occurring as a form of the Mimofis urgens, comes-on in continued fits ; it is frequent, hoarfe, and hifling; “ seger creberrime tuflit, fere fine intermiflione, nihil prorfus expeCtorans.” Hall, 176. The affeCtion of the diaphragm in the Mimofis urgens is attended by the moft acute pain in the epigaftric region, extending to each fide along the falfe ribs, and to the back ; it is augmented occafionally by moving, or by the aCtion of the diaphragm in refpiration, and caufes the pa¬ tient to cry out. The refpiration is irregular, perhaps performed by the cheft alone ; the noftrils move, the face is fometimes fluftied, and there is often ftiedding of tears. Thefe cafes are diftinguiflied from inflammation, by the occurrence of lymptoms peculiar to the Mimofis urgens ; the mode of attack, which is fudden ; and the general afpeCt of the cafe, which is hurried and urgent; con- trafted with the ufual charaCteriftics of inflammation, The imitation of croup by the Mimofis urgens takes place in fuch a manner as to deceive a curfory obferver. The refpiration and cough have precifely the character of thefe fymptoms as occurring in inflammation of the tra¬ chea. It is by inquiry, waiting, and by cautjoufly ob- ferving the cafe, that the diagnofis is to be inftituted. On inquiry, the attack will probably be found to have been marked by fome fymptom or character of the Mi- 5 mofis PATHOLOGY. moils urgens ; or, by waiting, Tome fuch fymptoms may occur to develope the myftery. The cafe is fometimes fo urgent as apparently to demand an operation to pre¬ vent an impending fuffocation. We quote the following cafe: “ In a young woman, aged fifteen, the firft fymp- tom which arrefted the attention was a ftridulous found of the refpiration ; and circumftances conduced to render an attack of an inflammatory nature probable. She had been conveyed through the cold air, and appeared to be livid from cold. On being feen in bed, however, the nature of the difeafe became obvious, from the prefence, then, of globus ; from the hiftory, by which it was alcer- tained that other fymptoms of the Mimofis urgens had oc¬ curred; and from the abfence of any affection of the pulfe. The patient was fpeedily relieved by the opera¬ tion of a purgative medicine.” Hall, 177. The pain of the abdomen in the Mimofis urgens is at¬ tended with great urgency of complaint; much anxiety and fuffering; an extreme tendernefs to the flighted: touch, rather than under p re flu re ; an hurried and irre¬ gular ftate of breathing, &c. The countenance is ex- prefiive of an urgent anxiety 5 the patient is reftlefs, im¬ patient, and irafcible, and pulhes the hand, although gently applied to the abdomen, rudely away; the gene¬ ral furface, and the pulfe are, at the fame time, little af- fefted ; there is fometimes vomiting, or a fort of retch¬ ing; the bowels are generally cGnftipated. The hic¬ cough or the retching is fometimes of the moll violent kind, and is apt to be long continued. Dyfury, or re¬ tention of urine, is alfo common as a form of the Mimofis urgens. Its duration is ufually (hort. But it has conti¬ nued occafionally for a long period. It is diftinguilhed by being combined with other fymptoms of this affection. It mu ft not be forgotten that the ftomach, when its contents irritate the nervous expanfions, and the irrita¬ tion is propagated to the brain, that organ re-ads on the Itomach, and produces pain and fpafm in various parts of the alimentary canal, which are not topically difeafed : as for inftance a flight contradion of the return, of the oefophagus, fpafm of the gall-dud, mtelena hasmatenefis, See. But thefe are generally fo obvioufly connected with the prefence of dyfpeptic lymptoms, that we need not take particular notice of them. Of the Second Stage of Difpepjia. — The firft ftage of in- digeftion having continued for fome time, or an erethe- matic inflammation of the ftomach, or any of the various caufes capable of inducing inflammation, being prefent ; the fecond ftage of indigeftion makes its appearance. The palling of the firft ftage into this is denoted by va¬ rious figns ; fome taken from the nature of the gaftric or inteftinal derangements, but chiefly from the nature of the fympathetic irritations. With refped to the former, the ftomach betrays fymptoms of chronic in¬ flammation; and the inteftinal excretions, hitherto irre¬ gular, for the mod part affume deficiency of colour or confidence of a more permanent kind. The ftate of ner¬ vous excitation, in which fympathizing parts have been long retained, brings on a more permanent change in the fanguineous ftrudure, or fecretion becomes difturbed in the fame continued manner in particular parts. The topical affections are lefs changeable and varying. The mind, lofing the petulant nervoufnefs of the firft ftage, feels all the imaginary hurry and the anxiety of hypo- chondriafis; the fymptoms are lefs under the control of medical treatment ; every thing, in a word, afl'umes a more fixed and continued form. The great pathogno¬ monic fign confiftsin a permanent tendernefs, on preflure, of the foft parts clofe to the edge of the cartilages of the falfe ribs on the right fide, after they have turned up¬ wards to be joined to the fternum. This fpot is often very circumfcribed, and always lies about half-way be¬ tween the end of the fternum and the place at which the loweft of the cartilages begins to afeend ; and the carti¬ lage itfelf near the tender part often becomes very tender, not unfrequently indeed much more fo than the foft parts. Vol. XIX. No. 1193. 135 The patient in general is not aware of this tendernefs till it is pointed out by the phyfician. There is often, we have feen, a degree of fullnefs in the right hypochon- drium at earlier periods ; but it is then more tranfitory, being generally relieved and fometimes removed by the effeCls of cathartics, and, not unfrequently, fpontaneoufly difappearing and returning again. The tendernefs above mentioned never exifts long and to any confiderable de¬ gree without the pulfe becoming hard, and it often at the fame time becomes rather more frequent than in health. Sometimes the hardnefs of the pulfe is fo well marked that it is eafily diftinguilhed, but more frequently tire hardnefs is only to be diftinClly perceived by examining the pulfe with the utmoft care. See our remarks on the manner of diltinguilhing the hardnefs of the pulfe, in the prefent article, p. 9/p. The tendernefs of the epigaftrium, after it has lafted for fome time, generally begins to be attended with fome degree of fulnefs in the part, and to extend downwards along the edge of the cartilages, till at length there is a degree of fulnefs, and fometimes ten¬ dernefs, throughout the right hypochondrium, which feels firmer than the left ; but the tendernefs is feldom fo great as in the part of the epigaftrium above deferibed. Sometimes the preflure, both there and in the hypochon¬ drium, rather produces a fenfe of oppreflion, affeding the breathing, than pain. Sometimes, particularly in the epigaftrium, it occafions pain palling through the body towards the back, fometimes quite to the back, at other times a fixed pain or fenfe of oppreflion under the fternum, and, in fome cafes, a pain extending to the left fide. The tendernefs of the epigaftrium, as well as the hard¬ nefs of the pulfe, are perceived molt clearly when the patient has been taking exercife; mufcular aCtion, as might be expeCted, increafing the phenomena of inflam¬ mation. We mull not forget to remark, with refped to exercife, that its performance is often attended with much uneafinefs, all motion except of thepaflive kind produc¬ ing an infupportable degree of languor. This obtains chiefly, however, in the more fevere forms of the affec¬ tion, the flighter ones being ufually free from it. Thefe fymptoms are generally accompanied with others indicating fome degree of feverilhnefs. The chillinefs of which the patient has long complained is now fometimes, and independently of any change of temperature in the furrounding medium, interrupted by languid and op- preflive fits of heat; and the hands and feet, inftead of being uniformly cold, as in the earlier ftages, often burn, particularly during the firft part of the night, while at other times they are more obftinately cold. The thirftalfo often increafes ; and fometimes there is a tendency to partial fweats in the morning, efpecially if the patient lie longer than ufual ; and thefe fymptoms are generally attended with an increafe in fome of thofe of the firft ftage. The inflammatory ftate of the ftomach proceeding un- fubdued, organic changes are foon induced, and thick¬ ening of its coats ; ulcers, feirrhus, and a variety of ftrudural derangements, occur. More frequently, how¬ ever, the inflamed ftate of the ftomach and bowels fub- fides, while the organs to which its difturbance has been propagated undergoes the ftrudural diforganization. The liver, lungs, fpleen, pancreas, lower bowels, mefen- teric glands, heart, and brain, are faid to be moft obnox¬ ious to this occurrence ; but it cannot be queftioned that every part of the body is liable to . the lame changes, and from the fame caufes. Sometimes one of thefe parts is aft'eded, fometimes many; and it is to be remarked, that, in eonfonance with the known laws of pathology, when difeafe eftablilhes itfelf firmly in a fecond part, the firft is relieved from it. Indeed there feems this further difference between the mere nervous excitement which fupervenes to the firft ftage of Dyfpepfia and the inflam¬ matory affedions we are now treating of, that, while tire N n former 136 PATHOLOGY. former tend to keep up and increafe the original difeafe, thefe (the latter) aft on that which excites it in the fame manner as a counter-irritant is known to do, though tinqueftionably in a much more effeftual manner. Thus, it is not uncommon in indigeltion for the liver to fuller in fuch a manner, that it (hall become enlarged and ten- deron preffure; and, when ahe difeafe' is deftroying the texture of the lungs, having fpread from the liver to them, for the former to recover, or nearly recover, its healthy ftate. And thus an extenfive external difeafe, occurring in fuch cafes, will often fave the vital organ, even after the difeafe has made confiderable progrefs in it. It is obvious, then, from the foregoing remarks, that the treatment of all difeafes remotely traceable to indi¬ geftion are not to be difcuffed in this place ; nor are the diforganizations of the ftomach to be treated of here; as each of thefe form diftinft fpecies, and require feparate confideration. It only remains therefore to trace the dif- ordered Hates of the fanguineous and fecretory funftions arifing in the fecond ftage of Dyfpepfia; and to notice the general indications for the relief of the local, and the particular indications for the cure of the general, difeafe. For the reafons Hated in p. 108, we lhall forbear to mention all the complaints traceable to the confirmed ftage of indigeftion. Indeed it would feem from what we have there remarked, that, as thefe propagated complaints are literally the complaints of the fanguineous and nervous ftrufture of the parts affefted, they are diftinft and idio¬ pathic; that ■they are inflammations, however induced, and therefore to be met with the ufual remedies for that aftion. But praftical conflderations (which fhould fuper- fede all other) induce us to notice certain cafes in which experience has ftiown that the moft marked and ferious forms of chronic inflammation, and of difeafed fecretion, have been cured by the medicinal treatment of dyfpepfia ; and we think that, when the laws of fympathy are better known, this divifion will appear no lefs philofophical than praftical. We have before adverted to the impoflibility of drawing an accurate diftinftion between inflammations which, though produced by nervous irritations, are ren¬ dered permanent by their own difeafed tendencies, and thofe which are merely fympathetic. And, in the cafes we are about to confider, probably a ftill greater difficulty of diagnofis exifts. The difficulty in thefe cafes is to efta- blifti how far, when the original caufe of dyfpeptic dif¬ eafe is removed, the parts will return to their natural .ftate. Reafoning a priori, we (hould conclude, that the ope¬ ration of this caufe could not extend beyond inflamma¬ tion and altered fecretion ; but experience has clearly fliown, that, nervous irritation being removed, difor- ganized parts undergo reparative proceffes, and in an aftoniiliing manner may refume their natural ftrufture. In the nervous fyftem we remark, that the head is in¬ fluenced in this difeafe in a manner decidedly inflamma¬ tory. This inflamed ftate of the cerebrum, in the fecond ftage of indigeftion, is well ffiown by head-ache, by in- creafed hardnefs and fulnefs of pulfe, and by the in- creafed pain which the recumbent pofture produces. As it advances, various forms of mental difturbance become rnanifeft. In this form of difeafe we mull be efpecially careful not to let our notions of the dyfpeptic origin of the difeafe weaken the vigour of our pradlice ; for local and (when the date of the circulating powers demand it) ievere general depletion are neceffary here, as in idiopathic difeafes; and indeed, as this is the part where the moft intimate connexion between the fanguineous and nervous fyftems takes place, we Ihculd naturally ex- peft to meet with this faft. It fometimes happens, in this fecond ftage, that the head-ache aflumes a chronic form, continuing for weeks, or even months, without being very fevere. Both local and general blood-letting then very frequently fail to give permanent relief. The bell means are thofe which iupport an habitually-free aftion of the bowels and Ikin, (and moft efFeftually correft the difeafe of the digeilive organs,) and permanent drains from ther neighbourhood of the head. There are two occurrences which ought ever to be pre- fent to the mind of the praftitioner : the firft is the ten¬ dency to the tranfition of nervous into idiopathic inflam¬ mation, which is particularly obferved with regard to the head; the fecond, the poffibility of the co-exiftence of the two ftates. The tranfition of the affeftion of the head in Dyfpepfia into an idiopathic inflammation, or the co-exiftence of the latter affeftion with the former, is to be apprehended on the occurrence of any of the following lymptoms in a ferious degree and continued form : A fenfe of flu'hing or fulnefs about the head ; acute pain of the head ; un- ufual heavinefs, dull head-ach, or vertigo ; drowfinefs, ftupor, difturbed fleep, delirium, incubus, ftertor; for- getfulnefs, timidity, confufion of mind; change of affec¬ tions ; tendency to laughter, and tears ; affeftion of the fenfes, as temporary lofs of fight, flalhes of light, double vifion, finging or loud noifes in the ears, intolerance of light, or found ; tendern^fs of the fealp. Many of thefe fymptoms, however, occur in the firft ftage. It is only when they exift in an eminent degree that they denote danger. But it is bell to take an early alarm. The danger of compreffion of the brain is unequivocal on the occurrence of an untifual diftortion, or an unmeaning expreffion, of the countenance ; of a deleft in articula¬ tion ; of a temporary numbnefs or torpor, or of tranfient and partial weaknefs of any of the limbs; efpecially if one fide of the body alone be affefted. The occurrence of ftupor, convulfion, paralyfis, or relaxation of thefphinc- ters, leaves little to doubt refpefting the exiltence of this fatal occurrence. In fome cafes, the erethi final ftate of the brain before noticed puts on a more marked and formidable appear¬ ance ; and it is not very unufual, when this difeafe has continued fome time, to fee the patient, after more fe¬ vere attacks than ufual, and fometimes without this warning, fuddenly fall down, and in a few hours, and in fome cafes almoft immediately, expire. In fuch cafes the aids of medicine are vain. The powers of the con- ftitution are not oppreffed by difeafe, but worn out by its continuance. This is what, in contradiftinftion to apoplexy arifing chiefly from the ftate of the veflels, is properly termed nervous apoplexy, the moft fatal of all its forms ; and. it has been remarked, that in fome cafes no morbid appearance prefents itfelf on diffeftion : the fatal derangement is in the nervous fyftem alone, whole ftruc- ture is too minute for our obfervation. If the ufual plan of bleeding in cafes of fudden infenlibiiity be here re- forted to, the difeafe is only the more fuddenly fatal. The ftate of the brain in fuch cafes refembles that which furgeons call eoncvjjion. Its mechanifm is deranged. The difference is, that in the one this mechanifm is de¬ ranged by a fudden and violent caufe, applied while the powers of the fyftem are entire ; and which, confequent- ly, if the little ftrength that remains be carefully huf- banded, may often repair the injury : the other is the effeft of a fucceffion of flight caufes gradually changing the mechanifm of the brain, and at the fame time ex- haufting the powers of every other part, fo that the con- ftitution poffeffes no means of repairing the injury. The pure nervous apoplexy, however, as here deferibed, is an extremely rare difeafe ; becaufe it very feldom happens that the caufes continue long enough fo to derange the finer mechanifm of the brain as to produce lofs of func¬ tion, without influencing the ftate of the circulation in it in fuch a manneras to produce a fatal effeft in this way. It more often happens, that difeafe of veflels caufing apoplexy is produced ; and it is worthy of remark, that in this ftate a pallid countenance is ufually met with. This circumftance occurs occafionally in all the forms of apoplexy ; but we think it is more particularly noticed in this than in any other. Dr. Philip fays, “ I have repeat- PATHOLOGY. 187 edlyfeenj in an exhaufted conftitution, the face become fuddenly pale, and all power loft, the patient falling down infenfible, and the countenance continuing to in- creafe in palenefs till it a /Turned a cadaverous hue ; and yet this patient has been immediately reftored to the ufe of his faculties, the palenefs of his countenance at the fame time abating, by the lofs of blood; and there is every reafon to believe would have died without it. For it is evident that the apoplexy we are coniidering is of a different nature from detention of the veflels of the en¬ cephalon arifing from general fulnefs; and therefore lofs of blood from the head, and that only to fuch an extent as relieves the fymptoms, is alone proper; the incautious ufe of general blood-letting in fuch a cafe being alfo fol¬ lowed by a degree of debility which further difpofes to returns of the attack, as well as to other difeafes.” The effeft of the gaftric irritation in debilitating the veflels of the head, might be illuftrated by many faffs : it is enough to mention the flufhing of the face which occurs to dyfpeptics after dinner. Of the nature of epilepfy fo little is known, that any attempt to trace its connexion with indigeftion nuift be futile ; nor indeed does there appear any real difference in the difeafe, let it arife from what caufe it may. The moft chronic and inveterate form in which the brain is affeffed through the gaftric media, is that of hy- pochondriafis. We fhall referve our fpeculations as to the nature of this complaint till we come to the clafs Neurotica, in which we fhall take up the fubjeft of ner¬ vous irritations arifing from indigeftion on a more ex¬ tended fcale. It will be fufficient at prefent to ftate, that in confidering the mutual aftion of one part of the fyftem on another, the ftate of the mind deferves particular at¬ tention in indigeftion. The difeafe itfelf w'e have feen feldom fails to render it anxious, irritable, and apprehen- five ; and this ftate of mind, which we have found ranked among its caufes, cannot fail to influence its fymptoms. The affections of the mufcular fyftem which fuperVene on this ftage of indigeftion, are of a gouty or a rheuma¬ tic nature ; and, like other inflammatory affeCions, they prefent lefs indication of plethora when dependent on gaftric difturbance, than when they arife from other caufes. It muft not be forgotten, that an ill ftate of the abdo¬ minal vifcera is always connected with chronic rheuma- tifm ; a circumftance which induces us to defer tracing theconnexion, or noticing the peculiarities, of that dyf- peptic variety in this place. We fhall remark, how'ever, that, where a tendency to gout exifts, difeafe may be induced by any caufe that produces, and for a certain time keeps up, indigeftion. In fome the difpofiticn to gout is fo great, that it appears without being preceded by fymptoms of derangement in the firft paflages ; but in the majority of cafes it is preceded by thefe fymptoms, and the tendency to them feems to conftitute a con/idera- ble part of the hereditary difpofition' to gout. The regular forms of this difeafe, not affecting a vital part, tend lefs to derange the fyftem in general, and give more relief to the primary difeafe, than moft of the other fymptomatic affections which have been enumerated, the patient often remaining well for fome time after; and, the more cautious be is in preferving the vigour of the digeftive organs, the longer interval he enjoys. Hence appears the danger which attends interrupting the regu¬ lar fits of gout : the fympathetic difeafe, being prevented from taking the courfe which the difpofition to affeclion of the extremities gives it, feizes on the part, generally an’ internal one, which nex.t to thefe is moft liable to difeafe; and, on the other hand, if any thing fo aftefts any of the vital parts during a fit of gout as to render it confiderably the weakeft part, the fympathetic difeafe fometimes leaves the joints and feizes on the internal part, producing what is called retrocedent gout. It is evident that the rifle of both thefe accidents will be greateft, where the powers of the fyftem are moft im¬ paired. The mufcular fyftem is likewife afFefted in fome cafes by a permanent and gradual debility, by tremor, and by lofs of fubftance. The latter circumftance is much dwelt upon by Dr. Hall, who weighed feveral of his pa¬ tients, with a view to more correct information on the fubjeft. It will be found, however, that fome dyfpeptic patients retain their embonpoint, notwithftanding much functional difturbance. The patients/of indigeftion are ufually aflefled with great tremor, obferved fometimes in a quivering of the lip, or dimpling of the chin, but more ufually, on hold¬ ing out the hand, or in carrying a cup of tea, for iriftan.ee, to the mouth, on attempting to Hand ereft or walk, or on being fatigued or hurried. The tremor, in fome pro- trafted cafes, has formed the moft remarkable feature of the affeCtion ; in others, it has been much lefs obferved, but it is rarely, if ever, entirely abfent. The debility which now comes on is, as we have be¬ fore obferved, of a different nature from that merely- nerv.ous inaCtion which happens in the early ltages of the complaint. The latter is the mere want of nervous fti- mulation, while the former feems to be a change in the contractile power of the mufcular fibre, probably derived from the morbid ftate of the blood, and indicating much danger. The heart is often affeCted in the fecond ftage of indi¬ geftion, in various and fevere modes. The palpitation which in the firft ftage was merely nervous, in fome in- ftances now becomes fo obftinate, as to affume the form of angina peCtoris, carditis, See. and, being accompanied with an increafed hardnefs of pulfe, can only be relieved by lofs of blood. Dr. Philip has noticed a connexion between rheurna- tifm and this fort of carditis. He fays, “It is a common obfervation, that carditis is apt to fuperverie after re¬ peated attacks of rheumatic pains of the limbs. I believe from many cafes which have fallen under my obfervation, that it will generally be found, in fuch inftances,.that the rheumatic pains had been combined with, and in a greater or lefs degree dependent on, diforder of the di¬ geftive organs.” The pain of the limbs arifing from this caufe, often aflume the form of idiopathic rheumatifm, and become very obftinate, if the caufe which fupports them be overlooked; which is the more likely to happen, as cold is very often the immediate exciting caufe. Dr. Philip has feen fevere pains of the limbs, which had long relilted the means ufually fuccefsful in rheumatic cafes, wholly removed by combining with thefe means the treat¬ ment adapted to the fecond ftage of indigeftion ; and it is well known to furgeons, that the fwelling of the knee- joint which fometimes accompanies the rheumatic con- ftitution, is only cured by the fame indication. On turning our attention to the other vifcera, we fee the fpafmodic contractions of the bowels, and their oc- cafional difturbance of function, developed in the early periods of indigeftion, now terminating in inflammation, ftri/ture, adhelions, piles, &c. The figmoid flexure of the colon appears to be a part very liable to be aftedled with inflammation, probably from the contents lodging there longer than in other parts of the large inteftines. It is not uncommon in protracted cafes, to find a confiderable degree of tendernefs in the feat of this part, which is fometimes at length affected with ulceration. It is alfo common to find tendernefs on preflure in the feat of the ccecum. The liver, too, aftumes an inflammatory appearance. We often find, when the patient takes cold, orisexpoled to other caufes of inflammation, or the dylpeplia is ag¬ gravated, the greater part of the right hypochondrium becomes full and tender on preflure, with a fenfe of op- preflion and an increafed hardnefs of pulfe, often accom¬ panied with fome degree of dylpncea, and a dry teafing cough. He fometimes complains of pain in the right, not unfrequently in the left, hypochondrium, or in the pit of the ltoinach, or in the right or left fiioulder; and experiences 4 138 PATHOLOGY. experiences Tome uneafinefs in lying on either fide, par¬ ticularly on the left, the common derangement of the biliary fecretion being rendered more marked with thefe fymptoms. The hepatic inflammation thus induced is feldom, however, of that adtive kind which requires ge¬ neral blood-letting; a fortunate circumftance, as patients of this defcription rarely bear lofs of blood well. Thefe attacks generally partake of the chronic nature of the habitual difeafe, and for the mod part yields to local blood-letting and blifters, with the aid of a mild diet and faline and aperient medicines. The pain is often felt in the left fide, while the ten- dernefs on p re flu re is wholly confined to the right; but, after the affedlion of the right fide is relieved by evacua¬ tions from the tender part, it is not uncommon for the left fide to become both full and tender, the inflammatory affedlion appearing to attack the fpleen as foon as the liver is relieved from it ; and it will fometimes, on the fulnefs and tendernefs of the left fide being relieved by the fame means, return to the liver. This alternation often happens more than once before the difeafe fubfides. Sometimes, though much more rarely, the fulnefs and tendernefs appear in the left fide alone. The pain is then more confined to the feat of the tendernefs. Whenever the liver becomes thus implicated in the in¬ flamed ftate of the ftomach, it leads to a train of fymp¬ toms arifing out of hepatic derangement, which demand ferious attention. It is not the leaft of thefe, that the re-adling difeafe aggravates the gaftric difturbance, a cir¬ cumftance which very often perplexes us in the diagnofis. But we mull poftpone further refearches till the fubjedt of difeafed liver comes before us. The connexion of urinary gravel with dyfpepfia is worthy of particular notice. We are indebted to Dr. Philip for an ingenious fpeculation on this fubjedl. He tiiinks that it is not by fympathy alone that indigeftion excites urinary gravel. He (hows that in moll cafes of dyfpepfia there is a confiderable produdlion of acid in the fir ft paflages; and this acid, as appears from his experi¬ ments, enters the mafs of blood, and is thrown out of the fyftem by the Ikin and kidneys. As all other acids occa- fion a precipitation of lithic acid from the urine when the adlion of the Ikin is impaired, the one we are fpeak- ingof often paffes in fuch quantity by the kidneys as to caufe a depolition of lithic acid before the urine leaves thefe organs, which there (probably in confequence of being agglutinated by a fecretion which its ftimulation excites on the internal fur face of the kidney) frequently concretes into fmall maffes occafioning fits of gravel. A precipitation of lithic acid is often obferved in the urine of dyfpeptic patients, after it has Hood for fome time ; and that the gravel which afflidls them is only a greater degree of this fymptom, appears from the obferva- tions of the bed writers on calculous difeafes, who con- fider the calculi formed in the kidney to be almoft always concretions of lithic acid. Dr. Philip feems to confider, that, in difputing that the kidneys are affedled by fympathy with the ftomach, lie is borne out by the fadl, that while, as we have feen, the other inteftinal organs are peculiarly liable to a flume the inflammatory ftate of the fecond ftage of indigeftion, the kidneys feldom fhow any tendency of this kind. This affertion feems, however, by no means confonant with experience ; but Dr. Philip obviates the difficulty by faying, that, “ it is not uncommon, in indigeftion, for the acrid ftate of the urine, arifing from the f'uperabun- dance of acid and its other faline contents, occafioned by the greater generation of acid in the alimentary canal, and the inadlivity of the fkin, fo to irritate the urinary paflages as to occafion frequent midlurition, and a fenfe of burning, and other painful fenfations in thefe paflages, even when no depofition of lithic acid takes place in them.” Without attempting to invalidate this theory, or even to prove diredt fympathy between the ftomach and kidneys, we cannot help thinking, that an indiredl fym¬ pathy between the ftomach and kidneys, through the me¬ dium of the fkin, would account for the circumftance we are confidering in a manner more confonant with general principles, and equally capable of demonftration. In profecuting further the groups of fymptoms which a rife from dyfpepfia, cachedic diforders will hold a promi¬ nent rank. The marafmus both of infants and adults is. often diredlly traceable to the undigefted ftate of the pa- bula vitae, even where no affedlion of the abforbents of the mefentery exifts ; fo that tabes, atrophia, &c. will (as we (hall endeavour to fhow when thefe are on the tapis) often gain relief from the treatment of dyfpepfia. There is, however, one fpecies of cachedlic diforder which we mu ft notice here for want of a more, fit place in our nomenclature : vve allude to a ftate which has been de- feribed by Dr. Hall as a variety of ( what he calls) th« Mimofis acuta; and which appears an analogous diftem- per to that noticed by many authors under the terms purpura, Jcorbutus, &c. This affedlion is indicated by all thofe fymptoms which we fhould naturally infer from a morbid condition of the circulating fluids; for inflance, by deficient adtion of the mufcular fibres, manifefted in its larger ftrudlures ; by languor, indolence, and debility ; and, in its Irnaller ones, by various topical congeftions, and by haemorrhage ; and thefe latter are peculiarly re¬ markable on the (kin and the nervous expanfions. The fkin, being prefled or otherwife injured, betrays extra¬ ordinary marks of want of tone, or of the refinance to, and recovery from, unnatural agents, which healthy ftrudlures fo remarkably difplay ; and it is fometimes af¬ fedled with a continued though variable ftate of fallow- nefs, of yellownefs, or idlerode hue ; of darknefs, or of a wan, fqualid, or fordid, palenefs of complexion ; or a ring of darknefs furrounding the eyes, and extending a little perhaps towards the temples and cheeks, and fo mu¬ tinies encircling the mouth ; and the gums, throat, &c. are peculiarly liable to fall into ulcerations, haemorrha¬ ges, &c. Pains in the bones are often felt. We feledl a cafe from Dr. Hall, which, though it does not exemplify this complaint in its word form, yet is worthy of per¬ manent record, becaufe it ferves to trace the difeafe very conclufively to a dyfpeptic origin. “ E. M. aged"35, a framework-knitter, tall, flout, and healthy, was employed, in 1815, in the moll a drive and laborious manner, in hay-making; he was expofed to great heat, underwent much fatigue, perfpired profufely, and drank copioufly of beer and ale. He became affedled with weaknefs, liltleffnefs, lofs of flelh, nodturnal perfpi- ration, head-ache and vertigo, lofs of apetite, and idlertis, with pale-coloured (tools and deep-coloured urine. He recovered from thefe complaints; but in the year 1816 had the misfortune to break his leg. In confequence of this accident and the fubfequent confinement, he became and remained indifpofed ; he gradually loft flefh, and from i4ftone, weighed between 12 and 13 only; and ex¬ perienced, on taking cold, a lofs of apetite and flrength, with an inability to work, not known before. In No¬ vember 1817, he underwent much bodily exertion, and remained expofed to the cold and damp. He took cold, and became affedled with hoarfenefs, fore throat, a net cough, with oedema of the ankles. Thefe fymptoms ceafed, except the oedema, which receded however gra¬ dually ; but he was ftill affedled with the following com¬ plaints, which are copied from his own account of them : Lofs of flefh, and of flrength ; a feeling of internal weak¬ nefs ; feverifhnefs, a parched and dry Hate of the throat, and fometimes of the tongue; fenfibility to cold, chilli- nefs, tendency to perfpiration, efpecially in the night; head-ache ; fleepineis ; dulnefs of fpirits ; nervoufnefs j fluttering at the heart and about the ftomach; cough-; dyfpncea ; a clammy tongue and mouth, and foetid breath ; lofs of appetite, fenfe of load at the ftomach, occafional rejedlion of food, conflipation, and pain in the chondiliac regions. This patient became much better from the ufe of gentle purgatives of calomel, rhubarb, and Epfom 130 PATHOLOGY. Epfomfalt. ButinAuguft 1818, he became affeCled with fevere and continued diarrhoea, with a lofs of flefh from 1 1 ft. alb. to ioft. 6lb. and lofs of ftrength, and aching and wearinefs, and pain in the fhoulders, fides, and legs. He again recovered under fimilar remedies ; but, in Novem¬ ber 1818, was taken with feverifhnefs, attended with a parched tongue and mouth, fome delirium in the night, and further lofs of flefh and of ftrength 5 and, at the fame time, there occurred an extenfive ulceration of the back part of the pharynx, and a confiderable difcharge of bloody mucus from the noftrils. He was reduced from 1 oft. plb. to 9ft. alb. This ftate continued, and ic¬ terus again occurred, with the ufual appearance of the tunica albuginea, ikin, urine, and ftools. Soon after this time I made the following lift of appearances and affec¬ tions in this poor fufferer’s complaint : 1. Swarthinefs of complexion; 2. feverilhnefs, with parched throat and mouth, and heat of the forehead and legs ; 3. tendency to perfpiration 5 4. quivering of the chin and lips in fpeaking, fimilar to that obferved before fhedding tears ; 5. tremor ; 6. fluttering; 7. lofs of flefh ; 8. difcharge of bloody mucus from the noftrils, with ulceration ; 9. ul¬ ceration of the throat; 10. ifterus; 11. difcharge of much blood and mucus from the bowels, preceded and attended by pain of the abdomen, with tenefmus and forcing; 12. the ftools, otherwife, light coloured; 13. fome anafarca; 14. boils ; 15. painful ulcers on the legs.” ConneCfed with the fame morbid ftate of the body ge¬ nerally, we have to obferve thofe anomalous and diftrefling cafes which we denominate fiphilodes. But more of this under that term. Another cacheCtic difeafe muft be here treated of. We have before fhown, that nervous excitement may produce the phenomena of hyjleriu, whether it be derived from the ftomach or uterus; and, in confidering chlorofis, there feetns every reafon for fuppofing that a fimilar circum- ftance occurs ; viz. that, while chlorofis is a difeafe gene¬ rally caufed by the want of due catamenial difcharges, the want of proper digeftion, whether from deficient fen- fation or morbid abforption, may fimulate, if not lite¬ rally produce, the fame complaint. A fadt refting on good authority fpares us the trouble of reafotiing in proof of this affertion : it is, that the male fex are by no means exempt from attacks of this kind, efipecially the young and fedentary. Chlorofis is evidently a bad term for this aft'edtion ; nor do we like Dr. Hall’s term, Mimofis deco¬ lor, becaufe the expreflion of mimicking difeafe is not quite applicable to it. We however borrow from that author the defcription of it, and therefore admit for the prefent his nomen. Th e incipient Jluge of the Mimofis decolor is denoted by palenefs of the complexion, an exanguious ftate of the prolabia, and a flight appearance of tumidity of the coun¬ tenance, and puffinefs of the eye lids, efpecially the upper one. There is fometimes a tinge of green, yellow, or lead-colour, and frequently darknefs of the eye-lids. There is great palenefs of the general furface, hands, fingers, and nails; an opaque, white, tumid, and flabby, ftate of the flcin ; a tendency to oedema of the calves and ankles ; and a certain lofs of flefh. The tongue is white, and loaded ; it is fwollen, marked by preffure againft the teeth, or varioufly formed into creafes or folds ; its papil¬ lae are very numerous, and much enlarged. The gums and the infide of the cheeks become tumid ; and the lat¬ ter, as well as the former, are fometimes impreffed by the teeth. The breath is tainted. The patient is generally languid, liftlefs, indifpofed for exertion, eafily overcome by exercife, nervous and low-fpirited, drowfy, dizzy, fainty, or breathlefs. There is generally fevere head¬ ache or vertigo ; the memory and power of attention are apt to be impaired ; and there is fometimes. lieavinefs for fleep. There is alfo, in different inftances, pain of one or both fides about the falfe ribs, or in the hypochondriac or chondiliac regions. Sometimes there is cough, diffi- Vol. XIX. No. 1293. culty in breathing, palpitation or irregular action of the heart, or imperfeCt fyncope, and almoft univerfally a fenfe of fluttering about the prsecordia. The appetite is gene¬ rally impaired. There is frequently a morbid appetite for acids, or for magnefia. The bowels are conftipated, a ftate which fometimes leads to diarrhoea ; the fasces are dark-coloured, fcetid, and fcanty. The urine is fre¬ quently loaded. The catamenia become irregular, are preceded and attended by much pain of the back and re¬ gion of the uterus, and fometimes, but not always, be¬ come flowly defective in quantity, and pale in colour. In the confirmed ft age of this affeCtion, the ftate of the complexion and general furface is ftill more marked. The countenance is more pallid ; the prolabia and the gums exanguious; or the prolabia, efpecially the upper one, have a flight lilac hue; and the integuments are tumid. The flcin is fmooth, but becomes preternaturally dry; the integuments are puffy, opaque, and pale, or yellowifh ; and there is a tendency to cedema of the feet. The tongue becomes clean and fmooth ; but it is pale, with a flight but peculiar appearance of tranfparency, and of a pale lilac hue; and it remains a little fwollen and in¬ dented. The patient is now affeCied with languor, laffi- tude, and even ferious weaknefs, being at once reluCiant and unable to undergo fatigue. There are often attacks of fevere pain of the head, or of equally fevere pain of the fide ; and repeated bleeding, leeches, and blifters, are ufually employed, affording a temporary refpite from thefe complaints. There are alfo, fometimes, fits of dyfp- ncea, of palpitation of the heart, or of fainting, with beating of the carotids. The pulfe is rather frequent, often about 100, and eafily accelerated and rendered irre¬ gular by mental emotion. The appetite is fometimes impaired, occafionally greater than natural, and very fre¬ quently depraved, inducing a longing or conftant defire for fome indigeftible fubftance, as acids or pickles, mag¬ nefia, chalk, cinders, fand, coffee-grounds, tea-leaves, flour, grits, wheat, &c. which the patient likes to have conftantly in her mouth, or to which recourfe is had when Ihe fuffers from agitation of mind, (like the dirt- eating negroes, p. 122, 3.) The bowels are flow and conftipated, a ftate which fometimes alternates with diarrhoea, and in¬ duces melrena ; the ftools are dark, foetid, and fcanty. The catamenia are attended with pain, and become paler, and lefs in quantity, often ceafe, and often yield to a ftate of leucorrhoea which is more or lefs conftant. In the inveterate fiage, all the fymptoms affume an ag¬ gravated character. There is a very flow, but progreffive, lofs of flefh. The languor becomes a ftate of permanent debility. The cedema increafes, and takes on the aggra¬ vated form of anafarca. The pulfe becomes frequent. There are lefs of the appearances of mere diforder, and more of the charaCterof difeafe ; i. e. thofe local affections, which exifted in a lefs continued manner before, now be¬ came either permanent, or are induced by the ftighteft caufes ; and the patient can fcarcely bear the moft ordi¬ nary occurrences of domeftic life, and perhaps remains always in bed. Sometimes there is an almoft permanent pain of the head, perhaps with intolerance of light or of noife; fometimes pain of the cheft, with tendernefs, diffi¬ culty in breathing, and cough. Frequently there are pain and tendernefs of the abdomen, with ficknefs and conftipation, or with diarrhoea. Different fymptoms reign in different inftances ; as fome hyfteric or fpafmodic affeCtion ; a ftate of locked jaw, clofed hand, contracted foot, or twifted limbs; palpitation of the heart; hurried or fufpended refpiration ; long fits of coughing, hiccough, retention of urine. It is worthy of notice, that this chlorotic ftate and the cacheCtic difeafes noticed before are often alter¬ nate, or run into one another. An important connexion feems to exift between the pathology of the ftomach and the mucous membrane of the lungs. In the firft ftage of indigeftion, an irregular and fpafmodic cough is often produced by nervous irrita- O tion, 140 PATHOLOGY. tion, as we have before feen; and, when the inflammatory ftate has come on, an inflammation of the mucous mem¬ brane of the bronchia is no uncommon occurrence. In cafes where predifpofition to difeafe exifts, idiopathic dif¬ eafe. enfues ; but more commonly a dependance on the original diforder is ftill remarked in ftru&ures fecondarily affe&ed. Affe£tions of more feverity, and which perhaps have their feat more immediately in the parenchyma of the lungs, are thofe which dyfpepfia gives rife to when implicated with difordered liver. The latter vifcus in¬ deed holds a very important relation with the pulmonary organs, whether in health or in difeafe. When we come to treat ofinflammation of the mucous membrane of the bronchiae, we Ihall fpeak more fully of the fympathetic a£tion of the mucous expanfion. Suffice it to fay at pre- fent, that communicated difeafe is frequently obfervable between the ffomach and lungs. Dr. Haftings, in his Treatife on Bronchitis, has very accurately delcribed the difeafe in queftion. It is diftinguilhed by the ufual figns of bronchitis (which fee) ; fuch as, tightnefs of the cheft, cough, copious expeftoration, &c. and the further pre¬ fence of various dyfpeptic fymptoms, as well as indireftly by the effect of remedies ufed in indigeftion. But often more fevere difturbances arife ; and the violence of the fymptoms approaches clofely to the charafteriftics of ftrudtural alteration. Indeed every one fees cafes appa¬ rently of phthifis which yield to the treatment for indi¬ geftion. For our own part, we wilh to confine the word phthifis to the apoftematous or tubercular kinds. Now, with regard to the former, we conceive nc one will aflert that it is curable by dyfpeptic treatment ; and, with re- fpe£t to the latter, fcarcely a bolder prognofis will be given. It muft be conceded, however, that the latter form of difeafes may be thus cured. Mr. Abernethy has de- monftrated to a mathematical certainty, that the repara¬ tive procefles are beneficially influenced in thehigheft de¬ gree by the treatment in queftion ; and we have only to extend this eftablifhed propofition from the vifible exter¬ nal parts to the internal furfaces ; yet, in fo doing, we muft confider, that both the perpetual motion and the aerial ftimulation of the pulmonary organs, render repa¬ ration of ftrufture a moll difficult talk in them. More¬ over it is acknowledged that we have no pathognomonic lign of phthifis; that not even the vomiting of pus can render the exiftence of apoftema unequivocal, fince pus may be fecreted from the mucous membrane in certain ftates of inflammation ; and therefore we Ihall conclude, that ftomachic medicines can be ufed as direct agents only where neither apoftema nor tubercle exifts. We muft be careful, however, where ae fix the bounds between fym¬ pathetic and real difeafe. In the 43d, 44th, and 45th, ieftions of Morgagni’s 21ft Epiftle, we find the difeafe which he calls the pleuritis verminoja treated of at fome length. The author mentions one cafe, in which all the fymptoms of pleurify were well marked, that terminated favourably by bloody vomiting which brought up a worm; and he refers to a paper of Pedratto on the pleuritis vermi- nofa, where the relief obtained by the expulfion of worms from the ftomach and inteftines is unequivocally proved. In this paper it appears, that all who vomited the worms, or palfed them by the bowels, recovered ; while thofe who retained them died. All the common means of treatment in inflammation of the lungs failed; medicines which deftroyed the worms were alone fuccefsful. While their expulfion immediately removed the difeafe, it is impoffi- ble for us to believe that organic alteration of the lungs had taken place ; yet in thofe in whom the difeafe had been allowed to take its courfe, the fame appearances were found in the thoracic vifeera as in thofe who die of other forms of idiopathic difeafe. Analogous cafes are not unfrequently obferved at the prefent day. In regarding the connexion above mentioned, we often find that the difeafed action of the digeftive apparatus is caufed by the pulmonic irritation, and that the action fo induced keeps up and increafes the latter irritation. Thefe cafes are however rare, when compared with thofe in which dyfpepfia is firft manifefted ; and they are feldom found till difeafe has been of long continuance. It is generally preceded by fymptoms of indigeftion, and par¬ ticularly by thofe which indicate fome diforder in the fe- cretion of bile. Contrary to what is ufual in other fpe- cies of the difeafe, the fpirits from the beginning are generally more or lefs deprefled, and the countenance is fallow. While the firft ftage of indigeftion remains, and ner¬ vous irritation is the only caufe of the cough, the latter is ufually dry, or the patient brings up a little mucus after a fevere and often long-continued fit of coughing, which feems to be rather the eft'edl of the irritation of coughing than any thing which had previoufly exifted in the lungs ; for the cough in this fpecies of confumption, particularly in its early Itages, frequently comes in violent fits, in the intervals of which the patient is often but little troubled with it. Thefe fits are particularly apt to occur after he has eaten, efpecially if he has eaten a great deal, or any thing by which the digeftion is difturbed : and on lying down. As the fecond ftage arifes, bronchitis is the moft ufual form of difeafe. The cough becomes more frequent, re¬ turns lefs decidedly by fits, and is attended with a more copious expectoration. An expectoration at firft limpid or glairy comes on. As the difeafe advances, this increafes, though fometimes for a confiderable time without puruloid characters. By degrees, however, we fee fmall portions of an opake pus¬ like fubftance mixed with the expectorated mucus, and the proportion of it increafes as the difeafe advances. In fome cafes the quantity expectorated is aftonifhing, often much greater, in proportion to the feverity of the other fymptoms, than in idiopathic bronchitis. Blood is not unfrequently mixed with the colourlefs matter, and fometimes pure blood is coughed up in the early ftage of the difeafe. After the pus-like expectora¬ tion commences, if blood has not previoufly appeared, it is much lefs apt to appear than in other forms of the dif¬ eafe. If it appear even in fmall quantity after this ftage commences, Dr. Philip fays that the cafe generally proves fatal. The above-mentioned author is likewife of opi¬ nion that, while the blood is mixed only with a tranfpa- rent fluid, there may be good hopes of recovery; or, if there be no admixture of blood, there may be alfo hopes of recovery, if the difeafe has not lafted long. But, when the expectorated matter affumes a fanious appearance, it feems to indicate much danger. In thefe cafes there is of courfe the dull pain and tendernefs in the epigaftric re¬ gion of the fecond ftage of dyfpepfia ; and in progrefs of time, an irregular heCtic is formed, differing, however, from the true tubercular heCtic ; for, though there is ufually fome evening exacerbation, during which the face is generally flufhed, and though the hands and face are occafionally bedewed with perfpiration in the night ; thefe go off before morning. The emaciation too, though it becomes very perceptible, does not proceed fo rapidly as in tubercular phthifis. The latter circumltance feems to difplay itfelf in the fame proportion as the fever. Anorexia, flatus, tender¬ nefs over the liver, pain in the fhoulder, or other hepatic or dyfpeptic fymptoms, are invariably prefent; and, though they vary at different times, the patient is never free from fome of them. The connexion between them and the pulmonary fymptoms is rendered evident by the latter increafing with the former ; fo that, when the epigaftric region is very full and tender, and the flatulence and acid¬ ity more troublefome than ufual, the cough and dyfpncea are fo alfo; and, on the former fymptoms fubfiding, the latter likewife abate. Even the rifing of wind from the ftomach, often, for the time, removes the tendency to cough. If the progrefs of the diforder be not checked, the fymptoms approach ftill nearer to thofe of tubercular phthifis. PATHOLOGY. phthifis, or in fatt that difeafe is formed. He£Hc fever becomes completely formed, and the patient is wafted with profufe perfpirations, anafarca and other dropfical fymptoms often fupervening. As the pulmonic difeafe becomes more clearly formed, the difeafe of the alimentary canal diminishes, as we have before Ihown it is apt to do when idiopathic difeafe (which operates as a derivative) is fet up ; and this occur¬ rence leads of courfe to a fearful prognofis. The intimate connexion between gaftric and cutaneous difeafes has been clearly pointed out by Mr. Abernethy, and the belt practical phyficians of the day. Indeed the natural fympathy which is perceived between the ftomach and the lkin would lead us to expeft fuch a connexion. It is not ftrikingly evinced, however, in moderate tempe¬ ratures, and while no extraordinary agent' is in aflion ; but, when in a high range of atmofpherical heat, when the veflels of the lkin are excited, and the procefs of per- fpiration is increafed, we clearly obferve this confent be¬ tween the lkin and ftomach, as evinced by want of appe¬ tite ; an effeft which is greatly increafed, if to the exter¬ nal ltimulus of high temperature we add fatiguing ex- ercife, whereby the perfpiration is morbidly excited, and the indireft debility of the fub-cutaneous veflels and ftomach (by fympathy) induced. Hence, after pedeftrian exercife in the forenoon during the heat of fummer, and after the perfpiratory veflels have become relaxed, we find a fenfe of fainting at the ftomach, and anorexia ; while, on the contrary, as the weather becomes cool, and the veflels of the lkin contrafted thereby, we perceive the fym¬ pathy in queftion exerted in the oppofite mode ; for a fti- mulus is quickly communicated to the ftomach and the appetite is keen s and again, when the degree of cold is fo great as to induce permanent debility of the veflels of the furface, and this is not immediately counteracted by exercife or clothing, the ftomach, as well as other organs, inevitably fympathifes, and the important procefs of di- geltion is interrupted. As further inftances of this fympathy, we may adduce the effeCts exhibited on the lkin by a glafs of water or wine taken into the ftomach j the breaking-out of fweat which enfues to fome as foon as acids are applied to the cefophagus ; and, when we add to thefe faCts the nume¬ rous examples which daily occur of furfeits, and the de¬ rangements in the colour, fenfation, and function, of the furface immediately consequent on a debauch, we fhall have no doubt in deciding, that, in nine cafes out of ten, cutaneous foulnefs and gaftric irritation are related to each other as caufe and effeCh Among the numerous painful fenfations and impeded functions which we have had occafion to enumerate as confequences of dyfpepfia, we believe there is not one which, primarily occurring, will not produce, as well as follow, that difeafe. Thefe derangements in the circu¬ lating media, all nervous irritations, all agents fufficiently powerful to control the actions of the living powers, impediment in any part of the refpiratory or aflimilating apparatus or in the functions of the mind, all fortuitous lefions, will, unlefs counter-irritations or predifpofitions to difeafe exift in other parts, produce indigeftion. This eftablifhed, it ferves to fhow the imperious neceffity that there is to ftudy the caufes of dyfpepfia, and to direCf our therapeutical maxims accordingly ; and, in fo doing, what a large fund of observation this enquiry admits of, when we turn back to confider the formidable though in¬ complete lift which we have already detailed. In confidering, therefore, the treatment of dyfpepfia, we fhall revert to what we faid, at p, 128, of its firft caufes. The contemplation of thofe which aCt by influencing the nervous fyftem of the ftomach, is of courfe the molt ex- tenfive. It is by this medium that local injuries and to¬ pical inflammations, intenfe ftudy, See. produce gaftric diforder ; and, when the complaint in queftion is thus traced as a confequence, the treatment is obvious. There are fome nervous imprefiions, however, which, though 141 not themfelves continued, induce a train of morbid ac¬ tions which foon exhibit the form of dyfpepfia. Of thefe imprefiions, the moll frequent is the ftate of the atmofphere. The influence of falubrious air in pro¬ moting healthy digeftion cannot indeed efcape the moft fuperficial obferver. This fluid feems to operate bene¬ ficially in various ways. Thus it may promote digeftion by the excitement to mufcular aftion which its ftimulus produces, by the elevating and pleafurable mental emo¬ tions its purity excites, or its healthful impreffion on the mucous membrane of the lungs may be tranfmitted more direftly to the ftomach. Hence it follows, that, on the other hand, the want of due materials for refpi ration muft be feverely felt in the digeftive function. The at¬ mofphere afts on the lkin only by its temperature; but the frequent variations in this refpeft which our own country is fubjedt to, has been long confidered a fruitful fource of bodily ailments. It does not feem that either the cold or heat of our own climate is particularly inju¬ rious, lince the compenfating powers of the conftitution foon render us equal to either extreme ; but that it is the fuddennefs of the change which is fo obnoxious to our health 5 for, while heat augments the cutaneous capilla¬ ries, both in fize and in frequency of aftion, (an eft’eft which extends to fome extent along the arterious trunks,) its abfence induces a diminution of their parietes, and a more-permanent and lefs-frequent contraction ; and, of courfe, a fudden change from one to the other of their ftates tends to diforder the contradlibility of the atonic velfels, by fympathy of thofe of the lungs and ali¬ mentary canal, and by another modus operandi of the general circulating forces. From thefe premifes the management of the dyfpeptic patient, in regard to air, follows in the moft obvious manner. The viciffitudes of the climate he cannot of courfe control ; but he may avoid the more frequent and feverer changes of temperature to which his own im¬ prudence expofes him. We of courfe allude to the falhionable modes of dreffing, and the habit of being out in the night-air. See. Thefe errors, however, have been feverely inveighed againft by a multitude of writers, and, as might have been expedited, with little good to the community, few members of which have the refolution or the inclination to conquer habitual indulgences. It remains our duty, therefore, to point out the heft prevent- atives of danger during the expofure of invalids to the influence of nocturnal temperature. Thefe methods we have extracted principally from the writings of Dr. James Johnfon. After adverting to the deleterious combination of cold and moifture found in the night- air, this gentleman re¬ marks, that there are five circumftances to be attended to when we are fubjedted to its influence ; viz. 1. The con¬ dition of the body before going out of doors. 2. The de¬ fence of the body’s furface while expofed. 3. The de¬ fence of the lungs. 4. The exercife on the way. 5. The condudV to be obferved on getting home. 1. The condition of the body ought to be as warm as poflible, (hort of perfpiration. Many lives are annually loft by the ill-judged caution of lingering about the halls and doors of the heated apartments till the body is cool, before venturing into the air. In this ftate it is highly fufceptible of the baneful influence of the night. It would be better to iffue forth, even with fome per¬ fpiration on the furface, than wait till the fyftem is chilled. 2. Upon the fecond point we need not enlarge. The frequent fight of thick coats, cloaks, See. clearly evince that our countrymen do not offend much againft this re¬ gulation. 3. The defence of the lungs cannot be too ftrongly en¬ forced. They fliouid be guarded from the direft influ¬ ence of the night-air by fuch mufflings about the face as may detain a portion of the air expired from the lungs each time, and thereby communicate a degree of warmth to PATHOLOGY. 142 to each inhalation of atmofpheric air. A large net, for ex¬ ample, folded loofely round the face, will receive a por¬ tion of caloric, or heat, from the breath, at each expira¬ tion, which portion will be communicated to the current of air rufliing into the lungs at each infpiration; and thus the frigidity of the nofturnal atmofphere will be in fome degree obviated. 4. As we proceed into the night-air while the body is warm, fo we lhould, by a brilk pace, endeavour to keep up that degree of animal heat with which we fet out, and that determination to the furface which is fo effec¬ tual in preventing affeftions of any internal organ. 5. As the fudden tranfition from a heated apartment to a frigid atmofphere muff, in fome degree, produce a determination to the centre, and more or lefs check the perfpiratory procefs, fome warm and moderately-ftimu- lating liquid may be taken before going to bed, in order that the functions of the Ikin and the balance of the cir¬ culation may be reftored ; unlefs, as is often the cafe in nervous fubjefts, fpirituous potations caufe reftlelfnefs and want of fleep. It is of confequence, moreover, that the dyfpeptic pa¬ tient lhould avoid the thick fogs and damp air which fur- round all large towns or manufactories 5 and that he lhould therefore remove from fuch fituations into the open country. Or, in cafe his refidence in foreign regions, whether northern or tropical, is the probable caufe of his indifpofition, a return home is of courfe the obvious remedy. As a further method of obviating atmofpherical im- preffions, the nature of our clothing requires fome at¬ tention. Dyfpeptic patients lhould not only endeavour to wear a lighter and warmer clothing than is ufual, but adopt a more uniform fyftem of attire throughout the year ; in which cafe they will, in a great degree, obviate the keen fufceptibility to aerial impreflions for which they are fo remarkable. They lhould avoid likewife the falhionable habits which exift in regard to frequent changes of drefs. The fair fex in particular, and the lefs robuftof our own, are obferved to wear a warm drefs in the fore part of the day, a period when the fun is mod powerful, and when exercife is more ufed ; while the evening or dinner drefs confifts of garments of the thin- neft texture, when the frame is more exhaufted, and the air damp and cold. No words are required to point out the injury fuch a praftice muff inflift on the patients of indigeffion. We have before adverted to the effeft of ftudious habits on the procefs of digeftion. Perhaps a few words on the management of the mind will not be mifplaced. We do not wilh, far lefs hope, to check the patient and abftrafted exertions of genius; but, if it can be Ihown to the philofopher that knowledge will more kindly open her ftores to him who has not corporeal ail¬ ment to deftroy the balmy refrelhment of fleep, and whofe enthufiafm is not liable to be dulled by baneful hypo- chondriafm, he will perhaps be induced to fpend fome of his exiftence, we truff not unhappily, in the lighter difli- pations of converfation, and in the cheering influence of corporeal movements. It will not be loft time. Health has always been confidered the refult of a general and pervading harmony ; that, while one part or ftrufture afts for the fupport of life, another refts. Even the heart, powerful as it is, refts and afts alternately. All other organs obey the fame law ; they have longer intervals of exertion and relaxation, it is true; but ftill they have them. Shall the brain only receive none ? Without en- lifting ourfelves on the fide of the philofopher who faid the mind always thinks, we may fafely alfert, that, ex¬ cept during fleep, the brain is perpetually occupied in re¬ ceiving impreflions, or in performing its own internal operations. If fleep, then, be the only time it is exempt from this toil, how impaired mull the functions of that cerebral ftrufture be which experiences but imperfeftly and for Ihort periods the influence of “tired Nature’s fweet reftorer !” But it is not only by tending to deftroy fleep that too long application weakens the faculty of thought; the time borrowed from the due exertion of the mufcular fyftem is certainly ill applied. That abforption and circulation are facilitated by mufcular motion will be admitted on all hands : and whence does the brain de¬ rive its fuftenance, but from the circulating powers ? And further, who has not felt how at times his mental energy in a few hours of application rapidly overtakes, nay furprifingly outdoes, the laborious ftudy of days, when he toils “ invita Minerva !” The ftudent, therefore, fhould endeavour, above all others, to exercife in fome degree all his powers, his funftions, and his faculties. His employments naturally tend to make him abftinent; and we are well allured, that, if he does not difdain the ufeful lefl'ons of experience in regard to his bodily infir¬ mities, he will find no reafon to coincide in the melan¬ choly but frequent afl'ertion, that intellectual grandeur and corporeal energies are incompatible ; nor will Ovid’s defcription (pallor in ore fedet macies in corpore toto) be longer applicable to him. To apply the fubjeft of the management of the mind more clofely to indigeftion, our prefent fubjeft. The proper exertion of the mind is perhaps too little attended to by dyfpeptics ; yet it is of much importance ; for men¬ tal anxiety is no unfrequent fource of the complaint in queftion, and is always an aggravation of it. Fortunately many of the exercifes which are good for the body aft favourably on the mind alfo ; as for inftance, the lefs-la- borious employments of horticulture and hufbandry ; the driving of a gig, riding on horfeback, See. Occafional occupations in certain games, in which fome degree of corporeal exercife is combined with the employment of the mental faculties, as billiards and the like, are fervice- able. We lhould principally feleft fuch amufements as at the fame time do not engage the feelings too deeply. The glow which poetry infufes over the foul may be fafely indulged in by the man of bufinefs, or by thofe who follow profeflions in which the reafoning faculties alone are called into play. But fuch indulgence is perhaps unfavourable to the poet himfelf. We may admit for the occafion the fable of old, (fee the article Music, vol. xvi.) and try the delicious influence of fw'eet founds over the morbid feelings of the patients in queftion. Some, on the other hand, require the avocations of bufinefs, which lhould be diverted however of the anxiety ufually attendant. The variety of men’s minds requires however the contem¬ plation of objefts of different kinds, though the grand rule is, in refpeft to the mind as in the body, to exercife without fatiguing it. But we may be fpared entering into any thing more than hints, as the fubjeft requires particular application rather than general rules. The fecond caufe of derangement of the gaftric func¬ tion, viz. by diftention of the mufcular fibre, is next to be confidered. We purpofely omit at prefent the diften¬ tion produced by chemical change arifing from a want of nervous power or of fecretion. It remains, therefore, to confider diftention only as far as regards the too-great quantity, or the gazeous or fwelling quality, of the ali¬ ment received. The mod common caufe of diftention of the ftomach is eating too fall ; for, the appetite only fubfiding in pro¬ portion as the food combines with and neutralizes the gaftric fluid, this praftice inevitably tends to induce per- fons to eat more than is requifite or natural ; and, as the gaftric fluid is but flowly 'fecreted, the major part of the food remains in a place favourable, on account of its tem¬ perature, to chemical change without being fubmitted to the counterafting influence of the gaftric fluid : whereas, when we eat flowly, fo that a proper time is given for the combination to take place, the appetite abates before the ftomach is overcharged : for, while digeftion goes on, and the gaftric fluid is only fupplied in proportion as frelh food comes in contaft with the coats of the ftomach, it combines with the food as it is formed, and never excites the 143 PATHOLOGY. the appetite. The truth of this is evident to every one who has obferved that, if his meal is interrupted for ten or fifteen minutes, although he has not eaten half his ufual quantity, he finds that he is fatisfied. The gaftric fluid which had accumulated has had time to combine with, and be neutralized by, the food he had taken. On the fame account a few mouthfuls taken a little before dinner will often wholly deftroy the appetite, efpecially in deli- cate people, in whom the galtric fluid is fecreted in fin all quantity, or of a lefs aftive quality. Moreover, when we eat too faft, the food is not only received into the ftomach in too great quantity, but is fwallowed without being duly mafticated and mixed with the faliva, and therefore without properly undergoing what may be confidered the fir ft procefs of digeftion. It is thus prefented to the fto¬ mach in a ftate in which the gaftric fluid pervades it, and confequently a fits upon it, with more difficulty. In this way eating too faft is injurious, even when the patient eats but little. For thefe reafons, “ to eat moderately and (lowly,” is often found of greater confequence than any other rule of diet. The dyfpeptic, in eating, (hould care¬ fully attend to the firft feeling of latiety. There is a moment when the reliffi given by the appetite ceafes § a Angle mouthful, taken after this,oppreffes a weak ftomach. If he eats (lowly, and attends carefully to this feeling, he will never overload the ftomach. Another frequent caufe of over-diftention of the fto¬ mach is high-feafoning and great variety of food, or fuch as particularly pleafes the palate, by which we are induced to eat after the appetite is fatisfied ; or, by the ftimulus of the high-feafoning, a greater fupply of gaftric fluid than the food call's for is excited, and thus the appetite pro¬ longed. This feems in particular to be an effeft of wine drank duringdinner; and this praftice, although it occa- fions lefs immediate inconvenience than eating too faft, often, if carried very far, by the preternatural excitement of the ftomach, at length impairs its vigour. It is not uncommon, in the diffeftion of fubjefts who have greatly indulged in the pleafures of the table, to find the ftomach enlarged, and its fibres fenfibly relaxed. The degree of diftention which the ftomach undergoes alfo depends much on the kind of aliment. All food ap¬ pears to fwell more or lefs after it is received into the fto¬ mach 5 fome kinds more than others, and of courfe that which is moft difficult of digeftion, cct. par. fwells molt ; both becaufe it is digefted and removed from the ftomach moft (lowly, and becaufe that which moft refills the aftion of the gaftric fluid is moft apt to run into fermentation. It would take up too much time to mention all the kinds of food which are prone, by their gazeous condi¬ ments, to produce gaftric diftention. Generally fpeaking, vegetables have this effeft in a much greater degree than animal food, and in a crude ftate efpecially. Bread often produces it 5 and it is probably on the fame account that malt-liquors, taken during meals, exert a pernicious in¬ fluence over digeftion. Diftention of the ftomach is alfo produced by too much drink, or, as with refpeft to food, by fwallowing it with too great rapidity. Now, with regard to the third origin of dyfpepfia, dis¬ ordered fecretion, it arifes in moft cafes out of the two former dates; and, the errors or accidents producing them being removed, the effeft generally ceafes. When, however, it becomes eftablilhed, its removal implies a much wider indication. In the firft periods of difeafed fecretion, this fluid is perhaps not much impaired in its digeftive properties, though diminiflied in quantity, and pollefled of fome additional condiments. Emulations of various kinds, pain, &c. now occur, but with little gene¬ ral difturbance, which, as wefaid before, a little attention todietfoon fets to rights. In this llage we agree with Dr. Philip in thinking, that a diet compofed of a mode¬ rate portion of animal food and bread is the bell ; but of courfe this rule will be daily excepted againft on account ot conftitutional peculiarities. Though the coB/fid oration of diet is again before us, af. Vol. XIX. No, 1293. ter the ample notice we have bellowed on this fubjeft, (p. 102-106.) it would be fuperfluous to do more than briefly recapitulate the rules to be adopted. Thefe are only to be underltood, and will always be bed remembered, by a knowledge of the digeftive procefs. The patient of indigeftion will therefore in the firft place attend to the due maftication of his aliment ; to its moderately (low tranfmiffion to the ftomach 5 to its degree of moifture, which regards the two points, that it be fufficiently moilt to allow the pervafion of the gaftric juice without weaken*- ing that fecretion by dilution, and without producing fermentation by its own excefs. He will take efpecial care, when he confiders the nature of the propulfive power of the ftomach, that he offers no impediment to that function by taking violent exercife during digeftion. He will carefully note and partake of thofe fubllances which on their reception into the ftomach produce lead pain or irritation. He will avoid thofe, on the contrary, which produce any ill feeling; namely, for the moft part the tough, oily, oracefcent, particles of food. Nor (hould various kinds of food be taken at once by the dyfpeptic. Few patients will digell well more than one fort of ali¬ ment at a meal. Moreover, the popular notion of taking little and often is to be regarded as a popular error: and when it is confidered, that the maftication and other precedes belong to digeftion, that economy in which nothing is vain, and which are in faft indifpenfably necef- fary, the dyfpeptic (hould not evade the neceflity of fuch precedes by taking aliment reduced to a pultaceous con¬ fidence. We dwell on this point, becaufe it is fo common to hear of nour'Jhing food, an expreffion which, in its common acceptation, is meant to imply the capability of certain fubllances to nourilh our frame rather by its own nature than by that of the digeftive aftion. Thus a va¬ riety of jellies, rich foups, &c. are laviflily bellowed on the emaciated fufferer, and thefe greafy llimulants fail not to deftroy the little remaining function which the ftomach may poffefs. Dr. Philip fays very wifely, when fpeaking on this point, that, “ however impofing the plans of concentrating much nutriment in a fmall com- pafs may at firft view appear, we may be well adured, that in fuch concentration fomething is taken away from what nature deligned for our food, which is ufeful to us.” Thus moft dyfpeptics find, that potatoes, for example, finely maflied, although without any admixture, are more difficult of digeftion than when properly mafticated. To mention a more ftriking faft : it has been fliown by the chemifts, that a very clofe analogy, an apparent identity indeed, exifts between fugar and the chyle which is de¬ rived from vegetables; yet a horfe fed on fugar will not live a month. The relation which exifts between all the ftruftures of the body, and the neceflity of preferving a proper corre- fpondence of energy between the nervous, the vafcular, and the mufcqlar, ones, fince they are all connefted in the alimentary canal, at once (hows the propriety of cor¬ poreal exercife in indigeftion : for the exercife of the vo¬ luntary mufcles affords energy, not only to them, but to the involuntary movements, and gives, as is well known, much a (fi (lance to the circulatory powers. But the bodily exercife of dyfpeptic patients is a matter of nice and dif¬ ficult diferimination ; for it is well known, that, how¬ ever falutary exercife may be to a certain extent, yet that its excels tends to produce confequences direftly oppo- fite. Sleep, appetite, and digeftion, which are improved by gentle exercife, are often fufpended after violent fa¬ tigue or exertion. The weak ftate of the rnufcular fyf- tem in fome cafes is another ftrong argument in favour of medicating the degree of locomotion, and of caution¬ ing patients not to run into the common error of fa¬ tiguing themfeives, under the idea of ftrengthening their frame by ftrenuous exertions. In the firft ft age of indigeftion, and ere much debility arifes, walking during the interval of digeftion is un- queftionably the bell exercife. It is, in the firft place, P p very PATHOLOGY. 144 very agreeable, and it Teems moreover the raoli natural. There is no other accompanied with fuch a uniform and regular exercife of the mufcles and joints ; and, from the valvular ftru<5lure of the veins of the extremities, it is better fitted than any other to promote the circulation, and confequently all the functions of the fvftem. The effeil of riding on horfeback upon the abdominal vifcera is peculiar and faiutary ; and the jolting of a brifk trot Teems, without inducing fatigue, to give tone to and promote the adtion of the bowels and liver in an eminent degree. In the more advanced ftages of indigeftion, this delightful exercife becomes injurious 5 and little elfe can be borne, except the walking pace of the horfe. It is feldom, however, advifable to ride at ail at this period, fince at the pace juft mentioned the patient is fubjedled to the baneful effedl of diminifhed temperature. It is better therefore to indulge in the eafe of a carriage ; and, as this becomes too irkfome from its vibratory motion, failing is a gentler mode of exercife. It has the credit of being ferviceable in almoft all cafes of debility, and has been found particularly fo in debility of the ftomach and bowels. But even this exercife, except in warm weather, is unadvifeable on account of the expofure to cold air. Whenever thefe paflive exercifes cannot be borne, the dyfpeptic may find much relief from the ufe of fridiion, as he likewife might experience from the refrefhing prac¬ tice of champooing ; wdiich, unfortunately however, is unknown in this country. Thereafter will find the fubjedl of paflive exercife well treated of in Dr. J. Johnfon’s work on the Atmofphere and Climate of Great Britain, p. 197, & feq. We extradl a portion, in which however it will be feen that the learned author differs in fome meafure from the view's we have taken in regard to exercife after meals. He fays, “ During geftation, for inftance on horfeback, the fto¬ mach, liver, inteftines, indeed the whole digellive appa¬ ratus, experience a fucceflion of (hocks, which develop the tonicity of thefe organs, and favour the exercife of their fundlions. If the ftomach be empty, geftation awakens the digeftive powers, whets the appetite, and induces hunger: if that organ be moderately filled with food, the whole chylopoietic fyftem, enlivened by gefta¬ tion, executes with greater facility, promptitude, and per¬ fection, the elaboration of nutritive matter; and the whole fabric receives, in confequence, an acceflion of ftrength. Hence people afflidted with anorexia, or diffi¬ culty of digeftion, experience the moft marked benefit from paflive exercife, efpecially if ufed before the hour of repaft. When ufed by them after meals, it muft be mo¬ derate in degree, and gentle in manner. Thus we every day fee invalids, to whom digeftion is a painful procefs, efcape the feelings of fatiety by a gentle ride on horfe¬ back or in a carriage after dinner. In this refpedt muf- cular or adtive exercife differs eflentiaily from geftation. To run, to dance, to play at cricket, immediately after eating, is to aflail the ftomach with violent fuccufiions which derange the natural order of its movements, and diffipate on the voluntary mufcles thofe vital forces and energies which ought to be concentrated on the organs of nutrition. “ But it is not on the procefs of digeftion alone that geftation exerts a beneficial influence. It enlivens the whole abdominal circulation of blood, but particularly that of the various branches of the vena portarum. It thus affedls the hepatic fyftem, facilitating both the fe- cretion of the bile, and its elimination from the dudts of the liver into the duodenum. It increafes the periftaltic motion of the inteftines ; in confequence of which, the chyme is prefented with greater regularity and rapidity to the mouths of the ladleals, and the chyle is poured, in a freer current, into the blood-veflel fyftem.” When thefe meafures fail, when exercife does not in¬ duce thofe trains of adlion which lead to health, and when the abftradtion of noxious particles of diet fails in the fame purpofe; it becomes neceflary to have recourfe to medicine. It feldom happens, however, but that dyf- pepfia alone will yield to the meafures above mentioned : when it does not, we fhould be always fufpicious of the extenfion of the difeafe. The bowels are, as we have be¬ fore fliown, the parts moft difpofed to participate in the difeafes of the ftomach ; and therefore our treatment fliould not unfrequently be direfted to them. Indepen¬ dently however of the implication of the bowels in the common afteflion, the adlion of certain medicines on thefe vifcera is beneficially exerted on the fecretions of the ftomach and liver. Purgatives promote thofe fecretions in two ways : by the mechanical ftimulus derived from the periftaltic motions of the bowels, and through the medium of that fympathy fo remarkably obfervable in the continued mucous ftrudlures. The proper ufe of ape¬ rients is a fubjedl of great importance at all periods, and in all dates, of indigeftion. In the period under conii- deration, their objedl is merely to fupport a regular adlion of the bowels, which, as the fecretions of the whole canal are inclined to fail, and the ftomach and upper bowels do not difcharge their contents fo readily as they ought to do, fhould be rather freer than in health. Different ape¬ rients fu it different conftitutions.. For the purpofe of fupporting a regular adlion of the bowels, we recommend pills compofed of ipecacuanha, compound extradl of colo- cynth, and foap, with the addition of a little gamboge when they are not fufficiently adlive, to be taken occafion- ally at bed-time. But we abound fo much in forms of aperient medicines, that it were wafting time to mention many of them in this place. It is a common pradlice to give fome form of mercury to patients labouring under indigeftion ; and, in confe¬ quence of the ftimulus this mineral exerts on the liver, its ufe is generally beneficial ; but as a Ample aperient it fhould not be reforted to, and that for two reafons : the firft, that it exerts a prejudicial influence on the fecretion of the gaflric juice ; and fecondly, becaufe it has the effedl of often doing more than we require 5 as for inftance, when it falivates (which it will fometimesdo in very fmall quantities), or when it excites ftrudlures undifeafed, and thus deftroys the balance of adlion to the reftoration of which our endeavours are ofteneft diredted. The ufe of aperients alone is not however always fuf- ficient. The difordered fecretion of the ftomach conti¬ nuing, it becomes neceflary to excite the fecreting veffels by artificial ftimuli, for the purpofe of altering their adlion on the blood, and cauiing them to elicit more appropriate fluids ; as well as of exciting the mufcular fibres and ttie nervous expanfions to carry off their load. Among thefe, bitters hold the firfl rank. Thofe in common ufe are — gentian, chamomile, bitter orange-peel, wormwood, co- lumba, and bark. We are not of opinion that much dif¬ ference exifts in the merits of thefe vaiious fubftances. Many pradlitioners ufe one or the other of them exclu- fiveiy, and perhaps with nearly equal fuccefs. It feems that the chamomile, orange-peel, gentian, and worm¬ wood, are lefs inclined to promote the general circulation ; and are therefore preferable when a plethoric ftate of fyf¬ tem is obfervable. On the other hand, the cafcarilla, columba, and the Peruvian bark, exert a more general influence on the fyftem; and are therefore proper when, from the irritation of the nerves of the ftomach, the cere¬ bral mafs communicates too languid an impreffion to the circulating fyftem. It is generally found advifeable to combine bitters and aperients. A formula confifting of fix drachms of com¬ pound infufion of gentian and of the fame quantity of in- fufion of fenna is of this kind: it is generally found to promote all the procefles of digeftion and abdominal excre¬ tion. The combination of falts with the fame bitter in¬ fufion is likewife a common and excellent formula. It is often requifite to adminifter ftimuli derived from the mineral kingdom. Of thefe the mineral acids, the preparations of iron, and the fulphate of zinc, are in common ufe. Of the mineral acids, the fulphuric is per¬ haps PATHOLOGY. haps the beft in indigeftion, and has this advantage over the other forts, that it operates more diltinftly on ano¬ ther part affefted in dyfpepfia, viz. the (kin. It is pecu¬ liarly ferviceable in thofe cafes, u here fweating, which is not unufual, is tooealily induced by exercife ; for much tendency to fweating indicates relaxation, not vigour of the Ikin. There are few cafes of indigeftion in which iron is not found more or lefs ufeful at an early period, if no ten¬ dency to the fecond ftage of the difeafe has fliown itfelf. Its goodeffefts are increafed by combining it with bitters and aromatics ; and, in idiopathic indigeftion, the carbo¬ nate has appeared to us its beft preparation, provided it can be taken fcruple-dofes, without producing a feeling of heat and oppreflion in the ftomach. In the opinion of many, the fulphate of zinc given in very fmall dofes, alfo holds a diftinguifhed place among thefe medicines. It may be given at later periods than iron, but it requires caution; and, if its good effefts do not foon appear, fhould be laid afide. It is one of thofe powerful agents, which mult always be employed with fome degree of fuf- picion. The medicines we have fpoken of hitherto feem prin¬ cipally to exert their influence on the contraftility of the mufcular fibre, or the capillary veflels. But, as we have before feen that, however various may be the caufes which aft on the mufcular fibres of the ftomach, or on its nerves; yet thefe powers are fo connefted, that whatever impairs the one neceffarily affefts the other; fo we (hall find that a fimilar obfervation applies to the means of re¬ lief; that thofe medicines which tend to reftore a healthy nervous power to the ftomach, tend likewife to form the food into that fubftance which is beft fitted to excite the mufcular fibres of this organ ; and that whatever excites the natural aftion of thefe fibres, tends to relieve the nerves from uneafy impreflions, and, in the moft favour¬ able way, to bring into contaft with their extremities the food on which they are to operate through the interven¬ tion of the fecreting veflels. There are fome remedies which aft peculiarly on the nervous fyftem of the ftomach. Thefe are irritants, or thofe which increafe the production of the nervous power ; and anodynes or narcotics, the eft'eft of which is to dull the fenfibility. The potent nature of the firft clafs is fliown by their exhilarating effefts on the fyftem at large. It is thus that diftiiled fpirits and aromatic tinftures pro¬ duce fo much alleviation from the uneafy fenfations of dyfpepfia. It is well known, however, that the meafure of vigour which fpirituous potations afford is generally followed by increafed debility ; and we (hould therefore be cautious in the exhibition of them. They can be given with fafety only under the following circumftances ; viz. when patients have fo long indulged in their ufe, that we have to fear the increafe of dyfpeptic fymptoms from the fudden relinquilhment of the habitual ftimulant, or when we have fo far correfted the date of the other vifcera and of the fyftem in general, that the ftomach feems only to want fome additional nervous excitement to call its na¬ tural aftion into full play. Even when exhibited with thefe intentions, it is beft to give fpirits only in conjunc¬ tion with bitters, and in fmall dofes. This rule does not of courfe apply to violent or fpafmodic paroxyfms of dyf¬ pepfia, in which fomewhat aftive dofes of diftiiled fpirit are often admiftible. When combined with bitters, the medicines of this clafs render the former medicaments more permanent in their eft'eft ; and indeed, the aftion of the latter feems often neceffary to enable the ftomach to bear the former without oppreflion. The quantity of diftiiled fpirits in fuch mixtures (hould always however be fmall ; a twelfth, at moft an eighth, of the whole. In the exhibition of aromatics lefs nicety is required: the pro¬ perties of all are fimilar, though fome fuit the ftomach and the tafte of individuals better than others. Thus ginger may be ufed when cardamoms ftimulate the fyftem 145 too much ; and cardamoms will relieve flatulence and fpafmodic pains, when ginger fails. Among the drugs which augment nervous fenfibility, we have to mention ammonia. The operation of this fubftance is by no means Ample. It accelerates the pulfe for fome time after reception into the ftomach, while it ftimulates the contraftile fibres of that vifcera, and is alfo a grateful and permanent ftimulus to its nerves. It is well calculated to relieve thofe patients in whom the force of the circulation is below par ; provided, how¬ ever, that no tendernefs of the epigaftrium, hard pulfe, or any lenfation of burning in the hands or feet at night, is experienced ; for the latter fymptoms would undoubtedly be formidably augmented by its adminiftration. Cam¬ phor poffeffes fome of the properties of ammonia in a (lighter degree. Its property of alleviating ficknefs ren¬ ders the nuftura camphorae a good vehicle for other me¬ dicines. We have recommended much caution in the ufe of ir¬ ritants : the ufe of anodyne remedies demands perhaps ftill more. The only medicine of this clafs which produces * effefts worth notice is opium. In violent fpafms this medicine may be given fomewhat freely ; but Dr. Philip fays, that very fmall dofes,* two or three minums of tinc¬ ture of opium for example, repeated two or three times a-day, often prove highly ferviceable in allaying morbid irritation ; their conftipating eft’eft is eafily counter- afted ; and fometimes indeed they have very little of this efteft. A better mode of exhibiting opium is under the form of the Pulv. ipecac, comp. From two to four grains of this preparation, given every fix or eight hours, appears to have a peculiar efteft in allaying the irritation attending indigeftion, which probably arifes from its aftion on the (kin. It appears to be beft adapted to thofe cafes in which that combination of languor and reftleff- nefs, often fo remarkable in this difeafe, prevails. It is better from time to time to difcontinue and renew its ufe, than to exhibit it for a great length of time without interruption ; which, even when the dofe is very fmall, is apt to occafion fome confufton or other uneafinefs of the head ; an efteft which goes far to increafe eventually all the dyfpeptic fymptoms. While thefe remedies are then in aftion, we ftill have to contend with paroxyfms of pain and nervous irrita¬ tion. To thefe, opium, ether, cardamoms, and the whole hoft of antifpafmodics, are the ufual and effeftual reme¬ dial agents. Among thefe means of temporary relief, very-warm water holds a higher place perhaps than is ge¬ nerally fuppofed. To its frequent ufe there are the fame objections as to other powerful ftimulants ; but occafion- ally it relieves dyfpepfia in a very decifive manner. It de- ferves mentioning, although it is difficult to explain it, that a confiderabie degree of heat applied externally to the region of the ftomach is as effeftual, provided it be continued for a fufficient length of time, in removing cramp, as any application of heat we can make internally. It is alfo frequently relieved by heat applied to the feet. It is during this ftage of dyfpepfia that galvanifm is often advantageous ; but in the ufe of this ftimulant we muft be careful to regulate it fo that it may not excite inflam¬ matory (ymptoms. When the bowels become implicated in the difeafe of the ftomach, a more briik and continued date of purging is required. To fpafmodic affeftions of thofe parts the fame fpirituous remedies that relate to the gaftric affec¬ tion are applicable. When, from the fullnefs of the right hypochondrium unattended by deficiency of bilious fecretion, we have realbn to fuppofe tardinefs of aftion in the duodenum, thofe purgatives which excite the periftaltic motions are preferable to all others. Of thefe, the combination of rhubarb and fenna may be mentioned as one of the beft. When, on the other hand, mucous feeretions are apparent to excefs in the faeces, the faline cathartics (hould be em¬ ployed. 2 PATHOLOGY. 146 ployed. We referve, however, further remarks on the due regulation of the bowels till we come to the next genus. The functional derangement of the liver occurring as a confequence of dyfpepfia, requires the particular treat¬ ment of the former complaints to be conjoined with that of the latter difeafe. The medicine bell calculated to promote the fecretion of bile is mercury. The different preparations of this mineral may be ufed according to the peculiar conftitution of the patient. The moft common are Abernethy’s blue pill, Plummer’s pill, and calomel. The firft of thefe, given in dofes of four or five grains every fecond or third night, as recommended by Mr. Abernethy, is particularly ferviceable in thofe cafes where the affection of the liver has fupervened early, and where, confequently, it is the principal caufe which fup- ports and aggravates the dyfpepfia. This pill difagrees however with fome conftitutions. We do not allude to the tranfient fenfation of pain which is felt in fome fto- rnachs for the firft half-hour after its reception ; but the more permanent fenfations of the fame kind that are fome- times experienced. Calomel is perhaps, after all, the belt kind of mercurial for the firft ftage of indigeftion ; and is chiefly applicable when irregularity of the fecretion of bile is prefent. It alfo deferves notice that calomel ne- ceffariJy occafions brifk purging, on which the benefit derived from it often greatly depends ; fo that, while, by its peculiar effedl on the firft paffages, it excites a better action of the liver, by its purgative effedl it tends fur¬ ther to emulge the gall-du&s, and relieve the diftended ftate of the liver. Its operation, then, is moft wanted where this diftention is greateft, which may be known, we have feen, by the ftate of the right hypochondrium, and will be Jeaft injurious where the ftrength is moft able to bear fo confiderable a call upon it. When there is little diftention of the liver, and the ftrength is much reduced, the operation of the blue pill, provided it agrees tolera¬ bly well with the ftomach, is preferable. The relief ob¬ tained from it may be lefs fpeedy, but it will be obtained at lefs expenfe to the conftitution. Inftances frequently occur of the bad effedts of not attending to this difting- tion. What is only a falutary evacuation in one cafe, is an overpowering caufe of debility in another. Plummer’s pill often fits well on the ftomach when both of the former preparations of mercury fail. The propor¬ tion of antimony in its compofition tends to caufe its in¬ fluence to be exerted on the Ikin as well as on the liver ; and hence in the cure of cutaneous affections it is held in merited eftimation. As the effedl of mercury is only required to be tran¬ fient in the firft ftage of dyfpepfia, whatever form of the mercurial remedy we employ fliould be carried off by an aperient, either given with it or at a proper interval after¬ wards. Of thefe alternatives, we fliould (with the excep¬ tion of peculiar cafes) incline to the latter; for it can¬ not be queftioned, that much larger dofes are required to promote the hepatic fecretion when combined with the dry purgatives, as colocynth, aloes, &c. and we have feen cafes where it failed entirely to produce fuch effedl. In the milder form of difeafe we are now fpeaking of, a draught of falts and fenna, taken in the morning after a mercurial pill the over night, will we think be found the leaft painful or debilitating in its operation. When mer¬ cury occafions much irritation of the bowels, its conti¬ nued ule brings on a degree of dyfentery. The patient is tormented with griping and tenefmus, and at length paffes little befides mucus, often mixed with a fmall quantity of blood. In fuch cafes, we mull difcontinue its ufe for a fliort time ; and when we find, as fometimes happens in fuch cafes, that on returning to it the fame fymptoms conftantly recur, and cannot be prevented by changing the preparation, or the ufe of anodynes and mucilages, it muff be entirely laid afide. Given under the above regulations, mercury is a very excellent remedy for the hepatic derangements of indi¬ geftion. Its indifcriminate ufe undoubtedly does much harm ; and there can be little doubt that various kinds of “ antibilious pills” (as they are foolilhly called), which are daily vended in great quantities, do upon the whole more harm than good. Indeed this muft always be the cafe with patent medicines ; no medicine can be energe¬ tic, unlefs it has the property of inducing derangement of fome part ; and therefore, if the production of a de¬ rangement from the natural ftate be not properly di¬ rected, much mifchief muft enfue. The indifcriminate ufe of mercury in gaftric complaints has called forth thefe remarks j and we with particularly to repeat to our me¬ dical brethren a faCl well eftablilhed by the teftimony of the bell authors ; that mercury Ihould hold no place in the treatment of Ample indigeftion, while the fecretion of bile is unchanged ; and that, when that change has occurred, its cure Ihould be effeCled by the leaft pofllble quantity of this potent mineral. As mercury fometimes ir¬ ritates the fyftem at a rate not balanced by its beneficial influence, it becomes neceffary to fearch for a fubftitute which may be employed inilead of it. The combination of the nitric and muriatic acids, taken internally or ufed externally, as Dr. Scott firft recommended, has appeared to us the moft fuccefsful. See Nitro-Muriatic Acid, vol. xvii. p. 104. With refpedl to the more diftant affedlions arifing from dyfpepfia, we have before Ihown, that, numerous as they are, they are for the moft part the products of nervous ir¬ ritation ; hence depletion has little effect on them. When they are of that violent and uncontinued charafter which we have called, after Dr. Hall, the Mimofis urgens, antifpafmodics, as mulk, valerian, ether, emetics, &c. are the remedies indicated in addition to the ufual dyfpeptic treatment. The fame remark applies to the fpafrnodic dyfpncea,palpitatio cordis, &c. When more permanent ef¬ fedts feem induced,counter-irritantsareofelfentialfervice. The affections of the head which occur in indigeftion require more particular notice. We fliould be par¬ ticularly careful to keep the circulation rather below than above the ufual llandard in cerebral affedlions, be- caufe of the formidable difpofition to inflammation which they frequently and fuddenly affurne. On this account, when the pulfe does not forbid it, and the cerebral is not relieved by the excitement of fecretion in the gaftric ftrudture, topical bleeding is the moft advifable ftep. This fliould be followed by the fliower-bath, an agent at once exciting the Ikin and depleting the cranial circula¬ tion. This pradtice is ufeful in the ftate of erethifm which we before noticed as defcribed by Dr. Nicholl. That author recommends the ufe of the pulv. ipecac, comp, but a fpecimen of the difeafe we lately faw feemed in- creafed in violence after each exhibition of the above me¬ dicine. On the whole, topical bleeding, a cooled ftate of the external part of the head, the abllradlion of ftrong light and of all irritating irnprellions from without, tole¬ rably free purging, and the ufe of diuretics, are the beft modes of treatment. In all head-affedtions, free dif- charges from the inteftines and bladder are ftrongly re¬ quired. In the head-ache of the firft ftage, emetics give temporary relief; but particular care is required to note the diagnoftics, as ftupor, or throbbing of the temples, w’hich tend to fliow eftablilhed difeafe in the head. When tills occurs, or indeed when inflammation is-sfet up in any ftrudture, the ufual treatment of the phlogoticiK null be combined with that in queltion. The connexion between the functions of the Ikin and alimentary canal has been often adverted to. The former ftrudture affords an excellent mean for relieving the dif- orders of the latter. Thus the medicated bath recom¬ mended by Scott is a more powerful agent in improving the fecretion of the ftomach, liver, and bowels, than the internal ufe of the acid. But the chief meafure adting on the fkin is the bath. Cold bathing is an old remedy in indigeftion. It is feldom fafe, however, in nervous or debilitated lubjedls. Where its ufe can be borne, a fliort plunge 147 PATHOLOG Y. plunge is the beft mode of applying it; and much care lhould be taken that perfect drynefs, and indeed re-aftion, of thelkin, be produced, by rubbing with dry cloths. In fome cafes fponging only, followed by the lame fri&ion, is the furtheft attempt at cold bathing which the delicacy of our patients’ conftitutions will allow us to make. The warm bath does not require the lame limitation ; and it deferves in our opinion more confideration than it .generally obtains. A gentleman of much experience, .Dr. J. Johnfon, is of the fame opinion ; he obferves that, .if the general ufe of the warm bath lhould ever become prevalent in this country, it will produce a more bene- .licial revolution on the health and longevity of the in¬ habitants, than any change which the hand of time has ever wrought; and that, fo far from weakening or ener¬ vating the conftitution, it has a decidedly contrary ef¬ fect ; and therefore, in debilitated fubjeffs, it is infinitely more proper and fafe than the cold bath. Indeed the good effe£ts of the. latter refult from the re-aftio'n of the fyf- tem ; but, as this re-affion is entirely an effort of the con¬ ftitution itfelf, to refill as it were, or undo, what the cold immerfion had produced, a confiderable degree of vital .energy is necelfary ; otherwife fome internal vifcus may fuffer. On the contrary, fays Dr. J. the warm bath elicits the blood to the furface of the body,' with hardly any of that re-acfion obferved after the cold bath. The whole contaneous fyftem of velfels is thus filled with blood, while the velfels of the interior organs are relieved, and that without any particular exertion of the heart which might render it liable to fubfequent exhauflion. The fpirits too are railed, the pulfe mended, and the appetite jncreafed; in Ihort, a general renovation is felt through¬ out the whole frame ; an effedl more remarkably ob¬ served after exhauflion or fatigue. The oriental nations have long appreciated its virtues in this refpedl. Homer defcribes Ulyffes, among others, as refrelhing himfelf with the warm bath, on his return home ; and the nume¬ rous and fplendid baths, by the building of which the Roman emperors gained fo much popularity, will fhow that this comfort, or luxury, was no lefs elteemed in the weft. The warm bath will by no means be an effedlual reme¬ dy in dyfpepfra, unlefs the immerfion in it be of much longer continuance than, is ufual in this country. Dr. Thomas, a pra&itioner who has fpent fome time abroad, informs us, that “ upon the continent, where fo much good is produced by this powerful remedy, no one thinks of recommending a patient to flay lefs than an hour in the warm bath ; and at UfTat, where fo many cures have been effedled by means of- the bath, and by fuch means only, I have known many weakly delicate patients take two baths of one hour each every day for three weeks without intermiffion ; and I have no doubt in my mind, and the fame conviflion pervades medical men in general in France, that it is owing. to this manner of taking the warm mineral baths, that fo much. good is effefted by that remedy; and, by parity of reafoning, I may fay, that little good is obtained from them in this country, becaufe there is not fufficient time allowed for bathing.” . The vapour-bath is alfo a remedy of great efficacy in the complaint in queftion.- „ Thedifeafes for which the warm bath may be employed, are much more numerous than thofe where the cold bath can be exhibited with fafety. And in faft it may be ufed on moft occafions without premifing the accurate difcri- mination required ere we adopt the critical meafure of cold bathing. See the article-BATHiNG, voi. ii. p. 803. On the; treatment of the Jccond Jioge of indigeftion, we have feen that, after a certain period, a- change takes place in the nature of dyfpepfia; that a difordered ftate pf the circulating velfels of the ftomach fupervenes to fufpenfion of nervous influence and of mufcular propul- fion ; that this change happens at various periods, fome- times in a few days or weeks, but that not unfrequently it is not manifefted for many months, more rarely for ,t VOL. XIX. No. iz9i. * years ; that this ftate is characterized by a change in the phenomena of the circulating fyftem, indicated by a hard pulfe; and that there is likewife pain in the ftomach. •We confider thefe fymptoms as indicating chronic inflam¬ mation of the ftomach; and we may remark, that this opinion is borne out by analogical reafoning on what takes place in other parts, and by the diffeffions of the more marked cafes which are recorded by foreign practitioners. We have therefore to reduce inflammation ; and of courle the flimulating meafures which we have ufed in the firft ftage of indigeftion are to be laid alide ; but, in ad’opting the oppofite or antiphlogiftic treatment, we inuft confider that the ftoma'ch is the feat of complex functions; and that, though inflammation has fupervened, nervous de¬ rangement and mufcular inaftion ftill remain. More¬ over, the periodical affioh of the ftomach, and its conftant expofure to irritants, render general or fudden depletion of the contents of its velfels of little avail, lince, how¬ ever the latter may be depleted, and however perfectly they may recover their natural diameter, the frequent fti- mulus of foreign fubftances will tend to reproduce the morbid ftate of vafcnlar fullnefs. The impeded nutrition which is prefent caufes a debility of the fyftem quite ob¬ noxious to vafcular depletion. The treatment of this ftage of dyfpepfia requires therefore particular attention, inafmuch as we have to reduce inflammation by one train of precedes, and produce mufcular and nervous action by another. As thefe are incompatible indications, the lefs mult give away to the more important; that is to fay, wemuft reduce the inflammatory adtion firft, and confider the mufcular and nervous debility afterwards. The for¬ mer intention muft be effected by applying leeches to the epigaftrium, by cooling applications, as effervefeing draughts and folutions of nitre, cold water, See.' and by a very abftemiotis vegetable diet. When thefe mea¬ fures are luccefsful, we may cautioufly return to the ufe of bitters, &c. and thereby endeavour to remove the 'caufes, i. e. morbid diftention and diminilhed nervous power, which have produced the difeafe in queftion. When the inflammatory ftate has not continued long, and has not appeared till the nervous indigeftion has been of long Handing, we generally prognofticate its removal by the above-mentioned means with certainty; bur, in propor¬ tion as it becomes more thoroughly eftablithed, we lhall find lefs marked relief from the bleeding, and a much more aggravated and fudden return to inflammation when we attempt to ftiipulate by bitters. It is at this period of indigeftion that ipecacuanha is an excellent remedy. The effect of this lubftance is to produce fecretion from the ftomach, though, it muft be allow'ed, not that which is commonly called the gaftrlc juice ; the nature of that fluid, or at lead: its peculiar ef¬ fect on the nervous expanfion, being altered. That fe- cretion is an excellent means of removing local plethora is well known ; and hence appears the advantage we de¬ rive from this drug. In regard to its dole, we fhouid give as much as induces fecretion without caufing naufea, a phenomenon which tends to debilitate the mufcular fibres of' the ftomach. A grain and a half, two, or in fome cafes three, grains will be fufficieht. It is necelfary, however, to produce fecretion from a more extenlive furface than the ftomach itfelf: the bowels fhouid be kept in an open ftate, and the hepatic fecretions lhould likewife be pro¬ moted. . In taking the firft ftep, we lhould employ thofe purgatives which produce the leaft pain or irritation in their operation. Vegetable diet, which we have before fpoken in commendation of, will in many cafes relax the bowels; but, where this effect is not produced, aperients muft be given. They fhouid be of a mixed kind ; they fliould comprehend many ingredients of this numerous clafs, avoiding however fuch as produce nervous irrita¬ tion. We have commonly recommended, when it is fuf- ficiently aitive, the Confectio fennte; but many other formula will no doubt anfwer the purpole equally well. Of courfe, when one part of the bowels is more fliig Q ft gilh 148 PATHOLOGY. gifli than another, we Should endeavour to excite it by purgatives which aft fomewhat exclusively on it ; as, for inftance, rather more rhubarb mult be administered when the duodenum feems inaftive.&c. The number of mo¬ tions mud be fomewhat regulated by the Strength, &c. but three in the courfe of the day will feldom be too many. We have noticed, that, when the firft Stage of indigef- tion has continued for Some time, the funftion of the liver becomes disordered. A greater or lei's tendency to diforder in this organ, alter it once appears, always con¬ tinues throughout the difeafe, l'o that it is a condant attendant on the Second Stage ; and tiiofe medicines which influence the Secretion of this organ, therefore, always form part of its treatment. Of thefewe Still find mercury by far the moSt efficacious. Several circumstances, how¬ ever, render caution, in the ufe of this medicine, even more neceSTary in the Second than in the firll Stage. Not only has the greater continuance of the difeafe occasioned a greater lofs of Strength ; but its increafe, and the change which has taken place in its nature, renders it neceSTary to employ this medicine for a longer time, and often in a way that more direftly influences the State of the con¬ stitution. In the firft Stage, as we have Seen, we want only the transient efFefts of this medicine on the liver. On the other hand, we now want to induce a more permanent change in the difeafed State of that vifcus,.and rather to reltore the altered properties of its Secreting vefl'els than Simply to increaSe their aftion for the fake of removing plethora. It has been lately recommended, with this view, to give mercury in very-minute and fomewhat-fre- quentdofes. Dr. Philip Says that he has “generally given a grain of the blue pill, Sometimes only half a grain, twice or three times. in twenty-four hours, till the l'ecre- tion of bile appeared to be healthy, repeating thefe dofes when it was again dilordered ; and by fuch dofes, which may appear to many little better than trifling, I have Seen the bile gradually reftored to a healthy Slate, when larger dofes had been employed in vain. They not only often Succeed where larger dofes fail, but the change, in pro¬ portion as it takes place more Slowly, feems generally to be more permanent.” We may add, that, in the Second Stage of indigestion, violent aftion of the abdominal vif- cera Strongly tends to deftroy their tone; and this forms another reafon againSt employing large dofes. of mercury, Since, by their aftion on the Secreting Surfaces, they pro¬ mote Sudden, anft debilitating evacuations; an effect very unfavourable in the weak Hate of the constitution which attends this Stage! By the above praftice we avoid the occasional ill eft'efts of mercury in a great degree, though Some practitioners of diftinftion conceive it to be fomewhat inert. Our own experience, however, is in favour of it ; and in Dr. Hall’s writings cafes are mentioned in which the like diminutive dofes of this medicine produced favourable refults. Much latitude will be allowed, however, in the ufe of mercury, Since the difference of climate or of constitution renders a dofe in Some cafes too-powerful, in others per- feftly nugatory. There can be no doubt, for inftance, that in hot climates a much larger proportion may be given of this medicine than in temperate ; and the various degrees of fufeeptibiiity to its aftion, which different in¬ dividuals exhibit, are equally well known and unaccount¬ able. When mercury disagrees with the bowels, conium, hy- ofieiamus, or extract, papaveris, maybe conjoined with it; or we may have recourse to the nitro-muriatic-acid bath as a Substitute. The latter remedy is indeed Sometimes of uSe during the intervals of ufing mercury; but it too often happens that the cathartic tendency of the mer¬ cury is increafed by the acid. The bath muSt not be u fed during the inflammatory State of the Stomach, but may be very advantageoufly preferibed when local blood¬ letting has been premifed. The degree of aftion which the nitro-muriatic-acid has to exert on the constitution is regulated by the Strength of the health, and by the extent of the cutaneous Surface immerfed, a hand ora foot being firft bathed ; and, if its eifefts are borne well, by degrees the reft of the body up to the chin. See vol. xvii. p. 106. Dr. Philip has recommended dandelion to be tiled as a Substitute for mercury in dyfpepfia. He fays that “ it ap¬ pears to poSfefs greater powers in this difeafe than are ufually aferibed to it, but it requires to be taken in very large dofes. It is belt adapted to thofe cafes, in which the bile is deficient or much disordered, while the power of the Stomach is Still considerable. In Such cafes, I have Seen the patient reftored by a Strong decoftion of dande¬ lion ufed for common drink, without the aid of any other medicine. In addition to its effeft on the liver, it tends to cool, and consequently allay the inflammatory diathefis, and often excites both the bowels and kidneys. The latter effeft, which is belt counteracted by alum, when the Stomach bears it well, is frequently fuch as to make it neceSTary to discontinue the dandelion. The former is feldom considerable, and can always be restrained. It is often given with great advantage in aid of the fmall dofes of mercury when the Stomach bears it well, and enables us further to diminish the quantity of this medi¬ cine.” The functional derangements which occur as remote confequences of dyfpeplia, are to be cured only by remo¬ ving the original difeafe. The topical inflammations re¬ quire additional remedies; for we have before noticed that, when of long Standing, they often aft as counter-ir¬ ritants to the gaftric disturbance. The liver, lungs, Spleen, and heart, are molt liable to this affeftion ; and are all to be treated on thefe principles ; viz. to withdraw nervous irritation by counter- Stimulation, to bleed locally or ge¬ nerally according to the frequency and hardnefs of the pulfe, and procure Secretions from the abdominal vifeera, and from the Skin, by the warm bath. The Same rules apply to the treatment of the head- affeftions. Here the Sympathy between the external and internal parts allows the additional ufe of cold lotions to diminish the aftion of the velTels of the head : a Simple meafure, but one of great efficacy. The ereft polture, or at lead a near approach to it, Should likewise be infilled on ; and a more aftive kind of purging than in the derange¬ ments of the abdominal vifeera. The erethifmal State of the brain Should be treated with continued counter-irrita¬ tion, and with much alfiduity; Since, when once it has apoplexy, this latter calamity is generally fatal, and ap¬ pears uninfluenced by bleeding or any other known means of relief. In the gouty and rheumatic affeftions of this Stage of indigeftion, in addition to the ufual means, the Colchi- cura is by no means a defpicable remedy. Indeed, where this drug agrees, it Seems to reduce both the arthritic and the gaftric inflammation at the Same time. The ufe oS an anodyne liniment likewife affords temporary relief to the rheumatic pains. When the inflamed Slate of the mucous membrane has been communicated to the bowels, and piles, Strifture, or tendernefs along the courfe of the ccecum, are prefent, the molt efficient method of relief is anal leeching. This praftice has not obtained in our country the attention it deferves, though the great benefit our continental neigh¬ bours derive from it, Should have taught us its common ufe long ere this time. We find Some prejudice oppofed to it; but, if properly condufted, it is by no means un- pleafant or indelicate. The leeches may be applied to the fundament by means of a glafs formed like an eye-glafs, but of larger dimenfions ; and, after they have laid hold, the patient Should fit over a bidet, and by the warm va¬ pour or by ablution promote the difeharge of blood. We have found this method more fuccefsful than even leech¬ ing over the epigaftrium, where tendernefs of the part is prefent ; and it has this further advantage, that, from the nature of the Sanguineous distribution, it direftly depletes the whole abdominal vifeera. Pain 149 PATHOLOGY. Pain in the courfe of the colon is often relieved by fric¬ tion with a liniment, by fuppofitories and clyfters. Be¬ fore leeching has been ufed, the inflammatory (late of the bowels is rather increafed than relieved by cathartics; and, after it, thofe only of the mildeft nature fliould be had recourfe to. The fubjeCfs of mtelena, diarrhoea, See. which would naturally follow here, mult be deferred till our nofologi- cal arrangement brings them before us. When inflammation of the mucous membrane of the lungs is connected with Dyfpepfia, we have a very power¬ ful agent in the hydrocyanic acid. This remedy has in¬ deed been preferibed with fuccefs by Dr. Elliotfon for the relief of all dyfpeptic fymptoms dependent on dif- turbed nervous power; but we have not introduced it into our lift, as we have not been able to colleCt, from mere general experience, the like favourable teftimony of its virtues ; and it is fo potent a drug, that we would not hazard its occaftonal deleterious effeCts, fince the correc¬ tion of the firft ftage of dyfpepfia may generally be ac- compliflied by milder meafures. In the. removal, how¬ ever, of bronchitis, this acid muft be regarded as an im¬ portant agent, and one which at the fame time perhaps relieves the original fourceof difeafe. It is given in the dofe of half a minim at firft, and this is- gradually ex¬ tended in proportion to the efteCt obferved from it. Of courfe this complaint requires more ftriCt attention to the purity of air, the regulation of temperature, and the perfpiration of the Ikin, than other forms of the dyfpeptic Sympathies. It is generally accompanied with hepatic derangement; and on this account is ufefully treated by i mall dofes of calomel, perfevered in until a healthy bilious difeharge is feen in the (tools. The cacbeCtic difeafes of indigeftion require in general a very remarkable change in the diet of the invalid ; nor does itfeem that we need in thefe cafes fo particularly re¬ gard the fpecies of change, fince an alteration of whatever kind is generally found ufeful : thus, a meat-diet will produce a cachectic date of blood in fonie, as a vegetable diet will in others ; and a change is in either cafe clearly indicated, both by reafon and experience. We (hall take up this fubjeCt under the head Dyfthetica. The chlorotic indigeftion mentioned at p. 139, requires in general a more generous diet and more active exercife ; and as, in females, the uterus is often implicated in the difeafe, fteel, aloes, See. are appropriate remedies. The connection between urinary gravel and indigeftion does not lead to any difference in the ufual plan of cure ; fince, from whatever caufe gravel may arife, it will re¬ quire a peculiar treatment. It is worthy of remark, how¬ ever, that beer, efpecially if ftale, will caufe the depofition of fabulous matter; while fpirits, efpecially alcohol, di- minilhes this tendency in a remarkable degree. Thefe facts are of courfe of moment in relieving the fymptoms in queftion. In the ufe of all thefe meafures, and in their application to the various forms of dyfpeptic derangement, the prac¬ titioner (hould endeavour fo to conjoin them, and adopt their ufe to the idiofyncrafy of his patient’s conftitution, that he may not materially difturb the balance of power in the various parts of the iyftem ; but the ufe of remedies will feldom avail much, if the primary and fundamental fources of the difeafes in queftion, viz. bad air, improper orexceflive quantity of food, and lympathetic irritations, be not removed. Genus VI. Colica, [from tuoMv, the colon ; this part being the chief feat of the difeafe.] Griping of the guts. This genus contains fix fpecies. It is characterized by griping pain in the bowels, chiefly about the navel, with vomiting and coftivenefs. The-caufes of the com¬ plaint are local irritants, whether undigefted aliment, poifon, or crude fecretions of the upper parts of the ali¬ mentary canal. Or it may, and indeed moll commonly does, arife from fympathy with a remote part; perhaps more frequently with the (kin. Seven fpecies are enume¬ rated by Dr. Good, and Cullen mentions more; but the proximate caufe of all thefe appears to be the fame; viz. fpafmodic contractions of the mufcular fibres of the in- teftines. 1. Colica ileus, (Colica fpafmodica, Cullen .) Characte¬ rized by retraCtion of the navel, and fpafms of the muf- cles of the belly. It begins with a fenfe of weight or pain, at the pit of the (tomach, attended with lofs of ap¬ petite, yellownefs in the countenance, a (light ficknels, and coftivenefs ; the pain gradually increafes, becomes fixed about the navel, from whence painful dartings pro¬ ceed in various directions ; wherever pain is felt, forenefs and tendernefs remain fome time afterwards. The fick- nefs increafes with the pain ; and, at length, a vomiting of bilious matter comes on, the function being of courle deranged by the difeafe of the inteftines. The urine is diminiflied in its ufual quantity, and a tenefmus fome- timesadds to the diftrefs. While the pain is fpafmodic, the pulfe remains unaffected, except concurring circum- ftances produce a change in it. The urine is various. If the fmaller inteftines are the feat of the pain, it is felt more acutely; if the larger inteftines are the parts ag¬ grieved, the fenfe of pain are more dull and heavy ; fome- times there is a bitter tafte in the mouth, and a yellow¬ nefs in the countenance. Sometimes the diforder limn- lates a fit of the gravel ; (tones pafling through the ure¬ ters ; rheumatic pains in the mufcles of the belly; the blind piles ; (tones pafling through the gall-duCf. Gra¬ vel in the kidney produces often colic-pains, not eafily diftinguifhable; but, when (tones pafs through the ureters, the tefticle on that fide is often retraCted, the leg is be¬ numbed, and a pain (hoots down the inlide of the thigh. Rheumatic pains in the mufcles of the belly rarely affect fo accurately the umbilical region, but dart, in various directions, to the cheft or to the pelvis, and are attended with forenefs, not confined to the abdomen. The pain from the blind piles is confined to the reCtuin; and that from a (tone in the gall-duCt is felt in the pit of the fto- mach, occafionally (hooting through the body to the back. When the diforder is purely fpafmodic, the mere alle¬ viation of the fpafm is fufticiently obvious. Ether, vale¬ rian, ammonia, opium, &c. being premifed, means are to be put in force for procuring (tools. Therefore, either foon after or in conjunction with an opiate, fome cathar¬ tic medicine (hould be adminiftered, either by the mouth or in a clyiter. If the conftipation has been but of ftiort duration, the neutral falts will generally be adequate to the purpofe of procuring evacuations ; fuch as the mag- nefite fulphas, for ir.ftance, or the fodae ftilphas : both have the advantage of being conveniently repeated at ftiort intervals, in fmall quantities, until the defired ef¬ fect is produced ; and their aCiion is increafed by their union. Caftor-oil, a mild and tolerably-certniu purgative, is the belt medicine we know of. Indeed molt painters who are aware of the utility of caftor-oil efcape the attack of this malady, to which (as well as to the next fpecies) they are very (ubjeCt, by taking a large dofe as foon as they perceive the flighted: fymptoms of the difeafe. Where ficknefs is prefent, if more aCtive means are required, calo¬ mel, combined with jalap and rhubarb, may be employed. Moreover, remedies may be applied immediately to the part affefted, by means of clyfters. Large quantities of warm water (to the extent of fome pounds), injefted by a proper fyringe, have frequently had the effeCf of remo¬ ving the pain and fpafmodic ftriClure of the colon, partly by the foothing effeCts of the warmth, and partly by me¬ chanical dilatation. Opium may alfo be adminiftered in the fame menftruum, combined with neutral falts, with confiderable advantage. Thefe emollient clyfters act alfo powerfully in aid of laxative medicines taken by the mouth, particularly where the latter are impeded in then- operation by a collection of indurated feces ; for, while the periftaltic motion of the bowels is roufed by the laxatives 3 ISO PATHOLOGY. laxatives in the upper part of the canal, the obftruflion is mechanically loofened, in the lower part, by the clyller... A folution of aflafoetida, alfo, adminiftered in this way, tends both to relieve the pain by its antifpafinodic qua¬ lities, and alfo to Simulate the lower bowel to evacua¬ tion. But, Where there is very obftinate conftipation, a clyfter of more efficacy is one made of turpentine, pro¬ perly fufpended in water by means of mucilage or the yolk of an egg. In cafes where every purgative medi¬ cine has failed, and the moll powerful clyfters have proved ineffedlual, the aflion of the bowels may be exci¬ ted by throwing cold water on the lower extremities. When inflammation does not feem likely to occur, and powerful cathartics are required, the oil of croton will be found a remedy of great avail. It is of much importance, however, to diftinguifh fpafm from inflammation of the colon, with which it is Sometimes connected, and into which it is likely to run. In faff, this always happens before a fatal termination takes place. :i nut The former is thus diftinguilhed from the latter pffeffion. The fymptoms, which imply the fpafmodic Hate, are a foft pulfe of natural or of little-increafed fre¬ quency; the pain intermitting occafionally, or moving from pne part to another, and being, relieved, or at leaft not increafed, by external prefl’ure, and the occurrence of feculent evacuations, though the lattercircumftance is ieldom to be relied cn. The fymptoms, on the contrary, which lead to a fufpicionof inflammation, are, unremit¬ ting feverily of pain, obflinate conftipation, tenfion of the abdomen, and an aggravation of the pain by preflure; a very-frequent fmall and bard pulfe; the Ikin being hot and dry, or partially moift with clammy fweats ; frequent retching, with a dry brown tongue, hiccup; and, above all, pain in the head, or difturbance of the cerebral func¬ tions. Where inflammation is threatened, recourfe fhould be immediately had to the lancet, and a free bleeding from the arm, from a large orifice, fliould be effedled. In ple¬ thoric habits, this operation may require to be repeated, if the pain fliould not remit,' and the pulfe fliould remain hard and frequent, and if the blood drawn fliould exhibit the huffy coat or contraftion of the coagulum. Where the fymptoms of inflammation are lefs violent, leeches to the abdomen, the warm bath, fomentations, or a blifter, may be applied. In ftrong habits, indeed, if the pain lias been of confiderable duration, inflammation isalways much to be apprehended ; and a moderate venefeftion may be beneficially employed in anticipating its aftual attack. The tobacco-clyfter is likewife ufeful in violent cafes ; but the dreadful effefts this agent is capable of producing fliould render us very cautious in the ufe of it. Of courfe, opium, an excellent remedy in the fpafmodic colic, fliould be entirely profcribed in this. In the aggravated form of this attack, afymptom arifes which gives name to the difeafe; namely, the ftercora- ceous vomiting, or iliac pajfim. In it the periftaltic mo¬ tions of the inteftines are totally inverted, and all their contents, even clyfters, will be vomited; a circumftance always to be accounted highly dangerous; but, if the paflage through the inteftines be free, even though their periftaltic motion fliould be inverted, there is much more hope of a cure than when the belly isobftinately coftive, and there is fome fixed obftruftion which feems to bid defiance to cathartic remedies. Introfufception, ulceration, mortification, See. are the ultimate confequences of the inflammatory procefs ; oc¬ currences for the moll part fatal, or at leaft only deriving alfiftance from furgical operations. A very feverc kind of colic is produced by the poifon of- lead. It is our next fpecies ; viz. 2. Colica racbialgia, (C. Piftonum, Cull.) The colic of Poitou; otherwife called the painter’s or Devonlhire colic. In this difeafe the pain is at firft dull and remitting; but ' progreflively growing more violent and continued ; ex¬ tending to the back and arms, and at laft producing pa- ralyfis. We copy the following more detailed account of its fymptoms from the Encyclopaedia Britannica. “ The patient is generally firft feized with an acute pain at the pit of the ftomach, which extends itfelf down with griping pains to the bowels. Soon after there is a dif- tenfion, as with wind ; and frequent retchings to vomit, without bringing up any thing but fmall quantities of bile and phlegm. . An obftinate coftivenefs follows, yet fometimes attended with a tenefmus, and the bowels feem to the patient as if they were drawn up towards the back ; at other times they are drawn into hard lumps, or hard rolls, which are plainly perceptible to the hand on the belly. Sometimes the coats of the inteftines feem to be drawn up from the anus, and down from the py¬ lorus, towards the navel. When a ftool is procured by artificial means, ds clyfters, &c. the feces appear in little hard knots like ftieep’s dung, called Jcybala, and are in •fmall quantity. There is, however, ufually an obftinate coftivenefs ; the urine is difeharged in fmall quantity, frequently with pain and much difficulty. The pulfe is generally low, though fometimes a little quickened by the violence of the pain ; but inflammatory fymptoms very feldom occur. . The extremities are often cold; and fometimes the violence of the pain caufes cold clammy fweats and fainting.. The mind is generally much af- fedfed, and the fpirits are funk. The difeafe is often te¬ dious, efpecially if improperly treated, infomuch that the patient will continue in this miferable ftate for twenty or thirty days fucceffively ; nay, inftances have been known of its continuing for fix months. In this cafe the pains at laft become almoft intolerable : the patient’s breath acquires a ftrong fetid fmell like excrement, from a re- . tention of the feces, and an abforption of the putrid ef¬ fluvia from them by the lafteals. At laft, when the pain in the bowels begins to abate, a pain comes on in the fhoulder-joints and adjoining mufcles, with an unufual fenfation and tingling along the fpinal marrow. This foon extends itfelf from thence to the nerves of the arms and legs, which become weak ; and that weaknefs in- creafes till the extreme parts become paralytic, with a total lofs of motion, though a benumbed fenfation often remains. Sometimes, by a fudden metaftafis, the brain, becomes affedled, a ftupor and delirium come on, and the nervous fyftem is irritated to fuch a degree as to pro¬ duce general convulfions, which are frequently followed by death. At other times,, the periftaltic motion of the inteftines is inverted, and a true iliac paffion is produced, which alfo proves fatal in a fliort time; Sometimes the paralytic affedlion of the extremities goes off, and the pain of the bowels returns with its former violence ; and, on the ceflation of the pain in the inteftines, the extre¬ mities again become paralytic ; and thus the pain and palfy will alternate for a very long time.” The cure of this dreadful diforder is to be effedfed by removing the fpafmodic conftridfion ofthe inteftinal canal. In this form of colic there appears to be little difpofition to inflammatory adtion ; and therefore, wherever colic can be decidedly traced to the operation of lead, we fliould adminifter a large dofe of opium, and repeat it at fliort intervals, until the pain. (and of courfe the fpafmo¬ dic ftridture) is relieved. When thiseffedl has been pro¬ duced, we may proceed to excite the adlion of the bowels, and procure proper evacuations of feces ; after which, the cure is foon completed by tonics and cordials. This rndlice of firft: relieving the pain and conftridlion by piates,, before the bowels are attempted to be forced by purgative medicines, was llrongly recommended by Dr. Warren, (Med. Tranfadl. vol. ii.) and was alfo employed by Dr. Darwin, (Zoonotnia, vol. ii.) As affifting the antifpafmodic operation of opiates, the warm-bath, fo¬ mentations, &c. Ihould likewife be reforted to. Of the palfy which fucceeds to Colica pibfonum there feems to be a tendency in the conftitution, efpecially in recent cafes, to recover itfelf, if the exciting caufe is i avoided 5 PATHOLOGY. avoided ; and this may be aided by the local ftimulus of warm water, friction, &'c. and by mechanical fupport to the paralyzed hands. Dr. Pemberton has recommended that, for this latter purpofe, the patient Ihould have his hands and fingers extended upon a fort of battledore, tied to the fore-arm, which fhould be worn daily. He affirms that, in feveral inftances, a perfeft cure of the paralyfis from lead has been effeCled in the courfe of a few weeks. (Treatife on Dif. of the abdominal Vifcera.) Some varieties are mentioned as arifing from other caufes than the poifon of lead ; but it does not feem that this peculiar form of colic called rachialgia, and attended with paralyfis, is produced by any other materia. It has indeed been fuppofed, from its prevalence in cider-coun¬ tries, that acid ingefta might produce it ; but this oc¬ currence feems to have arifen from the frequent employ¬ ment of lend in the machinery of cider-making. The reader will find this opinion very clearly proved by con- fulting fir George Baker’s papers in the Medical Tranf. vol. iii. Dr. Hunter, ibid. Dr. Fothergill, Med. Obf. and Enq. vol..v. Indeed the pain arifing from acid ifigefta is generally with tene firms and relaxation rather than with conftipation. Alum has been ftrongly recommended in rachialgia. The modus operandi of this drug feems obfcure ; but it deferves mentioning from the refpeftability of tliofe who introduced it. The fame thing may be laid of the Cupri Sulphas. Salivation, percuffion, eleClricity, See. may all be ufed with benefit in this kind of palfy ; but they will feldom be fuccefsful if, as is generally the cafe, the attack of colic fhall have left behind hindrance of the gaftric and inteftinal funClions. It is in cafes when the latter cir- cumftance happens that the Bath water is a ufeful remedy. It is obvious that the return of Colica pi&onutn, and of the palfy which fucceeds it, can only be effectu¬ ally prevented by relinquiffiing thofe avocations which neceffarily expofe the patient to the influence of the poifonous metal which excites the difeafe ; or by re¬ fraining from thofe liquors with which any of its pre¬ parations are intermixed. When the buiinefs of the patient precludes this, much good may be derived from purgatives whenever conftipation has continued for a whole day. When colics arife from acrid poifonous matter taken into the ftomach, the only cure is either to evacuate the poifon itfelf by vomiting, or to fwallow fome other fub- ftance which may decompound it, and thus render it in¬ active. The moll common and dangerous fubftances of this kind are cprrofive mercury and arfenic. The former is eafily decompounded by alkaline falts ; the latter by ruagnefia in large quantities. Some kinds of fungi, when fwallowed, are apt to produce colics attended with flupor, delirium, and convullions ; and the fame fometimes hap¬ pens from eating a fhell-fifh known by the name of muf- cles. The effeCi of the latter is removed by vomiting. See the article Poison. 3. Colica crapulofa, (C. accidentalis, C. meconialis, Cull.) Colic from indigeftion,. The pain accompanied ivith naufea, head-ache, and dizzinefs, before vomiting, and often terminating in a griping loolenels. It is pro¬ duced by eating indigeftible aliments, or digeftible ali¬ ments in too great abundance. In this fpecies the vo¬ miting or loolenefs, or both together, frequently operate a cure When they do not, we may, following the natu¬ ral indications, excite ficknefs and purging. 4. Colica flatuienta, wind-colic. In this fpecies, the pain is acute, extending to the pit of the ftomach, often impeding refpiration ; accompanied with great fulnefs and flatulency; and relieved by preffure, bending the body forward, or expulfion of wind. The diforder is produced by crude and flatulent fruits, and hence com¬ mon among children. It is, however, more generally a fymptom of dyfpepfia, and hence- the cure is obvious. The paroxyfm is to he relieved by antifpafmodics and opium ; the cauffis removed if poffible, and the bowels kept open. Vol. XIX. No. 1294. 151 A fimilar treatment is requifite in the next fpecies, with this reftriCHon, however, that it is lb often conneded with general difturbnnce of the nervous and vafcular fyftems, that opium Ihould be lefs freely given, and fup- purations and clyfters ufed in preference to irritating purges. 5. Colica ftipata is characterized by fevere pain, obfti- nate coltivenefs, great tenfion, with little flatulency : the vomiting is fometimes accompanied with faeces 5 the cof- tivenefs, with bloody (trainings: it terminates, where not fatal, in a free dejeftion of theinfarfted matter. Dr. Good gives three varieties. cc. A vifeido meconio, from vifeid meconium. Colica me¬ conialis, Sanv. Cull. £. A facibus indurulh, from indurated fteces. C. fterco- rea, Cull. y. Ab enterolilho, from inteftinal concretions. C. cal- culofa, Cull. Ileus calculofus, Snuv. — The early volumes of the Phil.Tranf. contain fome very extraordinary cafes of this kind. The moil Angular is in No. 3. p. 68. anno t6Si. continued in No. 181. p. 94. anno 1686. by Dr. Konig, of Bern. The patient, Margaret Lower, a young woman of twenty-five, difeharged continually the con¬ tents of the inteftines, and even the clyfters that were injefted, by the mouth, and at length a number of (tones as hard as flint, fome in fragments, fome of the fize of peafe, others of that of filberts. A clafliing of Hones againft each other was felt by preffing the hand upon the abdomen : there was great conftipation, fevere gripings, dyfury ; and the urine, when voided, was often loaded with a gravelly matter. The aliment and injec¬ tions being conftantly returned by the mouth, Dr. Konig defifted /'or four months from offering her either meat, drink, or medicine of any kind, excepting occafionally a fpoon- ful of oil of almonds. Blood was nowand then vomited from the violence of the fpafmodic aClion of the ftomach ; and frequently urine, to the amount of three or four ounces at a time, of a ftrong tafte and fmell. The dif¬ eafe feems to have lafted, with remiffions, from January 1678 to February 1683, at which period the hiftoryis ab¬ ruptly dropped, though the patient feems to have been in a ftate of recovery. It was preceded by the appear¬ ance of veficular eruptions in the lkin, and was probably produced by their repullion. The chemical examination of the calculi is loofe and unfatisfaClory. 6. Colica callofa. This fpecies of colic differs mate¬ rially from all the preceding; for here th» contraction of the mufcular fibres is limited to a fmali portion of the in- teftine; and, analogous to what we obferve in the ure¬ thra and other membranous canals, the repetition of this aClion often ends in a certain permanent!}' -contracted ftate of the part affeCted. In the early Itages, however, this feems merely a diminifhed fphere of contraction ac¬ quired by the fibres in queftion ; for they are (till capable of dilatation, and no thickening of fubftance is at firft perceptible. This ftate cannot however continue long; the ftriCture becomes thickened, and fomewhat indurated, and the paffage of faeces in a great degree interrupted. The fituation in which we meet with this ftriCture is more commonly about the termination of the colon, and at the projection of the facrum, than any other part of the inteftinal canal : and, when one ftriCture is difeovered in this fituation, there is often another a few inches lower in the gut. This does not, however, uniformly happen, a ftriCture-being often met with about the termi¬ nation of the colon, where there is none in the inteftine ; and the fame impediment has been found between three and four inches from the anus, where there has been none higher. But thefe contractions occur fo exclufively in moll cafes about the figmoid flexure of the colon, and near its termination in the reChim, that this part fhould he carefully examined in every cafe of obftruCtion. Although the above parts of the colon are the mod obnoxious to ftriChires, yet it is evident the complaint may take place in any part of it. “ I have once feen,”- lays Dr. Baillie, “o.ne of the vulvulte canniventes much R r longer 152 PATHOLOG Y. longer than ufual, and paffing round on the infide of the jejunum like a broad ring. The canal of the gut was ne- celfarily much narrowed at this ring ; but no mifchief had arifen from it. This malformation, however, might have laid the foundation for future mifchief; fome fub- llance too large to pafs might have refted on the ring, and produced inflammation, ulceration, and untimely death.” And, in a cafe publifhed by Dr. Combe, in the fourth volume of the Tranfaftions of the College of Phyficians of London, where there was an uncommon pulfation in the aorta, dilfeftion difcovered the lower part of the ilium, as far as the colon, contracted for the fpace of three feet, to the flze of a turkey-quill ; the aorta was in a per¬ fectly healthy ftate. The fymptonis indicating the prefence of ftrifture in the reCtum, as chiefly copied from the accurate work of Mr. W. White, are, habitual coftivenefs ; occaflonal un- eafinefs, arifing from a fenfe of fulnefs in the courfe of the tranfverle arch of the colon, but more efpecially to¬ wards the termination of its figmoid flexure, chiefly occa* fioned from wind meeting with fome obftruCtion down¬ wards. The patient is often fenfible of theaggravation of this fymptom from a variation in the quality or quantity of his food. Sometimes the fulnefs may be felt externally, in the courfe of the figmoid flexure of the colon. Al¬ though this fymptom frequently happens to be the firlt to arreft the patient’s attention, and continues fome time before any particular local inconvenience is experienced from the palling of the feces, yet this by no means inva¬ riably occurs. Befides the fenfe of fulnefs juft noticed, other fenfations are often excited in the courfe of the colon ; viz. acute pain, a fenfe of p re flu re when the feces accumulate above the It rift ure ; violent fpafmodic con¬ tractions in different parts of the inteftine, which ufually happen after the colon has been exerted by expelling the feces. Sometimes the patient feels as if tightly girded with a cord. It may be proper to notice, that thefe dif¬ ferent fenfations are in general aggravated, in proportion as the ftrifture is feated high up in the reftum. Sooner or later the patient experiences an uneafinefs on going to ftool, attended with difficulty in voiding the feces. As the diforder advances, thealvine excretions become gra¬ dually more fcanty, the feces are ejefted fometimes flat, at others of a triangular form. They are fmaller than natural ; and are often difcharged with a fquirt, fome¬ times accompanied by a l'udden and loud explofion of Wind. The fame phenomena are thus concifely defcribed by Dr. R. White in the fourth volume of the Memoirs of the London Medical Society. “ When a perfon fomewhat advanced in life is troubled with frequent conftipation, complains of fulnels and weight in thertomach, with re¬ peated inclination to difcharge the contents, and uneafy rumbling in the belly, and diftention in the lower part of it, with a fenfation of numbnefs toward the upper part of the facrum, extending down the reftum; repeated fruitlefs efforts being alfo made to pafs a ftool, attended with a fenfe of conltriftion and tenefinus high up in the reftum, and flatus, which feemed to the patient to oc¬ cupy the intermediate fpace, burfts forth; clyfters failing as well as medicines, and the complaint unattended with fever or pain ; — it will be reafonable to expeft fome me¬ chanical ©bftruftion in the paffage.” After an evacuation, a fenfation commonly continues for fome time, as if the w'hole of the feces had not been expelled. This by degrees goes off, and the patient feels himfelf tolerably eafy until the next time of going to ftool, when a fimilar fenfation recurs. With regard to the leffened diameter of the feces juft noticed, which mult neceffarily be the cafe whenever a permanently-contrafted ftate of the gut takes place, there are fome exceptions. If the ftrifture indeed fliould hap¬ pen to be fo low in the reftum as not to allow room for the accumulation of feces, it muft appear evident that they will be found uniform in diameter, in proportion to the degree of ftrifture, while they continue to be dif-' charged in a figured ftate. And alfo, when the ftrifture is high up in the reftum, fo long as the gut below re¬ tains its natural expulfive power, an accumulation will be prevented, and the diminifhed fize of the feces will con¬ tinue. But, as the diforder increafes, the inferior por¬ tion of the inteftine gradually lofes that power;' and, when the contraftion becomes confiderable, a fmall quan¬ tity of feces only paffes at a time through the ftrifture, and, not being fufficient to ftimulate the lower part of the reftum, (which in a great rneafure is deprived of its natural aftion,) an accumulation goes on from time to time, until at length it becomes difficult to remove ; and, on thofe occalions, feces of a natural fize have been fometimes difcharged. Pain of the back, about the facrum, is a very common attendant on ftrifture in the reftum, and fometimes a primary lymptom; the pain frequently (hooting down the thighs, and in fotne inftances to the foies of the feet. Haemorrhage is alfo a frequent occurrence, as well as a mucous difcharge. Mr. White alfo has found pain in the back part of the head a ufual lymptom of this difeafe. When the foregoing fymptoms lead us to fufpeft the prefence of ftrifture, manual examination inuft be had recourl'e to. Indeed the matter can only be determined by this method. “This ought to be performed in the nioft careful and attentive manner, feeing there is a pof- fibiliry of miftaking the complaint either for a difeafed proftate gland, or fora fcirrhous uterus, efpecially if the hardnefs is attached to the cervix uteri, or back part of the v3gina. In profecuting the examination, the firlt ftepto be taken (after the bowels have been emptied) is to introduce the finger (oiled) as high up the reftum as poffible, at the fame time defiring the patient to bear' down, as if going to ftool. For, if the examination is firft made by introducing a bougie, it may happen that the inftrument is pu(hed between the folds of the intef¬ tine, particularly if there (hould be particular laxity of its internal membrane; and the practitioner may be led to fuppofe there is a ftrifture, when in reality none ex- ifts. If, however, on introducing the finger, neither ftrifture nor induration can be difcovered in the reftum, a bougie, ten or twelve inches in length and pretty thick, muft be introduced, and paffed as high as the termination of the colon; which will ealily be done, if ftrifture is not likewife prefent at the lower part of the reftum. This complaint is liable to be confounded with diar¬ rhoea, dyfentery, piles, indeed with almoft every chronic cli(eafe of the inteftines, and, above all, with fcirrhus uteri, and fcirrhus of the reftum. So much difficulty, indeed, occurs in refpeft to the former, that Dr. White fays, “ Symptoms of the contracted reftum in the female are fo fimilar to that of a lcirrhous uterus, that I do not know any mark whereby the one difeafe can be diftin- guiftied from the other, excepting that in the latter the urinary biadder is more liable to be atfefted than in the former; though fometimes pain and difficulty in difcharg- ing the urine attend that alfo.” In diftinguilhing this cafe from Proftica callofa, or fcirrhus of the reftum, we fliould notice, that, in Am¬ ple ftrifture, pain is only experienced on going to ftool ; while, in a fcirrhous ftate of the reftum, the fufferings are not only greater at thefe times, but there is alfo, at other times, great pain about the facrum, often (hooting down the thighs, as well as a fenle of burning heat and pain in the reftum. In this laft deplorable difeafe, efpe¬ cially in its advanced ftages, the feces palled are gene¬ rally in a liquid ftate, fo that the difeafe may be con¬ founded with a chronic dyfenteric complaint. In ftric- tures of the reftum, there is little emaciation or lofs of' ftrength until the diforder is far advanced; the counte¬ nance then becomes fallow; and, in fome inftances, the pulfe is quick, with other heftic fymptoms. Moreover, as we before remarked, the Ample ftrifture is higher up than 153 PATHOLOGY. than the fcirrhus, and not generally of fo hard and un¬ yielding a ftruCture. The cleared: diagnofis is derived, however, from the introduction of a canula, as recom¬ mended by Mr. Coley of Bridgnorth, in a paper read to the Medico-Chirurgical Society. This gentleman having a patient under his care, whom he was unable to afford relief to by a common bougie, fince that inftrument invariably bent upon itfelf, had recourfe to a tin canula, for the purpofe of giving fupport to the yielding bougie. The experiment fucceeded ; and, having occalion fome time after to increafe the diameter of his canula, Mr. Coley found that, by holding a lighted candle at the end of it, he could readily diftinguifh the contracted part of the inteftine. In the treatment of this affeCtion, the principal part conlifts in removing the caufes of irritation by diet of the lead irritating kind, as jellies, fago, &c. and evacua¬ ting the bowels daily by clyders of warm u’ater. When injections cannot be thrown up in the ordinary way, from the contracted date of the pafl'age, a large hollow bougie may be fadened (indead of a common pipe) to a bladder, by which means they may be conveyed beyond the obltruCtion. Nervous irritation may belefl’ened byconium, hyofcia- raus, &c. and the combination of the blue pill with them is generally required to promote the biliary difcharge, which is of courfemuch deranged in cafes of long ftand- ing. If purgatives are given by the mouth, none of this clafs fhould luperfede cador oil. It is fcarcely neceflary to add, that aloetic cathartics tend to increafe the complaint. In refpeCI to the regulation of the alvine excretions it is proper to remark, that attention to this part is not only neceflary in the camdipated date of the bowels, attendant on the early dage of the difeafe, but alfo in its more ad¬ vanced progrefs, when diarrhoea has fupervened, becaufe the evacuations are feldorn in fuflicient quantity to re¬ lieve the bowels, without the aid of laxatives. The local application of the bougie is the next thing to be confidered. This will often produce much irrita¬ tion and aggravation, unlefs nervous excitement be re¬ moved by emptying the bowels and regulating the diet previous to its ufe. Before employing this indrument, we diould be well allured that fcirrhus is not prefent, as it uniformly aggravates that difeafe. The bougie fhould be, at fil'd, of fuch a fize as to pafs the driCture without conliderable refidance, led irritation and inflammation be excited. The fize diould alfo be increafed very gra¬ dually till the parts become accudoined to the flimulus. There being always more or lefs of fpafmodic aCtion ex¬ cited by the bougie, it fhould be introduced flowly and gently, waiting a little when it touches the driCture, be¬ fore it is puflied through. At fird it diould not remain longer than half an hour in the reCtum ; if there be much irritation, not fo long. By degrees it may be al¬ lowed to remain eight or ten hours at a time, with little or no inconvenience to the patient. In general, it may be pafied daily. From four or five to eight or ten weeks will elapfe before the flriflure admits a full-fized bougie; even then, the indrument mud be gradually left ofl’. It is found that the natural aCfion of the bow'els is gene¬ rally much improved by the application of the bougie. As auxiliaries we may mention the hip-bath, and injec¬ tions with extraCt of poppy. The former may be ufed for a few minutes before employing the bougie ; and the anodyne injection after the bougie contributes to leflen the morbid irritability of the part. With refpeCI to the kind of bougie, we fhould prefer that ufed by Mr. Coley, though perhaps, this is not a matter of the fird importance. Mr. Coley’s bougies are compofed of lint rolled up, tied •at the lower end with dring, which forms a loop about three inches long, for the purpofe of being fecured to a T bandage. They are to be immerfed in a compofition of lead four parts, and wax one part; and then drawn through a wooden frame, having holes of various diame¬ ters. Great advantage, our author obferves, will be de¬ rived from making the points conical. His manner of applying them difl’ers from the common mode in this, that they are wholly concealed within the re€tum, as will be prefentiy deicribed ; which he confiders a great improve¬ ment, as it enables the patient to walk about, or even ride on horfeback, during the ufe of them. He advifes them to remain in the bowel, if poflible, all night ; which, he thinks, has the efteCt of promoting the abforption of difeafed ftruCture, by long-continued preflure, as well as of refilling the tendency to contraft. At the fame time, he obferves, that the difcharge of the cerate, produced by the heat and moidure of the anus, is avoided; the cerate not being melted by any portion of the inteftine above the J'phinSter. Mr. White mentions a variety of this difeafe, which arifes in confequence of venereal infeCtion. “When the diforder proceeds fronrthis caufe, it generally commences with an appearance either of ulceration, or excrefcence about the verge of the anus. The fphinCter ani becomes gradually contracted ; and, the difeafe extending up¬ wards within the reCtum, a conliderable tlrickening and induration of the coats of the intefline take place, which produce great irregularity and contraction in the pafl'age. Sometimes there is a continued line of contraction from the anus, as far as the finger can reach, then terminating in a kind of cartilaginous border, the inner membrane having a thickened and condenfed feel. There is often a difcharge indicating a difeafed, if not ulcerated, flute of the inner membrane above the contracted portion of inteftine. All the cafes which I have hitherto met with of this nature, have occurred in females, and they have uniformly proved incurable, when attended with the ftruClural derangement juft deferibed.” The reCtum is alfo liable to contraction from tubercles fituated immediately above the fphinCter ani, very differ¬ ent from the foft bluilh hasmorrhoidal tubercles which often furround the anus. Thefe lafl protrude when the patient (trains ; and, when returned within the fphinCter, no hardnefs can be perceived in the gut. It isthereverfe with the other tubercles; they do not come below the fphinCter, and they have an indurated feel. The fpecies of contraction noticed as the confequence of venereal infection, Mr. W. has found exafperated by the bougie, even when conjoined with a regular courfe of mercury. “ In the tuberculated ftate, however, ari- fing from afimilar caufe, (he fays,) the bougie will be found of great fervice.” In fcirrhus of the reCtum, the bou¬ gie would manifeftly be improper. Sometimes ftriCture is attended by prolapfus ani, flefhy excrefcences, or luemorrhoidal tubercles, udiich prove a hindrance to the ufe of the bougie, and require to be previoufly removed by ligature or the knife. But, in doing this, he muff be careful not to include any portion of the prolapfed inteftine, which fometimes comes down with the excrefcence. The prolapfus ani, however, which occurs as the confequence of ftriCture in the rec¬ tum, is very partial, and unlike the common prolapfus. Whilft the whole of the lower portion of the reCtum pro¬ trudes from a relaxation of the fphinCter, this only occu¬ pies one fide of the anus, forming a pendulous flap. It is neceflary to puftithis flap gently up with the fingerbeyond the fphinCter, to make way for the bougie to pafs, which otherwife would be apt to get entangled in the prolapfed portion of tire inteftine. The ufe of the bougie will fometimes overcome this impediment ; but, if it fhould continue after the pafl’age is dilated, and prove trouble- fome, the pendulous part may be removed with the knife, and the patient freed from future inconvenience. With regard to the divifion of the ftriCture, as prac¬ ticed by Wifeman and others, there can be no doubt of the expediency of the operation in fome inftances, where the bougie fails, and the ftriCture is of a cartilaginous hardnefs. See the article Surgery. Genua 154 PATHOLOGY. GemisVII. Coprof afis, [from xoWgftC, dung, and oretait;, ftagnation.] Retention of the Faeces. This genus has only two fpecies. 1. Coprodnfis coafta, (Obftipatio, Cull) Coftivenefs. This is a complaint to which fedentary perfons and bon- vivants are much expofed, and which has long and juftly been considered a frequent caufe of the numerous dy ft¬ p-optic cafes we daily witnefs. Its obvious cure is the ufe of cathartics ; and for thefe medicines formulae abound in every family. The frequent recourfe which is had to purgatives tends, however, to impair the functions of the intellines, by rendering the peri ftal tic powers inaflive except under the influence of ftimulus; and further, even this ftimulus, as is well known, gradually lofes its effedt by repetition. On this account our therapeutical indications fliould embrace a wider field of remedial agency. As the mufcular fibres are the agents of the pe- mftaltic motioit, we Should endeavour to Strengthen the tone of the mufcular iYltem generally, fince one part is feldom weak without all participating in the fame debi¬ lity. This purpofe is peculiarly to be effedled by exer- cife to fuch a degree as to Strengthen mufcular contraction without producing fatigue; by the cold bath, and by medicines which are laid to give tone to the mufcles. Mr. Howfhip, in his work on the inteftines, fays, that bark internally administered for l'ome continuance will bring on the healthy aCtion of the trowels to fuch a degree that purgatives become unnecelTary. The belt method of ufiog it feems to be to unite it with a moderate dofe of cathartic medicine, and then gradually diminifli the dofe of the latter, and increafe that of the former. If coftivenefs continues, however, a clyfter of warm water will produce the al vine difeharge, and without, of ciourfe, Stimulating in any inordinate degree the entire Secretion, fince this meafure does nothing more than dift folve the faeces. The life of clyfters is becoming more fashionable in this country, and there is every reafon to believe, that, if we ufed them oftener, and applied draft tic purges lefs frequently, the digeltive apparatus of molt perlons would be found in a better condition. It has been recommended by foir.e lo endeavour to inllitute re¬ gular ftools by voluntary endeavours at regular periods ; but we believe this will feldom do good, except when an indolent habit of neglecting the calls of nature has been the caufe of the complaint; and, even then, draining Should not be long perfifled in. Codivenefs feldom occurs in young infants. When it does, it always arifes from badnefs or deficiency of the juirie*s milk, or from the food. If one copious evacu¬ ation take place every twenty-four hours, and the in¬ fant be thriving, there is no occafion for interference ; but, if there be any greater torpor of the bowels than this, fuitable remedies are to be employed. For this pur¬ pose, a brifk laxative may be given every day, for four or five times fucceflively. The bed laxatives for infants are manna, calcined magnefia, and cold drawn cador-oil. Where thefe means fail, and there is reafon to attribute the coftivenefs to the nurfe’s milk, we mud regulate the diet, and open freely the how-els, of the latter. Rut, if it be found that the milk dill pod’eO'es that injurious quality, the nurfe diould, if poflible, be changed. Where this cannot be done, four or five drops ol antimonial wine may be given to the infant every night at bed-time. 2. Coprodafis addricla. In this fpecies the fame ge¬ neral treatment fliould be regarded. Purgatives of a gentle kind, and gradually leflened as they are found ef¬ fectual, are the fird agents. Diet fliould be ufed of a re¬ laxing kipd, we mean fuch a# is principally compofed of green vegetables. The fympathy which exids between the (kin, the mucous lining on one part of the alimentary canai and another, render medicines applied to the Sto¬ mach and (kin of efteCt on the bowels ; fo the warm bath, naufeating doles of calomel and antimony, will, if perfevered in, fometimes effect a cure. Constipation often occurs without producing much inconvenience. Some perfons are accudomed to have their bowels moved not oftener than twice a- week ; and, to fuch, a week’s codivenefs is attended with no particular inconvenience. Chaptal mentions the cafe of a female patient, who, for four months, had no difeharge either from the bowels or kidneys, and as little evacuation by fweat, notwithdand- ing that her diet was confined to milk-whey and broths. And the writer of this article is acquainted with a lady who often pades a week or a fortnight, and on one occa¬ fion pafled a month, without a faecal evacuation : her urinary difeharge is copious, but clear ; and no extraor¬ dinary degree of perfpiration is manifed on her (kin. But this is nothing to cafes related in old books, as in the early volumes of the Phil. Tranf. and of the Journal des Scavans : from thefe and fuch like authorities, Dr. Mafon Good has quoted cafes of fasces retained for fix months — two years — three years — feven years ! Credut J a dans (ipellu ! Genus VIII. JDyfenteria, [from bad, and ttTcgor, bowel.] Dyfentery. Griping and tenefmus ; frequent mucous and bloody digedions, the fasces feldom dis¬ charged, and in (mall quantities. Bloody flux. The word chfenteiy, as ufed by the ancients, had no very precife fignification. Originally its import was “ an aft’e&ion of the* bojvels” in general; and we find Hippo¬ crates ufing it, not only to Signify all ulcerations, but all haemorrhages, of the intedines (even thofe which are critical and falutary), and likewise every kind of dux, with or without blood. (Prorrh. 2. et Epidem. lib. ii.) It would feem, however, that, after his time, foir.e of the other Greek authors, whofe works are Jod, were fenfible of this want of precifion, and therefore redrifted the meaning of the word to an ulceration of the bowels, at¬ tended with gripes and tenefmus, (or draining,) and with imicousand bloody (tools. For a dileafe with thefe fymp- toms CelSus calls tormina, and fays it is the dyfcntcria of the Greeks ; and Ccelius Aurelianus, retaining theGreek name, deferibes the dyfentery much in the lame manner with Celfus. (See Celf. de Med. lib. iv. cap. xv. Cod. Aurel. de Morb. Chron. lib. iv. cap. vi.) Yet Galen re¬ turns to the looler acceptation of the word, fometimes defining a dyfentery “an ulceration of the bowels,” at other times mentioning four fpecies of that didemper, all with bloody dools ; but of which only one agrees with the tormina of Celfus, or the dylentery of the moderns. Are- tseus confines the term to an ulceration of the bowels ; and this notion of theconflaiit ulceration of the bowels, in conjunction with dyfenteric fymptoms, prevailed in all medical writings until the time of Sydenham and Willis. Dr. Good mentions two fpecies of this difeafe : 1. Dyfenteriu (implex; unaccompanied with fever: the faeces, when difeharged, evacuated without confiderable pain, of a natural quality, and adording eafe. 2. Dyfenteria pyreCtica, accompanied with fever, great lofs of Strength, and deprefiion of fpirits : the faeces, when discharged, of various colours and confidence; highly fetid, and mixed with putrid fanies, Sebaceous matter, or membranous films. Of the fird Species of dyfentery it is unnecedary to fay much ; its cure is effected by milder means than the fecond, though according to the fame indica¬ tions. Nor, important and dire as the fecond form is, will it require a long difeudion, fince its nature has been fo clolely dudied, and its method of cure (o well efta- blifhed of late by our colonial furgeons, that we have the fatisfaCtion of prefen ting more general principles as guides on this fubjeCt than we are enabled to do with regard to mod other difeafes. In (peculating on the nature of dyfentery, the fird thing that requires our condderation is the increafed difeharge from the bowels. Of the caufe of this pheno¬ menon one explanation alone pe may perhaps prevent. To trace therefore, by dilfeCfion of morbid parts, the various appearances which different grades of diforganization prefent, and to combine this information with clofe and faithful delineations of ac¬ companying external fymptoms, are purfuits which, though we nnift confefs hitherto almoft ufelefs in regard to the complaints in queftion, muft ultimately meet their reward. Attempts of this nature have been made, and are ftill profecuted with much ardour, particularly on the continent. The knowledge at prefent obtained is however fmall and unfatisfaftory ; fo much fo indeed, that many of the varieties arifing out of the feven fpecies of our author we fhall pafs over w ithout comment, merely referring our readers to fome of the numerous hiftories which the learned Dr. Good has noticed ; and to the article Tumours for an account of the probable ori¬ gin and mode of growth obfervable in diforganization in general. 1. Parabyfma hepaticum : hard tumour in the right bypochondrium, verging towards, and fometimes appear¬ ing at, the pit of the ftomach ; general languor ; pale or yellow countenance ; dyfpepfy ; dejections irregular, often whitifh. There are four varieties of this fpecies. a. P. coaCtum; from infarction. Found in feeble children, who fecrete lefs bile, and have the cells of the liver clogged with mucus from atony of the abforbents. Found alfo in intemperate livers ; and in foreigners who refide in hot climates: an unequal atony, and at times paralyfis, being produced in the organ from the exceffive ftimulus antecedently excited by the rays of the fun or the ufe of fpirituous potations. (See Hepatitis in this ar¬ ticle.) In this cafe, gentle dofes of calomel, or blue pill, ftriCt regulation of the bowels, abftemious regimen, &c. are generally followed, after due perfeverance, by reftoration to health. The fame remarks are applicable to the treatment of the infarCted fpleen ; for by thefe means a fpleen fo\enlarged as to occupy the major part of the abdomen has been effectually removed in a few months. |3. P. fcirrhofum ; the tumour affuming a fcirrhous character. 7. P. cololithicum; accompanied with bilious concre¬ tions. (51. P. helminthicum ; accompanied with flukes, hyda¬ tids, or other worms. See Winker’s Difp. de Hydat. apud Bonet, Med. Septentr. ii. Darwin, vol. iii. Other morbid ftruftures of various forts and fizes are occafionally built up in the liver; but, as there is little evidence of their feparate origin, it is needlefs to multi¬ ply the varieties. They are fo thickly interfperfed in our periodical journals, that all reference feems unnecef- fary. Some varieties of them will be found in the fu- perb wmrk of Dr. Farr, (Morbid Anat. Liver, 1812.) 2. Parabyfma fplenicum; ague-cake: an indurated tumour below the falfe ribs on the left fide, and towards Z z the PATHOLOGY 176 the fpine on the lame fide; pale countenance; general debility. Three varieties are noted. a. P. coaflum ; from infar&ion. Chiefly after obfti- nate remittents or intermittents in organs weakened by previous intemperance ; the ablorbents being hence doubly debilitated. P. fcirrhofum ; affuming a feirrhous charafter. On the death of a woman it was found to weigh thirty-three pounds, and to fill nearly the whole of the abdomen. The complaint lafted feventeen years before the patient died, during nearly the whole of which Ihe purfued her itfual avocations. Sauvages. — Three times its natural fize. Buillie, Morb. Anat. Fafc. vi. pi. 3. — Contained fifteen pints of pus. FUJI. de l' Acad, des Sciences, 1753. — The entire vifcus has often been extirpated without in¬ jury. 7. P. cartilaginofum : the coats of the fpleen converted into a cartilaginous fubftance. Baillie, Morb. Anat. Fafc. vi. pi. 1. 3. Parabyfma pancreaticum : hard elongated tumour, running tranfverfely in the epigaftric region; dyfpepfy ; general languor. Here are two varieties. a. P. coa&um; from infarftion. Buillie, Morb. Anat. pi. vii. fig. 1. — Torpitude produced by the ftimulus of tobacco, almoft inceflantly chewed or fmoked for many years; fatal. Darwin. (3. P. calculofum ; accompanied with white calculous concretions. Buillie ut fup. fig. 2, 3, 4. The pancreas occafionally aflumes a feirrhous ftrudfture. It is delcribed as remarkable for the little general diftur- bance of the fyftem ; the fixed and burning pain at the pit of the flomach, exceflively increaled by the preflu re of the diftended flomach ; fo much fo indeed, that, though the appetite is often good, the patient is com¬ pelled to induce vomiting after eating, to lull the pain. The bent pofture, as taking oft' compreflion, is likewife preferred. Coflive ftate of the bowels much increales the pain, by producing the like preffure on the difeafed vi(- cera. The palliative treatment is therefore obvious. 4. Parabyfma melentericum : indurated and irregular mafs of tumours below the flomach, yielding to the pref- fure of the hand; pale bloated countenance ; atrophy; the appetite at the fame time feldom diminilhed, often voracious. There are fix varieties. а. P. lielminthicum ; accompanied with hydatids or worms. jS. P. ftrumofum ; accompanied with fcrophula. See Marafnius, in this article. y. P. fcirrhofum ; accompanied with feirrhus. б. P. fareomaticum ; accompanied with farcomatous excrefcences. e P. fleatomatofum ; accompanied with fteatomatous excrefcences. In one inftance, the tumour weighed 40 lbs. Nov. Act. Nut. Cur. vol. i. if. P. fungofum ; accompanied with fungous excref¬ cences. The above varieties are from Sauvages, who has been copied by Cullen. The tumours are often very large, and conglobated : and at times accompanied with cyfts filled with a limpid fluid. In one inftance thefe amounted to twenty of various fixes, one as large as a child’s head, fix as large as the fift, and the reft refem- bling hens’ and pigeons’ eggs. Hence the whole abdo¬ men is in fame cafes fo generally tumefied as to give a j'emblance of pregnancy. This is particularly the cafe with the laft variety; and as the appetite, ftate of the bowels and bladder, are often unaffected, there is not unfrequently feme difficulty in determining the nature of the difeafe. See Sauv. in loco ; as alfo the writings of Welfch, Trincavelli, Morgagni, and Rioiarii, who have made collections of extraordinary cafes ; and compare Cruikfhank on the Anatomy of the abforbing Veffels, p. j 1 5. 2d edit. 4to. 5. Parabyfma inteftinale: the tumour hard and circum- fcribed ; round or elongated ; moveable upon the pref¬ fure of both hands ; irregular deje&ions 5 obftinate vo¬ miting ; pyrexy ; and for the moll part emaciation. Two varieties. а. P. conglomeratum ; cohefive, and conglomerated. Morgagn. de Sed. et Cauf. Morb. tom. ii. In this cafe the tumour lay fenfible to fight, of a circular fhape between the enfiform appendix and navel. On diffeCtion, the ileum and adjoining portion of thejejunum were retrac¬ ted upwards, coacervated, and firmly adhefive. (9. P. farcomatofum. Fantoni. Obf. Med. feleCh ii. In this cafe the tumour, of an oblong fhape, lay below the left hypochondrium inclining to the epigaftrium, prominent, with unequal hardnefs. On diffeClion, every other part being found healthy, the colon, under the fto- mach, and towards the left fide, for the length of the palm of the hand, appeared clofely indurated, diftended, and loaded with a flefliy fibrous peculiarly- thickened tumour, which contracted its diameter. б. Parabyfma omentale; the tumour indurated and diffufed ; frequently fpreading over the whole of the ab¬ dominal region ; dyfpncea ; emaciation. This fpecies is ufually of a mixed kind : infarCled ; feirrhous; glandu¬ lar; and cartilaginous. It has been found of various extent and magnitude ; from a weight of five pounds to twenty, twenty-five, thirty, and in one inftance (Greg. Hurftii. Prob. 10. dec. vi.) fifty-fix pounds, occupying the whole capacity of the belly. In one cafe, the hard¬ nefs was almoft ftony -. Panarol. Pentec. iii. obf. 10. In another, offeous, the weight thirteen pounds: Mongin , Hilt, de 1’Acad. des Sciences, 1732. In a third, loaded with many thoufand glandules ; in a fourth, accompa¬ nied with excruciating pains, the weight fixteen pounds : lluxh. Phil. Tranf. vol. vii. 7. Parabyfma complicatum : the belly hard, elevated, and diftended as though pregnant, and often fuppofed to be fo; yet more or lefs knotty and unequal ; the breath¬ ing feldom impeded ; for the moft part, acute pain, nau- fea, obftinate vomiting, and third. (Phyfconia polyf- planchna. Sauv. Cull. Phyfconia vifeeraiis. Auc. Far.) The fymptoms of this fpecies, Dr. Good obferves, mull vary according to the organs affefted, and the nature and extent of the difeafe. The enlargement is generally found to be farcomatous, feirrhous, hydatidous, oradi- pofe. The liver is in moft cafes more or lefs concerned ; fometimes in connexion w-ith the fpleen, fometimes with the mefentery, fometimes with the ftomach orinteftines, and fometimes with all together. Hildanus found the liver fo enlarged as to pafs beyond the falfe ribs of the left fide, with the fpleen equally enlarged, and fixed to the hepatic lobe. Cent. ii. Obf. 43. — Huldenreich, in a woman of forty-five years of age, found the liver feirrhous, weighing fourteen pounds, with a flelhy excrefcence in the mefentery of the fize of a child’s head ; Mifcel. Nat. Cur. ann . vi. and vii. Jaundice accompanied this cafe. — Bartholine mentions a woman of elegant form, in the flower of her age, attacked with another va¬ riety of this difeafe, which at length deftroyed her : when all the inteftines, liver, fpleen, and every adjoining vif¬ cus, w'ere found intermixed, and buried in fat ; the liver being at the fame time enlarged and feirrhous, and filling both hypochondria ; the ftomach thickened, and cartila¬ ginous. Cent. ii. — Coiter found the whole of thefe organs adhering together, and filled with cyfts of different fizes diftended with a limpid fluid; he reckoned more than, fourfeore : the organs themfelves were exhaufted and dry. ObJ'. Anat. p. 117. See alfo the works of De Haen and Boerhaave for remarkable diffe&ions of the fame kind. Recent refearches feem to prove in a very convincing manner, that, however different the matter contained in abdominal tumours, they have a common origin in tu¬ bercles, or, as fome fay, in hydatids. We (hall not enter into this fpeculation now ; but, as it is of importance to diftinguifh the earlieft approaches of a diforder which gra¬ dually involves the whole of the liver, peritoneum, in- teftines3 PATHOLOGY. 177 tedines, and occafionally the domach, in one dreadful and incurable difeafe, we ftiall tranfcribe from Dr. Baron a clear, and we believe, from our own obfervation, faith¬ ful, portrait of its primary fymptoms. The complaint comes on in general with tendernefs and dillention of the abdomen, accompanied with nau- fea and vomiting. The bowels, for the mod part, are coftive, both before and after the attack ; but they are frequently in an oppofite date. At this period, the fymp¬ toms not being fo violent as to force the patient to feek for proper relief, they are very apt to be negleCted : but, unlefs the true nature of the diforder be difcovered, and its courfe arreded at an early dage, all fubfequent efforts will probably be ufelefs. The progrefs of the aft'eCtion is as follows: the bowels become more and more irregular in their aCtion ; the tendernefs and fwelling increafe ; the appetite fails; the puife acquires greater velocity; the features look fharp and contracted ; the countenance becomes pale or fallow, the lips parched and fkinny; the tongue fometimes of a bright colour, refembling what is feen in diabetes, at other times it is covered with a thick whitifh mucus. The flefli and drength decay rapidly : great emaciation takes place : the fkin, except towards the lad dage, is for the mod part dry and fealy : the urine fmall in quantity 5 occafionally clear, more fre¬ quently otherwife. If a cough has not exided from the beginning, it is very apt to occur about this time; but this is by no means to be confidered asadiagnodic fymp¬ tom; its exidence depending upon the fpreading of the difeafe to the pleura, and thoracic vifcera. The feet fometimes fwell towards the conclufion of the difeafe, or the fwelling is confined to one leg or thigh. At this period, if the examination of the abdomen be made with due care, it will be found to communicate to the touch the feeling occafioned by a folid tumour; the integuments and mufcles not rolling upon the contained parts as in a date of health. But in i'ome cafes, where the effufion is conjoined with the original and more im¬ portant difeafe, a ferife of flu&uation may be difcovered. Very frequently the patient complains of a didreffing feeling of a “ broiling heat” at the domach ; the dil- charge of a tough ropy phlegm from the mouth, con- ftant naufea, with violent retching and vomiting ; and, in two cafes, the matter brought lip during feveral days before death was dcrcoraceous. In the courfe of the complaint, the appetite is for the mod part very bad; but the defire for liquids is infatiable, even though a con- fcioulnefs exids that a large quantity cannot be fwal- lowed without occafioning very great didrefs. When a feeling of finking and emptinefs prevails, the patient eagerly thinks of many articles that might allay his un- ealinels, but the fight of them feldom fails to excite loathing and difgud. Should any fudenance be taken, it is either fpeedily returned by vomiting, or it eaufes indefcribable uneafinefs. The patient rolls about in all directions, in vain feeking for fome point where he may repofe. Every aCtion of the domach or intedines comes to be performed with great pain. The paflage of flatus up¬ wards or downwards, the movements which take place before the evacuation of the bowels, all give rife to fuf- feFing. At times the pain is fharp and tranfient ; at others it is heavy and obtufe ; but a fenfe of weight is feldom abfent ; and it is more felt after vomiting or pur¬ ging than before. One patient, (an infant,) in allufion to this fymptom, ufed to put his hand on the abdomen, and exclaim piteoufly, “ Oh ! fo heavy !” Another faid, that his bowels felt as if they were “ tied up in a napkin.” At another time he faid, “ they feemed to be in a mafs;” and at a third, he declared that, if he had “ a fhot at¬ tached to every convolution of his intedines, he could not fufl'er more than he did.” The above-mentioned author has not found medical treatment of much avail even in the earlied flages of the above complaint. The production of a continued date of naufea has feemed to him to he attended with fome advantage ; and Dr. Jennerhas communicated fome cafes which were cured by a long continuance of that uneafy fenfation. It is neceffary, moreover, to palliate the fymptoms by bleeding occafionally; to keep the bowels lax, and to relieve pain by narcotics. Mercury, which might -be fuppofed an agent of fome ufe in promoting ablorption, appears to aggravate rather than to amelio¬ rate the complaint. It is to be obferved, that a fome- what different praCtice will be reforted to by thofe who regard this difeafe in a different light from Dr. Baron ; this gentleman confidering it a difeafe of the abforbents,, while others confider the tubercles (the mod common, and earlied appearances on difleCtion) to be produced by effufed coagulating lymph, the confequence of inflamma¬ tion. Dr. B. oppofes this view of the cafe with much> ingenuity ; but, upon fumming up all the faCts known on this intereding fubjeft, and after tracing the different gradations of difeafed flrufture with much labour, we are forced to acknowledge our information very infuffi- cient, and our minds far from being made up on this: head. Class II. PNEUMATICA, [from Tmv^a, breath.] Diseases of the Respiratory Function. Order I. Phonica, [from (pavn , the voice.] Diforders aft'eCling the Vocal Avenues. This Order contains fix: Genera. > Genus I. Coryza, [Gr. nafal mucus.] Running at the nofe. Galen confines the term xopvga. to defluxion from the nodrils alone ; but Hippocrates, as we learn from Celfus, applied it equally to defluxions from the head, nodrils, fauces, and ched. The latter Greek phyficians redrained it to the fird, and diflinguifhed the two latter by the name of catadagmus (y.uzcta-Tci'yy.oq), which equally imports dijlillutio or defluxion. Among modern writers coryza is uled fynonymoufly with catarrh, and is confequently regarded as a febrile aft'eCtion. It may in¬ deed occur, and often does fo, in various fevers as a fymptom ; but the older nolologids are more correCt in giving it a place diflindl from fever, when dridtly genuine.. Defluxion from the nodrils may proceed from two very different fets of eaufes : increafed adiion of the fecer- nents, and diminiffied adiion of the abforbents. The fird or dimulatiiig fet may confid of dernutatories ; of the irritation of fympathy, as in crying; of infedlious effluvia in the atmofphere (fometimes, though feldom, limiting their adtion to the mucous membrane of the nof- trils, and hence approaching the nature of catarrh); and of the local dimulus of an ozana, or nafal ulcer. The adiion of the abforbents may be diminiffied by expofure tofevere cold ; by the debility of old age ; and by a long habit of dernutatories, which have a tendency, in pro¬ portion to their ufe, to render all the veflels of the nof- trils torpid ; although the abforbents, as in the cafes of age and cold, and indeed in all indances of debility, are fooner operated upon than the fecernents. Here, there¬ fore, the defluxion is produced, not from increafed fecre- tion, for the fecretion may even belefs than in . a date of health; but from the fecretion, whatever its quantity, not being carried, oft' by its ufual channel; and hence again that frequent and unlightly dripping from the nof- trils of perfons who addiCt thenifelves to large quantities, of fnuff. Of this genus we have two fpecies, with their varieties. 1. Coryza entonica: the defluxion pellucid, mucous,, or ropy, with a fenfe of irritation or infarction. This fpecies is divided into four varieties. a. Sternutatoria ; from dernutatories. (3. Lachrymofa ; from weeping or crying ; the lachry¬ mal fecretion being increafed by mental emotion. y. Catarrhalis, cold in the head ; from fudden cold oe change in the temperature of the atmofphere ; accompa¬ nied with a nafal voice and lofs of finell ; and excoria¬ tion of the mucous membrane of the nodrils. The ca¬ tarrhal; PAT Ii O L, O G Y. 178 tarrhal variety of Coryza is mod frequently met with in clamp weather ; and, as might be fuppofed, ofcenett at¬ tacks perfons of the mod delicate habits. In general the increased fecretion induced gradually unloads the mucous membrane, and the complaint goes off. It is frequently connected with irritation of the bronchial lining of the lungs, and is then cured by the fame meafures as the latter affe&ion. C. catarrhalis in infants is often however of a violent nature ; fo much fo" indeed, that we fhall give a more full account of it than of the preceding varieties. This coryza generally attacks infants at the bread ; it is charafferized by freezing, tumefaction of the nofe and eye-lids, and a fhining appearance of the flcin covering thofe parts ; con- lfant open date of the mouth-, a rather dry date of the lips and tongue ; the refpiration is accompanied by a na- Ihl wheezing. Sucking is impeded, though liquids put into the mouth are fwailowed with facility; the infant takes the nipple in his mouth, but be has hardly made tiiree or four fuftions when his refpiration appears to be obdruCled ; his face becomes of a violet colour; he precipitately abandons the nipple, utters fome cries, and is feized with a fit -of fevere coughing, which leaves him in a date of partial dupor. Thefe accidents difappear in a fhort time, but are renewed whenever he again attempts to fuck. This fird dage of the difeafe lads for four or five days, or thereabouts ; it is followed by a fecretion from the nafal cavities, the exidence and quantity of which, 3t lead in new-born children, it is notalways eafy to afcertain, becaule it either dries or falls into the pha¬ rynx when the infant lies horizontally on its back. The abfence of any appearance of malformation of the tongue or of the mouth, the facility of deglutition, the occur¬ rence of fits of coughing every time the infant attempts to fuck, joined with the particular fymptoms before men¬ tioned, fuch as a drilling appearance of the lkin of the nofe, with a tumefadfion of this part and of the lower -eye-lids, a nafal fniffling, the manner of refpiration by the mouth, clearly fhow inflammation of the mucous ■membrane of the nafal cavities. The infant fhould be kept warm ; and we fhould direft the attendants to fo- urrent its nodrils with a warm decoftion, and carefully remove the mucus colledled in them. The infant will generally be able to fuck as foon as the date ot the nafal cavities permit it to breathe with the mouth clofed. S. C. ozsenofa, [from o£n, dench.] An trlcer fituated in the nofe, difcirarging a fetid purulent matter, and fonretimes accompanied with caries of the bones. Some authors have dignified by the term, an ill-conditioned ul¬ cer of the antrum. The fird meaning is the original one. The difeafe is defcribed as coming on with a trifling tumefadfion and rednefs about the ala nafi, accom¬ panied with a difcharge of mucus, with which the nof- ctril becomes obdrudted. The m.atter gradually affumes the appearance of pus, is mod copious in the morning, and is fometimes attended with lneezing and a little bleeding. The ulceration occalionally extends round the ala nafi to the cheek, but feldom far from the nofe, the ala of which alfo it rarely dedroys. The ozasna is often connected with fcrophulous and venereal complaints. In the latter cafes, portions of the oda fpongiofa often come away. After the complete cure of all venereal ■complaints, an exfoliating dead piece of bone will often Iceep up fymptoms fimilar to thofe of the ozaena, until it is detached. Mr. Pearfon remarks, that the ozatna frequently occurs as a fymptom of the Cachexia fiphi- loidea. It may perforate the feptum nafi, defiroy the offa fpongiofa, and even the oda nafi. Such mifchief is now more frequently the effedl of the Cachexia fiphiloi- dea than of Lues venerea. The ozaena mud not be con¬ founded with abfcefles in the upper jaw-bone. The variety we are treating of has its origin, in com¬ mon cafes, from a violent degree of catarrhalis ; and therefore, when the former complaint is prefen t, it is ne- ceflary to reprefs it as fad as poffible, by local bleeding and counter-irritants, before this unpleafant and intf aff¬ able dage of the complaint be induced. When drums orfiphilis is the caufe of the difcharge, the general treat¬ ment of thofe affedlions mud be had recourfe to. Caufes which arife from the former of thefe complaints are the mod traftable. 2. Coryza atonica: defluxion limpid, and without acrimony, or fenfe of irritation. Three varieties. a. Algida ; from expofure to a keen, frody,air. (3. Senilis ; from old age. y. Superadla ; from long and immoderate ufe of drong aromatics, volatile alkali, or fn u ft. Genus II. Polypus, [from its refemblance to the worm of that name.] A flelhy elongated excrefcence, fhooting from one or more Oender roots in the cavity of the nol- trils, running in different dire&ions, and aftefling the fpoech. It has lately been the cudom to apply the term polypus to a variety of concretions and excref'cences arifing in different parts of the body, of very different origins and textures, as polypi of the heart, which are perhaps always grumous blood, or concrete. gluten ; polypi of the uterus and bladder, which are caruncles with a flender bafe or peduncle ; and polypi of the trachea, which are alfo concrete gluten, occalionally coughed up, fometimes folid and branching, fometimes tubular. Dr. Good, how¬ ever, has followed Celfus, and mod writers from his time to that of Heider, in redoring and limiting it to the flelhy and ramifying excrefcence of the nodrils; and he divides it into two fpecies. 1. Polypus pladicus, the foft polypus : foft, compref- fible, chiefly pale-red ; apparently originating from dif- tention or relaxation of the Schneiderian membrane. 2. Polypus coriaceus, the bard cartilaginous polypus : firm, cartilaginous, chiefly deep-red ; apparently origi¬ nating from, or connected with, a caries of the ethmoid bone. This complaint, being modly the fubjeft of manual operation, will be treated of under the article Surgery. Genus III. Rhoncus, [Greek.] Hoarfe fonorous breath¬ ing from dagnation of mucus in the vocal canal. There are two fpecies. 1. Rhoncus dertor, fnoring or fnorting : the found deep and loud ; produced in the larynx and fauces. 2. Rhoncus eerchnus, wheezing: the found den fe, and impeded ; produced below the larynx. We cannot help confidering both thefe fpecies as fymp- tomatic; though Dr. Good fays, “it requires only a flight knowledge of the habits and morbid adlions of the animal fyflem to difcover indances in which both forts are idiopathic.” But his inode of proving this affertion feems rather to favour our opinion than his own ; for he dates, that u many perfons have a thick or wheezy refpi¬ ration, produced by corpulency, or by changes of the atmofphere from hot to cold, or from dry to moid, with¬ out any other difeafed adedlion.” Of the remaining three genera of this order we fiiall merely give our author’s divifions, the fubjeft being am¬ ply treated of under the articles Deaf and Dumb, Stam¬ mering, Stuttering, &c. Genus IV. Aphonia, [from u, priv. and (puvn, voice.] Dumbnefs ; total inability of fpeech. (Mutitas, Cull. and Sauv.) This, we think, fhould have been the lad genus of the order-. It contains three fpecies. j. Aphonia elingium, duinbnefs from the want of a tongue. This fpecies is naturally divided into two va¬ rieties : a, congenita, where the deditution is coeval with the birth ; and 6, where the fame is produced by accident, punifhment, or difeafe. In either cafe we may naturally fuppofe this to be a radical and irremediable de¬ feat. Privarion of the tongue, however, is not always accompanied with dumbnefs ; fince we have numerous, and 5 PATHOLOGY. 179 and apparently well-authenticated inftances of the fpeech remaining p'erfeft after a total lofs of 'tongue and of uvula. We (hall cite two of the mod remarkable. The firil is of a woman who was a native of Monfaray, in the territory of Elvas, in Portugal. The cafe was attefted by Wilcox biffiop of Rochefter, then chaplain to the Engliflt faftory at Liffion, in a letter dated from that city, Sept. 3, 1707 ; and was laid before the Royal So¬ ciety in London. The following is an ext raft from the letter: “The Conde d’Ericeyra, a nobleman of letters, and curious in natural knowledge, brought from the frontiers of this country a woman without a tongue, who yet (peaks very well; (he is feventeen years of age, but in ftature exceeds not one of (even or eight. I was with her at the conde’s houfe, and made her pronounce every letterof the alphabet, which (he can do diftinftly. She hath not the lead bit of a tongue, nor any thing like it ; but the teeth on both (ides of her under-jaw turn very much inward, and almod meet. She finds the greateft want of a tongue in eating; for, as others when they eat move their meat about with their tongue, (lie is forced to ufe Jier finger. She pretends to didinguiih tades very well, b,u t I believe doth it imperfeftly. Her voice, though very diftinfl, is a little hollow, and like that of old peo¬ ple who have loft half their teeth.” The other cafe was that of a girl born in Portugal alfo, (in 1718,) without ,a tongue. M. de Juffieu, of the French Academy, faw her at Lilbon when (he was about fifteen years of age. He examined her very attentively. In the place of the tongue was a (mail flefliy fubftance, which he found was able to contraft and dilate itfelf, of courfe it had all the mufcles of the tongue. The places where the tongue (hould be, remained plump and full, as if the tongue had been in being. He examined after¬ wards how (he performed the feveral fundlions of the tongue. Firft as to fpeech : (he pronounced (everal words fo diftinftly, that, had he not known (he wanted the tongue, he could not difcover by her fpeech that (he wanted it. She, however, pronounced the letters C, F, G, L, N, K, S, T, X, Z, with more difficulty than the other confonants. When (he pronounces them, (he in¬ clines her head forward, drawing back the chin as it were to the larynx, in order to raife it in a line with her teeth. The fecond funftion of the tongue, the tafte, Are had as exquiiite as any body. She told M. de Juffieu, that (he found an agreeable tafte in thofe dry fweetmeats he had given her. Maftication (lie performed with difficulty : the above fleffiy fubftance was not long enough to ga¬ ther and keep the food under the teeth : (be was here obliged to ufe the maxilla inferior, which through habit flie could either approach or remove from under the fu- perior, as (lie wanted to bring the morfel (lie would grind under the upper jaw. She fometimes ufed her finger for the fame purpofe. Deglutition muft needs be difficult to her. The tongue naturally forms itfelf into a kind of a hollow, (bmewhat like a fpoon, by which means it ga¬ thers every atom in the mouth, and protrudes them into the pharynx; but here nature and ufe from her infancy have in fome meafure fupplied this want of a tongue. The mufcles attached to the above flefhy fubftance raife themfelves up, forming at the fame time a kind of rima, which, in fome fort afting the part of a tongue, protrudes the aliments into the pharynx, (he obferving to incline her head forward, which facilitates their defcent. Thofe, together with the labial mufcles, help her by their con- traftion to fpit out what is in her mouth. M. Roland, furgeon at Saumur, has a cafe pretty near¬ ly the fame. A boy, nine years old, loft his tongue by a mortification that enfued an ulcer he had after the fmall pox. There was this difference, the root of the boy’s tongue was bifurcated, and pretty apparent, whereas the root of the above girl’s was round and fmall. This boy alfo could fpeak, and perform the other functions of the tongue, like the girl. Vot,. XIX. No. 1396. 2. Aphonia atonica : fpeechleffnefs from atony of the vocal organs. Here alfo we have two varieties. a. Oblsefa ; from lefion of the nerves of the tongue; as in paralyfis. Q. Pathematica ; from hidden and overwhelming ter¬ ror or other violent paffion. Commonly temporary, fometimes permanent. 3. Aphonia furdorum. Dumbnefs from deafnefs, con¬ genital or produced during infancy. Genus V. Dyfphonia , [from bad, and (pavri, voice.] Sound of the voice imperfeft or depraved. This is the Aphonia of Cullen and Suuvages. There are three fpe- cies and many varieties. 1. Dyfphonia fufurrans : the voice weak, whifpering, and fcarcely audible. The varieties are — «. Oblaefa ; from lefion of the nerves of the larynx, p. Pathematica ; from fuddeiriand overwhelming ter¬ ror, or other violent emotiorf of the mind : occafionally permanent. y. Comprefforia ; from permanent compreffion of the trachea. Catarrhalis ; from neglefted catarrh, s. Enervis ; from fimple debility of the larynx without any obvious caufe. Dr. Good “ has at this time a cafe under his care produced in this manner, in which the pa¬ tient, about forty years old, and otherwife in good health, has never fpoken, except in a whifper, for the laft fix years.” 2. Dyfphonia puberum, change of voice. The voice diffonant and untrue to itfelf, irregularly alternating from harffi to (brill; confined to the age of puberty. This, we think, can hardly be considered as a difeafe. Sauvages and Cullen call it Paraphonia puberum. 3. Dyfphonia immodulata : the voice permanently de¬ praved or inharmonious. The varieties are — a. Rauca ; naturally or habitually hoarfe, hard), or rough. (3. Nafalis ; fent with a cracked and grating found through the noftrils. Produced by habit, a deflation, or nafal obftruftion. y. Clangens ; Ihrill and Squalling, j. Sibilans; with a whizzing or hiding found, s. Stertens; with a fnorting, fnoring, guttural, or fter- torous, found. Ufually from relaxation of the glottis or velum palati. Palatina ; hoarfe, obfcure, indiftinft; with a fiffure or otiier deleft in the palate. This defeft is moftly con¬ genital ; hut occafionally a Sequel of lues and fome other diforders. Genus VI. Pfellifmus, [Gr. to Hammer.] Articulation imperfeft or depraved. There are two Species. 1. Pfellifmus bambalia, ftammering. The flow of ' the articulation difturbed by irregular intermiffions or Snatches. Dr. Good makes two varieties. a. Hasfitans, or hefitation : involuntary and tremu¬ lous retardation in articulating particular Syllables. (3. Titubans, or fluttering: involuntary and tremu¬ lous reduplication of fome Syllables, alternating with a tremulous hurry of thofe that follow. Thefe two varieties of ftammering are thus well de¬ scribed by Shakefpeare : “ I would thou couldft Hammer, that thou mighteft pour out of thy mouth, as wine comes out of a narrow-mouthed bottle, either too much at once or none at all.” 2. Pfellifmus blsefitas. The enunciation vitious. Here we have no fewer than Seven varieties. a. Ringens ; with a vibration or redoubling of the letter R. Lallans ; the letter L unduly liquid, or fubftituted for R. As when delufive is pronounced dek'ufive, as though the l poflefled the power of the fpanifti ll, or the Italian gl ; or as when parable is pronounced pa/ab!e. 3 A Alcibiades i80 PATHOLOG Y. A'lcibiades is fuppofed to have laboured under this de¬ feat. It is alfo laid to be common to the Jews of China, who have dwelt among the Chinefe fo long as to have loft; the found of R, in confequence of its not exifting in the Chinefe tongue. y. Emolliens; the harfh letters exchanged for foft, as in the fubftitution of ansel for angel ; capidol for capital ; eh t for that. Balbutiens ; labials, as B, M, P, too frequently in¬ troduced, or ufed inftead of other letters. So Feda is pronounced Beda, Fenares Benares, in Bengal, the Ben¬ galee having no V. Soimpringeisoften ufed for in/ringe; i&ory for itiory ; though b and not v is here the radical letter, the Latin term being efmr. £. Mogilalia; labials omitted or exchanged for other letters. Moll commonly P for F, and F for V, as./ilfer for pilfer; tiifh for/dfh. So the Latin fiiilo is transformed by the French into filler. Dentiloquens, lifping : dentals, as C, S, T, Z, too frequently employed; producing the effeft of what is called, in common language, fpeaking through the teeth. v>. Gutturalis; imperfect utterance of the guttural let¬ ters; as G, J, H, X. This, and indeed all the varieties of the prefent fpecies, as well as many others that are connected with it, are moft ufually the refult of vicious habit, produced by want of attention to the articulation of founds in infancy, or to affectation. They are alfo fbmetimes dependant upon a mifconftruCtion of the vocal organs : of which the prefent variety furnillies us with an example; for a defective utterance of the guttural letters mull be a neceflary confequence of a fifl'ure in the palate. Order II. Pneumonica, [Gr. from breath.] Dif- orders affecting the Lungs, their membranes, or mo¬ tive power; and producing irregular, impeded, or pain¬ ful, refpiration. The refpiratory fyftem performs the talk of prefenting to the blood a certain aerial matter neceflary to that fluid ere it can perform many of the moll important functions of the animal economy. The powers in ufe are, i. Large fponge-like mafles called lungs, which paf- fiveiy receive and emit, and which in the remoteft termi¬ nation of their cells allow contadt (or nearly fo) between the blood and the atmofphere. 2. Moving powers, or mufcles of refpiration, which, alternately prefling or re¬ moving prefl'ure from the lungs, allow the weight of the atmofphere to inflate the fponge, or on the other hand expel the air evidently changed in its properties. Be¬ tween thefe two parts, viz. the mucous lining of the lungs and the refpiratory mufcles, a ftrongand perpetual fympathy exifts. No fooner have the lungs become filled with air to a certain extent, than the ftimulus applied is conveyed to the mufcles, which contract and empty thofe organs, while the contraction of other mufcles occurs to dilate the cheft again as foon as the uncharged blood, flowing into the lungs, produces an uneafy fenfation. This fympathy brings to our confideration the 3d agent concerned in refpiration ; viz. the nervous fyftem. Thefe are the agents which apply the air to the blood. The power which applies the blood to the air, namely the heart, is likewife to be taken into confideration, as this organ and the lungs are generally connected in dif- eafe and in health. Leaving out of thequeftion for the prefent the remote injury to the brain by deficiency of blood, and to the heart by depravation of the fame fluid, and premifing that no impediment exifts to breathing in the mouth, noftrils, or fauces; we remark, that the aerial change of the blood may be imperfectly or diffi¬ cultly performed in confequence of a want of the due expanfion of the lungs; from an altered aCtion of the refpiratory mufcles; or from an altered ftate of the re- fpired air. The due expanfion of the lungs may be prevented by an alteration of ftruCture, whether of the tubes and cells, or of the fubftance, of the lungs; as by oflification, by abfeefles, by hydatids, by tumours, by condenfation of the lungs; by earthy concretions; by plethora of the blood-veflels of the lungs generally, whether pulmonary or bronchial. The due expanfion of the lungs may alfo be prevented by anafarca or by emphyfema of the cellu¬ lar membrane which connects the bronchia ; perhaps by adhefions of the pleurae; by collections of fluid in the cavities of the pleurae ; by enlargement of the heart, or by enlargement of any of the parts fo fituated as to offer mechanical impediment to the enlargement of the tho¬ rax. Oflification of the cartilages of the ribs; gibbofity; anchylofis of the joints between the ribs and the fpine; irregular aCtion of the diaphragm ; or obftacles to its de- feent, as diftention of the ftomach or of the inteftines, or paralyfma, or hydrops, may likewife be enumerated as capable of hindering the expanfion of the lungs. The aClion of the refpiratory mufcles may be dimi- nifhed by contractility in their fibres, or by want of ner¬ vous power. It will be increafed by every circumftance capable of irritating the mucous membrane of the lungs, and thus exciting fympathy, in common with other muf¬ cles, by the aCtion of the brain, or by general increafe of contractility. The air which is refpired, may be deficient as to quan¬ tity, or it may be too much rarified, or it may contain noxious panicles, or it may confift of fome noxious gas ; or, in fhort, its compofition may be altered in various ways from the natural conftitution of the atmofphere. The firft and moft remarkable mode in which the refpi¬ ratory fyftem is deranged is in what is called coughing. In this aCtion a large quantity of air, furnifhed by a con- fulerable inlpiration, is violently and fuddenly expelled, with a confiderable noife, by a very ftrong and aimoft convulfive exfpiration, and in its paflage clears away mu¬ cus, or any thing el fe which may happen to be in the air- paflages. The air may be driven out at once or at feveral exfpirations : in the latter cafe the exfpirations are con¬ tinued often as long as any air can be expelled, and the emptied cheft is again fupplied by an infpiration accom¬ panied with noife. It is obvioufly nothing but a fudden and exalted difplay of that fympathy which produces refpiration, and is generally produced by nervous ex¬ citement of the bronchial membrane. We mult not for¬ get however, that, as a fympathy exifts between the ref¬ piratory mufcles and other parts as well as the lungs, fo coughing may be induced by other caufes than the ir;i- tation of the latter organs. Thus diforders of the vif- cera of the abdomen, efpecially of thofe which lie in contaft with the diaphragm, frequently bring on a cough. A fhort dry cough is an invariable fymptom of inflam¬ mation of the liver, whether acute or chronic, and ac¬ companies the various tubercular and other obftructions in that organ. Diforders of the ftomach are, alfo, often accompanied with a cough of the fame dry and teazing nature, efpecially when that organ is over-diftended with food, or is in the oppofite condition of emptinefs. In fhort, there is fcarcely a vifeus in the cavity <■>/ the ab¬ domen, the irritation of which, in a ftate of difeafe, has not excited cough. Diforders of the fpleen, pancreas, and even the kidneys, have all given rife to this fymptom ; and external tumours, attached to them, have had the fame effeCt. (See Morgagni Epift. xix. art. 57, 58, &c.) Thus, in the afeites, or dropfy of the belly, the water; in tympanites, the air; in corpulency, the fat in the omentum; and, in pregnancy, the gravid uterus; have all, in fome cafes, the effeCt of exciting cough. Our readers fhould bear in mind, however, that each of the caufes here enumerated may injure the expanfion of the lungs permanently, and excite convulfive aCtion of the refpiratory mufcles only as a fecondary refult. But at prefent we are to confine ourfeWes to the difeuflion of 4 thofe 181 PATHOLOGY. thofe caufes of cough which have their feat in the lungs. Accordingly, in the order Pneumonica we have fix ge¬ nera. Genus I. Be.v, [Greek.] Cough. Catarrhus, Cullen. Generic character — Sudden and violent expulfion of air from the lungs. There are three fpecies. i. Bex humida, or common cough, is too well known to require a particular defcription. There are four va¬ rieties. x. B. mucofa, ufually comes on with flight fluffing of the nofe, and fenle of fulnefs in the palate and contigu¬ ous parts; a flow of mucus follows, which unloads the fecreting veflels, and a fpontaneous cure occurs. Its na¬ ture is fo generally allowed to be the fameas Catarrhus, that to that genus we muft refer the reader for a full ac¬ count of the feverer forms. (3. B. anhelans. (Dyfpncea catarrhalis, Cull.) The chronic cough of old age. This alfo can be confidered in no other light than a confequence of previous inflam¬ mation of the mucous membrane, and hence it were perhaps better to treat of it under Catarrhus ; but, as its very prolonged ftage may be merely the re fu It of in- creafed exhalation, we ftiall not difturb our nofologift’s arrangement. We take a defcription of it from the ex¬ cellent work of Dr. Haftings on Bronchitis. He fays, “The cough generally attacks the patient in the com¬ mencement of the cold weather, and fometimes conti¬ nues throughout the whole of the winter months. The mucous membrane is fo irritable, that the flighted change of temperature is fenfibly felt. The refpiration is always uneafy, and a peculiar wheezing of the breath is often prefent. The cough is molt violent in the morning, the patient never failing to cough fora confiderable time af¬ ter he awakes; and the fit feldom goes off till the air- cells are unloaded of the fecretions which have collected there during the night. Throughout the day the cough is often quiet for feveral hours together, and only comes on in confequence of increafed exertion, or when the ftomach is loaded with a hearty meal. The expectora¬ tion is copious, and ufually confifts of tenacious mucus mixed with a pus-like fluid. Sometimes, however, it is much lefs confident, and it is white and frothy. The patient has feldom any pain in the cheft, and if he have, it is flight and tranfient. Some fymptoms indicative of diforder in the digeftive organs are generally prefent. There is a fenle of weight in the epigaftric region, and the patient is frequently affeCled with pain in that part. The tongue is white and loaded, and the appetite fails. The pulfe is quicker than natural, though rarely hard. The urine is often high-coloured, and not feldom fcanty. The bowels are irregular. Such a combination of fymp¬ toms as that above ftated is common ; but we fometimes meet with chronic bronchitis which has exifted for fome time without producing much conftitutional ailment. The patient is affe&ed with cough, copious expectora¬ tion, and uneafy refpiration ; but there is no f ever, and the pulfe is not at all accelerated. Thefe fymptoms occa- fionally become the foundation of hydrothorax; but more commonly, as the warm weather comes on, the cough fubfides, and the patient’s health is reftored.” The chronic cough is however much modified, accor¬ ding to the degree of bronchial inflammation which pre¬ ceded it. When this has happened in an intenfe degree* we do not obferve, fays Dr. Haftings, the flow and gra¬ dual progrefs of the firft ftage, which is fo remarkable when this difeafe fupervenes under the forms of catarrh ; for the acute inflammation has previoufly reduced the pa¬ tient to the loweft ftate of debility, and the powers of life are funk. The refpiration is opprefled and laborious, the cough is frequent and haraffing, the pulfe rapid, and death is hourly expeCted. It however fometimes hap¬ pens, that the violence of thefe apparently-fatal fymp¬ toms is in fome meafure fubdued, and the patient gains fome ftrength,. fo as to be enabled to lit up for a ffiort time. The cough is mitigated, the refpiration is lefs laborious, and the wheezing is notfo perceptible. The expectoration, however, is increafed, though the matter expectorated is not of the fame nature throughout : fome part of it is tenacious, tranflucenf, and cannot be diffufed in water; other parts are opaque and purulent. Small quantities of blood are now alfo often intermixed with the fputa : the pulfe lofes its hardnefs, but becomes weaker and much quicker. We have generally com¬ bined with thefe unpromifing fymptoms increafed ema¬ ciation, and inability to make any mufcular exertion. Irregular fweats break out, and a flufliing of the cheeks occurs. In fome cafes, the untoward fymptoms do not proceed further; they gradually amend. The expectoration di¬ minishes, the cough is lefs haraffing, and the refpiration not fo uneafy. The patient begins to gather a little ftrength, and the appetite returns. A change of air and’ favourable feafons are particularly advantageous at this period, and by thefe means the patient frequently reco¬ vers his health, although months fometimes elapfe be¬ fore fuch progrefs is made as enables us to fpeak with any confidence as to ultimate recovery. But, if no fuch alte¬ ration in the charaCIer of the diforder take place, a greater degree of general debility occurs, with a further lofs of fleffi. The cough becomes extremely haraffing, the refpiration more quick and laborious. The expe&o- ration increafes, and is more purulent in its appearance. The pulfe is rapid. During the night general perfpira- tion breaks out, and the face in the day is often flulhed. The patient can ftill, for the molt part, take a deep in- fpiration without pain, and lying down does not produce much increafe ofdyfpnoea. He feldom complains of any ftiooting pain in the breaft. Even from this almoft hope- lefs ftate patients occafionally recover ; but, when the difeafe has exifted fo long as tocaufe extreme emaciation and very copious pus-like expectoration, there is little or no hope. It fometimes happens that dropfical fymptoms come on before death. In the treatment of this complaint, our firft endeavour ffiould be directed to moderating the force of the circula¬ tion, which is fometimes, though rarely, extraordinary; more frequently it will be merely neceflary to diminiffi local plethora by leeches; after this, the irritable ftate of the mucous membrane may be checked by blifters and rubefacients, or iffues, which may be fteadily perfevered in. It is a remarkable faCt, noticed by Dr. Haftings, that, during the ufe of thefe counter-irritants, purulent expectation is occafionally converted into the iecretion of natural mucus. Emetics have often been recommended in that variety of chronic bronchitis which appears in old people, and is denominated tuffis fenilis. The cough and dyfpncea are in fuch cafes much aggravated by the accumulation of redundant Iecretion in the trachea, bronchia, and air- cells, which* by the adtion of vomiting, is frequently thrown up. Whenever, therefore, the lungs appear loaded with phlegm to any great degree, they may be re¬ lieved by an emetic : but this pradfice does not appear to have much eft'edt in forwarding a radical cure. The tinCre of meadow- faffron (Colchicum) poflefles very remarkable powers in chronic cough. It allays the cough, promotes the flow of urine, and keeps up a regu¬ lar alvine difeharge. Moreover, from the power it pol- fefles over the fecretions, this medicine tends to relieve fever. The dofe generally preferibed is twenty drops three times a-day. In fomecafes this muft be diminiffied on account of its aftion on the bowels, fevere diarrhoea being occafionally brought on by its ufe. Sometimes the patient is not affefted by twenty drops : if this ffiould happen, the dofe may be gradually, increafed, until the bowels, the Ikin, or the kidneys, are a<5ted upon. Pa¬ tients rarely bear more than thirty drops three times a- day without being a good deal purged, which is not to be defired in prolonged cafes of this difeafe. If there be much. 182 PATHOLOGY. much quickrefs of the pulfe, eight or ten drops of the tincture of Digitalis, or foxglove, may be combined with this medicine; a combination by which the cough is more relieved, and the quicknefs of the pulfe more per¬ manently diininiftied, than by the fe pa rate exhibition of either. While we have reafon to fufpeft a congefted ftate of the capillaries of the mucous membrane, we rnuft peril ft in low regimen, the life of Digitalis, Colchicum, &c. as we (hall mention when fpeaking of catarrh; but, when the complaint prefents much irritation or relaxation of the fecernent veffels, more ftimulating medicines are ufeful. In having recourfe to thefe, however, we muft be careful not to ltimulate too fuddenly or too much, as we have to deal with a ftate of parts much difpofed to refume inflammatory aftion. It is therefore advifable to 'pegin with the mildeft of this clafs. The powder of the bulbs of the Scilla maritima is often ferviceable in chronic cough. Dr. Haiti ngs exhibited this powder in conjunc¬ tion with ammoniacum, as diredted in the compound i'quill-pill of the London Pharmocopceia ; and in old people of phlegmatic habits, when there is not much fever, he found it very ufeful. Witli the fame view Dr. Haftings has exhibited Cin¬ chona chiefly in thofe inftances that fucceed to acute bronchitis, where the debility brought on by the acute attack is very confiderable. In fuch cafes, if the dyfp- ncea be not increafed, the benefits arifing from its exhi¬ bition are fometimes very apparent. The profufe perfpi- rations and other difcharges are not only reftrained by this remedy, but it occafionally appears to alter the fe- cretion from the mucous membrane of the lungs, and thus brings about a more healthy condition of that mem¬ brane, by invigorating its blood-veflels and reftoring their natural tone. In thefe cafes it may be combined with diluted fulphuric acid, which alfo tends to reftrain the colliquative fweats that fo often accompany this dif- ea fe. The ufe of mercury in fome varieties of chronic bron¬ chitis greatly aflifts the operation of other remedies; but it muft be given in fuch a way as to produce the leaft poflible debility of the fyftem. We have before noticed the efficacy of this medicine in bronchitis arifing from gaftric and fibrous difturbance. But there are cafes in which it is advantageous in chronic bronchitis uncom¬ bined with any difeafe in the abdomen. Thefe fometimes occur after meafles, when the fnrillnefs of the voice in¬ dicates confiderable affedtion of the mucous membrane lining the trachea. Indeed the great advantage we de¬ rive from calomel in croup would lead us to adopt it very conftantly in fimple inflammation of the bronchial membrane. But the debility produced by this difeafe, when of a chronic nature, forbids the ufe of a remedy fo debilitating. In the latter ftages of chronic bronchitis, where the quantity of matter expe&orated is very large, and the cough very troublefome, there is no remedy fo powerful in allaying the uncomfortable irritation about the glottis as opium. But, valuable as this remedy is, it is not always free from inconvenience or danger, and confe- quently other remedies of this clafs have been propofed as fubftitutes for it. Dr. Duncan has ftrongly recom¬ mended la&ucarium when opium cannot be given. He fays, “Of all the medicines which I have employed for alleviating cough in phthifis, and indeed as a fedative in many other difeafes, next to opium, I have found no article fo beneficial as that fubftance which fome have lately denominated lettuce-opium, and which I term tu&ucarium." When inflammation is not apparent, inhalation of tar- water may be a gentle ftimulus of fome avail in altering the morbid aftion of the veffels. The ftritleft attention ihould be paid to the due performance of the digeftive and excretory functions. The clothing muft of courfe vajy according to the feafqn and fituation. The patient fiiould endeavour to obtain moderate but not opprtfiave warmth. In this climate, flannel next the Ikin during the fpring and winter months, by (lightly ftimulating its veffels, fuftains the circulation on the furface, and thus tends to relieve chronic inflammatory difeafes of the pulmonic fyftem. When the difeafe has feveral times returned, and is eafily brought on by viciffitudes of tem¬ perature, a removal to a wanner and more Heady climate is proper. Under thefe circumftances a pure and dry air fnould be felefled, as a hot fituation conjoined with m oi ft u re is always to be avoided. The lea-air during the fummer-months, in thole who live in an inland fitu¬ ation in this country, fometimes invigorates the confti- tution, and reftores the tone of the veffels on the bron¬ chial furface, fo as to prevent a return of the difeafe-, where former attacks have left a fufceptibility to inflam¬ matory adlion. The two following varieties are given on the authority of Dr. Good ; but their feparate exiftence, affumed on the different appearance of the fluid difcharged, does not feem fupported by practical writers. They are, y. B. acrida ; the difcharge thin, frothy, and faline ; for the molt part excreted with difficulty. It is in mo ft inftances an atonic affeftion of the lungs or of other or¬ gans that affociate in their adlion. Sometimes an atten¬ dant upon the gouty; more frequently upon inebriates labouring under a difeafed liver, to whom it is peculiarly troublefome in the morning. B. periodica ; recurring at Hated periods : partly reftrainable ; difcharge thin, but not acrid. Moftly common to perfons of a nervous or hypochondriacal tem¬ perament. 2. Bex ficca, or dry cough; i.e. unaccompanied with expe&oration. Three varieties. «. B. ingenerata ; from irritation produced locally, as a fcirrhous or calculous affeftion of the lungs. See Bo¬ re] li, obf. 6. arid Zacut. obf. 95. (3. B. extranea ; from irritating materials inhaled from without, as minute particles of glafs, lime-ftone, and fimilar bodies; and common feo glafs-cutters, hewers of free-ftone or fand-ftone, workers of metals, and other mechanics. In manufadluring towns, the preparers of yellow leather, and thofe employed in fome parts of the china manufactory, are often fubject to fevere attacks of this kind. They are expofed during fome parts of the procefs to inhale an air loaded with dull, which produces inflam¬ mation of the bronchial membrane of a chronic and pe¬ culiar nature. Dyfpncea is generally the primary fymp- tom, which is often neglected for many months. If the occupation, under thefe circumftances, be continued, the difeafe is aggravated. The patientis not unfrequent- ly feized with harmoptyfis, which is occafionally very profufe, and is accompanied with a great increafe of dyfpncea, and fevere cough. The pulfe too becomes ac¬ celerated, and is generally hard and ftrong. The furface is hot, the tongue white, and there is confiderable thirft : occafionally bluenefs of the lips and general lividity of the countenance alfo appear. It often happens that we can arreft the haemorrhage by blood-letting and aft rim- gents; but in moll: cafes of this delcription, the haemop- tyfis is followed by very untoward fymptoms. Whether haemoptyfis have come on or not, if the bronchia be ftill fubjeded to irritation, the cough increafes, and is atten¬ ded (for it is by no means true that extraneous fubllan- ces always produce a dry cough,) with a copious expec¬ toration of thick mucus, which is mixed with pus-like matter, and fometimes ftreaked with blood. “The pa¬ tient complains of an uncomfortable tightnefs acrofs the cheft, and the dyfpncea does not abate. He lofes flefii, the pulfe becomes quicker, the tongue continues loaded, and there is confiderable thirft. In by far the greater proportion of thefe cafes, if the occupation be relinquifh- ed, thefe fymptoms, by an appropriate treatment, difap- pear, and the patient is reftored to health. In others the termination PATHOLOGY.' 188 termination of the difeafe is not fo happy. The patient emaciates; he has profufe night-fweats, and the cough l’.arafl'es him to fuch a degree as to prevent his reding by night. The expectoration is prodigious, and becomes much more purulent. The dyfpncea is greatly increafed, the pulfe is very quick, and there are regular evening exacerbations. The patient at length dies exhaufted.” Haftings) 275. B. verminofa ; from worms in the intedines, liver, or other abdominal organs. Common to children with large bellies, and pale emaciated countenances; and dill more fo to dieep labouring under the difeafe- called rot, and vvhofe livers are uiually loaded with the Fafciola hepatica, or fluke. 3. Bex convulfiva, (Pertuflis, Cull.) Whooping- cough ; chin-cough, "or more correCtly kin-cough or kind-cough ; literally “ child’s cough,” from the Ger¬ man kind, achild. The cough con vulfive, and fufFocative, accompanied with a fhrill reiterated whoop, and frequent¬ ly with vomiting ; contagious. This malady commences as an ordinary catarrh. In the fpace however of a fortnight or three weeks, the fymptoms undergo a change, and the difeafe exhibits a convulfive cough, in which the expirations are made ■with fo much rapidity and violence, and are fo long and frequently repeated, that the whole air feems to be ex¬ pelled from the lungs, and the patient appears to be in danger of fuffocation. At length a full ajid violent in- fpirption is necelfarily made for his relief, which, from the iinufual velocity with which the air rufhes in, or from the fpafmodic contra&ion of the glottis, produces a peculiar found or whoop: thefe actions alternate until mucus is expectorated, or the contents of the ftomach partially ejefted. Thefe evacuations commonly put an end to the coughing, and the patient remains free from it for fome time after. But the duration of the paroxyfm and the relief obtained are very different in different in- ftances. Frequently the expeftoration or vomiting takes place after the firft or fecond coughing; but fome- times this happens only after feveral alternate coughings and whoopings; and, in very fevere cafes, the paroxyfm ends in the complete exhauftion of the patient, without any difeharge whatever. The fits of coughing return at various intervals, rarely obferving any exaft period. They happen feveral times in the courfe of the day, and more frequently in the night. In general they come on without any obvious caufe ; but they are alfo brought on fooner and more •violently by various fources of irritation, as by confide- rable bodily exertion, fuch as running, or even laughing, turning from fide to fide in bed, diftending the ftomach by food, or irritating it by fuch as is indigeftible or acri¬ monious. Fretting and crying commonly bring on the fit. Though the paroxyfms come on fuddenly, the pa¬ tient has commonly fome warning, which excites his alarm ; and, to avoid the violent and painful concufiion which the coughing occafions to the whole body, he fometimes throws himfelf on the ground, or clings faft to any thing that is near him, or demands to be held faft by any perfon that be can come at, and will even run acrofs the room for that purpofe, with terror and fup- piication exprefled in his countenance. In alrnoft every cafe of the difeafe, dyfpncea is prefent. Frequently there is a difficulty of breathing, not only immediately before and after the •fits of coughing, but, in the more fevere cafes, the patient pants on the leaft exertion, as if he had run a race, or performed fome feat of bodily ftrength. When there is little expecloration, and that of a thin mucus only, the fits of coughing are violent, and conti¬ nue long : but, as the expefforated matter foon becomes confiderable and very thick, as it is more readily expec¬ torated, the fits of coughing are of fhorter duration. If the fits are violent and long continued, they necelfarily interrupt the free tranfmiffion of the blood through the lungs, and confequently the return of blood from the Vjjl. XIX, No. 1256. head. This gives rife to turgefcence and fufftifion of the "'face, and fometimes occalions haemorrhage from the nol'e. Sydenham fpefks of the whooping-cough as unconnec¬ ted with fever; Dr. Cullen remarks, that “It is conr ftantly in fome degree prefent ; but with evident exa¬ cerbation towards evening, continuing till next morn¬ ing.” (Firft Lines, mccccx.) Dr. Watt alfo obferves upon this point, “as far as tny experience goes, I am difpofed to believe, that, even in the miideft cafes, as- long as the kinks (paroxyfms) continue, there is always fome part of the day when the prefence of fever can be dete&ed. It may be fo flight as hardly to deferve no¬ tice ; but (till, to an attentive obferver, who has oppor¬ tunities of feeing the patient day and night, it is abun¬ dantly obvious. I have remarked it even in thofe fa¬ vourable cafes, where the appetite continued good, and where the patients feemed to fuffer little or nothing in their general health.” Indeed the phenomena of increafed heat and aflive pulfation have been fo generally noted, that it feems furprifingthat they fhould haveefcaped Sydenham’s (ufu- ally) dole obfervation. With regard to the nature of whooping-cough, it feems evidently a fpecies of bronchitis, or inflammation of the mucous membrane of the lungs, which has thefe. circumftances peculiar to it, that it elicits a fecretion pofleffing contagious properties, and that it is connected with fpafmodic action of the mufcles of the glottis and of the cheft. The low degree of febrile irritation it fome¬ times produces will prevent many from according the term inflammation to the malady. This is however of no confequence ; the prefence of difeafed fecretion no one will deny 5 and that the irritation this arifes from is very prone to bring on unequivocal fymptoms of inflamma¬ tion, is equally indifputable. Dilfeflion of fatal cafes has invariably fhown rednefsand diftentionof capillaries on the nervous membrane, or effufion of pus or flakes or coagulated lymph. In fome cafes diforganization has been propagated to the fubftance of the lungs. In fopie very young fubjedts, indeed, fuffocation has occurred from the long irritation of the mucus having kept up coughing till the cheft was emptied of air, and the glot¬ tis has been clofed, firft by the fpafm of its mufcles, and afterwards by the preffure of the atmofphere ; and here diffedtion has furniffied little evidence of inflammation.. The courfe and event of this difeafe are very uncertain. In the miideft form in which it appears, it commonly continues from one to three months; and, in the more, fevere, con.fiderably longer. Even after it has nearly or wholly ceafed, an accidental expofure to cold occafions a relapfe. The treatment of Bex convulfiva follows clearly out of the views before taken of its nature. I11 the firft place, we have to guard againft inflammation fpreading to any alarming extent. In proportion, therefore, as the dyfp- ncea and fever are fevere, and as the patient is ftrong and plethoric, it becomes necelfary to employ blood-letting, and even to repeat it according to the urgency of the circumftances. Even in more delicate and younger chil¬ dren, fome evacuation may be neceffary by means of the lancet, in the commencement of the difeafe; and local bleeding, by leeches applied to the cheft, may be reforted to, where general blood-letting is deemed inadmiflible. The difficulty of the tranfmiffion of blood through the lungs fhould be watched* and early attacked by this effi¬ cient remedy, or the difeafe will often baffle all the fub- fequent efforts that can be made. Moreover the treat¬ ment of dyfpepfia fhould be kept clofely in view. The inflammation of the membrane, and the convulfive aflion of the refpiratory mufcles, are of courfe connected with nervous irritation ; and hence we muft be careful that all excitement of the nervous fyftem be withheld. Ab- ftemioulnefs and the ufeof purgatives have the two-fold effect of inducing a right aftion of the chylopoi’etic vif- cera, and of diminifhing inflammation, 3 B Every 184 PATHOLOGY, Every practitioner muft have ohferved the almoft con- ftant derangement of the excretions of the bowels, under any acute difeafe in children, but more efpecially under tbofe affefting the lungs ; and the relief obtained, even in refpeCt to the original diforder, by regulating the al- vine difcharges. It is important, therefore, when the difeafe affumes an inflammatory type, to keep up a con- ftant free (fate of the bowels from the fir ft, by the repeated ufe of laxatives, efpecially of thofe which contain a por¬ tion of calomel. According to the ftate of aCtual con- ftipation, or of mere derangement of the excretions, the purgatives will be ufed more actively at intervals, or more conftantly in fmaller dofes. Of all other remedies, emetics appear to be among the moft ufeful in this difeafe ; for they not only determine the fluids to the furface, and ftill more effectually relieve the lungs by promoting its fecretions, but they alfo tend to interrupt the recurrence of the fpafmodic affeCtions. As a fecondary expedient, with a view to obviate or re¬ move inflammatory determination to the lungs, when it occurs in this difeafe, the application of blifters is often beneficially reforted to. They do not, however, appear to aCt fo beneficially in the relief of the pain and dyfpnoea attending this difeafe, as in ordinary cafes of catarrh; and ought not to be relied on, where the inflammatory con- geftion in the lungs is confiderable. They are moft be¬ neficial, when this inflammatory condition has been al¬ ready partly fubdued by the more aCtive evacuations. The medicines generally in ufe in thefe complaints are the fame as in the common forms of bronchitis ; viz. di¬ gitalis, colchicum, &c. The alkalies, foda and potaflt, have alio great influence on this complaint. To allay the nervous excitation, conium and hyofciamus may be advantageoufly prescribed ; the warm bath Should be ufed occasionally, and reft absolutely enjoined ; for, whether we view' the mere Symptom of dyfpncea, or extend our refearches to the probable caufe of its occurrence, we Shall find ample reafon to induce us to keep the lungs in as tranquil a ftate of action as poffible. It is in this way indeed that bleeding in all pulmonary difeafes muft be principally ufeful ; viz. that the diminished quantity of blood in the fyfteni calls for lei’s activity in the refpir- ing powers. Thefe rules apply, however, only to Severe cafes. In the ufual mild forms, a regulated diet, pure air, and medi¬ cines of an aperient nature, with an occafional emetic, will accomplish all that is required in the firft ltage of the diforder. In the after Stages', when the operation of the conta¬ gion may be fuppofed to have ceafed, and the convulsive cough to be continued through the influence of habit, a different indication arifes, and different remedies are to be employed. That the power of habit contributes to keep up the difeafe, after the influence of contagion has de¬ clined, is to be inferred from the circumftance that the fymptoms have disappeared, like other nervous Symp¬ toms, in confequence of the impreflion of terror, or other Strong emotions of the mind ; which agents cannot be fuppofed to have the power either of correcting or ex¬ pelling a morbific matter from the conftitution, but which are evidently Suited to change the ftate and ha¬ bits of the nervous fyftem ; or, at all events, of inducing a change in the merely habitualdiforderof the fecernents. With this view, the inhalation of tar vapour may be re¬ forted to with advantage. Some authors have advifed a variety of tonics ; but their mode of aftion is obfcure, and general experience has not confirmed the original accounts of their efficacy. A Stimulant more congenial to the bronchial membrane is country air. Indeed change of air has been very generally deemed the moft effectual remedy in the advanced ftages of the difeafe. And fo Strong has this impreflion been made upon the public, that it has been generally believed, that any change of air, even from a better to a v/orfe, is beneficial. This, however, Seems improbable; and the fact perhaps is as Dr. Watt has Stated it : “It no doubt frequently happens,” fays that writer, “ that a child is better on being taken from one place to another, even when the air in the latter place. is fuppofed to be worfe than the former. Here, however, I fnould be difpofed to attribute the good effeCts, not to coming into a more impure at- mofphere, but to the child’s being abroad , any atmol- phere being better than confinement to the houfe.” This advice is not of courfe meant to apply to any but cafes in which the inflammatory tendency of the cough is per¬ fectly fubdued. But we muft not forget to mention, that a refpeCtable author has oppofed the notion that change of air is al¬ ways beneficial to patients of whooping-cough. Dr. Ro- bertfon has Seen Some lamentable instances to the con¬ trary. He thinks the removal Should be but a Short dif- tance from home, “and the new abode Should be choferi in every thing refembiing the former one,” avoiding ele¬ vated and expofed Situations, as well as thofe that are too low and damp, or within the range of exhalations from Stagnant waters or flooded meadows. Inland Situ¬ ations are preferable to the coalts. The advantages of change of air, he thinks, may Sometimes be obtained by change of rooms and habits, at home. Upon the whole we are of opinion, that, as a general meafure, change of air, or, at any rate, being much in the air, is advisable ; but, like other good rules, it is liable to fotne exceptions. Dr. Archer, an American phyfician, advifes to relieve the whooping-cough by vaccination. This, of courfe, can be reforted to only under particular circumstances. Dr. A. fays, “ I have vaccined fix or eight patients that had the whooping-cough, and in every cafe it has fuc- ceeded in curing this moft diftreffing difeafe. The whooping-cough does not come to its height in lefs than fix weeks from its commencement; and then, when a favourable termination is expefted, the declenfion of the difeafe is gradual, and it does not terminate in lefs than fix weeks more. To arreft this afflicting diforder in its progrefs, I would recommend vaccination in the fecond or third week of the whooping-cough, i. e. when the fymptoms of the whooping-cough are fully afcertained, then to vaccinate. Should the convulfive cough be vio¬ lent, I Should immediately vaccinate ; being well allured that the diftreffing fymptoms of the whooping cough are checked by vaccine diS'eafe. The termination of the vac¬ cine difeafe will be the termination of the whooping- cough.” Genus II. Tdyfrnaa, [from Sw;, bad, and mice, to breathe.] Anhelation. ‘Permanent difficulty of breath¬ ing, with a fenfe of weight on the cheft. Dyfpnoea is produced by fo great a variety of caufes, and from its very nature is fo evidently fymptomatic, as in faff Parr and the belt fyftematic writers have always considered it, that we Shall refer our readers to the origi¬ nal maladies which give rife to its varieties for the necef- fary details concerning it. It may be pradtically ufeful, however, to remark, that an unremitting difficulty of breathing is common to fome old perfons, in whom its long continuance, and the ab- fence of other fymptoms, forbid us to fuppole any orga¬ nic change in the Structure of the lungs or contiguous vifeera, or indeed any merely mechanical obstruction, to have occurred. It differs but in a flight degree (as far as our own opportunities of Seeing it have extended) from afthma: the point of difference between the two com¬ plaints is merely the regular and continuous diforder of refpiration in the former difeafe, as antagonized to the paroxyfms or exacerbations of the latter. There are two lpecies. i. Dyfpncea chronica, or Short breath : breathing uni¬ formly Short and heavy, moftly accompanied with a cough. There are five varieties. a. D. 185 PATH OLOG Y to. D, extran'ea, (D. terrea, Cull.) From calculous or other earthy fecretions in the fubftance of the lungs thrown up by coughing. See Catarrhus, in this article. 0. D. phlegmatica, (D. aquofa, Cull.) The habit phlegmatic or cachectic, with fcanty fecretion of urine, and moltly oedematous extremities. See Hydrops, in this article. y. D. pinguedinofa, or purfinefs ; accompanied with oppreffi.ve fatnefs. See Corpulence, in this article. o. D. organica, (D. thoracica, Cull.) From deformity or organic defect, or injury. e. D. vaporofa j from the mifehievous a&ion of metals or other poifons,. i. Dyfpncea exacerbanst SuhjeCt to fudden and irre¬ gular exacerbations: the breathing deep, ftertorous, acute, and Suffocative; relieved by an ereCt polition. This, when not Symptomatic, is the fame as the follow¬ ing genus, varying from it only in its acutenefs and violence; it requires a fimilar treatment. Found, alfo, under the one or the other fpecies, as a Tymptom in aneurifms, polypous concretions, and other affections of the heart and larger veflels; in enlargements and other a (left ions of the abdominal vifeera ; in empyema, iiydrotborax, worms, peripneumony,baftard peripneumo- ny, fmall-pox, and occalionally in fevere attacks of inter¬ mitting fevers. Some au thors have explained the term Catarrhus fuffo- cativus (the name by which this fpecies is called by Baglivi and others) as Synonymous with croup. Genus III. Afthma, [probably from ctw, I breathe.] Difficulty of breathing, temporary, recurrent ; accom¬ panied with a wheezing found, and fenfe of conftriCl ion in the cheft; with cough and expectoration. Thefe ge¬ neric characters are fubjeCt to great variations. Afthma lias of late years been traced in a very large proportion of cafes to organic changes in the thoracic vifeera. As there leeins good reafon, however, to believe, that the majority of afthmatic patients (perhaps nearly all where the complaint is not of long Handing or of peculiar vio¬ lence) Suffer from functional impediment only, we con¬ fine ourf elves to the confideration of afthma of this latter kind. The exaCl nature of afthma is not fettled. Among the ■old writers, Floyer paid much attention to this difeafe, with which he was feverely aftlidted ; but his opinions as to its caufe are fo much tainted with the humoral doc¬ trines, that it is ufelefs to difeufs them. He has left, however, a very good description of the Symptoms of one kind of afthma. Cullen fuppofed it to confift in a fpaf- modic conftridiion of the mufcular fibres of the bronchia, preventing the free ingrefs and egrefs of the air, and con¬ sequently the due expanfion of the lungs. This opi¬ nion, however, is not reconcileable with the known ftrudhire of the bronchia, and lias accordingly been laid afide. The fame author mentions feveral varieties of it, as exanthematicum,fimplex, phlegmaticum, plethoricum, &c. arifing from remote and diftindt caufes. Thefe Dr. Good has adopted in his Nofology ; but the Amplified arrangements of pradfical writers feem to warrant the difmifial of Such divifions. Dr. Bree, in the belt treatife on this Subject which we know of, confiders afthma, pro¬ perly Speaking, and as diftinguifhed from mechanical preffure of all kinds, whether tumors, concretions, or other confequences of inflammation, to be a material irritant applied to the air-cells of the lungs, and exciting the contraction of the refpiratory mufcles for its remo¬ val. To take in his juft and more extended view of the difeafe, we quote his own words. He fays, “ If it be ne- cefiary to define the difeafe, I would fay, agreeably to the principles of the following inquiry, Afthma is an excef- hve contraction of the mufcles of refpiration, without acute lever, excited by an irritation in Some of the vifeera whofe functions thele mufcles are intended to ferve. Under this generic definition are comprehended all affec¬ tions not febrile, attended by an uncommon adtion of the mufcles ufed in refpiration ; the influence on thefe mufcles being the fame in kind, though diftindt by fitu- ation and quantity of force, as it may exill in fome of the lower vifeera, or in the lungs.” Now, as far as regards the lungs, the material irritant productive of afthma is fuppofed to be a mucous fecre¬ tion. Dr. Bree deduces, from a valt ftore of ancient and modern authors, observations tending to (liow, that the paroxyfm of afthma'is ahnoft invariably connedled with, and terminated by, the expectoration of mucus or Serum : and he infers, that the impediment to refpiration arifes from the gradual collection of this fluid in the air-cells. There it may exift for a certain time without producing dilturbance ; but at length the filling up of the remote terminations of the bronchite impedes the changes of the blood, and calls into forcible adtion the refpiratory mufcles; whereas the lymph accumulated in the air-cells is rather oppreffive than acrimonious, and the fenfib'.lity of their membrane is lefs than that of any part of the bronchia and trachea. Moreover the veficle cannot col- lapfe in the attempt at expiration, becaufe its cavity is filled with lymph. Hence Dr. Bree thinks arifes the true caufe of a paroxyfm, “ beginning with little or no cough, and that Seemingly impeded but, after the fluid has been leflened by abforption, Still more may be discharged in the vapour of expiration, and, the elafticity of the bronchia being thus reftored, the much-defired fpitting of mucus may take place. We copy from this author the following lucid account of his opinion-s as to the production and -nature of this Se¬ cretion. “It is obvious, that mucus could not have been expeCtorated without a previous Secretion of ferum. But, as this mucus is copioully discharged, the effufion of Se¬ rum mutt have been confiderable : it may be therefore proper to inquire in what ftate of the lungs fuch an effu¬ fion can take place. It is known that the glandules of the trachea and bronchia are fubjedt to inflammation, and that in catarrh an excretion of mucus is confiderable from this condition of their veflels; but practitioners have generally teftified, that pyrexia and Symptoms of inflammation are not prefent in fpafmodic afthma. We muft then look farther for the fource of this copious fe¬ cretion, and we (hail find it in the veflels with exhalent orifices at the extremities of the air-pipes ; the conftruc- tion of which is not complex like that of the mucous glandules; and they have not follicles in which they may depofit their lymph till it be excreted. There are many reafons for believing this to be the principal, if not the only, fource of the copious expeCforation in afthma.” In confequence of the condition of the habit in afthma, the matter of heat is not given out in this as in other in- ftances of glandular Secretion. Thecapillary veflels are paffive in this difeafe; and, not contraCfing So narrowly as to detain the grofs part of the current, they permit lymph to pafs inftead of exhaling only a thin vapour. It Seems that, in the early periods of afthma, and while ferum is not very abundantly effuled, a quicknels of ref¬ piration commonly precedes the paroxyfm, and the ex¬ pirations carry off, in vapour, that fluid from the cavi¬ ties : the aCtion of the abforbents is probably alfo quick¬ ened, fo that, by the united powers of thefe inftruments, the balance may be reftored between abforption and ex¬ halation. There can be little difficulty in according to Dr. Bree, that this explanation is very plaulible and fatisfac- tory, and that irritation of mucus on the nerves of the bronchia is no doubt in many cafes the proximate caufe of afthma. Every one muft allow, however, that'any cir- cumftance inducing an irritable ftate of the nerves will as furely produce the difeafe as the fecretion does; and it is of little confequence what irritant is applied to thefe nerves, Since we find cough and difficulty of breathing produced by a variety of ailments, as in the liver, womb, kidneys, See. We therefore confider afthma the refult of irritation 386 PATHOLOGY. irritation of all tliofe parts which hold a fympathy with the refpiratory mufcles. Indeed Dr. Bree’s opinion does not differ widely from this, as he has allowed that afthma frequently has its origin in biiious and gaftric difturbance. A further evidence in favour of this notion is, that fome afthmatic patients -do not, not withllanding violent ef¬ forts, expectorate ferum or lymph. The wheezing noife, and the ftraitnefs and anxiety, gave Cullen reafon to fuppofe that a conftrittion of the bronchi® took place in afthma. Dr. Bree thinks their fymptoms may be more fatisfadtorily traced to detention of the ftomach and cefophagus ; when in the former part, preventing free infpiration by hindering the defcent of the diaphragm ; when in the latter, narrowing the bron¬ chi® by preffure. But the mod dyfpeptic patients of afthma do not invariably fuffer the above fymptoms in the higheft degree. It feems clear therefore, that, though contraction of the bronchia is almoft impofiible, a partial cloftireof the glottis may occur from fpafm of its muf¬ cles, and produce the phenomena in queftion. Indeed thefe mufcles are as intimately involved in fympathy with the bronchial membrane as the external mufcles of refpiration, and confequently are liable like them to have this fympathy when kept up for too long a period by ir¬ regularity or difturbance in the times of their contrac¬ tion and relaxation. We now come to fpeak more par¬ ticularly of the two fpecies into which Afthma is divided. 1. Afthma ficcum, dry, nervous, or convulfive, afthma : paroxyfm ludden, violent, and of ftiort duration ; con- ItriClion hard, dry, fpafmodic; cough flight; expectora¬ tion fcanty,and only appearing towards the clofe of the fir. We have before ftated that the convulfive efforts of the mufcles of refpiration in this complaint may be called into play by irritation of any part of the body the nerves of which have influence over thofe mufcles in a ftate of health ; fo that dyfpepfia, or difturbance in the liver or in the bowels, or even in the uterus, may give rife to diffi¬ culty of breathing by impeding the defcent of the dia¬ phragm, or by increafing or diminifhing the fympathe- tic motion of any of the other refpiratory mufcles ; and, as the aClions of the former vifcera are periodical in health and in difeafe, the periodic occurrence of nervous irrita¬ tion will influence in the fame irregular mode the dyfp- ncea, and caufe afthma. It is in afthma arifing from thefe abdominal irritations that many anomalous fymptoms occur. General ner- voufnefs, itching of the Ikin, flufhes of heat, diabetes, hyfteria, See. are of no uncommon occurrence; but the complaint is too ftrongly diftinguiflied from any of thofe complaints to render us liable to miftake in our diagnofis. From what has been before ftated, it feems that the -caufes of afthma are, nervous irritation of the bron¬ chi®, affecting by fympathy the mufcles of the cheft and glottis ; or the lame irritation of other nerves fitnilarly connected. The fecond caufes are embraced in the ex- tenfive views we have taken of dyfpepfia : the former can arife only from the peculiar ftate of the bronchial exha- lants already mentioned, or the bad ftate of the air in¬ haled. It remains therefore only to fpeak of aerial irritation. In the firft place, it nnift be remarked, that the ftate of the bronchial membrane will much alter the nature and force of the impreflions it receives from the air. Dr. Bree fays, the fenfible membrane of the trachea is na¬ turally defended by its lymph from the attack of aerial acrimony, as far as the condition of bodies varying in fenfibility to external impreflions will admit of this de¬ fence. Other things being equal, this guard is fufficient, and anfwers the purpofe for which it was defigned. But, if the fecretion of lymph from this membrane be defi¬ cient, and the abforbing power be aClive, the furface of the membrane may be irritated by a thoufand impercep¬ tible points which the air conveys in the aft of infpi- jation. The ftate of air moft congenial to the afthmatic patient appears to be that of denfity, a' ftate which more than counterbalances the ill effeCts of foreign particles with which it is often loaded ; and hence, in the majority of cafes, the air in low fituations is more favourable to the lungs of afthmatic patients than that of the high lands-. It feems moreover, that, even if impurities of the air ought to be confidered as the aerial caufe of afthma, thefe are more ftrongly applied to the lungs in rare than in denfe ftates of the atmofphere, fince in the latter they are fufpended at an altitude fuperior to that of the human frame. Dr. Bree accounts for the good influence of denfe air on afthma by ftating, that a certain weight of air is ne- ceffary to inflate the lungs fully; and that, the greater the force of preffure thus applied, the more perfectly will the aerial particles required for the blood be forced through the bronchial membrane, or through the collec¬ tions of ferum which its tubes may contain. He men¬ tions experiments on animals, in which the abforption of oxygen was effected with great fpeed when artificial pref- fure was applied. He fays, moreover, that, “the ufual denfity of the air being lefiened, a certain volume will not only poffefs lefs weight, and prefs lefs againfl the membrane, but it will alio contain lefs oxygen to enter into the new affinity.” So much for the ftate of the air as far as regards its immediate tranfmiffion to the bronchial membrane. Its temperature exerts itfelf with equal power on the Ikin. Cold and moifture check cutaneous perfpiration, when the body is under their influence : there is therefore ad¬ ditional fluid circulating to the pulmonary exhalents, and there is lefs expiration of vapour in breathing ; fo that we have, in this ftate of the atmofphere, an exciting caufe of afthma as frequently as in that of moifture with rarity of air. Cold alone will fometimes, but not com¬ monly, excite the paroxyfm ; for there may be ftates of the atmofphere inducing great torpor on the pulmonary exhalents, without the prefence of aqueous vapour, or moifture. Thus, the eaft and north-eaft winds would exert the beneficial influence which coldnefs, Amply united with denfitj' of air, has on refpiration, were it not that thefe penetrating winds check cutaneous perfpi¬ ration, and thereby induce another caufe of afthma by this matter being turned upon the lungs. So on the other hand, in fummer and autumn the atmofphere is rare, and fo far hoftile to the afthmatic; but, to leffen this inconvenience, he enjoys the grateful lenfe of a warm Ikin, and general perfpiration, as the circulation is determined to the furface during thefe feafons. “ If (fays Dr. Bree) it were not for this diverfion in favour of the lungs, the patient would perceive much more of his complaint than he really does in the warm feafon ; for many circumftances operate againfl him then which do not in winter.” The exhalation from the pulmonary veffels, decidedly increafed by exercife or other caufes, will oftener be prdfufe in the hot months; and be more fuddenly followed by the coldnefs, which is known to come upon furfaces in proportion to the evaporation made from them, than happens at cold periods of the year. This view of the modus operandi of the atmofphere is more confonant with legitimate deduction from fafits than the old notion that vapours in the air were all the offending agents to be looked to, fince it is notorious that many afthmatic people live better in the crowded and fmoky precin&s of a large city than in the open air of the country. Sometimes, indeed, fumes, dull, &c. are eafily proved to lead to, or aggravate, an afthma; but generally we cannot well confider aerial impreflions to be the exciting caufes of the paroxyfms of this malady, fince, fuch impreflions being conflant, the cough and difficulty of breathing would be equally fo. We muft therefore conclude, that the particles of matter contained in foul air accumulate in the bronchia, and affimilate with its fe- cretions, until their bulk brings on the dyfpnoeic pa¬ roxyfm. PATHOLOGY. We (hall tranfcribe Dr. Bree's account of the fymp- toms of this complaint. It bears a clofe refemblance to the noted defcription given by Floyer, but is perhaps more amply detailed. “The attack of a paroxyfm of periodic or convnlfive afthma is preceded very generally by dyfpepfia, and the circumftances which occur to a re¬ laxed habit. This condition of the body may have pre¬ vailed for months or years before it takes the additional form of afthma; but, when that difeafe appears, dyfpep- iia never fails to be aggravated, and to lhow itfelf with violence before the lit. “ The firft fymptoms are flatulence and diftention of the ftomach and bowels; a heavy pain over the forehead and eyes ; eruCtation of wind, with water which is fometimes infipid, at others four. When the evening approaches, this weight over the eyes becomes more oppreflive, and the patient is very fleepy. Occafionally, if he be particu¬ larly animated by company and conversation, the drow- finefs does not take place, but a fhortnefs of breathing is perceived, and foon after much anxiety of the prascor- dia, with great reftleflnefs. The prefence of company then becomes irkfome, as it feems to increafe a certain heat of the body, a want of free refpiration, and an irri¬ tability which repels the moll cautious attentions of friends. Frequently at this period there is a tingling and heat in the ears, neck, and breaft, and a motion to expel the contents of the bowels is attempted with fome violence, and with great uneafinefs of the abdominal mufcles. When an afthmatic feels thefe warnings, he may be convinced that his enemy is at hand. At fome uncertain hour before midnight the patient becomes Suddenly fenflble of the increafed violence of the difor- der ; moft frequently after a dumber in bed he awakes with:great difficulty of breathing, and he feels the ne- ceflity of a more ereCt pofture of his body. Infpiration is performed with great effort of the mufcles, but is never perfe&ly deep, and the diaphragm feems to defcend with great difficulty againft an oppofing force. There is now a defire of free air, fpeaking becomes diftrefling, and the irritability of the mind continues, but is not lb acute as in the approach of the fit. There is a great ftraitnefs of the cheft, and a wheezing found in refpiration. An inclination to cough Ihows itfelf, but this is Small and in¬ terrupted. The pulfe is increafed in quicknefs a few ffrokes, but without hardnefs. There is no preternatu¬ ral thirft, unlefs, as often happens, the fit be excited by indigeftible matter in the firft paffages. There is a pro¬ pensity to make water, which is copious and pale, and frequently discharged. After fome hours of diftrefs the patient perceives his anxiety to be lefs, the breathing is lefs quick and laborious, the inspirations are longer and more full, the expirations are ftill attended with wheez¬ ing; the pulfe is not So quick, but more full; irritation is lefs acute. The cough probably brings up a portion of phlegm, and a very fenflble relief follows that excre¬ tion. Then the tranquil ftate of the feelings introduces fleep, but not unaccompanied by wheezing, which con¬ tinues almoft always through the firft night, and until, by the progrefs of the fit on the fecond or third day, a more considerable expectoration of mucus takes place. “The fecond day is ufhered in by a remiflion of the fymptoms, which the patient perceives from the time of awaking in the morning. No change of pofture is, how¬ ever, yet made with impunity; and particular diftrefs af- feCts him, if he engage in the fatigue of drefling whilft the ftomach is empty. The pulfe will be accelerated more than it was in the acme of the paroxyfm ; and mo¬ tion muff: frequently be fufpended, or a vehement agony for breath will certainly come on. During the day, if no particular hurry occur, the breathing becomes gra¬ dually more free till the evening ; an inexperienced afth¬ matic even flatters himfelf that his difeafe is leavinghim, but lie finds at the approach of night that he mult fuf- tain a new attack. The par.oxyfm recommences with the ufual fymptoms, and the night is palled nearly as the VOL. XIX, No. izy6. 137 former; but the fleep is more perfect, and produ&ive of more relief. “ The third day, the remiflion is more complete; there is fome additional expectoration ; and bodily motion is performed with lefs diftrefs, but ftill with great incon¬ venience. After the paroxyfm has been renewed in this manner for three nights, the expectoration generally be¬ comes free, but there is no certain termination of the fit at a fixed period. However, except in particular cafes, it goes off after a few days ; and, as the daily re- mifllons become more perfeCt, the urine is higher co¬ loured, and in fmaller quantities; the expectorated mu¬ cus is more copious and digefted ; ftrength of pulfe and vigour of aCtion increafe, and good humour again enli¬ vens the mind. “ The expectorated mucus has been faid to be ftreaked with black, or to have a blackilh tinge ; and this appear¬ ance certainly prevails in many inltances, but not inva¬ riably. The tafte of the expectorated mucus is alfo equally uncertain; it is fometimes fweetilh, but more frequently it is faline, and it is occafionally coloured mi¬ nutely with blood. There is a confiderable variation in the periods of the accefiion of the paroxyfm, and in its duration, in the intervals of the fits, the quantity of mucus expectorated, and the freedom of that difcharge. Thefe circumftances of the difeafe will be influenced by the predifpofing caufes, and by occafional accidents.” Dr. Bree’s Practical Inquiry into Difordered Refpiration. Afthma may occur at any age ; but except where there is a mal-conformation of the cheft, it feldom attacks in early life. It ufually afflicts perfons of mature or ad¬ vanced age. People who follow certain occupations are more liable to it than others ; fuch as millers, maltfters, ftone-cutters, wool-combers, flax-drefl'ers, &c. Many of thefe inltances, however, of Ihort breathing, belong rather to Dyfpncea than to Afthma. Although the attacks are fo fevere and diftrefling for the time, yet in the intervals the patient commonly enjoys a tolerable fhare of health, and is able to engage in the purfuits of bufinefs or plea- fure, according to his ftation in life ; nor do they feem, in numerous inltances, to have much effeCt in Ihortening the natural period of human exiftence, many allhmatics having been known to live to the age of feventyand up¬ wards. The difeafe, however, terminates at length in peripneumony, confumption, dropfy, lethargy, or apo¬ plexy. In the treatment of afthma, we have two purpofes to effeCt ; viz. to relieve the paroxyfm on the one hand, and to reCtify the morbid condition of the pulmonary organs on the other. We have feen that the paroxyfm is moft frequently excited by diftention of the ftomach and bowels, or by the accumulation of irritating fecretion in the bronchial tubes. Hence we mult labour to evacuate the offending matter from each cavity ; we mult further allay, by anti- fpafmodic medicines, the irregular aCtion of the mufcu- lar parts. An emetic is the firft remedy to be applied. By gentle vomiting we may obtain fome knowledge of the ftate of the firft paflages; and the paroxyfm will go on with milder exacerbations, if irritating matter be re¬ moved from thfe ftomach and duodenum. Further than this, naufea and vomiting difcharge the fubtil and Acrid particles which have been received in infpiration, by pro¬ moting fuch a fecretion of lymph as may envelope them, and excite expectoration ; befides which, this dilution probably defends the membrane from further irritation. Afterwards a draught with one ounce of diftilled vinegar, and from one to three grains of pulv. ipecac, in pure wa¬ ter, may be taken every four hours, as a means of deter¬ mining to the furface of the body, and promoting abforp- tion and exhalation. If coftivenefs prevail, it will be neceflary to remove it, by the ufe of rhubarb or infufion of fenna; but we mult avoid full purging. If acid eruc¬ tations are frequent, then, inftead of the acetous draughts with ipecac, chalk or magnefia ufta in a draught 3 C of 188 PATHO of mint-water, with the fame naufeating ingredient, will anfwer better. Dr. Bree ftates, that “ it has happened in feveral inftances, after various means intended to miti¬ gate the diftrefs of the fit had failed, that the Rubigo ferri, or carbonate of iron, in dofes of ten grains every four hours, appeared mod clearly to remove the pa- roxyfm.” This effeft can only, he thinks, be accounted for by looking to the inert condition of the ftomach and lungs, and to the languid ftate of the circulation in the thoracic and abdominal vifcera. He adds, “ Whatever in fuch circumftances can haften the paflage of the blood through the lungs, and promote a quicker return to the heart from the lower vifcera^ mild be ufeful in the inten¬ tion of prefent relief, as well as of aftual cure.” It is in aid of this acceleration of blood to the lungs that ih- haling oxygen, as recomme'nded by Dr. Beddoes, is an ufeful meafure. See 'lherapcutics in this article. “ In the morning, the patient fhould take clear coffee as foon as he awakes, which fhould be repeated at inter¬ vals with dry toaft; and this drink, which feems to aft medicinally on afthrna, may be adminiftered, during the remifiion alfo, with a few drops of tinft. opii, every three hours, the naufeating draught being fufpended between the exacerbations. At the beginning of the fecond exa¬ cerbation the naufeating draught fhould be repeated, at firft with a fufficient proportion of ipecacuhan to excite puking, and afterwards with a lefs dofe that may only oc- cafion naufea. In the fecond remifiion, the plan purfued in the former fhould be refumed. The third exacerba¬ tion will probably be mild, fo that the ipecacuhan draughts may be fufpended, or they may be united with aether and tinfture of columbo in place of the ipecacu¬ han. With this plan there will appear on the third day a confiderable tendency to expeftorate, which fhould be promoted by ammoniac, and vinegar of fquill with tinft. opii, or with volatile falts. Ammoniac is called an ex- peftorant; but the patient, before this period, too fre¬ quently takes this naufeous medicine without ufe.” Bree, p. 283. 5th edit. From this time we have to turn our attention to the cure of the complaint during its remifiion; and what can be effefted for this purpofe may be ftated in a very few words. It is fcarcely neceffary to mention the removal of the exciting caufe. If bad air, a removal to a better fituation; if gaftric or inteftinal difturbance, (no doubt the primary caufe in the major proportion of cafes,) a rigid adoption of the treatment of Dyfpepfia (which fee) muft be followed. We may remark here, that, having fully entered into the coniideration of diet, &c. under that head, we fliall feel it unneceffary to refume the fub- jeft in our account of every one of thofe dileafes to which fimilar regulations are applicable. In afthrna thefe regulations fhould be fulfilled with much diligence and attention; but they will always re¬ quire accommodation to individual cafes, particularly to patients with nervous ailments. We may remark, that cordial and ftimulating bitters are particularly indi¬ cated in afthrna. Thefe remedies will require a long con¬ tinuance in their ufe, and frequent change of the varie¬ ties. With regard to the management of the fanguineous fyftem in this complaint, it is to be borne in mind, that a great number of cafes are on record in which it wascon- nefted with organic changes in the thoracic vifcera. To prevent therefore fuch occurrences, it is of importance that we by no means negleft to moderate the force of the circulating powers. In eftefting this purpofe, we muft be guided by the pulfe, with little reference to the nofological divifion of difeafe. Unlefs from the above confideration, bleeding fhould be cautioufly reforted to. Dr. Bree ftates, that, “ under confiderable evacuations of blood, the fudden depletion of the veflels may leave their coats without the ftimulus receffary to produce a contraftion equal to the fpace LOGY. which the blood had occupied ; the heart will participate in the injury, and will alfo be deficient in vigour of con¬ traftion. If, therefore, blood be taken, it fhould be drawn from the veflels at intervals, and in fmall portions, which would allow of a contraftiie power being exerted, in proportion as the vefiel lofes its contents; and fo much fluid would not finally be taken away as to leave it with¬ out the ftimulus of diftention, fo eflential to its returp of health.” He fays alfo, that, “ before the pulmonary veflels have relieved themfelves by their exhaling orifices, blood may pofiibly be drawn with fome advantage; but, when effufion has taken place, a certain debility follows, and a lofs of contraftiie power in the veflels.” The fame purpofe is alfo effefted by digitalis, though the good effeft of this remedy is atterted by fome in cafes where no extraordinary degree of pulfation was manifeft in the arteries. The aftion of this remedy is by no means well underftood. It is of much importance to excite the minute parts of the circulatory fyftem, for the purpofe of unloading the great veflels. From what we obferve in other complaints, we fhould be inclined to ufe the warm bath ; but Dr. Bree reports unfavourably of it : it feemed, in this one cafe efpecially, to aggravate the ma¬ lady. Of the cold bath this author, in common with many others, fpeaks favourably. The firft effeft of the bath feems to be painful and injurious: but, when re-ac¬ tion follows, (and it fhould only be ufed when this does follow,) the cutaneous capillaries are excited, and thus unload the circulation ; independently of which, they communicate a fympathetic vigour to the pulmonary ex- halants. The tendency to fpitting fhould be promoted by the exhibition of expectorating medicines ; fuch as ipecacu¬ anha, oxymel of fquill, and ammoniacum. Of the firft of thefe, not more than two or three grains fhould be gi ven for a dofe, fo as to excite, in this ftage of the diforder, merely naufea, but not vomiting; the two others fhould be joined together in the form of a draught or mixture, with or without the addition of tether. A dry and pure air, but not that of an elevated fitua- tion, is in general belt fuited to afthmatics ; there are, however, as before ftated, frequent exceptions to this ob- fervation. The bowels fhould be kept regular, by rhu¬ barb and aloetic aperients. Small dofes of calomel may be given with great advantage, in many cafes; and efpe¬ cially where the afthmatic affeftion is connefted with a difeafe of the fkin. Whenever the patient’s feelings warn. him of an approaching attack, he fhould take an emetic, and after its operation an opiate : and at all times he fhould encourage expeftoration ; but oleaginous emul- fions and fweet mixtures fhould be profcribed. Ifl’ues have been recommended by fome praftitioners for lef- fening the frequency and violence of the paroxyfms. It is faid that king William continued perfeftly free from his afthmatic complaint, during the whole of the time that the wound he received on his fhoulder, in the battle of the Boyne, kept open and difcharged matter. The utility of counter-irritants feems here very equi¬ vocal, efpecially in young fubjefts. Dr. Bree fays, “ In very old afthmatics, ifiues are fometimes necef- fary. In younger fubjefts, when the difeafe is not yet inveterate, they may occafionally be ufeful, by diverting aqueous humour from the lungs, and giving a better op¬ portunity for the operation of tonic remedies.” Diuretics have been very generally reforted to, often perhaps becaufe in this complaint the urinary fecretion is difordered ; but this is generally traceable to the dyf- peptic fymptoms to which our attention fhould be prin¬ cipally direfted. There are cafes, however, in which diu¬ retics are plainly indicated. When Dyfpncea remains after the fit, and the urine is at the fame time fmall in quantity, and high coloured, faline diuretics fhould be given; and mercurials are alfo then ufefully com¬ bined, as the cafe is probabiy complicated with vifceral obftruftions. PATHOLOGY. 189 obftruflions. Diaphoretics are of much ufe in the ear¬ lier ftages of afthma ; but, when the malady is of long Handing, their utility is often doubtful. Whenever they are employed, gentle perforation, not fweating, fliould be elicited. Stimulating ludorifics are for the moll part improper. The pulv. ipecac, comp, will be found a ufe- ful diaphoretic in afthma. It is generally allowed to be a very innocent form of exhibiting opium ; and the ufe of this article is often called for by the deranged Hate of the nerves, as much as the aftion of the fkin is required to be promoted by its diaphoretic property. The inhalation of fteam ariling from various herbs, as hemlock, ftramo- nium, &c. appears to be rather hurtful. Indeed from what has been before faid of the caufe of afthma, it is evident, that heat and moifture conveyed into the lungs is by no means likely to cure an afthma. A regular ufe of oxygen between the paroxyfms, and when inflamma¬ tory tendency exifts, will be found more ufefu). 2. Afthma humidum, humoral afthma. Under this term fome phyficians have comprehended the anafarca of the lungs j but we defignate by it that fpecies or variety of fhortnefs of breath or wheezing, which is accompanied with a conllant cough, and expectoration of mucus, and which is diftinguilhed from phthifisand catarrh by being unattended with fever. It is diftinguilhed fromadropfy of the cheft, by the abfence of a numbnefs of the arms, and (after the ceflation of a temporary aggravation of the fliort-breathing from accidental caufes) by the patient being able to bear the horizontal pollute. It is the pi- luitous afthma of fome writers. It generally begins un¬ der the form of the firft fpecies, or convullive afthma $ and, like it, is liable to accidental aggravations from changes of the weather, and the other exciting caufes before mentioned. In regard to its therapeutical treat¬ ment, we Ihould adminiller emetics anti expeflorants joined with artherand other antifpafmodics. Bliftersand ilfues are more ferviceable here than in the convulfive afthma; but the employment of diuretics is more parti¬ cularly indicated ; fuch as fquill, acetated kali, and di¬ gitalis. Ten or fifteen drops of the tinClure of foxglove, or one grain or a grain and a half of the powdered leaves, joined with a fourth part of opium, Ihould be given at a dofe, and repeated twice in twelve or fourteen hours, until the fhortnefs of the breath is relieved by a flow of urine, or until fuch an eft'efl is produced on the pulfe, the head, or the bowels, as fliall make it neceflary to fuf- pend the ufe of the medicine. Decoflions of feneka or dulcamara (fee Practical Synopfis of the Materia Medica, vol. i. p. 152, 233.) may be prefcribed in place of the digitalis, where this laft fliall be found to difagree. The patient fliould be direfled to wear flannel next his Ikin, and to keep his feet warm and dry. It is worthy of remark, that afthma is often prolonged by the habitual ill-aflion of the refpiratory mufcles, their nerves, or the bronchial exhalants, when the general health is otherwife tolerably good, and the patient free from the external agents which firft: caufed the malady. When the difeafe affumes this form, the paroxyfm js lia¬ ble to be brought on by mental emotion, or any extraor¬ dinary impulfe on the nervous fyllem. As the aftion of mufcles in general, by frequent repetition, produces in them a great mobility, orpronenefs to contradl, fo thole of the glottis and chelt equally obey this law. It is to the mufcles therefore that Dr. Bree referred the feat of this afthma from habit. Others deem it a want of energy in the nerves; and this feems a very probable account of it in fome cafes. The complaint is to be cured by tliofe meafures likely to break the aflociated chain of morbid adlions ; as, em¬ ployment of an interefting kind when the paroxyfm is flightly threatened ; a complete change of air and occu¬ pation, a ufe of ftimulants of higher order than is admif- fible in the preceding forms of afthma, tolerably good jiving, and aflive exercife. But galvanifm is a remedy of the firft importance. Dr. W. Philip having ufed this meafure with great fuccefs, we quote his account of its adminiftration. “ I have employed galvanifm in many cafes of habit¬ ual afthma, and almoft uniformly with relief ; and have found the aftedlion of the breathing as readily relieved when it appeared as a primary difeafe, as when it fuc- ceeded to indigeftion. The time, during which the galva¬ nifm was applied before the patient faid that his breathing was eafy, has varied from five minutes to a quarter of an hour. I fpeak of its application in as great a degree as the patient could bear without complaint. For this ef¬ fect I latterly found from eight to fixteen four-inch plates of zinc and copper, the fluid employed being one part of muriatic acid, and a hundred and twenty of water, fuf- ficient. Some require more than fixteen plates, and a few cannot bear fo many as eight; for the fenfibility of dif¬ ferent individuals to galvanifm is very different. It is curious, and not eafily accounted for, that a conliderable power, that perhaps of twenty- five or thirty plates, is often neceflary, on firll applying the galvanifm, in order to excite any fenfation ; yet, after the fenfation is once excited, the patient fhall not, perhaps, particularly at firft, be able to bear more than fix or eight plates. The ftronger the fenfation excited, the more fpeedy in gene¬ ral is the relief. I have known the breathing inftantly relieved by a very ftrong power. It has generally been made a rule to begin with a very weak one, and increafe it gradually at the patient’s requeft, by moving one .of the wires from one divifion of the trough to another, and moving it back again when he complained of the fenfation being too ftrong. It is convenient for this pur- pofe to charge with the fluid about thirty plates. “ The galvanifm was applied in the following manner. Two thin plates of metal, about two or three inches in diameter, dipped in water, were applied, one to the nape of the neck, the other to the lower part of the epigaf- tric region. The wires, from the different ends of the trough, were brought into contact with thefe plates, and, as obferved above, as great a galvanic power maintained as the patient could bear without complaint. In this way the galvanic influence was fent through the lungs, as much as poflible, in the direction of their nerves. It is proper, conftantly to move the wires Upon the metal plates, particularly the negative wire, otherwife the cu¬ ticle is injured in the places on which they reft. The relief feemed much the fame, whether the pofitive wire was applied to the nape of the neck, or the pit of the llo- macln The negative wire generally excites the ftrongefl fenfation. Some patients thought thatthe relief was molt fpeedy, when it was applied to the epigaftric region. The galvanifm was difcontinued as foon as the patient faid that his breathing was eafy. In the firft cafes in which I ufed it, I fometimes prolonged its application for a quarter of an hour or twenty minutes after the pa¬ tient faid he was perfeflly relieved, in the hope of pre¬ venting the early recurrence of the dyfpnoea ; but I did not find that it had this eft'efl-. It is remarkable, that, in feveral who had laboured under opprefled breathing for from ten to twenty years, it gave relief quite as rea¬ dily as in more recent cafes; which proves, that this ha¬ bitual difficulty of breathing, even in the moll protrafled cafes, is not (always) afcribabie to any change having taken place in the more evident mechanifin of the lungs.” Philip on Indigeftion, p. 372. Genus IV. EphiaUes, [Gr. a leaper, becaufe it was thought a demon ‘'leaped” upon the bread.] Incubus, or Nightmare. Generic characters — Sighing fuffocative anhelation, with intercepted utterance, and a fenie of fome external fubftance prefling heavily on the chelt: tran- fitory. This genus has two Ipecies, both of which are fomewhat allied to epilepfy. 1. F.phialtes vigilantium : produced during wakeful- nefs 5 190 PATHOLOGY. nefs ; the preffure fevere, and extending over the abdo¬ men; refpiratioii frequent, laborious conltridted; eyes fixed; fighing deep and violent; intellect undifturbed. E. vigilantium is entered on the authority of Rhodius and Sauvages. Sauvages gives us three other fpecies, but thefe are evidently fymptomatic of other affe£tions. It is a difeafe rarely met with, and generally arifing from fevere irritation of the nerves of the ftomach. a. Ephialtes nofturnus, (Oneirodynia gravans, Cullen.') ■Nightmare, or elf-fquatting : produced during deep, and interrupting it with violent ftruggle and tremor; the preffure on the cheft feeming to be that of fome hideous monfter or phantom. This latter fympfom has given rife to the various popular names, wdiich, however differ¬ ent in different countries, all agree in exprefling the pre¬ fence of fome phantom, wizard, or goblin ; and which, as Dry den fays, Seeks fome love- wiider’d maid with fleep opprefs’d. Alights, and grinning fits upon her brealt. Befides the delufion of fupernatural fpirits, the imagi¬ nation at times difplays the calamities of life. The patient fancies himfelf to be ftruggling with flrong men, or to be in a houfe on fire, or in danger of being drowned; and, in attempting to run away from danger, or climb up a hill, he fancies he falls back as much after every ftep as he had advanced before. After he awakes, the terror excited by thefe frightful ideas leaves often a palpitation of the heart, with great anxiety and languor, and fometimes a tingling of the ears, and a general tremor. Many abfurd explanations have been given ofthe phenome¬ non of incubus, which we fhall not flop to detail. It is now generally agreed that the feat of the nightmare is principally in the ftomach. It is well afcertained that fome forms of epilepfy, and of hyfterical fits, originate from diforder in that vifcus ; and fo great a fimilarity exifts between the difeafes, that Galen confidered the in¬ cubus as a nocturnal or flight epilepfy. People troubled with nervous and hypochondriac affeftions, and who have delicate or flatulent ftomachs, are more peculiarly fubjeft to this diforder ; and it is obferved, that a heavy or flatulent fupper greatly aggravates the nightmare in thofe who are predifpofed to it. The fympathy of the ftomach with the head, heart, lungs, and diaphragm, is fo remarkable, that there can be no difficulty in referring the feveral fymptoms of the incubus to a difagreeable ir¬ ritation of the nerves of the ftomach. The incubus is moft apt to feize perfons when lying on their back, becaufe, in this pofition, on account of the ftomach and other abdominal vifcera prefling more upon the diaphragm, we cannot infpire with the fame eafe as when we fit up or lie on one fide. Further, in that fitua- tion of the body the food feems to lie heavier on the fto- mach, and wind in it does not feparate fo readily by the cefophagus and pylorus as in an ereft pofture, when thefe orifices are higher than the other parts of the ftomach. The nightmare occurs in the time of fleep, becaufe the ftrange ideas excited in the mind, in confequence ofthe difordered feelings of the ftomach, are not then correfited by the external fenfes as they are when w'e are awake ; nor do we, by an increafed refpiration or other motions of the body, endeavour to (bake off any beginning uneafy fenfation about the ftomach or breaft. The incubus ge¬ nerally occurs in thefirft fleep, and feldom towards mor¬ ning, becaufe at the earlier period the ftomach is more loaded with food, and thatin a more crudeand indigefted ftate than in the morning. A lefs degree, amounting only to frightful dreams, is almoft a conftant concomi¬ tant of overloaded ftomach in fome habits; and requires the fame treatment as Dyfpepfia, which fee. Genus V. Sternalgia, [from npvov, the breaft-bone, and pain.] Violent pain about the fternum, extending towards the arms ; anxiety, difficulty of breathing, and fenfe of fuftocation. (Angina pe&oris, Iieberden and Cullen.) Our nofologifts have given us two fpecies ; but we are notfatisfied with their reafons for the diftinftion. They are, 1. Sternalgia ambulantium, (Afthma artliriticum, Schmidt. Diaphragmatic gout, Butler.) Supervening fuddenly during exercife ; with tendency to fyncope ; relieved by reft. 2. Sternalgia chronica. (Orthopnoea cardiaca, Sa ire. Syncope anginofa, Duncan and Barry.) The paroxyfms lefs violent, but of longer continuance; recurring fre¬ quently with great palpitation of the heart, excited by flight, and often unknown, caufes ; and not relieved by reft. This dreadful diforder is found to attack men much more frequently than women, particularly thofe who have fliort necks, and are plethoric or corpulent. Al¬ though it is fometimes met with in perfons under the age of twenty, it more frequently occurs in thofe who are between forty and fifty. In flight cafes, and in the firlt ftage of the diforder, the fit comes on by going up¬ hill, up-ftairs, or by walking at a quick pace after a hearty meal; but as the difeafe advances, or becomes more violent, the paroxyfms are eafily excited by paflions of the mind ; by exercife even of the moderate kind ; by fneezing, coughing, or {training at {tool. In fome cafes, the patient is attacked whilft fitting or (landing, without any previous exertion or obvious caufe. On a fudden, he is feized with an acute pain or tightnefs at the extre¬ mity ofthe fternum, inclining to the left fide, and ex¬ tending up into the arm, as far as the infertion of the deltoid mufcle, accompanied by a fenfe of fuftocation, great anxiety, and a dreadful conviction of the fatal tendency of this malady. This commonly continues for the (pace of an hour. In the firft ftage of the difeafe, the uneafy fenfation at the end of the fternum, with the other unpleafant fymp¬ toms, which feemed to threaten a fufpenfion of life by a perfeverance in exertion, ufually go off7 upon the perfon's (landing (till, or turning from the wind. Dr. Parry dates, that bending the body in fome cafes increafes the pain ; and therefore the patient draws himfelf up ftraight, with the head fomewhat bent backwards. In a more advanced ftage, the paroxyfms do not fo readily recede, and are much more violent. During the fit, the pulfe finks in a greater or lefs degree, and be¬ comes irregular ; the face and extremities are pale, and bathed in a cold fweat ; and, for a while, the patient is perhaps deprived of the powers of fenfe and voluntary motion. People affeCted with this complaint often die fuddenly, but fome continue fubjeCt to it for upwards of twenty years. The caufe of this diftrefling malady is not clearly un- derftood ; it was formerly fuppofed to be either a fpaf- modic affeCtion, or a caries of the fternum; after this, Dr. Parry dated that it was an oflification of the coronary ar¬ teries which fupply the mufcular fubftance of the heart with blood. This change of (truCture mull certainly render the heart unequal to the talk of circulating the unufual quantity of blood thrown upon it by bodily ex¬ ertions or paflions of the mind; and, as the oflification increafes, it muft at all times impede the circulation. Dr. Parry fupports this notion by diffeCtions ; but it is clear that Angina peCtoris often occurs and amends fpon- taneoufly, or is removed by medicines ; a confummation not poflible if the coronary arteries were oflified. Dr. Reeder, in his work on the Difeafes of the Heart, divides the caufes of Sternalgia into four claffes. i. An oflified, or otherwife difeafed, ftate of the coronary arte¬ ries, whereby their calibre becomes much diminiflied ; or an oflified condition of that portion of the aorta whereat thefe veflels are given off-, fo as to.leffen the diameter of their aortal orifices. 2. Oflification and enlargement of the valves of the heart, and of thofe placed at the origin of the aorta and pulmonary artery ; alfo morbid contrac¬ tion of the different apertures to which they are attached ; 3 P A T H O and enlargement of the heart accompanying thefe morbid Hates. 3. Aneurifm and edification of the thoracic por¬ tion of the aorta. 4. A difordered date of the chylopoietic organs, more efpecially of the ftomach, producing indi- gellion. When Sternalgia arifes from organic derangement, it admits only of palliation ; and, when fympathetic only, the difeafe producing the fympathetic manifeftation fhould be removed. On this account, to diftinguifh be¬ tween the two caufes is of the utmoft confequence. Dr. Powell, in the Tranfaftions of the College of Phyficians, thus details the diftingui filing, fymptoms : “ When a patient complains of a flight difficulty in refpiration, increafed by exercife, and aggravated by a recum¬ bent pofture ; if the pulfe does not beat with intermiffions, and the feveral ftrokes are not unequal in force, although the pulfations may be preternatural ly flow, or, on the contrary, more than ufually quick, I know, from aftual examination after death under thefe different circum- ftances, that there fometimes is not any organic difeafe in the thorax. If refpiration be uneafy, and the patient, at firft experiencing fome difficulty in lying down, (hall in a little while fo adjuft his pofition as to deep comfor¬ tably, I believe there cannot be any organic mifehief in the thorax, although poflibly there may be effufion. If the patient cannot fleep in a recumbent pofture, or, when afleep, if, Aiding down gradually into his bed, he is fud- denly awaked with a fenfe of fpafmodic ftri&ure and ftrangulation, provided there hath not been previoufly obferved an irregular and an intermittent pulfe, I fhould fufpeft effufion within the cheft, rather than any difeafe of ft ru flu re. And if, in addition to the above circum- ftances, there fhould be anafarcous fwellings of the legs, and the countenance fhould be bloated and purple-co¬ loured, the cheft is certainly labouring under an effufion of fluid ; but even then it is not abfolutely clear that hy¬ drothorax is actually produced by mal- organization in the thoracic vifeera.” Dr. Hutchinfon, the late editor of the London Me¬ dical journal, has remarked the Angular and charaffer- iftic fymptoms of fwelling of the throat, painful deglu¬ tition, and hoarfenefs, as attendant difeafes of the heart which exhibit the form of Angina peftoris. None of the diagnoftics are however infallible 5 and indeed the dif- tindfion between nervous and organic difeafes of the thorax is one of the greateft difficulties in the whole lift of human maladies. In the treatment of Angina, we have to confider its palliation during the paroxyfm, and its effectual remo¬ val. Antifpafmodics are the ufual agents employed for the former purpofe. Dr. Reeder, in his treatife quoted before, objefts to the life of internal ftimuli, unlefs the heart appear unable, after the lapfe of fome time, to re¬ gain its ufual adlion, when weak wine and water, a fmall quantity of aether or fpirit of ammonia diluted, may be given. Some patients experience immediate relief by Itrong brandy and water. Should not thefe fucceed, we fhould apply a blifter over the cardiac region, and im- merfe the arm, when much affedled, in hot water, and afterwards diredl it to be rubbed with fome ftiniulant and anodyne liniment. Opium may be given with advantage in a protrafted paroxyfm ; and this medicine, or the ex- trafl of hyofeiamus, often prevents no&umal attacks, when given at bed-time. Should the fyncope remain an undue length of time, it will be neceffary to tranfmit elec¬ tric or galvanic ffiocks through the region of the heart, and to inflate the lungs by proper bellows, fo as to elta- blifti an artificial pulmonary and aortal circulation. _ A few drops of hydrocyanic acid have been faid to re¬ lieve the paroxyfm of Sternalgia very rapidly. In the intervals between the paroxylms, much may be effected to prevent their acceflion, by the patient obferving pro¬ per rules with refpeft to exercife and diet, and by avoid¬ ing exciting caufes. Exercife, particularly on horfeback, liquid not be had recourfe to when the ftomach is full. You. XIX. No. 1297. LOGY. 191 Dr. R. advifes his patients to drink water, and to eat fparingly ; to keep the bowels open ; to regulate the temperature of the body by clothing, and to avoid heated rooms and an impure atmofphere. Occafional plethora fhould be removed by bleeding in the recumbent pofition, or by cupping ; and its recurrence prevented as much as poffibie by the almoft exclufive ufe of farina¬ ceous food. I flues in the thighs or arms may be ufed, as well as the tartrite of antimony, to excite a puftular eruption ; but an occafional blifter will generally anfwer every purpofe, with much lefs inconvenience to the pa¬ tient. Genus VL Pteuralgia, [wAeup, the fide, and <*Ayo?, pain.] Sharp pain, or ftitch, in the fide; difficulty of breathing, without fever or inflammation j and thus dif- tinguiflied from Pleuritis, or pleurify. A ftitch or pain in the fide often occurs, independent¬ ly of any acute inflammation of the lungs, pleura, or con¬ tiguous organs, and it is generally increafed by the ac¬ tion of breathing. It has been often denominated a falfe or fpurious pleurify. The pain, however, is feldom feated in the membrane called the pleura, but often in the mufcles of the cheft, fometimes in the other membra¬ nous parts ; and it may arife from rheumatifm affecting thofe parts, from fpafm or cramp, from a plethoric con¬ dition, or from a nervous and hyfterical ftate, in which the circulation is languid and irregular : it may alfo be connected with a gouty, fiphilitic, or fcorbutic, habit. Sauvages has diftributed the PI eurodyne (his name for this genus) into eighteen fpecies, according to itsorigin from one or other of thefe caufes. But Dr. Good gives us only two fpecies. 1. Pleuralgia acuta: fudden and temporary; fuper- vening on mufcular exercife; relieved by preffure. 2. Chronica: permanent: augmented by preffure 5 in¬ ability of lying on the tide affedted. The firft fpecies found alio frequently as a fymptom in flatulence, hyfteria, and hypochondriafts. The fecond in plethora, worms, fiphilis, phthifis, rickets, catarrh, and rheumatifm. See Pleuritis. Class III. HAEMATIC A, [from the Gr. «-i blood.] Diseases of the Sanguineous Function. The chief modes in which the fanguineous fyftem is influenced in difeafe is in regard to the ftate of the con¬ tained fluid on the one hand, or the ftate of the con¬ taining veflfels on the other. The confideration of the firft occupied, as is well known, for a long time, the medical world ; and the inoft famous hypothefes of the feventeenth and early part of the eighteenth centuries were founded on fuppofed chemical changes in the blood during difeafed ftates. (See the hiftorical feftion of this article, p. 13' — 16.) At prefent, though it is acknow¬ ledged that the contained fluids vary much as to their nature in different perfons and difeafes, and that the in¬ troduction of foreign bodies in an unajfimilated ftate is followed by. violent fymptoms, yet we have alfo afeer- tained that the conftitution accommodates itfelf in a great degree to thofe infeniible changes which unufual food or indigeftion produces, and that the blood exhibits a variety in the proportion of its conftituent parts even in healthy individuals. There can be no doubt that a ge¬ neral bad ftate of the fluid of the body exifts in fome difeafes ; and thefe are neceflarily accompanied with alteration in the contraftile power of the blood-veffels. Of the nature, however, of this morbid alteration of the blood, we know fcarcejy any thing. We ftiall mention the fcaqty flock of fads we are furniffied with on this fubjefit when treating of the laft order of this clafs, Dyjpeptica, or Cachexies. The quantity of the blood in the animal frame varies in moft difeafes, and often without our being able to trace any very manifeft caufes. of this Variation. Some 3 D diftinguilhed PATHOLOGY. 192 diftinguiflied authors have adduced the faCtof general inor¬ dinate habits of eating as an explanation of the frequency of plethora; but as, from the fails we have noticed under Dyfpepfm it is clear that gluttony mud lead for the moll part to indigeftion, and that to deficient nutrition we fhould be tempted to look for the caufe of this Hate. In the general diminution of fecretion, and in fail in fevers where this diminution is very apparent, a full Hate of the blood-veli'els is the moft formidable fymptom, and one which the moll copious abftraCtion of blood in many cafes fcarcely abates. The plethoric Hate may (though it rarely does) exilt in the fame degree in the fanguineous fyftem generally ; or it may be exceffive in all parts, but much more fo in one or more peculiar ftruCtures ; or, which is more com¬ mon, it may be exceflive in one part, and deficient in the reft. Under each of thefe circumllances, the blood-vef- fels are dillurbed in their functions; which brings us to the confideration of thefe latter parts. At page 28, we have detailed briefly the agents of the circulation, and have not hefitated to mention the con¬ tractility of arteries as one of them. In doing this, however, we were perfectly aware, that we were oppofed by the opinions and experiments of fome of our bell pathologills ; yet, on the other handymen of equal ta¬ lent, and the authors of experiments apparently con¬ ducted with equal precifion, fcrongly corroborate our view of the queltion. For our own parts, we pay little deference to thefe experiments which, from their very nature, can never be conclulive. Whoever will take the trouble to read over with attention the numerous hifto- ries of experiments detailed by Dr. Haltings, the lad au¬ thor who has performed experiments on this fubjeCl, will concur with us in this opinion. They will find, that in fome experiments the dilatation and contraction was not manifeft at all; in others, not for fome time; and in others immediately and unequivocally. Indeed we fhould naturally expeCt that thefe circumllances would occur to parts llimulated by unnatural means; and de¬ prived no doubt of much of the fluid of the vafa vacofum by the difleCtion necefl'ary for their expolure. We think, however, that this matter may be more fa- tisfaCtorily fettled by analogical reafoning than by the evidence of the fenfes, when that evidence produces fuch various appearances. By thofe who fuppofe that arteries aid the motion of the blood, it has been afierted, that the heart cannot propel that fluid through the round of the circulation ; but this afl'ertion has neither been proved nor difproved. One party fays that the heart has this power, for this reafon ; it is not required to drive the blood through the whole of the arterial and venous fyftems, fince an impreflion on the aorta by means of the left ventricle (the column ofblood being continuous) mult immediately, and without the hindrance of friction, be tranfmitted to that portion which the venous fyltem is pouring into the oppolite fide of the heart. But it is certain that this continuous column is liable to much variation; and hence it would feem more probable that the arteries lent fome aflillance to the heart. That the arteries have this power in fome animals is demonllrated, becaufe they have no heart ; and, though Dr. Parry may fay, that “ if the circulation is carried on by any central force of whatever defcription, the apparatus in which that force refides is to all intents and purpofes a heart he mull in this cafe lhow how the ftruCture in queltion differs from arteries in common ; and that it does differ, the refearches of the accurate Sir Everard Home feein to deny. It might appear, that the dependence fome arteries have on the nervous fyftem, and that exclufively of the heart, was a ftrong argument in favour of the con¬ tractility of thefe veflels; but thofe who difcredit the exiltence of this property aflert, that this independent aCtion of the artery arifes from the debility of its pa- rietes, which gives way to the impulfe of the heart, and admits a greater flow of blood ; this debility exprefling, according to them, a lofs of tonicity, or that degree of contraction which an artery is at all times exerting on its contents. WTe cannot help thinking that the truth of this refo- lutely-contefted point lies between. For, upon examin¬ ing the probable aCtion of tonicity, little difference will be feen between it and the phenomena of contractility. We mult remark, that tonicity is uled by one party to denominate a perpetual tendency to diminilh the calibre of the artery: contractility is ufed by the other left to defignate alternate contractions followed by aClive di¬ latation. ACtive dilatation is by no means probable, fince it is unlike the phenomena we obferve in other con¬ tractile ItruCtures of the body; fo that this mult be con- fidered the refult of the heart’s aCtion. But, with regard to the tonicity which Parry and others allow to arteries, they lay, that this is not the “ contraCtilite par defaut d’extenfion” of Bichat, but a vital power. If fo, is it too much to aflert that a vital contraCtile (truCture, which is expanded, will recover a fmaller calibre than it had originally ? To exemplify this, we fuppofe the fize of an artery equal to 3, and that the impulle of blood injeCted into it ltretches it to 4.. It may be inferred from the known power of contracting fibres in other parts of the body, that, the prelfure being removed, it will reduce its circumference to (fay) 2^ : and this overcomes another objection that has been made to fuppofing the contrac¬ tion and dilatation of arteries ; viz. that this dilatation might impede as much as accelerate the progrefs of the blood, fince it might exilt over the whole arterial fyftem juft at the time the left ventricle contracted. But, if the contraction be brought about in the manner we have Hated, it mult of courfe obferve the lame time in its con¬ traction as the heart itfelf, and confequently may mate¬ rially aflilt the circulation. We fhall alfume, therefore, in our (peculations on the Haematics, the contractility of arteries, ufing this term with the reftriCtion before Hated. We have before faid, that at the extreme branches of the arteries a motion is derived from a capillary attraction exilting between thefe veflels and the blood. This of courfe is no explanation, becaufe we do not know any thing about capillary at¬ traction. It may be ufed, however, to denote that the firme law governs the motions of the blood in thefe living tubes (to a degree) as in inanimate veflels. A motive power is again to be found in the fecernent fyl¬ tem : and here the data of reafoning become fewer than thofe on which it is founded, even with regard to the capillary arteries ; and we can only conjecture, plaufibly, that an attraction exifts between certain parts only of the blood and the Tides of the veflels ; and that the ad¬ dition of a fomething from the nerves is necefl’ary to change thefe parts of elements to the form they exhibit on fecreting furfaces, or outlets. Thepaflage of fluids in the larger abforbents, and in veins, we have before no¬ ticed. It was necefl'ary to recapitulate thefe circumftan- ces, that the whole of them might be borne in mind while treating of the difeafes of this fyftem. With regard to difeafes from quantity of blood, it is to be noticed, that an increafe in the mafs of blood fel- dom exifts unaccompanied by an increafe of the aCtion of the heart ; when this does occur, the blood, although its quantity is increafed, will have its rate of motion di- miniflied. In fuch a cafe, the fmaller arteries, in which, as before ftated, the contractility is greater, in proportion to the fize of the veflel, than it is in the larger arteries, will, from the want of dilatation by means of the heart’s contraction, leflen their fphere of contraction, fo that an increafed proportion of the general mafs of blood will be contained in the larger arterial trunks, in the veins, and in the cavities of the heart. The whole round of the circulation will be obftruCted. The aCtion of the heart will confift of flow feeble contractions, or of inef¬ fectual flutterings. The pulmonic procefs will be imper¬ fectly performed: hence refpiration will be laborious and hurried. 4 PATHOLOGY. hurried, the colour of the blood will be changed, and temperature diminiffed. From the circulation of this blood of unnatural qua¬ lity, diforder of the .whole of the nervous fyftem, and hence of every function in the body, may enfue. If the mafs of blood be increafed, and if the aftion of the heart be alfo increafed, fo as to propel the greater mafs with freedom; in fuch a cafe, the contractility of the fmaller arteries being more powerfully oppofed, thefe veflels will yield more readily to the current of the blood; they will therefore receive a greater quantity of that fluid, and confequently an increafed quantity' mull pafs by their termination. The quantity of fecreted and of exhaled fluids will be increafed ; the blood will flow with greater force, and in. greater quantity, throughout the whole round of the circulation. As an increafed quantity of blood will pafs, in a given time, through the pulmonic circuit, refpiration mu ft be more quickly performed, otherwife’that fluid will not duly undergo the pulmonic procefs. The fenfibiiity of the nervous fyftem may be in¬ creafed, and the functions of that fyftem may be more freely performed. Hence all the functions dependent on nervous influence will be exalted. The diminution of quantity in the blood generally manifefts itfelf by the want of aftion in the nervous fyf¬ tem, and hence of ail the Accretions. But this ftate is not likely to laft long; and indeed generally remedies it¬ felf, except when the affimilating organs of the body are difeafed. Faffing over thefe plethoric ftates, we come to the con- fideration of an alteration in the contraftility of the blood-veffels, or of the common malady called inflam¬ mation. When a violent blow is given to an external part of the body, the four following circumftances are after a time obfervable ; viz. rednefs, tumefaftion, pain, and heat. Prefently a- throbbing is felt in the arteries going to the part, and a difturbance takes place in the vafcular and nervous fyftem, concifely called fever, and a change in the quality of the blood. To account for thefe fimple appearances has puzzled the medical philofophers of every age, and it puzzles them fill!. In our Introduction we have noticed the wild fpeculations of the earlier phy- flcians. Faffing over Boerhaave’s notion, that vifcidity of blood was the caufe of inflammation, and that of Cullen, which, like this theory of fever, refts on the affumption of a fpafm of the extreme arteries, we proceed to notice the celebrated opinions of Mr. John Hunter. According to him, inflammation is to be conlidered only as a difturbed ftate of parts, which requires a new but falutary mode of aftion to reftore them to that ftate wherein a natural mode of aftion alone is neceflary. From fuch a view of the fubjeft, therefore, inflammation in itfelf is not to be conlidered as a difeafe, but as a falutary operation, confequent either to fome violence or to fome difeafe- Effewhere the author remarks, the aft of inflammation is to be conlidered as an increafed aftion of the veflels, which, at fir ft, confifts limply in an increafe or diftention beyond their natural lize. This increafe feems to depend upon a diminution of the mufcular power of the velfels, at the fame time that the elaftic power of the artery mult be dilated in the fame proportion. Owing to this dilata¬ tion, there is a greater quantity of blood circulating in the part, which is according to the common rules of the animal economy : for, whenever a part has more to do than Amply to lupport itfelf, the blood is there collected in larger quantity. The /welling is produced by an ex- travafation of coagulable lymph, with fome ferum ; but this lymph differs from the common lymph, in confe- quence of palling through inflamed veflels ; it is this lymph which becomes the uniting medium of inflamed parts ; veflels Iboot into it, and it has even the power of becoming vafcular itfelf. The pain proceeds from fpafm. The rednefs is produced either by the arteries being more dilated than the veins, or becaufe the blood is not 193 changed in the veins. When, after an ibjury, a part cannot be reftored to health by inflammation alone, or by adhefion, then fuppuration, as a preparatory ftep to the formation of granulations, and the confequent reftora- tion of the part, takes place. The veflels are nearly in the fame ftate as in inflammation ; but they are more quiefcent, and have acquired a new mode of aftion. See Hunter on the Blood, Inflammation, &c. That the capillaries are diftended in inflammation is pretty generally agreed ; and, this allowed, we clearly ex¬ plain the increafed fize of the part, without admitting that lymph is extravafated, a faft of which we have no proof. We have not fpace to enter at full into the proofs of the diftended ftate of the capillaries. There is lefs dif- cuffion required about this diftention, however, than it has been the falhion to enter into ; for it is vifible to the naked eye, and is (till more clearly ihown by the micro- fcope. The independence of this diftention on the heart is alfo pretty clearly eftabliffied ; for we obferve bluffing from fliame or ire, and a rednefs in various parts of the body, without general accelerated pulfe. But, though the diftention of the capillaries in inflam¬ mation is pretty generally allowed, pathologifts are by no means agreed as to the rate of motion which the blood undergoes in them ; fome, as Wilfon, aflerting that the velocity of the blood through an inflamed part is diminiffed ; others ftating that it is increafed. Dr. Parry fliows very clearly, that this is of little confequence to our fpeculations on this fubjeft; but properly remarks, that, if the velocity be diminiffed, yet, the quantity be¬ ing increafed, the momentum mult ftiii be greater than ordinary. Again ; a queftion arifes, whether the arte¬ ries retain during inflammation the alternately-con trail¬ ing force which we have affigned to them in health, or whether this power is loft. The proofs of the firft alter¬ native reft on what is obferved by means of the micro- fcope on the tranfparent parts of cold-blooded animals; as, for inftance, on the web of a frog’s foot. It is- there feen, that, on the application of ftimuli to a certain de¬ gree of force and for a certain time, a permanent or un¬ varying dilatation of the capillaries fupervenes, and the blood feems to move (lowly. This obfervation is not worth much, however, becaufe even the alternate con¬ tractions of the capillaries are not vifible in the fituation above mentioned, on account of the fmall fize of the veffel . We may adduce a pathological obfervation more ftrongly corroborative of the inert dilatation of the capil¬ laries in inflammation ; which is, that, whereas the ex- hauftion of the contents of arteries (not having been thus aft'efted) is met with almoft invariably, inflamed ar¬ teries are not exhaufted of their blood. The pain in inflammation is not eafily accounted for. That the fenfibiiity of the nerves is much increafed is evident from the extreme uneafinefs which ordinary im- preffions produce on them when in a ftate of inflamma¬ tion ; but we are ignorant by what means this pain is produced-; It has been attributed to the preffure of the diftended capillaries ; and this appears plaufible at firft view ; Lut the idea is oppofed by the fails, that many parts fuffer diftention of their capillary veflels without pain occurring ; and that the -pain is often mod fevere before this diftention begins ; as for inftance, after a blow, or in the cafe of gout, in which difeafe, as is well known, the coming-on of rednefs and fwelling often relieves the excruciating pain of the firft attack; fo that we are com¬ pelled to ftate increafed fenfibiiity as one of the eflential circumftances of inflammation, but we cannot trace the caufe of its produftion. The increafed warmth of the part has been fuppofed to depend upon the prefence of an increafed quantity of blood. But, as the extrication of heat is a procefs which is dependent upon the ner¬ vous fyftem, and confequently influenced by altered con¬ ditions of that fyftem, the increafed warmth, and the in¬ creafed evolution of heat, which accompany inflamma¬ tion, 194 P A T H O tion, may be chiefly attributed to the irritated ftate of the nerves. And accordingly we find, as Mr. Hunter’s well-known experiments teftify, that the heat of inter¬ nal parts (to which the office of extricating heat does not belong) have not their temperature increafed during in¬ flammation. It is worthy of remark, that the real in- creafe of heat in the inflamed part is not fo great as the feelings of the fuft'erer might lead us to fuppofe, the thermometer feldom indicating very remarkable changes in this refpeft. To the irritated ftate of the nerves we muff: therefore look for this fenfation of exalted tempe¬ rature. Mr. Hunter’s account of the rednefs of the part feems very probable, efpecially if we add to what he has (aid on the fubjeft, that the total want of fecretion muff pre¬ vent the chemical change on which the darkened colour depends. It appears then, that the tw'o dates of exalted fenfibility of nerves on the one hand, and plethora of the capillary veflels on the other, account for the four firft phenomena of inflammation ; and it would perhaps pre- ferve us from much obfcurity in our fpeculations, if we afiumed the exiftence of thefe ftates without endeavour¬ ing to penetrate into the mode of their production. The two ftates of altered nervous fenfibility and al¬ tered mufcular or vafcular contraftility, are capable of feparate exiftence. Plethora is well known to produce fometimes no pain ; and the mod excruciating pain, as for inftance in tic doulereux, is often unaccompanied by inflammation. In the majority of cafes, however, thefe ftates feem to follow each other. The obftruftion of the circulation in a limb caufes pain and inflammation ; and impreflions w hich can only aft through the medium of the nerves caufe the fame aftion. The primary impreflions which diforder the properties of an artery, mud occur through the medium of the nerves, or of the contained blood. From what we obferve of the effefts of an undue degree of nervous influence being tranfmitted to one part, as in cafes of fatigue, &c. we are led to infer, that the exceflive tranfmifiion of nervous power brings on two kinds of alteration in the contraftility of an artery. It may pro¬ duce increafed contraftion; and this will furely be fol¬ lowed by fuch a diminution of that force as accords with this remarkable and well-known law obferved in con- traftile fibres over the whole body; that they, having exerted their funftion beyond a certain point, lofe their contraftility for a given time. Again ; the nature of the nervous impreftion may be fuch as to weaken or direftly impair the contraftility of the veil'd, and thus diftention of the arteries may occur without any previous contrac¬ tion. The alterations induced by the bad quality of the blood will be of the fame two kinds; a direft diminution or direft increafe of the contraftility of the veil'd ; the former being lefs uniformly followed by the latter ftate than when it arifes from nervous influence. Thefe fafts form the bafis of our theory. It muft not be forgotten, that this reafoning with re¬ gard to the ftate of veflels in inflammation has been thought to be overthrown by fome, becaufe it is inade¬ quate to explain the various appearances and produfts ; as of inflammation, the different cutaneous phlogofes, eryfipelas, terminations in gangrene, ulceration, &c. And thefe authors have talked of various kinds of inflam¬ mation ; as that arifing from different morbid poifons, See. To this we reply, that we do not take inflammation in this wide fenfe : all we know of the funftion of the vafcular fyftem of red blood demonftrates that this (yf- tem is capable only of a change of the contraftility of its veflels ; and no diminution or increafe (and diminu¬ tion or increafe are the only changes in contraftility of which we can form any clear notion) will account for a variety in the appearance of inflammation. We muft therefore look to the fecernent fyftem for the various forms of inflammation ; and, though the little we know LOGY. of thefe veflels keeps us ftill much in the dark on the fubjeft, yet the phenomena in queftion admit of our forming plaufible and general deduftions from the in¬ ferred properties of the white veflels. Indeed the effefts of inflammation depend much upon the nature of the fecretion carried on in particular parts. Thus, when inflammation is feated in a mucous furface, (i. e. on a furface poflefling veflels which fecrete and pour out mu¬ cus,) an increafed quantity of mucous fluid will be poured out. When a furface upon which exhalants open (or, in other words, a ferous furface) is the feat of in¬ flammation, that ftate is, in many inftances, followed by increafed flow from thofe veflels. The irritated (fate of the nerves alone would difpofe the exhalants to give paflage to an increafed quantity of fluid ; and the lame eft'eft might refult from Ample plethora. There are other fluids which are the produfts of fuch veflels as are fituated in an inflamed part. As the blood furnilhes the materials for all fuch fluids, fo will the plethoric ftate of the blood-vefi’els, during inflammation, furnifn an in¬ creafed quantity of thofe materials, while the feparation of them from the blood is influenced, or produced, by the ftate of the nerves. In each of thefe cafes, we have ftrong evidence that the fecernents are the parts pecu- liarly affefted, while the ftate of the capillaries is the fame; fo that we may conclude, that inflammation is in all parts and ftruftures the fame; i. e. a dilatation of the capillaries, while its various appearances arife from the changes which the fecernents undergo, whether that change be in the pouring- forth of unnatural produfts, or aflimilating and retaining thofe produfts in their cavi¬ ties. In other words, that variety of fecretions is the concomitant, not the eflential, circumftance of inflamma¬ tion. The fame notion may be extended to furfaces in which fecretions are not poured out, but depofited in the cellular fubftance ; as eryfipelas, and various unbroken cutaneous defcedations. We have laid, that diftended capillaries and the ex¬ treme fenfibility of nerves account for the four local phenomena of inflammation — heat, rednefs, fwelling,and pain. We muft not forget to mention, that the diften¬ tion of the capillaries is, as Dr. Haftings has (liown, ge¬ nerally preceded by increafed aftion or excitement, in which the veflels are fmaller, and contraft probably with greater frequency. This is fo clearly proved by Dr. H. that we (hall not relate his experiments or repeat his ob- fervations, but refer the reader to the feries of experi¬ ments which he has publilhed (on bronchitis) ; the fa ft: is of importance, lince it (hows that excitement, which we have been wont toconfider a minor fpecies of inflam¬ mation, is really an oppofite procefs. The difcufilon of the general phenomena of inflamma¬ tion, fever, and the huffy appearance of the blood, re¬ quires us to (how in wdiat the ftate denominated Jeter confifts, how it is connefted with local inflammation, and how a general change in the quality of the circulating fluids arifes, from the local inflammation or from the general difturbance. With regard to the altered quality of the blood, this fluid, taken from a patient labouring under inflammation, exhibits peculiar appearances. The blood, when it has efcaped out of the living veflels, fpontaneoufly feparates into two diftinft parts, the ferum and the craffamentum. The laft is a compound fubftance, confifting chiefly of coagulating lymph and red globules, the molt heavy in¬ gredients in the blood. Now it is to be obferved, that blood taken away from perfons affefted with inflamma¬ tion, is longer in coagulating, and coagulates more firm¬ ly, than when drawn from people in other circumftances : hence the red globules, which are very heavy, not being fo foon entangled in the lymph, defcend by their gravity’ more deeply from its furface, which, being in this man¬ ner more or lefs divefted of the red colouring matter, is, from its appearance, termed the huffy coat , or inflammatory cruft , The firmer and more compaft coagulation of the, lymph 195 PATHOLOGY. lymph comprefles out an unufu.il quantity of ferum from it, and the furface of the Jizy blood, as it is fre¬ quently called, is often formed into a hollow, the edges being drawn inwards. Thefe changes in the blood are, in fome cafes, a more infallible proof of the exiftence of inflammation than the pulfe itfelf. In peritoneal inflam¬ mation, the patient fometimes fee ms to be in the mod feeble (late, and the pulfe, abftraftedly confidered, would rather induce the pra&itioner to employ tonics and fti- tnulants than evacuations ; but, ftiould the continuance or exafperation of the diforder, or any other reafon, lead the furgeon to ule the lancet, then the huffy coat, the con¬ cave jurfuce of the blood, and the large quantity of J'erum, clear away all doubt concerning the exiftence of inflam¬ mation. It is important, therefore, always to infpeft the blood after it is cooled, with a view to the detection of this unnatural ftate. But every pra&itioner ought to hear in mind, that, in pregnant women, and in a few anomalous conftitutions, the blood, taken away by the lancet, always exhibits the foregoing peculiarities, though inflammation may not prevail. The above alteration in the quality of the blood has never been accounted for. As it is only obfervable in conftitutions where fome fource of nervous irritation is prefent, we fliould be inclined to refer its appearance to that irritation. We fliall hereafter have occafion to (how how important a part nervous excitement plays in deve¬ loping the phenomena of fever; and it is to be remarked, that, while inflammation is merely local, no change takes place in the ftate of blood in general ; but no l'ooner has fever become eftablilhed, than the blood exhi¬ bits the buffy coat. Now, in the inftance of pregnancy, it will be allowed on all hands, that the gravid uterus is a perpetual fource of nervous irritation to molt females; and it has been remarked, that thofe anomalous confti¬ tutions in whom this appearance has been always met with have been perfons who exhibited excefllve fenfibility in the nervous fyftem, or were, in other words, of the nervous temperament. ' The aftion of the nervous fyftem may produce this change in the blood by the difproportionate evacuation of the elements of the blood, as in excefllve fecretion, or by the undue retention of fome of thefe parts ; both of thefe difturbances being of courfe effected by the ac¬ tion of the nerves on the l’ecreting veffels. The prefent ftate of our knowledge does not permit us, however, to (how in what ftruftures this conjectured deprivation or re¬ tention is effefted. In confidering the next general fymptom of inflamma¬ tion, fever, we fliall enter into a full account of the febrile ftate, both idiopathic and arifing from this a£tion, or, as it is termed by furgeons, fymptomatic fever. We have gone fo far into the fubje<5t of inflammation, becaufe it was neceflary to the right underftanding of the febrile phenomena we have next to explain. Thefe general views having been taken, we fliall trace the various forms inflammation exhibits in the different ftrudlures, and the different changes in fecretion which accompany it, when ('peaking of Phlogotica, the fecond order of this clafs. It is generally allowed that no general definition of fever, capable of embracing all its varieties, has been given. A general alteration is found in the organic, oftentimes in the animal, funftions, the former fuffering the firft changes. The fanguineous and mufcular fyf- tems are aifo altered ; and, when the difeafe is eftablifhed, all the functions feetn impeded together. This ftatement, that fever confifts in an alteration folely of almoft all the fun&ions of the body, is, it mull be confefled, extremely vague; yet it is the only one which will embrace all the varieties of fever; for cafes are recorded where the heat was not exalted without the pulfe being fenfibly aug¬ mented, and vice-verfa ; and fo on of every other func¬ tion. VOL. XIX. No. i*9 7. Order I. Pyrectica, [wvpelos, Gr. from wup, fire.] Fevers. Here we have the heat and number of the pulfe preter- naturally augmented; ufually preceded by rigor, and followed by perforation ; pains fixed and wandering; laflitude, debility of mind and of the voluntary mulcles. In our introduction we have mentioned fome of the snoft remarkable opinions as to the effential nature of fe¬ ver. The fpeculations of Brown and Darwin were no¬ ticed 1 and many havearifen fince; but there are few which we now deem worth detailing. The firft which, from the ftrong faffs by which it is fupported, is deferving of no- tice, is the theory of Dr. Clutterbuck. We fliall copy from the article Fever of Dr. Rees’s Cyclopaedia, Dr. Bateman’s (this gentleman being underftood to be the writer of that article) expofition of Dr. Clutterbuck’s theory, and his luminous objections ; referving our own remarks for the end of it. Dr. Clutterbuck’’ s Theory. — Fever has ufually been called a general difeafe, affefling all the functions, in contra- diltinCtion from local difeafes, in which fome particular organ is the primary feat of the diforder, and the affec¬ tions of the other functions are fecondary or fymptom¬ atic. But Dr. Clutterbuck denies the exiftence of ge¬ neral difeafe, and maintains that all general or extenfive derangement of the animal fyftem is referrible to local derangement in fome one organ. The organ univerfally affeCted in all the varieties of idiopathic fever; which differ but in degree, as well as in thofe which arife from fpecific contagion, as malignant fore throat, fcarlet fe¬ ver, fmall pox, See. is, in the author’s opinion, the brain . This is manifeft, he contends, from the fymptoms, as the head-ache, the depreflion of ftrength, and other de¬ rangement of the animal functions, the delirium, the tremors, failure of vifion, See. It is manifeft from the nature of the remote caufes which 'aft chiefly on the brain and nervous fyftem, as intoxication, fear, grief, and other paffions, external irritation, not to mention nmf- mata and contagion, of the operation of which we are ignorant; as well as from the predifpofing caufes, which probably confift in a deficiency of fenfibility, as in idiots, negroes, old people, and infants’, but it is more particu¬ larly manifeft from the confequences of fever, whether after recovery, or after death, afeertained in the latter cafe by diffeCrion. Among the confequences of fever, which are not uncommon after recovery, are an impaired condition of the fenfes 5 fuch as deafnefs, imperfeCt vi¬ fion, depraved tafte ; paralytic affeClions, or convulfive complaints, as epilepfy and chorea ; derangement or lofs of the mental powers, fuch as melancholy, great irrita¬ bility of mind, lofs of memory, or even complete fatuity. The confequences obferved on difleflion, after death occafioned by fever, are frequently vifible difeafe of the brain, of which feveral examples are quoted by the au¬ thor. He then proceeds to (how, that the local affection of the brain, thus manifeft, is in fafl inflammation of that organ ; or that fever, therefore, “ is nothing lefs than a fpecies of phrenitis, or topical inflammation of the brain,” and (hould be arranged in the order of Phlegma- fia, with pleurify, enteritis, and other fymptomatic fevers: but, as Phrenitis has been generally applied to a particu¬ lar form of inflammation of the brain, and implies deli¬ rium, which does not always occur in fever, although it is a frequent fymptom. Dr. Clutterbuck propofes the term Encephalitis as the denomination for fever. The arguments adduced in proof of the notion that the topi¬ cal affedlion of the brain, in fever, is inflammation, are, 1. The analogy between the fymptoms of fever and thofe of inflammation, viz. pain, heat, throbbing, acute fenfi¬ bility, &c. being common to both. a. The occafional buff of the blood in both. 3. The fimilarity of feveral of the exciting caufes of both. 4. The occafional alter¬ nation of fever with inflammation. 5. The analogy in regard to the cure of the two difeafes generally, as by means of blood-letting, vomiting, fweating, purging, bli lie ring, and the application of cold. 6. The fymptoms 3 E ©f 196 PATHOLOG Y. V. of fever not being diftinguifhable, on the whole, from rbofe which belong to phrenitis, as defcribed by authors. 7. That the morbid condition of the brain, difcovered by difledtion, is fuch as implied previous inflammation. “ In the firft place,” fays Dr. Bateman, “ Dr. Clutter- buck, like other theorifts enamoured of a favourite doc¬ trine, appears to have laid too great itrefs upon thofe phenomena which fupport that dodtrine, and to have conceded lefs to oppofing fadts than they are entitled to claim. Hence, in retracing the delineations of fever, in the words of the mod creditable writers, he has diftin- guiftied by italics all thofe flgns which indicate derange¬ ment of the encephalon, by which they are made to Hand the molt prominent features in the pidt ure. Hence, alfo, he has afiumed the pofition, that the derangements of the natural and vital fundtions, which are nearly, if not altogether, as univerfal concomitants of fever as the dif- orders of the animal fundtions, are neverthelefs, in all cafes, fecondary fymptoms, originating from the primary affedtion of the brain. Thus the naufea, the vomiting, the total lofs of appetite and of the digeftive power, are believed to be always fympathetic of the affedtion of that organ ; fo likewife is the quickened adlion of the heart and arteries, and of the refpiration. That this, however, is a gratuitous afl’umption, may be fhown, 1. By attending to the very hiftories which Dr. Clutterbuck has quoted, in which the occurrence of the deranged condition of the ftomach is as conftantly mentioned as that of the diforder of the encephalon. 2. By obferving, that the fympathy between the brain and the ftomach is perfedtly reciprocal; fo that the brain fuffers in fympathy with the ftomach, not lefs manifeftly than the ftomach with the brain. 3. .Byremarking, that the fymptoms of dif- ordered ftomach are capable of being relieved or re¬ moved, while the fnfipofed caufe (affedtion of the brain) remains; the thirft being allayed, and the ficknefs re¬ moved, by changing theftate of thefkin only, the former by moiftening it with water, the latter by exciting fweat, as obferved by Sydenham. Whence Drs. Cullen and Darwin feem to be rather j u ftified in attributing the de¬ rangement of the ftomach, when it is affedled fecondarily, more frequently to its fympathy with the ftateof thefkin than of the brain. “Farther, the connexion of many of the leading fymp¬ toms with fome diforder of the brain, or common fenfo- rium, is admitted by all, and equally favours the hypo- thefis of the other authors, as well as that of Dr. Clutter- buck ; fince, whether the brain is primarily or feconda¬ rily affedled, certain phenomena in the nervous fyftem mult neceffarily enfue. We have juft ftated fome rea- lons for believing that it is often thus fecondarily affedt- ed ; and it now remains to offer our reafons for fuppofing that inflammation of the brain, when it does occur in fever, (to which we cannot confider it as efl’ential,) is commonly fecondary likewife. “ The firft fymptoms of the affedtion of the brain are by no means thofe which indicate inflammation or un- ufual excitement of the fenforium; on the contrary, they are fuch as indicate an oppofite Hate, which Dr. Cuilen has termed atony and collapfe, and Dr. Darwin torpor ; the head-ache itfelf, according to the obfervation of Dr. Fordyce, is altogether diftindt from the head-ache of inflammatory excitement, or of the hot ftage. Any fymptoms that can be interpreted as indications of local inflammations, fuch as rednefs of the eyes, protrufion of the features, fluftied countenance, throbbing of the arte¬ ries, and even delirium, are theappearances belonging to a fubfequent period of the fever. But at this fubfequent period, inflammatory congcftions are liable to occur in the other vifcera, if not fo frequently, at leaft not unfre- quently; as in the ftomach, for example, the inteftines, the lungs, and other organs. This fadt has been noticed by many phyficians of accurate obfervation. Riverius long ago remarked, that acute and malignant fevers fcarcely ever occur unaccompanied by inflammation in fome one of the vifcera; and he has ftated in another place in molt diftindt terms, that wfe ought aftiduoufly to recoiled!, that all thofe fevers, with which local inflam¬ mation is conjoined, are not fymptomatic, but often idio¬ pathic, and that the inflammation fupervenes, not being the caufe but the confequence of the fever ; quafebrem if am non effioit, Jed illi potius fuccedanea rjl. Thus, he adds, ‘ We frequently obferve in pradtice, that patients labour under continued fever for a day or two before pain of the fide and other fymptoms of pleurify appear ; thus alfo many perfons on the third or fourth day of fe¬ ver fall into inflammation of the brain, &c. Sic nobis Jiequenter in vfu pradico vide. re licet agrotuntes, ab initio Jebre continua laburantes per unam out alteram diem ante~ quam dolor lateris el alia pleuritidis Jigna appurcunt : J'tc multi tertia v el quarta febris die in piirenitidem incidunt , Sj-c.' (River. Prax. Med. lib. xvii. cap. i.) Dr. Donald Monro, vvhofe teftimony on fubjedts of morbid anatomy is of conliderable weight with Dr. Clutterbuck, remarks, when fpeaking of malignant fever, that ‘ this fever oc- cafions in general more or lefs rednefs (I do not know that we can properly call it true acute inflammation) of the membranes ; and the febrile matter is apt to fall on particular parts, and there to create abfcefles, particu¬ larly in the brain, the lungs, and the glandular organs." (Treatife on Military Hofp. vol. i- p. 237. and Dr. Clutterbuck’s Treatife, p. 172.) Obfervations to this ef- fedt might beeafily multiplied, and we have already enu¬ merated feveral in a former part of this article. It is fomewhat Angular, that Dr. Clutterbuck, who quotes the remark of Dr. Monro, fhould deem it favourable to his hypothefis of excluiive inflammation of the brain ; flnce it obvioufly proves an equal liability to inflamma¬ tion in other organs, if it proves any thing. Now, it mult be admitted, that, if fever depends upon inflam¬ mation of the brain, and is merely fymptomatic of fuch a ftate, this ftate mull be always prefent, when the fymp¬ toms of fever occur; one'clear negative example is lurely fatal to the theory. Dr. Beddoes coliedted a confiderable quantity of evidence from the hiftories of difledtions, made during the prevalence of feveral epidemic levers on the continent ; from which it is proved, indeed, that congeftion, or fome other morbid appearance, was fre¬ quently oblerved in the brain or its membranes ; but it is alfo Ihowing, that abfcefles, gangrene, or other marks of inflammation, were not lefs frequently found in the vifcera of the thorax and of the abdomen, especially in the ftomach and liver. Thefe fadts we have detailed, when fpeaking of the confequences of fatal fevers, as difcovered by difledtion ; and it is unneceftary to repeat them here. Dr. Beddoes is fairly led (fuppofing the fadts accurately reprefented) to this inference, that, in idiopa¬ thic fever, the ftomach and contiguous parts have been found more conftantly and more deeply affedted with in¬ flammation, than the brain and its membranes. (Re- fearches, Anatomical and Pradtical, concerning Fever, See. by T. Beddoes, M. D. publilhed in 1807.) But, left the teftimony of authors of little note may bequeftioned, we (hall quote that of one of the molt able and experi¬ enced of our hofpital-phyflcians. Dr. Lind of Haflar. Speaking of a deftrudtive contagious typhus, which pre¬ vailed in the French fleet in 1757, he fays, ‘the fymp¬ toms of the fever were the fame as we have already given in the defeription of the gaol-diftemper. On difledtion, the brain of thofe who died was found perfectly found, though during their ficknefs the head had always ieemed greatly affedted : in two cafes only, out of twenty which were infpedied, the blood-veflels of it appeared a little enlarged. The lungs were generally found gorged with blood, and feemed to have a gangrenous difpolition. The abdomen more immediately luffered by the difeafe, parti¬ cularly the liver, ftomach, and inlejlines ; in the inteftiries there was often found a green offenlive liquor, fometimes worms." (See Lind on Fevers and Infections, chap. iv. 197 PATHOLOGY. For thefe reafons Dr. B. concludes, “ that inflamma¬ tion occurs only occafionally in the brain ; that this or- jan is liable to inflammation only i ri common with the other vifcera; and that inflammation is in all the organs a fecondary refult of fever, and not its eflential caufe. In this view of the fubjeft, all the arguments from ana¬ logy between fever and inflammation, which Dr. Clutter- buck has brought forward, may be (and indeed muft be) admitted ; while, at the lame time, they add no weight to his theory: for the analogy is equally favourable to the notion of a fecondary as of a primary occurrence of inflammation. And we cannot but obferve, before we take leave of thefe doCtrines, that the analogies which Dr. Clutterbuck has pointed out, as well as the various faCts which we have quoted from Riverius, Monro, Bed- does, and Lind, fend to confirm the hypothefis of Dar¬ win, under which thefe faffs, contradictory as they are, to the opinions of Dr. Clutterbuck, are reduced to a perfeCt coniiltency.” It may be added, that a doCtrine, according molt accurately with that of Dr. Cl. is taught by Dr. Ploucquet, in the univerfity of Tubingen. Now, (peculating upon this contention between the two molt eminent writers on the fever of this country, it will appear, that Dr. Ciutterbuck’s hypothefis is neither proved by himfelf nor refuted by his antagonift. For, fuch is the fympathy between all parts of the body, that, if inflammation of the brain be produced, a general in- creafed adtion of the heart and arteries occurs, and thofe parts predifpofed to inflammation will take on that ac¬ tion, or inflammation arifing on other parts will as furely difturb the cerebral. The fucceflion of fymptoms does not overthrow this theory, becaufe, though the firft fymptoms denote diminilhed energy of the brain, fuch a (fate is, according to a law before laid down, moll likely to be followed by the oppofite Itate. To the teltimonyof Lind and others, Dr. Clutterbuck objeCts, that we are not acquainted with the appearance of abrain perfectly found ; and the changes in that deli¬ cate. ItruCture muft often be infcrutable; and bethinks that few perfons die without fome morbidity of the brain. We are not, however, difpofed to advocate the opi¬ nion of Dr. Clutterbuck (principally for the laft objec¬ tion, which his anfw'er does not overthrow), but to ihow that it is not much afteffed by the arguments in queftion ; and we have no hefitation in faying, that, whetheras a caufe or a confequence, inflammation of the brain is more gene¬ rally found in the fevers of this country than anyotherkind of lefion, as indeed we fhould naturally expeCf to find in civilized fociety, where the brains of the inhabitants are for the molt part in a Itate of unnatural excitation. We fltould therefore pay thegreateft attention (atlealt in fe¬ vers of this country) to the occurrence of inflammation of the brain. With refpeCt to the gojiric origin of fever, hinted at by Dr. Bateman in the preceding extraft, and which when firit promulgated obtained few fupporters; it is remark¬ able, that it is now believed in (with fome modification) by many of the mod eminent continental pathologifts, among the firftof whom is Brouflais. This author con¬ ceives that the plague, and all varieties of fever, whe¬ ther adynamic, ataxic, typhous, or yellow, are nothing elfe than various fpecies of inflammation of the mucous membranes of the ftomach and (mail inteftines, differing in their degrees of violence, as well from the peculiar conftitution of the patient, as thecaufes which may have produced them. M. Brouflais terms thefe maladies goj- Iro-enttrites, not becaufe he believes that, in all cafes, the ftomach and inteftines are irritated in the fame degree, but becaufe the affeCtion which commences almoft conftantly in the firft of thefe organs is quickly propagated to the fecond ; and from the curative indications being the fame, whatever may be the part moll violently affecied. He endeavours, to point out, from the fymptoms, the princi¬ pal feat of irritation in the different llages of the difeafe. When it is violent, and has continued for a certain length of time, he has conftantly obferved that it has been com¬ municated throughout the whole extent of the fuperior portion of the digeftive canal. The large inteftines are, however, ordinarily free from diforder; and, when they are implicated, the particular fymptoms give notice of it to the attentive pradl itioner. In proof of this theory, Brouflais aflerts that all the modifications of the gnftro - enteritis prefent the following fymptoms: lofs of appe¬ tite; more or lefs of urgent third; on the centre of the tongue a coating, which is variable in thicknefs, denfity, and colour; and, about the point and lateral parts of that organ, a rednefs that varies in colour from a rofe- tint to the moft fiery hue : appearances always noticed by authors who have written of fever, but which M. Brouflais confidersas moft pcfitive and conftant figns of gaftric irritation. The heat of the Ikin being increafed, particularly about the abdomen and the epigaftric region, and its conveying a fenfation of roughnefs to the hand, is generally, according to this author, the effect of irri¬ tation of the mucous membrane of the digeftive organs. The morbid aCtions, manifelled in the nerves and the brain, as depreffion of fpirits, morofity, cephalalgia, even the moft profound ftuporand depreffion of the nervous power, or, on the contrary, the moft furious delirium, are confidered to be the refult of fympathy with the fto¬ mach and fmall inteftines ; as alfo the violent and almoft infupportable pains in the joints which attend fome fevers. In examining the moft frequent caufes of febrile dif- eales, M. Brouflais thinks we find evidence of exifting irritation of the mucous membrane of the ftomach and fmall inteftines, becaufe thofe caufes adt, either direCtly or indirectly, on the digeftive lyftem. Thus, repeated error's of regimen, tire ingeftion of acrid and irritating fubftances, the influence of putrid miafmata, &c. appear in the firft order ; amongft thofe of the fecond may be counted thofe miafmata which, being received into the fyftem through the Ikin, or by the refpiratory or digeftive organs, always evince their influence on the latter; ex- celfive heat of the atmofphere, which excites the Ikin, and fympathetically the ftomach and fmall inteftines, &c. Moreover, gaftric irritation, as all authors have obferved, is very often the precurfor of gnjiritis, in the common application of this term, or of gaftric, mucous, and atax¬ ic fevers, which fucceed each other in the above order in the fame individual. The caufes that produce typhus, yellow fever, and plague, fometimes confine their influ¬ ence to the determination of a flight degree of gaftric ir¬ ritation. In the progreffive increafe of the fymptoms which characterize the paflage of the malady from the moft trifling to the moft violent form, Brouflais thinks it is abfolutely impoflible to obferve any exaCt period at which the affeCtion precifely changes in its nature: every thing, on the contrary, indicates that it is the fame orga¬ nic lefion, acquiring more intenfity, and producing more alarming fympathetic affections. He therefore fees no reafon which Ihould authorize us to divide the collection of fymptoms into two, three, or more, feCtions, and to fay that two or three different maladies have fucceeded to each other. From the efteCts of medicines, which may lead us to recognize the nature of difeafes he (till fees further cor¬ roboration of the theory in queftion. Having Ihown that „ antiphlogiftic meafures are thofe which moft frequently fucceed in the maladies of which we treat, anti that, the fortunate refults he has obtained from their application are beyond any comparifon in extent with the fuccefs that has enfued from contrary modes of treatment; he ralhly infers, that tonics and ftimulants increafe the febrile com¬ motion, becaule they ftimulate the inflamed furface. But the ftrongeft evidence of the theory of Brouflais is drawn from his numerous dhTeCtions. “ On the termi¬ nation of gaftro-enteritis, or of the numerous maladies which V PATHOLOGY. 108 which reprefent the different degrees of that affe&ion, we always find the-confequences of inflammation of the digeftive canal ; but the afpedl and nature of thefe re¬ mains of organic irritation prefent feveral varieties, the knowledge of which is of confiderable importance. When the difeafe has been but of Ihort duration, we fometimes find the tunics of the ftomach and inteftines injected with blood, and prefenting throughout their whole extent, even on their external furface, a rofe-co- loured hue that is not natural to them, without difcover- ing manifeft inflammation of any determined portion of the mucous membrane. This Ihows that thefe organs have been the feat of irritation that has occafioned an in¬ ordinate afflux of blood to thofe parts, but that inflam¬ mation had not developed itfelf. We may compare this ftate to that of apoplexy, where the veffels of the brain are found diftended with blood, without any eft'ufion having taken place. It would not, however, be right to reprefent to ourfelves the mucous membrane as little co¬ loured with blood during life as we may find it after death : the tongue is very often of a bright red colour in the patient, but becomes pale and dilcoloured in the dead body. It feems that irritation mull have conti¬ nued for a confiderable length of time to render the co¬ lour of the parts permanent after death ; that is to fay, to combine a certain quantity of the red fluid with their tifl'ue.” In general, whatever may have been the diforder ob- ferved in the fuperior parts of the inleftinal canal, the inferior portion (that is, the large inteftines) is unaf¬ fected. But, when gaftro-enteritis has been accompa¬ nied with diarrhoea or dyfentery, we find traces of inflam¬ mation of the latter parts alfo ; this extent and compli¬ cation of organic lefion conllitutes the epidemic dyfen¬ tery. A theory fimilar to this has much obtained in Ame¬ rica. Dr. Chapman, profellor of medicine in the univer- lity of Pennfylvania, (in his Elements of Therapeutics,) Hates, that “ fever, whatever may be the caufe, is always a difeafe of fympalhy, having the primary link of its ulti¬ mately lengthened and complex chain in the ftomach. It is upon this organ that contagion, marlh-effluvia, and other noxious matters; aft ; and hence, precifely as in the cafes of poifon, a local irritation at firlt occurs, which, if not at once arrelted, fpreads itfelf, by multi¬ plying the trains of morbid aflociation, till the difeafe becomes general, involving more or lefs every part of the animal economy.” Dr. Harrifon (in the Gulftonian Lefture for the year 1820) has adopted a theory identical with that of Brouf- I'ais. He fays, “ Fever I confider to be a derangement of certain funftionsof the body, dependant on irritation of fome particular part, which becomes a caufe of dif- turbance to the reft of the fyftem by means of the fym- pathy exifting between its feveral organs. But irritation of any part will not give rife to fever; and it appears, that it is irritation of one organ folely that will produce this eft'eft, and that organ is the mucous membrane. The funftions deranged in fever are thofe of the fecretory or¬ gans : hence the morbid ftate of the fecreted fluids, and the alteration of the temperature of the body. From the derangement of thefe funftions arife all the effential phenomena of fever. The increafed frequency of the aftion of the heart and arteries, and the dijlurbunce of the intellects, which ordinarily accompany it, are accidental phenomena, and are not neceflary in order to conftitute fever. The intellefts are often not difordered ; and we not unfrequently obferve typhous fever run its whole courfe without any increafed frequency of the pulfe. “ Difturbance of the funftions of the brain is a gene¬ ral attendant on all fevere febrile. diforders, and, as it is here (hown, is an effeft of the local difeafe already de- feribed ; the delirium being in a dire.61 ratio with the in¬ flammation of the mucous membranes ; as indicated by 4 the inflamed conjunftiva, and other evidences of tins ftate.” Dr. H. likewife afferts, that the moft ftrongly marked cafes of inflammation of the mucous membrane of the ftomach often commence' in this way. The pa¬ tient at firll fuffers an inordinate craving for food, which is not immediately removed by the introduftion of ali¬ ment into the ftomach ; it however ufually fubfides in about half an hour or fo ; but it re-appears foon after¬ wards with increafed violence ; and in a fliort time, as a few days, efpecially if ftimulating food is taken, it be¬ comes a fenfe of abfolute pain, attended with naufea, vomiting, and difguft for every kind of alimentary mat¬ ter, except cool and unirritating liquids. This has often been obferved in yellow-fever, the origin of which is one of the moft fevere forms of inflammation of the mucous membrane of the ftomach and duodenum. The diforder of the ftomach above deferibed is not unfrequently the only fign of the approaching difeafe for one or two days; and we may often witnefs the fame circumftances in the feveral forms of fever that occur in our own climate. “Fever does not immediately refult from irritation of any other part. We find extenfive and very fevere in¬ flammation of ferous and cellular membranes, and of the fibrous and bony ftruftures, and no fever exifts : but, if the irritation of any of thofe parts be participated by the mucous membranes, all the phenomena of fever imme¬ diately appear.” This theory has been by fome confounded with the lu¬ minous one of Dr. Jackfon ; but it certainly differs widely in this point. Dr. Jackfon Ihows that the mucous membrane of the ftomach is the part which ordinarily re¬ ceives the impreflion of contagious effluvia, and that the fame membrane does frequently take an inflammatory ac¬ tion ; but he is far from afferting with Brouflais and Har¬ rifon, that inflammation of this membrane is the effential caufe of fever; i. e. that without which it cannot exift. Again, M. Brouflais is confcious that the firll impreflion giving rife to the phenomena of fever always aftefts the mucous membrane of the Jlomuch, either from the exciting caufe having been immediately applied to this organ, or from its fympathifing with fome remote part in a ftate of irritation ; and, unlefs fuch a fympathy happens in the latter cafe, he confiders that real fever cannot arife. Dr. Jackfon equally inculcates the doftrine of the local origin of contagious fever, but he does not fix this ori¬ gin in any part exclufively; and he, befides, confiders that the Jkin itfelf, properly fpeaking, or the cutaneous' envelopment of the exterior of the body, as well as the mucous membrane of the lungs and alimentary canal, may be the part firft affefted ; and that the irritation of this organ may excite in the fyftem the whole of the phe¬ nomena to which the generic term fever has been applied, without the mucous membrane of the ftomach being ne- ceflarily interefted in the produftion of the feries of fymptoms ; though he dates that fuch an implication does take place in by far the greater proportion of in- ftances. The other point of difference, is the part of the ner¬ vous fyftem which forms the medium through udiich the fymptoms are developed ;' though the reality of a differ¬ ence in this refpeft is not very evident. Dr. Jackfon de- fignates it as the fenforium; by which it appears he means the cerebral fyftem: though he may intend only to fig- nify the principle of fen/ibility generally, without fpecify- ing the particular parts in which it may be feated. M. Brouflais confiders the ganglionic nerves as the effential organs by which the fympathies in queftion are pro¬ duced. The next pathologift whofe theory of fever demands our attention is Dr. Nicholls. We quote from his ex¬ cellent “ Pathology.” A particular and methodic ana- lyfis of the fymptoms which conftitute the feveral ftages of the morbid condition of the fyftem which is thus termed, leads him to conclude that the early Jlage of it refults PATHOLOGY. refults from “diminifhed fenfibility of the nervous fyf¬ tem ; diminifhed adtion of the heart ; a contradted ftate of the fmall arteries.” The height of it, from “ increafed fenfibility of the nervous fyftem; increafed adtion of the heart ; increafed flow of blood through the fmaller arte¬ ries, the oppolition which is made by the exertion of the contractile power of thefe vefl'els being overcome by the increafed adtion of the .heart.” The decline from “ di- ininifhed fenfibility of the nervous fyftem ; enfeebled adtion of the heart ; relaxed ftate of the fmall arte¬ ries.” The refpedtive ftates of the feveral ftages above enume¬ rated, Dr. Nicholl confiders, may occur in either of the three following orders : “ i. Contradtion of the fmall arteries; diminiflied adtion of the heart; torpor of the nervous fyftem. 2. Diminifhed adtion of the heart; tor¬ por of the nervous fyftem ; contradtion of the fmall arte¬ ries. 3. Torpor of the nervous fyftem ; contradtion of the fmall arteries ; diminiflied adtion of the heart.” Adverting then to the fubfequent phenomena, Dr. Nicholl fays, that “ thefe three ftates having exifted an uncertain time, a new order of ftates arifes. The adtion of the heart becomes increafed, increafed fenfibility of of the nervous fyftem takes place, and anlncreafed quan¬ tity of blood is received by the fmall arteries. Thefe three changes may take place in varied order; for in- ftance : the increafed adtion of the heart may firft arife : this may produce a removal of the torpor of the nervous fyftem; audit may, by increafing the momentum of the blood, overcome the refiftance which is offered by the ex¬ ertion of the contractile power of the fmall arteries to that fluid. Or, the fenfibility of the nervous fyftem may become increafed; and to this altered ftate of that fyftem may fucceed increafed adtion of the heart, and a more copious flow of blood through the fmall arteries. Or, if the contradted ftate of the fmall arteries give way, a more free and powerful adtion of the heart may follow, and the torpor of the nervous fyftem may be removed.” The ftates which produce the fymptoms of the fecond ftage of fever may, then, occur in either of the three following orders, viz. j. Increafed adtion of the heart ; increafed flow through fmall arteries; increafed fenfibi¬ lity of nervous fyftem. 2. Increafed fenfibility of ner¬ vous fyftem ; increafed adtion of heart ; increafed flow through fmall arteries. 3. Diminiflied contradtion of fmall arteries ; increafed adtion of heart ; increafed fenfi¬ bility of nervous fyftem. “ Having arrived thus far in our inquiry, let us return to the ftates which produce the fymptoms of the firft ftage of fever. Let us fuppofe a cafe in which increafed con- tradliun of the fmall arteries is the firft eftedt of the pri¬ mary caufe of fever. In fuch a cafe, the refiftance of¬ fered by thofe arteries to the current of the blood may induce an obftrudted ftate of the general round of the circulation, whence will enfue a turgid condition of the larger arterial and venous trunks, and of the cavities of the heart ; and from thefe effedts will arife an oppreffed and an over-powered ftate of the adtion of the heart. The obftrudted ftate of the circulation will lead to a turgid ftate of the cerebral blood-veflels ; which eft’edt, as well as the want of a free fupply by thofe vefl'els of blood which has duly undergone the pulmonic procefs, will induce torpor of the cerebral ftrudtures, and, from the torpid ftate of thofe ftrudtures, as well as from the diminution of the quantity of blood received by the fmall arteries, will enfue diminiflied fenfibility of the nerves in general. Thus will the feveral caufes of the fymp¬ toms of the early Jloge of fever be prefent. “ The action of the heart, at firft overpowered by the refiftance offered to the blood by the fmall arteries, and ftill more enfeebled in confequence of the diminifhed fenfibility of the nervous fyftem, may gradually become increafed. It may become increafed, poffibly, from its myn powers of contradtion having acquired an accumu¬ lation of energy during its opprefl’ed ftate, or in confe¬ quence of increafed fenfibility of the nervous fyftem ; or VOL. XIX. No. 1297. perhaps, in fome inftances, owing to a diminution of the contradtion of the fmall arteries, and a confequent dimi¬ nution of oppolition to the adtion of the heart. Should the adlion of the heart become increafed, the momentum of the blood will be increafed, and confequently the refiftance offered by the fmall arteries may be borne down ; in which cafe the freedom of the circulation will be re- flored. The removal of the obftrudled ftate of the cir¬ culation, and the diilribution of an increafed quantity of blood throughout the nervous fyftem in general, will remove the caufes of torpor of that fyftem. Torpor of the cranial brain is, in many inftances, fucceeded by a degree of fenfibility of that ftrudlure greater even than that which immediately preceded the infenfible ftate of it. This is conftantly the cafe after fleep. So alfo an in¬ fenfible ftate of the nerves in general is, in many in¬ ftances, fucceeded by a degree of fenfibility greater than that which immediately preceded the infenfible ftate. In the cafe under conlideration, then, it may happen that the torpor which prevailed in the early ftage of fever may, after it has exifted for fome time, gradually be re- folved into a ftate of increafed fenfibility. The prefence of increafed fenfibility of the nervous fyftem will be followed by increafed adlion of the heart, and by the flow of an increafed quantity of blood through the fmall arteries. Thus may thofe ftates be formed which give rife to the fymptoms attendant on the fecond Jloge of fever. “Suppofe that torpor of the cerebral ftrudlure is the firft effedt of the primary caufe of fever. Such- a ftate will give rife to general in fenfibility. The adlion of the heart will be diminifhed, and the contradtion of the fmallarteries will be increafed. The increafed contradtion of thefe arteries will, as we have feen, tend to produce an en¬ feebled adtion of the heart ; and a diminution of the ac¬ tion of the heart leads, as we have alfo feen, to increafed contradtion of the fmall arteries. Thus may the caufes of thofe fymptoms which attend the early ftage of fever he prefent. “ If the torpor of the cerebral ftrudtures, after it has exifted for an uncertain time, fubfides, and is fucceeded by a degree of fenfibility even greater in degree than that which preceded it, fuch new condition of the cerebral ftrudtures will be attended by increafed fenfibility through¬ out the nervous fyftem generally : increafed quantity of blood will flow through the fmall arteries. Thus thofe ftates will he eftablilhed which give rife to the fymptoms attendant on the fecond ftage of fever. “ If diminifhed adtion of the heart be the firft effect of the caufe of fever, diminution of the momen¬ tum of the blood will enfue, to which will fucceed increafed contradtion of the fmall arteries and tor¬ por of the cerebral ftrudtures, and confequently, a ge¬ neral diminution of the fenfibility of the nervous fyftem. And thus thofe ftates will be formed which produce the fymptoms of the early ftage of fever. “ When thefe ftates have exifted an uncertain time, if, as we have fuppofed, the heart be enabled, from changes which take place within itfelf during its ftate of inadti- vity, to adl with a degree of force even greater than be¬ fore; the momentum of the blood will be increafed, and the refiftance of the fmaller arteries will be overcome The torpor of the cerebral ftrudtures will be removed, and a preternatural degree of fenfibility of thofe ftruc- tures may arife, not only as a confequence of an in¬ creafed flow of blood through their blood-veflels, but poffibly, as we have fuppofed, as a confequence of the previous ftate of torpor. The increafed fenfibility of the cerebral ftrudtures will induce a general increafe of fen¬ fibility throughout the nervous fyftem, and will caufe the action of the heart to be ftill more forcibly exerted. Thus, in various ways, thofe feveral ftates which charac¬ terize the fecond ftage of fever will be eftablilhed. Du¬ ring the exiftence of the fecond ftage of fever, although an increafed quantity of -blood flows through the- fmall arteries, yet this increafed flow appears to arife, in the 3 F generality 200 PATHOLOG Y. generality of cafes, not from ceffation or diminution of contraiOion in thofe vefl'els, but from the increafed adfion of the heart enabling the blood to force its way into, and through, thefe arteries, in fpite of the oppofitiou which is offered by their contradfile power to that fluid. So that, in the fecond ftage of fever, there is, as it were, a continued conteft and ftruggle between the adiion of the heart and the contradlile power of the fmall arteries, the balance of power being conftantly in favour of the former. “ We now proceed to the confideration of the laft ftage, or the decline of fever. We obferve that, whenever a high degree of fenfibility of the nervous fyftem has ex- ifted for fome time, it is, fooner or later, fucceeded by a ftate of torpor, the degree of which is proportionate to the duration and the degree of the preceding fenfibility. Wealfofind that, when a high degree of adtion has been kept up for fome time by the heart, a languid adfion of that organ fooner or later fucceeds ; the degree of lan¬ guor being proportionate to the duration and the degree of the preceding ftrength of adfion. When a high de¬ gree of refiftanceto the momentum of the blood has been offered, for a length of time, by the contradfile power of the fmall arteries, the exertion of that power will, fooner or later, become enfeebled, or will be fufpended ; the diminution of that exertion being proportionate to the degree and duration of its previous adtivity. “We have traced the various ways in which thofe ftates which characterize the fecond ftage of fever may be formed. Let us fuppofe that, in either of thofe ways, thefe ftates have been produced. The high degree of fenfibility of the nervous fyftem; the high degree of ac¬ tion on the part of the heart ; the ftrong, but unavailing, refiftance of the fmall arteries, may feverally laft an un¬ certain time. The natural confequence of each of thefe liates will be, as we have juft feen, the formation of an oppofite ftate. The high degree of fenfibility will give place to torpor ; the powerful action of the heart will fub- fide into feeble contradtion ; the ftubborn refiftance of the fmall arteries will give way. Accordingly we find that thefe natural confequences are precifely the occur¬ rences which are met with in the laft ftage of fever. The fenfibility of the nervous fyftem becomes diminifhed in proportion to the duration and degree of its previous in- creafe. The adtion of the heart becomes feeble. Both thefe new ftates favour the increafe of each other. The contradtion of the fmall arteries gives way ; the ftruggle between thefe veffels and the heart is at an end, fo that the contradtion of the heart, although enfeebled, may {till be able to carry on the circulation of the blood ; and thus an obfti-adted, or a ftagnant, ftate of the round of the circulation, which would otherwife refult from the languid adtion of the heart, may be prevented. “ It appears, then, that both in the firft and in the laft ftages of fever, the fenfibility of the nervous fyftem and the adtion of the heart are diminifhed ; while, in the early ftage, the contradtion of the fmall arteries is in¬ creafed; whereas, in the decline of fever, it is diminifhed or altogether fufpended. The different ftate of the con- tradtile power of the fmall arteries, then, appears to conftitute the leading diftindtion between thecharadter of thefe two ftages of fever. From the refult of our invefti- gation, it appears that the ftates which charadterize the iecond ftage of fever are the confequences of thofe ftates which uftier in fever ; and that the ftates which confti¬ tute the third ftage are the natural refultsof thofe which are met with in the fecond ftage. It follows then that the ftates attendant on the third ftage, as well as thofe which mark the fecond ftage, are the confequences of thofe ftates which appear in the firft ftage of fever.” Before we proceed to examine the juftnefs of thefe views of fever, we (hall prefent to our readers a hiftory of thofe phenomena. It is now pretty generally acknow¬ ledged, that the divifion of the fevers of this country into fynocha, fynochus, and typhus, is not founded in nature, but engendered by hypothetical notions in the brain of Cullen. On this account we (hall proceed to fay, that, of fevers in general, the commencement is commonly marked by fome degree of languor, laifitude, and general uneafinefs; the patient feels himfelfill, with¬ out being able to refer his uneafy feelings to any parti¬ cular part of the body. There is alfoa liftleffnefs, or a defire frequently to change the pofture, but at the fame time the fenfe of wearinefs difpofes the patient to refift this inclination ; the motions when made are fluggifh, and frequent yawning and ftretching accompany the at¬ tempt. The mind is affeCted in a fimilar way ; it cannot reft upon any objeCt; the attention is not under the command of the will, but wanders from one fubjeft to another; and, as the ability of exerting the mufcular powers becomes diminifhed, there is likewife an inabi¬ lity of exercifing the faculties of the mind ; the patient cannot think or reafon, even upon his ordinary affairs, with his ufual eafe. Along with thefe fymptoms, but more frequently after them, he feels a fenfation of cold, commonly firft in his back, but afterwards over the whole body ; the fame kind of fenfation that he feels when furrounded by a colder medium than he is ac- cuftomed to: he willies, therefore, to go near a fire, or into the rays of the fun, or to put on warmer clothing. At the fame time the face and extremities are obferved to be pale, the features flirink, the bulk of every external part is diminifhed, and the (kin over the whole body ap¬ pears conftriCted, as if cold had been applied to it. This fenfation of cold varies much more in different inftances of incipient fever than the languor and laflitude before mentioned ; in fome cafes it is very flight, in others not at all felt or noticed ; whilft in many inftances, particu-' larly in the intermit’ent fevers, it becomes fo great as to produce a tremoror fhaking in all the limbs, with a chat¬ tering of the teeth and frequent rigors of the trunk of the body. In this ftate, the a&ual heat of the furface, whether meafured by the fenfations of a by-ftander or a thermometer, is confiderably diminifhed ; in the extre¬ mities in particular it is many degrees below the ftandard of health. Not only on the furface, as is generally ima¬ gined, but even over the whole fyftem, the heat is pro¬ bably diminifhed ; the air expired from the lungs feels cool to the back of the hand, held near the mouth. Dr. Currie ftates, that he has found the heat under the tongue, and at the axilla, as low as 94, 93, and 92, de¬ grees of Fahrenheit’s thermometer. (The healthy tem¬ perature of the human body, it may be obferved, is about 98° of the fame thermometer.) Dr. Fordyce affirms, that 940 was the loweft degree of heat that he had witnefl’ed under the fame circumftances. (Firft Diflertation on Fever, p. 40.) The fenfations of the pa¬ tient, however, do not always correfpond with the ac¬ tual degree of cold, as meafured by the thermometer, or by the fenfations of others ; for it has been remarked, efpecially towards the termination of the cold ftage of the fever, that the patient feels himfelf cold, even on thofe parts of the body which are fhown, by the applica¬ tion of a thermometer, to be of the natural heat, or even hotter than they ufually are in health. With this ftate of coldnefs, the fenfibility of thebody is confiderably di¬ minifhed; all the fenfations, but efpecially thofe of touch and tafte, are lefs accurate and diftinCt than in the healthy ftate. Dr. Fordyce remarks, that, “in the attack of fe¬ ver, fuch a degree of infenfibility, with a feel of coldnefs, has in many cafes taken place, that even hot fubftances have been applied in fuch manner as to coagulate, nay perform the chemical analyfis of the part, without any fenfation of heat having arifen in the mind of the pa¬ tient.” (Loc. Cit. p. 49.) The diminution of the fa¬ culty of fenfation is very various in different inftances of the attack of fever. Upon the firft approach of febrile languor the pulfe is not always altered in refpeCt to frequency, but it always becomes weaker than before j fometimes it is alfo flower than 201 PATHOLOGY. than in health for a fliort time ; but, as the fenfe of cold increafes, it becomes fmaller, and gradually more and more frequent, and often irregular. While the con¬ tractions of the heart and arteries are thus feeble, all the fecretions of the fyftem are likewife diminifhed. The tongueand mouth becomedry and clammy,in confequence of the diminifhed fupply of faliva and of the mucus of thofe parts ; the fkin alfo becomes dry, as well as pale and cold, there being little or no matter of perfpiration poured out. The changes in the urine are Itill more re¬ markable ; the impaired adfion of the fecretory veffels of the kidneys is evinced by the diminifhed quantity of the urine at this period of fever, as well as by the palenefs of its colour, in confequence of its holding lefs of the mucilaginous and faline parts in folution than in health, and by the abfence of any cloudinefs or depolition when it cools. There is generally alfo a fmaller quantity of feculent matter evacuated from the inteftines at the commencement of fever, or in other words a degree of conftipation, which implies a deficiency of the fluids fe- creted from the inner furface of the alimentary canal, as well as of the bile and pancreatic liquor, by which the fseces are rendered more liquid and moveable, and the bowels are ftimulated to attion. Analogous to thefe changes in the ftate of the fecretions are the fudden and conliderable detumefcence of fwellings, which may happen to fubfift on the furface of the body, and the drying-up or ceffation of the difcharges from ulcers and wounds, during the cold ftage of fever. The refpiration alfo fuffers fome change in the attack of fever, being often (hort and frequent, and fometimes attended with a cough, more particularly in intermittent fevers. There is at the fame time a great anxiety, or a fenfe of weight, fullnefs, and great uneafinefs, in the bread. This diftrefling feeling, which has been thought by fome phyficians a pathognomonic fymptom of fever, and hence denominated febrile anxiety, is totally different from, and independent of, the general uneafinefs all over the body, which was before mentioned, and often occurs in a very difproportionate degree. It refembles that anxiety which takes place from grief, fear, and other de¬ prefling paflions of the mind, and which is alfo accom¬ panied by palenefs, and diminution of iize of the veins which are feen on the furface. The patient likewife re- fpires irregularly, as one under the influence of the paflions j u ft noticed, and frequently fighs deeply, as if to free himfelf from the load that opprefles the region of the heart. At the beginning of the attack of fever, fometimes as the very firft fymptom, but often later, a dull pain is felt in the fmall of the back, which feems to occupy the lumbar vertebra;, but is not accurately referred to any particular point. It is very fimilar to the pain which arifes from weaknefs or fatigue ; but, unlike that, ac¬ cording to Dr. Fordyce, it is equally felt in the hori¬ zontal as in the credit poflure of the body. The head at the fame time is affected with pain, which is commonly feated in the forehead over the eyes, and feels to the patient as external; fometimes it likewife occupies the back part of the head ; and occafionally it is felt all round the head. It varies much in degree, but com¬ monly increafes as the attack proceeds ; it is ufually at¬ tended with a fenfe of weight, and is often augmented by light falling upon the eyes. A fimilar pain generally arifes all over the body, which the patient often defcribes as feated in all his bones, without being able to parti¬ cularize in what part of the body it is felt. Sometimes it is more particularly confined to the larger joints ; and it is occafionally attended with great forenefs, as from over-fatigue. Such forenefs, however, is more com¬ monly confined to the fubfequent periods of the difeafe. From the commencement of the attack of fever the natural funttions are always deranged. The changes in the appearance of the tongue are among the firft indica¬ tions of this derangement. At firft the tongue appears to be thinly covered on its upper furface with an extreme¬ ly vifcid fluid, efpecially in the middle and towards the root, the edges and point being nearly free from it. The under furface of the tongue, below the point, is fcarcely ever covered with this matter. Sometimes, at the very beginning of the diforder, the covering of the tongue is a folid cruft of a whitifh colour, adhering fo firmly as to be incapable of being (craped off; fometimes it verges towards a brown colour. At the approach of the cold ftage of fever the ftomach is commonly affected; the appe¬ tite for food ceafes, and averfion even to the fight or fmell of meat often takes place. Dr. Fordyce remarks, that he “ has known feveral inftances where perfons, fitting down to the table with a ftrong appetite, an attack of fever having fuddenly taken place, in lefs than two minutes they have been unable to eat any thing, and have been feized with perfedt averfion even to the fmell of food.” (Loc. cit. p. 93.) Sicknefs at the ftomach often comes on at the firft attack, and this is increafed occafionally to fuch a degree as to produce vomiting. More common¬ ly, however, this does not take place at the very com¬ mencement ; but the difinclination to food increafes gradually to naufea, then to vomiting, which in fome cafes is very fevere, not only the contents of the ftomach being- evacuated, but likewife thofe of the duodenum, and of the glands, the fecretory ducts of which open into it. Bile, therefore, and the pancreatic juice, are thrown up, together with the contents of the ftomach, and the other fluids fecreted into the ftomach and duodenum. Of thefe fluids, however, the bile is the raoft confpicuous from its colour, tafte, and fmell; and it has therefore often been obferved by practitioners, while the gaftric and pancreatic anil other juices fecreted into the duodenum, as they are not very confpicuous from their fenlible qualities, have not been taken into the account. Combined with the fick- nefs and averfion to food, there is generally a confiderable degree of third.. Few other fymptoms, which are obfervable at the com¬ mencement of fever, remain to be mentioned. The ftate of the countenance is very peculiar and characteriftic, from the moment of the attack. It not only becomes pallid, or of a dirty hue, in common with the reft of the furface of the body, but it affumes an expreflion of dull- nefs or heavinefs, partly in confequence of the languid action or relaxed condition of the mufcles of the face, and partly from the fame condition of the mufcles of the eye-ball, by which ifs form and motion are altered, and its ufual brightnefs and quicknefs are impaired. The difpofition to deep is diminiftied or loft; or, if it occurs, the repofe is (hort and interrupted, and very im¬ perfect, fo that there is much dreaming, during which the ideas that prefent themfelves are nioftly of an un- pleafant kind. When the fenfation of cold, and the attendant fymp¬ toms, have continued for fome time, (the period being- very various in the different kinds of fever,) the cold becomes lefs violent, and is alternated with flufhes of heat. In the more fevere continued fevers, it frequently happens that the cold is not permanent for any length of time, but that this alternation of chills and heat takes place from the beginning. By degrees the cold goes oft entirely, and a heat greater than natural is extended, at firft unequally in different parts, but at length generally over the whole body ; but even when it is fo far advanced , that the heat, meafured at the axilla or under the tongue, is greater than the ftandard of health, a (light acceflion of external cold will produce a general chillinefs. There is no regularity in the reftoration of the heat to the furface ; in fome parts the heat is above what is natural, while in others it remains below this ftandard ; and hence arifes that mixed fenfation of cold and heat, which every one acquainted with fever has experienced, in the tran- fition from the cold to the hot ftage of the paroxyfm. This inequality of the diltribution of the heat is lefs in the Ampler forms of fever, and greater in thofe which are PATHOLOGY. *202 are more complicated and irregular. In general the fenfe of cold predominates, even after a morbid heat has taken place at the axilla, under the tongue, and in diffe¬ rent parts of the thorax and abdomen. Atlength, how¬ ever, the heat of the furface becomes general and uni- tonn, riling to 102, 103, 104, and fometimes 305, of Fahrenheit’s thermometer. Different authors indeed fpeak of febrile heat four or even five degrees higher than this ; but fuch heat never occurred under the obfervation of Dr. Fordyce or Dr. Currie, the beft authority on this fubje£l : Dr. Bateman alfo had frequently employed the thermometer, in cafes of continued fever, and never oB- f'erved a higher temperature of the body than 104 in intermittent or continued fever, the patients being in cool apartments, with very light bed-coverings. The fenfa- lion of heat becomes at length ftrong and Heady, and the accefiiou of external air does not produce a return of chillinefs as before; this ferifation is moll powerful in the extremities, particularly on the palms of the hands and loles of the feet. The increafe of the circulation takes place at the fame time as the returning heat, and often in the fame unequal manner, being evidently greater in fome particular parts than in others. Thus it frequently happens, that one part lhall become red and enlarged, one arm, for inftance, while the other is pale and contracted ; the veins of the one being full, and the blood flowing in them more ra¬ pidly, while thofe in the other remain contracted. This lhall continue for fome time, when the parts become af- feCled in the oppofite way ; the arm which was florid and diftended becoming pale and contracted, and vice verjd. This fhifting, however, remains but a fliort time in Jimple fever, perhaps not above half an hour ; in the paroxyfms of intermitlents it continues longer, and (till longer in the firft attack of continued fever. Univerfal rednefs at length takes place; the features of the face and other parts of the body recover their ufual fize, and become even more turgid ; and the fuperficial veins evince the greater cir¬ culation now going on through them by their fullnefs and increafed fize. The fkin is relaxed and fmooth, no longer exhibiting the goofei-flein appearance by its con¬ traction round the little glands and roots of the hair; but it continues for fome time dry. The pulle now be¬ comes f uller and ftronger, and its frequency continues or is Hill farther increafed ; in Ample fevers, it beats oc- cafionahy at the rate of 140 or 150 llrokes in a minute, wjth a confiderable degree of fullnefs and hardnefs (Fordyce) ; but in the hot llage of intermittents, and in the heat of continued fevers, it is moll commonly from 90 to no at this early period of the difeafe ; fubjeCl, however, tp great variation according to the conllitution of the patient, and the type of the fever. The refpira- tion, though more free than during the chillinefs, conti¬ nues llill frequent, and accompanied by a fenfe of load and anxiety, which the patient endeavours to remove by occafional laborious efforts, and deep fighing. The fe- cretions Hill remain diininifhed; the the mind, neverthelefs produce fometimes erroneous im¬ preffions. Thus the patient can fee, but he millakes ob- jedls ; he fancies one individual is another, or that a man is a poft : and his organs of hearing, which are alfo more readily affedled, do not convey the fame perceptions which the fame founds would excite in health. The fame thing happens with regard to his other fenfes. All the fymptoms above enumerated increafe from the fecond day of fever. The tongue grows more foul, and the cruft which forms upon it thicker, until the middle of the fecond week. Towards the end of the fecond week this cruft often difappears more or lefs, and the furface of the tongue looks raw when moift, and when dry has a polilhed glaze, efpecially about the middle, fome of the cruft remaining upon the fides towards the edges. Before thefe fymptoms, however, have advanced to tile degree 203 PATHOLOGY. degree juft defcribed, and after the general heat has con¬ tinued for an indefinite time, (in the ephemera] and in¬ termittent fevers a few hours, in continued fevers feveral days,) it often happens, that a partial moifture begins to appear on the fkin, generally on the forehead, which ex¬ tends gradually downwards to the neck and breaft, and at length a free fweat takes place from the whole furface of the body. At the fame time the fymptoms of the firft ft age of the fever begin to abate, fometimes one giving _ way firft, and fometimes another, fo that it cannot be faid which has the priority : fometimes the weight and anx¬ iety about the prascordia are firft obferved to diminilh, fometimes the change of the pulfe from hardnefs to foft- fiefs is the firft obvious amendment, and fometimes the relaxation of one or other fet of fecretory veffels, See. Such a change of the fymptoms, terminating fpeedily in a reftoration of the health, has been called, by a term borrowed from the Greek, a erifis ; and the excreted fluids, which are poured forth at the time of this change, have hence been denominated critical difeharges. The moll linking appearance, both to the patient and by- ftander, is the perfpiration, which is frequently carried to the extent of profufe fweating in internments and the Ampler forms of fever, but fometimes amounts only to gentle moifture. While the fweating continues, all the fymptoms of the previous ftages abate s the preter¬ natural heat is gradually diminilhed ; the pulfe becomes fofter and lefs frequent; the breathing is likewife frequent, and more free, and is unaccompanied by fighing ; and the anxiety and heavinefs in the cheft are greatly alleviated. The head-ache gradually goes off, and" the pains of the loins and extremities ceafe ; the naufea and vomiting no longer diftrefs the patient, who now acquires a relilh for light nourifhment; the thirft is removed ; the mouth and tongue become moift, as the falivary and mucous glands pour out their fluids, and the tongue becomes gradually clean, firft upon the edges, afterwards in the middle and ®H&r the root ; the cruft, which had formed upon it, coming off in fmall flakes, until the whole furface is in its ordinary ftate. The fecretions of the liver, pancreas,, and inteftinal glands, being reftored, the bowels begin to' aft, and the evacuation from them comes to its ordinary quantity. A loofe ftool is commonly paffed at the end of a paroxyfm of intermittent fever ; and fometimes a diar¬ rhoea comeson in continued fever, and, being the molt ob¬ vious, is then confidered as the critical difeharge. The urine generally undergoes fome peculiar changes in the erifis of fever: it is not only fecreted in larger quantity, but, although bright and tranfparent when difeharged, if allowed to remain for fome time it is obferved to grow turbid, as if containing a quantity of a yellowilh-red powder, and at length to depofit flaky cryftals of a dirty red colour, commonly termed a lateritious fediment. Tumours, which were diminilhed during the cold, and more painful in the hot, ftage, return to their ufual fize during the fweat, and ulcers again begin to difeharge matter. Theintelleftnal funftions are alfo reftored during the erifis ; the attention of the patient is no longer ab- forbed by his uneafy feelings, the confufion of his head is relieved, and he is not ha raffed by the perpetual re¬ cti rre nee of diftrelfing images to the mind, efpecially in his (lumbers ; a difpofition to calm deep returns; and the countenance relumes its natural expreflion. It was remarked by Hippocrates, and the majority of the ancient phyficians, that tliefe crifes occurred more frequently on particular days of the fever, which they, therefore, obferved with great care, as affording both particular indications in praftice, and the means of prognofticating the phenomena of the fubfequent periods of the difeafe. Hence they called thefe days critical days. Tliefe periodical changes, happening on particular days, are however feldom diftinftjy noticed in this country ; they feem to occur more decidedly in warm climates, where all fevers have a greater tendency to affume the Vol. XIX. No. 1297. remittent form. Dr. Cullen, who believed that even in this country thefe critical days were obfervable, though lefs diftinftly than in hot climates, explained their occur¬ rence upon the principle, that continued fevers were in fome degree difpofed to take on the types of intermit¬ tent’s ; and in this principle he has been followed by Dr. Fordyce. (See Cullen, Firft Lines, § cxix. Fordyce, Third Differt. on Fever, p. 120.) But it mull be re¬ marked, that the doftrine of critical days, as taught by Hippocrates, was ridiculed by Afclepiades and Celfusp who praftifed in the fame climate with Hippocrates, and in the fame city with Galen ; and Herophilus altogether denied its truth. In this country, and in cold climates in general, con¬ tinued fevers are feldom terminated by erifis. Some praftitioners have maintained, that a erifis never takes place, whilft others have infilled that crifes happen in all continued fevers. Dr. Fordyce juftly remarks, that thefe extremes of opinion are both inconfiftent with cor¬ rect obfervation. It is admitted, however, that crifes occur much lefs frequently in this climate than in hotter countries ; and we think that the phyfician juft men¬ tioned confiderably over-rated the proportion when lie fays, that “ not above one-third part of the fevers which happen in London are terminated by a erifis.” (Loc. cit. p. 126.) We believe the proportion to be very far below this ftatement. In the great number of inllances of fever, no erifis takes place 5 but the difeafe terminates in a more flow recovery, or in death. The fymptoms before enumerated increafe gradually to the end of the firft, or middle of the fecond, week ; fometimes by the feventh day the fymptoms have at¬ tained their greateft feverity ; fometimes, too, the fecond week is gone through without very fevere fymptoms, and in other cafes fymptoms of the greateft diftrefs and danger then occur; and there are all gradations between thefe extremes. The appearances in the fecond week, when the fever is not extremely fevere, are often as fol¬ lows. The pulfe is frequent, beating from 100 to 120 in the evening, and in the morning fomewhat lefs; the Ik in continues dry and hot, in various degrees; the tongue is covered with a brownilh fur; the appetite is often totally loft; thirft continues, but is often com¬ plained of lefs during the fecond than during the firft week ; and the depreffion of ftrength is confiderable. The deep is difturbed and fiiort, and the delirium is ma- nifefted in the intervals by the incoherence of the obfer- vations of the patient, until he is completely roufed by fome ftrong imprelfion on the fenfes. In the morning the delirium is lefs than in the early part of the night, and the deep fometimes tolerably quiet ; even during the day there is confiderable confufion, and occafionalSy much flownefs of intelleft. Hence perhaps the thirft, as well as the head-ache, and pains of the back and limbs, are lefs complained of, rather than from aftual relief or diminution of thefe fymptoms. The eyes have a dull and confufed appearance, and commonly fome degree of red- nefs, from a number of fmall veffels diftended with blood. Sometimes a degree of ftupor comes on in tire morning, and continues till the more aftive delirium of the night. If this ftate (hould remain. Dr. Fordyce ob- ferves, till about the fourteenth day, the evening attacks become by degrees lefs, but the ftupor continues, with deafnefs, and inattention to external objefts ; and thefe appearances remain the very laft fymptoms of the difeafe. Very frequently about the end of the fecond week, and often fooner, the fymptoms begin gradually to diminilh in feverity. The firft appearance of this abatement is not uncommonly a cleannefs and healthy look about the edges of the tongue ; fometimes, although not very generally, fweating takes place all over the body, and the Ikin afterwards continues moift; more commonly the moifture and foftnefs of the Ikin appear in a lefs marked manner. The delirium abates altogether in the day, and 3 G returns 204 PATHOLOGY. returns lefs feverely at night; or, if the patient be deaf with fome ftupor, rhefe (ymptoms are little changed in the twenty-four hours, but remain until the whole of the difeafe has difappeared. The deprefiion of ftrength goes oft, but leaves real weaknefs behind. 'I'he urine depofits fometimes a copious lateritious fediment for a^day or two, and afterwards returns to its natural appearance. Sometimes there is a copious lateritious fediment in the urine made in the night, and a mucous one in that made in the dav-time. The coftivenefs goes off, and the fseces" return to their ordinary appearance ; and all the fecre- tions become gradually increafed, not equally, but fome¬ times one more fpeedily, fometimes another. The eyes, unlefs when the delirium has ended in ltupor, begin to have a more healthy appearance, are more compofed and clearer, and exprefs a greater attention to the objefts around them. The deep returns, but not equally; the patient fometimes palling a quiet, at others a re file Is, night. The appetite returns, although feldom regular¬ ly ; fometimes it is voracious, but the patient is not- w’ithftanding fatisfied with a very fmall quantity of food; in the other cafes it returns very flowly. Although the deprefiion of ftrength fometimes goes off altnoft at once, yet it leaves the patient often with a greater feeling of weaknefs. Thus, however, the whole difeafe difappears, and the patient recovers his ftrength very quickly. But, although this favourable termination of fever oc¬ curs in a large majority of inftances in this country, it is neverthelefs a difeafe frequently fatal, and, under parti¬ cular circu mftances, the caufe of great mortality. When fever terminates fatally, the fymptoms prefent themfelves chiefly under two different afpefts, but varioufly modi¬ fied, approaching to each other, or even partially com¬ bined. The individual varieties it is impofiible to depift; a knowledge of them can only be attained by perfonal obfervation of numerous cafes at the bed-fide of the lick. One of the forms, juft alluded to, confifts principally of a great aggravation of the fymptoms of the hot ftage. The heat of the fkin continues great and pungent, and its fur- face dry and parched ; the countenance is Unified, and the eye fuftufed with rednefs, and intolerant of light; the head-ache is fevere, little or no fleep is obtained, the de¬ lirium is augmented, and is accompanied with extreme reitlefinefs, often with vociferation, and even great muf- cular ftrength, fo that the patient is with difficulty con¬ fined in bed ; and the pulfe is frequent, with confiderable jhardnefs. About the end of the fecond week thefe fymptoms fuddenly change ; the delirium ends in an in- diflinffnefs or confufion approaching to ftupor, the arti¬ culation becomes indiftindi, the breathing laborious, the ftrength finks rapidly, cold l'weats and convulfive motions enfue, and the patient is cut off in a few hours. Some¬ times fymptoms of inflammation of the lungs fupervene, and, continuing together with the delirium, hot fkin, fre¬ quent pulfe, and brown tongue, the patient dies with fymptoms of fuffocation ; and fometimes inflammation of the inteftines, or other important organs, being l'uper- added to the original fever, accelerates and modifies the fatal termination. This has been called inflammatory fever. The other form of the difeafe, above mentioned, is extended more commonly to the third week, fome¬ times later, and the progrefs of the fymptoms is more gradual. The deprefiion of the mufcular powers conti¬ nues to increafe with the difeafe : the eyes become funk, dull, and liftlefs ; the countenance dejeffed, and of a dufky hue ; the delirium is attended with a low mutter¬ ing, and the patient lies without the difpofition or the power of making any exertion, or he picks the bed¬ clothes; the tongue becomes crufted with a dark-brown or black matter, a fimilar fordes colledts upon his teeth and lips ; the pulfe is frequent, beating from izo to 130 times in a minute, and is at the fame time fmall and feeble; the refpiration is alfo weak, generally frequent, and interrupted with fighing or a dry cough ; the voice becomes indiftinft or inarticulate; and there are flight convulfive twitches, or fubfultus tendinum. At length the proftration of ftrength becomes extreme; the patient lies on his back, being unable fo fupport himfelf in any other polition, and even Aides down towards the bottom of the bed ; he is altogether infenfible to external im- prefflons ; the fphindters, as well as the mufcles of vo¬ luntary motion, are relaxed, and he pa fifes his ftools and urine involuntarily in bed ; the pulfe becomes very feeble, tremulous, and fcarcely to be felt at the wrift; partial clammy fweats break out ; the eyes appear glazed and fixed, and the other features fhrink ; the patient is unable to fwaliow ; his breathing becomes irregular and labo¬ rious, attended with fome noife in the throat, as the fatal event approaches; the extremities grow cold ; and, often after fome. hours, the functions of life finally ceafe. When fever affumes this form, it eonftitutes typhus , or the nervous, malignant, Sec. fevers of authors. There are fome other appearances, which, though not the ordinary attendants on fever, occafionally occur, ef- pecially when the difeafe is of a fevere kind, and which have been confidered as evidence of malignancy, or of putrefcence. Generally in the fecond week of the dif¬ eafe, but fometimes as early as the fourth or fifth day, (fee Pringle on Difeafes of the Army, part iii. chap. 7. and Huxham on Fevers, chap, vii.) an eruption of fpots, not elevating the cuticle, of a red colour, fometimes pale, often darker, or even of a livid or purple hue, appears on the fkin: thefe fpots, or pelechice, are thickeit on the breaft anil back, lefs numerous on the legs and arms, and are feldom, if ever, feen on the face. They were firft defcribed, among the moderns, by Ingraffia of Naples, afterwards more particularly by Fracallorius, under the names of lenticula, punSlicula, or peticula; whence alfo the fame appellations were given to the fevers themfelves. (See Fracaftorius de Morb. Contag. lib. ii. cap. 6.) Pe¬ techias appear in fever, moll frequently in clofe and crowded fituations ; formerly they were very frequent attendants on the fevers which occurred in the perfons under confinement in clofe cells, or crowded apartments in our prifons. Dr. Willan has ftated, however, upon the authority of the furgeon of Newgate, that, fince a ge¬ neral attention to ventilation and cleanlinefs has been adopted, petechias do not now appear in more than one cafe of fever in thirty in that prifon. He has alfo added, from the obfervation of Dr. Bateman, phyfician of the Fever Inftitution in London, that the proportion of cafes, in which petechiae occur in that inftitution, is about one in forty-two. (See Willan on Cutaneous Difeafes, order iii. p. 468.) Sometimes the purple fpots are of a large fize ; in which cafe there are often alfo livid blotches, or Itripes like the ftrokes of a whip, vibices, and haemorrhages, break forth from the internal parts, as the bowels, lungs, fto- mach, and wherever the furface is covered with a very thin cuticle, as from thenoftrils, thegums and mouth, & c A rafh of a different fpecies, which Dr. Willan has termed rofeola, “a rofe-coloured efflorefcence, varioufly figured, without wheals or papulae, and not contagious,” (Loc. cit. order iii. genus 4.) fometimes makes its appear¬ ance in fever of the typhous type : fometimes it precedes the formation of purple fpots and vibices, and in other cafes it is feen early in the fever, but remains only for a fliort time without any material confequences. Some other cutaneous appearances occafionally occur, as men¬ tioned by Huxham, (Loc. cit. p. 97.)'fuch as miliary puftules, a fcabby eruption about the lips and nofe, and aphthae. We have thus laid before our readers an ample account of the phenomena of fever, in order that the relation be¬ tween tliofe phenomena and our explanation of them may be more clearly feen. We proceed to examine the merits of the gaftric theory of fever. In the firft place, the afler- tion of Broufiais, that a furred tongue and other appear¬ ances of the mouth indicate inflammation, by no means refts 205 PATHOLOGY. r&fts on a (table foundation, becaufe thofe difordered fe- cretions may be the refult of difturbance in the brain. It mult be granted, however, that the red appearance of the edges of the tongue, a fymptom this author particu¬ larly dwells upon, is a fign of inflammation ; but every one knows that this fymptom is often wanting in fevers; and, that all other appearances of the tongue may be produced by nervous irritation, altering the fecretion on the furface of that organ, is clear enough, from the ob- ferved and well-known effefts which the artificial inter¬ ruption of nervous power to a fecreting furface invariably occafions. Now that inflammation of the mucous mem¬ brane itfelf may produce the various appearances of the tongue in fever, we cannot admit, becaufe local applica¬ tions, known to be capable of bringing on inflammation, do not caufe the difplay of fimilar appearances. More¬ over, if it were allowed that inflammation of the mucous membrane do exift, it were (till impoflible to (how by what influence general febrile commotion is produced ; becaufe inflammation in one part mull be the fame as in another to a certain-degree ; and hence fever might re¬ fult from inflammation of any organ of the body without implicating the digeflive tube, which does away with the theory. The effeft of ftimulants and tonics in fever does not require us to believe this theory, fince the intimate fympatby between the ftomach and brain offers a ready explanation of the faft. Independently of this, a few cafes have occurred in debilitated and generally-difeafed patients, in whom the exhibition of gentle ftimulants has produced highly favourable confequences. The ftrongeft faffs adduced in favour of the doftrine of Broufl'ais, is the red appearance of the infide of the ftomach on diffeftion, becaufe his opportunities for car¬ rying on diffeftions of that kind have been almoft un¬ limited ; but we think whoever attends to the clafs of patients from whom thefe diffeftions were made, and the climate they exifted under, will have no hefitation in be¬ lieving, with us, that this author has been led to form this fweeping conclufion as to the general fources of fe¬ brile ailments from having principally had under his care the gaftric form of fever, i. e. a complication (very fre¬ quently met with) in which the ftomach, fometimes fole- ly, fometimes in common with other organs, is in a (late of phlogofis. We have feen patients who have died of fever, in whom rednefs of the mucous membranes in the ftomach was not found ; and, though our very limited experience would feebly indeed counterbalance that of a Broufl'ais, we conceive that a very few unequivocal cafes overthrow the whole theory as to the effential caufe of fever. We have no hefitation in contradifting Dr. Harrifon’s affertion, that the intenfity of fever is in direft ratio to gaftric inflammation. We deny this from diffeftions ; and we leave this and the above affertion, which we have made in oppofition to Broufl’ais, to be corroborated by the experience of our medical brethren. It muft be granted, after all, that gaftritis in various degrees of feverity, though ufually mild, is (rnoft pro¬ bably from the fame caufe which produces heat and red¬ nefs of the external (kin) a frequent concomitant of con¬ tinued fever; and that it always exifts in the Exanthema- ticae, or eruptive fevers. It will be feen, that Dr. Nicholls’s rationale of febrile phenomena is principally derived from the application of the two laws, that diminiflied fenfibility is followed by excefs of fenfibility, and the fame of contraftility (or, as he ftyles it, tonicity). The extenfive and accurate man¬ ner in which he has traced their operation in the long quotation we have given, will fave us from pointing them out further. It will be feen, however, that this author by no means enters into thofe queftions which the majo¬ rity of writers have contended about, and which we have before detailed. There are moreover many conclufions ftated of which Dr. Nicholls has adduced no proof; as where he fays, in fpeaking of the firft ftage of fever, that fulnefs of blood in the head will arife from want of ac¬ tion in the heart ; and it is on this affumption that many of his reafonings turn. Upon reviewing thefe various theories of fever, not one of which has maintained altogether its ground, we neverthelefs fee much to admire; and we (hall now pro¬ ceed to cull the good parts of each and exhibit them in what appears to us to be the moll: Ample form. We (hall firft pa fs in. review the caufes of fever. Thefe are of three kinds: inflammations of all parts ; animal irritants, or contagious effluvia; and vegetable irritants, or marfh miafmata. A predifpofition of body is required to ena¬ ble thefe agents to produce the febrile ftate, fince all are not equally liable to undergo their operation. The ftate of body which feems to be moll: liable to be affefted by fympathetic fever, or that from local inflam¬ mation, is plethora ; though it is to be remarked, that this does not argue that fymptomatic fever is in plethoric habits the molt formidable. The ftate of the body which difpofes to the influence of contagion and miafmata, is a weakened condition of the nervous fyftem. Thus cold, bad living, fatigue, the depreffing paffions, Venus nirnia,' have long been accounted predifpofing caufes. They are alfo in conjunction, or long applied, exciting caufes, and will produce fever without contagion. From thefe well-known and generally-allowed ftate- rnents it follows, that the operations of febrile commo¬ tion is carried on through the medium of the nervous fyftem ; a faft long fince fliown by Cullen and others, but of which we have been long in making a proper ufe in the profecution of this fubjeft. We have feen that in fever the capillary fyftem betrays the firft fymptoms of derangement, principally manifelted in the (kin. Thefe fymptoms are generally coldnefs orrigor, the confequence of conftriftion of the capillaries. Now, to this gene¬ ral c-onftriftion (as is explained by Dr. Park in his Patho¬ logy of Fever) may be referred all the phenomena of the firft or cold ftage of fever. For, every part having a dif¬ ferent mode of feeling, and a different funftion to per¬ form, it follows that various effefts will refult in differ¬ ent organs from the fame change of circulation. And accordingly, that ftate of veffels which occafions a fenfe of cold on the furface is accompanied by the fenfe of navfed in the ftomach. The fame conftriftion in the ca¬ pillary fyftem of the brain produces diminiflied perform¬ ance of the fenforial funftions; or agents direftly debi¬ litating the brain may give rife to this conftriftion over the whole furface. However this may be, the atonic (fate of the brain muft be looked to as the caufe of the languor and laflitude, the lengthened mufcles of the face, the lofs of ftrength, fainting, &c. which are the conco¬ mitants of the firft ftage of fever. To the fame condi¬ tions of nervous torpor and capillary conftriftion, we refer the feeble fmall pulfe, the palenefoof the (kin, and the fhrinking and diminution of fize in the features, and every other external part, as well as of morbid fwellings. From the contrafted condition of the capillaries the other lecretions are diminiflied, through wanting a due fup- ply of blood. The mouth and tongue become dry from the fcanty fupply of faliva ; the pancreatic juice, the bile, the mucous and ferous excretions in the alimentary canal, being diminiflied, as well as the mufcular aftion of the bowels enfeebled, the faeces are not paffed for¬ wards, and coftivenefs takes place ; the urine is not only fmall in quantity, but of pale colour. The heat of the body is dependent on the due fupply of animalized blood and nervous power, and always increafed when the ratio of thefe fluids is increafed, is now diminiflied by their diminution. The diminiflied circulation of blood in the capillaries naturally throws a larger fupply on the heart; and to this circumftance the anxiety, and^fenfe of load about the region of the heart, the fighing, yawn¬ ing, and ftretching of the limbs, as well as the (hort and dilturbed refpiration, are to be attributed. All the fymptoms, then, of the on let of fever, con- ftituting PATHOLOGY. 206 ftituting the phenomena of the cold ftage, are explicable on the fuppofition of a deprelllon or diminution of the nervous energy, however induced ; and chiefly adding by conftriCHng the capillaries, or by conftri&ion of thofe capillaries which involve the brain in torpor. In like manner, the fymptoms of the hot -ftage and the fubfe- quent phenomena, in continued fevers, are refera¬ ble to an imperfeCt recoiling, as it were, of the ner¬ vous power, and more immediately to the increafed aCtion of the heart and arteries, and of the capillary veflels.' The heat, the rednefs of Ikin, and flufhed counte¬ nance, the returning fize of the external parts, the ref- toration or even increafe of the fenfibility of the organs, are all the refult of the diflention of the extreme veflels by the red blood, as the oppofite fymptoms of the cold ftage were the confequence of an oppofite condition of the circulation. Hence the frequent forenefs of the body, which cannot bear its own preflure without pain ; hence intolerance of light in the eye, and the quick fen¬ fibility to noife in the ear, both of which increafe the head-ache, which is now more acute, and deep-feated: hence alfo difeafed parts become more painful. The quick and ftrong pulfe implies the greater force of the heart, and of the arterial aCtion ; neverthelefs the dry- nefs of the flcin, and the continued fuppreflion of the reft of the fecretions, evince the continuance of a mor¬ bid condition of the extremities of the exhalantsand fe- cernents by which their funftions are impeded. This laft circumftance has been varioufly explained. Cullen attributed it (as before ftated) to a fpafmodic contraction of the termination of the veflels ; but, as we before fhowed, it did not explain how this was pro¬ duced ; and it feemed curious that a fufpenfion of fecre¬ tions ftiould arife both in the hot and cold ftage from the famecaufe. A new explanation has been promulgated by a late author, Dr. Park. He conceives that, “ During the hot ftage of fever, that thefe mouths are clofed can hard¬ ly admit of difpute; as it feems impoflible in any other way to explain, when the veflels to which they belong are gorged and diftended with fluids, what prevents thefe fluids from tranfuding at every pore. “ In order to explain why they are thus conftriCted in the hot ftage, and to underftand the nature of thefe pa¬ tulous mouths which perform an important part in the production of both fever and inflammation, we have only to regard them in the light of fphinCters, to which they are perfectly analogous. The office of both is to re¬ tain the contents of the organ to which they belong, or to allow their tranfmiinon only at fuitable times, and in proper quantity. Accordingly, the aCtion of the fphinc- ter appears to be vicarious with that of the organ, as its office requires it ffiould be; that is, the fphinCter relaxes when the organ contracts, and, on the other hand, the fphinCter contracts when the organ relaxes. Tl^us, for example, when the ftomach is roufed to inordinate ef¬ forts of contraction by an emetic, its fphinCter, the py¬ lorus, relaxes, and bile is tranfmitted through the duo¬ denum in vomiting. When the inteftines are excited to contraction by a ftrong purgative, the fphinCter of the rectum relaxes, and faeces are with difficulty retained. When the bladder contracts for the expulfion of urine, its fphinCter relaxes, and allows the tranfmiffion of this fluid. So likewife, when the veflels of the furface fltrink, and palenefs is produced by fear, a cold fweat breaks out, and the furface becomes moift. Or, when the vef- fels collapfe from lofs of blood, the fame clamminefs of the furface attends, and is the forerunner of fyncope.; and thus tranfpiration is increafed, and not fufpended, as Dr. Cullen fuppofed, by moderate contraction of the veflels. “ On the other hand, the fphinCters and the pores alike become conftriCted when the organs or veflels to which they belong are relaxed and over-diftended. Thus, when the ftomach is diftended with food, the pylorus clofes. and fuffers nothing to be tranfmitted till the bulk of its contents is reduced by abforption. When the reCtum is over-diftended by immoderate accumulation of faces, its fphinCter contracts, and the molt obftinate conftipation is apt toenfue. When the bladderis over-diftended with urine, its fphinCter becomes conftriCted, and ftrangury is the confequence. In like manner, when the veflels of the furface are over-diftended by immoderate determina¬ tion of blood in fever or inflammation, the pores then become conftriCted, and tranfpiration is fupprefied. And for the fame reafon, the fecretion of bile is fupprefied in aCtive inflammation of the liver; and that of urine in acute inflammation of the kidneys. Thus the mouths of theexhalent veflels, terminating on the external and internal furface, appear to be governed by the fame laws, and to exhibit the fame modes of aCtion, as the fphinc- ters belonging to larger organs. In the hot ftage of fe¬ ver, then, tranfpiration is fupprefied, and morbid heat kept up by over-diftention of the veflels exciting fpafmo¬ dic conftriCtion of their mouths ; and accordingly it is to the removal of vafcular diflention that we mull look for a ceflation of that conftridion, and the return of tranfpiration.” To us, this idea of the fphinCter-like properties of the fecreting veflels appears as vifionary and gratuitous as the notion before mentioned of Cullen. Moreover, much mult, in the relaxation of fphinCters, be attributed to the form which their antecedent mufcular parts oppofe to them. At all events, this fuppofition is not required. If fecretion were a procefs dependant on the mere drain¬ ing or letting-through of certain parts of the blood, we could account well for the hindrance of fecretion on the notion of contraction in the veflels; but the products of fecretion depend on nervous influence; take away the nerves going to a part, and fecretion ceafes. Can this be becaufe fuch deprivation caufes a contraction of their mouths ? The alteration of the fecretion in fever is thus ex¬ plained. Secretion is diminiflied in the firft ftage, be¬ caufe the conftriCtion of the capillaries brings to the fe- cernents fmaller quantities of blood. It is ftill more di- miniffied, or it is altered or fufpended, in the hot ftage of fever, becaufe, the nerves being prefled on by the dif¬ tended capillaries, or the nervous power being more ra¬ pidly expended in the blood in the generation of heat, perhaps a more rapid motion in the fanguineous circula¬ tion is hindered from aCling on the fecernents. It mat¬ ters not whether the latter be diftended or contracted, or in a mean ftate : they are too fmall to receive blood ; and the ftate of its parts depends on the faculties de¬ rived from the nerves, which we fee have here loft their power. Cullen erred in confidering the hot to be an invariable confequence of the cold ftage of fever. The cold ftage may happen ; and fo great may be the debility induced, that re-aCtion may never return ; or the hot ftage may be manifefted at once, as in fymptomatic fevers and fome other kinds. The fweating ftage is produced in a man¬ ner not very well underftood. It was fuppofed by the older phyiiologifts, as Albinus, Haller, &c. that the fweat, as well as the infenfible perfpiration, is a mere exudation of the watery part of the blood through the cuticle ; hence it w\as faid to arife, in fever, from a me¬ chanical relaxation of the extreme arteries, which were fuppofedtobe fpafmodically contracted during the hot ftage. But it has been obferved by later phyfiologifts, that this opinion refpeCting the nature of the perfpiration is contrary to all analogy, and founded only upon expe¬ riments made on the dead body. The opinion of Dr. Fordyce and Mr. Crufcklhanks appears to be the true one ; namely, that the matter of perfpiration is fecreted from the blood by the capillary arteries, and thrown out on the furface by organic pores in the cuticle, (however dif¬ ficult to be difcovered,) connefted with the extremities of thefe arteries ; and that in this procefs there is not a 4 feparation ! PATHOLOG Y. 207 Reparation merely, but a new combination, as in fimilar inftances of fecretion. It has been very generally held, that the coming-on of perfpiration tends to cure fever. We do not altoge¬ ther fubfcribe to this dodtrine, though certainly fweat- ing produces a falutary refrigeration. It feems to us, however, that it is critical, rather becaufe it (hows that the nerves have relumed their functions; that it is not fo ufeful in itfelf, as in being an indication of another falu¬ tary change in the conffirution. It is to t he reftoration of the nervous influence that we refer the re-eltablilhment of fecretion all over the body; as the moiflure of the mouth, the abfence of third, the return of appetite, and the copious flow of urine. The increafe of the febrile phenomena in the hot flage towards evening, is exp! fined by the well-known f'adt, that the adtion of the heart always accelerates at that period. According to the views here taken, the actions of the nervous fyflem are efl’ential movements of the febrile ftate. When we confider that this is indeed the only one through which the general fympathy between the capil¬ laries of all parts of the body can be manifefted, we (hail readily conceive that the brain mud be the part whofe morbid condition is efl'ential to fever. Our ignorance of the ftrufture and functions of that organ, prevents us from reafoning fo haftily as to affirm with Dr. Clutter- buck, that inflammation is the condition which pro¬ duces fever. But certainly it does feem, that a perpe¬ tual fympathy being eftablifhed along nervous conti¬ nuations, a fympathy capable of cauling at their remote parts difeafe limilar to that which gave rife to it, mud in its courfe implicate in this fame adtion (inflamma¬ tion) a part where the vafcular and nervous fyftems are fo clofely united as the brain. The il 1 ult ration we have attempted feems to embrace the fymptomatic, the idiopathic, and the intermittent, forms of fever. The firft we (hall now difmifs the con- ffderation of, as appertaining to Surgery, under which article the fu bjedt will be relumed. Of the others a little remains to be laid as to the agents which produce them. Of the natural agents, i. e. the atmofpherical, the mental, or the terredrial, which are daily altering the nature and conditution ofonr bodies, we may remark, that our pre- fent knowledge renders us quite incapable of tracing or illudrating their effects. We fliall (peak therefore of contagion. An opinion has been raflily broached by fome, that, becaufe fever is often diredtly traceable to contagion, therefore it arifes from no other caufe. ’It has been v/ifely and mod impugnably anfwered, that, on this fup- pofition, the feeds of all the manifold ills which “ flefli is heir to” mud have been latently contained in Adam, and that many of them mud have laid in the fame dor¬ mant date for hundreds of generations ; as in the cafes of fmall-pox, fiphilis, &c. The more general notion, and the only one which bears the ted of reafoning, is, that contagions are produced by natural chemical changes, whether external or internal to the human body; in which latter fituation they re-produce their kind. Thus putrid decompofitions of animal fubftances, the fame procefle3 adding on vegetables, or the adtion of the fun on the earth itfelf; feem, in fome fituations, to have been each followed by a diftindt contagious fever. The contamination of the air by the breathing of many indi¬ viduals, as in clofe places of confinement or in large the¬ atres, has been followed by the fame confequences, even when the individuals inquedion were all free from infec¬ tious fever. Often, however, the fevers which follow exposure to the above-mentioned agents are not tranf- terrable from one to another, but are rendered common by the genera! influence of the exciting agent. It feems too, that fome difeafes which are not generally conta¬ gious may, under circumftances of peculiar violence and iptenfity, acquire t his property; for, on the teflimony of very eminent phyficians, phthiiis and croup have been Vot. XIX. No. 1298. Raid to be infedtious; eryfipelas is well known to have become fo on fome occafions ; and indeed we fhould not be furprifed, when we confider the multiform produdts of difeafed fecreting furfaces, that lecretions of a vola¬ tile nature fhould be generated, and that they fhould be fo related with our frame as to produce like adtions to thole whence they took their rife. But, whether in the bodies of men or out of them, this product is ame¬ nable to the adtion of the common agents of matter. We fee difeafes, which have been idly called fpecific, al¬ tering in the courfe of years their nature, — old ones loff, new ones arifing. For the horrible leprofy of the an¬ cients we in vain fearch a prototype in the medical hif- tory ofonr own time. The dreadful fiphilis which mu¬ tilated the foldiers at the fiege of Naples, is now fo changed in its charadter, that we hardly recognize it in the ancient defcriptions ; and, though fcariet fever, meafles, &c. hold on for centuries their unchanging courfe, this is no evidence againft the fadt, that many dift'ufible maladies do change by the hand of time, while ail are fubjedt (though in a minor degree) to the influ¬ ence of the fame agents which control fimilar adtions of the body when called into play by other caufes. The molt important part of our inquiry refpedting contagion, relates to the mode and circumftances of its communication from individual to individual, and of its general fpreading, with a view to difcover the means of fuppreffing it, or preventing its extenfion. This en¬ quiry is, of courfe, limited to the contagions which are l’oluble or dift'ufible in atmofpheric air; Alice it is 'ob¬ vious that the indiffufible contagions may be avoided, by Ihunning the contadf of the dileafed. And it mult be premifed, that all the febrile contagions have been found, by experiments, to be propagated according to the fame laws, and to be fupprefled by fimilar means. Whenever a contagious epidemic difeafe prevails, a very general alarm is excited, in confeqnence of a no¬ tion, that the feeds of an evil fo generally deftrudtive mulf be diffufed through the atmofphere at large; and that, if we rtir abroad, we breathe contagion at every flep. This opinion has been promulgated by phyficians of high rank and authority ; but recent obfervations have fhown that it is erroneous; thus at once removing all grounds for this unnecefi’ary alarm, and diredting our attention to thofe means of precaution and preven¬ tion which can alone efFedlually contribute to our fecu- nty- . Without entering into the long firing of authors who have fupported this opinion, it is enough to ftate Amply, that a fufficient number of fadls are now known to eftablifh the inference that the popular opinion and apprehenfion are groundlefs, and that the moil malig¬ nant contagions are never conveyed to any great diffance through the atmofphere ; but that they are, in fadl, ren¬ dered inert and harsnlefs by difl’ufion in the open air, and even in the air of a well-ventilated apartment. It is alfo eftabiifhed on clear evidence, that an accumula¬ tion of contagious matter may occur, and may undergo, from the warmth of the body, a change which will in¬ creafe its force ; fo that the ftridieft cleanlinefs in the clothes and perfon of the patient ftiould always be in- fifted on. , Contagion is capable of being contained in unventi- lated clothes. A nation Iras been exterminated by fome of its people wearing a blanket tainted with contagion ; but ventilation fo e fie dtu ally removes this, that we are in no fear of carrying infedtion from one houfe to ano¬ ther in our clothes. It may indeed hang about furni¬ ture, or it may remain for iome time in the air of a place where the accefs of frefii air is excluded. In moll cafes, the contagious eflence of feve^ remains fome days in the body before its effects are manifeft. In others, the attack is almoft fimultaneous with the recep¬ tion of the contagion. Where a fudden infedtion takes place, a dil'agreeable fenfation is excited at tire moment 3 H of 208 P A T II O L O G Y. of expofure, which different perfons have defcribed dif¬ ferently. Some have felt a (harp tafte in the mouth, as if blue vitriol were diifolving in it, but which nowafhing or gargling could remove. Others have compared the firft imprefiion to that of an earthy exhalation from a newly-opened grave, the fenfation extending down to the ftomach, fometimes exciting inftantaneous ficknefs and fflivering. Dr. Haygarth mentions that two of his pa¬ tients, who were phyficians, were infe&ed fuddenly by a fhort expofure. One of them thought that he caught the fever by creeping behind, in order to affift, his pa¬ tient; the other by infpefting morbid faeces. In both thefecales, the expofure was fuch as might probably af¬ ford a full dofe of the contagion. Dr. Lind is of opi¬ nion, that, in thefe difeafes, the dools, efpecially if very fcetid, are mod communicative of contagion; next to thefe, the breath; and, ladly, the effluvia from the body. The aftivity of contagion is not always proportionate to the appearances of malignancy in the difeafed. Some¬ times only one man in a fhip may be feized with the pete¬ chial or with the yellow fever, fays Dr. Lind, while all the red continue unaffefted. And on the contrary, fe¬ vers, of the milded defcription, fometimes fpread exten- fively. The period at which different fevers begin and ceafe to generate contagious effluvia is not abfolutely as¬ certained. It feems mod probable that in eruptive fevers there is no contagion till the eruption appears; and that contagion remains fo long as any fcab remains on the fkin. This is clearly the cafe in fmall-pox. When it is confidered, that contagion originates in ac¬ cumulated and confined animal effluvia, and is communi¬ cated either to thofe w’ho approach, or come in contaCl with the fick, or by means of fubdances impregnated with contagious matter, and in thefe ways only, the means of prevention are obvious. With refpeCt to the cafual origin of contagion, it is Scarcely neceffary to fay, that cleanlinefs and ventilation, as they preclude the confinement and accumulation of the animal effluvia and Secretions, will infallibly prevent the generation of the poifon. Where contagion exids, its farther communication may be prevented by avoiding contact or approach to the fick, and by confining the pa¬ tient to a Separate room, in which, if it be kept clean, and well ventilated, it has already been fliown that the contagion will be inert at a fhort didance from the fick ; and therefore that the neceffary attendants, and medical vifitors, will receive no injury from refpiring the air within it. In this way contagion has been prevented from Spreading in large Schools, and other places, where a number of people live together, as in workhoufes and liofpitals, of which Some examples have been already given. Dr. Haygarth’s rules for the prevention of in¬ fection, Seem to comprife all the requifite means to be adopted in houfes where contagious fever exids : they are the following. i. As fafety from danger entirely depends on cleanli¬ nefs and free air, the chamber-door of a patient, ill of an infectious fever, efpecially in the habitations of the poor, fhould never be fhut ; a window in it ought to be generally open during the day, and frequently in the night. Such regulations would be highly ufeful both to the patient and nurfes; but are particularly important previous to the arrival of any vifitor. a. The bed-curtains fhould never be drawn clofe round the patient ; but only on the fide next the light, fo as to fhade the face. 3. Dirty clothes, utenfils, See. fhould be frequently changed, immediately immerfed in cold water, and waffled clean when taken out of it. 4. All discharges from the patient fhould be indantly removed. The floor near the patient’s bed fhould be rubbed clean every day vPith a wet mop or cloth. 5. The air in a fick room has, at the fame time, a more infectious quality in Some parts of it than in others. Vi¬ fitors and attendants fhould avoid the current of the pa¬ tient’s breath ; the air which afeends from his body, ef¬ pecially if the curtains be clofe ; and the vapour arifing from all evacuations. When medical or other duties re¬ quire a vifitor or nurfe to be placed in thefe fituations of danger, infection may be frequently prevented by a tem¬ porary fufpenfion of refpiration. 6. Vifitors Should not go into an infeCted chamber with an empty flomach ; and, in doubtful circumltances, on coming out, they fflouid blow from the nofe, and fpie from the mouth, any infectious poifon which may have been drawn in by the breath, and may adhere to thofe pafflages. Befides thefe precautions, we are advifed to endeavour by gafeous agents to deftroy the contagious pabulum. The vapours of vinegar, and thofe of the Sulphureous acid, have been long ufed with fome degree of fuccefs ; but thofe of the muriatic, and ftill more perhaps thofe of the nitrous, acid, appear to be the belt antidotes to accumulated contagion. The evidence of the efficacy of the nitrous-acid fume, in purifying infeCted places and fubftances, which was a few years ago laid before the Houfe of Commons by Dr. Carmichael Smyth, was fuch as to induce that houfe to vote a national donation of five thoufand pounds to him for the difeovery. This vapour is eafily obtained, by mixing with powdered nitre a little of the ftrong acid of vitriol or Sulphuric acid ; the latter combines with the potafs, the bafe of the nitre, expelling at the fame time the nitrous acid in fumes. (See Dr. C. Smyth’s treatife on the fubjeCt.) The va¬ pour of the muriatic acid may be obtained in a Similar manner, by ufing common fea or rock fait, inllead of nitre. Where contagion has been long pent up in clofe cells or rooms, it is apt even to adhere to the walls. In fuch cafes, white- walking, with hot or newly-flaked lime, is an efficacious aid of the acid fumigations. We are Sorry, however, after all, to be obliged to ad¬ mit the juftice of a remark of Dr. Clutterbuck’s ; “that thefe modes of chemically neutralizing the conta¬ gious virus, while they lead to a falfe Security, are often quite ufelefs.” For this reafon, ventilation and cleanli¬ nefs are the chief means on which we fhould place our dependance in guarding againlt the diffufion of fever. Thefe are both meafures of fo much importance, that the profoundeft phyficians have not thought it derogatory to their dignity to enter into minute and particular di¬ rections for their perfect eftablifflment. The means re¬ quired are however obvious to the meaneft capacity. We fliall j uft quote a fhort extraCt from Dr. Jackfon, be- caufe the fad it contains is not generally known. He fays, “ In cold, damp, and foggy, weather, the free admiffion of external air might probably be injurious ; for air of that defcription is not calculated to abforb or diflipate the floating contagion. In this cafe, the ftrong heat of fire in open fire-ftoves, fo placed as to diffufe its influence into the lower layer of the atmofphere, has ap¬ peared to myfelf to be the only fubftitute for defeCt of common ventilation, and the only fure means of recti¬ fying the air that is vitiated by emanation from the bo¬ dies of living men. Heat, as aCting on the fkin, proba¬ bly operates favourably on the conditions of contagious fever; it evidently operates favourably, as exciting and maintaining circulation of air within the apartment. I here take leave to mention the circumftance that firft di¬ rected my attention to it. The wards in the barrack in Weftmoreland Fort, on Spike Ifland, which were allot¬ ted to the reception of the fick of the St. Domingo ex¬ pedition, and which were crowded to the molt extreme degree of crowding, were alfo in fome degree cooking- places ; that is, employed for the preparation of the lighter parts of diet. A large fire was neceffary : and a long grate, being filled with coals, threw out a great heat, fufficient to roaft a furloin of beef. This was the cafe in the larger wards, .where there were from forty to fifty perfons flowed on the floor as clofe as they could lie. Thofe who lay within a certain diftance of the fire gene¬ rally did well, though thefymptomsof thedifeafewereoften 4 violentj PATHOLOGY. violent ; thofe who were near the end where there was no firediedin great numbers, though the fymptoms of the dif- eafeoften appeared to be moderate. The air near the fire was comparatively light, and notoftenfive; near the remote end it was heavy, unpleafant, almoft infupportable to the tranfient vifitors. The influence of ftrong heat from fire, in a fick apartment, appeared to be f’o ufeful, at leaft fo agreeable, in the prefent cafe, that large fires were or¬ dered to be made in all the huts and flteds on the out- fide of the fort which were occupied by the fick. The air in thefe huts, though filled with fick to overflowing, was not offenfive, the progrefs of contagion was not ac¬ tive, and mortality was comparatively moderate ; in faff, on the lowed fcale. From that and other more recent experience, I am difpofed to confider the action of the heat of fire as a molt important mean of ventilation, mainly conducive in arrefting the progrefs of contagion ; the chief truft, in fadf, in damp, foggy, and Hill, weather, through which we can expect to preferve the air of hofpi- tals, as filled with febrile fick, from a dangerous vitia¬ tion.” Feveris generally fatal from the occurrence of inflam¬ mation of fome part or texture of the body ; and diflec¬ tions fliow, according to the type of the reigning epide¬ mic, diforganizations of the mucous membranes of the brain, the lungs, the liver, or other vifcera. In a few cafes, however, no topical congeftions are found ; and the patient feems to be worn out by continued exhauftion of the fundtions of the nervous fyftem. The treatment of fever naturally grows out of the hif- tory already given of its caufes, adrions, and confe- quences. We fhall confine ourfelves to a mere outline of it, from a convidlion that the peculiar varieties in character, and confequently in the treatment, of epide¬ mics, are only to be learnt by experience of the particu¬ lar fever which happens to be prevalent; or, in other words, that epidemics continually vary, as was indeed the opinion of Sydenham. For fimilar reafons we fhall omit all notice of a vaft ftore of drugs which in particu¬ lar cafes have had the merit of curing fever; e. g. yeaft, carbon, muftard, with many others which occur to us even at this moment. A diftindtionis to be made between feveras itis Ample, and as it is complicated with inflammation of particular organs. Firft of Ample fever. This requires fome dif¬ ference in treatment, according to the ftage it has ar¬ rived at ; the ftages being three ; viz. the cold ftage, the hot ftage, and the declining ftage. This divifton, it is proper to obferve, is in fome meafure arbitrary, and has no exadt relation to time : for, as the whole duration of the difeafe is extremely various, extending from a few days to as many weeks ; fo the continuance of the diffe¬ rent ftages, both individually and relatively to each other, is not lefs various ; and it becomes impoflible to aflign a determinate extent fo any one of them ; added to which, they often run imperceptibly into each other. A fuf- ficient difcrimination, however, may be made between them for the purpofes of pradtice ; which is the point of chief importance. The application of contagious virus is firft made, in the majority of inftances, to the ftomach ; and there feems good reafon to think that it remains there, and produces local effedls before it is carried into the circulation. It is probably on this account that an emetic often efFediti- ally prevents the development of the febrile movements : this remedy fhould therefore be ufed in early cafes ; and purging fhould likewife be reforted to, becaufe it is fome- times difficult to eftablifh thefe adlions in the hot ftage of fever. When the hot ftage is newly formed, it is ftill often defirable to change the order of fympathetic actions which are eftablifhed. For this purpofe, the abftraftion of blood till fainting eufues, followed by a brifk purge, will often entirely prevent a fevere fever from running its courfe. In the more fevere forms occafionally met with in fo¬ 209 reign pradlice, the meafures for arrefting the progrefs of the malady muft be peculiarly energetic. The expe¬ rienced Dr. Jackfon, fpeaking of a fevere and complica¬ ted form of fever, which he characterizes as prefenting itfelf with appearances of violent irregular vafcular ex¬ citement, and local determinations which threaten con- vulfion and apoplexy, fuffocation or engorgement of in¬ ternal organs, lungs, liver, or fpleen ; fornetimes with a ftrong, or what may be called a concentrated, general ac¬ tion, thickened and conftricled fkin,- ardent as a live coal; a condition, which threatens to fubfide by internal con- geftion, or to explode by local external gangrene of va¬ ried form, viz. petechise, ftreaks of ecchymofis, or exten- five and deep blacknefles ; — gives the following judicious directions. When a certain quantity of blood, only meafureable by the phyfician as fuperintending the pro- cefs, has been abftraCted from the arm, it is ad vi fable that the patient be ftripped naked and immerfed in a warm bath of moderate temperature, the immerAon con¬ tinued for fifteen or twenty minutes, the ikin (trongly fcrubbed with brulbes and foap while under immerAon. At the expiration of twenty minutes, the condition is to be examined with care ; and, if it be then found that the mode of adtion has not changed, that is, if the movement has not become general and equal, it will be advifable to re-open the vein, and to allow blood to flow, while the patient remains in the bath, until the objedl in view be attained : that is, until the circulation be in fome manner equalized. When that is done, cold water is to be af- fufed copioufiy upon the head and flroulders, while the lower extremities remain in the warm bath. The courfe of the difeafe will, in moll cafes, be fufpended, if not perfeftly arrefted, by the effeCt of the proceedings now' recommended; and when that is done, the body, being removed from the bath, is to be wiped dry, and laid in bed ; blifters, as means preventive of return, are to be applied to the head, neck, back, or fides, according to the predominance of the local fymptoms. FriCfion with warm oil will be ufeful ; emetics and purgatives promife the fame benefit here, after the cafe is Amplified, as in the preceding. A bolus of camphor, nitre, tartarized anti¬ mony and fnake-root, with half a grain of opium, and two or three grains of calomel, given every five or fix hours, with plentiful dilution, frequent ablution, and frequent change of bed and body linen, conduce, if the courfe of the difeafe be not totally arrefted, to maintain the movements in an equal tenor until the febrile cir¬ cle be completed, when healthy adtion may be expected to re-appear. The outline of pradtice now fuggefted, varied according to circumftances, applies to the cure of the difeafe in all its conditions. Thefe violent meafures are feldorn refortable to in private practice, nor are they generally required in the fevers of this country; fo that, if tolerably adtive bleed¬ ing and purging do not arreft the difeafe at its onfet, we let it run its courfe, endeavouring to condudt it favour¬ ably to its termination. It is well known that fome thirty years back the treat¬ ment of febrile difeafes confifted in ftimulating and ex¬ citing the body to the higheft poflible pitch. The folly of this plan has been of late feverely reprobated; but a fliadow of defence has been inftituted, on this ground ; that, as epidemics are always changing their charadter, what was ufeful and right formerly has ceafed to be fo. But this is mere delufion ; for Hippocrates, Sydenham, and Huxham, and indeed all judicious practical men, bled in fevers; nor can the nature of fever itfelf be fo chan¬ geable, as to be cured by contrary remedies, though in¬ deed its variations in charadter may require a correspond¬ ing variety in treatment. We muft therefore refer to the well-known hypothetical notions of debility, &c. the fatal pradtice of our immediate predeceflors. Bleeding is now on all hands agreed to be the chief agent in fubduing the violence of fever, though there is much difagreement as to its modus operandi, and as to the PATHOLOGY. 210 the extent to which it may be carried with fafety. Of the various explanations which different authors have given of the beneficial operation of bleeding we (hall not (peak, becaufe they will naturally be underitood from the ge¬ neral fpecnlations of the pathologifts already palled in review. According to the notions we have adopted, that a general diftention of the capillaries of the fyltem is thecaufe of fever, and that an increafe in the produc¬ tion of nervous power in the brain and fpinal marrow' is the caufie which perpetuates this diftention from one part to another, and moreover fufpends the aftions of fe- cretir.g veffels ; — bleeding mult of courfe be advifed as a meafure which relieves that diftention. If diftention be the ftate of the capillary fyftetn in fever, this ftate muft be evidently increafed by the increafed action of the heart, the vis a tergo thence derived affing as a perpetual dila¬ tor of the aft’efled veffels. The diftention is alfo of courfe increafed by the quantity of blood. Bleeding therefore relieves diftended capillaries by taking from them two caufes of their unnatural condition : firft, it takes away the quantity; and fecondly, as the adftion of the heart depends fomewhat on the quantity, it takes away the diftending force of the latter vifcus. The latter effeft is llill further increafed if bleeding be carried ad deliquium animi, or till circulation of blood in the brain be fufpen- ded. Now', deeming as we do, that the diftention of the capillary lyftem occurs alfo in the brain and fpinal marrow, and thus excites the nervous fymptoms, we con- iider bleeding on the fame ground a great and direct af- liftance to the revival of the nervous functions, and hence to the reftoration of fecretion. The benefit of bleeding is alfo to be explained on other grounds ; i. e. on. the luppofition of the increafed contradficn and dila¬ tation of the capillaries in fever. It may in fuch cafes operate by relieving plethora, the ftimulus to contradfi- iity, and by diminilhing the produdlion of nervous power, the refult of increafed circulation in the brain and fpinal marrow. Whatever fide of the .queftion we take, the propriety of early bleeding in fever is fhown. It muft be remarked, however, that a low nervous fever is often formed, in which we have no right, from the produdfs of dilfedtion or from realoning, to infer en¬ largement of the cerebral capillaries ; in which, however, a high degree of nervous irritation exifts, and in which local bleeding is alone admiffible. It is in this form of fever that counter-irritants are very ufeful. From the above conliderations the propriety of bleed¬ ing as early as poffible in continued fever muft be confi- dered fully eftablifhed. As to the quantity to be taken away, no dogmata can be laid dowm on the fubjedf ; for neither the pulfe, the fize, the age, nor the temperament, of the patient, are unequivocal guides to our pradlice. The confideration of thefe conjointly muft diredt us in general. The firft bleeding ftiould be carried on til! the patient faints. As to the propriety of repeating the ope¬ ration, the fizy appearance of the blood noticed in fever, and a certain degree of inflammation of the lips of the divided orifice in the arm, will indicate to us the affirm¬ ative; while the diminished produdlion of heat, and di¬ minution of the pulfe, will point out when it is time to difcontinue the ufe of this potent meafure. Purging at the commencement of fever is of the higheft utility ; and will often, according to the teftimony of Drs. Clutterbuclc and Bateman, cut fhort the difeafe. It (hould be excited by the moil adlive means; e. g. by cathartics of gamboge, elaterium, fubmuriateof mercury and jalap, &c. (we have generally ufed elaterium.) The excitement thus produced on the bowels relieves the fever, both by emptying the fecreting veffels, and by ex¬ citing an irritation vicarious to that exifting in the brain. As the difeafe advances, (that is, about the (ixth day,) this ftrong purging lfiould give way to milder or laxative yncdicines, the adminiftration of which (hould not be puftied further than to procure two motions in the four- znd- twenty hours. The reafon for not perfifting long in the life of draftic cathartics is left inflammation be in¬ duced of the mucous membrane of the bowels ; a circurn- ftance much to be dreaded. Digitalis is a medicine of great ufe in controlling the adlions of fever. It feems to operate in the fame way as bleeding ; viz. by diminilhing the adtion of the heart and larger arteries, it prevents the undue diftention or ex¬ citement of the difeafed capillaries. But it is a medicine which requires to be carefully watched. There is no rule to be laid down as to its ufe. We are contented, in ordinary cafes, to give from five to ten drops of its tinc¬ ture every four or fix hours; but thefe doles may be quintupled in ardent fevers of great intenfity, as we fee the Italians are in the habit of doing, not only with im¬ punity, but with fuccefs. (See p. 53 of this article.) As to the dietetic treatment of febrile patients, we have fcarcely any thing to fay. The parched mouth and nau- feating palate of the fufterers in queftion fo clearly an¬ nounce the painful violation of feelings which thofe muft have undergone who were fubjedled to the difeipline of the Brunonian fchool, that one almoft wonders that the common fenfe and prejudices of mankind did not run again!! the injurious regimen of wine and ftimulants. In the majority of cafes our patients need eat nothing; a variety of cold drinks, as barley-water, lemonade, &c. may be provided for them, and allowed in the moft unli¬ mited quantities. Acid fruits may be taken freely; and this is in general all that is defired. Should fuftenance be wifhed, thin gruel is all that (hould be allowed; for of the heating and ftimulating effects of broths, bSef-tea, See. every one is fufficiently aware. At the fame time the free current of air through the apartments in the houfes of the poor, and the removal into another room of the huddled-up and dirty furniture, are alfo indifpen- labiy neceflary. The bed-clothes, linen, &c. of the pa¬ tient, ftiould be changed at leaf! every other day; and fponging the body with water (when maternal or anile prejudices do not oppofe it) (hould be ordered. And let no one defpife one iota of thefe fimpl’e (and, when uncombined, inefficient) meafures ; for they have faved the lives of thoufands, and may be confidered (in- fignificantas they are in themfelves) among the proudeft refults which have arifen from the philofophy of the pre¬ rent age. To the cold effufion ef pecial ly we are indebted for the prefervation of many of our moft efficient veterans at a time when the ufe of bleeding was not eftablifhed. Cold applications to the head are often of much avail in the removal of the nervous fymptoms of fever. Dr. Clutterbuck thinks “they are moft ferviceable where the pain and throbbing are the moft violent, and the heat of body generally much increafed.” Where, on the contrary, the face is pale, and the extremities cold, as is often the cafe in feeble fubjedls, and in advanced ftages of difeafe, the ufe of warm fomentations to the head from time to time feems more beneficial. The laft lfage of fever is marked at once by great dif- order in, and imperfeft performance of, all the fenforial functions. The patient is nearly infenffble to impref- fions ; there is extreme proftration of ftrength, indicated by the fupine pollute, and the continual Aiding of the body towards the .bottom of the bed; together with invo¬ luntary tremors of the hands and tongue; and laftly, early delirium, followed by an almoft total annihilation of the powers of mind. The pulfe is commonly fort and com- preffible, though often with confiderable fulnefs; and the heat of the body is generally confiderable. It is in this ftage, that black fordes colled! about the mouth and teeth ; that the tongue turns black on its fur- face ; and that petechias, purple fpots, and vibices, with dark-coloured haemorrhages, are apt to occur; Succeeded by involuntary and foetid dilcharges by (tool and urine. It is to fever marked by fuch fymptoms, that the terms putrid and malignant were formerly and erroneouily applied. In former times, when perfons labouring under fever were 211 P A T H C were confined in a clofe and heated atmofphere, and when cordials and ftimulants, under the name of alexiphar- mics, were largely employed, fuch a train of fymptoms was by no means uncommon. At prefent, owing to a more judicious management of the patient, they are rarely feen. The treatment of patients under thefe cir- cumftances is difficult : little in fa£t can be done. It is to be remarked, that this Hate is never met with when proper antiphlogiftic meafures have been premifed. The patient, after having undergone their operation, always terminates his life in another manner; viz. either from a general wearing-out and exhaultion of the nervous fun&ions, or from local inflammation of a particular organ. With refpe£l to the period of this ltage at which bleeding becomes inadmiffible, this is very uncertain; for it has been often fuccefsfully performed even when the pStient appeared near his death. Dr. Clutterbuck fays that he has occafionally employed it with advantage at almofl every period up to the end of three weeks. He believes it may be fafely done at any time, as long as the fenforial fundtions are carried on in a tolerably perfedt manner; “ that is, while the external fenles are prefer¬ red, the intelledtual found, the voluntary powers merely impaired, without being disordered.” This author thinks that, contrary to what is generally fuppofed, “ the more the fenforial fundtions are dilturbed, particularly the greater the delirium, the lefs confidence can be placed in this evacuation.” The pulfe does not always indicate when it will be too late to bleed ; for in numerous cafes Dr. Clutterbuck has found it weak and fmall, when bleeding has proved of the mol decided advantage. As a general rule, it may be Hated, that, while a full and wiry pulfe authorizes us to bleed in the mol ad¬ vanced ftages of continued fever, a fmall and contradled ftate of it fhould be a veto to fuch pradtice. Hardnefsof pulfe fhould alfb be particularly attended to. Dr. Clut- terbuck thinks, when it is “ foftand compreffible, blood¬ letting is altogether inadmiffible.” In the advanced ftage of fever, bleeding fhould be had recourfe to with much caution and referve, in regard to quantity; for the lofs of two or three ounces will, at fuch time, be pro- dudtive of very marked effedts. He alfo thinks that this pradtice fhould not hinder the very moderate ufe of lti- inulants, as wine, ammonia*, &c. Upon the whole, how¬ ever, we fhould attempt very little of the latter kind of pradtice, and fhould content ourfelves with the negative pradtice of abflradting all nervous irritants, as light, found, &c. and open the bowels and excite the kidneys ; always recolledting what Sydenham fays, “ ob nimia di- ligentia medici.” It is to be recolledted, that we are not now fpeaking of thofe cafes in which inflammation and diforganization takes place in a particular organ, this being the moll frequent mode in which continued fever terminates. A determination of blood to particular organs is a very frequent occurrence in epidemic fever. Sometimes thefe determinations happen very generally, from fome pecu¬ liarity in the nature or the caufe of the epidemic ; as when we fee inflammation of the lungs an almofl; con- ftant companion of the prevailing fever ; or where in¬ flammation of the mucous membrane of the inteftines, conftituting dyfentery, prevails. Occafionally, however, while Ample fever is prevalent, the particular predifpo- fitions todifeafe which are prefent in theconftitution are manifefted by oppreffion of particular organs. As to the nature of thefe determinations of blood, we have no he- fitation in afcribing them to inflammation. It fhould be mentioned, however, that this is denied by a phyfician, the excellence of whofe defcriptions and treatment of the above difeafes forbids us to pafs over his hypothefis, which we fhould otherwife confign to the oblivion it muft.foon meet with, and for which nothing but the pradlical merits of its author has procured even an ephe¬ meral reputation. The hypothefis in queftion is that of Vol. XIX. No. 1298. LOGY. Dr. Armftrong, who confiders that congeftion of blood takes place in the veins of organs gravely aft'edted in epi¬ demic fever, and without any further diforder in the ar¬ terial fyftem than fimple excitation. Now nothing can be more bafelefs than the ftrudture of this theory. It refts, firft, upon the refults of difledtion ; that is, upon finding adtual congeftion of blood in the veins. Now the verieft tyro that ever took up a fcalpel knows that the laft adt of the arteries and the left ventricle is the propulfion of blood in the dead fubjedt, fo that the arte¬ rial fyftem is always empty, the venous fyftem full. And again, granting that an excitement of the fmall arteries exifted, and caufed diftention and enlargement of the veins; the fadl is pradtically unimportant, becaufe our endeavours mull be directed to the relief of the excited arteries, not to that of the veins, which are paffive tubes. Venous congeftion cannot, however, exift without de¬ rangement in the adtion of the heart; and if fuch de¬ rangement exifted, congeftions of the veins would exift generally ; occurrences which certainly do not happen. Many other arguments fuggeft themfelves againft this wild fpeculation ; but, as thofe we have adduced feem quite conclufive, we ffiall difmifs the fubjedt. We muft affert, however, that in no other work extant do we find fo good a hiftory, or fuch efficient treatment, of local in¬ flammation fupervening to fever, as in the work of Dr. Armftrong. From this gentleman’s work, and from that of Dr. Jackfon, we fhall principally derive the fymptoms of the following complaints. We (hall not enter into any difcuffion as to whether all fevers be of one kind ; and the .yellow fever, epidemic, dyfentery, &c. the fame difeafe, varying in intenfity, and deriving the peculiar charadter of thofe forms of dif¬ eafe from the predifpofitions which climate and other ex¬ ternal agents produce, though this feems a very probable view of the fubjedt ; but we (hall confine ourfelves for the prefent to an account of thofe complications which are met with in the epidemic fevers of this country. The molt common complication is that of fever with inflam¬ mation in the lungs and its inveftments. In this cafe, in addition to the ordinary fymptoms of fever, a permanent pain is felt in fome part of the cheft, generally acute, though occafionally obtufe ; but, in either cafe, much in- creafed by deep infpiration. There is a fenfe of weight or conftridtion acrofs the breaft. The refpiration is al¬ ways laborious ; the thorax heaves, as if under fome op- preffive load ; and the alae nafi are thrown into ftrong motion. The patient is extremely reftlefs, and has a frequent and troublefome cough, which augment's both the pain in the fide and the difficulty of refpiration, Moft frequently he cannot breathe with any degree of eafe when incumbent, but is obliged to have the trunk confiderably elevated. The features altogether indicate furprife, alarm, or anxiety ; the eyes feem prominent ; the cheeks and lips are generally of a deeper colour than natural, yet in fome cafes the face has a pale bloated ap¬ pearance. The tongue is commonly foul in the middle, and of a dark red round the edges; the pulfe is fome- times flow', full, and ftrong ; and in other inftances, quick, fmall, and weak. As in almofl: all local inflam¬ mations, the temperature of the Ikin varies a great deal in the day, and partial perfpiration are not uncommon, efpecially wdien the pain of the fide is acute. A milder form of inflammation attacks the pleura, which is often infidious and unfufpedted. If the breathing be narrowly- watched, it is obferved to become quicker and more anx¬ ious, efpecially in the horizontal pofture; and cough and uneafinefs are almofl: always excited on a full infpiration. There is alio, for the moft part, pain or forenefs in the left fide, or under the fternum, with a feeling of weight or tightnefs in the breaft, often with little pain. The progrefs of the inflammation is, however, involved in confiderable obfcurity : but it may, neverthelefs.be traced by the continuance of uneafinefs in the cheft ; by the in- creafe of the cough, dyfpncea, and reftleflnefs; by the pa> 3 1 tient's PATHOLOGY. m2 tient’s panting or breathing fliort whenever he fpeaks ; by the number of refpirations exceeding the natural amount in a given time; by the colour of the face, indi¬ cating fome impediment to the common changes of the blood in the lungs; and by the gradual increafe of the pulfe, and of the fever. When the inflammation ends in an abfcefs, the uneafinefs in the brealt abates, but the breathing becomes more laborious, and there are chilly and hot fits, with copious fweats, and great lofs of ftrength. The moll common termination, however, of inftances of this kind, is by an effufion of ferum into the cavities of the pleura. This calamity is not neceffarily fatal at once, fome patients lingering for fome time afterit. In this form of difeafe, the treatment of fever in gene¬ ral mull be conjoined with the ufual means for alleviat¬ ing local inflammation. It is feldom an accurate diag- nofis can be eftablilhed between inflammation as it affeCts the fubftance of the lungs, or as it affe&s the pleura. In either cafe bliftering may be confidered a meafure of great effeCt ; and, if there feems Itrong evidence of the exiftence of inflammation in the pleura, we may have recourfe more freely to the lancet than under ordinary circumftances. It is to be remembered that cold affulion is by no means to be allowed when the lungs are affedled in fever. The warm bath is often, however, of great ul'e when the temperature of the Ikin is unequal; and at the fame time diaphoretics are of much importance. Of this kind of medicine, large dofes of calomel, with as much opium as will counteract the purging property of the latter drug, are the molt advantageous. Another complication fomewhat analogous to the pre¬ ceding, is that of fever with bronchitis. The fever in this cafe is attended with a cough, at firft dry, but after¬ wards moift. In recent cafes the expedforated matter re- fembles the white of an egg, but in a more advanced ftage it appears vilcid and opake. The pulfe through¬ out is feeble and quick, the tongue foul, the heat variable, the bowels irregular, and the llomach prone to rejeft its contents ; and, although the patient frequently appears drowfy, for the molt part he obtains very little fleep. In fome perfons thus affeCted, thecomplaint con¬ tinues many weeks, and often acquires a confumptive character before death. When it ends favourably, the convalefcents remain long in an emaciated and enfeebled (late. An abatement of the vomiting, fome defire for light food, and a tendency to quiet fleep, are the appear¬ ances which augur recovery. The treatment of this complaint rnuft differ principally from that of Ample fever in that a minor degree of bleed¬ ing will fuffice, and in the exhibition of naufearing medicines, which are of very great ufe, notwithllanding the gaftric irritability which prevails. In a word, the treatment is that of Catarrhus, (to which the reader is therefore referred for more explicit details,) conjoined with the more aCtive and general treatment of fever. Abdominal inflammation is frequently complicated with the fever in queltion; and it is often difficult to diftinguifh the precife fituation of this occurrence; for the funClions are fo generally difordered, that their dif- turbance affords no diagnoltic, as in cafes of common in¬ flammation. It is not, however, of the utmoll import¬ ance to afcertain the precife feat of the inflammation, as the treatment does not vary eflentially. The inflamma¬ tion of the mucous membrane of the ftomach which ac¬ companies fever is fo common in fome countries abroad, that it has induced Biouflais and others, as we have be¬ fore feen, to infer its invariable prefence in febrile dif- eafes. In the works of the above author are to be found a variety of excellently-written cafes of the complication in queftion. J. P. Franck (De Curandis Hominum Mor- bis Epitome PraeieCt.onibus Academicis dicata, Ven. 1805.) more properly confines the term gujb ic fever to thole cafes in which the fever is accompanied and exaf- peraved, though nor caufed, by phlegm, bile, inteftinal worms, or other irritating matter capable of inducing an z inflamed ftate of the ftomach. We consequently generally meet with this difeafe in dyfpeptic patients when they become the fubjedts of fever. We copy from a tranfla- tion of Frank’s work the fymptoms of the gallric fever. “It begins, like other fevers, with alternate cold, fhi- vering, and heat, accompanied with laffitude, head-ache, and pains fimilar to rheumatifm in the back, the loins, and the joints. The face becomes pale, and the eyes yel- lowifh ; but the ftomach is chiefly affeCfed with inflation, tenfion, and a fenfe of weight, joined with anorexia, loathing of food, naufea, retching, and erudtation of difagreeable flatus, and of bilious, tenacious, acid, or acrid, matter. The ftate of the mouth is the belt indi¬ cation of the ftate of the ftomach, which is obfervable in the fcetid breath, the tongue loaded with tenacious white, or yellow mucus, fometimes talielefs, and at others bitter and difagreeable. Diforders in the abdomen fucceed, fuch as borborigmus, gripes, wandering pains, fenfe of. weight and fulnefs, with either conftipation, or bilious, fetid, or frothy, dejedtions. In this ftage of the affedtion the patient may not be fo ill as to be confined to bed ; but in a fhort time, though the cold fit be neither great, nor conftant, and fometimes may be abfent; the heat, thirft, giddinefs, and head -ache, increafe, the pulfe be¬ comes more frequent and often intermittent, the fymp¬ toms of the ftomach, naufea and retching, and of the ab¬ domen, are aggravated ; the flufhing of the face is greater, with greenifh palenefs towards the fides of the nofe ; the under lip quivers, the eyes are fuffufed with tears, the refpiration becomes hurried and difficult, often accompa¬ nied with a cough, either with or without expedloration; pain fimilar to that of rheumatil'in is felt in the thorax, lcapuiae, and fauces; there is often great apparent prof- tration of ftrength, with delirium, drowfinefs, or vigilia. “ After three or more days, remiffions occur in the morning, with a gentle fweat breaking on the forehead and breaft. The tongue is fometimes more loaded with yellow mucus, and fometimes dry in the middle, and of a brown colour; the urine is made with ardent pain, is, deeper yellow, or appears like that of cattle, or with a pink or furfuraceous fediment. Towards night, fome¬ times with a flight chillinefs, or (hivering, all thefe fymp¬ toms are aggravated ; the fkin becomes dry, harfh, and burning, and is fometimes fuffufed with a yellow tinge; blood often drops from the noftrils, mixed with yellowifh ferum; and the vigilia, reftleflnels, and delirum, are ex¬ ceedingly dift refling. “ As the difeafe advances, the morning remiffion al- moft difappears: the region of the liver and ftomach is more tenfe and painful ; the anxiety, heat, thirft, and head ache, become much aggravated ; the delirium is almolt conftant; the fauces are parched; the tongue, brown, livid, approaching to black, and covered with a vifcid mucous, is almolf of a fragile hardnefs and chopped; and the fpeech is impaired and fluttering. The eyes are very red, the hearing is obtufe, and the temples throb. The circulation is quickened, while the blood- veflels are contracted ; the urine, fcanty, thicker, fetid, and voided unconl'cioufly ; and the ftools, liquid, brown, or greenifh, and extremely fetid : the abdomen is inflated and founds to the touch, and the Ikin is parched or bathed in a vifcid fweat. “ If the fever in this ftage is either negleCfed or badly treated, or the patient is otherwife in unfavourable cir¬ cumftances, it will foon terminate fatally. On the other hand, if the force of the difeafe is fubdued either fponta- neoufly or by art, then the offending matters are thrown off by the bowels and fkin, the remiffions become longer and more diftind, the tongue more moift, and the mucus which covered it either floughs oft, or, as the tip of the tongue becomes redder, comes away from the edges in foftfcales. Sometimes a very fudden change now takes place: the vifcid matter almoft of a ligneous hardnefs, which was adhering to the palate, quickly foftens, and is bedewed with a bland moifture. At this period, the fe¬ ver 218 P A T H ver fometimes pafles by almoft imperceptible gradations into a periodic intermittent 5 or the exacerbation, be¬ coming in its returns more tardy and mild, terminates in an equable and moift tranfpiration ; the ftools become copious, pultaceous, and natural; and the urine depo- fites a copious reddifh- white precipitate. “ In the more mild and (low forms of the fever, the patient, on riling from deep, feels little refrefhed, is lift- Jefs and morofe, and his mouth and fauces are loaded with phlegm ; he has fetid eruftations, and copious mu¬ cous expectoration, with naufea 5 has little relifli for food, but does not altogether loathe it, though after eat¬ ing he complains of weight, fulnefs, drowfinefs, flatus, and obftruftion of the bowels. He has a flow, weak, and fometimes a full and rather-hard, pulfe, with little third. Cold (hivering is fucceeded with wandering flufhes, and dry fqualid (kin, or (light fweating; leaden heavinefs of head, and murmuring and ringing in the ears, caufing a degree of (lupidity. The vifcidity, in fuch cafes, of the mucus in the ftomach and inteftines is often fo great as to obltruft the orifice of the biliary dutt, and give rife to jaundice. The abdomen fwells, and feels painful to the touch in confequence of flatus, and of the inertia of the bowels. Singultus and difficult deglutition fucceed to great anxiety and oppreflion of the ftomach; but in a few days numerous aphthae are obferved to fpread from the fauces over the whole cavity of the mouth, which foon (lough off, and are replaced with a frefh crop. Some patients are alfo diftrefled with difficulty of breathing and cough, which is firft dry, and afterwards acco'mpa- nied with abundant and vifcid expe&oration. In this (late of things we can fcarcely call the difeafe fever, un- lefs there is greater proftration of ftrength, pains in the joints, increafing towards night, burning of the (kin, or eruptions frequently breaking out immaturely ; and more particularly if there are diftinft evening exacerba¬ tions, fucceeded by lefs diftinft remiflions, vertigo, vigi- lia, flupor, delirium, frequent fyncope, with recurrent diarrhoea, rapidly undermining the powers of the fyftem. In other cafes, great quantities of worms, fometimes liv¬ ing and fometimes dead, or nearly putrid, are ejefted both from the mouth and anus, accompanied with pecu¬ liar fcetor of the breath, and the ufual fymptoms of ver- minofe irritation ; fuch as wandering pains, lancinating pains of the joints, itching of the nofe, tremor, fainting, naufea , tenefinus, and copious dejections of putrid mucus. “When the attack of the fever is more fudden, we generally, though not always, obferve the cold (hivering to extend beyond an hour, and to recur by turns, being followed by heat, which is for the molt part parching, andincreafed towards night, often accompanied with fu¬ rious delirium. In fome cafes a flight remiflion occurs in the morning ; in others none. The pulfe is weak and indiftinCt, collapfing after it has at firft been full and fomewhat hard. There is much naufea and birternefs of the mouth, and fo great tumefaftion and oppreflion of the ftomach, that the very touch or weight of the bed¬ clothes is painful. Towards evening there is again an exacerbation, correfponding fometimes to femi- tertian intermittent; and the yellownefs of the eyes, fiuftiing, head-ache, vigilia, anxiety, fcetor of the breath, and delirium, are increafed ; and the third:, and longing for acids, is fometimes intenfe, but occafionally is flight. The urine, at the accefs of the paroxyfm, is brown, thick, turbid, and foetid ; during the remiflion, it is watery and crude. The ftools are exceedingly offenfive. Abun¬ dant but vifcid perforation gives no relief. The tongue is tremulous, and, with the teeth, is loaded with a brown vifcid matter; or it is fcabrous, almoft black, very dry, and can fcarcely be extended beyond the teeth. The flupor and vigilia increafe ; blood ru(hes copioufly from the noftrils, or is paffed with the urine and faeces ; fluid, grumous, and preceded by pain extending to the pubis. Now large quantities of aeruginous and vifcid bile are ®je£ted from the ftomach, agreeing in this almoft with O LOG It. the yellow fever of America and Siam. The ftools be¬ come more liquid, green, brown, frothy, and very offenfive; and there is feldom power remaining either to void or to retain the natural difcharges. The patient, notwithftanding, fays he is very well, and attempts to go to his friends, whom he imagines are abfent. He picks the bed-clothes, or mutters to himfelf 5 and fometimes burfts out into fits of furious delirium. This is fucceed¬ ed by fubfultus tendinum, comatofe flupor, violent pul- fation of the carotids, great difficulty of refpiration, col¬ liquative diarrhoea, cadaverous breath, hiccup, cold ex¬ tremities; cold, prof ufe, and vifcid, fweat ; very rapid, and fcarcely perceptible, intermittent pulfe; lethargic deep, convulfion, and death.” In our climate, though occafionally the gaftric fever arrives at the fame violence as above, upon the whole gaftric irritation is more (low in its prog refs. It gene¬ rally happens that the ftomach and inteftines fuffer toge¬ ther, and that the inflammation implicates the whole ltrufture of thofe parts, while in the accounts juft ren¬ dered we often perceive a phlogofts of the mucous mem¬ brane only. In this cafe the complaint is generally at¬ tended with deep continued pain, and forenefs of the integuments, increafed on preflu re ; retching, vomiting, or anorexia, defire for cold acidulous drinks; (hort quick refpiration, fulnefs as well as flatulence of the bowels, great proftration of ftrength, reftleffnefs, and anxiety. The patient almoft invariably lies upon his back, fre¬ quently tolling his arms about, moving his feet, or changing the pofition of his head. If de fired to turn upon his fide, it gives him confiderable uneafinefs in the abdomen; and, if fuddenly raifed into the upright pof- ture, he generally begins to erufl, retch, or vomit. The pulfe is fmall and (harp, and in fome cafes very quick, but in others below an hundred in a minute ; the tongue foul in the centre ; the mouth clammy ; the tafte vitiated; the bowels are, for the molt part, bound; the lips parched and pale, or fomewhat livid ; and the coun¬ tenance exprefles much did refs. The pain of the belly is augmented by yawning, by coughing, or by drawing the breath deeply down, and fometimes even by the blandelt liquids, which are ufually rejected, unlefs taken in fmall quantities at once. If the pain be acute, the (kin is often of a pungent heat about the bread and abdomen ; While the forehead and face, expofed to the atmofphere, are fometimes damp and even cold. During the advancement of the abdominal affe&ion, the pulfe grows fmaller and quicker, the vomiting more urgent, the belly tumid; the third, fenfe of internal heat, and reftleffnefs, being all aggravated. Upon the approach of fuppuration, of effufion, or of gangrene, there are rigors or flight chilly fits, with much abate¬ ment of pain ; but cold copious and clammy perfpira- tions come on, attended with (hort agitated breathing, with an hurried undulating pulfe, frequent dark lax ftools, and inceffant vomiting. Soon after this, the pa¬ tient dies. For the mod part, however, inflammation of the ftomach or bowels terminates fatally before it has advanced into aftuai gangrene ; the patient finally finking under the accumulated force of exhauftion and of irrita¬ tion. It has been mentioned, that in mod fevere cafes of gaftric fever a great derangement of the functions of the liver is found. Sometimes, however, the latter circum- ftance exifts alone. But we are not always to infer that morbid adfion of the liver exifts becaufe we meet with copious vomitings of bile ; for the act of vomiting it- felf will induce copious difcharge of bile from the health- ieft individual. We again quote, chiefly from Arm- ftrong, the hiftory of the fymptoms of this complication. “ If the liver be attacked with inflammation, giddi- nefs, load about the bread, ficknefs, and vomiting, are often among the primary fymptoms; and the patient, complaining of pain and forenefs, with weight about the right hypochondrium, can neither bear preffure in that place,. 214 PATHOLOGY. place, nor lie upon the left fide, without an increafe of pain. When the convex furface of the liver is the feat of the inflammation, it is fometimes not very eafy todif- tinguifh the hepatic aflfeftion from pleuritis: but in the former uneafinefs is excited by prefling the hand under and above the falfe ribs, and there is generally fome pain at the top of the flioulder; circumftances not commonly obfervable in inflammation of the pleura : and further, the cough and dyfpnoea are not fo diftrefling as in the latter, while the abdominal fecretions, efpecially thofe of the liver, are much more vitiated.” The cough is for the moll part dry, but fometimes hu¬ mid, and frequently excites a pungent pain in the part affefted, with a tendency to naufea, retching, or vomit¬ ing. The fpirits and ftrength, particularly the former, are much deprefled ; the mind is apprehenlive, confufed, or flightly delirious, the pulfe quick and hard ; or low, intermitting, or opprefled ; the breathing anxious and variable; the tongue covered with a dirty white, or yel- lowilh, more frequently with a brown fur; the urine fcanty and deep-coloured ; the bowels are generally irre¬ gular; and the fasces dark, flimy, varied, and mixed with morbid bile. The heat of the Ikin, though fome¬ times only a little, is at other times much, above the ltandard of health ; it is fometimes jaundiced. Dr. Arm- ftrong Hates, however, that this fymptom often occurs without inflammation of the liver. It is to be remarked, that there is often much obfcurity in tracing the prefence of gaftric fever or inflammation in any part of the abdominal fever, when it aflumes a flow and mild form. But the exiftence of this Hate in any part of the belly may be inferred in continued fever, when, after the fupervention of the ftage of excitement, the ftomach remains uncommonly irritable; when there are conftant feelings, however trifling, of weight or un¬ eafinefs about the fcrobiculus cordis, when there is quickened or anxious refpiration ; a change always ob- fervable in abdominal, feldom in cerebral, irritations. We fliould alfo note the fmall and rapid pulfe, the in- diftinfl chills and heats, the dry or foul tongue, with thirlt, reftleflnefs, frequent erudlations, fenfe of internal heat, forenefs, or pain, in fome particular part ; and an unufual quantity of dark, thick, fluid matter in the ftoois on the operation of a purgative. The progrefs, indeed, of fuch affedlions mull be traced by the above fymptoms ; /or pain is not very confpicuous. But the bell method of finding out obfcure abdominal inflamma¬ tion is to prefs forcibly on the bowels at a time when the patient’s mind is occupied with fome other objeft. It is proper tofelefl this opportunity; for oftentimes patients complain of pain in reply to the queftion “ Does preflure hurt you ?” becaufe they expect that fuch will be the cafe. The mod important feature in the treatment of the gaftric complication of fever is its inertnefs. This is a fail not fufflciently dwelt upon in this country; and, though the too great dependance which our Gallic neighbours place upon medicated broths, eau fucre, &c. may be worthy of cenfure when fuch remedies are ap¬ plied to inflammatory complaints in general, yet, when the inflammation is confined to the mucous lining of the alimentary canal, the mere omiflion of irritating medi¬ cines, whether cathartics or Simulants, will do much for the cure of the difeafe. The nature of our treatment in abdominal inflammation will depend therefore upon whether the inflammation be confined to the above tube, or whether it more generally implicates the furrounding vifcera. In the firlt cafe, free general bleeding feems by no means called for, though leeching the abdomen is highly neceflary. As in this cafe a large quantity of ir¬ ritating fecretions have been colledted, to the great ag¬ gravation of the gaftric difturbance, it fliould be our firft care to evacuate them from the fyftem. In doing this, we fliould life fuch remedies as are mod likely to bring about the defired effefl without, by their own properties, irritating the inflamed membrane. In the firft place, am¬ ple dilution with acidulated drinks is to be had recourfe to ; an emetic is the next thing to be prefcribed, and its ef- fedl is often miraculous ; but, after the firft time of giving it, its repetition feems by no means admiflible. The evacuation of the bowels is to be effected by a dofe of caftor oil, if the ftomach does not rejeft it, and by ene¬ mas : by the latter remedies, compofed of oleaginous (or in cafes of fevere pain of anodyne) decodtions, the alvine difcharge is to be regularly kept up. The medi¬ cines are to be fuch as at once diminifti the temperature of the ftomach ; as, the common faline draughts, nitre largely diluted, &c. occafionally fmall dofes of antimony may be ufed. Nofolid food or animal broths Ihould be allowed ; but cooling drinks may be taken in large quan¬ tities, together with fweet mucilaginous decoctions. Now, if the collatitious vifcera feems more deeply im¬ plicated, much will depend upon the Hate of the general fever. If the latter be highly manifefted, if the tempera¬ ture be high, and the pulfe ftrong, bleeding and after¬ wards cupping over the aflrefled part mull be had recourfe to without lofs of time. If, on the other hand, a vio¬ lent and intenfe inflammation fupervenes, while the ex¬ citement of fever is not marked, (and this is no uncom¬ mon occurrence,) we fliould endeavour to excite thofe parts of the body which difplay a diminution in the quantity of their circulating fluids. To this end a hot bath mud be premifed before we bleed ; and, in perform¬ ing the latter operation, we fliould carefully watch the riling of the pulfe ; an occurrence fo important, that we may occafionally endeavour to promote it by cordials and ftimuli. After this, finapifms to the feet, and other counter-irritants, will be found ufeful agents. It will be neceflary alfo to excite the fecernent fyftem generally by large dofes of calomel and opium. When inflammation of the liver is clearly manifefted, or when the mucous membrane of the bowels is threat¬ ened with ulceration, in additipn to the ufual revulfive meafures we fliould exhibit calomel in five-grain dofes, combined with half a grain of opium, every fix hours, till ptyalifm is induced. We may remark, that no gene¬ ral rules can be laid down as to the ufe of blifters : they are for the inoft part of the utmoft efficacy in relieving the local complications attendant on continued fevers ; but they require to be applied with much care, as to the ftate of the fkin generally; for, when inflammation of the mucous membrane of the alimentary canal is at¬ tended with much heat and rednefs of the fkin, it is ge¬ nerally found that blifters increafe rather than alleviate the complaint: they alfo aft in a detrimental man¬ ner in cafes where exceffive nervous irritability is prefent. Befides the complications before mentioned, we fome¬ times find rheumatifm or angina united with fever. De¬ pletion may be pufhed to the utmoft extent in the for¬ mer; in the latter, quite the reverfe. In taking leave of the treatment of continued fever, we have to fay a few words on the management of conva- lefcents. It is too much the pra&ice even in this coun¬ try, and it is carried to a much greater extent abroad, to give bark and other ftrengthening medicines, as they are improperly called, to thofe who have efcaped from fe¬ vere attacks of fever. We have no liefitation in ftrongly reprobating this practice. We fliould anxioufly incul¬ cate, that ftrength is only to be attained through the me¬ dium of healthy digeftive organs ; and that, when thefe are ftrong, a very fmall ^quantity of fuftenance will pro¬ duce a high degree of nutrition, hjpw, as fudden ple¬ thora is proverbially “ a bad fign” when it fupervenes to fevers, we fliould be cautious of producing it by exciting in an unnatural manner the energies of the digeftive or¬ gans, and we fliould rather fuffer them to recover their tone (which they will generally do) in a gradual manner, and by means of their own powers. We now proceed to the confideration of Yellow Fe¬ ver; a difeafe at the prefent moment committing dread¬ ful PATHOLOGY. Ful ravages on mankind, and concerning the origin of which the medical world is much divided. The conflift- ing opinions of medical men on this fubjeft are indeed well known to the public ; the grand quelfion to decide being whether yellow fever is contagious or not. It is by no means eafy however to trace the operation of the in- fcrutable agents which give rife to this difeafe : and hence, while one phyfician attributes its diffufion to exhalations from the body of the human fpecies, another finds per¬ haps in the fame cafe evidence of its origin from miaf- mata. In a late number of the Medical Repofitory we find the names of numerous and refpeflable authors mar- fhalled in regular array againft each other as taking oppo- fite fides in this important queftion, We copy the chief of thefe, that thofe who want to examine cloftly the evi¬ dence on each fide may have recourfe to it. Among thofe who confider yellow fever to be an im¬ ported and contagious difeafe, are ranked Arejula, Batt, Berthe, Dalmas, fir J. Fellowes, Moreau de Jonnes, B. Progetto, Salgado, &c. who found their opinions on the yellow fever of Spain; and more recently Parifet holds the fame opinion. Alfo Bally, fir Gilbert Blane, Cai- zerques, Chifholm, W. Currie, Des Portes, D’Oyarvide, Lind, Ried, &c. who derive their fatlfts from the Weft Indies and America. Among thofe who deny that yellow fever is conta¬ gious, and afl'ert its origin to be entirely local, or depen¬ dent upon fome myfterious and inappreciable change in the atmofphere, are ranked Amiel, Burnett, Caftan, Doughty, Keutfch, Lacofte, Langerman, O’Hallaran, See. who draw their obfervations chiefly from the fever of Spain ; and Bancroft, Barker, Browne, Comftock, Clarke, Coventry, Davidge, Denmark, Deveze, Dickfon, Fer- gufon, Gilbert, Hillary, J. Hunter, R. Jackfon, Jeft'er- fon, M'Artlnir, M‘Lean, E. Millar, Moore, Mofeiy. Muf- grave, Mnttlebury, Ramfay, A. Robertfon, B. Rndi, Sa- varefi, Selden, Sheppard* Trotter, Valentin, Vanel, Veitch, Whitehead, &c. in the Weft Indies and America ; and in Africa, Drs. Copland and Winterbottom. Among thofe who hold a middle courfe, allowing the local origin of the fever, but afferting that it may be¬ come contagious, we find Eytnann, Hofack, Humbolt, J. Johnfon, Le Blond, Nicol, Palloni, Pugnet, Romans, ‘ Sec . To thefe we mull add the Angular opinions of Baron Larrey. This author divides virus into two kinds ; the one fluid, as in fiphilis, fmall-pox, and vaccina; the other gafeous, or miafmatici of this laft fort is (he fays) the virus of the yellow fever. Each virus has a particu¬ lar influence on certain parts. That of the yellow fever adds particularly on the nervous fyftem of animal and or¬ ganic life. It is connedded with the lymphatic fyftem ; and, according to him, it is the moft fubtle and fuga¬ cious of all. It lafts but a moment at the higheft point of difeafe; and then lofes the power of tranfmitting it- l’elf. It is principally feated in the exanthema when this exifts, and in the cutaneous tranfpiration. It is in this manner that M. Larrey endeavours to reconcile the con- tradi&ory opinion of phyfleians on this fubjeft. He is, however, an advocate for meafures of precaution ; for if, lays he, one patient only out of a hundred lie capable of tranfmitting the difeafe, prudence requires that the whole Ihould be fequeftered, as it is impoflible to afeertain the individual by whom the difeafemay be perpetuated. For our own parts, we can only give the ccnclulions we have arrived at from an attentive perufal of moft of the above w'orks. It would far exceed our limits to de¬ tail, even in the moft comprefted form, the arguments of thefe numerous and confliffing authorities. But, taking up thofe opinions which feem to have been moft carefully induced from fadis, and which in fome manner explain ffte diftonant evidences of various authors, the follow¬ ing circumftances appear to us tolerably well eftablifhed. Firftthat the yellow fever, the bilious remittent, the Bengal fever, the liulam fever, See. are all one and the VOL. XIX. No. 1258. 215 fame difeafe modified by varieties in climate, conftitution, and predifpofing caufes ; that is to fay, that they are fo far the fame difeafe, that their fundamental therapeuti¬ cal indications are fimilar, and that they are apt, when external circumftances ferve, to run into each other. Secondly, that this fever is for the moft part caufed by certain miafmata from marfhy foils, which miafmata are fuppofed to be the prodmft of putrefying vegetable fub- ftances, it being urged that animal putrefaction is not found to produce yellow fever. This, however, is by no means clearly afeertained. It is afferted that the mial- mata in queftion are generated for the moft part in fixa¬ tions where the water has receded or been partially dried up, and where confequently the muddy bottom is ex¬ posed to the fun’s rays. It is afterted alfo, that an high temperature is an indifpenfible condition to the produc¬ tion of thefe miafmata, or at leaftto their morbid aftion on the human body ; whether fuch heat be in aftual ex- iftence,or whether it has immediately preceded a fudden acceftion of cool weather. Though thefe miafmata from marfliy foils are undoubt¬ edly in many inftances the foie caufe of the yellow fever, yet fomething mull be often attributed to the influence of defeending dews from the atmofphere. Indeed Dr. James Johnfon mentions having himfelf experienced the ienfible eft’edl of this dew on-board of a (hip; and it feems very probable that jt was only by the preventive treatment he employed, that he warded off an attack ot this fever. This author likewife informs us, that a fever which broke out in the Leopard’s crew followed upon a defeent of dew which took place every night, and was perfectly Jalt and litter to the tojle. The above-men¬ tioned fad, according to Dr. J. Johnfon, leads to a “ praftical inference of confiderable utility; viz. that, when neceftity compels us to penetrate through thofe in- falubrious woods, jungles, or marlhes, we fhould feleCt that point of time at which ive are lead likely to meet thofe miafrns, whether in their afeending or defeending ftate. This period feems to extend from three to fix o’clock in the afternoon ; that is, after the greateft heat of the earth and air, and, confequently, the greateft eva¬ poration ; and before the condenfation and return of fuch exhalations as rofe during the day, and which combine with thofe ftill iffuing from the heated foil for fome time after fun-fet. Independently of this cir- cumftance, the body feems to be pofleffed of greater energy at this period of the day than at any other, it being that time when the principal meal is nearly di- gefted, and confequently the animal vigour at its higheft pitch. The deprefling paflions, intemperate or bad liv¬ ing, and the other predifpofing caufes of the fever of this country, aCt with equal or greater force in aflifting the baneful operation of the mialms of yellow fever. Thirdly, it is inferred as a probability, (for we have no evidence of our own to offer,) that yellow fever ari- fing from miafmata may in fome conftitutions generate the volatile material which other fevers do, and produce contagion. Independently of the evidence derived from the authors before mentioned, the principles we have laid down when treating of contagion lead to the fame conciufion. Indeed, when we confider the nature of contagion itfelf, we cannot refufe ouraffent to the propo- fition in queftion. We fee that a fever, clearly traced in the firft inftance to local injury, will, under the con¬ comitant circumftances of foul wards in an hofpital, deficient ventilation, & c. engender contagious fever through large bodies of men ; fo that we infer that any fever, however induced, may be contagious, feeing that its local origin does not hinder the contagions effluvia from being produced. Moreover, let us confider the manner in which contagion is produced. Itmuftbearo- lalilefecretion ; and this can only arife from the mucous membrane. Now, when we fee the great variety of ap¬ pearances- which the vifible produdfts of this membrane exhibit when inflamed, can we doubt that in almoft ail 3 K violent 21G PATHOLOGY. violent inflammations contagious effluvia may be fecreted. In common ftates of the atmofphere, this is probably mixed, diffufed, and decompofed ; but in peculiar con¬ ditions of the air a fufpenfion may take place, and thus contagious fever may be rendered general. Now that the morbid fecretions of the mucous membrane are con¬ tagious effluvia, and that thef'e are modified by nervous impreflions in the fame way as all fecretions are, feems rendered (till more probable by the circumftances, that in thofe fevers which are molt contagious, viz. the exanthe¬ mata, a phlogofed ftate of the mucous membrane is uni¬ formly prefent, and that an emetic exhibited early in thofe maladies often prevents the attack; a faft which we can only explain on the fuppofition that this remedy actually removes a depofited fecretion, or, in other words, contagious effluvia from the furface of the ftomach. In faff, there feems good evidence in fupport of the opinion, that all inflammation of, or difordered fecretion in, the mucous membrane may elicit contagious effluvium. Thus dyfentery, cholera, eryfipelas, the influenza, (a fpecies of catarrh,) have all been fometimes contagious, though it is well known that all thefe difeafes occur without fucli an effect being produced. Nor, can we, on the fame account, difmifs with the abfoiute denial which molt authors have thought proper to do, the well- fupported aflertion, that croup and phthifis are occafion- ally catching. To return to the yellow fever; it is to be remarked, that a confideration of the medical topography of the countries where this fever has appeared mult difclofe grand and important circumftances relative to the ma¬ nagement of our fleets and armies. As this fubjeft, however, embraces a wide field in a branch of medical fcience hitherto not cultivated fyftematicaliy, we regret that our limits will not permit us to difcufs it fully ; but we can, with the utmoft confidence, refer our read¬ ers to a work by Dr. James Johnfon on Tropical Cli¬ mates; which contains all that is at prefent known on the fubjeft. As to the nature of yellow fever, its immediate caufes operate of courfe, as in other fevers, through the medium of the mucous membranes; and the irritation which is communicated to the brain and fpinal marrow forms the grand connefting and eflential link to the de¬ velopment of the general febrile phenomena. The ac¬ tion of the predifpoling caufes, as climate, fatigue, &c. is however to render the mucous membranes particularly liable to inflammation ; while the fame influence, by af- fefting the circulation of the furface, as was (liown when treating of Cholera, throws unnatural quantities of blood into the portal fyftem, and produces congejlion there, this being the only part of the venous fyftem where fucli a ftagnation can take place. The eft’eft of this is particularly felt in the liver, the ftoinach, and indeed the whole abdominal vifcera. The charafteriftic fymptom of this fever, viz. the yel¬ low colour of the fkin, is varioufly accounted for by dif¬ ferent authors. Dr. Bancroft fuppofes it is induced by the preflure to which the aft of vomiting fubjefts the li¬ ver and gall-bladder. But to this it is replied, that there is no proportion between the intenfity of colour and the feverity of the vomiting ; and moreover, that it often occurs before the vomiting takes place. Brouf- fais is of opinion, that the yellow colour depends on violent irritation of the duodenum propagated to the fe- cretory organ of the bile. The moft plaufible opinion, however, though it has been much ridiculed, feems to be, that the fufpenfion of the aftion of the liver prevents the elimination from the blood of the bilious elements, and that thefe, exifting in the blood from the want of fecre¬ tion, and not from abforption, produce the phenomena in queftion. We have fome reafon to believe, that a morbid ftate of blood might caufe the fame appearance without the liver being materially implicated. This indeed, as far as regards certain yellow dingy patches which occafionally appear on the (kin in this fever, is al¬ lowed by Dr. Bancroft. The black vomit, a moft formidable fymptom in yellow fever, was for a long time attributed to a fuperabundant and altered fecretion of bile ; but certainly without foun¬ dation, as is evident from the faft, that in a great number of difleftions the liver has been found in a healthy ftate ; and, where it has differed from its natural appearance, it has frequently been of a paler colour; the gall-bladder has alfo at the fame time been found in a healthy ftate, containing its ufual quantity of bile, not at all altered in its appearance or properties. Moreover, at a time when the ftomach has been diftended with black vomit, the paf- fage from the duodenum into the ftomach has been com¬ pletely obftrufted by the pylorus valve, fo that no portion of the matter could have been derived from the hepatic fyf¬ tem, in every part of which fyftem the bile was quite natu¬ ral in colour, tafte, and confiftence. The matter of black vomit, compared with bile, differs materially from it in all its phyfical qualities. It differs from it in colour; for, however dark the bile may appear in its moft concen¬ trated ftate, it always difplays a yellowifh or greenifh- yellow tinge, when fpread on a white furface, or when diluted ; and this is never obferved with the matter of black vomit. Indeed Dr. Bancroft has found that an addition of bile to the latter, altered its nature fo much as to give it an appearance different from what it had be¬ fore ; nor could the black vomit be imitated by any mix¬ ture of various proportions of dark-coloured bile with the fluids found in the ftomach. It differs moft deci¬ dedly in tafte; the black vomit being always infipid, when freed from other foreign matters; whereas the bile can never, by any means, be deprived of intenfe bitter- nefs. A natural conclufion therefore is, that the black vo¬ mit proceeds from the ftomach itfelf, and is a confequence of inflammation of that vifcus; whether this be a par¬ ticular morbid fecretion by the inflamed veffels or glands of the ftomach ; or, as Dr. Bancroft thinks, “ merely blood which has been effufed from fome of the fmall ar¬ teries, ruptured in confequence of the feparation of cer¬ tain portions of the villous coat-, and which has coagu¬ lated within the general cavity of the ftomach, or on the furface over which it was effufed ; and, having been af¬ terwards detached and triturated by the violent and fre¬ quent contraftions of that organ in the efforts to vomit, has had its appearance as a coagulum of blood altered, and its colour darkened by the gaftric juice, or by fome chemical decompofition, either fpontaneous, or produced by the aftion of the air, or other matters contained in the ftomach.” It remains to give a defcription of the fymptoms of this fever, which we believe will be found to agree accu¬ rately with the above fhort pathological lketch. The defcriptions, not being drawn from our own obfervation, are felefted from the moft accredited authors, whofe names we fhall fubjoin. The chief diftinftions between the different forms this fever exhibits are drawn from its violence, or, what amounts to nearly the fame, its con¬ tinued, its remittent, or its intermittent, form. The firft defcription is that of Dr. Bancroft, derived from the contemplation of this fever in the weftern he- mifphere. “ The progrefs and violence of the yellow fever differ greatly, according to the force of its caufe, the vigour and excitability of the patient, and the feafon of the year. When it prevails epidemically in hot cli¬ mates, and attacks young and robuft men, lately arrived from temperate regions, the diforder commonly appears in its moft aggravated form. In this, the patient firft complains of laflitude, reftleffnefs, flight fenfations of cold and naufea, which fymptoms are foon fucceeded by ftrong arterial aftion, intenfe heat, flufhing of the face, rednefs of the eyes, great pain and throbbing in the head and in the eye-balls, uneafinefs and pain in the ftomach, opprefflon of the praecordia, a white fur on the tongue. PATH and a dry parched (kin, with a quick, full, tenfe, and generally ftrong, pulfe, though it is fometimes oppreffed and irregular. Thefe fymptoms are fpeedily accompanied by frequent efforts to vomit, efpecially after fwallowing food or drink, with difcharges, firft of fuch matters as the ftomach happens to contain, and afterwards of con- fiderable quantities of bile, appearing firft yellow and then green, fometimes tinged with blood, but in the progrefs of the diforder with matters of darker colours : an increafe of pain, heat, and forenefs of the prsecordia, alfo occurs, with conftant wakefulnefs, and frequently with delirium more or lefs violent. This paroxyfm, or exacerbation, which has been called the inflammatory or the febrile itage, generally lafts thirty-fix hours, but is fometimes protratted for feventy-two hours, and even longer, probably in confequence of either general or local inflammation, (particularly in the brain or llomach,) or of irregularity in the circulation, which are known to prolong the paroxyfms in fevers of type. “A remiflion then occurs, in which many of the fymp¬ toms fubfide, fo as often to induce a belief that the fever is at an end, and recovery about to take place. Fre¬ quently, however the foundations of irreparable injury to the brain or ftomach have already been laid in the former paroxyfm ; and in fuch cafes the remiflion is fliort and imperfedt. During thefe remiflions, the pulfe often returns apparently to the condition of health ; the flcin feels cool and nioift, and the intelledt, if previoufly dis¬ turbed, Fometimes becomes clear; fometimes, however, the patient remains in a quiet and ftupid ftate, a fymptom generally denoting great danger. Another fign of dan¬ ger, as denoting a very morbid condition of the ftomach, is the renewal of the efforts to vomit, when preffure is made on that organ, or food is fwallowed. After a certain interval, this remitting ftage is fucceeded by another, which may be called a lecond paroxyfm, and which, pro¬ bably, would appear as a renewed exacerbation, if the violent effefts of the firft had not almeft exhaufted the patient’s excitability, and in conjunction with the ex¬ treme depreflion of ftrength which ufually attends in¬ flammation of the brain or ftomach, rendered him nearly unfufceptible of thofe morbid addons which are neceffary for that purpofe. In this latter ftage, then, inftead of great febrile heat,' and ftrong arterial aCtion, the warmth of the body, and the frequency and ftrength of the pulfe, are often lefs than when the patient was in health; but frequently the pain and heat in the ftomach become ex¬ cruciating, with inceffant (trainings to vomit, which, in moft of the fatal cafes, are followed by hiccough, and re¬ peated difcharges of matters refembling turbid coffee more or lefs diluted, or the grounds of coffee, and alfo by evacuations of fimilar dark matters from the bowels. Here it is to be obferved, that, when thefe fymptoms oc¬ cur, (indicating a violent affeCtion of the ftomach and bowds,) the patient is, in general, fufficiently in poffeflion of his intellects to know thofe about him, and to give diftinCt anfwers to queftions made to him, although his exceflive weaknefs often renders him incapable of mental exertion, and his inability even to raife his head may induce the appearance of coma. In thofe cafes, however, in which the brain has fuffered greater injury than the ftomach, the retching and black vomit, juft defcribed, do not fo commonly occur ; but, inftead of them, low muttering, or coma, with convulsions of the mufcles of the face, and other parts of the body, fupervene. About this time, alfo the tongue and teeth are covered with a dark-brown fur ; yellownefs of the (kin and petechias make their appearance ; the urine has a putrid ftnell and dark colour; the feces likewife become moft offenfively putrid; haemorrhages fometimes take place from the nof- trils, gums, and various other internal furfaces. There is in fome patients, a fuppreflion of urine ; in others, an involuntary difcharge of it, and of the feces: the pulfe becomes feeble and intermits ; the breathing is laborious; O L O G Y. 217 portions of the (kin affume a livid colour; the extremi¬ ties grow cold ; and life is gradually extinguifhed.” On the above defcription Dr. J. Johnfon remarks, that the propriety of characlerifing the fubfidence of great heat and vafcular adion at the clofe of the firft ftage as a remiflion, is very queftionable. It is, in fact, (fays he,) the tranfition from inordinate adion to exhauftion; to that almoft hopelefs ftate which (the foundation of almoft irreparable mifchief having been already laid in the moft: important vifcera) is fpeedily to terminate in diforgani- zation and death, and has nothing in it of the falutary tendency of a remiflion. As Dr. Gillefpie obferves, “it is proper to caution young praditioners againfta miftake very common with regard to the yellow, or ardent fever; that is, of taking the fatal ftage which follows the ceffa- tion of ardent heat and great excitement, and which ac¬ companies a fphacelus of the vifcera, for a falutary crifis of the difeafe.” Difeafes of Seamen. — “ Cette diminution des fymptomes en impofe quelquefois au malade, et memo aux medecins inexperimentes.” Did. des Sciences Me- dicales, tome xv. p. 336. This declenfion of fever at the clofe of the firft ftage excited early attention, and is often fo marked as to have been frequently miftaken for a proof of returning health. It is noticed by Dr. Hume, who had the charge of the naval liofpital at Jamaica between the year 1739 and 1749, and was afterwards a commiflioner of the Sick and Hurt Board, in the following terms : “The pulfe is at firft full, quick, and ftrong ; but in forty-eight hours after feizure, or thereabouts, it fometimes becomes calm and regular, fcarcely to be diftinguiftied from the pulie of a perfon in health.” See Dr. Hume’s Account of the Yellow Fever, publiflied by Dr. Donald Munro. Now, that we may more firmly eftablifh the accuracy of the above defcription, as well as fliow the corrednels of Dr. Johnfon’s remark, that the partial diminution of pain and uneafinefs is not properly a remiflion, we fub- join the following account of the fame fever as it oc¬ curs in another part of the weft. It is detailed by Dr. M'Arthur. According to that author, this fever is ufually ufttered in by the fenfations which precede other fevers ; fuch as lailitude, ftiffnefs, and pain of the back, loins, and extremities; generally accompanied by fome degree of coldnefs. Tilde are foon fucceeded by a fevere pain of the head ; a fenfe of fullnefs of the eye-balls ; into¬ lerance of light ; ikin dry, and imparting a burning heat to the hand; pulfe full and quick ; tongue covered with, a whitifli mucus, but often not materially altered from the ftate of health ; bowels bound. “ I may here remark, that the adual degree of heat, as indicated by the ther¬ mometer, is not proportionate to the intenfity commu¬ nicated to the touch. It generally varied between 990 and ioa°, very feldom exceeding 1030. yet the Ikin im¬ parted a burning cauftic fenfation to the hand at thefe times. If the patient has been attacked in the night, he awakes with oppreflive heat, head-ache, and the other fymptoms of fever, the fenfation of cold having pafled unnoticed. At other times, after fatiguing exercife in the fun, and fometimes after a hearty meal, the violent head-ache, and other fymptoms of the fever, are ulhered in by an inftant lofs of mufcular power, and immediate depreflion of nervous energy. The patient, as if he were ftunned by a blow, falls down, his eyes fwimming in tears. In thofe cafes, delirium is an early fymptom. In a few hours, the pain of the loins increales, and, in aggravated cafes, llretches forward towards the umbili¬ cus ; the countenance is flufhed ; the white of the eye as if finely injeded by blood veffels, the albuginea appear¬ ing through the interftices of the network of veffels, of a peculiar blue (hining cartilaginous whitenefs. “ During the firft twelve hours, the patient is not par¬ ticularly reftlefs, enjoys fome fleep, and, when covered by the bed-clothes, has partial perfpirations on his face, neck, and breaft. About the end of this period, there is tVgreat 4 218 V A T H O a great exacerbation of the fever ; he becomes reftlefs ; the heat and drynefs of the (kin increafe ; there is much pain of the eyes and frontal finufes ; the pain of the thighs and legs is augmented ; third is increased, with a fenfa- tion of preffure about the region of the domach. Naufea and vomiting occur towards the end of the fird twenty- four hours. If the fever has not been arretted within thirty-fix hours from its commencement, the patient is in imminent danger, and all the fymptoms are aggrava¬ ted ; the pulfe is ftrong and full, and pulfation of the carotids appears diftindl on each fide of the neck. The (kin continues hot and dry ; the third is increafed ; there is much anxiety, the patient continually (hifting his pof- ture ; the urine becomes high coloured ; all his uneafinefs is referred to his head and ioins. A fenfation of pain is felt about the umbilicus, when prelfed upon ; the white o( the eye now appears of a dirty concentrated yellow colour, and apparently thickened, fo as to form a ring round the margin of the cornea. The blood-velfels of the eye appear more enlarged and tortuous ; knees drawn up¬ wards to the abdomen ; frequent vomiting, with much ftraining;mucus,and hiscommon drink only, beingejefled. “Delirium comes on about the end of the fecond day. There is now a drynefs, or (light fenfation of forenefs, of the throat when fwallowing ; and about this time an urgent fenfation of hunger frequently comes on, and a remarkable want of power in the lower extremities, re- fembling partial paralyfis of the limbs. About this time, alfo, the pain of the loins is fo fevere, that the patient exptefl'es himfelf as if his back was broken. The third day, or dage, begins by apparent amelioration of all the bad fymptoms, the vomiting and third excepted. The matter ejefted has fmall membranaceous-looking flocculi floating in it, refembling the crufl wadted from a port- wine bottle- The third is now urgent, and there is an inceffant demand for cold water, which is almofl imme¬ diately reje&ed by the domach. The heat of the (kin is reduced; the pulfe finks to, or below, its natural flan- dard ; the patient, for an hour or two, exprefi'es himfelf to be greatly relieved ; and, at this time, a perfon unac¬ quainted with the nature of the difeafe would have hopes of his recovery. This date, however, is of fiiort dura¬ tion, and the delufion foon vaniflies. The delirium in- creafes ; the matter ejected from the domach becomes black as coffee-grounds, and is fiomewhat vifeid. Diar¬ rhoea comes on ; firfl green, then black, like the matter vomited. The patient often complains of being unable to pafs his flools, from a want of power i n the abdominal mulcles. There is an acrid burning fenfation of the do¬ mach, and forenefs of the throat, extending along the whole courfe of the oefophagus, in attempting tofwallow; eyes, as if fuffufed with blood ; (kin a dirty yellow ; parts round the neck, and places preffed upon in bed, of a livid colour. More or lefs haemorrhage takes place from the nofe, mouth, and anus; and a depofition of blood from the urine. The delirium becomes violent ; the body as if it were writhed with pain, the knees in- celfantly drawn up to the belly. The patient feizes, with convulfive grafp, his cradle, or any thing within his reach, and prefers the hard floor to his bed. The pulfe now finks; refpiration becomes laborious; the counte¬ nance collapfed ; the ludre of the eye gone. For fome hours, he lies in a date of infenfibility before death ; at other times, expires after fame convulfive exertion, or ineffectual effort to vomit. The tongue is fometimes but little altered during the courfe of the fever; and, if loaded in the early dages, it often becomes clean and of a vivid red before death. “Such is the regular fucceffion of fymptoms which characterize this fever, but of longer or (horter duration, according to the violence of the difeafe, or drength of the powers of life to refid it. In weakly habits, the vaf- cular aCtion at the beginning is lefs marked ; and, in thefe cafes, the fever is generally more protracted, and LOGY, the patient expires unaffeCted by the laborious refpira¬ tion, and convulfive motions, which attend the lad drug¬ gies of life in the more violent degrees of this endemic. Very often the patient retains his fenfes till within a few minutes of his death; and fometimes will predict, with confiderable precifion, the hour of his didolution. “ In the early dages of the word cafes of this fever, there is much anxiety in the countenance of the patient, who expreffes a defpair of recovery ; and I have never noticed a remijfwn during the whole courfe of the fever. Se¬ veral cafes of remittent fever under my care terminated in the endemic fever. “A certain number of thofe attacked by this fever, if prompt meafures to fubdue it had been employed, reco¬ vered from its fird dage. They exhibited evident figns of amendment within the firll twenty-four, or at far- thed thirty-fix, hours, from its fird attack. Alfo, a confiderable proportion recovered from the fecond dage; that is to fay, previoudy to black vomiting unequivocally appearing. But I have only known thirteen cafes, in above five years, to have recovered from the lad dage. Some of thefe were afterwards invalided, in confequence of dyfpeptic complaints, and generally-difordered dare of the domach and other abdominal vifeera. In thefa cafes, the domach gradually became retentive ; the eyes and (kin became of a more vivid yellow; they had re- frelhing deep, but continued extremely weak and languid for a longtime. The oozing of blood from the fauces and gums alfo continued for fome days ; and the depo¬ fition of blood in the urine remained longed ; this ex¬ cretion being always the lad to return to its natural healthy condition. “ Pain of the back, early dretching round to the na¬ vel ; forenefs in the throat and cefophagus ; heat and acrid fenfation in the domach; urgent third ; hunger; want of power, refembling paralyfis of the limbs ; violent delirium ; defpondency ; enlargement of the blood vef- fels, and a red-yellow colour of the white of the eye, either fingly or colledlively, indicate extreme danger ; and, when the black vomit has appeared, fcarcely a hope remains.'” The next form of yellow fever, is the inflammatory en¬ demic which attacks new comers, (efpecially when they live intemperately,) on their arrival in the Wed Indies. The reader will fee the precife fimilarity between this fever (which is allowed to arife from the united influence of plethoric conditution, intemperate habits, and changes in the temperature of the air) and yellow fever. Its fymptoms are thus deferibed by Nodes Dickinfon : “ In its feverer afpeft, and when negledted at the attack, this fever confids of two dages. In the fird, there is increafed excitement, refulting from an unufual dimulus applied in an excefiive degree to a fydem peculiarly fenlible to its impreflion : it produces a derangement in the func¬ tions of fome or many vifeera. If this goes on, the fe¬ cond dage appears, in which the drufture of thefe vifeera is altered to a degree incompatible with the living date. Thus the difeafe proceeds from high excitement to ir¬ reparable exhaudion, as we (hall perceive by attending to the hidory of its fymptoms,. In the lefs fevere ex¬ ample there is chillinefs at the onlet, foon followed by a permanent and univerfal fenfe of heat, fluflted face, in¬ flamed eyes, head-ache, increafed fufeeptibility to tbs imprefiions of light anti found, vertigo, drawfinefs, figh- ing, white tongue, arid fauces, third, wandering pains, lofs of appetite, codivenefs, high-coloured urine, dry (kin, naufea, with full and frequent pulfe; — (hould thefi* fymptoms in a fevere degree remain without control, the difeafe is foon increafed to its mod aggravated form. The patient is extremely refllefs, with a continual defire to alter his poiition, but without relief. The heat and head-ache are intenfe ; the carotids throb with unufual violence. There is fometimes a furious delirium; tin¬ nitus aurium, and even lofs of fight. There is. occa- fionaily, 219 PATHOLOGY. fionally, a dry cough with pain in the fide, and almoft invariably a fenfe of heat, oppreffion, and pain on prel- fure at the prsecordia, accompanied by eonftant fighing.- Vomiting- fometimes comes on very early in the attack. There is often great drowfinefs, but no refrelhing deep. In 1'orne cafes an acute pain is felt in the right fide ; and a yellow colour of the Ikin often fupervenes. This yel- lownefs is occafioned by the prefence of bile, which is alfo detected in the urine and ferum difcharged from the blifters. Should the paffage of bile into the intef- tines fpontaneoufiy take place, or be procured by the aftion of purgatives, this jaundiced appearance will ge¬ nerally be prevented : neverthelefs, in feme cafes it may ofiibly a rife from a redundant fecretion, even when the ilious canals are free ; and a bilious vomiting and purg¬ ing may . occur with the yellownefs of the fkin, and carry off the attack. Thefe fymptoms proceed with various degrees of violence, and they occupy an uncertain period. Within twelve, twenty-four, or thirty-fix, hours, or perhaps after a longer but indefinite time, an important change takes place. It marks the commencement of the fiecond ftage. Many of the molt urgent fymptoms de¬ cline. The pain and heat of furface fubfide. There is a fenfe of cold with dampnefs of the Ikin. This change at fir ft fo much aflumes the appearance of febrile remif- fion as to give great hope to the inexperienced pra&i- tioner; but it fpeaks a ftate of the utmoft danger. In fome cafes the patient finks, at once, after the fubfidence of excitement, apparently deftroyed by the general affec¬ tion, without any previoufly-fevere determination of blood to particular organs; and he dies at the moment of hope in his amendment. But, more commonly, the cataftrophe is not fo fudden. With the diminution of heat and pain, the pulfe falls; the countenance exhibits great diftrefs ; the eye is funk ; the pupil dilated ; fome¬ times delirium continues ; at others, there is great in- fenfibility witli tendency to coma. Vomiting, occafion- ally, continues without intermiffion : at times, however, the ftomach remains tranquil; and this, when there is much cerebral difturbance. “ As the difeafe advances, a difcolouration of the fkin often takes place. It appears in yellow, brown, and livid, patches. This difcolouration never comes on un¬ til the fubfidence of the fymptoms of excitement, how¬ ever early in point of time. It occurs within the paftive haemorrhage from various parts : from the nofe, corners of the eyes, ears, &c. and at the fame time with the black vomiting. This change of colour appears to arife from ecchymofis proceeding from exhauftion of the vis vitae in the capillary veflels of the furface in confequence of pre¬ vious inordinate excitement. It is very diffimilar from the bilious yellownefs already noticed as an incidental fymptom of the firlt ftage of the difeafe. “ The firft difeharges from the ftomach are merely the ingefta; afterwards a large quantity of ferous fluid is ejected, when little has been drunk. In a more advan¬ ced ftage of the complaint, the material' thrown up is ropy, and mixed with numerous fmall ffreds, flocculi, or membranaceous films, which float in the ejefiied liquid. Thefe loon acquire a dark-brown, purple, or black, co¬ lour ; but do not, at firft, communicate much general tint to the fluid in which they are fufpended. After¬ wards, the matters vomited are more intimately mixed together ; and, with the addition of dark-coloured blood which is effufed into the ftomach, vitiated bile, and other morbid fecretions, give an appearance in the aggregate of coffee-grounds. There is at this period, ufually, a purg¬ ing of dark-coloured matter refembling tar mixed with black blood, “ Sometimes within the firft forty hours, at others af¬ ter a more protrafled period, the feene draws towards a clofe with the ordinary phenomena of approaching di Ab¬ lution which accompany the laft ftages of acute difeafe in general. There. are dilated pupil, ftrabifmus, ftngul- tus. fubfultus teadinum, conxsudeliquium, hemorrhage VOL, XIX. No. 1*99, ' 0 from various channels, fupprefiion of urine, low mutter¬ ing delirium, total infenfibility, occaflonally violent raving, and an inceflant difpofition to rife in bed. Thefe are among the laft fymptoms of an unfubdued attack; and they mark the near approach of death.” To eftablifh our aflertion of the identity of the various forms of yellow fever, we Ihall now give a defeription of this fever as it occurs in the eaft and other parts. In many parts of the eaft, the comforts and habits of the people are far from proving fuch powerful predifpofing caufes of yellow fever as in the weft ; but, as this is by no means general, we often meet with the precife fymptoms of continued fever, as exemplified in the following excel¬ lent defeription of the endemic of Batavia, drawn up by Wade Shields. “The patient, without much previous notice (of the firft attack), is fuddenly feized with gid- dinefs and cold chills, a fenfe of debility, and vomiting, with pain over the orbits, and in the epigaftric region. He frequently falls down, and is infenfible during the pa- roxyfm ; his body covered with cold clammy fweats, except at the pit of the ftomach, zvhich always feels hot to the palm of the hand ; the pulfe is fmall and quick. On re¬ covering a little, this train of fymptoms is fucceeded by flulhings of heat, increafed pain over the orbits and in the linciput, pain and a fenfe of internal heat about the ftomach and prsecordia, oppreffed breathing; the lower extremities, at this time, not unfrequently covered with cold fweats. The eyes now become, as it were, protru¬ ded, and the countenance fluffed. Retching, and, at length, vomiting of difcoloured bilious matter, comes on ; the tongue white and furred, the abdomen tenfe and full, with pain in the loins and lower extremities. The length of this paroxyfm varied from fix to eighteen hours, and was generally fucceeded by cold rigors ; very often low delirium, preparatory to the next ftage or pa¬ roxyfm of the fever. The intellectual functions now be¬ come much impaired, the patient not being at all fenfible of his fituation, or of any particular ailment. If alked, how he is ? he commonly anfvvers, “Very well;” and feems furprifed at the queftion. This was a very dan¬ gerous fymptom, few recovering in whom it appeared. In this ftage all the fymptoms become gradually, often rapidly, aggravated; particularly, the head-ache, pain and tenfion in the epigaftric region, and vomiting. Some patients, on-ffore, were carried off in eighteen, twenty- four, thirty, or forty, hours, and others not till as many days after the attack, efpecially when removed on-board, from the more noxious air of the ifland. A great pro¬ portion changed, in a few days, to a bright yellow ; fome to a leaden colour: other cafes terminated fatally, in a very rapid manner too, without the flighted: alteration in that refpeCh Generally, however, the change of colour indicated great danger. Vomiting of black bilious Huff, refembling the grounds of coffee, trequently commenced early, and continued a raoft diftrefling fymptom 5 too often baffling all our attempts to relieve it. In fome, a purging of vitiated bile, or matter refembling that which was vomited, occurred ; in a great many, a torpor pre¬ vailed throughout the inteftinal canal ; rarely did any natural fseces appear fpontaneoufiy. The pupil of the eye was often dilated, and would not contraft on expofure to a ftrong light 5 in others there was great intolerance of light: both indicated danger. Low delirium was a pretty eonftant attendant on this fever, from firft to laft; fometimes, though more rarely, raging-high delirium. The latter cafe is attended with red, inflamed, and pro¬ truded, eyes; great inquietude, hot dry Ikin, and fmall quick pulfe. The patient’s mind is aftively employed about his ufual occupations. During the violence of the paroxyfms, he is quite infenfible to every thing that goes on around him, conftantly grafping at, or wrench¬ ing, objefls within his reach. In the low delirium, alfo, the mind is much occupied on avocational fubjefts : if a feaman, about the fhip’s duty ; if a foldier, about hk re¬ giment, marching, &c. Some patients were comatofe 3 & from 2.20 , \ PATHOLOG Y. from the fi r A attack ; in others, the fever was uthered in with convulsions, delirium, and cold fweats, without any intervening heat of the furface, except at the pit of the 1 to macli, which, in mod cafes, was burning-hot to the touch, and accompanied internally by a fimilar fen- fation according to the patient’s own feelings. ‘'Haemorrhage from the mouth or nofe feldotn occurred; in two cafes, which terminated fatally, the blood did not coagdlate, but tinged the linen yellow. Aphthae appeared in a few cafes, and indicated danger. Subfultus tendinum often attended both on the low and high de¬ lirium. The pulfe never could be depended on. In the very laft ffage it has been regular ; but in general it is finall, quick, and either hard or ftringy and tremulous ; fometimes, during the reaction of the fyftem, full and hard. Deafnefs was very common, and an unfavourable fymptom. Two kinds of eruption appeared about the lips : one fuch as we often fee at the decline of common fevers; the other, confided of fmall black or brown fpots round the lips, and w’as likewife a dangerous, in¬ deed a fatal, fymptom. With this eruption, the teeth, tongue, and fauces, generally become covered with a brown or black cruft, and the breath intolerably fetid. Locked jaw took place in two cafes at Onruftffiofpital, but the patients were infenfible of it: both died. The brain appeared the organ chiefly affe&ed at firft — the ftomach and liver in fucceflion. In thofe cafes which occurred on-board, and where the patient had not flept on-fliore at Edam, the fymptoms were much milder, and the fever refembled more the bilious remittent of other parts of the Eaft. A great torpor prevails generally throughout the fyftem, with the low delirium ; blifters, medicines, &c. having little effefl on the patient, who appears as if intoxicated. When roufed, he recollects the perfon who is fpeaking to him, for a moment, and anfwers in a hurried incoherent manner: then lies on his back, his mouth and eyes half open ; both feces and urine often parting involuntarily. I have feentpatients remain in this ltate for hours, nay,' for days together, fcarcely moving a Angle voluntary mufcle all that time. Never was there a difeafe fo deceitful as this fever: I have frequently feen inftances where every fymptom was fo favourable, that I could almoft have pronounced my patient out of danger: when all at once he would be leized with reftleffnefs, black vomiting, delirium, and convulflons, which, in a few hours, would hurry him out of exiftence ! The fatal terminations generally happened on the third, fifth, feventh, ninth, and not unfrequently the eleventh and thirteenth, day; if they parted this period, they ufually lingered out twenty or thirty days. But very few indeed ever ultimately reco¬ vered, who had flept on-fhore, and were attacked at that dreadful ifland, Edam ! No conrtitution was exempted from the aflault of this fever. It feized with equal or nearly equal violence on thofe who had been many years in India, and on the mod robuft and plethoric, or newly- arrived, European. Even the Dutch officers and Malays, who had been drawn from different parts of Java, and whom we had prifoners at Edam, fell viftims as fall, or nearly fo, as the Englifh. Several officers, feamen, and foldiers, were fent on-board from this ifland, in hopes that the change of air might mitigate the difeafe. Many » of even the worft cafes of thefe would promife fair for a few hours in the forenoon ; but night always difpelled our hopes, for then the patient relapfed as bad as ever: they almoft all died. But their fate was confiderably pro- craftinated by the change ; many of them lingering out a great length of time on-board, finking at laft from the confequences of the fever, rather than from the fever itfelf. Several of them changed into obftinate intermit- tents at fea, with great derangement of the liver, fpleen, and bowels. Indeed the liver, in moft cafes, feemed af- fefted from firft to laft in this fever ; but, in all protradled ftates of it, this affeftion became the prominent fymptom. In thofe that were cut off during the firft eighteen, twen¬ ty-four, or thirty, hours, the bra'm appeared to be the organ opprefled.” The remittent form of yellow fever is that moft fre¬ quently met with in the Eaft. We (hall accordingly pro¬ ceed to defcribe the marfh remittent, or endemic fever of Bengal, in the words of Dr. Clark. “This fever at¬ tacked in various ways, but commonly began with ri¬ gors, pain and ficknefs at ftomacii ; vomiting, head-ache, oppreffion on the praecordia, and great dejection of fpi- rits. Sometimes, without any previous indifpofition, the patients fell down in a deliquium, during the continu¬ ance of which the countenance was very pale and gloomy; as they began to recover from the fit, they exprefied the pain they fuffered by applying their hands to the fto- mach and head ;” fo great indeed, that delirium often came on at once; but, “after vomiting a conliderable quantity of bile, they foon returned to their fenfes. Sometimes the attack was fo fudden and attended with fuch excruciating pain in the ftomach, that I have been obliged to give an opiate immediately. “In whatever form the difeafe appeared at firft, the pulfe was fmall, feeble, and quick : the pain at the fto¬ mach increafed, and the vomiting continued. As the paroXyfm advanced, the countenance became flufhed,the pulfe quick and full, the eyes red, tongue furred, thirft intenfe, head-ache violent; delirium fucceeded ; and the patient became unmanageable ; but a profufe fvveat breaking out in twelve or fourteen hours, generally mi¬ tigated all the fymptoms. In the retniffions, the pulfe, which before was frequently 130, fell to 90. The patient returned to his fenfes, but complained of great debility, ficknefs at ftomach, and bitter tafte in the mouth. This interval, which was very fliort, was fucceeded by another psroxyfm, in which ali the former fymptoms were ag¬ gravated, particularly the thirft, delirium, pain at the ftomach, and vomiting of bile. If the difeafe was neg- ledfted in the beginning, the remiffions totally difappeared, and the (kin now became moift and clammy ; the pulfe was fmall and irregular, the tongue black and crufted, and the pain at the ftomach and vomiting of bile became more violent.” It is needlefs to fay, that from this period till death clofed the fcene, the features of this fever were fuch as charafterife the laft moments of all violent and fatal fevers. The unfavourable terminations are generally between the third and feventh day, though in fome cafes the fever goes on to the fifteenth or twentieth day: but vifceral obftrudtions are almoft always the confequence ; and he¬ patitis and dyferitery complete what the fever fails to accotnplifh. Dr. Johnfon adds, that feveral cafes oc¬ curred under his infpeftion where there was a yellowifli fufFufion on the fkin, as in the endemic of the Weft, with vomiting of matter bearing a conliderable fimilarity to the grounds of coffee. This however is by no means an uncommon fymptom in the fevers of the Eaft. Occafionally, in the advanced feafon of the year, or when cold weather fets in, this fever aflumes an inter¬ mittent form. The fimilarity in the nature of the two forms of difeafe is well fupported by a Report drawn up by Drs. Ainflie, Smith, and Chriftie, on the epidemic fever of Coimbatore. The Report ftates, that it was either remittent or intermittent, according to theconfti- tution, treatment, and feafon of the year. People by nature delicate and irritable, or rendered fo by irregula¬ rities or want of care, were fometimes attacked by the difeafe in the remittent form, proving bilious or nervous, as the conftitution inclined. “The fame happens to the more robuft, when improperly treated, as where bark is given early and before proper evacuations have been premifed. As the feafon becomes hotter too, the remit¬ tent form prevails overthe intermittent. Males fuffered more than females, and young people and thofe of mid¬ dle-age more than old people and children. The remit¬ tent form fometimes makes its approach very infidioufly. The patient feels himfelf out of forts for a few days ; his appetite P A T II O L O G Y. 221 appetite fails him; he has fqueamiftinefs, efpe.cially at the light of animal food ; univerfal laflitude; alternate heats and chills ; ftupid heavinefs, if not pain in the head. The eyes are clouded ; the ears ring ; the bowels are in¬ variably coftive. In other cafes, the enemy approaches rapidly ; and rigors, great proftration of ftrength, verti¬ go, naufea, or vomiting, ufher in the difeafe. “The fii'lt paroxyfm, which is often attended with de¬ lirium and epiftaxis, after continuing an indefinite pe¬ riod with varying fymptoms, terminates in a fweat ; not profufe and fluent, as after a regular hot fit of ague, but clammy and partial, with the effeft, however, of lowering the pulfe and cooling the body, but not to the natural Itandard. The latter ftill feels dry and uncom¬ fortable ; the pulfe continuing fmaller and quicker than it ought. This remiflion will not be of long Handing, without proper remedial meafures. A more fevere parox¬ yfm fconenfues, ufliered in by vomiting (fometimes of bile), and quickly followed by exceflive heat ; delirium ; great thirlt ; difficult refpiration; febrile anxiety; parched and brownifh tongue. The next remiflion (if it do take place) is lefs perfect than the firft, and brings ftill lefs relief. In this way, if medicine or a fponta- necus purging do not check the difeafe, it will run its fatal courfe, each fucceeding attack proving worfe than its predecefibr, till exhaufted nature begins to give way. The pulfe declines; the countenance fhrinks, and looks fallow ; the eyes become dim, the abdomen fwells from vif- ceral congeftion ; the ftomach loathes all food, when hic¬ cup, ftupor, and low delirium, ufher in death. Such fe¬ vere cafes, the committee think, were, -in general, owing to neglect or blunders at the beginning of the difeafe.” Between the bilious fever and the continued form of the weftern endemic we obferve little difference. In eacii, gaftric irritability, inflammation or fullnefs of the abdo¬ minal vifcera, oppreflion of the head, are for the mod part prefent. The other febrile fymptoms are by no means conftant and regular. Thus the pulfe is frequently re¬ gular, and fometimes up to 120 or 130 in the minute. It is the fame with the temperature of the fkin. Often, when mad delirium is prefent, the pulfe will be 86, and the thermometer in the axilla at 96° of Fahrenheit. The "bowels are almoft always conftipated, or in a ftate of dy- fenteric irritation. No fuch thing as natural flools in this fever are ever to be feen, unlefs procured by art. Frequently, but not always, yellownefs of the eyes, and even of the fkin, takes place ; and the mental functions are very generally affefted, which indeed is charafteriftic of all bilious difeafes. The following is the tnoft general order in which the febrile phenomena prefent themfelves. Severe pain in the head, arms, loins, and lower extremities; ftridture acrofs the bread, with great pain under the fcrobiculus cordis ; retching and griping. In fome cafes the pulfe intermits, and the temperature of the fkin is increafed ; in others, cold chills come on, attended with partial clammy fweats ; but all patients complain of pain under the frontal bone ; molt have white furred tongues, and third. An increafe rapidly takes place in the leverity of the pain in the head, limbs, loins, and acrofs the epigaf- tric region ; condant vomiting of vifcid bile comes on ; intermiffion of pulfe goes off. In fome, the fkin is cold ; in others hot, with infatiable third. Tongue, in mod cafes, covered with a thick white crud. Great irritabi¬ lity of the ffomach, and averfion to food. Bowels con¬ ftipated ; but a few patients have a fcetid bilious purging. The third or fourth days bring an increafe of pains acrofs the epigaftric region, and in the head, with fre¬ quent vomiting of bile ; tongue fwelled and furred, but no great heat or acceleration of pulfe. An increafe of all thefe fymptoms, efpecially the violent pain in the head under the frontal bone, takes place; delirium, and yellownefs of the fkin, come on ; and the fatal progrefs of the difeafe is precifely flmilar to that of the continued fever before detailed. Throughout the whole of the dif¬ eafe, the liver appears to be feverely affected. The difeafe does not always proceed, however, in the manner here mentioned. Sometimes violent madnefs is the firft decided lymptom : the patient endeavours to commit fuicide, and lias been known to attack with fury thofe who have endeavoured to prevent his throwing liimfelf over-board, or committing fimilar acts of violence. The patient often falls fuddenly down, with fuffufed eyes and infenfibie limbs ; and awakes after fome time to undergo the molt violent inflammation of the brain. The appearances found on dijfcdling thofe to whom yellow fever has proved fatal, are fuch as commonly fol¬ low inflammatory aflion ; and, according as this aftion has been violent or otherwife, we obferve the various gra¬ dations of mortification or (laughing, of abfcefs or ulce¬ ration, of adhefion or effufion, or (rarely) of Ample red- nefs and dilatation of veffeis. The parts principally affected are, the brain, the mem¬ branes of which are often found adhering together, and the ventricles containing watery or bloody fluids,; the liver, the ftruftureof which is varioufly affected, from a flight hardnefs and darkened colour of its edge, to a ftate fo completely diflblved and broken down, that with the flighted preffure the finger runs into if. The gall-blad¬ der is almoft always turgid with bile; the ftomach and fmaller inteftines inflamed in various degrees, the fto¬ mach being frequently ulcerated or fphacelated, and the inteftines exhibiting various difeafed products : it rarely happens that the inflammation extends to the colon. The thoracic vifcera are not generally much aflefted, though occafionally polypi arefound forming in the heart, or the pericardium is unufually diftended. But ulce¬ ration or abfcefs of the lungs is perhaps the- lead fre¬ quent organic lefion of the vifcera. The fkin is often affefted with inflammatory aftion, as exemplified by its frequent termination in (pots and ecchymofes. It is to be remarked, that fometimes the abdominal vifcera are very much difeafed, while the brain is tolerably found : but much variety exifts as to the organs affefted. We pafs over numerous hiftories of the forms of yel¬ low fever. We have dated what appear to us the princi¬ pal divifions. To attempt to detail the perpetually- changing varieties in febrile difeafe is equally beyond our limits or our power ; fora hiftory, fo far complete, that it embraces all the forms of yellow fever that have hi¬ therto appeared, we again refer our readers to the work of Dr. J. Johnlon, before quoted, and to which we have been much indebted in our compilation of the hiftory of this difeafe. The courfe of few maladies fo ftrongly exemplifies the danger of following with unvarying meafures difeafes fimilarly named as that of the yellow fever. The treat¬ ment of this difeafe muft change according to the pre¬ valence of particular fymptoms, according to the mode of attack, and according to the efteifls it produces. It cannot uniformly be grounded on the divilion of ftages, fo ufeful in moll ailments ; for we have before feen, that it fets in in various and oppofite ways ; being fometimes attended with coldnefs and diminution of all the phenomena of life ; fometimes, on the contrary, with raving delirium, and great exaltation of ftrength, heat, &c. It cannot altogether be founded on the exci¬ ting caufe; for the intenfer and the milder forms equally arife from the aftion of the fame agent, if the conftitu- tion be different; nor can an obfervance of the conftitu- tion of the patient always lead us to difcrimination, fine* the weakeft patients have borne depletory meafures un¬ der which the robuft have funk, and of courfe vice verfa. The firft acceflion of the fever being the period at which alone remedial agents can be depended on, it be¬ hoves us to meet it with the utmoft promptitude and de- cilion. If the cold ftage be firft manifelted, we (hould lofe no time in putting in force thofe meafures of bleed¬ ing/. 222 PATHOLOGY. ing en the one hand, and reftoring the balance of cir¬ culation on the other, as detailed in the quotation from Dr. Jackfon in our 209th page. If the raving delirium and increafed circulation be firft manifeft, our bleeding nudt .be ftill more free; and here let us caution our pro- feffional brethren againft thofe futile half-meafures which fyftematic writers in this country have been accuftomed to recommend. We repeat the opinion of the beft-in- formed practical writers on Indian maladies, when we quote Dr. J. Johnfon’s exprefiion “ Bleed boldly and de- cilively'till the head and prtecordia are relieved, or draw 110 blood whatever.” Indeed it is effedr we muft look to. Thepulfe is fo changeable, that it is a bad guide; and, as to quantity, this is fo various in different perfons of the fame appearance, that the meafurement of ounces is ftill mors fallacious. Ninety ounces of blood have been drawn during the early ftage of this fever; and not until that quantity was extradled did the fymptoms abate. This meafure frequently relieves not only the head and abdominal congeftion and inflammation, but alfo the diftrefling and perpetual vomiting. In pro- iecuting it we muft let nothing deter us from our pur- pofe. Should mental impreflion caufe faintnefs, the pa- rientis to be fupported with a little wine and water; the bleeding reftrained ; and, as foon as animation is reftored, we muft again open the vein. When the head is vio¬ lently affedled, cold lotions are to be applied to it ; and, if there is general and high excitement, water fhould be dallied over the whole body. Againft emetics ftrong tef- timony exifts ; and indeed, when the great irritability of the ftomach is confidered, we fliould naturally fup- pofe fuch remedies muft do harm. The only cafe in which an emetic feems at all allowable, is when a full meal of folid food has been taken foon after the accef- fion of the fever, and the ftomach has not rejedted it. Here it appears highly probable that the undigefted ali¬ ment mult excite more ferious inflammation than the tranuent ftimulus of the emetic. Purgatives in a condenfed form, as calomel with rhu¬ barb and jalap, may be next exhibited ; and thefe Ihould be aflifted in their operation by oleaginous or fa- line enemata. When the irritability of the ftomach is fo great that we fear the rejection of purgatives, a fcru- ple dofe of calomel combined with a grain of opium, is laid to reduce the difpolition to vomit in a rapid and afto- nilhing manner; after which the purgatives may again be perfevered in. When the bowels have been freely eva¬ cuated by purges, we muft have recourfe to calomel, a remedy which writers on this fever have floridly called their “ flieet-anchor.” This medicine, exhibited in large dcfes and combined with opium, has been found to be a remedy of univerfal application. Many have trufted to it alone ; but though with thefe practitioners fome pa¬ tients were cured, and the lives of others confiderably prolonged, yet the rate of mortality which occurred du¬ ring the exclufive ufe of mercury fo far exceeded that which attended the practice of conjoining its exhibition with bleeding, that the latter pradtice is now reforted to in all violent cafes. This fadt may be explained on the ground that abforption does not readily take place when the blood-veffels are full, or on the ground that the ge- nerally-increafed momentum of blood keeps up inflam¬ mation in the capillary fyftem of the difeafed vifcera, notvvithftanaing the favourable adlion of mercury on the fecernents. At all events, it is almoft impoflible to im¬ pregnate the fyftem with mercury till ample depletion lias been ufed. Of the mode of adlion of mercury we have before regretted our ignorance, when fpeaking of cholera and dyfentery. In the fever in queftion, it feems to be chiefly effedtive by eftablifhing general fecretion ; and we find that, when this happy occurrence has taken place, (which is denoted by ptyafifm coming on,) then, and not till then, is the patient in a fair way of recover¬ ing. If the ftomach rejedts the calomel, mercurial in- undiion may be fubftituted. 4 The above-urged meafures ofcourfe require fome mo¬ dification. If the head be more exclufively affedled, and the liver in a trifling degree only, we need not always pufh the mercury to the extent of ptyalifm ; but we fliould carry the bleeding to the higheft pitch, and parti¬ cularly attend to the cold affulion. When the difeafe aftumes the mild remittent or intermittent form, the pa- roxyfm may becondudied by the fame means as before mentioned. During the intermiflion, calomel may be conjoined with bark, and the latter injedled per ano ; but, ever keeping in mind to reftore the adlion of thofe parts which are deficient, and diminifh thofe motions which are exceflive, we fliould endeavour by blifters, by baths, and by local bleeding, to relieve topical inflam¬ mation, and reftore the balance of power of wdiich all the phenomena of this fever indicate a fevere derangement. It is fcarcely neceflary to add, that it is of importance to avoid the exciting caufes of the complaint, fince thefe invariably aggravate it. Thus the removal of loldiers into barracks at a diftance from peftilential effluvia, of tailors from on-board of foul or crowded veflels, &c. fliould, when pradlicable, be ftrongly urged. It is to be remarked, that fome have fuppofed the yellow fever fo be a difeafe which cannot occur twice in the fame indi¬ vidual ; but this is contradidled by the bell authorities. We muft now return to our nofological arrangement, which, for the obvious reafon that it entirely difagrees with the opinions we have adopted as to the identity of feveral fevers diftindtly named, we have thus far aban¬ doned. Dr. Good gives in the prefent order of Pyrexia; four genera. Genus I. Ephemera, [from the Gr. '^utpa, a day.] Ephemeral, diary, or Ample, fever. Generic charadters — Attack fudden ; paroxyfm fingle, and terminating in about twenty-four hours. There are three fpecies. 1. Ephemera niitis, or mild ephemera : without prece¬ ding rigor; heat and number of the pulfe increafed flightly; laffitude and debility inconfiderable ; pains ob- tufe, chiefly about the head ; perfpiration and breathing pleafant. This fpecies is ufually produced by excefs of corporeal exertion, ftudy, or violent paffion ; by fup- prelfed perfpiration ; fudden heat or cold. 2. Ephemera acuta, or acute ephemera : fevere rigor; great heat ; pulfe at firft fniall and contradled, after¬ wards quick and ftrong ; perfpiration copious ; great languor. It is frequently produced by a furfeit of eat¬ ing or drinking; or fome temporary organic obftruc- tion. Thefe two fpecies of Ephemera generally go off fpontaneoufly ; or, at nidi, by the help of reft and ab- ftinence. 3. Ephemera fudatoria, the fweating ficknefs : tenfe pains in the neck and extremities ; palpitation ; dyfpncea, pulfe rapid and irregular; heat intenfe ; intolerable thirft ; drowfinefs or delirium ; exceflive fweat. The hiftory of the rife and progrefs of this Angular and formidable difeafe conftitutes one of the moft cu¬ rious articles in the annals of medicine. Its origin is involved in a good deal of obfeurity; and much vague and inconclufive reafoning, concerning the mode in which it was propagated, is to be met with even among the moft authentic authors who deferibe its ravages. It feems, however, to be generally admitted, that it firft appeared in the army of the earl of Richmond, after¬ wards king Henry VII. upon his landing at Milford Haven, in 1485 ; and that it foon fpread to London, where it raged from the beginning of Auguft to the end of Odtober. Whether the troops, which were foreign foldiers, levied by the earl of Richmond, brought the difeafe with them from the continent, or whether the contagion was generated in the crowded tranfport-yef- fels on-board of which they were embarked, it is irn- pofflble, amidft the deficiency of evidence, to determine. It may readily be fuppofed, however, that a highly ma¬ lignant and contagious difeafe might have been generated under PATHOLOGY. under thefe circumftances, efpecially as this body of troops is defcribed by a contemporary hiftorian (Philip de Comines) as the moft wretched he had ever beheld ; col- ledred, it is probable, from jails and hofpitals, and bu¬ ried in filth. The mod general opinion at the time, how¬ ever, certainly appears to have been, that it arofe from i'ome peculiar ftate of the atmofphere, and was propaga¬ ted by contagion ; but no writer has diltinftly pointed out the connexion of this or of any other epidemic with a fpecific condition of the air, nor detedfed any pe¬ culiarity in the circumftances attending its fil'd appear¬ ance, or fubfequent returns. The fweating-ficknefs broke out in England four dif¬ ferent times after this, but at unequal intervals. The fummer feafon was always the period of its commence¬ ment, and it continued rife from three to five months. It appeared during the fummer of 1506; and again in 7517, from July to the middle of December; when it raged with peculiar violence, proving fatal in the courfe of three hours ; extending its havock to many of the no¬ bility, and carrying off, in many towns, half the inha¬ bitants. Its next recurrence was in 1528; at which time, though it was fomewhat lefs fatal, many ot the courtiers of Henry VIII. fell viftims to it, and that mo¬ narch himfelf was in danger. Eellay, bifhop of Bayonne, then ambaflador in England, who was affedled with it, reports, that of 40,000 perfons attacked with it in Lon¬ don, only 2000 died. The lad time that it vifited Eng¬ land was in 1551, when its fatality was fo great, that in Wedminder 120 died of it in a day, and among others, the two fons of Charles Brandon, both dukes of Suffolk. In Shrewfbury, particularly, according to the tedimony of Dr. Caius, who refided in that city, 960 died within a few days. The diforder had alfo, in the mean time, been defolating many parts of the continent. "In 1 529 it fird fltowed itfelf in Holland, and thence fpread to the Nether¬ lands, and to Germany, dedroying a great number of lives. It is dated to have interrupted a conference at Marpurg between Luther and Zuinglius, about the eu- charid. From the defcription which Wierus has given us of this epidemic, as it appeared in Germany, it leems to have commenced with a violent cold dage and fiiivering, which continued half an hour or more, accompanied with great pains in the region of the diaphragm and groin, and the other fymptoms already mentioned as charafler- izing the difeafe, when obferved in England. Swelling and diffnefs of the hands at the beginning of the attack, and vomiting of black blood or bile, are alfo noticed by this author in particular. Erafmus, an eye-witnefs of its devaluations, defcribesit in very forcible terms, v vifum ed ax amne Phlegetoneo emifi'um hoc malum.” Thisdifeafe has been defcribed by various writers under the names of fudor Avglicus, ephemera Brit.annica, ephe¬ mera fudatoria, RydronoJ'ns, and hydropyrctos. It appears from their accounts to have fpared no age or condition, but to have attacked more efpecially perfons in high health, of middle age, and of better rank and condition. The invafion of the difeafe was exceedingly fudden, and was marked by the affection offome particular part, pro¬ ducing thefenfation of intenfe heat, extending through the limb, atid afterwards diffufing itfelf over the whole body. This was immediately followed by profufe fweat- ing, which generally continued more or lei's through the whole courfe of the difeafe, and was attended with infa- tiable thirft. Extreme reltleflhefs, head-ache, delirium, naufea, cardialgia, and an irrefiftible properifity to jleep, chara&erized itsprogrefs; together with great proftration of ftrength, producing frequent fainting, and irregula¬ rity in the aflion of the heart, which fometimes palpi¬ tated violently, while at other times the pulfe was weak and fluttering. In this way the patient was carried off frequently in two, three, or four, hours from the erup¬ tion of the fweat. Thofe more efpecially who bore their Jufterings with impatience, and who fought relief from the fen fe of heat, by which they were tormented, by ex- Vql. XIX. No. 1299. 223 pofing their bodies to the air, or even by putting their arms out of bed, were often fuddenly ftruck with death. The fweat, when promoted, is represented as being un- ufually clammy, as well as abundant, and as having a very ftrong and peculiarly fetid odour. The violence of the attack generally fubfided in fifteen hours, yet the pa¬ tient was not out of danger till the expiration of twenty- four hours. For a long time phyficians were at a lofs how to treat this new and Angular malady. The fatal effedfs of expo- fure to cold, however, fuggefted the propriety of accumu¬ lating heat round the patient, with a view of promoting the fweat, which appeared fo manifeftly to be a critical difcharge. The moment a perfon was feized with the fymptoms of the difeafe, he was to lie down immedi¬ ately in bed, without taking off his clothes, and to be completely covered, all but the face, with bed-clothes; in which fituation he was to remain perfectly ftili, not ftirring a limb, if pofiible, nor putting a hand out of bed, He was enjoined abltinence from food during the whole twenty-four hours, and even from drink the firft five hours : then a little ale or beer, or wine and water, was to be given in fmall portions, and fucked through a fpout, the patient ftili lying in the fame pofture. At the expiration of about fourteen hours, the bed-clothes were gradually to be removed, and the fweating reftrained ; and, after it was quite over, proper food was to be given to recruit the exhaufted ftrength. This was the procefs when the fweat flowed fpontaneoufly : when this was not the cafe, attempts were made to excite it, fuch as by dry and warm frictions, wine, aromatics, vinegar - whey, China-root, and other fudorific medicines. By this me¬ thod of 'praftice, actively purfued, and properly adapted to the circumftances, we are told that the difeafe, though fo fatal when neglefted or mifmanaged, was got over with a tolerable certainty of fuccefs; fo that, according to the obfervations of lord Bacon, who has given us a lltort account of it in his Hiftory of Henry VII. it might be looked upon “ rather as a furprife of nature, than obftinate to remedies.” Great ftrefs is laid by fome phy¬ ficians on the danger of indulging the propenfity to deep which accompanies the paroxyfin. “If they were fuf- fered to fleep,” fays Cogan, “ commonly they fwooned, and fo departed, or elfe immediately upon their waking.” (Haven of Health, p. 262.) It appeared, however, from the teftimony of the continental phyficians efpecially, that much harm, and frequently fatal confequences, arofe from the extremes to which the hot regimen was carried. Dr. Willan, in his publication on cutaneous difeafes, has thrown out a fuggeftion concerning the origin of this affection, which he fuppofes might have been owing to fome difeafe or depravation in wheat, or to fome noxious vegetable growing with it in particular fituations. This idea feems to have been fuggefted by fome analogy to be traced between the fatal epidemic, called feu facre, feu St. Antoine, mal des ardens, See. which is fuppofed to have originated from eating rye damaged by a parafitic plant, conftituting the diforder in corn termed by the French ergot ; and it was alleged, that the inhabitants of Wales and Scotland who fed on barley or oat bread, were not attacked. This opinion appears, however, to be unte¬ nable, and has been ably combated in a paper in the Edinburgh Medical Journal, vol. iv. p. 464. In a curious and fcarce book, called the Touchftone of Complexions, firft printed in 1633, we have the opinion of Dr. Ltevinus Lemnius, the famous German philofo- pher, who vifited this country at the beginning of tire 16th century, as to. why the fweating-ficknefs fliould prevail here more than elfewhere. It will be feen by the following extradl, that we have been long and commonly regarded by foreigners as a gluttonous nation. “ The ephemera, or diaria, is the fweating-ficknefs, which, be- caufe it began in England, is called the Englijh fweat. Why this difeafe is termed by the name of the Englilh 224 PATHOLOGY. fweat, I fuppofe grew hereupon, for that the people of that country be often therewith attacked, partly through their curious and dainty fare, and great abundance of meats, wherewith they crarnme themfelves very inglu- vioufly, which I noted at my late being in that realme, (about the time of midfummer,) by reafon that the ayre with them is troubled, cloudy, and many times with foggy dampes overcaft, whereby is engendred the caufe and originall, both inwardly and outv/ardly, of this dif- eafe ; the vehemency whereof' bringeth them into a bloody fweating, wherewith they muft wreftle and drive as with a molt fierce and ftrong enemy, ..and which they muft en¬ deavour with all might to fupplant : hereupon happen trannces and fwounings, through feeblenefle of body and minde, fainting and drooping of the fpirits, decay of powers, flopping of the pipes and voyce, and life almoft thereby cleane yeelded up, and the party even brought unto death’s doore.” Other books from which original information may be collefted on the fubjeft of this article are the following : A Boke or Confeill againft the Difeafe commonly called the Sweat or Sweating-Sicknefs, made by John Caius, Doftor in Phyfic, 1552, nmo. which was afterwards re¬ viled, enlarged, and put into a more fcientific form, by the author, and publiflied in Latin, in 1556, under the title of De Ephemera Eritannicu. Joh. Wierus, De Su- dore Anglico. C. V. Dubourghdieu, De Pefte. Forref- fus, Schol. Obferv. vi. B. Sennertus, iv. 15. Thomas Cogan’s Haven of Health. Lord Bacon’s Relation of the Sweating-ficknefs examined, &c. by Henry Stubbe, Phyfician at Warwick, 4to. Lond. 1671. R. Fortis, Ephemera Anglica Peftilens. Genus II. Anelus, [from aviy/xi, I intermit.] Intermit¬ tent ague, or fever. Generic characters' — Paroxyfm in¬ termitting, and returning during the courfe of the dif- eafe : the intermiffion generally perfect and regular. There cannot perhaps be ftronger evidence againft the notion that local inflammation is the invariable accompa¬ niment of fever, than that derived from the occurrence of intermittents. In thefe difeafes, a cold paroxyfm fol¬ lowed by a hot one, each more fevere than in continued fever, leaves the patient perfeftly free for fome time from pain, or indeed lofs of ftrength or derangement of func¬ tion. Neverthelefs, according to Brouflais, thefe fevers are, equally with thofe of the continued form, gafiro- enterites. But any one not blinded by a favourite hypo- thefis, cannot fail to view intermittents rather in the light of irritative than inflammatory affections ; that is to fay, as difeafes in which the nervous fyftem is primarily affefted, and the capillary fyftem fecondarily and as a confequence. But the reafon why intermifllons take place is the difficult point to be decided. Darwin endea¬ voured to refer thefe periodical changes to the influence of our diurnal habits, in regard to aftivity and fleep, exhauftion of fenforial power and invigoration, and to the diurnal periods of heat and cold, light and darknefs, & c. upon all the actions of our frame. That thefe cir- cumftances greatly influence the operations of the animal body, cannot be doubted : and, were all the periods of aftion and intern\iflion diurnal only, we might admit the generalization as correct. But we cannot reconcile the very frequent intermiffions of difeafe, which continue for tertian periods, that is, during an interval of forty-eight hours, and ftill more thofe which continue for quartan periods, of feventy-two hours, with this general law. See Zoonomia , vol. ii. feft. 36. The French writers (among whom the names Begin and Mongellaz occur to us at prefent) have fpeculated of late as to the caufe of intermittents. But, though thefe gentlemen have detailed fome remarkable obferva- tions concerning the laws of intermittents, we do not find any rational attempt at inveftigating the reafon of the intermiflion. Dr. Park, in his Gulftonian Lecture, dated very properly, that irritation was the caufe of the 4 fevers in queftion ; and he founded his explanation of the caufe of intermiffion on this aflumption ; viz. that the effects of irritation vary according to the mode in which it is applied ; “that which is internal to the organs ex¬ citing increafed contraction ; while that which is external diminifties or fufpends it.” “ Beginning with internal irritation, its immediate ef- feft is to excite the organs to increafed contraction, as the following examples may (how. Thus, emetics ex¬ cite increafed contraction in the ftomach; purgatives in- creafe contraction in the inteftines ; fudorifics ftimulate the exhalent veflels to contract,” &c. On the other hand, our author infers that the influence of external irritation is to fufpend or diminifti contrac¬ tion, becaufe, “in afteCtions of the ftomach or inteftines, rubefacients or blifters, externally applied, are ufed for this purpofe. In morbid irritability of the womb, fric¬ tions and fomentations have that effeft. In the vafcular fyftem, the influence of external irritation is obvious and vifible on the furface, in the relaxation and increafed fulnefs of veflels produced by it, in whatever mode it is applied; whether mechanically, as by rubbing, lcratch- ing, or bruifing ; or phyfically, as by the application of finapifms, increafed fulnefs and diftention of the veflels being invariably the effeft that refults. And in the fame way relaxation and increafed fulnefs of the veflels is pro¬ duced by ftrong ftimulants applied to the internal fur- face of the ftomach, where they aft externally to the veL fels ramified on that furface ; hence the general glow and fenfe of warmth that arife from taking wine or ardent fpirits.” The application of the above-mentioned propofition to the phenomena of intermittent fever is as follows. The firft caufe, whether marfti-miafma or any thing elfe being admitted to the mucous membranes, aCts as a ftimulant (according to Dr. Park caufing relaxation) externally to thefe veflels; and hence the unufual flow of fpirits which often precedes a febrile attack. As foon, however as this agent is abforbed, and carried into the circulation, it ex¬ cites increafed contraction, (according to Dr. Park with diminilhed circulation ;) and hence the cold fit. “The duration of this cold ftage (fays Dr. Park) is limited, becaufe the powers of aftion are limited ; and, the more violent the contraction, the fooner thofe powers will be exhaufted. The duration of the hot ftage is limited, be¬ caufe the relaxation of veflels which occafions it arifes folely from their previous over-aftion, and not from any perfonal debility.” The fweat ing-Jlage is referred by our author, accord- ing-to an hypothefis before mentioned, when fpeaking of continued fever, to the relaxation of the fph in diet'- like extremities of the capillaries, thefe veflels having reco¬ vered their natural dimenfions after the expiration of the hot ftage. The beneficial operation of the fweating-ftage is dependant, in the firft place, on a reduction of irritabi¬ lity attendant upon a copious depletion of the veflels ; and, fecondly, on the partial expulfion of the irritating caufe : “the quantity of which muft be diminilhed with every paroxyfm ; one portion being thrown off- by tranf- piration, while another is returned back into the primae viae, where it no longer afts internally to the veflels, and therefore no longer excites them to contraftion.” The paroxyfm, however, recurs after a certain period; “ be- cauf^ the portion that remains will be again taken up by abforption, and be internally applied to the veflels; where its ftrength will gradually accumulate, until it ac¬ quires force enough to excite another paroxyfm ; and thus the fever affumes the intermittent form.” Now it is obvious, that, according to the rapidity of this accumulation of the agent of the fever, fo will the difeafe be quotidian, tertian, quartan, &c. Dr. Park likewife attributes fomewhat of the fecond and follow¬ ing attacks of ague to an accumulation of excitability, which he fays predifpofes the body to be more ftrongiy afted on by flighter caufes ; for, if this accumulation did not 225 PATHOLOGY. not take place, the miafmatal irritant being thrown off gradually by perfpiration and other fecretions, the pa- roxyfms would always become milder as the difeafe ad¬ vanced. But this is not the cafe. This liypothefis, though far from being correft, ap¬ pears to us the beft yet promulgated ; and the hint de¬ rived from it fee ms to us to ferve as the foundation for a theory more confonant with acknowledged faffs. We mean, that the idea of accumulation of material agents maybe explained without the affumptiou (an affumption which a thoufand fafts deny) that internal irritants ex¬ cite, while external irritants diminifli, contra flility. We •Ihould rather fuppofe the following circumftances take place: that the miafma, or other caufe of ague, operates exclufively on the mucous membrane, it may be, of the Itomach or lungs, but we know not where : it may be conjeftured, however, on the Itomach ; that the irritation it excites is direftly tranffnitted to the brain and nervous fyftem in general, through the medium of which, as in continued fever, the capillaries are fo affefted as to pro¬ duce fever. Abforption of the miafma taking place, this irritation is no longer kept up on the nerves of the mu¬ cous expanfion 5 and, in unifon with the law often urged, a re-aftion takes place over the whole body, merely in confequence of the nervous diminution of motion. Without inferring an aftual accumulation of the miafm, fince that would be difturbed by the paffage of food, &c. we Ihould fay, that a number of imprejfions from the now fecreted miafms were neceffary to develop the fympathetic aflion of fever; and of courfe, as the conftitution was more or lefs irritable, fo would the febrile movements take place in a larger or Ihorter period. There is no ne- ceflity to infer that the quantity of miafm gets lefs, be- caufe we know that fecreting veffels often fecrete the fame irritant as that which caufed their morbid ad ion ; as is exemplified in morbific pains. Left it be faid, how- ever, this is only eftablifhed with regard to animal irri¬ tants, we Ihould account for the unaltered degree of fe¬ ver obferved in fucceeding paroxyfms on the well-known law of habit ; viz. that fympathetic movements are more eafily called into aftion in proportion to the frequency of their previous occurrence. It will be feen that much of this theory belongs in fad to Dr. Park; to whom moreover this much is due, that its ftrudure is entirely owing to the train of thought into which his reafoning has call us. And we fliall endeavour to conned thefe views with an explanation of tic douloureux and other periodical nervous affedions, when we come to the clafs Neurotica. The adions which give rife to the paroxyfms of inter- mittents, though kept up folely by irritation, being ne- verthelefs fimilar in their nature to thofe of continued fevers, it follows, as in other difeafes, that, if the con- tradility of the blood-veffels is impaired, adual inflam¬ mation will arife ; and hence that continued fever will come on, or that a ftate nearly bordering on this, but at the lame time capable of increafe from the periodical adion of the exciting caufe, will occur ; in which cafe we witnefs what is called a remittent fever. Each paroxyfm of an intermittent fever is divided into three different ftages, which are called the cold , the hot, and the fweutivg, Jlages, or jits- 1. The cold Stage commences with languor, a fenfe of debility and lluggilhnefs in motion, frequent yawning and ft retching, and an averfion to food. The face and extremi¬ ties become pale, the features Ihrink, the bulk of every ex¬ ternal part is diminilhed, and the Ikin over the whole body appears conltrided, as if cold had been applied to it. At length the patient feels very cold, and univerfal rigors come on, with pains in the head, back, loins, and joints, naufea and vomiting of bilious matter; the refpi- ration is fmall, frequent, and anxious ; the urine is almoft colourlefs ; fenfibility is greatly impaired ; the thoughts are fomewhat confufed 5 and the pulfe is fmall, frequent. and often irregular. In a few inftances, drowfinefs and ftupor have prevailed in fo high a degree as to referable coma or apoplexy ; but this is by no means ufual. 2. Thefe fymptoms abating after a fhort time, the fe- cond ftage commences with an increafe of heat over the whole body, red n el's of the face, drynefs of the Ikin, thirft, pain in the head, throbbing in the temples, anx¬ iety and reftleffnefs ; the refpiration is fuller and more free, but ftill frequent; the tongue is furred, and the pulfe has become regular, bard, and full. If the at¬ tack has been very fevere, then perhaps delirium will arife. 3. When thefe fymptoms have continued for fome time, a moifture breaks out on the forehead, and by degrees becomes a /meat.; and this, at length, extends over the whole body. As this fweat continues to flow, the heat of the body abates, the thirft ceafes, and molt of the fundtions are reftored to their ordinary ftate. This con- ftitutes the third ftage. It mult, however, be obferved, that in different cafes thefe phenomena may prevail in different degrees, and their mode of fucceffion vary; that the feries of them may be more or lefs complete ; and that the feveral ftages, in the time they occupy, may be in different proportions to one another. Such a depreftion of ftrength has been known to take place on the attack of an intermittent, as to cut off the patient at once ; but an occurrence of this kind is very uncommon. Patients are feldom deftroyed in intermit- tents from general inflammation, or from a fulnefs of the veffels either of the brain or of the thoracic vifeera, as happens fometimes in a continued fever; but, when they continue for any length of time, they are apt to induce other complaints, fuch as dyfpepfia, difeafe of the liver, dropfy, &c. which now and then prove fatal. In warm climates, particularly, intermittents are very apt to ter¬ minate in a fatal manner. When the paroxyfms are of fhort duration, and leave the intervals quite free from fe¬ ver, we may expeft a fpeedy recovery 5 but, when they are long, violent, and attended with much anxiety and delirium, the event will be doubtful. Diffeftions of thofe who have died of an intermittent, fhow a morbid ftate of many of the vifeera of the thorax and abdomen ; but the liver, and organs concerned in the formation of bile, as likewife the mefentery, are thole which are ufually moft affefted. The treatment of an intermittent fever refolves itfelf into thofe means which may be employed during a pa¬ roxyfm to arreft its progrefs, or to mitigate its violence ; and thofe which may prevent any return, and effeft a per¬ manent cure. This forms of courfe the more important part of the plan ; but it is fometimes neceffary to pal¬ liate urgent fymptoms ; and it is always definable to fuf- pend a paroxyfm, if poffible, not only to prevent mil- chief, but alfo that there may be more time for the ule of the moft effeft ual remedies. When therefore a fit is commencing, or (hortly expefted, we may try to obviate it by fome of thofe means which excite movements of an oppofite defeription in the fyftem : an emetic will gene¬ rally anfwer the purpofe, determining the blood power¬ fully to the furface of the body. Should the paroxyfm have already come on, and the cold ftage be very fevere, the warm bath, and cordial diaphoretics in repeated moderate dofes, may aflllt in bringing warmth to the furface : when, on the contrary, great heat prevails, the antiphlogiftic plan is to be purfued; and it is highly ne¬ ceffary, if any organ of importance be much inflamed, to take blood, efpecially if the patient is plethoric and rebuft : acidulated drink may be exhibited, with purges, keeping the furface cool at the fame time. In the inter- millions, ftimuli of various kinds are recommended; at the head of which we place cinchona and arfenic, the former of which is to be taken largely in fubftance, where the difeafe is not complicated with vifceral affec¬ tion 5 in a quotidian an ounce at leaft Ihould be given between PATHOLOGY. 22C, between the fits, in a tertian half as much more, and in a quartan two ounces. It will be generally better to dear out the primre viae before this remedy is begun with; and various additions may often be required, to make it agree better with the ftomach and bowels, parti¬ cularly aromatics and other ftimulants, aperients or fmall dofes of opium, according' to circumftances. In thefe dofes, however, it generally oppreffes the ftomach ; and it may reafonably be doubted whether the application of bark has not often produced the vifceral difeafes which have happened in this complaint. The French ufe a pre¬ paration of this drug- called quinine. It has this advan¬ tage over the cinchona in powder, that it contains all the remedial portion of that fubftance, without difturbing the digeliive procefs by its large quantity of tough woody fibre. The dofe is two grains, to be given every two hours during the intermiftion. The fulphuric acid has been ftated to have proved very fuccefsful in the re¬ moval of this difeafe. But the mod efficacious prepa¬ ration we know of is the liquor arfenicalis : it muft be given in dofes of io or 12 drops two or three times a-d.iy, and it^ effeCts watched. Our readers will bear in mind (fee p. 55 of this arti¬ cle), that the black pepper (in dofes of 6 to 10 grains twice a-day) has been fuccelsfully given by Drs. Frank and Ghighini. Since that paragraph was written, many refpedable teftimonials have appeared in favour of the ufe of this drug. It is remarkable that this is merely an old medicine revived, Diofcorides and Cafimir Medicus having both ufed it in the treatment of intermittents. This complaint often feems kept up by an habitual operation of a&ion after the exciting caufe has ceafed to exift. It is in thefe cafes that fo much has been done by mental impreflions. We might fill a page with an enumeration of the various inert remedies which have, •through the medium of imagination, cured the ague. It will be fufticient to extraCt two fentences from the works of two of the firft philofophers of this country. “ I myfelf,” fays Mr. Boyle, “ was cured of a violent quotidian by applying to my wrifts a pafte made of bay- falt, new’ hops, and blue currants; which has alfo re¬ lieved many others both of quotidians and tertians.” (Philof. Works abr. tom. i. p. 80.) And Lord Bacon lays, that “juices of ftock-gilly flowers, rofe-campion, garlic, and other things, applied to the wrifts, and re¬ newed, have cured long agues.” His lordfliip likewife recommends, in the heats of agues, to hold eggs of ala- bafter and balls of cryftal in the hands. The genus Anetus is divided by Dr. Good into five fpecies, and thole fpecies into many varieties, as will ap¬ pear from the following enumeration. 1. Anetus quotidianus, the quotidian ague : intermif- fion about twenty-four hours; paroxyfm commencing in the morning ; ufual duration under eighteen hours. < This fpecies is fubdivided into the following varie¬ ties. a.. Partialis : confined to a particular part or organ, ufually accompanied with diftrefiing pain. Sometimes limited to one fide. Sometimes, and ftill more generally, confined to the whole or half the head, embracing many cafes of cephalaea. (3. Comitatus : catenated with, or giving rife to, fo¬ reign lymptoms or other difeafes. 7. P rot raQus : leaving the intermiftion inordinately fnort, or imperfeCL 8. Anticipans, the anticipating quotidian of Fordyce : the paroxyfm anticipating its antecedent period ufually by about two hours ; and continuing the fame antici¬ pation at every recurrence ; fo that the accefiion may hereby be thrown into any hour of the day or night. e. Cunftans, the retarding quotidian : the paroxyfm delaying its antecedent period, ufually by about two hours ; and continuing the fame delay at every recur¬ rence as above. 3. Anetus tertianus, the tertian ague: intermiflion about forty-eight hours ; paroxyfm commencing at noon ; ufual duration under twelve hours. Divided into, a. Comitatus : catenated with other difeafes ; and, 13. Protradlus: leaving the intermiftion inordinately ftiort or imperfedh 3. Anetus quartanus, the quartan ague : intermiftion about feventy-twro hours ; paroxyfm commencing in the afternoon ; ufual duration under nine hours. This, like the former, has a., Comitatus ; and /•?, Pro¬ tradlus. Alfo, 7. Anticipans, or anticipating quartan : the paroxyfm anticipating its antecedent period. 8. Cunclans, or retarding quartan : delaying its ante¬ cedent period. 4. Anetus erraticus, the irregular intermittent : inter¬ miftion and paroxyfm lefs regular ; the former more than feveuty-two hour's. This is divided into, cl, Quintanus ; /?, Sextanus; 7, Septanus ; 0, Odtanus; e, Nonanus; £, Decimanus ; and laftly, -/}, Vagus, which is equally irregular in the vio¬ lence of the paroxyfm, the duration of its ftages, and the period of its return. 5. Anetus complicatus, the complicated intermittent : paroxyfms intricate, multiplicate, or both. Here we have no fewer than eight varieties. a. Tertianus duplex, or double tertian. C. Tertianus triplex, or triple tertian. 7. Tertianus impar, unequal double tertian. 8. Tertianus duplicatus, fitigle tertian with two parox¬ yfms on the regular day of attack. £. Quartanus duplex, or double quartan. £. Quartanus triplex, or ftngle quartan with regularly- returning paroxyfms, each of the intervening days being marked with a /lighter attack. n . Quartanus duplicatus, or Angle quartan with two paroxyfms on the regular day of attack. 0. Quartanus triplicatus, or lingle quartan with three paroxyfms on the regular day. Genus III. Epanetus, [from I remit.] Re¬ mittent fever. Generic characters — Strikingly exacer¬ bating, and remitting, but without intermiftion ; one pa¬ roxyfm every twenty-four hours. It is quite unneceSary to defcribe minutely the fymp- toms of the remittent fever, after the ample detail which we have given of thofe of fever in general. We may juft obferve, however, that it varies extremely in its cha- rafter, according to the feafon, climate, and other cir- cumftances under which it appears. In its milder forms, the remittent begins with chillinefs, laflitude, pains in the bones, head-ache, and a difordered condition of the ftomach, lofs of appetite, ficknefs, and even vomiting. At night the febrile lymptoms run high ; the heat and thirft are great, the tongue and mouth are parched, the pain of the head is violent, the patient is totally unable to deep, and is continually tolling and tumbling about, and often becomes delirious. But generally in the morn¬ ing, an imperfe& fweat brings on a remiftion of all the fymptoms. In the evening, the paroxyfm returns, but is not preceded by any cold fit or fhivering; yet it is commonly more fevere than the former. Next morning it remits as before; and thefe periodical changes recur daily, becoming however lefts marked, if the difeafe he negleCled, until the fever infenlibly aftumes a continued form. The pulfe is full and quick during the remifllons to indicate fever ; but rigors feldom precede the fits after the. firft attack. Many patients difcharge a bilious mat¬ ter from their ftomachs by vomiting, and all are difor- dered in that organ. The more violent form of this com¬ plaint, as exemplified in the yellow fever, has already been tlefcribed. The milder form is to be treated accor¬ ding to the fame indications as the fevere ; but, of courfe, by much lefts powerful meafures. Here we have three fpecies, with their. varieties. 1. Epanetus rnitis, the mild remittent: pulfe regular, though F A T 1 1 O though frequent; debility flight; remiffion diftinguifhed by fweating or a cloud in the urine. 3. Epanetus malignus, the malignant remittent ; pulfe /mail, hurried, irregular; debility extreme; often with flgns of putrefcency. Of this there are four varieties. а. Autumnalis, the autumnal remittent: often with a ftrong tendency to affume the tertian or double tertian type. б. Flavus, the American yellow fever. y. Ardens, the burning, remittent, the Caufus (Kauc-of) of Hippocrates. S. Afthenicus, the highly-debilitating remittent of the fouth of Spain, Gombron, Breflaw, &c. 3. Epanetus hedlica, hedlic fever: pulfe weak ; ftages of chillinefs, heat, and fweat, varioufly intermixed, and fometimes Angle ; tire cold ftage exhaufting ; exacerba¬ tion chiefly in the evening : urine with a natant furfu- raceous feparation; countenance flightly fluflied or pale, funk, fallow, flirunk, and tremulous ; debility, but not decided proftration of ftrength ; tongue whitifli ; ema¬ ciation great, but not fudden ; vertigo, or pain in the head ; pofition often fupine ; anorexia, fometimes naufea and diarrhoea. Some writers have detailed accounts of an idiopathic Febris hedlica; but we believe it will generally be found that this is merely fymptomatic of a grave attack of Dyf. pepfia, under which article it has already been mentioned. It is for the molt part found as a fymptom in tabes ; and fometimes in phthifis, chlorofis, lues, and fcirrhous dif-' eafes of various organs. Genus IV. Enecia, [from y,h uvs, perpetual.] Conti¬ nued fever. Generic charadiers — One feries of increafe and decreafe ; with a tendency to exacerbation and re¬ in iflion, for the molt part appearing twice every twenty- four hours. There are three fpecies, befldes varieties. 1. Enecia cauma, inflammatory fever; the Synoche of Sauvages and Cullen. Heat greatly increafed ; pulfe quick, hard, and ftrong; urine red ; difturbance of the mind flight. Dr. Good has four varieties. a. Plethoricum. “Produced (fays Dr. Good) by the ftimulus of violent paflions, undue mufcular exercile, or heating foods, upon a plethoric habit ; as alfo by a fup- preflion of accuftomed difcharges, as thofe of menftrua- ticn, habitual venefedtion, or perfpiration.” /3. Biliofum : produced by the ftimulus of an undue fecretion or abforption of bile into the fanguineous fyftem. 7. Pleuriticum : accompanied with a violent ftitch or pain in the pleura. S. Cephalalgicum : accompanied with great pain in the head, 2. Enecia typhus: pulfe fmall, weak, and unequal; ufually frequent ; great proftration of ftrength, and dif¬ turbance of the mental powers. Two varieties. a. Mitior, the nervous fever : with flight Ihiverings ; heavy vertiginous head-ach ; oppreflion at the praecor- dia ; naufea ; fighing; defpondency ; coma or quiet de¬ lirium ; urine whey-like. (3. Gravior, putrid fever s countenance flirunk; eyes vague, fuffufed, and with a film of mucus; tongue chap¬ ped, dry, and very fordid ; complexion brownilh or flight pink; lips tremulous, fometimes muttering 5 pofition fupine, limbs extended ; refpiration frequent and tremu¬ lous ; little increafe of heat ; bowels irregularly aftedled; relaxation of the fphindter redlum, £tc. ufual duration from fix to forty days. 3. Enecia fynochus : compounded of cauma and ty¬ phus: in its commencement refembling the former; in its progrefs the latter. Here are four varieties. d. Sudatorius : carried off by a critical fweat in an early ftage of the difeafe. (3. Flavus: with yellownefs of the fkin, attended with a lenfe of burning heat. Nearly allied to Epanetus flavus, and E. ardens, varieties of E. malignus. VOL. XIX. No. 1299. LOGY. 227 7. Puerperarum, child-bed fever. See the article Parturition, vol. xviii. p. 674. S. Soporofus: accompanied with great drowfinefs, or ftupor. Order II. Plogotica, [from (pfcyo, I fet fire to, or burn.] Inflammations. Having already (fated in what mode the primary phe¬ nomena of inflammation were induced, and that the va¬ rieties of appearance this adtion exhibits were the refult of changes in the fecernent fyftem rather than in the red- blood veflels ; we (hall now proceed to confider the latter part of the pofition in queftion, i. e. what changes the fyftem of the white veflels undergoes in order to produce the varieties of inflammation. The principal varieties inflammation exhibits on its firft occurrence, are thofe of phlegmon, eryfipelas, and a mixture of both. In each, heat, pain, rednefs, and fwelling, are apparent ; but eryfipelas differs from phlegmon in this, that, while in the latter the degree of pain, rednefs, &c. gradually decreafing, clearly indicates, that the morbid change in the properties of veflels is moll intenfe in the middle of the injured part, and that the natural adtion is gradually reffored towards its circumference ; in the former, heat, red¬ nefs, See. prefent an abrupt difcontinuance, one line having all the charadiers of inflammalion, but the next being perfectly pure from difeafe. The pain alfo is not of the fame kind, nor the fwelling fo great, in eryfipelas as in phlegmon. The remarks made while treating on inflammation in general, as to its mode of produdiion and its general ef- tedts on the conftitution, are molt particularly applicable to phlegmon. It remains, therefore, that we fliould now fpeak more particularly of eryfipelatous inflammation. From various circumftances it feems pretty clear, that eryfipelas is inflammation of the fkin ; but how it happens that the veflels of the fkin fhould differ fo materially from other parts in the phenomena they exhibit under the fame adtion, is one of the unfolved problems of our fcience ; nor, as far as we know, has its folution been ever attempted. According to Cullen, indeed, eryfipelas depends “ on a matter generated within the body, and thrown out, in confequence of fever, upon the furface of the body.” Mr. Pearfon reprefents it as the “ critical termination of another difeafe, fuch as obftrudted men- ftruation, quartan ague, fuppreffed fuppuration, fpa Ano¬ dic and convulfive difeafes.” But thefe are merely vague conjedtures as to remote caufes, and have nothing to do with the queftion, why does inflammation in the cuta¬ neous ftrudture exhibit irregularity of fwelling, and burn¬ ing pain, &c. and why does inflammation in other parts manifeft the phenomena of phlegmon ? If it be faid, that this depends on the peculiar ftrudlure of the fkin, we mull fhow that thofe authors have been deceived who have fpoken of phlegmon attacking the fkin, and of ery¬ fipelas attacking deep-feated parts. It is a remarkable fadt, that thofe authors who have endeavoured to explain the phenomena of inflammation have for the raoft part confined their attention to phlegmon. It does not ac¬ cord wdth the purpofe of the prefent effay to fpeculate on this difficult lubjedt ; but we (hall juft lay the fadts before our readers, whence they may draw their own concluiions. In the firft place, if eryfipelas be not folely confined to the fkin, it is in this ftrudlure that it is moft frequently met with, and moft fuddenly, extenfively, and clearly, manifefted. It is much influenced by and dependent on the Hate of the nervous fyftem, and of the primee vice, at¬ tacking for the moft part intemperate livers; and, when it attacks that part of the fkin in which the nervous fyf- tem is moft acute, it is developed with aflonifhing force and celerity. It is liable to be connedled with phlegmon, in which cafe we fhould fuppofe phlegmon to be the af- fedlion of deep-feated eryfipelas of the fuperficial parts of the body. It is intimately connedled with the ftate of 3 N the 228 PATHOLOGY, thefecernent veflels; and one peculiar connexion between eryfipelas and thofe veflels is (hown in what is called cedematous eryfipelas. It is alfo connedted with a vaft majority of that difeafed action of the fecernents which are called cutaneous difeafes. It is unattended with the throbbing which is experienced in the arteries of phleg¬ monous limbs. The following charadteriltics may be alfo added. When eryfipelas is of an unmixed kind, it has not the dark red colour which common inflammations have, but a lighter red, with a yellow tinge, which is par¬ ticularly obfervable towards the termination of the dis¬ order. The fwelling which occurs is unattended with any remarkable induration, and forms a very inconsider¬ able prominence. The Ikin of the inflamed part has a Shining appearance, and, on being touched with the finger, turns white at the fpot where the preffure is made ; but the bright red colour immediately afterwards returns. The pain is ufually of a burning Shooting defcription ; and the patient frequently complains of a fort of itching, which is found to be particularly annoying. The fwelling, which happens in cafes of eryfipelas, is not only lefs hard and elevated than that of phlegmonous inflammation, but it is, at the fame time, quite irregular. Another re¬ markable feature of eryfipelas, is the manner in which this inflammation often changes its Situation, by getting well on one fide, while it is Spreading in fome other di- redtion. The alteration which the Skin undergoes in eryfipelas confifts in its feeling at the part affedted lefs pliable than in the natural State, and a little thickened. It will be recolledted that we have objedted to all fur¬ ther divifion of inflammation than this, into phlegmo¬ nous and eryfipelatous ; but many divifions have been founded on the terminations of inflammation. Thefe we confider as dependent on the adtion of Secreting vef- iels; and the latter adtion dependent on the plethoric Slate of the blood-veffels in inflammation, and the altered condition of their own nerves. We proceed therefore to Speak of the terminations of inflammation. The firfi: termination is that in which, the capillaries recovering their powers, and the nerves lofing their in- creafed fenfibility, the phenomena of inflammation ceafes to exift, and the natural functions of the parts affedted continue. This is the molt favourable event that can happen; but, according to Dr. Parry, the leaft: frequent. This is true of phlegmon, but by no means of eryfipelas. Even in phlegmon, refolution often takes place before the fwelling of the injured part has come on. ^ Now as to the connexion between inflammation and its products, it is to be noted, that the latter are pro¬ duced in two ways : firft, by Simple increafe of alteration in the adtion of the fecernents, as in extravafation of fluids on the nervous and ferous membranes; the Se¬ cond, by the abfolute acceflion of new properties in fome of the inflamed veffels, or, by the adtual growth of new veSTels, as in adhefion, fuppuration, and ulceration. It was a favourite opinion of the late John Hunter, and one which has been very generally adopted, that not only inflammation, but each of the above-mentioned terminations, w'ere instituted for the determinate purpofe of curing difeafe; that, if the powers of a part were not competent to produce one adtion, they Set up another, which required lefs power, and which might attain the objedt in view, though more Slowly and lefs efficiently. There is Something hypothetical in all this ; yet whoever attentively considers the reparative procefles of the body, cannot fail to conclude, that the laws to which they are fubjedted are framed in fuch a manner that their opera¬ tion tends under ordinary circumstances to the fanity of our frame. As, however, the immediate agents con¬ cerned in their laws can have no choice of adtion or adaptation of means to ends ; as they cannot vary with uncommon circumstances ; fo we frequently witnefs from their operation baneful effedts ; and hence it be¬ comes our province to control their operations under many circumstances, though upon the whole we muft view them among the molt beautiful phenomena which the animal economy prefents. The firft divifion of the produdts of inflammation em¬ braces the hiftory of thofe arising from the Simple increafe of, and alteration in, the adtion of fecernent veSTels. It is obvious that thefe produdts of inflammation can only, be manifested in particular ftrudtures. Various divifions of thefe ftrudtures have been made by Bichat ; but it is pretty generally allowed, that the divifions of membra¬ nous parts made by this author are too minute. The production of the firft terminations of inflammation re¬ quires the prefence of an apparatus furnished with exha- lants or fecretory veflels from the arterial or capillary fyftem of the refpedtive parts. This apparatus confifts. either of fome Ample furface, as the lkin and various parts of the mucous membrane ; of fome natural cavity, the internal furface of which is lined with Similar membrane as the Stomach, bowels, bladder, &c. or of lome difconti- nuity of fubftance, forming a virtual, though often not a real, cavity ; into which either exhalants open imme¬ diately, as in the cellular fyftem; or which is lined with membrane, capable, by means of Similar exhalants, of furnishing its appropriate fluid, as the ventricles of the brain, medulla oblongata, and nerves; the intervals be¬ tween the coverings or Sheaths of the fame parts, the duplicatures of the pleura and peritonaeum, the pericar¬ dium, the fynovial receptacles, & c. Or, laftly, this appa¬ ratus confifts of fome excretory dudt or dudls communi¬ cating with the part, if glandular, as in the mamma;, liver, kidneys, falivary glands, &c. in which cafes the duel anfwers the double purpofe of providing during health a falutary fluid, and of evacuating the part, when affedted with exceffive momentum of blood. It is obfervable alfo, that the feveral organs fo fupplied have, ufually, the combination of two of thefe circum¬ stances of Structure, fo as to acquire a double power of evacuation, either immediately from themfelves, or from neighbouring portions of the fame arterial branches. Thus the lungs have pleura without, and mucous mem¬ brane within ; the liver, peritonaeum without, and pori biliarii from within, &c. To thefe may be added the cel¬ lular, parenchymatous, and other, fubitances, forming a proportion of the mafs of various parts, and affording a third emundtory for the fuperfluous contents of blood- vefiels, by means of exhalants and fecretory capillaries, every where opening into them, as through the mem¬ branes before defcribed. This is the cafe in the medulla of the brain, and in various other organs ; in which we often find exhaled fluids, as well as between the mem¬ branes and in the ventricles of the former, and on the feveral furfaces of the latter. The nature of the fluids effufed in inflammation, and their effedts on the feveral parts, vary confiderably, ac¬ cording to the nature of the texture from which they originate, and to the degree of the malady which gives them birth. From each of thefe ftrudtures fimilar produdts are derived. In all of them the firft operation of inflamma¬ tion is generally to increafe the natural fecretions. Hence mucus is more copioufly fecreted in the alimentary and pulmonary expanfions of the mucous membrane, in the uterus, and in the vagina. Serum is copioufly effufed in the cellular tiflue, on the ferous membranes ; and the Se¬ cretion of tears is increafed from the eyes, &c. As the inflammation advances, or as it is more intenfe, the pro¬ dudts vary: the mucous membrane pours forth coagu¬ lating ferum, fibrine, pus, or blood ; and the ferous mem¬ brane fimilar produdts. Neither chemical analyfis nor the known properties of thefe fubftances allow us to in¬ fer any material difference in them, whether they arife from the ferous or mucous membranes. All thofe parts which are fecreting furfaces, and at the fame time have outlets, as the mucous membranes, are not commonly fubjedt to that procefs called adhefion. ; for the PATH the natural fecretions of the part a£t perpetually fo as to throw off the firmer accumulations, and to evacuate them from the body: while, on the other hand, increafed fe- cretion on the ferous furfaces, when it becomes indurat¬ ed, agglutinates the correfponding parts together, be¬ comes organized, and thus are adhefions contracted. It is 1 y this procefs occurring in artificial cavities, as wounds, &c. that reparation takes place. The fame procefs may be confidered as the origin of that cream-like fubftance depofited in the cavities of joints, in capfular ligaments, in the (heaths of tendons, See. which, by the abforption of the thinner parts, becomes what is called chalk-Jlune, a well-known effect of highly-inflammatory gout, and con¬ fiding of urat of foda. The fame is depofited in the cel¬ lular fpace between the inner and fibrous coats of the larger arteries, becoming true bone, or phofphate of lime, and producing fuch diftreffing effeCfs, refulting, according to fome late obfervations, from an inflammatory affeCtion of the va.fa vaforum 5 and when on the coronary arteries of the heart, according to Parry, the proximate caufe of fyncope angens. Though thefe various products are for the moft part the refult of inflammation, yet it is by no means clear that they are not fometimes prefent without the occur¬ rence of this action. Copious mucous excretions are often habitual to old perfons in whom we cannot infer increafed vafcular a&ion ; and the various depofitions of the fcrofulous diathefis feem generally to be caufes rather than confequences of inflammation. On the other hand, as increafed fecretion may exift without inflamma¬ tion, fo the latter may occur without the former; nor does the peculiar modification which gives rife to this circumftance feem clearly afeertained. It would feem indeed, that the violence of the inflammation had fome influence over the fufpenfion of fecretion ; but this does not uniformly happen, fince the violent inflammation we have mentioned as incidental to fevers of hot climates are often accompanied from the firft with copious though morbid fecretion. In the generality of cafes, however, in which fecretion is flopped, we believe it will be found, that the capillary fyftem is lefs fuperficially and more violently inflamed than when this aftion is increafed. It is alfo to be noted, that on fome occafions increafed fecretion brings on inflammation, though by no means fo frequently as inflammation induces fecretion. In thefe cafes we obferve flight and unimportant exceffes in the fecreting powers, after having continued fome time, fuddenly exhibit the regular phenomena of inflammation. When inflammation terminates by the procefles of ad- hefion, fuppuration, or ulceration, we infer, that either new fecreting veflels are formed, or that the fanguineous capillaries acquire the fecreting faculty. Of adhefion we have before fpoken. It is generally allowed to be produced by the formation of new veflels. We infer that fuppuration and ulceration are procefles which depend on the capillaries acquiring new faculties, becaufe there is in each a lofs of fubftance which could only be thus ac¬ counted for. The capillaries having acquired the above- mentioned property, and loft that of tranfmitting blood to the affe&ed ftrufture, muftdiminifti from the deficiency of fanguineous fupply, abforption being l'uppofed to con¬ tinue. Moreover, pus, the fluid fecreted, is, according to recent experiments, but (lightly removed in its nature from the blood itfelf. Hence it would naturally be the production of veflels which poflefled the fecreting power in the lead perfeft manner. We infer it alfo from the fuppofed inadequacy of the common fecernents of thofe parts in which fuppuration is often eftabliflied to pour forth fuch copious fupplies of pus ; and laftly we infer it, becaufe how, other wife than on the fuppofition that a change takes place in the terminations. of the capillaries, could we explain the fad, that healthy ulcers do not bleed ? The laft and moft fatal termination of inflammation is gangrene. This alfo exhibits fomewhat different appear- O L O G Y. 220 ances, as it affefts the bones or flefli, or as it is produced from the furface of an ulcer, in which latter cafe the gangrened portion is called a Jlcrugh. Gangrene is termed the death of a part; and is generally fuppofed to be the aftual abolition of all vital powers and motions, and that the part actually returns to inert matter. The fad that gangrened parts look different from dead parts is readily explained by the fuppofition, that the former have entirely loft their contractility and elafticity, while the latter, as is u'ell known, do not lofe the firft pro¬ perty for fome hours, nor the fecond for fome days, after what is commonly called death. See Gangrene in this article. The natural connexions of philofophy would lead us in this place to an examination and hiftory of local inju¬ ries followed by inflammation and the conftitutional or febrile difturbances arifing therefrom. As however the arbitrary difeafes of Medicine and Surgery have feparated the practical application of thefe rules, we inultdefer thefe fubjeCts till we arrive at the article Surgery. To that article we (hall alfo refer the reader for an account of external injuries, or fuch as belong to manual treatment. It may not be amifs, however, to obferve, that the fe¬ brile (late which fupervenes on local injury does not dif¬ fer from common fever, except that, being kept up by a certain irritating caufe, it can only be cured by the re¬ moval of fuch caufe; and hence that all treatment muff: be direCled to the cure of the local difeafe. And farther, as the local injuries are intenfe, or the conftitution mor¬ bid, the fever will affume inflammatory or heflic charac¬ ter, or a mixture of both. This Order contains eleven Genera. To explain Dr. Good’s arrangement of Inflammation, we (hall copy part of a note fubjoined to this order. He therein remarks, that “ The whole of the obfervations of Mr. John Hunter upon this fubjeft are worthy of being deeply ftudied; and will not a little elucidate the nature of the arrangement introduced into the prefent method. It may be fuffi- cient to obferve, that in treating on inflammation, he di¬ vides the body into two parts : 1, the circumfcribed ca¬ vities, organs, and cellular membrane which connects them ; and 2, the outlets of the body, commonly called mucous membranes, as the dufls of the glands, alimentary canal, & c. He diftributes inflammatory affections into three kinds, ad'hefive, fuppurative, and ulcerative. Ad- hefive inflammation belongs chiefly to the former of the above two parts of the body, where they are deeply feated; and appears intended to take place in order to prevent fuppuration. It applies therefore peculiarly to the ge¬ nus Emprefma in the prefent order, except in gaftritis, enteritis, and cyftifis; in all which, however, we fre¬ quently meet with ftriking examples of the adhefive in¬ flammation, or true Emprefma ; infomuch that the af- fefted organ becomes at times fo clofely united with fome adjoining membrane or other organ, as to obtain a kind of artificial wall, or paries, and prevent the efcape of its contents into another cavity, when ulcerated through the whole thicknefs of its fubftance. Suppura¬ tive inflammation belongs chiefly to the famedivifion of parts, placed near the furface ; and confequently applies peculiarly to the two genera of Phlegmone and Phyma. The ulcerative belongs chiefly to the fecond order of parts, as the mucous membranes and outlets ; and hence principally applies to the genus Erythema, as it muff alfo be allowed to do to that of Phlyfis. Deep-feated fuppurative inflammations and abfeefles cannot well be placed in either of thefe genera ; and have a claim to be confidered by themfelves ; they are hence included in the genus Apoftema, with which the order opens. Genus I. Apojlema, [ctnoftb ipu, to recede from.] Deep- feated abfeefs. Generic charadlers — Large fuppurative inflammation in a deep-feated organ; pus copious and confined. This genus contains five fpecies. 1. Apoftema commune, or fimple abfeefs: inflamma¬ tion PATHOLOGY. 230 tion common to the fiefhy parts; pain obtufe; tumour fpreading externally; tender to the touch; pus laud¬ able ; readily incarning when opened. See Surgery. 2. Apodema pfoaticum, pfoas abfcefs: pain and tenfion about the loins, (hooting down the (pine and thigh; dif¬ ficulty of (landing ereft ; fiudluating enlargement along the pfoas tnufcle; apex of the tumour immediately be¬ low the groin. See Surgery. 3. Apoftema hepaticum, abfcefs of the liver: diffufe pulfating tumour in the region of the liver ; preceded by pain, a yellow countenance, and fhiverings. This is by no means a common complaint in this country; but it is met with in hot climates, where in¬ deed the medical practitioners are faid to be remarkably expert in performing an external operation for its relief. We fhould take efpecial care to prevent fuppuration from happening in this important organ, by aftive treatment during the inflammatory period of the complaint. Sup¬ puration is prognofticated if inflammation continues in the liver feveral days ; if the pain remits, and is followed by a pulfation in the fame place, and if fhiverings come on, with a countenance of a yellowifh colour ; foon after which a tumour and a fenfe of weight are perceived in the region of the liver: a heftic fever follows, with third, and extreme feeblenefs. Aretasus obferves, that pain generally extends to the throat, and to the extremity of the (houlder ; and a dry, but not very frequent, cough afflidls the patient. He further remarks, that this dif- order is fotnetimes miflaken fora tumour of the perito¬ naeum ; but that the latter is more irregular, and is not circumfcribed by the limits of the hypochondrium. The favourable termination of this complaint depends on the manner in which the abfcefs burfls. If externally, we may entertain fome hope ; if internally, at the cavity of the abdomen, it is for the mod part fatal. See Hepa¬ titis. 4. Apodema empyema, lodgment of matter in the ched: fixed pain in the chefl ; breathing laborious, but eafiell in an ereft pofition ; difficult decumbiture on the found fide ; fiudluating enlargement on the fide ad'edled; dry tickling cough. It is often brought on by difeafed adlion in the pleura without ulceration. There is reafon for believing that matter is contained in the cavity of the chefl, when, after a pleurify, or inflammation in the thorax, the patient has a difficulty of breathing, parti¬ cularly on lying on the fide oppofite the affedted one ; and when an cedematous fwelling is externally percep¬ tible. The malady is fometimes relieved by the opera¬ tion of paracentefis thoracis, (fee Surgery;) and cafes are related in which the matter is faid to have been ab- lorbed. 5. Apodema vomica: deranged fundlion of a thoracic or abdominal organ, fucceeded by copious difchargeof pus into fome part of the alimentary channel, and its evacu¬ ation by the mouth or anus. The term is here ufed in the large fenfe in which it is employed by Celfus, who applies it to a burding of pus from the liver, or any other large internal organ, as well as from the lungs. “ Si vero jecur vomica laborat, eadem facienda funt, quse in ca^teris interioribus fuppurationi- bus.” Lib. iv. cap. 8. Sauvages follows him in this in¬ terpretation. Boerhaave and Cullen confine vomica to the lungs, and that in a more reftrained fenfe than mod writers ; for they limit it to what has been called, though with no great accuracy, occult vomicae (vomica clauja). Linnteus and Vogel, on the contrary, while they confine the term to the lungs, explain it by open vomicae ( vo¬ mica aperta ), in which the pus is thrown forth profufely and fuddenly Genus II. Plilegmone, [from (pXiyu, to inflame.] Phleg¬ mon ; abfcefs or tumour near the furface. Generic cha- raflers — Suppurative fubcutaneous tumour ; tenfive; glabrous ; painful ; at length fiudluating, and burding fpontaneoufly ; the pus uniform and mature. + The treatment of phlegmon is to be conducted, as far as local treatment is regarded, by topical applications, which are generally either cold or warm lotions. Heat is well known to promote and increafe all animal aflions, and mud therefore tend to keep up and augment the procefs of inflammation. Hence arifes the indication to diminifh the heat of the part affedled, by making ufe of cold topical applications, and maintaining a continual evaporation from the inflamed furface. The common plan is to dip linen in the faturnine lotion, and, after folding it once or twice, lay it all over the part affedted, taking care afterwards to keep it condantly wet with the application. In mod indances cold water will anfwer every purpofe ; in others the aqua ammonias acetatx, or lotions of the fulphateof zinc, alum, &c. may be employ¬ ed. Poultices made with linfeed-meal and water, or with bread and water, are the ordinary applications of this kind ; and fo great is the importance which ought to be attached to the circumdance of making them foft and unirritating, that a furgeon of the firfl eminence has not difdained to make their compofition the fubjedt of partof a ledture before the College of Surgeons. With poultices, fomentations are alfo frequently proper, as having in all fevere cafes a great effedl in leflening the pain. Like- wife, when fuppuration is unavoidable, they accelerate the cure by promoting the formation of matter, and hadening its approach to the furface of the body. The common method is to dip flannels in a decodlion of chamomile-flowers, or white poppy heads, wring them, and apply them very warm to the inflamed part ; but warm water anfwers the purpofe as well. In difcriminat- ing the cafes which require cold applications from others to which warm ones are mod ferviceable, the pradlitioner fhould always bear in mind, that, when fuppuration is inevitable, it is invariably mod advantageous to difcon- tinue cold allringents without delay. In general where the chance of the phlegmon being refolved is great, cold applications are bed ; but for the mod part the choice of the topical remedies mud be regulated by the patient’s feelings. There are fome patients who feem to derive mod eafe from hot applications ; there are others who appear to experience mod comfort from cold ones. The latter remedies ought perhaps rather to have the prefe¬ rence, when the profpedl of preventing fuppuration is fair and rational, and when at the fame time they afford as much eafe as poultices. There are feven fpecies. 1. Phlegmon communis : tumour common to the fur¬ face ; bright-red; hard; defined; hemifpherical ; pola¬ rized ; gradually foftening and burding at the pole. 2. Plilegmone parulis, gum-boil : tumour feated on the gums; deep red ; liardifh ; undefined; pain obtufe. Divided into two varieties. as. Simplex : limited to the fubflance of the gums. (2. Cariofa : connedled with a caries of a tooth or focket. When the former variety happens, the part may be freely opened with the lancet, and the gum fomented. When the latter variety comes on, the offending tooth mull be drawn. 3. Plilegmone auris, impoflhumein the head : tumour feated within the ear ; pain acute, throbbing; heat and rednefs fpreading externally ; hearing diftreffingly keen, or dunned with imaginary founds; abfcefs burding with the fenfe of a loud fnap or explofion. In this complaint we fhould iyringe the infide of the ear with foap and wa¬ ter, and apply a blifter behind it. A roafled onion, though an anile prefcription, will alfo be found ufeful: it is ap¬ plied in the helix of the ear as a poultice. 4. Phlegmon parotidea, phlegmon of the parotids : tumour feated under the ear: reddifli ; hard; pain ob¬ tufe; fuppuration flow and difficult. Two varieties. a. Benigna : incarnation and cicatrization regular and obflrudled. |3. Maligna : pus illaudable, profufe, protradled ; fuc¬ ceeded by foul Houghs. Dr. Parr gives the following account of this fecond variety. The malignant parotid (wells J cs / / o '//// '//. > ofm Zngrav&t./cr die. EruJ/dap ouka. Zondmjtns is. stizs.. PATHOLOGY. Plate 1 . PATHOLOGY. 23L fwells like the milder kind, and is at firft fcarcely diftin- guilhable from it, but by its attacking in advanced life, and in females about the periodical change. It is not painful, and advances flowly to fuppuration. If the latter can be prevented by leeches, cooling applications, & c. the inconvenience, for many years, is not confider- able; but, when it fuppurates, the pus is feldom lauda¬ ble, and the patient loon finks from the difcharge. In this cafe, bark, hemlock, and the whole tribe of poifons, have been tried in vain. The wound enlarges, the Houghs become deeper, till the conftitution is completely under¬ mined, and gradually finks. The fcirrhous parotids may be extirpated, (though this is one of the mod difficult operations in furgery;) but the malignant fink deeper, and will not admit of the operation, which is always dangerous from the numerous large veffels in the neigh¬ bourhood. 5. Phlegmone mammae, abfcefs of the breaft : tumour feated in the breaft; pale-red; hardilh; in irregular clufters; pain pricking and acute; fuppuration quick and copious. Here alio we have two varieties. a. Violens : from fevere prefl'ure or blow. (3. La&antium, milk-abfcefs : from redundancy of milk. Both varieties are charafterifed by tumefaction, tenfion, heat, rednefs, and pain ; fometimes in both breafts, but molt commonly in one. Pyrexia generally attends the difeafe. It is fometimes very quickly formed, and in general without any thing preceding to Ihow it; but now and then a flight Ihivering is the forerunner. This difeafe terminates either in refolution or fuppura¬ tion. If left to itfelf, it generally terminates in i'uppu- ration. But it is often of long continuance; it is very painful, but feldom fatal, unlefs when abfolutely neg¬ lected. The termination of the difeale by gangrene is feldom to be apprehended ; at leaft few, if any', have feen the difeafe terminate in this way. As to the firft variety, during the inflammatory ftage, cold lotions, purging, See. may be had recourfe to. In the fuppurating ftage, the fame treatment is required as in the var. (3, or milk-abfcefs. This latter may in ge¬ neral be prevented by an immediate application of the infant to the breafts after delivery, or at leaft before they are turgid with milk. When pus is actually formed, a foft warm poultice, compofed of bread and water, or of a decoCtion of poppies and linfeed meal, ftiould be con- ftantly kept upon the part, and renewed every three or four hours; at the fame time carefully fufpending the enlarged breaft, with an handkerchief fpread under it, and tied behind the neck. It is very rarely proper to make any artificial opening in thefe abfeeffes : they ftiould be permitted to burft of themfelves, and be poulticed as long as the hardnefs or inflammation continues. During this painful period, the child muft be fuckled by the healthy breaft; for it rarely happens that the milk is pure during a ftate of inflammation, or that the mother can bear her child’s attempt to draw the nipple. During the fuppurating procefs, the dietetic regulations laid down under Dyfpepfia muft be rigoroufly enforced. The local application muft vary with the appearance of the ulcer when it heals ; and the adminiftration of remedies will alfo be regulated by the fame criterion. See Parturition, vpl. xviii. p. 71a, 13. 6. Phlegmone bubo : tumour feated in a conglobate gland ; reddifii ; hard ; diffufe ; not eafily fuppurating ; opening with a callous edge. Divided into, a. Simplex : unconnected with any conftitutional or foreign poifon. |3. Virulentus : produced by fpecific virus, or con¬ nected with conftitutional affeCtion. The glands moltly infeCted are thofe of the inguen and axilla. This laft va¬ riety is found chiefly in lues and peftis. Often cured by vomits after fuppuration has advanced. The firft variety will require the fame treatment dur¬ ing its inflammatory ftage as phlegmon in other parts, and the fame during the fuppurating ftage as common Yol. XIX. No. 1299. abfcefs. The fecond variety, being fymptomatic of other difeafes, will properly be treated under thofe heads. 7. Phlegmone .phimotica, phimofis and paraphimofis : tumour feated in the prepuce; diffufe; obtufely pain¬ ful; imprifoning the glans, or ftrangling it by retraCfion. a. Tncarcerans: the prepuce protraCfed, and imprifon¬ ing the glans. Numerous fubjeCls are born with a con¬ traction of the aperture of the prepuce; and the cafe is then called a natural or congenital phimofis. Sometimes, in adults, and particularly in old perfons, the prepuce contracts fo much, without any evident caufe, that its cavity becomes filled with urine during the aCt of mak¬ ing water, and great pain is the confequence. In cafes where the opening is exceedingly fmall, and the diforder is either congenital, or has occurred without obvious in¬ flammation, it is by no means an uncommon circum- ftance for calculi to be formed under the prepi ce. Thefe fometimes refemble in fliape the glans, on which, as it were, they are moulded. When the phymofis is congenital, and has exifted a long while, it frequently happens that, in confequence of inflammation, adhelions have taken place between the glans and the prepuce; and, in this event, it may not always be in the power of the furgeon to effeCt a cure. The poflibility of doing fo muft depend, in a great meafure, upon the extent and firmnefs of the adhelions. According to Richerand, it is feldom practicable to deftroy them after the patient has attained the age of puberty. No operation ought to be praCtifed on children for the natural phimofis, unlefs prefling inconvenience ftiould immediately arife from the malformation. The conftric- tion generally goes off, as fuch fubje&s approach the adult ftate. For the mode of performing the operation when neceffary, fee Surgery. For the treatment of the difeafe, and alfo the other variety, (3, ftrangulans, or paraphimofisy in which the prepuce is retraCled and ftrangling the glans, fee Lues of this article. Genus III. Phyma, [Gr. a tubercle, from (pvu , to break or gulh out.] Boil, carbuncle, &c. Generic cha¬ racters — ImperfeClly-fuppurative, cutaneous or fubcu- taneous tumour ; the abfcefs thickened, and indurated at the edge; often with a core in the middle. There are fourfpecies, though Dr. Good has numbered them as if one were omitted. 1. Phyma hordeolum, the ftye : tumour feated in the verge of the eye-lid; granular, hard, reddifli, fore to the touch ; fuppuration confined to the point. This is generally produced by indigeftion. Ple.nck affirms that he knew' a man who uniformly had a ftye after drinking ardent fpirit. He points out the following refemblance between a ftye and a boil : “ Eft tuberculum inflamma- torium, parvo furunculo Jimile,m margine palpebrarum.” See Surgery. 2. Phyma farunculus, the boil: tumour common to the furface ; deep-red ; hard, circumfcribed, acutely tender to the touch ; fuppurating with a central core. See Surgery. 3. Phyma fycofis : tumour excrefcent, flelhy, fig- fliaped, darkifh-red, fprouting from the hairy part of the head or face; gregarious; often coalefcing; difcharge partial and fanious. Dr- Bateman has deferibed the Sycofis to confift of “ an eruption of inflamed but not very hard tubercles, oc¬ curring on the- bearded portion of the face and on the fcalp, in adults, and ufually cluftering together in irre¬ gular patches.” Some difference takes place in the ap¬ pearance and progrefs of the eruption, when it is feated in the chin and in the fcalp. Hence it is divided into two varieties. ce. Sycofis barbae, (S. menti, Bateman.) The turnout- hard, roundifti, pea-lized ; feated in the beard; com¬ monly in clufters ; occafionally confluent, and fpreading from ear to ear ; difcharge fmall and gelatinous, beard matted. See Plate I. fig. 1. 3 & According 232 PATH G According to Dr. Bateman, in this complaint the tu¬ bercles arife firft on the under-lip, or on the prominent part of the chin, in an irregularly-circular clutter ; but this is fpeedily followed by other clutters, and by diftimft tubercles, which appear in fucceflion along the lower part of the cheeks up to the ears, and under the jaw to¬ wards the neck, as far as the beard grows. The tuber¬ cles are red and finooth, and of a conoidal form, and nearly equal to a pea in magnitude. Many of them con¬ tinue in this condition for three or four weeks, or even longer, having attained their full fize in feven or eight days; but others fuppurate very tlowly and partially, discharging a fmall quantity of thick matter, by which the hairs of the beard are matted together, fo that (ha¬ ving becomes impracticable from the tender and irregu¬ lar furface of the (kin. This condition of the face, ren¬ dered rugged by tubercles from both ears round to the point of the chin, together with the partial ulceration, and (cabbing, and the matting together of the unfhaven beard, occafions a confiderable degree of deformity; and it is accompanied alfo with a very troublefome itching. - Though this complaint occurs, of courfe, chiefly in men, women are not altogether exempt from it. But in them it is commonly flight, fince it is not expofed to the lame irritation as when it occurs in the male fex. Its duration is very uncertain ; being fometimes removed in a fortnight; fometimes the fuppuration goes on for many weeks ; and fometimes the fuppurating tubercles heal, and again begin to difcharge. Occafionally the dif- eafe difappears for a feafon, and then recurs. 6. Sycoiis capilli, (S. capillitii, Bateman.) Tumour foft, unequal, cluttering : (bated in and about the hair of the head ; difcharge ichorous, copious, and fetid, from a fungous furface. See Plate I. fig. a. The Sycofis capilli is feated chiefly about the margin of the hairy fcalp, in the occiput, or round the fore¬ head, and temples, and near the external ear, which is alfo liable to be included in the eruption. The tuber¬ cles rife in cl niters, which aft'ebt the circular form; they are fofter, and more acuminated, than thofe on the chin ; and they all pafs into fuppuration in the courfe of eight orten days, becoming confluent, and producing an ele¬ vated, unequal, ulcerated furface, which often appears granulated, fo as to afford fome refemblance to the in¬ ternal pulp of a fig. The ulceration, as Celfus dates, is generally humid ; for there is a confiderable discharge of a thin ichorous fluid, which emits an unpleafant rancid odour. Dr. Bateman informs us that “the Sycofis, under its firfl-mentioned form, may be diftinguifhed from Acne indurata, by its feat being exclufively on the bearded part of the face; by the fofter, more numerous, and cluftered, tubercles ; and by the ulceration which they tend to produce. And, under its fecond form, in which it is fomewhat affimilated to the eruption of favous puf- tules, or Porrigo favofa, affecting the face and the bor¬ ders of the capillitium, it may be difcriminated by the tuberculated and elevated bate of the fuppurating tu¬ mours ; not to mention the adult age of the patient, and the abfence of contagion.” As to the treatment of Sycofis, when the tubercles are numerous, inflamed, and confluent, and efpecially w hen the fuppuration is either beginning or confiderably ad¬ vanced, the molt fpeedy benefit is derived from the ap¬ plication of poultices, at night, of linfeed powder, bread and milk, or other Ample ingredients. In the lefs fevere forms, warm ablutions or fomentations may be fubftituted. When the inflammatory fymptoms are reduced, and in cafes where they are from the firft mo¬ derate, the healing procefs is much promoted, and the difcharge moderated and reftrained, by the application of the unguentum hydrargyri nitrati, diluted with three or four parts of Ample ointment, or by the ung. hydrarg. prascipitat. united with an equal portion of the zinc LOGY. ointment, or the cerate of acetate of lead. At the fame time it is ufeful to prefcribe antimonials, with alterative dofes of mercury, followed by cinchona, or ferpentarJa, and the fixed alkalis ; or fuch other meafures as may be required to re-eftablilh the functions of the chylopoietic vifcera, which arealmoft always difordered in Sycofis. 4. Phyma anthrax, (Erythema anthrax, Cullen.) Car¬ buncle: tumour common to the furface; flat; firm; burning ; penetrant ; livid and veficular; orcrufty above, with a fordid and gangrenous core below; imperfectly fuppurative. There are two varieties. a. Pruna, the efcar carbuncle: cruft black; oozing an erofive ichor,, or fanies. Q. Terminthus, the berry or fungus carbuncle. See the article Surgery. Genus IV. Ionthus, [Gr. a violet or purple eruption ; from ion, purple; or from onSo?, filth.] Tubercles in the face. Generic characters — Unfuppurative tubercular tumour; ftationary, and chiefly common to the face. This genus (the Acne of Dr. Bateman) is charaCter- ifed by an eruption of diftinCt, hard, inflamed, tubercles, which are fometimes permanent for a confiderable length of time, and fometimes fuppurate very llowly and par¬ tially. They ufually appear on the face, efpecially on the forehead, temples, and chin, and fometimes alfo on the neck, (houlders, and upper part of the breaft ; but never defcend to the lower parts of the trunk, or to the extremities. As the progrefs of each tubercle is (low, and they appear in fucceflion, they are generally feen at the fame time in the various ftages of growth and de¬ cline; and, in the more violent cafes, are intermixed likewife with the marks or veftiges of thofe which have fubfided. There are two fpecies. 1. Ionthus varus, the ftone-pock : red, hard, pimply, diftinCt, gregarious ; fore to the touch ; fometimes oozing a little fluid at the tip. This fpecies has two varieties. a. Simplex, (Acne indurata, Bateman.) Broad-bafedj bright red, and folid. This variety is defcribed as an eruption of fmall tubercles, which appear fingly, and are not very numerous, nor accompanied by much inflam¬ mation, nor by any intermediate affeCtion of the (kin. When it has continued fome time indeed, a little rough- nefs of the face is produced, where the larger tubercles have difappeared, in confequence of a flight cracking or difpofition to exfoliate in the new cuticle; but thefe marks are not permanent. Many of the tubercles do not proceed to fuppuration ; but gradually rife, become mo¬ derately inflamed, and again ilowly fubfide in the courfe of eight or ten days, leaving a tranfient purplifh-red mark behind. But others go on to a partial fuppuration, the whole procefs of which occupies from a fortnight to three wreeks. The tubercles are firft felt in the (kin, like a fmall hard feed, about the fize of a pin’s head, and en¬ large for three or four days, when they begin to inflame : about the fixth or feventh day they attain their greateft magnitude, and are then prominent, red, finooth, and (liining, and hard and painful to the touch. After two or three days more, a final 1 fpeck of yellow matter ap¬ pears on the apices of fome of the tubercles; and, when thefe afterwards break, a thinner humour is fecreted, which foon dries into a yellowifli fcab. The inflamma¬ tion now gradually declines, the fize and hardnefs of the tubercles diminifti, and the fmall fcab becomes loofened at the edges, and at length falls oft’ about the third week. The individual tubercles, which rife and fuppurate in fucceflion, pafs through a fimilar courfe. This eruption recurs frequently, at fliort intervals, in fome individuals, who have it partially; but in others, who are ftrongly predifpofed to it, it is more ex- ten five, and never Wholly difappears, but is, at uncer¬ tain periods, more or lefs troublefome. It is generally worft after eating heartily, or drinking an unufual por¬ tion of wine, or after the occurrence of any other caufe of indigeftion ; as well as after any inordinate excitement PATHOLOGY. of the cutaneous circulation from violent exercife in hot weather or in heated rooms, efpecially when followed by a copious draught of cold liquor. This difeafe occafion- ally puts on a much fevererafpeCh In the form to which the term in dura fa is more ftriCHy applied by Bateman, hardnefs is a remarkable feature in the appearance of the tubercle, which is at the fame time more permanent, and more apt to fpread from the face to the neck and (hould- ers, than in the preceding form. The tubercles are oc- cafionally acuminated, as if tending to immediate fup- puration, being at the fame time of a bright rofeate hue : yet many of them continue in a hard and elevated ftate for a great length of time, without any difpofition to fuppurate- Others, however, pafs on very (lowly tofup- puration, the matter not being completely formed in them for feveral weeks, and then only a final 1 part of the tu¬ bercles are removed by that procefs. Sometimes two or three coalefce, forming a large irregular tubercle, which occafionally fuppurates at the feparate apices, and fome- tiines only at the largeft. In whatever mode they pro¬ ceed, their vivid hue gradually becomes more purple, or even livid ; and their tendernefs is then extreme. Slight crufts form upon the fuppurating tubercles, which after fome time fall off, leaving fmall fears furrounded by hard tumours of the fame dark red colour ; and thefe fometimes fuppurate again at uncertain periods, and fometimes (lowly fubfide and difappear, leaving a purple or livid difcoloration, and occafionally a (light depreflion, which is long in wearing off. The general treatment of this diforder will be con¬ duced on the fame principles as (light inflammatory com¬ plaints in all parts of the body, when thefe a rife from internal irritation. The mod frequent caufe of this difeafe, as the fagacious Darwin remarked, is found in deranged aCtion of the chylopoi'etic vifeera. Dr. Bateman indeed does not feem to allow this ; for he fays that the patients of this complaint often enjoy good health, and that it is generally a local difeafe. But whoever confi- ders the caufes which, according to this author’s account, aggravate varus, will have little hefitation in concluding that the fame caufes may often produce the complaint. According to the teftimony of Dr. B. himfelf, the treat¬ ment of this complaint by repellent lotions often gives rife to vicarious difeafe in other parts; an occurrence which will never happen, we believe, if, previous to the life of thofe applications, we regulate by gentle purga¬ tive and abftinent diet the ftate of the ftomach and bowels. . The local applications to be ufed are weak fti- muli of various kinds ; as lotions of water with a fmall proportion of fpirits of wine, or a few grains of oxy mu¬ riate of mercury, the ftrength of the latter being gra¬ dually increafed (to a great degree when the tubercles are indurated) as the difeafed part lofes its inflammatory character. £. Pun&atus, the maggot-pimple : tipped with a black dot, difeharging, on the preflu re of the finger, a grub¬ like concretion of mucus. In other refpe&s this is fimi- lar to the former variety. The indurated mucus may be extracted by the fingers, or by means of a fmall blunt curved forceps, and the little tumour treated as the firft variety. In Plate II. fig. i, we have given a re prefen ta- tion of Ionthus varus ; and at A are depicted a few of the black punftas which give character to the fecond va¬ riety. 2, Ionthus corymbifer, (Acne rofacea, Bateman.) Rofy drop, or whelk : confluent ; corymbofe ; rofy mot¬ tled with purple ; often disfiguring the noftrils with pen¬ dulous lobes ; irritated by cordials or expofure to heat. See Plate II. fig. a. This complaint occurs from a greater intenfity of the fame caufe that gives rife to the firft fpecies ; being chiefly found in thofe that ftimulate the mucous expan¬ sion of the ftomach with fpirits, and whofe livers are de¬ ranged in confequence of the fame habit. Its appear¬ ance differs in the following particulars from the prece¬ 233 ding fpecies. In addition to an eruption of fmall fuppu¬ rating tubercles, there is alfo a (hilling rednefs, and an irregular granulated appearance of the (kin of that part of the face which is affeCted. The rednefs commonly appears firft at the end of the nofe, and afterwards fpreads from both fides of the nofe to the cheeks, the whole of which, however, it very feldom covers. In the commencement it is not uniformly vivid ; but is pa¬ ler in the morning, and readily increafed to an intenfe red after dinner, or at any time if a glafs of wine or fpi¬ rits be taken, or the patient be heated by exercife, or by fitting near a fire. After fome continuance in this ftate, the texture of the cuticle becomes gradually thickened, and its furface uneven or granulated, and variegated by reticulations of enlarged cutaneous veins, with fmaller red lines ftretching acrofs the cheeks, and fometimes by the intermixture of fmall fuppurating vari, or pimples, which fucceflively arife on different parts of the face. This fpecies of Ionthus feldom occurs in early life, except where there is an hereditary predifpofition to it ; in general it does not appear before the age of forty ; but it may be produced in any perfon by the conftant immoderate ufe of wine and fpirituous liquors. The greater part of the face, even the forehead and chin, are often affeCted in thele cafes ; but the nofe efpecially be¬ comes tumid, and of a fiery red colour; and, in ad¬ vanced life, it fometimes enlarges to an enormous fize, the noftrils being diftended and patulous, or the alse fif- fured, as it were, and divided into feveral feparate lobes. At that period of life too, the colour of the pimples be¬ comes darker and more livid ; and, if fuppuration take place in any of them, they ulcerate unfavourably, and do not readily a (Tu me a healing difpofition. In young perfons, however, who are hereditarily predifpofed to this complaint, irregular red patches not unfrequently appearin the face, which are often fmooth and free from tubercles, and fometimes throw off (light exfoliations at intervals. Thefe patches may be gradually extended, if great temperance both in food and drink be not obferved, until the whole face afl'ume a preternatural rednefs. As this eruption is chiefly fympathetic of fome de¬ rangement of the chylopoi'etic vifeera, or of a peculiar irritability of the ftomach, little advantage can be ex¬ pected from local applications : and, in fad, the ftimu- lants, which are beneficial under proper regulations, in the other forms of Ionthus, are generally prejudicial in this, and aggravate the complaint. We (hall not enter into any particular directions for the treatment of this complaint. Since this is fo obvious, the firft objeCt to be attained is to induce the patient toabftain from drink¬ ing, feldom an Cafy talk ; and, this being accomplilhed, an abftemious diet and mercurial alteratives will be the principal remedies to be depended on. Dr. Bateman fays the fymptoms may be fometimes palliated by the li¬ quor potaffas, or other antacids, which feem alfo to have fome influence in leffening inflammatory aCtion in the (kin. If the inflammation fubfides, the gentled reftrin- gents (hould be ufed externally to the patches of reticu¬ lated veins ; -fuch as very dilute fpirituous or acetous lotions, with or without a fmall proportion of the ace¬ tate of lead, or Ample ointments combined with alum, acetate of lead, &c. in fmall quantities. Genus V. Phlyfis, [from (p\vu, to boil up, to bubble.] Whitlow. Generic characters — Ulcerative fubcutaneous tumour; flat, tenfive, glabrous, dift'ufed, hot, throbbing ; at length fluctuating with an acrid ichor. There is but one fpecies. Phlyfis paronychia : feated about the nails and ends of the fingers: pain acute and pricking; (hooting up the hand. Three varieties. a. Cutanea : the acrid eftufion feated between the (kin and parts immediately fubjacent. (?. Tendinis : eft'ufion feated between the tendons and the periofteum. y. Perioftii, PATHOLOGY. y. Perioftii, the malignant whitlow, or felon : effufion feated between the periofteum and the bone, which is of¬ ten rendered carious. Similar inflammations are occafionally to be found in the foies of the feet and palms of the hands ; they break through the cuticle with difficulty from its thicknefs, and hence become diffufed, and feparate the cuticle from the flcin beneath. The bite or poifon of the Gordius aquaticus, or hair-worm, is laid to have a pecular ten¬ dency to produce this affedion. Genus VI. Erythema, [Gr. from spsv&oq, rednefs.] In¬ flammatory fluff), improperly called Eryfipelas. Generic characters — Red, glabrous, tumid, fulnefs of the inte¬ guments; difappearing on preflure ; pain burning ; in¬ flammation ulcerative ; terminating in cuticular fcales or veficles, occafionally in gangrene. There are fix fpecies. 1. Erythema adematofum, cedematous inflammation : colour fcarlet ; threading widely and deeply through the cellular membrane, which often imperfedly fuppurates, fioughs, and becomes gangrenous. 2. Erythema eryfipelatofum, eryfipelatous inflamma¬ tion : colour deepi(h-red ; fuperficial ; with a determined edge; migrating in a Terpentine direction; the part which has pafled through the aCtion healing, as the part next attacked becomes aflfeded. 3. Erythema gangraenofum, gangrenous inflammation : colour dulky-red ; fuperficial ; cuticle feparated from the cutis by a bloody ferutn ; the cutis, when denuded, exhibiting dark-brown fpots, difpofed to bliffer and flough ; occurring chieflyr in the extremities. Thefe three fpecies are ufually to be found in debili¬ tated or relaxed conftitutions : the former two often ap¬ pear as fequels of atonic fevers ; the third is common to old age, and early infancy. For the treatment, fee the article Surgery. 4. Erythema veficulare, fiery inflammation : colour pale-red ; furface roughilh, and covered with crowding minute veficles, filled with an acrid, often a reddifti, fluid ; progreflively trailing into the neighbouring found parts. This is intended, as Dr. Good informs us, to deline¬ ate the ignisfiacer of the ancients, which has been feldom underftood, and never hitherto allotted a clear methodic pofition. The common error has been in making it an exanthem, or eruptive fever, an Eryfipelas or a Peffis, or a diftind difeafe approaching to the one or the other. There is no doubt that it has at times been an accompa¬ nying fymptom in Pettis, and has confequently produced a variety in this fever which the reader will find noticed under the head Pettis by the diltinguiffiing term erythe- Kiatica, of which nature was the plague of Athens, fo excellently defcribed by Thucydides and Lucretius. But the ignis facer, in its genuine and fimple ltate, in- ltead of being a typhous eruptive fever, has often very little fever of any kind, never perhaps more than fymp- tomatic fever ; and by Celfus is defcribed as being bed cured by an ephemeral or other fever that may give in- creafed adion to the fyttem. The varieties are, a.. Benignum : the rednefs and veficles advancing without a breach of the cuticle, as the part that has pafled through the adion is healing. /3. Corrofivum : the veficles breaking in the part firft aft’eded, and theerofive fluid producing tracks of fanious ulceration as the rednefs advances. Thefe fubdiviiions of ignis facer are taken from Cel¬ ias, and given, as nearly as may be, in his own words, to prevent all doubt. Fie defcribes it as a genus compri- iing two fpecies, of which the former has two varieties. “ Dus fpecies funt. Alterum eft fubrubicundum, aut mijlv.ni ruborc atque pallore, exafperatumque ' per pvfiulas (OAvxT Kim?) continuas , quarum nulla altera major eft, fed plurimee perexigutx, In his feinper fere pus, et ftepe rubor cum calure eft.” Then follow the two varieties as defcribed above : “ a, Scrpilque id nonnunquum fanefeente eo, quod primum vitiatum eft ; Q, nonnunquam etiam ex- ulcerato, ubi ruptis pujlulis (